source of drugs
DESCRIPTION
Vijayfarmac source of drugsTRANSCRIPT
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:Pharmacology:
It is a science of drugs. It covers all aspects of knowledge of drugs.
Drug: Any substance or product that is used or intended, to be modify or explore physiological systems or pathological states for the benefit of the recipient. (Wld.Hlth.Org.Tech)
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Drug Nomenclature
• Every drug has three of names.
1.Chemical Name
2.Nonproprietary Name (Generic Name)
3.Proprietary name (Trade/Brand Name)
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Chemical name: These are given according to the chemical constitution of drug
• Chemical– Gives exact chemical composition of the drug – Places atoms or molecular structure
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Nonproprietary name: (Official Name) It is assigned by the United States Adopted Name (USAN) council. It is uniform all over world.
Generic Name:
-Typically derived from chemical name– Usually shorter
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Proprietary name: It is given by the pharmaceutical manufacture.
• Trade Name– Name registered by the manufacturer– trademark symbol®– only be used by the single manufacturer– Same drug May have several trade names
(depending on number of manufacturers)– The first letter of the name is Capitalized
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Chemical Name Non proprietary Trade Name
Acetyl ASPIRIN Disprin (India)
Salicyclic acid Bayer’s Asprin (USA)
Ecospirin (India)
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Source of Drugs
• Natural
•Plants•Animal• Micro organisms
•Mineral
• Synthetic
• Semi synthetic • Synthetic
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Source Plant Drug Use
Leaf Digitalis Digoxin CHF
Bark Cinchona Quinine Malaria
Fruit Opium Morphine Analgesic
Seed Eserin Anticholinestrase M.G
Contd.,
PLANT SOURCE
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PLANT SOURCE
• PlantsExample Trade Name
ClassificationChinchona BarkQuinidine Antiarrhythmic,
Malaria
Purple Foxglove Digitalis Cardiotonic
Poppy Plant Paregoric,Antidiarrheal,
(Opium) Morphine, Analgesic,Codeine Analgesic,
Antitussive
Contd.,
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• Nicotiana tabacum• Nicotinic receptor
stimulant
Atropa belladonnaAnti cholinergic drug used in OP Poision
Opium seed Morphine Analgesic
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Morphine preparation
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Vinca rosea Vinka alkaloids Anti cancer
Digitalis purpurea (foxglowe) Digitalis CHF
Cinchona pubescens Quinine Malaria
Rauwolfia serpentina (INDIA) Reserpidine Antihypertesive agent
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Important Pharmacological active principles in plants are:
1)Alkaloids
2)Glycosides
3)Oils
4)Resins
5)Gums
6)Tannins
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1.ALKALOIDS
• Nitrogenous hetrocyclic bases.• Insoluble in water.• Form salts with acids, which are soluble in
water.
Ex: Drug Plant Atropine Atropa belladonaQuinine Cinchona bark
Contd.,
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Drug Plant
• Morphine Papavaram somniferum(Poppy)• Reserpine Rauwolfia serpentina• Nicotine Tobaco leaves
• Alkaloids names usually end with “ine”.
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2.Glycosides
• These are combinations of sugar with other organic structures.
O Glycoside
Sugar portion governors the pharmacokinetic characteristic of glycoside.
Contd.,
Glucose Non sugar
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• On hydrolysis with mineral acids all glycoside split up into sugar and non sugar residues.
Ex: Cardiac glycosides Digitoxin, Digoxin are obtained from Fox glove leaves (Digitalis purpurea).
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3.OILS
• Generally 3 types of oils are used for medical purposes.
i) Essential oils (Volatile oils)ii) Fixed oils.iii) Mineral oils
Contd.,
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i) Essential oils (Volatile oils)
• Obtained from leaves or flower petals by steam distillation.
• Terpene derivative so these have aroma • Steam volatile • No food value (caloric)• Do not from soaps with alkaloids• They do not rancid (Foul smell) on prolong
stay
Contd.,
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Uses:- • Carminatives:- For expulsion of gas from
stomach. Ex:-Ginger, eucalyptus oil. (act as irritant to gastric mucosa)
• Antiseptic:- Mouth washes.
