spiny stellate cells

11
1 spiny stellat e cells inhibitory interneuro ns pyramidal cells 4 3 2 3 6 7 4 6 6 3 2 2 5 1 2 0 5 5 2 6 5 0 2 1 4 0 1 4 4 1 2 7 8 0 3 8 8 7 2 ) ( 2 )) ( ) ( ) (( 2 ) ) ( ) (( 2 )) ( ) (( i i i i e e L B e e e e U L F e e e e L B e e x x x S H x x x x x x S x S C C H x x x x x x x x u C x S I C C H x x x x x x S I C C H x x x 1 2 ) ( 0 x S C F ) ( 0 x S C L ) ( 0 x S C B Extrinsic forward connectio ns Extrinsic backward connectio ns Intrinsic connectio ns Single source model Extrinsic lateral connectio ns

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inhibitory interneurons. spiny stellate cells. pyramidal cells. Extrinsic lateral connections. Extrinsic forward connections. Intrinsic connections. Extrinsic backward connections. Single source model. 0.5. 0.4. 0.3. 0. 0.2. 0.1. -0.5. 0. 0. 2. 4. 6. 8. -10. 0. 10. t. x. - PowerPoint PPT Presentation

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Page 1: spiny stellate cells

1

spiny stellate

cells

inhibitory interneurons

pyramidal cells

4 3

236

746

63

225

1205

52

650

214

014

41

278

038

87

2)(

2))()()((

2))()((

2))()((

iii

i

ee

LB

e

e

ee

ULF

e

e

ee

LB

e

e

xxxS

Hx

xx

xxxSxSCC

Hx

xx

xxx

xxuCxSICC

Hx

xx

xxxSICC

Hx

xx

1 2)( 0xSC F

)( 0xSC L

)( 0xSC B

Extrinsicforward

connections

Extrinsic backward connections

Intrinsic connections

Single source model

Extrinsic lateral connections

Page 2: spiny stellate cells

2

0 2 4 6 80

0.1

0.2

0.3

0.4

2

1

)exp(1

1)(

rxxS)exp()( e

e

ee tt

HtP

t

Impulse voltage response to synaptic input

Synaptic input as a function of voltage

-10 0 10-0.5

0

0.5

x

Page 3: spiny stellate cells

3

spiny stellate

cells

inhibitory interneurons

pyramidal cells

IntrinsicForward

BackwardLateral

Input u

FC 1,3

LC 3,2

1

32

Page 4: spiny stellate cells

4

0 0.5 1 1.5 2 2.5 3 3.5 40

0.2

0.4

0.6

0.8

1

1.2

1.4

1.6

1.8

variance = 1/2

variance = 1/16

scaling

de

nsi

ty

priors

Page 5: spiny stellate cells

5

V1 V1

RS RSIOG

input

ForwardBackward

Lateral

PPAPPASTS

FFA

V1 RS

IOG

STSFFA

PPA

Page 6: spiny stellate cells

6

V1 V1

RS RSIOG

PPAPPASTS

FFA

0 200 400

0

0 200 400-60

-40

-20

0

20

40 mode 1

0 200 400-60

-40

-20

0

20

40 mode 2

0 200 400-60

-40

-20

0

20

40 mode 3

time (ms)

inputFace (predicted)Face (observed)House (predicted)House (observed)

0.11 (100%)

5.56 (100%)

0.61 (100%)

0.55 (100%)

Page 7: spiny stellate cells

7F B FB FBL0

50

100

150

200

)|(ln imyp

A1 A1

OF OF

PC

STG

input

ForwardBackward

Lateral

4.22

PC

STG

OF

A1

A1

Page 8: spiny stellate cells

8

0 200 400-20

-10

0

10

20

30mode 1

0 200 400-20

-10

0

10

20

30mode 2

0 200 400600-20

-10

0

10

20

30mode 3

time (ms)

standard (predicted)standard (observed)oddball (predicted)oddball (observed)

A1 A1

OF OF

PC

STG

0 200 400

0

input

4.0

9 (

10

0%

)

3.5

8 (

10

0%

)

3.23 (97%)2

.74

(9

8%

)

2.1

7 (

95

%)

1.93 (100%)

Page 9: spiny stellate cells

9

-0.5 0 0.5 1 1.5 2 2.50

0.2

0.4

0.6

0.8

1

1.2

1.4

Conditional density of contrast

contrast

pro

ba

bili

ty d

en

sity

%9.99)0( Tcp

Page 10: spiny stellate cells

10

-1 -0.5 0 0.5 1-1.5

-1

-0.5

0

0.5

1

1.5

2

-1 -0.5 0 0.5 1-1

-0.5

0

0.5

1

1.5

2

log scaling

log scaling

True and inferred changes in coupling (90% confidence intervals)

Page 11: spiny stellate cells

11

Relative error variance

True and inferred changes in coupling(90% confidence intervals)

0.5 1 1.5 20

0.2

0.4

0.6

0.8

1