spring 2014 chem 100 organic synthesis and mechanism - faculty
TRANSCRIPT
Spring 2014
Chem 100 Organic Synthesis and Mechanism
I t t P f M Li T (曹夢麟)Instructor: Prof. Meng-Lin Tsao (曹夢麟)
Office: SE 360Tel: 228-4511 Email: [email protected]
Lectures: T, R 9:00 am – 10:15 am, COB 120
Office hours: MW 10:30am – 11:30 am and by appointments
Spring 2014
Chem 100 Organic Synthesis and Mechanism
TA Sh h i Xi ( i @ d d )TA: Shuhuai Xiang ([email protected])
Dusty Ventura ([email protected])y ( @ )
Al Tramontano ([email protected])
Office hours: TBA
Textbook: P. N. Bruice, Organic Chemistry, Prentice Hall, 6th ed., 2011
Recommended: Bruice Study Guide and Solution’s ManualBruice Study Guide and Solution s ManualOrganic Chemistry Molecular Models Kit
• Course Goals/Objectives• Course Goals/Objectives
This course is designed to help students build a solid knowledge base of common methods and applications in organic synthesis. Reaction mechanisms are emphasized for understanding chemical reactivity and predicting g y p greaction outcomes.
You are expected to read each assigned chapter in BruiceYou are expected to read each assigned chapter in Bruice before the class period in which that chapter is discussed. A successful Chem 100 student will prepare by reading the book, attend lectures, ask questions, and do many practice problems.
H k Y d t d bl i thHomework: You are encouraged to do problems in the textbook. Problem sets will be posted on CROPS each Thursday afternoon and will be collected during the y gsubsequent class.
Exams:Quizzes (chances for extra credits)3 Midt (F b 20 M 20 A 24)3 Midterm exams (Feb 20, Mar 20, Apr 24)Final exam (May 13; comprehensive)
Grading:Homeworks: (all 14) 100 points Midterms: (3 x 100 ) 300 points( ) pFinal Exam: 200 points Total: 600 points
A = 90%; B = 80%; C = 70%; D = 60%; F = 0-59%
A curve may be applied to course grades.A curve may be applied to course grades.
Misc items on syllabus:Misc items on syllabus:
• UCM CROPS: ResourcesAnnouncementsAnnouncementsGradebook
Cl P li i• Class PoliciesAttendance and behavior
A d i I t it P li• Academic Integrity Policy
• Disabilities Services Information
Chem 100 Lecture Schedule (Tentative) – Spring 2014
Date Topic CoveredT 1/21 Syllabus; Carbonyl compds 17 1 2T 1/21 Syllabus; Carbonyl compds 17.1-2
…. Aldehyde & Ketones 18.1-18.10,18.14…. Enolate 19.1-19.3R 2/20 1st Midterm Exam (Ch 17 & 18 )R 2/20 1 Midterm Exam (Ch 17 & 18 )
…. Alkyne 6.1-6.8…. Radicals 12.1-12.9R 3/20 2nd Midterm Exam (Ch 19, 6 & 12 )( , )
…. Redox 20.1-20.4…. Amines&heterocycles 21.1-21.7…. Carbohydrates 22.1-22.6R 4/24 3rd Midterm Exam (Ch 20, 21 & 22 )
…. Amino acids 23.1-23.3…. Nucleic Acids 28.1-28.4; course evaluationT 5/13 Fi l E ( h i )T 5/13 Final Exam (comprehensive)
Organic Chemistry6th Edition
Paula Yurkanis BruicePaula Yurkanis Bruice
Chapter 17
Carbonyl Compounds I
Reactions of eact o s oCarboxylic Acids and
Carboxylic Acid DerivativesDerivatives
9
Class II carbonyl compounds:
will be discussed in Ch. 18
Class I carbonyl compounds:
How to name a carbonyl compound?O
OH
O
O
O
propane propanoic acidOH
propanoic anhydrideO
O
H
O
Cl
O
NH
propanalH
propanoyl chlorideCl
propanamideNH2
O O
O
N
propanone methyl propanoateO
propanenitrile
OHow to name a carbonyl compound?
O
Cl
cyclohexane
O
cyclohexanecarbonyl chloride
OO
OH
O
NH2
cyclohexanecarboxylic acid
NH2
cyclohexanecarboxamide
ON
O
methyl cyclohexanecarboxylate cyclohexanecarbonitrile
OHow to name a carbonyl compound?
O
Cl
benzene
O
benzenecarbonyl chloride
O
benzoyl chloride
O
OH
O
NH2
benzenecarboxylic acid benzenecarboxamidebenzoic acid benzamide
ON
O
methyl benzenecarboxylate benzenecarbonitrilemethyl benzoate benzonitrile