Proceeds to Benefit

Thursday, February 26, 2015 Embassy of Italy, Washington, D.C.

SPONSORSHIP OPPORTUNITIES

PEDIATRIC BRAIN TUMORS: HOW YOU CAN HELPNo parent should have to hear the words, “your child has a brain tumor.”

• More than 4,000 children (11 children each day) are diagnosed with a brain tumor each year.

• Brain tumors are the leading cause of cancer-related deaths in children under 10 years old.

• Brain tumors are the second leading cause of cancer-related death in all children under 20 years old.

• The average five-year survival rate for all children with a malignant brain tumor is 66%, but for more aggressive tumors (high-grade gliomas), chances of long-term survival are less than 20%.

THE NEED FOR FUNDINGFunding for pediatric brain tumor research is critical because treatments developed for adults may not be effective or appropriate for children.

• Over the past 40 years, only 4 new drugs have been developed to treat brain tumors, none of which were developed specifically for children.

• 4% of the National Cancer Institute’s budget supports pediatric cancer research and 8% of that amount supports pediatric brain tumor research.

• 1% of the American Cancer Society’s public revenues support pediatric cancer research.

• 100% of funds raised through Bella Notte will support children.

THANK YOU TO OUR 2015 BELLA NOTTE SPONSORSPremier Sponsors

• Gina and Scott Memmott

Marquee Sponsors• Joe Sestak and Susan Clark Sestak

Cocktail Sponsors• The Lilabean Foundation

VIP Sponsors• Jeffrey B. Kolodin• Mark and Shelley Micali• New America Financial• Dr. and Mrs. Roger Packer• Schlobohm Dental

Capitol Sponsors• Ms. Sally C. Curtin• Eugene Hwang and Kristina Hardy• Drs. Lindsay Kilburn and Scott Campbell• Dr. and Mrs. Nazarian• Steve Powell and Tim Atkin• Dr. and Mrs. Brian Rood• Marc and Tisha Schestopol

WHAT IS THE MISSION OF THE BELLA NOTTE EVENT?Bella Notte is a special fundraising event to support critical pediatric brain tumor research. Proceeds from the 2015 Bella Notte event will help fund a clinical trial to develop personalized therapies for pediatric high-grade glioma patients. The multi-center trial will utilize molecular profiling of the tumor to identify targeted drugs that may be more effective for the patient. This effort is part of Project Impact, the National Brain Tumor Society’s new initiative to address the barriers that are slowing drug development for pediatric brain tumors. Together, we have a real opportunity to make a difference for children with a devastating diagnosis.

EVENT DETAILSDate and Time: Thursday, February 26, 2015 6:30PM – 10:30PM

Location: Embassy of Italy, Washington, D.C.

Attire: Cocktail

Attendees: Approximately 500 guests will attend this inspirational evening featuring dining and cocktails, exciting auctions, special recognitions, and more.

SPONSOR BENEFITS � OPPORTUNITIESSponsoring Bella Notte is a chance to make a difference in the lives of children living with brain tumors.

As a sponsor, your organization will:

• Elevate your company’s visibility through our special event recognition benefits.

• Engage your employees and customers in your corporate philanthropic efforts.

• Gain exposure to regional business leaders, philanthropists, and world-class physicians.

• Partner with two leading brain tumor research institutions:

� Children’s National Health System, one of the best pediatric hospitals in America.

� National Brain Tumor Society, the largest nonprofit brain tumor organization in the nation funding pioneering research for over 20 years.

• Provide critical funds to help develop better therapies and outcomes for children on their journey to overcome brain cancer.

Visit www.braintumor.org/bellanotte to learn more or register online.

PATIENT HEROES

ISABELLA IMPAVIDO

My Full NameIsabella May Impavido

Age Now 12

Age at Treatment 6

Things I like and enjoy I enjoy playing piano, tennis, singing,

Tae Kwon Do, skiing, and cooking.When I grow up, I want to

Be a Neurosurgeon

PATIENT HEROES

MICHAEL DEMAIOMy Full Name

Michael Anthony DeMaio

Age Now 18

Age at Treatment I received a VP shunt five days after birth.

Things I like and enjoy I love music. I enjoy playing the alto saxophone, soprano saxophone and the piano. I also started playing steel drums in my college’s steel drum ensemble during my first semester at Washington College. In addition, I enjoy playing flag football, basketball and hanging out with my twin brother, Chris, and my

best friends Zach, Josh and Michael.

My Future Plans I plan on receiving my undergraduate degree from Washington College. I hope to continue my studies after graduating to obtain my master’s degree in Business Management. I would like to run my own sandwich shop one day called “HOLD DA MAYO” (a pun on my last name), get married, and start a family of my own.

ABOUT THE BRAIN TUMOR INSTITUTE AT CHILDREN’S NATIONAL HEALTH SYSTEMChildren’s National Health System has provided hope to sick children and their families–regionally, nationally, and internationally–for 140 years. Led by Roger J. Packer, MD, the Brain Tumor Institute at Children’s National seeks to care for and cure children diagnosed with brain tumors by integrating research into the clinical care mission.

Our research program is focused on:

• identifying molecular targets for alternatives to chemotherapy.

• identifying cellular targets and creating medical treatments specific to each individual child’s tumor.

• seeking to understand and mitigate the side effects of brain tumor treatments, therefore ensuring that children not only survive, but are able to thrive.

The Brain Tumor Institute evaluates one out of every ten children in the United States with a brain tumor, and many of the pediatric brain tumor therapies used around the world today were pioneered by Children’s National.

