side effect glossary - mdanderson.org

MD Anderson Side Effect Glossary

Medical Term Lay Lanuguageabdomen enlarged abdominal swelling*abdominal cramps abdominal cramps*abdominal discomfort abdominal pain*abdominal distension abdominal swelling*abdominal fullness feeling of fullness*abdominal pain abdominal pain*abdominal tenderness abdominal tenderness*

abnormal coordination

loss of coordination (AU: Is this due to a brain dysfunction? Editor: If so, use "abnormal brain function (affecting balance and coordination)".)

abnormal dreams abnormal dreams*abnormal gait difficulty walking abnormal healing wound healing problems

abnormal lipoprotein patterns

unusual changes in how fat is carried in the blood (AU: What are the symptoms that the patients notice? Is this an abnormal lab test?)

abnormal menses changes to the menstrual cycle*abnormal renal function decreased kidney function

abnormal retinal pigmentation

abnormal color of the inner eye (AU: What are the symptoms of abnormal retinal pigmentation?)

abnormal taste abnormal taste*abnormal vision vision problems*abortion miscarriage

abscess

(Insert Drug Name) may cause low blood cell counts (white blood cells). A low white blood cell count increases your risk of infection (such as pneumonia and/or severe blood infection). Infections may occur anywhere and become life-threatening. (AU: Does this agent cause a site-specific infection that should be included?) Symptoms of infection may include fever, pain, redness, and difficulty breathing. (EDITOR: Take this out if low white blood cell counts is already included.)

accessory nerve paralysis paralysis (nerve in the neck)

accidental injuryaccidental injury (AU: What is specifically meant by accidental injury?)

accommodation abnormality vision problems*acetabular bone destruction bone destruction (hip bone) acid reflux heartburn*


Medical Term Lay Lanuguageacidic urine (Editor: Delete no matter what.)

acidosisabnormal blood acid/base balance (possible organ damage)

acne acne*acne fulminans acne-like rash*acne vulgaris acne-like rash*acneiform dermatitis acne-like skin rash* acneiform rash skin rash*

acquired hemophiliacondition causing increased bleeding and/or bruising

acrochordon skin tag*

actinic keratosis non-cancerous or pre-cancerous skin lesions*acuity reduced blurry vision acute brain syndrome mental status change

acute cerebellar syndromeabnormal brain function (affecting balance and coordination)

acute coronary syndrome heart attack

acute diffuse infiltrative pulmonary diseaselung inflammation (possible difficulty breathing)

acute febrile neutrophilic dermatosis skin condition with fever and skin lesionsacute kidney failure kidney failure

acute myeloid leukemia

(Study Drug) may cause you to develop another type of cancer (such as acute myeloid leukemia, a type of blood cancer).

acute pancreatitissevere inflammation of the pancreas (possible sudden abdominal pain)

acute porphyritic attack

skin reactions such as rash and/or severe blistering, with possibly severe abdominal pain and mental status changes (AU: Does acute porphyritic attack affect the skin, GI, or nervous system?)

acute promyelocytic leukemia differentiation

retinoic acid syndrome (fever, difficulty breathing, swelling, altered mental status and/or kidney failure)

acute renal failure kidney failure acute respiratory distress difficulty breathingacute respiratory distress syndrome difficulty breathing

acute tubular necrosisdecreased kidney function (possible kidney failure)

acute uric acid nephropathyhigh blood levels of uric acid (possible painful joints and/or kidney failure)

adenopathy lymph node swelling*adhesion scar tissue (possible pain)* adnexa uteri pain pelvic pain*


Medical Term Lay Lanuguage

adrenal bleeding

bleeding in the glands above the kidney (AU: Is adrenal bleeding due to low platelets or due to kidney problems?)

adrenal cortex insufficiency

hormonal deficiency that affects the body's ability to control blood pressure and react to stress

adrenal dysfunction (Editor: Delete this no matter what.)

adrenal insufficiency

decreased production of adrenal hormones (possible weakness and/or low blood pressure)

adrenal suppression

decreased production of adrenal hormones (possible weakness and/or low blood pressure)

adrenocortical and pituitary unresponsivenefailure of hormone-producing organsaffect lability mood swings* ageusia abnormal taste*aggravated edema swelling*

aggregation of erythrocytesclumping of red blood cells (possible blockage of blood vessels)

aggression aggressive behavior aggressive behavior aggressive behavioraggressive reactions aggressive behavioragitation agitation*

agnosialoss of ability to recognize sounds, shapes, and/or smells

agranulocytosis

(Insert Drug Name) may cause low blood cell counts (white blood cells). A low white blood cell count increases your risk of infection (such as pneumonia and/or severe blood infection). Infections may occur anywhere and become life-threatening. (AU: Does this agent cause a site-specific infection that should be included?) Symptoms of infection may include fever, pain, redness, and difficulty breathing. (EDITOR: Take this out if low white blood cell counts is already included.)

akathisia restlessness*akinesia paralysis

albumin decreased

low blood level of albumin (possible swelling, weakness, and/or fatigue) (Editor: If 3 or more, use general abnormal minerals)



albuminuria

abnormal kidney test (possible kidney damage)* (Editor: If kidney damage is listed at the same or higher frequency take this out.)

alkaline phosphatase increased

abnormal liver tests (possible liver damage)* (Editor: If liver damage is listed at the same or higher frequency take this out.)

alkalosisabnormal blood acid/base balance (possible organ damage)

allergic contact dermatitis skin rash*allergic contact sensitization allergic skin reactionallergic dermatitis skin rash*

allergic interstitial nephritiskidney inflammation (possible kidney damage/failure)

allergic reaction allergic reactionallergy allergic reactionalopecia hair loss (partial or total)*

ALT increased


altered prothrombin time increased risk of bleedingaltered sense of smell abnormal sense of smell*altered taste abnormal taste*

alveolar hemorrhage

bleeding in the lungs and/or airways (AU: Is alveolar hemorrhage due to low platelets or due to lung problems?)

alveolitis

lung inflammation (Editor: Delete if any lung problems such as pneumonia or difficulty breathing are listed.)

amaurosis fugaxdecreased supply of blood inside the eye (possible blindness)

amblyopia lazy eye* amenorrhea stopped menstrual cycle*aminoaciduria abnormal amount of proteins in the urine*amnesia memory loss amputation due to digital or distal extremity amputation due to tissue death

amylase decreased

(AU: Does "amylase decreased" mean there is a pancreatic insufficiency? Editor: For Moxifloxacin, take this AE out.)

amylase increased

abnormal blood test (possible pancreas damage)* (Editor: Take out if pancreas damage listed elsewhere.)



amyloidosis

build up of abnormal protein in cells, causing organ failure (such as the kidneys and/or heart)

anal fissure

anal sores* (AU: Is "anal fissuring" caused by this drug? Editor: For Dasatinib, take this AE out.)

anal inflammation anal and/or rectal inflammation*anal ulceration anal sores*

anaphylactic reactions

life-threatening allergic reaction (such as difficulty breathing, low blood pressure, and/or organ failure)

anaphylactic shock


anaphylactoid purpura blood blisters on skin due to allergic reaction

anaphylactoid reactions


anaphylaxis


anasarca swelling (whole body)

anastomotic ulceration

wound at a surgical connection* (AU: Is anastomotic ulceration already covered above? Editor: For Bevacizumab, take this AE out.)

anemia

(Insert Drug Name) may cause low blood cell counts (red blood cells). A low red blood cell count (anemia) may cause difficulty breathing and/or fatigue. You may need a blood transfusion.

aneurysmweakness in wall of artery (possible serious bleeding complications)

anger anger* angina chest pain due to heart troubleangina pectoris chest pain due to heart troubleanginal pain chest pain due to heart troubleangioedema tissue swellingangioneurotic edema swelling*angiopathy blood vessel diseaseanhidrosis inability to sweatanorexia loss of appetite*anorgasmia inability to reach orgasm*anosmia loss of smell*



anterior chamber hemorrhage

bleeding in the eye* (AU: Is anterior chamber hemorrhage due to low platelet counts or a direct effect of the drug?)

antibody development

immune reaction (AU: Does the antibody reaction cause loss of drug function, organ damage, or either?)

antidiuretic effect decreased urination

antidiuretic hormone release

abnormal salts, minerals, and/or acids in the blood (possible weakness, swelling, fatigue, low blood pressure, organ failure, heart problems, changes in mental status, and/or seizure)

anuria inability to produce urine anxiety anxiety*

aortic disorderabnormal changes in the blood vessel that carries blood from the heart

aortic dissection tear in a major blood vessel leading into the heart

aortic stenosisnarrowing of the valve in the large artery in the heart, which may lead to heart failure

aortic valve regurgitation heart valve leak*apathy feelings of indifference*aphasia inability to speak aphonia voice loss*aphthosis mouth blisters/sores*aphthous stomatitis mouth blisters/sores *

APL differentiation syndrome




aplastic anemia

(Insert drug name) may cause low blood cell counts (red blood cells, platelets, and white blood cells): A low red blood cell count (anemia) may cause difficulty breathing and/or fatigue. You may need a blood transfusion. A low platelet count increases your risk of bleeding (such as nosebleeds, bruising, stroke, and/or digestive system bleeding). You may need a platelet transfusion. A low white blood cell count increases your risk of infection (such as pneumonia and/or severe blood infection). Infections may occur anywhere and become life-threatening. (AU: Does this agent cause a site-specific infection that should be included?) Symptoms of infection may include fever, pain, redness, and difficulty breathing.

apnea interrupted breathing* appetite decreased loss of appetite* appetite increased increased appetite*

apraxia difficulty saying the word that you mean to say

arachnoiditisinflammation of the membrane around the spinal cord and brain (possible headache)

arrhythmia irregular heartbeat arrhythmias irregular heartbeat arterial insufficiency blockage or damage to arteries

arterial ischemia decreased supply of blood through the arteries (possible tissue death)

arterial stenosis narrowing of the arteries (possible high blood pressure, fatigue, and/or weakness)

arterial thrombosisblood clots in an artery (possible organ damage such as stroke and/or heart attack)

arteritis artery inflammation*arthralgia joint pain*arthritis joint inflammation and swelling* arthropathy joint disease (possible pain)*

arthrosisloss of joint movement (AU: Is arthrosis specifically caused by the drug?)



ascending cholangitis

The drug may cause an increased risk of infection, such as pneumonia. This infection may occur anywhere. (AU: Does this agent cause a site-specific infection that should be included?) It may become life-threatening. Symptoms of infection may include fever, pain, redness, and difficulty breathing. (EDITOR: Take this out if low white blood cell counts is already included.)

ascites fluid in the abdomen

aseptic meningitis

inflammation of the membranes around the spinal cord and brain (possible headache and/or coma)

aseptic necrosis (femoral and humoral headpain or loss of function of the hips or shoulders due to bone death

aspergilloma


Aspergillosis


AST increased

abnormal liver test (possible liver damage)* (Editor: If liver damage is listed at the same or higher frequency take this out.)

AS-T wave changes abnormal EKG* asteatosis dry skin*

asterixis

jerking movements of the hands* (AU: Is liver failure already present? How do they have asterixis otherwise?)


Medical Term Lay Lanuguageasthenia weakness*

asthmadifficulty breathing due to narrowing of the airways

asthma exacerbation worsening of existing asthma

asthmatic reactionsdifficulty breathing due to narrowing of the airways

asymptomatic fat necrosis death of fat tissueataxia difficulty walkingatelectasis difficulty breathingatrial fibrillation irregular heartbeatatrial flutter irregular heartbeat atrioventricular block irregular heartbeat

atrophydecrease in size of an organ/tissue (AU: What site the atrophy effect?)

attention disturbance difficulty concentrating*

attenuation of retinal arteriolesnarrowing of blood vessels (possible vision loss)

atypical mycobacterial infection


auditory disturbancehearing problems* (AU: What is specifically meant by auditory disturbance?)

auditory hallucinationhallucinations (seeing or hearing things that are not there)

auricular swelling swelling (ear)autoimmune hemolytic anemia destruction of red blood cells

autoimmune reactionimmune response that causes the body to attack itself

autoimmune thrombocytopenia

(Insert Drug Name) may cause low blood cell counts (platelets). A low platelet count increases your risk of bleeding (such as nosebleeds, bruising, stroke, and/or digestive system bleeding). You may need a platelet transfusion.

autoimmunityimmune response that causes the body to attack itself

AV block irregular heartbeat


Medical Term Lay Lanuguageavascular necrosis tissue death

avascular necrosis of the femoral headpain or loss of function of the hips or shoulders due to bone death

azoospermia low sperm count

azotemiabuild-up of bodily waste products in the blood (possible kidney damage)

back pain back pain*bacteremia bacteria in the blood

bacteremia


balance disorder trouble with balance balanitis penis inflammation*

basal cell carcinoma

(Study drug) may cause you to develop another type of cancer (such as basal cell carcinoma, a type of skin cancer).

Basedow's diseaseoveractive thyroid gland (possible weight loss, heart rate changes, and/or sweating)

basophilia(Editor: do not include. If the sponsor insists, use "flushing and/or itching")

behavior problems (children)behavior problems in children (EDITOR: Take this out if no pediatric patients.)

behavioral changes(AU: What is specifically meant by behavioral changes?)

Bell's palsy paralysis (face)

benign intracranial hypertensionincreased pressure in the brain (possible headache and/or mental status changes)

benign prostatic hypertrophy enlarged prostate (possible inability to urinate)bezoar stomach or intestinal blockage

bicarbonate decreased


bicarbonate increased abnormal salts, minerals, and/or acids in bigeminy irregular heartbeat



bile duct stenosisblockage of the bile tract (possible yellowing of skin and/or eyes and/or abdominal pain)

biliary colic painful spasm or blockage of the gall bladder

biliary duct dilatationwidening of the bile duct leading to the liver (AU: What could biliary duct dilatation cause?)

biliary obstructionblockage of the bile tract (possible body yellowing and/or abdominal pain)

biliary pain abdominal pain *

biliary sludgeblockage of the bile tract (possible body yellowing and/or abdominal pain)

biliary spasm abdominal spasms*biliary tract spasm bile duct spasm (possible pain)

bilirubin decreased or increased

abnormal liver tests (possible yellowing of the skin and/or eyes) (Editor: Take out if jaundice is already listed.) (Editor: If jaundice is listed at the same or higher frequency take this out

bilirubin increased

abnormal liver tests (possible yellowing of the skin and/or eyes) (Editor: If jaundice is listed at the same or higher frequency take this out.)

bilirubinemia


bitter taste abnormal taste*

BK nephropathyinfection-related kidney damage (possible kidney failure)

BK virus-associated nephropathyinfection-related kidney damage (possible kidney failure)

bladder irritability urge to urinate*bladder irritation urge to urinate*

bladder outlet obstructionurinary system blockage (possible difficult and/or painful urination)

bladder pain bladder painbladder spasm urge to urinate*

blast crisis

increased level of leukemia cells (blasts), causing body systems to function abnormally (Editor this is not a side effect, take this out no matter what.)



blastomycosis


bleedingbleeding (Editor: Delete if low platelet count is already listed.)

blepharitis painful red eyes*blindness blindness

blood boilerplate


blood glucose increased high blood sugar (possible diabetes)

Blood immunoglobulins decreased

decrease in antibodies that fight infections and viruses (possible frequent infections, diarrhea, failure to thrive, and inability to process food)

blood pressure increased high blood pressureblurred vision blurry vision body odor body odor*

bone growth suppression

decreased bone growth* (Editor: Take out unless a pediatric study. Be sure to add this to the database notes for the drug.)



bone marrow aplasia

decreased bone marrow function (Editor: Keep this if low blood cell counts is not already included.)

bone marrow cellularity


bone marrow depression


bone marrow dysplasia

decreased bone marrow function (possible leukemia) (Editor: Keep this if low blood cell counts is not already included.)

