software for wearables can measure brain health

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PRESS RELEASE 12 August 2016 © Cognition Kit 2016. All rights reserved. www.cognitionkit.com Software for wearables can measure brain health Mental health conditions are now the leading causes of disability worldwide. With more than 450 million people living with mental illnesses the costs of treatment and care to global economies is predicted to double by 2030 to over $6 trillion (World Health Organization). A team of scientists and software designers in the UK has developed new wearable software to aid early intervention and monitoring of conditions affecting the brain. Neurological conditions are commonly characterised by day-to-day variability in symptoms like mood, anxiety, and problems with concentration and memory. This fluctuation impacts the daily lives of those living with the conditions, for example making it more difficult to make advance plans, perform consistently at school or in work, or maintain steady relationships. Standard infrequent clinical tests by doctors or researchers cannot detect this variability in symptoms, so it is often ignored, missed, or leads to an inaccurate diagnosis. Cognition Kit is a wearable software platform that will enable doctors, scientists and the public to better understand and manage day-to- day brain health by accurately measuring biological and psychological factors affecting cognitive performance more frequently. Cognition Kit micro test shown on a Microsoft Band 2 designed to measure memory and attention The results of the study, presented at the Alzheimer's Association International Conference, found that for the first time wearable consumer devices could be used to accurately measure cognition and brain health using Cognition Kit. The technology could now help improve the development of disease-modifying treatments, treat mental health conditions at the earliest opportunity and objectively measure patient outcomes as a means of reducing the health and economic burden of mental illness. During the study participants wore a wearable device to monitor their levels of stress and physiological activation using built-in sensors of heart rate, galvanic skin response and skin temperature. The study used the Microsoft Band 2, a fitness tracker with smartwatch features, selected for its extensive sensors. Cognition Kit however is being developed to be compatible with use on all major wearable brands. Throughout each day of the study, subjects were prompted to complete quick micro tests of cognition on the Band. These game-like tests measured attention, memory and reaction speed at different times of day. Over 30 million data points were recorded during the two week study, which has shown distinct patterns of performance within and across days, allowing a rich picture of subjects’ cognitive function to emerge. This has the potential to provide a powerful tool for researchers, complementing traditional infrequent and in-depth testing.

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Page 1: Software for wearables can measure brain health

PRESS RELEASE 12 August 2016

©CognitionKit2016.Allrightsreserved. www.cognitionkit.com

SoftwareforwearablescanmeasurebrainhealthMental health conditions are now the leading causes of disability worldwide.Withmore than 450million people living withmentalillnesses the costs of treatment and care to global economies is predicted to double by 2030 to over $6 trillion (World HealthOrganization).AteamofscientistsandsoftwaredesignersintheUKhasdevelopednewwearablesoftwaretoaidearlyinterventionandmonitoringofconditionsaffectingthebrain.Neurological conditions are commonly characterised by day-to-day variability in symptoms like mood, anxiety, and problems withconcentration and memory. This fluctuation impacts the daily lives of those living with the conditions, for example making it moredifficulttomakeadvanceplans,performconsistentlyatschoolorinwork,ormaintainsteadyrelationships.Standardinfrequentclinicaltests by doctors or researchers cannot detect this variability in symptoms, so it is often ignored, missed, or leads to an inaccuratediagnosis.CognitionKitisawearablesoftwareplatformthatwillenabledoctors,scientistsandthepublictobetterunderstandandmanageday-to-daybrainhealthbyaccuratelymeasuringbiologicalandpsychologicalfactorsaffectingcognitiveperformancemorefrequently.

