stabimed & helizyme manual instrument cleaning and disinfection taiwan april 16, 2013
TRANSCRIPT
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Stabimed & HelizymeManual Instrument Cleaning and Disinfection
Taiwan April 16, 2013
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OPM - Infection Control | Martin Madrid | Stabimed | Page 2
International Standards for Reprocessing of Medical Devices
Cleaning Disinfection Sterilization
Cleaning Disinfection / Sterilization
Cleaning Disinfection
Critical Items: Medical devices that penetrate sterile tissue,
cavity, or blood (e.g. surgical instruments, cardiac catheters)
Semi-Critical Items: Medical devices that come in contact with
intact non-sterile mucous membranes (e.g. endoscopes)
Non-Critical Items: Medical devices that come in contact with
intact skin (e.g. EKG leads, non-invasive ultrasound probes)
Methods:• Steam
(Autoclave)• Ethylene
Oxide• H202
Gas/Plasma
• Ozone
STEPS:
STEPS:
STEPS:
SP
AU
LD
ING
’S C
LA
SS
IFIC
AT
ION
> Enzyme Cleaner > Liquid Chemical Germicide
> Enzyme Cleaner > Liquid Chemical Germicide for heat sensitive
> Enzyme Cleaner > Liquid Chemical Germicide
where USA & EU are different!
(includes dental devices)
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OPM - Infection Control | Martin Madrid | Stabimed | Page 3
USED INSTRUMENT > Potentially contaminated = DANGEROUS
Method Result
Cleaning and Disinfection Reduced number of pathogens, proteins are removedSafe for handling = safety for the staff
Inspection and care Instrument is proper functioning
Sterilization Safe for use = Safety for the patient
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The Cleaning Process:1st step: Softening. This is a prerequisite for cleaning effectively. This is based on general state-of-the-art principles by means of special liquids/detergents that may loosen dirt, biofilm a little and/or dissolve any bacteria that are present.
2nd step: Loosening. Loosening the softened dirt is part of the detachment process. At this stage, the softening process is not yet complete over the whole area. This means that parts of instrument are still coated with dirt.
3rd step: Detachment. Once the softening/loosening is complete, it becomes possible to detach any dirt coating the surface, for example by means of rinsing, possibly supported by brushing or other recognized procedures (e.g. water jets or ultrasound techniques).
4th step: Removal. As a final step removal of dirt is ensured by rinsing off residues. Recontamination of the instrument must be avoided. The instrument must be protected form recontamination of dirt which was previously removed from the same or other instruments.
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OPM - Infection Control | Martin Madrid | Stabimed | Page 5
Detergents – How they work
reduce the surface tension of water
support softening, loosening and detaching of dirt
disperse dirt (bind dirt in the solutions, preventing recontamination)
SoilInstrument surface
Instrument surface
Instrument surface
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OPM - Infection Control | Martin Madrid | Stabimed | Page
Danger – Bacterial replication in a cleaning solution without disinfection properties
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Bacteria double their number every X minutes. After certain hours bacteria can grow to a dangerous number.A reliable disinfectant kills bacteria and prevents bacterial growth in the bath.
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OPM - Infection Control | Martin Madrid | Stabimed | Page 7
20 min. 2 Bacteria40 min. 41 hr. 8 E.Coli or 2 hrs. 64 Salmonella3 hrs. 512 double their number4 hrs. 4.096 every5 hrs. 32.768 20 minutes6 hrs. 262.1446 hrs. 40 min. 1.048.576 Bacteria
Bacterial replication is fast
Disinfection is needed immediately before the bacteria grows to a dangerous number!