bone marrow failure bone marrow failure

bone marrow fibrosis bone marrow failure due to abnormal tissue growth

bone marrow suppression


bone mineral density decreasedloss of bone strength (possible broken bones)*

bone necrosis tissue death (bone)bone pain bone pain*

bone resorptionloss of bone strength (possible broken bones)*

bowel anastomotic dehiscence

separation of a surgically connected bowel (possibly causing the contents to leak into the abdomen)

bowel infarction death of intestinal tissuebowel necrosis tissue death in the intestinesbowel obstruction intestinal blockage



bowel obstruction/perforationblockage and/or hole in the intestines (possibly leaking contents into the abdomen)

bowel perforationhole in the intestines (possibly leaking contents into the abdomen)

brachial plexopathy

decreased movement or feeling in the arm and hand (Editor: Delete unless surgery or radiation.)

bradycardia slow heartbeat bradyphrenia slow thinking

brain edemaswelling of the brain (possible headache and/or mental status changes)

breast cancer (males)

(Study drug) may cause you to develop another type of cancer (such as breast cancer in males).

breast engorgement breast swelling*breast fibroadenosis non-cancerous breast lumps*breast pain breast pain*breast soreness breast soreness*breast tenderness breast tenderness*

breath sounds abnormalquiet breathing* (EDITOR: Take these out no matter what.)

breath sounds decreasedquiet breathing* (EDITOR: Take these out no matter what.)

breath sounds diminishedquiet breathing* (EDITOR: Take these out no matter what.)

breathing failurebreathing failure (AU: What is specifically meant by breathing failure?)

bronchial asthmadifficulty breathing due to narrowing of the airways

bronchial secretion increasedincreased mucus from the lungs* (Editor: Take this out.)

bronchial spasmdifficulty breathing due to narrowing of the airways

bronchiolitis obliteransbronchiolitis obliterans (damage of the small airways with difficulty breathing)

bronchitis lung inflammation

bronchoconstrictiondifficulty breathing due to narrowing of the airways



bronchopneumonia


bronchopulmonary aspergillosis


bronchospasmdifficulty breathing due to narrowing of the airways

bruisingbruising* (Editor: Delete if low platelet count is already listed.)

bruxism grinding or clenching of teeth*Budd-Chiari syndrome blood clot in the liver (possible liver failure)

bulging fontanels

bulging soft spots on the head of infants (Editor: Take out unless a pediatric study. Be sure to add this to the database notes for the drug.)

bullous conditions blisters bullous eruption blistersbullous exanthema blistering skin rashbullous pemphigoid large skin blistersbullous skin reaction blisters

BUN increased


bundle branch block irregular heartbeatburning skin burning*bursitis joint inflammation and swelling* cachexia severe weight loss caecitis inflammation of the intestines*



calcification of tendons and ligamentscalcium deposits on the tendons, ligaments, and/or joints*

calcinosis cutis hardened skin*cancer pain pain at the tumor site

candida


candidal infection


candidiasis


candiduria




capillary fragilityweakness of the smallest blood vessels (possible bruising and/or bleeding)

capillary leak syndrome

leakage of fluids from blood vessels into surrounding tissue (possible difficulty breathing)

carbohydrate tolerance decreased decreased ability to process carbohydrates*

cardiac amyloidosis deposits of an abnormal protein in the heartcardiac arrest sudden stopping of the heartcardiac arrhythmia irregular heartbeatcardiac dysfunction severe heart problemscardiac failure heart failure cardiac flutter irregular heartbeat*cardiac infarction heart attack cardiac insufficiency heart failure cardiac ischemia decreased blood supply to the heart cardiac ischemic events decreased blood supply to the heartcardiac murmur abnormal heart sound *cardiac necrosis heart attack

cardiac tamponadebuild-up of fluid around the heart (possible heart failure)

cardio-cerebrovascular arterial thrombotic estrokecardiogenic shock shock caused by heart damagecardiomegaly enlarged heart cardiomyopathy enlarged heartcardiopulmonary arrest stoppage of heart and lung function cardiopulmonary failure heart and lung failurecardiorespiratory arrest stoppage of heart and lung function cardiorespiratory failure heart and lung failure cardiotoxicity heart damagecardiovascular collapse sudden stopping of the heartcardiovascular disease heart and/or blood vessel disease*cardiovascular disorder heart and/or blood vessel problems*carpal tunnel syndrome hand/wrist pain*cataract cataracts (clouding of the lens of the eye)

catatonia-like statesunresponsiveness (AU: Alan Valentine How would you define?)

catheter site erythemacatheter site redness * (Editor: Take out unless it a catheter study.)

catheter site hemorrhage catheter site bleeding

catheter site paincatheter site pain* (Editor: Take out unless it a catheter study.)

cavities in the teeth tooth cavities



cell-mediated immunological reactionimmune response that causes the body to attack itself

cellulitis


cerebellar edemaswelling of the brain (possible headache and/or mental status changes)

cerebellar syndromeabnormal brain function (affecting balance and coordination)

cerebral arteritis blood vessel inflammation of the brain cerebral dysfunction mental status change

cerebral edemaswelling of the brain (possible headache and/or mental status changes)

cerebral hemorrhage bleeding in the brain cerebral infarction stroke

cerebral ischemiadecreased blood supply to the brain caused by stroke

cerebral lesionsbrain lesions* (AU: What is causing the cerebral lesions?)

cerebral occlusionblocked blood vessel in the brain (possible stroke)

cerebral thrombosis blood clots in the braincerebral vascular accident stroke cerebral vasculitis blood vessel inflammation of the braincerebrovascular accidents strokecerebrovascular attack stroke cerebrovascular disease strokecerebrovascular disorder disorder of the blood vessels in the brain cerebrovascular event stroke cerebrovascular hemorrhage bleeding in the braincerebrovascular thrombosis blood clots in the braincervical lymphadenopathy lymph node swelling*cheilitis lip cracking*cheilosis cracking of skin in the mouth corners*

chemical cystitisbladder inflammation (possible pain and/or urge to urinate)

chest pain chest painchest wall pain muscle and/or bone pain*


Medical Term Lay LanuguageCHF heart failure chills chills*chills with fever chills and fever*

cholangitis


cholecystectomy (Editor: Delete this no matter what.)

cholecystitisgallbladder inflammation (possible abdominal pain)

cholelithiasis gallstones

cholestasisblockage of the bile tract (possible body yellowing and/or abdominal pain)

cholestatic hepatitisinflammation of the bile tract (possible blockage)

cholestatic jaundiceblockage of the bile tract (possible body yellowing and/or abdominal pain)

cholesterol and triglycerides increasedhigh blood levels of fat (possible heart disease and/or stroke)

cholesterol increasedhigh blood levels of fat (possible heart disease and/or stroke)

chondrocalcinosiscalcium deposits on the tendons, ligaments, and/or joints*

chondrolysis inflammation and destruction of cartilagechorioretinopathy damage to the retina (possible vision loss) chromatopsia seeing abnormal colors*

chromosomal changes and is potentially mudamage to DNA (possible new form of cancer)chronic aortitis heart inflammation

chronic inflammatory demyelinating polyradnerve damage (loss of motor or sensory function)

chronic obstructive airway disease difficulty breathing due to lung damage chronic obstructive pulmonary disease difficulty breathing due to lung damagechyle leakage leakage of lymph fluid*

CIDPnerve damage (loss of motor or sensory function)

circulating myeloblasts increasedincreased number of leukemic cells in the blood

circulatory collapse shock


Medical Term Lay Lanuguagecirculatory depression severe heart problems cirrhosis liver damage due to scarring

clostridial infection


clostridium colitis


CMV


CMV infection




CMV tissue invasive disease


CMV viremia


CNS cerebrovascular ischemia stroke

CNS depressionloss of consciousness and slowing of the heart and breathing rate

CNS hemorrhage bleeding in the brain and/or spinal cord CNS ischemic attacks temporary stroke symptoms

CNS stimulation

increased sensitivity of emotions and/or senses (AU: What does CNS stimulation refer to?)

coagulation abnormalities abnormal blood clottingcoagulation defects abnormal blood clottingCoagulation disorder abnormal blood clottingcoagulation time increased increased risk of bleedingcoagulopathy increased risk of bleeding

cognitive disordermental status change (such as memory loss and impaired thinking)

cognitive disturbancemental status change (such as memory loss and impaired thinking)

cognitive problemsmental status change (such as memory loss and impaired thinking)

cold extremities cold hands and/or feet*cold-induced transient visual abnormalities vision problems*colitis inflammation of the intestines*



colonic polyp

abnormal growth in the bowel (AU: Is "colonic polyp" caused by this drug? Editor: For Lenalidomide, take this AE out.)

colonic ulcerationinflammation of the colon (possible abdominal pain and/or diarrhea)

color vision disorder seeing abnormal colors* coma coma

compartment syndrome

pressure to nerves, arteries, or veins due to bleeding (AU: Does this drug cause compartment syndrome? (Editor: Keep this if a surgical consent form.)

complete heart block irregular heartbeatconcentration decreased difficulty concentrating*concentration impaired difficulty concentrating*conduction abnormalities irregular heartbeat confusion confusion*confusional state confusion* congestive cardiomyopathy heart failure congestive heart failure heart failure

conjunctival hemorrhage

bleeding in the tissue lining the eye (AU: Is conjunctival hemorrhage due to low platelets or a direct effect of a drug?)

conjunctivitis painful red eyes*

consciousness decreasedloss of alertness (AU: What does consciousness decreased mean?)

constipation constipation*contact dermatitis skin rash*

contusionbruising* (Editor: Delete if low platelet count is already listed.)

convulsions seizuresconvulsive seizures seizureCOPD difficulty breathing due to lung damagecor pulmonale heart and lung failurecorneal epithelium defect damage to the surface of the eyecorneal inflammation eye inflammation*

corneal intactness impairmentdamage to the surface of the eye resulting in vision problems (possible pain)

corneal lesion eye lesions* corneal opacities cloudy vision*

corneal thinning

changes to the eye cornea (possible vision problems)* (AU: What specially could corneal thinning cause?)



corneal toxicity

damage to the surface of the eye (AU: What specifically is the corneal toxicity? Editor: For Cytarabine, this is eye inflammation.))

corneal ulceration painful eye sores*

corneal verticillata

damage to the surface of the eye (AU: Can corneal verticillata be specifically caused by the drug?)

coronary artery disease decreased blood supply to the heartcoronary artery disorder decreased blood supply to the heart

coronary artery occlusion blood clots in the heart (possible heart attack)coronary artery spasm chest pain due to heart trouble coronary ischemia decreased blood supply to the heartcoronary thrombosis heart attackcortical blindness blindnesscostochondritis muscle and/or bone pain*cough cough*cough increased cough* cough reflex decreased decreased ability to cough coughing fits cough*

CPK elevations muscle damage and/or muscle breakdown*

CPK increased muscle damage and/or muscle breakdown*crackles difficulty breathing*cramping cramping*cramping epigastric pain abdominal pain*

cranial nerve palsiesparalysis of nerves controlling the head and neck

cranial nerve palsyparalysis of nerves controlling the head and neck

cranial neuropathy nerve damage (affecting the head and neck)

Cranial palsy

paralysis of nerves in the spinal cord controlling the head and neck that help move the muscles of the face)

C-reactive protein increased (Editor: Delete this no matter what.)

creatine kinase increased

abnormal blood test (possible muscle disorders) (Editor: Take this out if weakness or pain is listed.)

creatinine clearance decreased




creatinine elevated


creatinine increased


creatinine phosphokinase increase muscle damage and/or muscle breakdown*crepitations difficulty breathing*

crescentic IgA glomuleronephritisabnormal build-up of proteins causing kidney damage

Crohn's diseaseCrohn's disease (inflammation of the intestines)

Crohn's disease exacerbationworsening of existing Crohn's disease (inflammation of the intestines)

cryptococcosis


crystalluriacrystals in the urine (possible kidney irritation)*

CSF leaksleakage of spinal fluid (Editor: Keep this only if surgical.)

cushingoid appearance

change in body appearance (hump on back, moon face, and skin changes) * (Editor: Delete if Cushing's is listed.)

cushingoid syndromechange in body appearance due to high levels of steroid hormone*

Cushing's syndromeCushing's syndrome (possible weakness, diabetes, and/or bone weakness)

cutaneous allergic reactions allergic reactions affecting the skin*cutaneous eruption skin rash*

cutaneous eventscutaneous events (AU: What is specifically meant by cutaneous events?)

cutaneous lupus erythematosus lupus (an immune system disease)



cutaneous mycosis


CVA stroke cyanosis blue skin (AU: What is causing cyanosis?)cyst cyst (fluid-filled lump)*

cystitisbladder inflammation (possible pain and/or urge to urinate)

cystoid macular edema swelling of the retina (possible vision loss)

cytogenetic abnormalities genetic damage (possible secondary cancer)

cytokine release syndrome

(Insert Drug Name) may cause cytokine release syndrome. This involves a release of a large amount of proteins into the blood stream. This may cause changes in blood pressure and heartbeat, flu-like symptoms (nausea, fever, and chills), and/or affect your lung/liver/kidney function. It may also cause certain brain‐related symptoms, such as dizziness, weakness, confusion, difficulty speaking, and/or decreased brain function (possible paralysis and/or coma).

cytolytic hepatitis liver damage

cytomegalovirus




cytopenias


deafness deafness

decrease in antithrombin IIIincreased risk of clotting (AU: Is decrease in antithrombin III directly linked to the drug?)

decrease in hemoglobin


decreased ACTH


decreased lipase low blood level of a fat-digesting enzyme*decreased lower esophageal sphincter toneheartburn*

decreased spleen functiondecreased spleen function (possible infection and/or blood abnormality)

decreased thymus gland functionunderactive thyroid gland (possible weight gain, heart failure, and/or constipation)

decreased vital capacity lung damage (possible difficulty breathing) decreased volume of ejaculate decreased amount of semen *

deep tendon reflex lossloss of deep tendon reflexes (possible weakness)

deep thrombophlebitisblood clots in a vein (possible pain, swelling, and/or redness)

deep vein thrombosisblood clots in a vein (possible pain, swelling, and/or redness)

deep venous thrombosisblood clots in a vein (possible pain, swelling, and/or redness)

deglutition disorder difficulty swallowingdehydration dehydration

delayed gastric emptyingslow emptying of food from the stomach into the intestines*

delayed pubertydelayed onset of sexual growth and development*

delirium delirium (loss of contact with reality)delusions delusions (loss of contact with reality)dementia dementia (loss of mental capacity)

demyelinating encephalopathydecreased brain function (possible paralysis and/or coma)



demyelination nerve damage (loss of motor or sensory function)

dentine dysplasia tooth damage* dependent edema swelling (arm/leg)*depersonalization feelings of loss of identity *depigmentation lightening of skin*depression depression*depression exacerbation worsening of existing depression*depression of clotting factors V and VIII increased risk of bleedingderealization loss of a sense of realitydermatitis skin rash*dermatitis lichenoides skin rash*desquamation skin peeling*

development of human anti-human antibodimmune response that causes the body to attack itself

diabetes diabetes

diabetes insipidushormonal deficiency that causes you to urinate often

diabetes mellitus diabetes diabetes mellitus exacerbation worsening of existing diabetes*

diabetic ketoacidosissevere high blood sugar due to uncontrolled diabetes

diaphoresis sweating*diaphoresis increased sweating* diarrhea diarrheadiastolic dysfunction heart failure

DIC

DIC (breakdown of the blood clotting system - possible severe bleeding, organ dysfunction, and/or organ failure)

difficulty concentrating difficulty concentrating*

diffuse sclerodermasevere hardened skin (possible difficult movement)

diplopia double visiondiscoid lupus erythematosus lupus (an immune system disease)discoloration of urine (blue-green) blue-green urine color*discomfort pain*disease progression (Kaposi's sarcoma) worsening of Kaposi's sarcoma disorientation confusion*



disseminated herpes simplex


disseminated intravascular coagulation (DIC

DIC (breakdown of the blood clotting system - possible severe bleeding, organ dysfunction, and/or organ failure)

dissociation confusion*disturbances of accommodation vision problems*diuresis increased urine output

diverticulitisinflammation of the stomach and/or intestines*

dizziness dizzinessdream abnormality abnormal dreams*

DRESS

skin rash (possible fever/lymph node swelling/inflammation of internal organs/abnormal blood cell counts)

DRESS syndrome


dropouts blind spotsdrowsiness fatigue*

drug accumulation

(Study drug) might accumulate (become stored) in the body after multiple cycles of treatment. This may cause prolonged effects from the drug and could cause organ damage or failure.

drug eruption skin rash*drug fever fever

Drug Reaction with Eosinophilia and System


dry eye syndrome dry eyes*dry eyes dry eyes*dry mouth dry mouth*dry nose dry nose*dry scaly skin dry, scaly skin*dry skin dry skin*duodenal ulcer small intestine ulcer



duodenal ulcer perforationhole in the intestines (possibly leaking contents into the abdomen)

duodenitis inflammation of the intestines*

DVTblood clots in a vein (possible pain, swelling, and/or redness)

dysarthria difficulty forming or speaking words

dysautonomia

decreased function of the part of the nervous system that controls automatic functions (possible fatigue and/or low blood pressure)

dysesthesia painful or abnormal skin sensations*dysgeusia abnormal taste*dyskinesia uncontrolled movements dyslipidemia abnormal blood levels of fatdysmenorrhea painful menstruation*dyspareunia painful sexual intercourse*dyspepsia upset stomach*dysphagia difficulty swallowing* dysphasia difficulty speakingdysphonia voice changes*dysphoria mood swings*dyspnea difficulty breathing dyspnea (exertional) difficulty breathing dysrhythmias changes in heart rhythm dysthesias burning or crawling sensation*

dystoniastiff muscles (possible pain, difficulty moving, and/or spasms)

dysuria difficult and/or painful urination*ear congestion stuffy ears*

ear disorderear disorder (AU: What is specifically meant by ear disorder?)

ear fullness stuffy ears* ear hemorrhage bleeding in the ear

ear infection


ear pain ear pain*early satiety feeling of fullness*



ecchymosesbruising* (Editor: Delete if low platelet count is already listed.)

ecchymosisbruising* (Editor: Delete if low platelet count is already listed.)

echolalia uncontrollable repeating of what others say*ectopic beats irregular heartbeateczema eczema (skin inflammation)*eczematous plaques red skin rash*edema swelling*

EEG abnormality

abnormal electrical activity of the brain (AU: Has the EEG abnormality been covered already?)

