Special NIH Funding Opportunities

Elizabeth Wilder, Ph.D.Director

Office of Strategic Coordination

Division of Program Coordination, Planning, and Strategic Initiatives

Office of the NIH Director

March 12, 2014

http://www.commonfund.nih.gov

27 NIH Institutes and Centers

Clinical Center

International Center

National Institute of Biomedical Imagingand Bioengineering

National Institute of Deafness and

Communications Disorders

National Institute of Diabetes and Digestive and Kidney Diseases

NIAMSNational Institute of Arthritis andMusculoskeletal and Skin Diseases

The Office of the Director (OD)

SingleCell

Analysis

Current Common Fund Programs

Enhancing the Diversity of the NIH-Funded

Workforce

PROMIS:Clinical

OutcomesAssessment

NIHCenter for

RegenerativeMedicine

RegulatoryScience

The 4D Nucleome

Human Microbiome

Protein Capture

Pioneer AwardsNew Innovator AwardsTransformative Research AwardsEarly Independence Awards Structural

Biology

Illuminating the Druggable Genome

Building Blocks,Biological Pathways

And Networks

Genotype-Tissue

Expression

Library of Integrated Network-

Based Cellular Signatures

(LINCS)

Nanomedicine

Science ofBehaviorChange

Gulf Oil SpillLong TermFollow Up

Global Health

Knockout Mouse

Phenotyping

NIH Medical ResearchScholars

Glycoscience

Big Data to Knowledge

(BD2K)

HCS ResearchCollaboratory

High-RiskResearch

NIHCommon Fund

Health Economics

Epigenomics

http://commonfund.nih.gov/

Metabolomics

Undiagnosed Diseases Program

Extracellular RNACommunication Strengthening

the Biomedical Research

Workforce

Transformative: Must have potential for exceptionally high impact — to dramatically affect biomedical and/or behavioral research over the next decade

Synergistic: Outcomes must synergize with research supported by the NIH Institues and Centers (ICs) to promote and advance individual missions of ICs and to benefit health

Cross-Cutting: Program areas must cut across missions of multiple NIH ICs. Similarly, programs must be relevant to multiple diseases or conditions

Unique: Must be something no other entity is likely or able to do, or, if similar efforts exist, the Common Fund programs must be coordinated with others. The CF supports projects that would be unlikely to be supported through traditional, investigator-initiated mechanisms.

Catalytic: Must achieve a defined set of goals within 5-10 years which will then catalyze further work supported by the ICs

FY11 Budget: $543M

Criteria for Common Fund ProgramsCommon Fund program areas are selected through a strategic planning process that identifies trans-NIH challenges or areas of exceptional opportunity that meet the following criteria:

CF Programs Build “Foundations” to Catalyze Research

■ New Tools, Infrastructure, and Data to Support or Establish New Fields of Study ■ Extracellular RNA Communication ■ Epigenomics

■ Knock-Out Mouse Phenotyping Project (KOMP2)■ Illuminating the Druggable Genome (New in FY14)

■ New Technologies and Approaches to Overcome Barriers to Progress in a Field ■ Structural Biology ■ PROMIS: Patient Report Outcomes Management System

■ Microphysiological Systems for Drug Screening

■ New Approaches to Foster Innovation and Invigorate the Research Workforce ■ High-Risk High-Reward (Pioneer, New Innovator, Transformative Research, Early Independence Awards)

■ Broadening Experiences in Scientific Training (BEST) Awards (New in FY13)■ Enhancing Diversity in the NIH-funded Workforce (New in FY13)

High-RiskHigh-Reward(HRHR) ResearchNew approaches to support exceptionally creative scientists who propose highly innovative approaches to major contemporary challenges in biomedical research

Novel approaches to peer review and funding mechanisms

TRA•Preliminary data not required• Shortened application •Transformative Research Awards allow multi-

disciplinary teams of investigators

High-Risk High-Reward (HRHR) Research Awards

TRANSFORMATIVE RESEARCH PIONEER NEW INNOVATOR

EARLY INDEPENDENCE

What? Transformative ideas that may involve large budgets

Creative scientists proposing paradigm shifting research

Early stage investigators proposing high potential impact research

Junior scientists ready for research independence

All areas of basic, clinical and translational science within the NIH mission

Budget? Up to $25 million per year for 5 years

Up to $500,000 per year for 5 years

Up to $300,000 per year for 5 years

Up to $250,000 per year for 5 years

Prelim data? Preliminary data not required

Preliminary data requirements less stringent than R01 award

Preliminary data not required

Preliminary data not required

For more information: http://commonfund.nih.gov/highrisk

Who? All career stages, applications from teams of investigators welcome

All career stages Early stage Investigators Junior investigators (within 1 year of Ph.D. or medical residency)

High-Risk High-Reward (HRHR) Research Awards

TRANSFORMATIVE RESEARCH PIONEER NEW INNOVATOR

EARLY INDEPENDENCE

What? Transformative ideas that may involve large budgets

Creative scientists proposing paradigm shifting research

Early stage investigators proposing high potential impact research

Junior scientists ready for research independence

All areas of basic, clinical and translational science within the NIH mission

Budget? Up to $25 million per year for 5 years

Up to $500,000 per year for 5 years

Up to $300,000 per year for 5 years

Up to $250,000 per year for 5 years

Prelim data? Preliminary data not required

Preliminary data requirements less stringent than R01 award

Preliminary data not required

Preliminary data not required

For more information: http://commonfund.nih.gov/highrisk

Who? All career stages, applications from teams of investigators welcome

All career stages Early stage Investigators Junior investigators (within 1 year of Ph.D. or medical residency)

We WILL have all 3competitions again next year!