CognitionKitmicrotestshownonaMicrosoftBand2designedtomeasurememoryandattentionThe results of the study, presented at the Alzheimer's Association International Conference, found that for the first time wearableconsumerdevicescouldbeusedtoaccuratelymeasurecognitionandbrainhealthusingCognitionKit.Thetechnologycouldnowhelpimprovethedevelopmentofdisease-modifyingtreatments,treatmentalhealthconditionsattheearliestopportunityandobjectivelymeasurepatientoutcomesasameansofreducingthehealthandeconomicburdenofmentalillness.Duringthestudyparticipantsworeawearabledevicetomonitortheirlevelsofstressandphysiologicalactivationusingbuilt-insensorsofheartrate,galvanicskinresponseandskintemperature.ThestudyusedtheMicrosoftBand2,afitnesstrackerwithsmartwatchfeatures,selectedforitsextensivesensors.CognitionKithoweverisbeingdevelopedtobecompatiblewithuseonallmajorwearablebrands.Throughouteachdayofthestudy,subjectswerepromptedtocompletequickmicrotestsofcognitionontheBand.Thesegame-liketestsmeasuredattention,memoryandreactionspeedatdifferenttimesofday.Over30milliondatapointswere recordedduring the twoweek study,whichhas showndistinctpatternsofperformancewithinandacross days, allowing a rich picture of subjects’ cognitive function to emerge. This has the potential to provide a powerful tool forresearchers,complementingtraditionalinfrequentandin-depthtesting.

Page 2: Software for wearables can measure brain health

PRESS RELEASE 12 August 2016

©CognitionKit2016.Allrightsreserved. www.cognitionkit.com

SampledatafromthestudyshowsdailyvarianceincognitiveperformancebetweentwosubjectsAftereachcognitivegame,subjectsreportedhowtheyfeltbyselectingoneofsixfacestoconveytheircurrentmood.OnJune24th,thedayoftheEUreferendumresultsintheUK,theresearchersevenobservedasignificantdropinthegeneralmoodoftheBritishparticipantsinthestudy.

Cognition Kit are now seeking commercial partners and expect to sign firstcontracts in the coming months following significant interest frompharmaceutical companies and healthcare providers wanting to reliablydemonstratetheoutcomesoftreatmentsanddetectearly indicatorsofmentalhealthconditionsbeforefurtherdamageisdone.Francesca Cormack, PhD, Director of Research and Innovation, CambridgeCognitioncommented:”Thisproofof concept studydemonstrates that for the first time, theseconsumerdevicesaremakingpossible the rapidcollectionoflargescalescientificdatasets.Thisnotonlyallowsdramaticallymoredetailedknowledgeofmoment-by-momentbrainfunction,butalsoopensupnewpossibilitiestodevelopmachinelearningalgorithmsthatwillallowearlierdetectionandinterventioninbraindisorders.”BenFehnert,Co-founderofCtrlGroupandDirectorofCognitionKitcommented:”Simple,regularinteractionwithpeoplesownphonesandwearabledevicesiskeytohelpingunderstanddailyandlongertermfluctuationsincognitivefunction.ThisstudyisthefirstdemonstrationofhowCognitionKitsoftwarecanbuildarichpictureofbrainhealthusingpeoplesowndevicesduringtheirdailylives.”

Page 3: Software for wearables can measure brain health

PRESS RELEASE 12 August 2016

©CognitionKit2016.Allrightsreserved. www.cognitionkit.com

Notestoeditors

AboutCognitionKitCognitionKitisajointventurebetweenCambridgeCognitionandCtrlGroupformedin2016todevelopdigitalhealthtoolsonmobileandwearabledevices.CognitionKitsoftwaretakesresearchoutofthe laband intodaily life,enablingdoctors,scientistsandthepublictobetterunderstandandmanageday-to-daybrainhealth.www.cognitionkit.com @cognitionkit [email protected] Cognition is a neuroscience digital health company specialising in the precise measurement of clinical outcomes inneurologicaldisorders.TheCompanydevelopsandmarketsvalidatednearpatientassessmentproductsusingcognitionasabiomarkertoimprovetheunderstanding,diagnosisandtreatmentofmentalhealthdisordersworldwide.Partners include the world’s leading biotechnology and pharmaceutical companies, academic institutions and public-private healthorganisations.www.cambridgecognition.com @CANTABconnect press@camcog.comAboutCtrlGroupCtrlGroupbelievethatnewtechnologieshavethepotentialtotransformhealthcareandmedicalresearchbyincreasingefficiencyandcreatingmorepersonalisedmedicine.Weareateamofdesigners,researchers,softwaredevelopersandhealthcareexpertswhoworkinternationallywithhealthcarecompaniesandproviderswhowanttousenewtechnologytoimprovepeople’shealth.www.ctrl-group.com @ctrl_group [email protected]