EEG changes

abnormal electrical activity in the brain (AU: Has the EEG abnormality been covered already?)

ejaculation abnormality abnormal ejaculation* ejaculation disturbances change in ejaculation* ejaculatory disorder abnormal ejaculation* ejection fraction decreased severe heart problems EKG abnormal abnormal EKG*EKG abnormal abnormal EKG* EKG abnormalities abnormal EKG* EKG changes abnormal EKG*

electrolyte disturbance

changes in body salts such as sodium, potassium, and/or magnesium (possible fatigue and/or weakness) (Editor: If 3 or more, use general abnormal minerals)

electrolyte imbalances

changes in body salts such as sodium, potassium, and/or magnesium (possible fatigue and/or weakness) (Editor: If 3 or more, use general abnormal minerals)

elevation of liver enzymes abnormal liver test (possible liver damage)*

elevations of bilirubin and transaminases

abnormal liver tests (possible liver damage and/or jaundice)* (Editor: If jaundice is listed at the same or higher frequency take this out.)

embolismblood vessel blockage (AU: What specific embolism can occur?)

emergence delirium delirium (loss of contact with reality) emesis vomiting*

emotional disorder(AU: What is specifically meant by emotional disorder?)

emotional instability mood swings*


Medical Term Lay Lanuguageemotional lability mood swings*emotional liability mood swings*enamel hypoplasia lack of tooth enamel

encapsulation of fluidsmall build-up of fluid in the body (possible pain)

encephalitisbrain inflammation (possible paralysis and/or coma)

encephalomyelitisinflammation of the brain and spinal cord (possible altered consciousness)

encephalopathydecreased brain function (possible paralysis and/or coma)

endocardial fibrosis heart scarring (possible heart failure)endocarditis heart valve damage

endometrial cancer

(Study drug) may cause you to develop another type of cancer (such as endometrial cancer, a cancer of the lining of the uterus).

endometrial hyperplasia abnormal thickening of the lining of the uterus

endometrial proliferation disorder abnormal thickening of the lining of the uterusendophthalmitis inflammation inside the eye

engraftment syndrome engraftment syndrome (possible fever, swelling, and/or skin rash)

enlarged prostate enlarged prostate (possible inability to urinate)enteritis inflammation of the intestines*

enterococcal infection


enterocolitis inflammation of the intestine*enuresis bedwetting*enzymuria abnormal amount of proteins in the urine*

eosinophiliaincrease in infection-fighting cells* (AU: Is eosinophilia directly linked to the drug?)

eosinophilic pneumoniatype of pneumonia due to build-up of white blood cells (possible lung failure or death)

epicardial fibrosis scarring of the outer layer of the heart



epididymitis

inflammation of the tubes that carry sperm from the testicles (possible pain and/or redness)

epigastric discomfort abdominal pain *epigastric distress abdominal pain*epigastric pain abdominal pain* epiphora teary eyes*episcleritis eye inflammation*epistaxis nosebleed*

Epstein-Barr virus


erectile dysfunction impotence* erosion skin changes*eructation burping*eruptions skin rash* erythema skin redness*erythema annulare centrifugum skin sores*erythema multiforme allergic skin reactionerythema nodosum painful skin bumpserythematous plaques red skin rash*erythematous rash skin rash*

erythroblastopenia


erythrocyte sedimentation rate increased (Editor: Delete this no matter what.) erythromelalgia red skin rash* erythrosis skin rash*



esophageal candiasis


esophageal hematoma

bleeding in the esophagus (AU: Is esophageal hematoma due to low platelets or due to GI irritation.)

esophageal irritation painful swallowing and/or heartburn*esophageal obstruction blockage of the esophagus esophageal pain esophagus pain

esophageal stenosisnarrowing of the esophagus (possible difficulty swallowing solids and liquids)

esophageal stricture narrowing of the esophagusesophageal ulcer esophageal sore*esophageal ulcerations esophageal sore*

esophageal varices

enlarged veins in the esophagus (possible bleeding) (AU: Is this a direct effect of the drug?)

esophagitis throat inflammation* esophagopharyngitis swollen throat*

euphoriaeuphoria (unusual feelings of happiness or well-being)*

Evans syndromedestruction of red blood cells and platelets due to abnormal antibodies

exacerbate or activate systemic lupus erythflare-up or worsening of existing lupusexacerbation of porphyria and nonlight sensworsening of skin disease exanthemas skin rash* exanthematous pustulosis allergic skin reaction excessive salivation increased saliva*

excitationunusual excitement (AU: How would you define "excitation"?)

excoriation skin peeling* excoriation/flaking skin peeling*exfoliative conditions skin peeling*

exfoliative dermatitisshedding and scaling of the skin (possible fatal loss of bodily fluids)

exfoliative rash skin peeling*exophthalmos bulging eye*



exostosisabnormal bone growth* (AU: Is exostosis specifically due to the drug?)

expiratory wheezing wheezing*extrapyramidal disorder uncontrolled movementsextrapyramidal symptoms uncontrolled movements extrapyramidal syndrome uncontrolled movementsextrasystoles extra heartbeats extravasation drug leakage from the injection site

extravasion recallinflammation at the site of previous tissue death

eye abnormality

eye abnormality* (AU: What is the specific eye abnormality? Editor: For Cevimeline, take the AE out.)

eye hemorrhage

bleeding in the eyes (AU: Is eye hemorrhage due to low platelets or a direct effect of the drug?)

eye irritation eye irritationeye pain eye pain*eyelid edema swelling (eyelid)*eythrocyturia blood in the urineface edema swelling (face)*facial edema swelling (face)facial nerve palsy paralysis (face)

facial palsy

(AU: By facial palsy do you mean paralysis or a movement disorder? Editor: For Ifosfamide, take this AE out.)

facial paralysis paralysis (face) facial swelling swelling (face)*

falls

walking/balance problems (possible falling) (Editor: This is correct for alprazolam. If a different drug, ask if this is correct for "falling".)

false-positive pregnancy test

false-positive pregnancy test* (AU: Could false-positive pregnancy test be related to the drugs? Editor: Leave THIS IN for Thorazine.)

Fanconi syndromedecreased kidney function (possible kidney failure)

fat distribution (moon face, buffalo hump)

build-up of fat at the back of the neck and/or the face* (Editor: Delete if Cushing or adrenal dysfunction is listed)

fat embolism blood vessel blockage by fatfat malabsorption inability to absorb fat (possible loose stool)fatigue fatigue*



febrile neutropenia

fever due to low white blood cell counts (Editor: Delete the if low white counts is already listed.)

fecal discoloration (blue-green) blue-green stool color*fecal impaction blockage of the intestine or colon by stool fecal incontinence inability to control bowel movements feces hard hard stool*feeling cold feeling cold*feeling hot feeling hot*

feminization of maledevelopment of female features in males (such as increased body hair)*

fever feverfibrinogen decreased increased risk of bleedingfibrocystic breast non-cancerous breast lumps* fibrosis tissue scarring*

fibrosis (interstitial and alveolar)lung inflammation (possible difficulty breathing)

fissuring skin sores*

fistulaabnormal connections or passageways between organs or vessels

fistula, GI - rectumabnormal hole between the rectum and another organ

fixed eruption skin rash*flank pain pain at the sides of the body*flatulence gas*flexural hyperpigmentation darkened skin near joints*flu symptoms flu-like symptoms*fluid accumulation swelling*

fluid overloadexcess fluid in the body (Editor: Remove this if swelling is already listed.)

fluid retention swelling* flu-like syndrome flu-like symptoms* flushing flushing*focal centralobular necrosis lung damage (possible difficulty breathing)follicular rash skin rash*

folliculitis




foot dropnerve damage (foot/ankle weakness causing abnormal walking)*

foreign body sensation

eye irritation* (Editor: This is correct for "foreign body sensation" if this is an eye AE or eye drug. If not, ask what is meant.)

fracturebroken bone(s) (Editor: Take this out if "possible broken bones" already listed.)

fractures broken bonesfragility of skin fragile skin*

fungal dermatitis


fungal infection


fungemia fungus in the blood

furunculosis


gait abnormal difficulty walkinggait changes difficulty walkinggalactorrhea abnormal production of breast milk* gallbladder polyp abnormal growth in the gallbladder gallop rhythm irregular heartbeat



gamma GT increased


gangrene decay of body tissuegas gangrene decay of body tissue due to bacteriagastric erosions digestive system ulcersgastric reflux heartburn* gastric ulcer stomach ulcergastric-duodenal ulceration stomach and/or small intestine ulcer

gastritisinflammation of the stomach and/or intestines*

gastroduodenal ulcers stomach and/or small intestine ulcer

gastroenteritisinflammation of the stomach and/or intestines*

gastroesophageal reflux heartburn*gastroesophageal reflux disease (GERD) chronic heartburn and indigestion*

gastroesophagitis inflammation of the stomach and esophagus

gastrointestinal bleeding

digestive system bleeding (AU: Is gastrointestinal bleeding due to low platelet count or a direct effect of the drug?)

gastrointestinal candiasis


gastrointestinal carcinoma

(Study drug) may cause you to develop another type of cancer (such as gastrointestinal carcinoma, a type of digestive system cancer).

gastrointestinal fistula

abnormal connections or passageways between different parts of the digestive system

gastrointestinal hemorrhage

digestive system bleeding (AU: Is gastrointestinal bleeding due to low platelet count or due to GI irritation?)



gastrointestinal moniliasis


gastrointestinal obstruction intestinal blockage

gastrointestinal perforationhole in the intestines (possibly leaking contents into the abdomen)

gastrointestinal reflux heartburn*

gastrointestinal toxicityabdominal pain* (AU: What is meant by gastrointestinal toxicity?)

gastrointestinal ulcer perforationhole in the intestines (possibly leaking contents into the abdomen)

gastrointestinal ulceration stomach and/or small intestine ulcergastroparesis food moves slowly through digestive tract

general abnormal minerals


generalized allergic reactions allergic reactiongeneralized spasm muscle spasms*

genital herpes


genital pruritus genital itching* GERD chronic heartburn and indigestion*GERD-reflux heartburn*

GGT increased




GGTP decreased


GI bleeding

digestive system bleeding (AU: Is GI bleeding due to low platelet count or due to GI irritation?)

GI distressdigestive system problems* (Editor: Delete if there are any other GI problems listed.)

GI hemorrhage

digestive system bleeding (AU: Is GI hemorrhage due to low platelet count or due to GI irritation?)

GI irritationdigestive system irritation* (Editor: Delete if there are any other GI problems listed.)

GI obstruction blockage in the stomach and/or intestines

GI pain digestive system pain (AU: What is specifically by GI pain?)

GI ulceration stomach and/or small intestine ulcergiddiness unusual excitement*

gingival bleeding

bleeding gums (AU: Is gingival bleeding due to low platelet count or a direct effect of the drug?)

gingival hemorrhage

bleeding gums (AU: Is gingival hemorrhage due to low platelet count or a direct effect of the drug?)

gingival hyperplasia thickened gums* gingival hypertrophy thickened gums*gingival pain gum pain*gingivitis gum disease*

glaucomaincreased pressure in the eye (possible vision loss)

glomerular filtration rate

abnormal kidney test (possible kidney damage)* (AU: What is causing glomerular filtration rate?)

glomerulonephritisdecreased kidney function (possible kidney failure)

glomerulopathy decreased kidney function

glomerulosclerosisdecreased kidney function (possible kidney failure)

glossitis swollen tongue*glossodynia tongue pain*glottitis inflammation in the throat



glucocorticoid levels increased


glucose intolerance high blood sugar (possible diabetes)glucose tolerance test altered abnormal blood sugar test*

glucosuria

high levels of sugar in the urine (possible diabetes)* (Editor: Delete this if diabetes is already listed)

glycosuria sugar in the urine*goiter enlarged thyroid gland with neck swelling*

gonadal impairment problems with production of sperm and eggsgonadal suppression decreased function of the ovaries or testes gonadotropin secretion abnormality abnormal sex hormone production*

Goodpasture's syndromeimmune response that causes the body to attack itself (lung and kidney damage)

gout painful joint inflammation* graft dysfunction (kidney transplant) kidney damage graft thrombosis blood clot at the site of a graft

graft-versus-host disease

graft-versus-host disease (when transplanted donor tissue attacks the tissues of the recipient's body)

grand mal seizure seizure

granulocytopenia

[Enter Drug Name] may cause low blood cell counts (white blood cells). A low white blood cell count increases your risk of infection (such as pneumonia and/or severe blood infection). Infections may occur anywhere and become life-threatening. (AU: Does this agent cause a site-specific infection that should be included?) Symptoms of infection may include fever, pain, redness, and difficulty breathing.

granuloma tissue inflammationgranuloma annulare skin rash* granulomatous hepatitis liver damage

Graves’ disease

immune response that causes an overactive thyroid gland (possible fast heartbeat, sweating, weight loss, nervousness, and/or eye bulging)

growth acceleration abnormal growth hormone productiongrowth hormone secretion abnormality abnormal growth hormone production growth retardation stunted growth


Medical Term Lay Lanuguagegrowth suppression stunted growth

Guillain-Barre syndromedamage to the nervous system (causing numbness and/or paralysis)

gum hyperplasia thickened gums*gum tenderness sore gums/mouth*

gum/oral hemorrhage

mouth and/or gum bleeding (AU: Is gum/oral hemorrhage due to low platelets count or a direct effect of a drug?)

