Symbotex™ Composite Mesh for ventral hernia repair

SIMPLY SMART

Smart designInnovative mesh streamlines performance

∙ Exclusive 3-D mesh structure delivering reinforced textile strength1 and significanttissueingrowthsupport2

∙Mesh transparency for improved anatomy visualization during placement3

∙Establishedcollagenbioabsorbablefilmtechnologywithimpressiveresistanceto surgical handling4,5

∙Comprehensive shape and size portfolio for small, medium, and large defects4,6

Smart handlingExperience simplicity in hernia repair

∙ Designed for easy mesh deployment3

∙ Centering and orientation marking for accurate mesh positioning3,4,†

∙Abdominalwallclingingeffectforsimplifiedmesh placement3,7,‡

Smart repairDesignedtoofferyour patients optimized hernia repair performance

∙ Excellent tissue integration8

∙ Minimized visceral attachment9

∙ Good level of neoperitonization and better minimizing tissue attachment comparedwithBardDavolVentralight™* ST mesh10,§

∙ Helping to meet patients’ physiological needs through balanced mesh mechanical properties1,11,12

† If the mesh is not cut (refer to Instructions for Use). ‡ Exceptincaseswheretransfascialsuturesareusedaswellasmeshesinopenapproach.§ Fourweeksafterimplantation.

Symbotex™ composite mesh for ventral hernia repair

Exclusive 3-D mesh structure1

Stronger fixation with ReliaTack™ Articulating Reloadable Fixation Device 14,†

Histologicalpictureofmeshimplantationatfourweeksinananimalmodel15

∙Oneweekafterimplantation,mesothelialcellscolonizedthesurfaceofthebioabsorbablefilm,whichisintactandcontinuous.Ontheparietalside,severaltypesofcellscolonizedthe3-Dstructureofthetextile,includingfibroblasts,whichparticipateinthesynthesisoftheneo-collagen.

∙Twoweeksafterimplantation,mesothelialcellsbegintodegradethebioabsorbablefilm.Ontheparietalside,thetextilestartstobeintegratedintotheabdominalwall,whilekeepingits3-Dstructure and porosity.

∙Fourweeksafterimplantation,themeshisintegratedintotheabdominalwall.Noinflammatoryreaction is observed.

3-D monofilamenttextile

Large pore

Histologicalsectioninaratatfourweeks

3-Dmonofilament macroporous textile Pore size13: 2.1 mm x 3.0 mm Density13: 64 g/m² Thickness13: 0.7 mm

Bioabsorbablecollagenfilm4,5

Orientation marking

†Benchtoptestingbasedoncommerciallyavailableabsorbableandpermanentfixationdevices,whichincludetheSECURESTRAP™*, SorbaFix™*,OptiFix™*, CapSure™*, ProTack™,andReliaTack™deviceswithstandardpurchasetackswhentheshaftisangledat30,45,65,and90degrees.ReliaTack™devicedeeppurchasetackshearpulltestperformedinsyntheticfoam.Resultsmaynotcorrelatetoperformanceinanimal or cadaveric tissue, or performance in humans.

Contact your Medtronic sales representative and learn more at medtronic.com/symbotex

IMPORTANT: Please refer to the package insert for complete instructions, contraindications, warnings and precautions.

References

1. Basedoninternalbenchtoptestreport#TEX044.October2014.2. CobbW,LomantoD,LecuivreJ,etal;HerniaCenter,GreenvilleHospitalSystemUniversityMedicalCenter.Comparativeanalysisoftheperformanceofaseriesofmeshesbasedonweightandporesizein

a novel minipig hernia model. Hernia. 2013;17(suppl1):S54.3. Basedoninternaltestreport#0901CR252a,PreclinicalstudyonpigsbysurgeonsfordesignvalidationofSymbotex™. June 2013. 4. Basedoninternaldesignvalidationreport#0901CR249a,ResultsofaninternallysponsoredpreclinicalstudycarriedoutonaporcinemodeltovalidatethedesignofSymbotex™ composite mesh. June 2013. 5. Basedoninternaldesignverificationreport#0901CR247b.July2013.6. Basedoninternalsizeandshapecomparisonchart.7. Basedoninternaltestreport#0901CR261a,ObservedclingingeffectofSymbotex™ during design validation. July 2013. 8. BasedonNAMSAreport#162750,usingaporcinemodeltoevaluatelocaltissueeffectsandtissueintegrationofSymbotex™ composite mesh vs. Parietex™

optimized composite mesh after laparoscopic ventral repair. May 2013. 9. BasedonNAMSAreport#162750,Localtissueeffects,tissueintegrationandminimizingtissueattachmentperformanceofSymbotex™ composite mesh in a rat caecal abrasion model. May 2013. 10. BasedonNAMSAreport#163905,Symbotex™compositemeshvs.competitorsinapigbowelabrasionmodel.October2013.11. LepereM,ZaranisC,KhalilH,etal.Twoyearresultsofincisionalandprimaryventralherniarepairwithanovelthree-dimensionaltextilecompositemesh:TheSymCHroregistrystudy.Abstractpresentedin

IHC Congress 2018.12. Köckerlingetal.2017-TheImportanceofRegistriesinthePostmarketingSurveillanceofSurgicalMeshes.Annals of Surgery, 2017. doi: 10.1097/SLA.0000000000002326 13. Basedoninternaltestreport#TEX001.February2017.14. Basedoninternaltestreport#RE00010135-1,ReliaTack™devicedeeppurchasetackshearpulltestperformedinsyntheticfoam.Resultsmaynotcorrelatetoperformanceinanimalorcadaverictissue,

or performance in humans. p-value=0.00. October 2015.15. BasedonNAMSAstudy#163905andhistologicalobservationsreport#0901CR263a.May2013.

Laparoscopic ventral repair (all sizes indicated in cm)

Open ventral repair

40 x 24 SYM4024E

34 x 20 SYM3420E

25 x 15 SYM2515E

20 x 12 SYM2012E

17 x 10 SYM1710E

30 x 20 SYM3020

37 x 28 SYM3728

42 x 32 SYM4232

25 x 20 SYM2520

20 x 15 SYM2015

15 x 10 SYM1510

8SYM8OS

15 x 10 SYM1510OS

20 x 15 SYM2015OS

25 x 20 SYM2520OS

30 x 20 SYM3020OS

9 diameter SYM9

12 diameter SYM12

15 diameter SYM15

20 diameter SYM20

© 2019 Medtronic. All rights reserved. Medtronic, Medtronic logo and Further, Together are trademarks of Medtronic. ™* Third party brands are trademarks of their respective owners. All other brands are trademarks of a Medtronic company. 03/2019–P140003(2)–[WF# 880583]

medtronic.com/covidien555 Long Wharf DriveNew Haven, CT 06511 800.722.8772

HERNIACARE Mesh. Fixation. Permacol™. Dissection.

Our comprehensive product portfolio can enhance your hernia repair procedures.