ABOUT NATIONAL BRAIN TUMOR SOCIETYAt the National Brain Tumor Society, we are fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and those who will be diagnosed tomorrow. This means effecting change in the system at all levels. Our strategic initiatives and funded programs aim to improve an understanding of brain tumors to transform research findings into new and more effective treatments as quickly as possible. To achieve these goals, we foster collaboration and change within all facets of the drug discovery and development landscape and invest wisely in key initiatives poised to deliver results.

Project Impact is our new, multi-faceted initiative to address the key interrelated barriers that are slowing drug development for pediatric brain tumors, specifically high-grade gliomas. Project Impact will combine efforts in funded research and public policy to confront inefficiencies that currently exist in both the pediatric brain tumor pre-clinical research system and pediatric cancer clinical trial environment. Together, these efforts will seek to optimize the entire pediatric brain cancer drug discovery and development pipeline and create significant advances in treatment options for children with brain tumors.

Our shared vision is to allow every child with brain cancer the chance to receive the very best possible therapy, and to survive their brain tumors without devastating long-term

side-effects from their treatments.

Presenting Sponsor: $50,000 ($48,000 tax deductible)• Opportunity to display company merchandise or distribute giveaways• 40 Sponsor tickets• Logo projected onto gallery wall at the event• Logo recognition on website and event signage*• Opportunity to host a joint event with patients and NBTS researchers at

Children’s National for 15 people

Honoree Sponsor: $25,000 ($23,500 tax deductible)• Opportunity to display company merchandise or distribute giveaways • 30 Sponsor tickets• Logo projected onto gallery wall at the event• Logo recognition on website and event signage*

Premier Sponsor: $10,000 ($9,000 tax deductible)• Opportunity to display company logo on lit bars• 20 Sponsor tickets• Recognition on website and event signage*

Marquee Sponsor: $5,000 ($4,500 tax deductible)• 10 Sponsor tickets• Recognition on website and event signage*

Cocktail Sponsor: $3,000 ($2,800 tax deductible)• 4 Sponsor tickets• Signature Event Cocktail named and advertised for you• Recognition on website and event signage*

VIP Sponsor: $1,500 ($1,300 tax deductible)• 4 Sponsor tickets• Recognition on website and event signage*

Capitol Sponsors: $500 ($400 tax deductible)• 2 Sponsor tickets• Recognition on website and event signage*

Individual Ticket: $150 ($100 tax deductible)• 1 ticket

Ticket Angel: $150 ($150 tax deductible)• Sponsor one individual ticket for a parent/caregiver to attend

National Brain Tumor Society and Children’s National Medical Center (CNMC) are tax-exempt 501(c)(3) charitable organizations. National Brain Tumor Society’s 501(c)3#: 04-306-8130 Children’s Hospital Foundation’s 501(c)3 #: 52-164-0402

* All promotional benefits subject to sponsor commitment prior to production

Proceeds to Benefit

Sarah SadidDevelopment AssistantChildren’s Hospital Foundation 301-565-8423 ssadid@childrensnational.org

Kristen Leonard Assistant Director of Community EventsNational Brain Tumor Society 617-391-6898 kleonard@braintumor.org

SPONSORSHIP OPPORTUNITIES

MORE INFORMATION ABOUT SPONSORSHIPS & TICKETS

FF Presenting Sponsor: $50,000 ($48,000 tax deductible) FF Honoree Sponsor: $25,000 ($23,500 tax deductible) FF Premier Sponsor: $10,000 ($9,000 tax deductible) FF Marquee Sponsor: $5,000 ($4,500 tax deductible) FF Cocktail Sponsor: $3,000 ($2,800 tax deductible)

FF VIP Sponsor: $1,500 ($1,300 tax deductible) FF Capitol Sponsors: $500 ($400 tax deductible) FF Individual Ticket: ___tickets @ $150/each ($100 tax deductible) FF Ticket Angel: ___tickets @ $150/each ($150 tax deductible)

Questions?

Sarah Sadid Development Assistant Children’s Hospital Foundation 301-565-8423 ssadid@childrensnational.org

Kristen Leonard Assistant Director of Community Events National Brain Tumor Society 617-391-6898 kleonard@braintumor.org

REGISTRATION FORMSponsorship OpportunitiesPlease print sponsor name exactly as you wish to be listed on promotional materials.*

Sponsor/Company Name: ______________________________________________________________________

Contact Name: _______________________________________________________________________________

Title: _______________________________________________________________________________________

Address: ___________________________________________________________________________________

City, State, Zip: ______________________________________________________________________________

Phone: ____________________________________________________________________________________

Email: _____________________________________________________________________________________

Sponsorship Levels

_ _ _ _

Please email the names of your guests to ssadid@childrensnational.org by Thursday, February 12, 2015.

Payment OptionsFF I cannot attend but would like to make a contribution in the amount of $____________.

FF My check or money order is enclosed for $____________ , payable to National Brain Tumor Society.

FF Please charge my credit card. Circle one: Visa / MasterCard / Amex / Discover

Card #:____________________________________________CVC#: _______ Exp. Date: ______ /________

_________________________________________ __________________________________________ Please print name as it appears on card Signature of Cardholder

Please return form by Monday, February 2, 2015 to: National Brain Tumor Society, Attn: Bella Notte, 55 Chapel Street, Suite 200, Newton, MA 02458For additional event details, or to register online: www.braintumor.org/BellaNotte

Thursday, February 26, 2015Embassy of Italy Washington, D.C.

National Brain Tumor Society and Children’s National Medical Center (CNMC) are tax-exempt 501(c)(3) charitable organizations. National Brain Tumor Society’s 501(c)3#: 04-306-8130 Children’s Hospital Foundation’s 501(c)3 #: 52-164-0402

* All promotional benefits subject to sponsor commitment prior to production

Proceeds to Benefit

Thank you for supporting pediatric brain tumor research

Rev 02/05/15