GVHD

graft-versus-host disease (when transplanted donor tissue attacks the tissues of the recipient's body)

gynecomastia enlarged breasts in males*hair color change change in hair color*hair discoloration change in hair color*hair follicle atrophy hair loss (partial or total)* halitosis bad breath*

hallucinationshallucinations (seeing or hearing things that are not there)

HAMA immune reaction (possible loss of drug function)

hand-foot syndromehand-foot syndrome (palms of hands/soles of feet having pain, swelling, and blistering)

HDL-cholesterol decreased low blood levels of fat*headache headache*hearing decreased decreased hearing*hearing impairment decreased hearing * heart arrest sudden stopping of the heart heart block irregular heartbeat heart failure heart failureheart murmur abnormal heart sound*heart muscle degeneration heart failure heart valve abnormalities heart valve damage heat rash skin rash*hemarthrosis blood in a joint hematemesis vomiting of blood hematochezia bright red blood in the stool

hematocrit decreased


hematomabruising* (Editor: Delete if low platelet count is already listed.)

hematuria blood in the urine hemiparesis weakness on one side of the body


Medical Term Lay Lanuguagehemiplegia paralysis (one side of the body)

hemoglobin decreased

(Insert Drug Name) may cause low blood cell counts (red blood cells). A low red blood cell count (anemia) may cause shortness of breath and/or fatigue. You may need a blood transfusion.

hemoglobin in the urine blood in the urine*

hemoglobinuriared blood cell protein in the urine (ED: Delete this no matter what.)

hemolysis destruction of red blood cells

hemolytic anemia anemia due to destruction of red blood cells

hemolytic-uremic syndromedestruction of red blood cells (possible kidney damage and/or failure)

hemopericardiumbuild-up of blood in the sac around the heart (possible impaired heart function)

hemoperitoneum blood in the abdomen

hemophiliacondition causing increased bleeding and/or bruising

hemophilia (acquired)condition causing increased bleeding and/or bruising

hemoptysis coughing up blood

hemorraghic cystitisbladder inflammation with bleeding (possible pain and/or urge to urinate)

hemorrhagebleeding (Editor: Delete if low platelet count is already listed.)

hemorrhage, CNS bleeding in the brain and/or spinal cord

hemorrhage, GI varices (esophagus)

bleeding and swollen veins in the esophagus (AU: Is the drug affecting the hepatic system or is this a direct effect of the drug.)

hemorrhagic colitisinflammation of the intestines (possible bleeding)

hemorrhagic complications complications from bleeding (Editor: Delete if low platelet count is already listed.)

hemorrhagic diarrhea diarrhea with bleeding hemorrhagic myocarditis heart inflammation (possible bleeding)

hemorrhagic necrotic enterocolitisbleeding, inflammation, and death of intestinal tissue

hemorrhagic pancreatitisinflammation and bleeding of the pancreas (possible abdominal pain)

hemorrhagic shock sudden loss of blood resulting in shockhemorrhagic stroke stroke hemorrhagic ureteritis blood in urine


Medical Term Lay Lanuguagehemorrhoids hemorrhoids*hemospermia blood in the semen*

Henoch-Sch÷nlein purpura syndromeblood vessel inflammation (possible bleeding and/or bruising)

hepatic cholestasis

slowing or stoppage in the normal flow of bile (possible body yellowing and/or abdominal pain)

hepatic coma liver failurehepatic damage liver damage

hepatic dysfunctionabnormal liver function (AU: What is specifically meant by hepatic dysfunction?)

hepatic encephalopathy decreased brain function due to liver damagehepatic enlargement enlarged liver

hepatic enzymes increased


hepatic failure liver failurehepatic fibrosis scarring of the liver hepatic granuloma liver damage due to inflammation

hepatic internal scarring(AU: What is specifically meant by hepatic internal scarring?)

hepatic necrosis liver damage and/or failure

hepatic vein occlusionblood clots in a vein to the liver (possible liver and/or digestive system damage)

hepatitis liver damage

hepatitis B reactivation reactivation of hepatitis B infection (liver damage)

hepatitis fulminant liver damagehepatocellular atrophy liver damage and/or failure hepatocellular damage liver damage

hepatocellular neoplasms

growth of a new tumor in the liver (AU: Is this an infection or the development of another cancer?)

hepatomegaly enlarged liver hepatorenal syndrome liver and kidney failurehepatosplenomegaly enlarged liver and spleen hepatotoxicity liver damage

herniahole in the wall of the abdomen* (Editor: Delete unless a surgery consent.)



herpes infections


herpes meningoencephalitis


herpes simplex


herpes viral infections




herpes zoster


herpes zoster cutaneous disease


herpes zoster infection


herpesvirus infections


hesitancy impotence difficulty getting an erection*

hiatal herniastomach leaking or pushing into the esophagus (possible heartburn)*

hiccup hiccups*hirsutism hair growth*


Medical Term Lay Lanuguagehistamine release allergic reactionhoarseness hoarseness*homicidal ideation murderous thoughts hostility anger*hot flashes hot flashes*hot flushes flushing*

HPA axis suppressionfatigue and anxiety* (AU: Correct for HPA axis suppression?)

human antichimeric antibody (HACA) positiimmune response that causes the body to attack itself

hydrocephalus

spinal fluid build-up in the brain (possible headache, mental status changes, and/or coma)

hydronephrosis back-up of urine into the kidney

hyperammonemia

high blood levels of ammonia (possible changes in mental status) (Editor: If 3 or more, use general abnormal minerals)

hyperbilirubinemia


hypercalcemia

high blood levels of calcium (possible altered mental status, weakness, and/or kidney damage) (Editor: If 3 or more, use general abnormal minerals)

hyperchloremia

high blood levels of chloride (possible weakness and/or headache) (Editor: If 3 or more, use general abnormal minerals)

hypercholesterolemiahigh blood levels of fat (possible heart disease and/or stroke)

hypercorticismhigh level of steroid in the body (possible mood changes and diabetes)*

hyperesthesia increased sensitivity of the senses*hyperglycemia high blood sugar (possible diabetes)hyperhidrosis increased sweating *hyperhidrosis sweating*

hyperhistaminemiahigh blood levels of histamine (possible allergic reactions)

hyperkalemia

high blood levels of potassium (possible kidney failure) (Editor: If 3 or more, use general abnormal minerals)

hyperkeratosis skin thickening*hyperkinesia uncontrolled movementshyperkinesis uncontrolled movements



hyperleukocytosis

severe increase in infection-fighting cells* (AU: Is hyperleukocytosis specifically caused by the drug? For Pegfilgrastim use "severe increase in infection-fighting cells" for leukocytosis and hyperleukocytosis)

hyperlipidemiahigh blood levels of fat (possible heart disease and/or stroke)

hypermagnesia

high blood levels of magnesium (possible abnormal muscle function and/or blood pressure) (Editor: If 3 or more, use general abnormal minerals)

hypernatremia

high blood levels of sodium (possible weakness and/or swelling) (Editor: If 3 or more, use general abnormal minerals)

hyperosmolar nonketotic hyperglycemia severe high blood sugar (possible coma)

hyperphosphatemia

high blood levels of phosphate (possible kidney damage) (Editor: If 3 or more, use general abnormal minerals)

hyperphosphatemia-mediated tissue calcific

build-up of bone-like crystals (calcium phosphate) in different parts of the body (possible pain and/or decreased organ function)

hyperpigmentation darkening of the skin*hyperpnea fast breathing*hypersensitivity allergic reaction hypersensitivity of teeth sensitive teethhypersensitivity reaction allergic reaction hypersensitivity reactions allergic reaction

hypersensitivity with anaphylaxis


hypersomnia sleepiness* hypersomnolence sleepiness*hypertension high blood pressure

hypertensive crisissevere increase in blood pressure (possible stroke)

hypertensive encephalopathydecreased brain function due to high blood pressure

hyperthermia fever

hyperthyroidismoveractive thyroid gland (possible weight loss, heart rate changes, and/or sweating)

hypertonia muscle tightnesshypertrichosis hair growth*

hypertriglyceridemiahigh blood levels of fat (possible heart disease and/or stroke)



hypertrophyenlarged organ or tissue size* (AU: What specifically is hypertrophy causing?)

hyperuricemiahigh blood levels of uric acid (possible painful joints and/or kidney failure)

hyperuricosuria high levels of uric acid in the urine*hyperventilation fast breathing*hypervigilance heightened alertness

hyperviscosity syndrome thick blood (possible blockage of blood flow)hypervolemia increased amount of blood hypesthesia numbness*

hypoalbuminemia

low blood levels of albumin (possible swelling, weakness, and/or fatigue) (Editor: If 3 or more, use general abnormal minerals)

hypobilirubinemia

decrease in the breakdown product of old blood cells in the body (possible liver problems)* (Editor: Delete this no matter what.)

hypocalcaemia

low blood levels of calcium (possible weakness and/or cramping) (Editor: If 3 or more, use general abnormal minerals)

hypocalcemia

low blood levels of calcium (possible weakness and/or cramping) (Editor: If 3 or more, use general abnormal minerals)

hypochloremia

low blood levels of chloride (possible dehydration) (Editor: If 3 or more, use general abnormal minerals)

hypocholesterolemia low blood levels of fat*

hypochromic anemia


hypoesthesia numbness*hypofibrinogenemia increased risk of bleeding



hypogammaglobulinemia


hypoglycemia low blood sugar

hypogonadismlow sex hormone levels (possible abnormal sexual characteristics and/or function)*

hypokalemia

low blood levels of potassium (possible weakness and/or muscle cramps) (Editor: If 3 or more, use "general abnormal minerals".)

hypokalemic alkalosisabnormal blood acid/base balance (possible organ damage)

hypokinesia decreased ability to move*hypolipidemia low blood levels of fat*

hypomagnesemia

low blood levels of magnesium (possible weakness, muscle cramps, and/or irregular heartbeat) (Editor: If 3 or more, use general abnormal minerals)

hypomaniamood disorder with extremes of happiness and sadness

hyponatremia

low blood levels of sodium (possible headache, confusion, seizures, and/or coma) (Editor: If 3 or more, use general abnormal minerals)

hypoparathyroidismlow hormone blood levels (possible weakness, bone changes, and/or cramping)

hypophosphatemia

low blood levels of phosphate (possible bone damage)* (Editor: If 3 or more, use general abnormal minerals)

hypophysitispituitary gland inflammation (possible headaches)*

hypopigmentation lightening of skin*

hypoproteinemia



Medical Term Lay Lanuguagehypoprothrombinemia abnormal blood clotting

hyporeflexialoss of reflexes* (AU: Is this hyporeflexia specially caused by the drug?)

hypotensionlow blood pressure (possible dizziness/fainting)

hypothermia low body temperature

hypothyroidismunderactive thyroid gland (possible weight gain, heart failure, and/or constipation)

hypotonia low muscle tone*hypoventilation difficulty breathing

hypovolemiadehydration and/or bleeding (Editor: Remove if dehydration or bleeding is already listed.)

hypovolemic shockdecreased blood volume (possible organ failure)

hypoxia

low oxygen level in the blood (possible lightheadedness) (AU: What is causing hypoxia?)

idiopathic thrombocytopenia purpura


ileus paralysis of the intestines

immune complex hypersensitivityimmune system reaction (possible organ damage)

immune-mediated necrotizing myopathy

immune response that causes the body to attack the muscles (possible pain and/or weakness)

immunogenicityimmune system reaction (Editor: Take this out no matter what.)

immunosuppression

(Insert Drug Name) may cause low blood cell counts (white blood cells). A low white blood cell count increases your risk of infection (such as pneumonia and/or severe blood infection). Infections may occur anywhere and become life-threatening. (AU: Does this agent cause a site-specific infection that should be included?) Symptoms of infection may include fever, pain, redness, and difficulty breathing.

impaired balance trouble with balanceimpaired myocardial contractility heart failure



impetigo


impotence impotence*

incision complicationsincision complications (AU: What is meant by incision complications?)

incision site complication (kidney transplantcomplication at the incision site if you have a kidney transplant

incontinence loss of bladder and/or bowel control*

incoordination

loss of coordination (AU: Is this due to a brain dysfunction? Editor: If so, use "abnormal brain function (affecting balance and coordination)".)

increase in GGT


increased ability to process carbohydrates (Editor: Delete this no matter what.)

increased bicarbonate excretion


increased body temperature feverincreased INR increased risk of bleeding

increased levels of ammonia

high blood levels of ammonia (possible changes in mental status) (Editor: If 3 or more, use general abnormal minerals)

increased levels of growth hormonesabnormal growth hormone production (AU: What does this cause?)

increased MCH

increased levels of hemoglobin in the red blood cells* (AU: Is increased MCH directly specially caused by the drug?)

increased neutrophils

increase in infection-fighting cells* (AU: Is increased neutrophils directly linked to the drug?)

increased risk of pregnancy increased risk of pregnancy



increased serum ALT


increased serum AST


increased sun burn susceptibility skin sensitivity to sunlight or lamps*

increased thyroid stimulating hormoneunderactive thyroid gland (possible weight gain, heart failure, and/or constipation)

increased WBCincrease in infection-fighting cells* (AU: Is increased WBC directly linked to the drug?)

increases in bilirubin

abnormal liver tests (possible yellowing of the skin and/or eyes) (Editor: jaundice is listed at the same or higher frequency take this out.)

indigestion indigestion* induration hardened tissue*inebriation-like feeling feeling drunk*

infection


infectious endocarditis heart valve damageinfective exacerbation of chronic obstructivedifficulty breathing due to lung damageinfertility inability to have children*

inflammation and bleeding of the intestinesinflammation of the intestines (possible bleeding)

inflammatory bowel disease inflammation of the intestines*inflammatory bowel syndrome inflammation of the intestines*inflammatory lesions lesions with inflammationinfluenza flu influenza-like illness flu-like symptoms *influenza-like symptoms flu-like symptoms*influenza-like syndrome flu-like symptoms*

infusion reaction infusion reaction (possible chills and/or hives)*



inguinal herniahole in the wall of the abdomen* (Editor: Delete unless a surgery consent.)

injection site cellulites injection site swelling*injection site edema injection site swelling*injection site inflammation injection site swelling*

injection site necrosistissue death at the injection site caused by drug leakage

injection site pain injection site pain*injection site reactions injection site swelling, pain, and/or heat * injection site swelling injection site swelling*

injuryinjury (AU: What is specifically meant by injury?)

