8/12/2019 Some Causes of Peripheral Nervous System Disorders

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Muscle fiber Dystrophies Distal muscular dystrophy (late distal hereditary

myopathy; rare), Duchenne muscular dystrophy and

related dystrophies, fascioscapulohumeral muscular

dystrophy, limb-girdle muscular dystrophy,

oculopharyngeal dystrophy (rare)

Channelopathies

(myotonic)

Familial periodic paralysis, myotonia congenita

(Thomsen disease), myotonic dystrophy (Steinert

disease)

Congenital Central core disease, centronuclear myopathy,

nemaline myopathy (very rare)

Endocrine Acromegaly, Cushing syndrome, diabetes mellitus,

hypothyroidism, thyrotoxic myopathy

Inflammatory Infection (viral more than bacterial), polymyositis and

dermatomyositis

Metabolic Acid maltase deficiency, alcoholism, carni tine

deficiency, glycogen storage and lipid storage

diseases (rare), hypokalemia

*Upper motor neuron disorders (eg, spinal muscular atrophies) technically involve the CNS because

the cell body of the motor neuron (anterior horn cell) is located in the spinal cord.

Adapted from Tandan R, Bradley WA: Amyotrophic lateral sclerosis. Part I: Clinical features, pathology

and ethical issues in management.Annals of Neurology18:271280, 1985; used with permission of

Little, Brown and Company.

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