Look for announcements next spring.

http://nihroadmap.nih.gov/

We WILL have all 4competitions again next year!

http://COMMONFUND.nih.gov/

CF Programs Build “Foundations” to Catalyze Research

■ New Tools, Infrastructure, and Data to Support or Establish New Fields of Study ■ Extracellular RNA Communication ■ Epigenomics

■ Knock-Out Mouse Phenotyping Project (KOMP2)■ Illuminating the Druggable Genome (New in FY14)

■ New Technologies and Approaches to Overcome Barriers to Progress in a Field ■ Structural Biology ■ PROMIS: Patient Report Outcomes Management System

■ Microphysiological Systems for Drug Screening

■ New Approaches to Foster Innovation and Invigorate the Research Workforce ■ High-Risk High-Reward (Pioneer, New Innovator, Transformative Research, Early Independence Awards)

■ Broadening Experiences in Scientific Training (BEST) Awards (New in FY13)■ Increasing Diversity in the NIH-funded Workforce (New in FY13)

Extracellular RNA Communication

Trans-NIH Involvement:-- Led by NCI and NCATS-- Working Group Members from 18 Institutes/Centers

Epigenomics: Data and Resources for the Biomedical Research Community

• Reference epigenome maps• Technology development• Discovery of novel marks• Epigenomic basis of disease• International coordination

• Data sharing• Standards

http://www.roadmapepigenomics.org/

For more information: http://commonfund.nih.gov/epigenomics/

Knockout Mouse Phenotyping Program (KOMP2)

Cohort breedingPhenotypingData UploadCohort breeding

PhenotypingData Upload

KOMP Repository

Mouse Production

ES cells

Mice/Embryos

DatabaseWeb server

Data

Data

Mouse Phenotyping Center(s)

Mice/Embryos

KOMP ES cellsEuCOMM ES cells

Mice/Embryos

MicroinjectionGermline TransmissionLacZ stainingLethality/FertilityCryopreservation

TrackingAnalysisDisplay

Cohort breedingPhenotypingData Upload

■ Partnership with International Mouse Phenotyping Consortium (IMPC)

■ Standardized, broad phenotyping of 5,000 KO mice derived from IKMC ES cells

■ Definition of in vivo function of mammalian genes and identification of new models of disease

■ Data stored in a centralized database (European Molecular Biology Lab)

KOMP2 Phenotyping Process

For more information: http://commonfund.nih.gov/KOMP2/

Nominate a gene for phenotyping athttp://www.kompphenotype.org/

Learn about the international effort at http://www.mousephenotype.org/

• IDG: Understanding the properties and functions of poorly characterized proteins from 4 protein families that are the most common drug targets

– G-Protein Coupled Receptors– Nuclear Receptors– Ion Channels– Protein Kinases

• Knowledge Management Center: What do we know, and what do we need to know about members of these protein families?

CF Programs Build “Foundations” to Catalyze Research

■ New Tools, Infrastructure, and Data to Support or Establish New Fields of Study ■ Extracellular RNA Communication ■ Epigenomics

■ Knock-Out Mouse Phenotyping Project (KOMP2)

■ New Technologies and Approaches to Overcome Barriers to Progress in a Field ■ Structural Biology ■ PROMIS: Patient Report Outcomes Management System

■ Microphysiological Systems for Drug Screening

■ New Approaches to Foster Innovation and Invigorate the Research Workforce ■ High-Risk High-Reward (Pioneer, New Innovator, Transformative Research, Early Independence Awards)

■ Broadening Experiences in Scientific Training (BEST) Awards (New in FY13)■ Increasing Diversity in the NIH-funded Workforce (New in FY13)

Regulatory Science: Improving the process for developing new therapies

Human-on-a-Chip – a collaborative initiative between NIH, DARPA, and FDA for improved toxicity and efficacy testing• Ten microphysiological systems to be represented on an integrated platform• Must replicate known responses to drugs and toxins• Must allow sustained analysis – up to 4 weeks – with multiple read-outs• Should be extendable to include mimics of pathology• NIH to encourage development of more accurate representations of

physiology and pathology• NIH will also encourage development of microsystems from iPS cells

18

For more information:

Contact information:

Today’s talk – Betsy Wilder betsywilder@nih.gov

Pioneer, TR01, New Innovators, Early Independence Award – Ravi Basavappa basavapr@od.nih.gov

Other Questions: Ellie Murcia murciae@od.nih.gov

http://commonfund.nih.gov/

Thank you!

Any Questions?