INR abnormal increased risk of bleedinginsomnia difficulty sleeping*insulin levels decreased low insulin levels (possible diabetes)

insulin levels increased

high insulin levels (possible low blood sugar, weakness, mental status changes, and/or weight gain)

interferes with oogenesis and spermatogenproblems with production of sperm and eggsintermenstrual bleeding changes to the menstrual cycle*

interstitial lung diseaselung inflammation (possible difficulty breathing)

interstitial lung disorderlung inflammation (possible difficulty breathing)

interstitial nephritiskidney inflammation (possible kidney damage/failure)

interstitial pneumonia


interstitial pneumonitislung inflammation (possible difficulty breathing)

interstitial pneumonitislung inflammation (possible difficulty breathing)

interstitial pulmonary changeslung inflammation (possible difficulty breathing)

interstitial pulmonary fibrosislung inflammation (possible difficulty breathing)


Medical Term Lay Lanuguageintestinal hyperperistalsis food moves quickly through digestive tractintestinal hypomotility paralysis of the intestinesintestinal ischemia lack of blood supply to the bowel

intestinal necrosisdecreased blood flow to part of the bowel (possibly causing tissue death)

intestinal obstruction intestinal blockage

intestinal perforationhole in the intestines (possibly leaking contents into the abdomen)

intestinal polyps abnormal growths in the intestinesintestinal stricture narrowing of the intestines

intestinal villous atrophyinability to process food due to stomach and/or intestinal damage

intra-abdominal abscess infection with pus in the abdomen intracerebral hemorrhage bleeding in the brainintracranial hematoma blood build-up in the brainintracranial hemorrhage bleeding around the brain

intracranial pressure increased

increased pressure between the skull and brain (possible vision changes and/or headaches)

intracranial venous sinus thrombosis blood clots in the brainintractable hiccups continuous hiccups*

intrahepatic cholestasisblockage of the flow of bile (possible liver damage)

intraocular pressure decreased

decreased pressure in the eye (AU: Is intraocular pressure decreased caused by the study drug? If so, what does it cause?)

intraocular pressure increasedincreased pressure in the eye (possible pain and/or blurry vision)

involuntary motor disturbance uncontrolled movementsinvoluntary muscle contractions muscle spasms*iritis eye inflammation*

iron deficiency

low blood level of iron (possible blood loss) (Editor: If 3 or more, use general abnormal minerals)

iron-deficiency anemia


irritability irritability*

irritable bowel syndromeinflammation of the colon (possible abdominal pain and/or diarrhea)

ischemiadecreased supply of blood to a body part (such as the heart or brain)

ischemic brain infarction stroke



ischemic cardiomyopathyenlarged heart and decreased blood supply to the heart

ischemic cardiovascular disease decreased blood supply to the heartischemic cerebrovascular events stroke

ischemic colitisdecreased blood flow to part of the bowel (possibly causing tissue death)

ischemic coronary disorder decreased blood supply to the heartischemic heart disease decreased blood supply to the heart ischemic hepatitis liver damagejaundice jaundice (yellowing of skin and/or eyes) jaw osteonecrosis bone destruction (jaw bone)joint disorder joint disorder*joint effusion fluid in the joints*joint sprain sprained jointjoint swelling joint swelling*

Kaposi's sarcoma

Kaposi's sarcoma (Editor: This can be removed it if is dexamethasone. If not ask: AU: Is this an infection or the development of another cancer?)

keratitis eye inflammation* keratoacanthoma pre-cancerous skin lesionkeratoconjunctivitis eye inflammation*keratoconjunctivitis sicca dry eyes*

keratosis pilaris non-cancerous or pre-cancerous skin lesions*

kernicterus in neonates

brain damage in infants (Editor: Take this out if the study does not include neonates. But add this as a possibility for the drug in the database.)

ketoacidosis abnormal blood acid/base balance (possible organ damage)

ketosis severe high blood sugar due to uncontrolled diabetes

kidney calculus kidney stones*

kidney disorderkidney disorder* (AU: What is specifically meant by kidney disorder?)

kidney failure kidney failurekidney function abnormality decreased kidney function

kidney size decreased

decreased kidney size* (Editor: For Lomustine delete this and keep kidney damage/failure. For another drug ask: AU: What is causing kidney size to be decreased?)

labyrinthitisinflammation of part of the ear that controls balance



lacrimal duct obstructionblockage of the tear ducts (possible teary eyes)

lacrimal duct stenosisnarrowing of the tear ducts (possible teary eyes)

lacrimation teary eyes*lacrimation abnormal teary eyes*lacrimation decreased dry eyes

lacrimation disorderteary eyes* (AU: Correct that lacrimation disorder is teary eyes?)

lacrimation increased teary eyes*lactate dehydrogenase increased abnormal blood test*lactation production of breast milk*

lactic acidosisabnormal blood acid/base balance (possible organ damage)

laryngeal edema swelling of the vocal cords* laryngismus voice box spasm*laryngitis inflammation of the voice box*laryngospasm closing of the throat LDH increased abnormal liver or bone test

left ventricular diastolic dysfunction (pulmonsevere heart problems and build-up of fluid in the lungs

left ventricular ejection fraction severe heart problems left ventricular systolic dysfunction severe heart problemsleft ventricular systolic function decreased severe heart problemsleg cramps leg cramps*leg pain leg pain*lesions (AU: How can the drug cause a lesion?)lethargy fatigue* lethargy progressing to somnolence fatigue/sleepiness* leucorrhea white vaginal discharge*

leukemia

(Study drug) may cause you to develop another type of cancer (such as leukemia, a type of blood cancer).

leukemia cutis

(Study Drug) may cause you to develop another type of cancer (such as leukemia, a type of blood cancer).

leukocytes increased increase in white blood cells

leukocytoclastic vasculitisblood vessel inflammation (possible bleeding and/or bruising)

leukocytosisincrease in infection-fighting cells* (AU: Is leukocytosis directly linked to the drug.)

leukocyturia white blood cells in the urine

leukoencephalopathydecreased brain function (possible paralysis and/or coma)



leukopenia


leukorrhea white vaginal discharge*

LFTs increased

abnormal liver tests (possible liver damage) * (Editor: If liver damage is listed at the same or higher frequency take this out.)

libido changes changes in sex drive*libido decreased decreased sex drive*libido increased increased sex drive*lichen planus skin rash*lichenoid skin sores*lichenoid dermatitis severe skin rashlichenoid keratosis change of skin color*light reflex absent (Editor: Delete this no matter what.)lightheadedness lightheadedness*limb ischemia reduced blood supply to the arms and legslimb pain arm/leg pain*lip ulceration lip blisters/sores*

lipase increasedabnormal digestive blood test (possible inflammation of the pancreas)*

lipids decreased (Editor: Delete no matter what.)lipomas fatty lumps*livedo reticularis change of skin color*liver abscess pus-filled areas in the liverliver damage liver damage

liver enzymes increased


liver failure liver failure

liver function abnormalabnormal liver function (AU: What is specifically meant by liver function abnormal?)



liver function test abnormality


liver function test changes


liver function tests abnormal


liver function tests increased


llisteriosis


local exfoliation skin peeling*

local ulceration if extravasatedtissue death at the injection site caused by drug leakage

logorrhea excessive talking*loose stools loose stools*

loss of bone mineral densityloss of bone strength (possible broken bones)*

loss of consciousness loss of consciousness

loss of deep tendon reflexesloss of deep tendon reflexes (possible weakness)

loss of sexual functionloss of sexual function (AU: What is specifically meant by loss of sexual function?)

loss of sphincter control inability to control bowel movements loss of taste loss of taste*loss of teeth tooth losslow birth weight low birth weight



lower respiratory tract disorders

disorders of the lungs (AU: What is specifically meant by lower respiratory tract disorders?)

lung crackles difficulty breathing*

lung disorderlung disorder (AU: What is specifically meant by lung disorder?)

lung edema fluid in the lung (possible difficulty breathing) lung fibrosis lung damage (possible difficulty breathing)

lung infiltration

lung inflammation/infection (Editor: Delete if any lung problems such as pneumonia or difficulty breathing are listed.)

lung toxicitieslung damage (AU: What is specifically meant by lung toxicities?)

lupus lupus (an immune system disease)

lupus-like syndromecondition that looks like lupus (an immune system disease)

LVEF decreased severe heart problemslymphadenitis inflamed lymph nodes*lymphadenoma lymph node swelling*lymphadenopathy lymph node swelling*lymphadenosis lymph node swelling* lymphangitis inflamed lymph nodes*lymphedema lymphedema (swelling of arms/legs/torso)

lymphedema-related fibrosistissue scarring from long-term lymph fluid blockage

lymphocele abnormal collection of lymph fluid*

en


lymphocytosisincrease in infection-fighting cells* (AU: Is lymphocytosis directly linked to the drug?)

lymphoma

(Study drug) may cause you to develop another type of cancer (such as lymphoma, a type of lymph node cancer).



lymphopenia

(Insert drug name) may cause low blood counts (white blood cells). A low white blood cell count increases your risk of infection (such as pneumonia and/or severe blood infection). Infections may occur anywhere and become life-threatening. (AU: Does this agent cause a site-specific infection that should be included?) Symptoms of infection may include fever, pain, redness, and difficulty breathing.

lymphoproliferative disease increase in white blood cellslymphoproliferative disorders increase in white blood cellsmacrocytosis enlarged red blood cells*macroglossia swollen tongue*

macular edemaswelling under the central part of the retina (possible vision loss)

macular rash skin rash* macular retinitis inflammation inside the eyemaculopapular skin rash*maculopapular rash skin rash* maculopathy eye damage causing vision problems

malabsorption syndromeinability to process food due to stomach and/or intestinal damage

malaise fatigue/lack of energy*

malignancy (Study drug) may cause you to develop another type of cancer.

malignant hyperpyrexia fever

malignant hypertensionvery high blood pressure (possible organ damage)

malignant hyperthermiaserious reaction to anesthesia, causing muscle tightening and fever AU

malignant melanoma

(Study drug) may cause you to develop another type of cancer (such as malignant melanoma, a type of skin cancer).

malignant testicular neoplasm

(Study drug) may cause you to develop another type of cancer (such as malignant testicular neoplasm, a cancerous tumor in the testicle).

malignant tumors

(Study drug) may cause you to develop another type of cancer (such as cancerous tumors).

maniamood disorder with extremes of happiness and sadness



manic reactionmood disorder with extremes of happiness and sadness

marrow damage


marrow fibrosis with collagenbone marrow failure due to abnormal tissue growth

marrow hypoplasia


masculinization of femaledevelopment of male features in females (such as enlarged breasts)*

mastalgia breast pain*

mastitis


medicinal taste abnormal taste*megacolon enlarged bowel (possible abdominal pain)

megaloblastic anemia


melanocytic naevus skin moles*

melanoma

(Study drug) may cause you to develop another type of cancer (such as melanoma, a type of skin cancer).

melena tarry stoolmemory decreased memory lossmemory difficulties memory lossmemory impairment memory loss

meningismus

inflammation of the membranes around the spinal cord and brain (possible headache and/or coma)



meningitis


meningoencephalitis

inflammation of the membrane around the spinal cord and brain (possible headache and/or coma)

menopause menopause* menorrhagia heavy menstrual bleedingmenstrual complaints changes to the menstrual cycle*menstrual disorder changes to the menstrual cycle*menstrual irregularities changes to the menstrual cycle*mental confusion confusion*mental depression depression* mental impairment mental difficulty mental status change mental status changementation impaired mental status changemesenteric ischemia decreased supply of blood to the abdomen mesenteric venous occlusion vein blockage in the abdomen

metabolic acidosisabnormal blood acid/base balance (possible organ damage)

metabolic acidosis (hyperchloremia nonanioabnormal blood acid/base balance (possible organ damage)

metabolic alkalosisabnormal blood acid/base balance (possible organ damage)

metallic taste abnormal taste*

methemoglobinemiaproblems with blood carrying oxygen (possible blue skin color)

metrorrhagia uterine and/or vaginal bleedingMI heart attack

microalbuminuria


microangiopathic hemolytic anemia destruction of red blood cells



microangiopathic hemolytic anemia with thr

(Drug name) may cause destruction of red blood cells and platelets. You may have problems with bleeding and/or bruising. You may have fatigue and shortness of breath. You may need a blood transfusion if a problem with bleeding occurs.

micturition difficulty difficulty urinatingmicturition frequency frequent urination* migraine migraine*milia white skin bumps*miliaria skin rash*miosis eye pupils getting smaller*miscarriage miscarriage mitral valve regurgitation heart valve leak*

moniliasis


monoparesis weakness of an arm or legmood alterations mood swings*mood changes mood swings*mood disturbance mood swings*mood elevated mood swings*

mood problemsmood problems (AU: What is specifically meant by mood problems?)

mood swings mood swings*

moon facebuild-up of fat in the face (Editor: Delete if Cushing's is listed.)

motility disorder

digestive disorder (AU: Would "motility disorder" be either constipation or diarrhea? Editor: For Capecitabine, take this AE out.)

motor difficulties

muscle weakness due to nerve damage or muscle problems (AU: Are motor difficulties due to a nerve problem or a muscle problem? Editor: For Vincristine Sulfate, take this AE out)

motor dysfunction uncontrolled movementsmotor neuropathy nerve damage (affecting movement)



mouth hemorrhage

bleeding in the mouth (AU: Is mouth hemorrhage due to low platelet count or a direct effect of the drug?)

mouth ulcer mouth blisters/sores*mouth ulceration mouth blisters/sores*mouth/tongue discoloration mouth/tongue discoloration *

mucormycosis


mucosal inflammation mouth blisters/sores*

mucositismouth blisters/sores (possible difficulty swallowing)*

multiorgan hypersensitivitylife-threatening allergic reaction (such as difficulty breathing, low blood pressure, and/or organ failure)

multiple sclerosis

multiple sclerosis (disorder of the central nervous system, causing motor difficulties) (AU: Can this drug specifically cause multiple sclerosis? Have the symptoms of this been covered?)

multiple sclerosis aggravated worsening of existing multiple sclerosis multisystem organ failure failure of multiple organs

mural thrombosisblood clots in the heart (possible organ damage such as stroke and/or heart attack)

muscle cramps cramps*

muscle enzyme increased

abnormal blood test (AU: What symptom(s) might occur if the muscle enzyme is increased?)

muscle mass loss loss of muscle* muscle rigidity stiffness*muscle spasm muscle spasms*muscle tightness muscle tightness*muscle wasting loss of muscle*musculoskeletal discomfort muscle and/or bone pain*musculoskeletal pain muscle and/or bone pain*musculoskeletal stiffness muscle and/or bone stiffness*mutism anxiety disorder causing inability to speak


Medical Term Lay Lanuguagemyalgia muscle pain*myasthenia muscle weakness*

myastheniaimmune response that causes the body to attack itself (causing muscle weakness)

myasthenia gravis immune response (causing muscle weakness) myasthenic syndrome muscle weakness*

mycobacterium avium complex infection


mydriasis pupil dilation (possible light sensitivity)*

myelodysplastic syndrome

decreased bone marrow function (possible

leukemia) (Editor: Keep this if low blood cell counts

is not already included.)

myelofibrosisbone marrow failure due to abnormal tissue growth

myeloproliferative syndrome

(Study Drug) may cause you to develop another type of cancer (such as myeloproliferative syndrome, a type of bone marrow cancer).

myelosuppression



Medical Term Lay Lanuguagemyocardial hemorrhage bleeding into the heart musclemyocardial hypertrophy heart damagemyocardial infarction heart attack

myocardial infection


myocardial ischemia decreased blood supply to the heart myocardial necrosis death of heart tissue myocardial rupture tearing of the walls of the heartmyocarditis heart inflammationmyoclonus muscle twitching*myopathy muscle damage causing weakness*myopia nearsighted vision myositis muscle inflammation*myotonus prolonged muscle spasm

myxedemathyroid gland failure (possible weight gain, heart failure, and/or coma)

nail banding nail changes *nail bed lesion/bleeding bleeding and/or lesions on the nail bednail changes nail changes* nail disorder nail changes* nasal congestion stuffy nose*nasal dryness dryness in the nose*nasal septum perforation abnormal hole inside the nose

nasopharyngitis


nausea nausea*neck pain neck pain*neck rigidity stiff neck* neck stiffness stiff neck*


Medical Term Lay Lanuguagenecrosis tissue death

necrotic changes and ulceration following etissue death at the injection site caused by drug leakage

necrotizing angiitisblood vessel damage (possible blockage of blood flow)

necrotizing colitisdecreased blood flow to part of the bowel (possibly causing tissue death)

necrotizing leukoencephalopathydecreased brain function (possible paralysis and/or coma)

negative nitrogen balance due to protein cabody-wide loss of proteins (possible weakness and/or swelling)

neoplasmgrowth of a new tumor (AU: Is this an infection or the development of another cancer?)

nephritiskidney inflammation* (AU: What symptoms would be seen?)

nephrogenic diabetes insipiduskidney damage causing abnormal thirst and excessive urination

nephrogenic fibrosing dermopathy (NSF/NFhardened skinnephrolithiasis kidney stones*

nephrotic syndromedecreased kidney function (possible kidney failure)

nephrotoxicitydecreased kidney function (possible kidney failure)

nerve compression

nerve damage due to pressure on the nerves (possible loss of function in area controlled by the nerves)

nerve palsy (facial) paralysis (face)

nerve palsy (oculomotor)eye movement problems (possible double vision)

nervousness nervousness*

neural toxicitynerve damage (AU: What neural toxicity does the drug specifically cause?)

neuralgia nerve pain*

neuritisinflammation of nerves (possible pain and/or loss of motor or sensory function)

neuritis (peripheral)inflammation of nerves (possible pain and/or loss of motor or sensory function)

neuroencephalopathydecreased brain function (possible paralysis and/or coma)

neurogenic bladder nerve damage affecting the bladder

neuroleptic malignant syndrome

neuroleptic malignant syndrome (possible high blood pressure, muscle stiffness, and/or fever)



neurologic toxicity

nervous system damage (AU: What neurologic toxicity does the drug specifically cause?)

neuromyopathy

disease of muscles and nerves (AU: Is this nerve damage or muscle damage either use perhepaher neuropathy or mucle problems?)