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Cleaning and Disinfection of Instruments
starting point
cleaning beforedisinfection reduces visible blood to zero
disinfection with aldehydes or alcoholbefore cleaning settles and bleaches protein
Surface of instrument
Surface of instrument
Surface of instrument
blood
blood
germs
germs
germs
invisible
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Aldehydese. g. Formaldehyde, Glutaraldehyde, Phthalaldehyde, Aldehyde releasing compounds
Efficacy: bactericidal, fungicidal, tuberculocidal, virucidal (enveloped and non-enveloped viruses), sporicidal
Application area: surface and instrument disinfection (in particular flex. endoscopes)
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Pro Cons
Effective, even in the presence of blood
Irritates skin and respiratory tract
Easily biodegradable May cause allergies, contact allergies
Material compatible Formaldehyde is categorized as cancerogenic
World standard for high-level disinfection of flexible endoscopes
Protein fixing => no longer used for heat-resistant instruments
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Aldehydes and Protein-fixing
Aldehydes
contaminated with blood
after machine cleaning
after manual disinfection
after steam sterilization
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SHEA: Society for Healthcare Epidemiology of America (2010)
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Patient Risks: Facts about Prions & CJD (Creutzfeldt-Jakob Disease)
• Prions are infectious agents composed of protein in a misfolded form. • When a prion enters a healthy organism, it induces existing, properly folded
proteins (found most abundantly in the brain) to convert into the disease-associated, prion/misfolded form; the prion acts as a template to guide the misfolding of more proteins into prion form.
• The abnormal folding of the prion proteins leads to brain damage and the characteristic signs and symptoms of the disease. Prion diseases are usually rapidly progressive and always fatal.
• Creutzfeldt-Jakob Disease (CJD) is a human prion disease. It is a neurodegenerative disorder that is rapidly progressive and always fatal. Infection with this disease leads to death usually within 1 year of onset of illness.
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OPM - Infection Control | Martin Madrid | Stabimed | Page 13
Patient Risks: Facts about Prions / CJD UK: Instruments must be discarded and burned after use for surgery on known
CJD-patients! Þ Instrument tracking becomes more and more relevant.
Prions can withstand heat e.g. autoclaving 121 °C – 21min. Therefore steam sterilisation at 134 °C is recommended.
Prions / Proteins are stabilized on metal surfaces of surgical instruments by protein fixing agents such as Aldehydes, Alcohols or heat.
after decontamination with aldehydes autoclaving even 134 °C / 18 minutes is not effective
Conclusion: Aldehydes are no longer recommended for reprocessing heat resistant (134°C) surgical instruments!
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OPM - Infection Control | Martin Madrid | Stabimed | Page 14
Aldehyde free disinfectants prevent protein-fixing
Aldehydes
Alkylamines & Phenolsprevent
protein-fixing
BETTER ALTERNATIVE:
contaminated with blood
after machine cleaning
after manual disinfection
after steam sterilization
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OPM - Infection Control | Martin Madrid | Stabimed | Page
AlkylaminesActive Ingredients with Excellent Cleaning Property
Cocospropylene diamine
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Microbicidal Efficacy of an Alkylamine Based Disinfectant (Stabimed)
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EN 14653
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New DGHM-Test quantitative carrier test 1.9.2001 / EN 14653:2008vgl. Hyg. Med. 27. Jahrgang 2002 – Heft 10, 384-386
Test germM. terrae
Organic loade.g. 0,3% albumin and sheep erythrozyts
Old: quantitative suspension test
New: quantitative carrier test
Disinfectant solution
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Active ingredients can attack germs form all directions
Active ingredients can attack from one direction, only!
• Diffusion• Surface tension• Chemical structure of active ingredient
Suspension test vs. Practical Carrier test
In the practical carrier test the efficacy of a product can be approved, even if there is visible contamination !
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OPM - Infection Control | Martin Madrid | Stabimed | Page 20
EN 14653:2008 : Active Ingredients in Instrument Disinfectants
Efficacy without
Phase 2 Step 2 Class of Active Ingredient
Efficacy incl. TbB Phase 2 Step 2
Aldehydes
Phenols
Alkylamines
- QAC, Biguanides
Combination of Alkylamins,
QAC
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www.cdc.gov/biosafety/publications/bmbl5/bmbl5_appendixb.pdf
Standards for re-processing flexible endoscopes (heat sensitive)
Disinfectant must be also be capable of inactivating some bacterial spores
Disinfectant must be able to pass Practical Carrier Test and inactivate Mycobacteria
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High Level Disinfectant - an agent that kills all microbial organisms but not necessarily large numbers of bacterial spores
• Used as an acceptable alternative to Sterilization for reprocessing heat sensitive SEMI-CRITICAL medical devices such as flexible endoscopes.