• Flavouring agents:- Peppermint oil
• Pain relieving agents:- Clove oil for toothacheActs as counter irritant
Contd.,
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ii) Fixed oils
• Obtained by solvent extraction of crushed seeds.
• Triglycerides. • Saturated from Animal • Unsaturated from Plant • Non volatile• Have caloric value• Form soaps with alkaloids• Become rancid on prolong stay
Contd.,
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• Ex: Ground nut oil Coconut oil Olive oil
Uses: • Castor oil as a purgative
Contd.,
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iii) Mineral oils
• Obtained by dry distillation of wood.
Ex:- Liquid paraffin (hydrocarbon derived from petroleum)
Uses:-Lubricant laxative for promote defecation.
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4) Resins
• These are polymers of volatile oils and insoluble in water.
• Ex: Benzoin
Use:• Used as inhalational in common cold• Treatment in cough
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5) Gums
• Secretary products of plants • These are dispersible in water and form
adhesive mucilaginous colloids
Ex:- Gum acacia
Uses:-
Emulsifying or suspending agents.
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6) Tannins
• Non nitrogenous phenolic derivatives from plant.
• Soluble in water.
• Ex:- Astringents (precipitate surface proteins)
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ANIMAL SOURCE
• Obtained from animal Drug AnimalHeparin LeechInsulin Pork pancreasThyroxin Thyroid Vit. B12 Liver extractCod liver oilAnti toxic sera
Contd.,
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• AnimalsExample Trade Name
ClassificationPancreas of Cow, Insulin; regular, AntidiabeticPancreas of pork Hormone
Stomach of Cow, Pepsin Digestive Hormone
Thyroid Gland Thyroid, USP HormoneOf Animals
ANIMAL SOURCE
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MICROORGANISM SOURCE
• Bacterial, Fungi, Moulds imp source of many life saving drugs.
• These obtained from MO and used to kill Microorganisms.
Drug Microorganism• Penicillin Penicilium notatum• Chloramphenicol Streptomyces
venezuelace• Griseofluvin Pencillin grisofullivum• Streptomycin Streptomyces griseus• Neomycin Streptomyces fradiae
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MINERAL SOURCE
• Use in pharmacotherapy
Mineral Use• Ferrous sulfate(FeSo4)
Anaemia• Magnesium sulfate(MgSo4) Purgative • Sodium bicarbonate (NaHco3) Antacid• Aluminum Hydroxide
Antacid
Contd.,
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Mineral Sources
• MineralsExample Trade Name ClassificationMagnesium Milk of Magnesia Antacid, Laxative
Zinc Zinc Oxide Oint. Sunscreen, Skin Protectant
Gold Solganal, Auranofin Anti-inflammatory;
Used in tx of Rheumatoid
Arthritis
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SYNTHETIC• Presently majority of drugs are obtained
synthetically• Some of drugs which are earlier obtained
from plant today synthesized in lab.
Advantage • Quality can be controlled• Process is easier and cheaper• More potent and safer• Large scale production
Contd.,
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Example Trade NameClassification
Meperidine Demerol Analgesic
Diphenoxylate Lomotil Antidiarrheal
Co-Trimoxazole Septra Anti-Infective
Sulfonamide; Used in the treatment of
UTI’s
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Semi Synthetic
• These are mainly obtained by changing the chemical structure of natural obtaining drugs.
• Ex: Atropine bromide
• Penicillin substrates.( by changing –R side chain)
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Human Source
• HCG Pregnant women• Menotrophin Post Menopausal women
urine• Regular insulin Human • Urokinase Human kidney cells• rh GH Human
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GENTICALLY ENGINEERING
• Relatively new methodology involves the blending of discoveries from molecular biology, rDNA technology, DNA alteration, Gene splicing, immuno pharmacology.
Ex:-
Hepatitis-B
Insulin (Human insulin of rDNA techniques)
Contd.,
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Formation of genetically engineered Hepatitis-B Vaccine Genetic material (DNA) is first extracted from hepatitis virus
The gene that direct the production of surface protein is located
These gene is removed from viral DNA and inserted into plasmid
The plasmid are then inserted into yeast cells
Yeast is grown by fermentation.
(Cells produce large amount of surface proteins)
After 48hr, yeast cells are ruptured then extracted surface proteins
Purified and stabilized with preserving agents
HEPATITIS-B vaccine ready to use
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