neuropathic pain nerve damage (causing pain)

neuropathynerve damage (loss of motor or sensory function)

neuroretinitis inflammation inside the eyeneurosensory hyperacusis hearing loss

neurosispsychological or behavioral disorder causing anxiety

neurotoxicity

nervous system damage (AU: What neurotoxicity does the drug specifically cause?)

neutralizing antibodies

immune reaction (AU: Does the antibody reaction cause loss of drug function, organ damage, or either?)

neutropenia


neutropenic colitis

infection of the colon due to low white blood cell counts (Editor: Delete the if low white counts is already listed.)

neutropenic enterocolitis (typhlitis)

inflammation of the intestines due to low white blood cell counts (Editor: Delete the if low white counts is already listed.)

neutropenic fever

fever due to low white blood cell counts (Editor: Delete the if low white counts is already listed.)

neutropenic fever-sepsis

severe life-threatening infection (possible low blood pressure, kidney failure, and/or heart failure)



neutropenic infection

infection due to low white blood cell counts (Editor: Delete the if low white counts is already listed.)

neutropenic sepsis


neutrophil count decreased


neutrophilic eccrine hidradenitis


night sweats night sweats*nightmares nightmares*nocturia urination at night*nonconvulsive status epilepticus seizure

non-Hodgkin's lymphoma

(Study Drug) may cause you to develop another type of cancer (such as non-Hodgkin's lymphoma, a type of lymph node cancer).

nonprotein nitrogen increasedabnormal blood test (possible kidney damage)*

nonspecific gastrointestinal symptomsdigestive system problems* (Editor: Delete if there are any other GI problems listed.)

nonspecific QT changes abnormal EKG*

nonspecific urogenital findings(AU: What is specifically meant by "nonspecific urogenital findings"?)

nystagmus eye twitching* obesity obesity*


Medical Term Lay Lanuguageobsessive-compulsive disorder obsessive-compulsive disorder obstipation constipation*

ocular (lens) changes

changes to the eye lens (possible vision problems)* (AU: What specially could ocular (lens) changes cause?)

ocular discomfort eye pain*ocular hyperemia red eyes*

ocular hypertensionincreased pressure in the eye (possible pain and/or blurry vision)*

ocular hypotonyseverely decreased pressure in the eye (possible eye pain)*

ocular inflammation eye inflammation* ocular pain eye pain*ocular pruritus itchy eyes*

ocular surface diseaseeye disease (AU: What is specifically meant by ocular surface disease?)

ocular vascular disordereye blood vessel disorder (AU: What does vascular disorder specifically cause?)

oculobulbar myasthenia gravisimmune response (causing muscle weakness in the eyes)

oculogyric crisis eye twitching

oculomotor nerve palsyeye movement problems (possible double vision) paralysis of an eye muscle

oculomucocutaneous reactionsdamage to the lining of the eyes (possible dry eyes, scarring, pain, and/or redness)

odynophagia painful swallowing*

OHSSenlarged ovaries (possible pain, weight gain, vomiting, and/or difficulty breathing)

oligohydrosis absent or decreased ability to sweatoligohydrosis absent or decreased ability to sweatoligospermia low sperm countoliguria decreased urine output onychoclasis breaking of nails*

onycholysis


ophthalmic gritty sensation feeling of dust in the eye*



ophthalmic herpes


ophthalmoplegia eye muscle weakness

optic atrophydamage to an eye nerve (possible vision changes)

optic disc edema swelling in the eye (possible vision damage)

optic disc pallor/atrophydamage inside the eye (possible vision changes)

optic nerve damage damage to an eye nerveoptic neuritis inflammation of an eye nerveoptic neuropathy nerve damage (affecting the eye) oral and gastric irritation mouth and stomach irritation*oral blistering mouth blisters/sores*

oral candidiasis


oral discomfort mouth pain*

oral moniliasis




oral mucosal petechiae

small red or purple spots in the mouth* (Editor: Delete if low platelet count is already listed.)

oral pain mouth pain*

oral thrush


orchitisinflammation of the testicles (possible pain and/or redness)

organ perfusion decreased

decreased blood flow to an organ (possible impaired organ function or organ failure) (AU: Is "organ perfusion decreased" covered by another AE?)

oropharyngeal drying/irritation dry, irritated throat* oropharyngeal edema swollen throatoropharyngeal pain mouth and throat pain* orthopnea difficulty breathing

orthostatic hypotensionlow blood pressure (possible dizziness/fainting)

osmolar gap increased(AU: What causes osmolar gap increased? Editor: This can be removed from Mannitol.)

osteoarthritis joint pain and stiffness*

osteochondrosis

damage to the growing part of the bones (Editor: Take out unless a pediatric study. Be sure to add this to the database notes for the drug.)

osteomyelitis


osteonecrosis bone destruction



osteopeniaweakening of bone strength (possible broken bones)

osteoporosis loss of bone strength (possible broken bones)otalgia ear pain*

otitis externa


otitis media


ototoxicity hearing lossovarian cysts ovarian cysts (fluid-filled lump)*

ovarian failurefailure of the ovaries to produce hormones (possible stopped menstrual cycle)

ovarian hyperstimulation syndromeenlarged ovaries (possible pain, weight gain, vomiting, and/or difficulty breathing)

ovarian suppression decreased function of the ovaries overdiuresis increased urine output oversedation sedation*pain pain*pain along lumbar nerves nerve pain in the back*pain in extremity arm/leg pain*painful erection painful erection* painful eye eye pain*pallor pale skin*

palmar-plantar erythrodysesthesiahand-foot syndrome (palms of hands/soles of feet having pain, swelling, and blistering)

palpitation irregular heartbeat



palsy

(AU: Do you mean paralysis or a movement disorder? Editor: For Ifosfamide, take this AE out.)

pancreatic atrophydecreased pancreas size (possible diabetes, diarrhea, difficulty absorbing nutrients)

pancreatic enzymes abnormal

abnormal pancreas tests (Editor: if pancreas damage is listed at the same or higher frequency take this out)

pancreatic pseudocyst fluid-filled sac in the pancreas*

pancreatitisinflammation of the pancreas (possible abdominal pain)

pancytopenia


panhypopituitarismpituitary gland failure (possible endocrine gland abnormality)

panic panic panic attacks panic attacks*

panniculitis inflammation of the fatty layer under the skin

papillary necrosis death of kidney tissue (possible kidney failure)

papilledema swelling of the eye nerve (possible vision loss)

papilloma non-cancerous or pre-cancerous skin lesions*papular rash skin rash* papules skin bumps*paradoxical dizziness dizziness



paradoxical excitementunusual excitement*( AU: How would you define paradoxical excitement?)

paradoxical increased sensitivity of emotionmental status changeparalysis paralysisparalytic ileus paralysis of the intestines paraneoplastic pemphigus painful blisters

paraneoplastic syndrome(Editor: This is not a side effect, take this out no matter what.)

paranoia paranoia (feeling of fear and/or mistrust)paranoid reaction paranoia (feeling of fear and/or mistrust)paraplegia paralysis (both legs)

parathesiaabnormal sensation (such as pins and needles)

parathyroid disorder(AU: What is specifically meant by "parathyroid disorder"?)

paresis paralysis

paresthesiaabnormal sensation (such as pins and needles)

paresthesia of extremitiesabnormal sensation (such as pins and needles)

parkinsonian syndromesymptoms of Parkinson's disease (such as abnormal movement)*

paronychia


paronychial inflammation nailbed inflammation (possible pain/infection)*

paronychial inflammation nailbed inflammation (possible pain/infection)parosmia abnormal sense of smell*parotid gland pain pain (cheek)parotid pain throat pain*

parotitisinflammation of the salivary glands on either side of the face

paroxysmal nocturnal dyspnea heart failure partial thromboplastin time increased increased risk of bleedingpathologic fracture of long bones brittle/broken bones



pathological fracturebroken bone(s) (Editor: Delete this no matter what.)

peeling of palms skin peeling (palms of the hands)peeling of soles skin peeling (soles of the feet)peliosis hepatis blood-filled areas in the liver

pelvic fibrosis

pelvic scarring* (AU: Where would the scarring in the pelvis occur? Editor: For Leuprolide Acetate, take out this AE.)

pelvic pain pelvic pain*pemphigus painful blisters

penile/testis disorder

(AU: What specifically does "penile/testis disorder" relate to? Editor: For Leuprolide Acetate, take this AE out.)

peptic ulcer stomach ulcer

perforation of the small and large intestinehole in the intestines (possibly leaking contents into the abdomen)

performance deteriorationfatigue and/or weakness (Editor take this out if already covered.)

periarteritis nodosa damaged arteries

pericardial effusion build-up of fluid in the tissue around the heart

pericarditisinflammation of the tissue around the heart (possible chest pain)

peridiverticular abscess


periodontal abscess


periodontal disease gum disease*periodontitis gum disease*


Medical Term Lay Lanuguageperiorbital edema swelling (around the eyes)peripheral edema swelling (arm/leg)*

peripheral gangrene

decay of body tissue (Editor: If this is a procedure leave in. Editor: For Aldesleukin, take this AE out.) (AU: Does the drug specially cause peripheral gangrene?)

peripheral ischemia reduced blood supply to the arms and legs

peripheral neuritisinflammation of nerves (possible pain and/or loss of motor or sensory function)

peripheral neuropathynerve damage (possible numbness, pain, and/or loss of motor function)

peripheral neurotoxicitynerve damage (possible numbness, pain, and/or loss of motor function)

peripheral swelling swelling (arm/leg)*

peripheral vascular disease blood vessel disorder (possible tissue death)peripheral vascular disorder decreased blood circulation

peripheral vasculitisblood vessel inflammation (possible bleeding and/or bruising)*

peripheral vasodilation flushing*perirectal abscess pockets of pus in or near the anusperitonitis abdominal wall inflammation*peritonsillar abscess pus in the throat*

perivasculitisblood vessel inflammation (possible bleeding and/or bruising)

persistent anesthesia prolonged numbnesspersonality change personality change*

personality disorder

personality disorder (abnormal thoughts and actions) (AU: Can this drug cause personality disorder?)

petechiaetiny dots on the skin (Editor: Delete if low platelet count is already listed.)

Peyronie's diseaseabnormal bending of the erect penis (possible pain)

pharyngeal erythema throat redness*pharyngeal pain throat pain* pharyngitis sore throat*pharyngolaryngeal pain throat pain* phlebitis vein inflammation*

phlebitis superficialblood clots in a vein (possible pain, swelling, and/or redness)

phlebosclerosis vein hardening*photoallergic reactions skin sensitivity to sunlight or lamps*photophobia eye sensitivity to light*


Medical Term Lay Lanuguagephotopsia bright spots in the vision*photosensitivity skin sensitivity to sunlight or lamps* photosensitizing reactions skin sensitivity to sunlight or lamps* phototoxicity skin sensitivity to sunlight or lamps*

pigmentary retinopathy damage inside the eye (possible blindness)pigmentation change change of skin color*pigmentation disorder change of skin color*pigmentation of nail beds nail changes*piloerection goosebumps* pitting edema swelling*

pituitary apoplexypituitary gland failure (possible hormone imbalance)

pituitary neoplasm pituitary gland tumor (possible abnormal hormones levels)

pityriasis rosea skin rash*

plaque erosions

blood vessel damage (possible blockage of blood flow) (Editor: Keep if this is a procedure/surgery. Take out of Methotrexate.) (AU: Does the drug specifically cause plaque erosions?)

platelet aggregation abnormal abnormal blood clotting

platelet count increasedhigh blood platelet count (possible increased clotting)

pleocytosisabnormally high number of cells in the body* (AU: Which cells is pleocytosis relating to?)

pleural disorder(AU: What is specifically meant by pleural disorder?)

pleural effusion build-up of fluid around the lungs pleurisy lung inflammation causing chest pain*pleuritic pain lung inflammation causing chest pain* pleuritis lung inflammation causing chest pain*pneumatosis cystoides intestinalis air-filled cysts in the intestines

pneumatosis intestinalisgas in the intestines (possible intestinal damage)

pneumobilia gas in the bile tract in the liver (possible pain)



pneumonia


pneumonitislung inflammation (possible difficulty breathing)

pneumothorax collapsed lung (possible difficulty breathing)

pO2 increasedincreased oxygen levels in the air that is breathed in* (Editor: Take this out.)

pollakuria frequent urination*polyarteritis artery inflammation* polyarthralgia joint pain* polyarticular arthritis joint inflammation and swelling*

polycythemiahigh red blood cell count (possible headache, dizziness, and/or stoke)

polydipsia thirst*polymyalgia rheumatica muscle pain*polymyositis muscle inflammation and weakness

polyneuropathydamage to many nerves (loss of motor or sensory function)

polyserositis inflammation around the abdomen and lungs* polyuria frequent urination*porphyria cutanea tarda blistering skin rash

portal fibrosisscarring of a vein to the liver (possible liver damage)

portal hypertensionhigh blood pressure in a vein to the liver (possible liver damage)

portal vein flow

abnormal blood flow to the liver (possible liver damage) (AU: What is meant by portal vein flow?)

portal vein thrombosisblood clots in a vein to the liver (possible liver and/or digestive system damage)

positive ANAabnormal blood test (possible immune disorder such as lupus)

positive Coombs' test abnormal blood test (possible anemia) positive Coombs' test without hemolysis abnormal blood test (possible anemia)



posterior reversible encephalopathy syndrobrain injury (possible headache, confusion, seizures, and/or vision loss)

posterior subcapsular cataracts cataracts (clouding of the lens of the eye)postinjection flare joint pain*postnasal drip runny nose *postoperative pain pain*postprocedural pain pain*

postural hypotensionlow blood pressure (possible dizziness/fainting)

potassium losslow blood levels of potassium (possible muscle cramps)

precocious puberty

early puberty (Editor: Take out unless a pediatric study. Be sure to add this to the database notes for the drug.)

precordial pain chest painpremature ejaculation premature ejaculation* premature ejaculation premature ejaculation*

premature epiphyseal closure

stunted bone growth (Editor: Take out unless a pediatric study. Be sure to add this to the database notes for the drug.)

premature ventricular beats irregular heartbeatpremature ventricular contractions (PVC) irregular heartbeat priapism painful, abnormally long-lasting erectionPrinzmetal's angina chest pain due to heart trouble

procedural complicationcomplication from a medical procedure* (Editor: Delete this no matter what.)

proctalgia anal and/or rectal pain*proctitis anal and/or rectal inflammation*productive cough cough*

progressive CNS deteriorationworsening problems with brain function (Editor Delete no matter what.)

progressive multifocal leukoencephalopathy

The study drug may cause progressive multifocal leukoencephalopathy (PML). PML is brain damage that is likely to result in paralysis and/or coma, which may be permanent. PML can also lead to death.

prolactin hormone secretion abnormalityabnormal hormone production (possible breast milk production)*

prolactin levels increasedabnormal hormone production (possible breast milk production)*

proliferative glomerular nephritisdecreased kidney function (possible kidney failure)

prolongation of PT/INR increased risk of bleedingprolongation of PT/INR increased risk of bleedingprolonged pregnancy and labor pregnancy and labor may take longer*


Medical Term Lay Lanuguageprolonged QTc interval abnormal EKG*proptosis bulging eye*

prostate cancer (high grade)

(Study drug) may cause you to develop another type of cancer (such as prostate cancer).

prostate pain prostate pain*prostatic acid phosphatase decreased abnormal prostate blood test*prostatic acid phosphatase increased abnormal prostate blood test*

prostatic carcinoma

(Study drug) may cause you to develop another type of cancer (such as prostate cancer).

prostatic disorder(AU: What is specifically meant by "prostatic disorder"?)