• Some capable of Chemical Sterilization when reusable medical devices are soaked for longer periods of time (5 to 12 hours)---only as last resort and not to be performed if other sterilization methods capable of being biologically monitored are available (e.g. steam, ethylene oxide, hydrogen peroxide gas plasma)
Definitions:
American National Standard for Reprocessing of Medical Devices (ANSI/AAMI ST79:2010)
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Limitations of Gluteraldehyde (‘high level disinfectant’)
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Limitations of Gluteraldehyde (‘high level disinfectant’)
• They are ineffective against Clostridial Endospores such as Clostridium Tetani (Tetanus) and Clostridium Perfringens (Gangrene)
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Effective Marketing Talk !
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Risk of Infection: Are HLDs really necessary for flexible endoscopes? Are bacterial spores really a threat?
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REFERENCES:
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Risk of Infection: Are HLDs really necessary for flexible endoscopes? Are bacterial spores really a threat?FROM CDC 2008 REPORT:
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So which is the real threat to patients?
BACTERIAL SPORES PRIONS
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Cleaning and disinfection in one step!
To minim
ize risks in
case
of sharp in
juries
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Stabimed Video
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EUROPECleaning and Disinfection in one step (Alkylamines)
vs.
USA1st Precleaning
2nd Disinfection 2.4% activated Gluteraldehyde
15 minutes 45 minutes (acc. to FDA*, 2009)
15 minutes
10 minutes
avoidable RISK
Efficacy against Mycobacteria:
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Disinfection by Immersion
Modern instrument disinfectants (in particular amines e.g. Cocospropylene diamine) clean and disinfect in one step.
Process:
Disassemble complex instruments (according to the recommendations
of the manufacturer)
Open jointed instruments
Immerse instruments completely
Wait until the contact time has fully elapsed
Use brushes as recommended by the manufacturer
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Which Process Do You Prefer?
Cleaning – not safe for the staff Risk of infection by sharp injuries
Cleaning and disinfection in one step
a) Time needed: 55 minutes
b) Time needed: 15 minutes (at 2% concentration)
Disinfection in 2.4% Glutardialdehyde solution
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Stabimed® : For cleaning and disinfection in one step of surgical instruments, medical devices, rigid and flexible endoscopes
Occupational Health and
Safety
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Stabimed Dosing table15 mins30 mins60 mins
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Preparation of 2 litres of 2 % disinfectant solution
1‘960 ml cold water+ 40 ml concentrate
= 2‘000 ml total volume
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Concentrates are economic: 1 Litre of concentrate gives 50 liters of a 2% ready-to-use working solution
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10 liters
10 liters
10 liters
10 liters
10 liters
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Limitations of Stabimed One Step Method (vs. ready to use solutions)
• Basin of solution for one-step solution needs to be replaced on a daily basis
• 2% concentration: may be less cost effective than ready-to-use solutions of high volume manual reprocessing of instruments
• 1% and 0.5% concentration: more cost effective than ready-to-use solutions however immersion times are longer, thus extending reprocessing times (1% = 30 mins; 0.5% = 60 mins)
• Need to do workflow studies to balance off cost and turn-around time requirements
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One Step Method: Cost Savings start at 1% & 0.5%
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Two Step Method with Stabimed:
• For fast processing time at lowest possible costs for high volume manual instrument reprocessing:
Helizyme for Cleaning 1% (5 mins)
Stabimed for Disinfection 2% (15 mins)
Total time: 20 mins
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COST SAVINGS: (Stabimed as a Disinfectant)
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=
(50 Liters or 13.15 gallons of Cidex)
(1 liter of Stabimed)40ml per 2 liters of water
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COST SAVINGS: (Stabimed as a Disinfectant)
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Manual Instrument Reprocessing
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Contact mainly with diluted ready-to-use working concentration
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Helizyme: Enzymatic Cleaner
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Helizyme: Enzymatic Cleaner
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Helizyme for effective cleaning of flexible endoscopes
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Stabimed Dosing Aid = CONVENIENCE OF
USE
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Material compatibility
+validated
cleaning result
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STABIMED is recommended by Aesculap for its devices
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Stabimed is safe for staff
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Stabimed is biodegradable
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Does Stabimed Meet User Requirements?
Aldehyde-free, so no protein-fixing Excellent material compatibility: recommended by Aesculap Broad efficacy spectrum: bactericidal (incl. MRSA and
mycobacteria-TbB), fungicidal, virucidal against enveloped viruses and effective against Rota-Polyoma- and Adenoviruses
Short re-processing time (2% - 15 mins) Cost-effective (dilutable concentrate) Safe for the staff (passed patch test) Safe for the environment (biodegradable)
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