sildenafil presentation, by emmanuel michael : sjut tapsa
TRANSCRIPT
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EMMANUELEMMANUEL MICHAEL
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1.INTRODUCTION
Sildenafil citrate sold as Viagra,Revatio and under various other trade nameIs a drug used to treat erectile dysfuction and pulmonary arterial hypertension.
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STRUCTURE
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Mechanism of Action
It acts by inhibiting Cgmp specific phosphodiasterase type 5 PDE5 an enzyme that promotes degradation of c GMP which regulate blood in the penis.
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OTHER DRUGS WITH SIMILAR MECHANISM OF ACTION
•Tadalafil-Cialis•Vardenafil-Levitra
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INDICATION•The primary indication of sildenafil is treatment of erectile dysfuction(inability to sustain satisfactory erection to complete intercourse)•Its use is now standard treatment for erectile dysfuction in all setting
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Indication continued……………………•As well as erectile dysfuction sildenafil citrate is also effective in Pulmonary Arterial Hypertension(PAH)•It relaxes the arterial wall,leading to decreased pulmonary arterial resistance and pressure.
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DOSAGE
Viagra pills are available in 25mg,50mg and 100mg from
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ADVERSE EFFECTS•Dyspepsia•Nausea•Headache•Visual disturbance•Back pain•Dizziness•Less common are tinnitus,dry mouth,drowsiness,vertigo and fatigue
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INTERACTION
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• Protease inhibitors for treatment of HIV• Its recommended that patients using
protease inhibitor limit their use of sildenafil to more than one 25mg every 48 hours
• Alpha blockers-concomitant use lead to low blood pressure.
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CONTRAINDICATION
•When taking nitric oxide donors,organic nitrites,and nitrates such as nitroglycerin,sodium nitroprusside and amy nitrite•Severe hepatic impairment•Severe impairment in renal function•Cardiovascular problem•Recent stroke or heart attack