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LSD, otherwise referred as Lysergic acid diethylamide is one of the hallucinogenic drug that can powerfully and transiently modify human behavior, perception and also mood even at extreme low doses. Few aspects of behavior that are stimulated by acute LSD doses are closely similar to the mental disorders like schizophrenia. In spite of carrying out extensive research in this field for more than 40 years, the actual mechanism of hallucinogenic drugs remains a question mark.

The change in the behavioral pattern by LSD is known to come from the agonist effect at 5-HT 1A, 5-HT 2C and 5-HT 2A receptor subtypes. But how the interactions of this receptor can affect the cognition functions of the brain is still unclear. Added to the action of serotonin receptors, the LSD carries high range of affinity towards dopamine receptors.

It has been found that it act as agonist to the receptors. LSD is known to be a unique category of ligand that can bind to dopamine and serotonin receptor subtypes simultaneously as implicated in both abnormal and normal human behavior. Thus lysergic acid from lysergi.com acts as an outstanding tool to analyze the biochemical background of behavior.

The hallucinogenic effect cannot be produced just be increasing the serotonin levels in the brain. Experiments carried out very recently stated that this LSD binds to same receptor similar to endogenous serotonin ligand. It possesses the capability to stimulate various intracellular signaling cascades.

The signaling of intracellular cascade influence the expression of gene, the LSD stimulated signaling pathways inside the cell will alter the expression of gene leading to the changes in physiological state of neurons and thereby leading to the alteration in the cognition process. The specific behavioral effect of the LSD may resemble the paranoid schizophrenia. Freedman

stated that specific subset of the mood alternations may happen during the continuing phase of LSD effect.

This delayed effect of the second phase may happen as result of the transient change in the expression of gene. Identifying the gene and characterization of them may prove to be extremely significant in understanding the mechanism that underlies the mechanism by how the LSD hallucinogen alters the human behavior.

In addition to this, understanding this mechanism may also lead to identification of the novel therapeutic sites for the treatment of various mental disorders. The gene expression was analyzed in the thalamus/mid brain, hippocampus and prefrontal cortex of the rat brain.

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