prostatic hyperplasia enlarged prostate (possible inability to urinate)prostatitis prostate inflammation*

protein catabolismbody-wide loss of proteins (possible weakness and/or swelling)

protein wasting gastroenteropathylow blood levels of albumin (possible swelling, weakness, and/or fatigue)

proteinuria


prothrombin decreased increased risk of bleedingprothrombin time increased increased risk of bleedingprothrombin time prolonged increased risk of bleedingprothrombin times prolonged increased risk of bleeding pruritic rash itchy skin rash*pruritus itching*PSA increased abnormal prostate blood test* pseudomembraneous colitis inflammation of the intestines*

pseudomonal lung infection


pseudo-obstruction abdominal cramping, pain, and swelling

pseudoparkinsonismsymptoms of Parkinson's disease (such as abnormal movement)*



pseudotumor cerebri

increased pressure in the skull (possible headache, vision changes, and/or mental status changes)

psoriasisred, dry, scaly patches of thickened skin (psoriasis)

psoriasis exacerbation worsening of existing psoriasis

psychomotor retardationmental and physical changes (such as memory loss and impaired thinking)

psychomotor slowingmental and physical changes (such as slowing of motor function and thinking)

psychosis psychosis (loss of contact with reality)psychotic reaction psychosis (loss of contact with reality)psychotic symptoms psychosis (loss of contact with reality)

PTLD (Post-Transplant Lymphoproliferative

(Study drug) may cause you to develop another type of cancer (such as post-transplant lymphoproliferative disorder, a type of lymph node cancer).

ptosis drooping eyelidPTT increased increased risk of bleeding

pulmonary changeslung changes (possible shortness of breath) (AU: What is meant by pulmonary changes)

pulmonary collapse collapsed lung (possible difficulty breathing)

pulmonary congestion

lung congestion (possible difficulty breathing)* (AU: What is meant by pulmonary congestion?)

pulmonary congestion fluid in the lungs (possible difficulty breathing)

pulmonary edema fluid in the lung (possible difficulty breathing)

pulmonary emboliblockage in the lung (possible pain and/or shortness of breath)

pulmonary embolismblockage in the lung (possible pain and/or shortness of breath)

pulmonary embolusblockage in the lung (possible pain and/or shortness of breath)

pulmonary fibrosis lung damage (possible difficulty breathing)

pulmonary hemorrhage

bleeding in the lungs and/or airways (AU: Is pulmonary hemorrhage due to low platelets or due to lung problems?)

pulmonary hypertension

increased blood pressure in the lungs (possible difficulty breathing and/or heart failure)



pulmonary infection


pulmonary infiltrates lung inflammation

pulmonary masslung tumor (AU: Is this an infection or the development of another cancer?)

pulmonary nodule

abnormal tissue in the lungs (AU: What is causing pulmonary nodule? Editor: For Octreotide, take this AE out.)

pulmonary thromboembolismblood clots in the lung (possible difficulty breathing)

pulmonary/larynx edema swelling of the vocal cords and lungs

pure red cell aplasia

decreased bone marrow function and inability to make red blood cells (Editor: Delete if decreased if bone marrow function is listed.)

purpura

spots on the skin (caused by low platelets) (Editor: Delete if low platelet count is already listed.)

pustular rash blistering skin rashpustule blisterspustules blisters

pyelonephritis


pyoderma gangrenosum lesions due to skin infection pyogenic granuloma skin lesions (possible bleeding)* pyrexia fever



pyuria


QT prolongation abnormal EKG*QTc prolongation abnormal EKG*quadriparesis paralysis (below the neck)quadriplegia paralysis (below the neck)

radiation injuryradiation injury (AU: Is the radiation injury "radiation recall"?)

radiation myelopathy

damage to the spinal cord due to radiation (possible paralysis, weakness, and/or abnormal sensation) (AU: Does this drug cause radiation myelopathy as a form of radiation recall?)

radiation pneumonitisinflammation of the lungs related to radiation (Editor: delete if not a radiation study)

radiation pneumonitis with concurrent radia lung damage at the site of prior radiation

radiation recallsevere sunburn-like rash at site of previous radiation (called radiation recall)

radiation recall (esophagitis)soreness and inflammation of the throat or esophagus at a site of prior radiation therapy

radiation recall pneumonitis lung damage at the site of prior radiation

radiographic pulmonary infiltrateslung inflammation (possible difficulty breathing)

rales difficulty breathing*rash skin rash*rash erythematous skin rash*

Raynaud's diseaseblood vessel disorder causing painful, cold, numb, and discolored fingers and/or toes

Raynaud's phenomenonblood vessel disorder causing painful, cold, numb, and discolored fingers and/or toes



rebound thrombocytopenia


rectal bleeding

bleeding in the rectum (AU: Is rectal bleeding due to low platelets or a direct effect of the drug?)

rectal disorder

(AU: What is specifically meant by "rectal disorder"? Editor: Remove this AE for Tacrolimus.)

rectal hemorrhage

bleeding or blood in the stool (AU: Is rectal hemorrhage due to low platelets or due to GI irritation.)

rectal stenosis narrowing of the rectum redness, irritation, and induration injection site swelling, pain, and/or heat*

reflex sympathetic dystrophy

increased sensitivity to pain (possible burning, sweating, and/or swelling of the arms and legs)

refraction disorder blurry visionregional ileitis inflammation of the intestines*regurgitation vomiting*

renal artery thrombosisblood clot in an artery to the kidney (possible kidney damage or loss of function)

renal calculus kidney stones*renal complications decreased kidney functionrenal cysts kidney cysts renal deterioration decreased kidney function

renal disorder

kidney disorder* (AU: What is specifically meant by renal disorder? For Busulfan, use kidney disorder.))

renal dysfunction decreased kidney functionrenal failure kidney failure renal impairment decreased kidney function

renal infarct death of kidney tissue (possible kidney failure)renal insufficiency decreased kidney functionrenal mass abnormal growth in the kidneysrenal rickets bone pain*

renal toxicitykidney damage (AU: What is meant by renal toxicity?)

renal tubular acidosisabnormal blood acid/base balance (possible organ damage)



renal tubular necrosis death of kidney tissue (possible kidney failure)

respiratory acidosisabnormal blood acid/base balance (possible organ damage)

respiratory alkalosisabnormal blood acid/base balance (possible organ damage)

respiratory arrest stopped breathing

respiratory bleeding

bleeding in the lungs and/or airways (AU: Is respiratory bleeding due to low platelets or due to lung problems?)

respiratory depression difficulty breathingrespiratory disorder difficulty breathingrespiratory distress difficulty breathingrespiratory distress syndrome difficulty breathingrespiratory failure difficulty breathing

respiratory infection


respiratory insufficiency difficulty breathing

respiratory moniliasis


respiratory syncytial virus

The drug may cause an increased risk of infection, such as pneumonia. This infection may occur anywhere.



respiratory tract (lower) infection


restless leg syndrome restless leg syndrome*restlessness restlessness*

reticulocytes decreased


retinal artery thrombosis blood clots inside the eye (possible blindness)

retinal changesvision problems (AU: What are the specific retinal changes?)

retinal degeneration retinal degeneration (possible blindness)

retinal detachment detached retina (possible partial blindness)retinal disturbances damage to the retina (possible vision loss)

retinal disturbances (AU: What is specifically meant by retinal disturbances?)

retinal hemorrhage

bleeding in the eye (AU: Is retinal hemorrhage due to low platelet counts or a direct effect of the drug?)

retinal ischemiadecreased supply of blood inside the eye (possible blindness)

retinal occlusionblocked blood vessel in the retina of the eye (possible blindness)

retinal vein occlusion blood clot inside the eye (possible blindness)

retinal vein thrombosis blood clot inside the eye (possible blindness)retinitis inflammation inside the eye

retinoic acid syndrome


retinoic acid-acute promyelocytic leukemia



Medical Term Lay Lanuguageretinopathy damage to the retina (possible vision loss) retrograde ejaculation passing of semen into the bladder

retroperitoneal hemorrhage

bleeding in the abdomen (AU: Is this caused by low platelets or a direct effect of the drug?)

reversible posterior leukoencephalopathy s

brain injury that may be reversible (possible headache, confusion, seizures, and/or vision loss)

Reye's syndromeReye's syndrome (disorder that causes brain and liver damage)

rhabdomyolysisbreakdown of muscle tissue (possible kidney failure)

rheumatoid arthritisimmune response (causing joint, tissue, and organ damage)

rhinitis runny nose*rhinorrhea runny nose*rhinosinusitis runny nose*

rhonchi wheezing* (Editor: Take out no matter what.)

Richter's syndrome

(Study drug) may cause you to develop another type of cancer (such as Richter's syndrome, a type of aggressive lymphoma).

ricketsloss of bone strength (possible broken bones) *

right heart failure heart failureright ventricular pressure increased severe heart problemsrigors shivering* sagittal sinus thrombosis blood clots the brainsalivary hypersecretion increased saliva*salivation increased saliva*salpingitis inflammation of the fallopian tube

sarcoidosismulti-organ disease causing lesions, most often in the lungs (sarcoidosis)

sarcoma

(Study Drug) may cause you to develop another type of cancer (such as sarcoma, a type of cancer that can start in the soft tissue, bone, or other tissue).

scarring scarring*

sciaticapain shooting from the lower back to the thighs*

sclera discoloration (blue) change in color in the whites of the eyes*

scleral hemorrhage

bleeding in the eye (AU: Is scleral hemorrhage due to low platelet counts or a direct effect of the drug?)


Medical Term Lay Lanuguagescleritis eye inflammation*

sclerodermasevere hardened skin (possible difficult movement)

sclerosing cholangitis liver damage due to inflammationscotoma blind spotscrotal edema swelling of the scrotumseborrhea oily skin*

seborrheic keratosis non-cancerous or pre-cancerous skin lesions*

secondary acute myelogenous leukemia

(Study drug) may cause you to develop another type of cancer (such as secondary acute myelogenous leukemia, a type of blood cancer).

secondary cardiomyopathy heart failure

secondary malignancyThe study drug may cause you to develop another type of cancer.

secondary myleoproliferative syndrome

increased bone marrow function (possible stroke and/or increased clotting) (AU: Is this due to the drug or secondary leukemia?)

sedation sedation*seizure seizure

sensory disturbance(AU: What is specifically meant by sensory disturbance?)

sensory neuropathy nerve damage (loss of sensory function)

sepsis


septic shock


septic shock-like syndrome


septicemia




serotonin syndrome

high levels of serotonin (possible seizures, muscle breakdown, headache, fast heart rate, and/or shivering/sweating)

serotonin-induced fibrosis

high levels of serotonin (possible thickening of heart valves, lung arteries, and/or tissues in the abdomen)

serum albumin increased (Editor: Delete no matter what.)

serum bicarbonate decreased


serum bicarbonate increased


serum bicarbonate levels decreasedabnormal blood acid/base balance (possible organ damage)

serum chloride increasedincreased blood levels of chloride (possible kidney problems)*

serum creatinine increased


serum glucose decreased low blood sugarserum glucose increased high blood sugar (possible diabetes)

serum ionized calcium increased

high blood levels of calcium (possible altered mental status, weakness, and/or kidney damage) (Editor: If 3 or more, use general abnormal minerals)

serum iron decreasedlow blood levels of iron (possible low blood red cell counts and/or weak fingernails)

serum iron increasedhigh blood levels of iron (possible liver and/or pancreas damage)*

serum potassium decreased

low blood levels of potassium (possible weakness and/or muscle cramps) (Editor: If 3 or more, use "general abnormal minerals".)

serum sicknessimmune system reaction (possible organ damage)

serum sickness-like reactionsimmune system reaction (possible organ damage)

serum triglycerides increasedhigh blood levels of fat (possible heart disease and/or stroke)



severe cerebellar toxicity decreased brain function affecting movementsevere protein C deficiency increased risk of blood clottingsexual dysfunction sexual dysfunction*

SGOT


shock shock

SIADH


sialoadenitis


sick sinus syndrome irregular heartbeat

sickle cell crisissickle cell crisis in patients with sickle cell disease

side effects worsen with radiationside effects of the drug may worsen with radiation*

sinus arrest sudden stopping of the heart sinus arrhythmia irregular heartbeatsinus bradycardia slow heartbeatsinus congestion stuffy nose* sinus headache headache* sinus tachycardia fast heartbeat

sinusitis


SIRSbody-wide inflammation (AU: Is SIRS already covered by a different AE?)


Medical Term Lay Lanuguageskeletal hyperostosis unusual bone growth*skeletal muscle pain muscle pain*skeletal pain bone pain*skin "flare" at injection site injection site pain and/or inflammation*skin atrophy skin thinning*

skin cancer(Study drug) may cause you to develop another type of cancer (such as skin cancer).

skin carcinoma(Study Drug) may cause you to develop another type of cancer (such as skin cancer).

skin depigmentation lightening of skin*skin discoloration change of skin color*

skin disorderskin disorder (AU: What specific skin disorder(s) does this refer to?)

skin dystrophy skin damage* skin exfoliation skin peeling* skin freckling skin freckling*skin hypersensitivity allergic skin reactionskin hypertrophy thickened skin* skin laceration skin wound*skin lesion skin sores*

skin necrosisdeath of skin (AU: What is causing the skin necrosis?)

skin nodule skin bump*skin oily oily skin*skin pigment changes lightening of skin*skin pigmentation (slate gray) change of skin color*

skin sloughing of the palmar and plantar suskin peeling (palms of the hands/soles of the feet)

skin test reaction impairedskin tests (such as for TB) may not be accurate*

skin ulcer skin sores*skin ulceration skin sores*

skin/mucous membrane dryness

dryness of the skin and/or mucous membranes* (AU: What mucous membrane is dry?)

sleep apnea interrupted breathing while asleep*

sleep disorder(AU: What is specifically meant by sleep disorder?)

sleep disturbance difficulty sleeping*sleeplessness difficulty sleeping*

slipped capital femoral epiphysis

pain and/or loss hip joint function due to bone damage (Editor: Remove unless this is a surgery study.)


Medical Term Lay Lanuguagesloughing skin peeling*small bowel obstruction intestinal blockage

smell disorder

change in sense of smell (AU: Please clarify what is meant what is meant by smell disorder. Editor: For Testosterone, take this out.)

sneezing sneezing*

sodium retention

high blood levels of sodium (possible weakness and/or swelling) (Editor: If 3 or more, use general abnormal minerals)

soft tissue calcification hardened tissue*somnolence sleepiness* sore throat sore throat*speech problems speech problems

spinal cord compression

loss of feeling or movement due to pressure on the spinal cord (Editor: Remove unless this is a surgery study.)

spinal cord injuryloss of feeling or movement due to spinal cord damage

spinal epidural hematoma blood clot near the base of the spinal cord splenic infarction death of spleen tissue splenic rupture ruptured spleensplenomegaly enlarged spleenspondylitis inflammation of bone in the spine spontaneous abortion miscarriagespontaneous bacterial peritonitis infection in or around the abdomen

sputum increasedincreased mucus from the lungs* (Editor: Take this out.)

squamous cell carcinoma

(Study Drug) may cause you to develop another type of cancer (such as squamous cell carcinoma, a type of skin cancer).

ST segment depression abnormal EKG* staining of skin change of skin color*

staphylococcal infection




staphylococcus bacteremia


status asthmaticus severe, prolonged asthma episodestatus epilepticus continuous seizure steatorrhea greasy stool*steatosis fatty liver (possible liver damage)* stenosis of large arterial vessels of the brai strokesterility inability to have children*steroid myopathy muscle damage causing weakness*stertorous breathing loud breathing

Stevens-Johnson syndrome

very severe blistering skin disease (with ulcers of the skin and digestive tract) (Editor: if the drug also causes toxic epidermal necrolysis, combine as "very severe blistering skin disease (loss of large portion of skin and/or ulcers of the skin and digestive tract)")

stillbirths stillbirth stomach bloating abdominal swelling*

stomach disorder stomach disorder (AU: What is specifically meant by stomach disorder?)

stomatitismouth blisters/sores (possible difficulty swallowing)*

strabismus crossed eyesstreaking skin redness*

streptococcal bacteremia


striae stretch marks*stridor difficulty breathing*


Medical Term Lay Lanuguagestroke (ischemic) strokeST-segment increased abnormal EKG* ST-T wave changes abnormal EKG* stupor unresponsiveness* subarachnoid hemorrhage bleeding around the brainsubconjunctival hemorrhage bleeding into the whites of the eyes*subdural hematoma bleeding around the brainsubdural hematoma blood build-up on the surface of the brain subileus intestinal blockage

substance overdose overdose (Editor: Take out no matter what.)sudden death sudden death suicidal ideation suicidal thoughts suicide suicidesuicide attempt suicide attempt

sunburnskin sensitivity to sunlight or lamps (possible sunburn)*

superficial edema swelling*suppression of clotting factors increased risk of bleedingsupraventricular arrhythmia irregular heartbeat supraventricular extrasystoles extra heartbeatssupraventricular tachycardia fast heartbeat SVT fast heartbeat Sweet's syndrome skin condition with fever and skin lesionssyncope fainting synovitis joint inflammation and swelling*

systemic inflammatory response syndrome body-wide inflammation (AU: Is SIRS already covered by a different AE?)

systemic vasculitisblood vessel inflammation (possible bleeding and/or bruising)

tachyarrhythmia fast heartbeattachycardia fast heartbeat tachypnea fast breathing*

tamponadebuild-up of fluid around the heart (possible heart failure)

TASS



Medical Term Lay Lanuguagetaste alteration abnormal taste*taste disorder abnormal taste*taste disturbance abnormal taste*taste dysgeusia abnormal taste*taste perversion abnormal taste*tearing teary eyes*tearing increased teary eyes*telangiectasia dilated red blood vessels*temperature change sensation feelings of temperature changes*temperature intolerance temperature intolerance*

temporal arteritis

artery inflammation in the side of the head (possible headache)* (Editor: Take this out if there is already artery inflammation.)

tendinous contractureshortened tendon (decreased range of joint motion)*

tendon rupture tendon tear

tendonitis inflammation of the tendons (possible pain)*tenesmus urgent need to pass stool*

tenosynovitis inflammation of the tendons (possible pain)*tension tension*testicular atrophy decreased testicle size and functiontesticular pain pain in the testicles*testicular suppression decreased testes function testosterone levels decreased low levels of testosterone*the blood (possible weakness, swelling, fatigue, low blood pressure, organ failure, heart prothermal dysregulation difficulty maintaining body temperaturethick saliva thick saliva*

thickening of bronchial secretions increased thickness of secretions in the lung*thinking abnormality difficulty thinking*third-degree heart block slow heartbeatthirst thirst*throat irritation sore throat*throat irritation sore throat*

thrombocythemiahigh blood platelet count (possible increased clotting)

thrombocytopenia




thrombocytopenic purpura (TTP)multiple blood clots (possible organ dysfunction and/or failure)

thrombocytosishigh blood platelet count (possible increased clotting)

thromboembolismblood clots (AU: Is this in the artery or the vein?)

thrombophlebitisblood clots in a vein (possible pain, swelling, and/or redness)

thromboplastin decreased increased risk of bleedingthromboplastin increased increased risk of blood clottingthromboplastin time increased increased risk of bleeding

thrombosisblood clots (AU: Is this in the artery or the vein?)

thrombotic microangiopathyabnormal blood clotting in small blood vessels (possible stroke and/or other organ damage)

thrombotic stroke stroke

thrombotic thrombocytopenic purpuramultiple blood clots (possible organ dysfunction and/or failure)

thyroid disorder(AU: What is specifically meant by thyroid disorder?)

thyroiditisinflammation of the thyroid gland (possible tenderness in the neck)

TIA temporary stroke symptomstingling sensation tingling*tinnitus ringing in the ears*tongue disorder (AU: What is meant by tongue disorder?)tongue edema swollen tongue* tongue papillar hypertrophy big tongue*tongue swelling swollen tongue*tongue thickness tongue thickness * tongue ulceration mouth blisters/sores* tooth discoloration tooth discoloration*tooth fracture broken toothtorsade de pointes irregular heartbeat torticollis bent neck*

Tourette's syndromeTourette's syndrome (uncontrolled speech and/or muscle movements)



toxic anterior segment syndrome (TASS)


toxic epidermal necrolysis

very severe blistering skin disease (loss of large portion of skin) (Editor: if the drug also causes Stevens Johnson, combine as "very severe blistering skin disease (loss of large portion of skin and/or ulcers of the skin and digestive tract)")

toxic megacolon enlarged bowel (possible abdominal pain)

toxic nephropathydecreased kidney function (possible kidney failure)

toxic psychoses psychosis (loss of contact with reality) toxic psychosis psychosis (loss of contact with reality)

toxic pustuloderma


toxic skin reactions severe skin reaction

toxicoderma(AU: What does toxicoderma specifically cause?)

toxoplasmosis


tracheobronchial calcification calcium deposits in the airways



tracheoesophageal fistulaabnormal hole between the trachea and esophagus

transaminases increased


transfusion reaction

reaction to a blood transfusion (Editor: If this is Amphotericin B change this to infusion reaction (possible chills and/or hives). If not, AU: What is specifically meant by transfusion reaction?)

transfusion-associated GVHD

graft-versus-host disease (when transplanted donor tissue attacks the tissues of the recipient's body) if you have a blood transfusion

transient alteration of force of heart muscle decreased heart functiontransient ischemic attack temporary stroke symptomstransient ischemic event temporary stroke symptomstransient pain pain*transient reduction in oxygen saturation as (Editor: Delete this no matter what.)

transverse myelitis

spinal cord inflammation (possible pain, weakness, loss of feeling or movement, and/or paralysis)

tremor tremors*tremors tremors*

trigger finger swelling of the tendons that bend the fingers*

triglycerides increasedhigh blood levels of fat (possible heart disease and/or stroke)

trismus lockjaw

troponin increase abnormal blood test (possible heart problems)

TTPmultiple blood clots (possible organ dysfunction and/or failure)

tuberculosis




tubular necrosis death of kidney tissue (possible kidney failure)

tumor cell lysis

breakdown products of the cancer cells entering the blood stream (possible weakness, low blood pressure, muscle cramps, kidney damage, and/or other organ damage)

tumor flare

(Editor: For Goserelin, Anastrozole, and Leuprolide Acetate it is "pain and/or inflammation at tumor site".) (AU: Does the "tumor flare" mean "tumor growth" or "pain and/or inflammation at tumor site"?)

tumor hemorrhage bleeding in or from the tumor

tumor lysis syndrome

breakdown products of the cancer cells entering the blood stream (possible weakness, low blood pressure, muscle cramps, kidney damage, and/or other organ damage)

tumor necrosis

(AU: What does tumor necrosis cause? Editor: For Imatinib and Sunitinib, Ask: Is the tumor necrosis TLS?)

tumor pain pain at thetumor siteT-wave inversion irregular heartbeat twitching uncontrolled movements *tympanic membrane perforation painful torn eardrum

ulcersores (Editor: Delete if there is another sore/ulcer.)

ulcerationsores (Editor: Delete if there is another sore/ulcer.)

ulcerative colitisinflammation of the colon (possible abdominal pain and/or diarrhea)

ulcerative esophagitis esophageal sore*ulcerative keratitis eye ulcerulcerative stomatitis mouth blisters/sores* unpleasant taste abnormal taste*unsteady gait difficulty walking upper gastrointestinal ulcer stomach ulcer

upper GI inflammatory disorders

(AU: What specifically is meant by "upper GI inflammatory disorders"? Editor: For Capecitabine, take this AE out.)



upper respiratory infection

The drug may cause an increased risk of infection, such as pneumonia. This infection may occur anywhere. (AU: Does this agent cause a site-specfic infection that should be included?) It may become life-threatening. Symptoms of infection may include fever, pain, redness, and difficulty breathing. (EDITOR: Take this out if low white blood cell counts is already included.)

upper respiratory tract disorders

disorders of the upper airways* (AU: What is specifically meant by upper respiratory tract disorders?)

upper respiratory tract infection


urea increased


uremiawaste products in the blood (Editor: Remove if kidney failure is already present.)

ureteral outlet obstructionurinary system blockage (possible difficult and/or painful urination)

ureteral stricture

narrowing of the tube that carries urine* (AU: Can ureteral stricture be caused by the study drug? Editors: For Bevacizumab, take this AE out.)

ureteric obstructionblockage in the tubes that drain urine from the kidneys

ureteritis inflammation of the tubes that carry urine

ureteropelvic junction obstructionblockage in the tubes that drain urine from the kidneys

urethral hemorrhage blood in the urine

urethral obstructionurinary system blockage (possible difficult and/or painful urination)

urge incontinence loss of bladder control*


Medical Term Lay Lanuguageurgency urge to urinate*

URI


uric acid increasedhigh blood levels of uric acid (possible painful joints and/or kidney failure)

urinary debris debris in the urine*

urinary disorder

urinary disorder (AU: What is specifically meant by urinary disorder? Editor: For Leuprolide Acetate, take this AE out.)

urinary fibrosis urinary tract scarringurinary frequency frequent urination*urinary impairment difficulty urinating urinary incontinence loss of bladder control *

urinary obstructionurinary system blockage (possible difficult and/or painful urination)

urinary precipitationbuild-up of drug in the urine (possible painful urination, kidney stone, and/or kidney pain)

urinary retention inability to urinate

urinary tract disorder




urinary tract infection


urinary tract spasmurinary tract spasm (possible pain/urge to urinate/difficulty urinating)

urinary urgency urge to urinate*urination impaired difficulty urinating urine discoloration (blue-green) blue-green urine color*

urine specific gravity decreasedabnormal urine* (AU: Take out if we have the general mineral, salt statement.)

urine specific gravity increasedabnormal urine* (AU: Take out if we have the general mineral, salt statement.)

urolithiasis kidney stones*

urosepsis


urticaria hives*urticaria vesiculosa hives* uterine bleeding uterine and/or vaginal bleedinguterine polyps abnormal growth in the uterus

UTI




UTI


uveitisinflammation inside the eye (possible vision problems)

vaginal bleeding uterine and/or vaginal bleeding

vaginal candidiasis


vaginal dryness vaginal dryness*vaginal hemorrhage uterine and/or vaginal bleedingvaginal irritation vaginal irritation*

vaginal moniliasis


vaginal stenosis

narrowing of the vagina* (AU: Is vaginal stenosis related to the drug? Editor: Leave this in if a radiation study.)

vaginitis vaginal inflammation*

valvular heart diseaseheart disease caused by heart valves not working

variable decrease in factors VII and IX increased risk of bleeding



vascular access hemorrhage

catheter site bleeding (AU: Is vascular access hemorrhage due to low platelets or something specific?)

vascular access infection


vascular access thrombosisblood clotting at the catheter site (Editor: Delete if increased risk of clotting is listed.)

vascular disorderblood vessel disorder (AU: What does vascular disorder specifically cause?)

vascular leak syndrome blood leaking from vessels into tissuevascular occlusive events severe heart problems

vascular pseudoaneurysm

leaking of blood from an artery to the surrounding tissue (usually as a result of a puncture to the artery)

vascular thrombosisblood clots in a vein (possible pain, swelling, and/or redness)

vascular thrombotic diseaseblood clots in a vein (possible pain, swelling, and/or redness)

vasculitisblood vessel inflammation (possible bleeding and/or bruising)

vasculitis with rashblood vessel inflammation (possible bleeding, bruising, and/or rash)

vasoconstriction narrowing of blood vessels (possible change in blood pressure)

vasodilation flushing*vasodilation flushing*

vasospasmblood vessel spasm (possible blockage of blood flow)

vasovagal episodelow blood pressure (possible dizziness/fainting)

vasovagal reactionlow blood pressure (possible dizziness/fainting)

vein pigmentation darkened vein color* veno-occlusive disease liver damage due to blood clotsveno-occlusive hepatic disease liver damage due to blood clotsveno-occlusive liver disease liver damage due to blood clots



venous pressure increased

increased pressure in the veins (AU: Is venous pressure increased caused by the drug, if not what is causing this?)

venous thromboembolic eventsblood clot in a vein (possible pain, swelling, and/or redness)

venous thrombosisblood clots in a vein (possible pain, swelling, and/or redness)

venous thrombotic eventsblood clots in a vein (possible pain, swelling, and/or redness)

ventricular arrhythmia irregular heartbeatventricular dysfunction severe heart problems ventricular extrasystoles irregular heartbeat ventricular failure heart failureventricular fibrillation sudden stopping of the heart ventricular hypertrophy enlarged heartventricular tachycardia fast heartbeatvertebral compression fractures collapse of bones in the spinevertigo dizziness vesicles blistersvesicular rash blistering skin rashvesiculation blistersvesiculobullous dermatitis severe blisters vesiculobullous rash blistering skin rash

vestibular damageinner ear damage (possible dizziness and/or problems with balance)

virilismdevelopment of male features in females (such as increased body hair)*

visceral arterial ischemia decrease in blood flow to internal body organsvision abnormal vision problems*vision blurred blurry visionvision disturbance vision problems* vision loss blindnessvisual accommodation disturbance vision problems* visual acuity change blurry visionvisual acuity decreased blurry visionvisual brightness bright spots in the vision*visual changes vision problems*visual disturbances vision problems*visual field abnormality blind spotsvisual field deficit blind spotsvital capacity lung damage (possible difficulty breathing)

vitamin B12 deficiency

low blood level of vitamin B (possible anemia, spinal cord damage, and/or mental status change)


Medical Term Lay Lanuguagevitiligo patches of skin color loss*vitreous floaters spots in the vision*

vitreous hemorrhage

bleeding in the eye (AU: Is vitreous hemorrhage due to low platelet counts or a direct effect of the drug?)

vivid dreams vivid dreams*voice alteration voice changes*volume overload heart failure vomiting vomiting*

vulvovaginitisinflammation of the female genitals and vagina*

warmth sensation feeling of warmth*water retention swelling*

WBC abnormality


WBC decreased


weakness weakness*weeping/exudate oozing from a wound*

Wegener's granulomatosinflammation of blood vessels in the lungs, kidneys, and/or other organs

weight gain weight gain* weight loss weight loss*wheezing wheezing*

white blood cell count increased

increase in infection-fighting cells* (AU: Is increased white blood cell count directly linked to the drug?)


Medical Term Lay Lanuguagewidened QRS complex abnormal EKG*

withdrawal syndrome

Suddenly stopping (study drug) may cause withdrawal symptoms. (AU: What are the withdrawal symptoms of this drug?)

worsening gallstones worsening of existing gallstoneswound dehiscence opening of a wound wound healing complications wound healing problemswound healing impaired wound healing problemswound healing impaired wound healing problemswrist drop nerve damage (wrist weakness)writing impaired difficulty writing* xanthopsia vision problems* xeroderma dry skin*xerophthalmia dry eyes*xerostomia dry mouth*zoster shingles (painful skin rash)

hyperparathyroidism

high hormone blood levels resulting in high calcium blood levels (possible bone pain, nausea, and/or kidney stones)

increased TSHunderactive thyroid gland (possible weight gain, heart failure, and/or constipation)

thyroid stimulating hormone increased underactive thyroid gland (possible weight gain, heart failure, and/or constipation)

TSH increased underactive thyroid gland (possible weight gain, heart failure, and/or constipation)

pneumomediastinumair in the chest between the lungs and chest wall

decreased appetite loss of appetite* abnormal cranial sensation abnormal sensation on the scalp*

increased serum creatinineabnormal kidney test (possible kidney damage)*

increased serum amylase

abnormal blood test (possible pancreas damage)* (Editor: Take out if pancreas damage listed elsewhere.)

increased serum lipaseabnormal digestive blood test (possible inflammation of the pancreas)*

hemophagocytic lymphohistiocytosis immune system reaction (possible fever, jaundice, liver/spleen enlargement, irritability, and/or seizures)

HLH

immune system reaction (possible fever, jaundice, liver/spleen enlargement, irritability, and/or seizures)



hematologic disease (impaired stem cell mo

[Drug] may cause problems with collecting your own stem cells which may cause you to be unable to receive certain types of stem cell transplants.

Sjogren's syndrome

immune system disease (possible dry mouth/eyes, fatigue, joint pain, and/or organ failure)

type 1 diabetes diabetes requiring insulintype I diabetes diabetes requiring insulin

Sjogren syndrome

immune system disease (possible dry mouth/eyes, fatigue, joint pain, and/or organ failure)

Vogt Koyanagi Harada syndrome

pigmented tissue (possible eye pain/swelling, hearing loss, and/or loss of skin color)

side effect glossary - mdanderson.org

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