stage 4 optional modules

8/2/2019 Stage 4 Optional Modules

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Module Outline Form

Module code: CHY8420

Module Title: Organic Synthesis for Drug Targets

Short Title: Organic Synthesis for Drug Targets

0Semester 1 credits: Semester 2 credits:

10Semester 3 credits:

0ECTS credits:

5.0

FHEQ Level : 7

Owning School : Chemistry

Prof. Michael North Lecturer 50

Dr Julian Gary Knight Module Leader 50

Full Name Contributor Description % Contribution

4

Support Staff Requirements:

N/A 0

Other Institution(s): Proportion of teaching %

PreRequisites :

CHY3101 Advanced Organic Chemistry

Code Short Title

CoRequisites :

PostRequisites :

F124 MChem Medicinal Chem (Ind Train) Yes No No

F107 MChem Chemistry with Study in Europe Yes No No

F123 MChem with Hons in Medicinal Chemistry Yes No No

F106 MChm Hon Chemistry (Industrial Training) Yes No No

F103 MChem with Hons in Chemistry Yes No No

F105 MChem Chemistry with study in N America Yes No No

Code Title Optional Compulsory Core

Other Programme Links :

Academic Year:

Equivalent Modules :

ModuleRole(s) :

Programme Links:

Stage

2011/12 Active: Yes

CHY8820 Organic Synthesis for Drug Targets

Max Capacity:999

Date:29/03/2011,08:40AM

Mode : Linear Stand alone : Not Available


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Availability:

Annually

Aims:

To familiarise students with the key strategies for the stereocontrolled synthesis of organic compounds; toprovide practise in identifying and applying such strategies; to exemplify the principles in the context of thesynthesis of drug targets

Module Summary:

The lectures cover the principles of stereocontrol, regioselectivity, and asymmetric synthesis including:directed reactions, the Felkin-Ahn model, chelation control, 1,3-allylic strain, chiral auxiliaries, chiralcatalysis, bidirectional chain synthesis double stereodifferentiation, and chiral amplification.

Outline of Syllabus:

Is the module suitable for study abroad students? No

Intended Knowledge Outcomes:

Intended Skill Outcomes:

Graduate Skills Framework:

Cognitive / Intellectual Skill

P - Present, A - Assessed


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Teaching and learning methods:

Method Number Length Student Hours

Lectures:

Seminars:Tutorials:

Practicals:

Fieldwork:

Private Study:

16 001:00 016:00 016:00

5 001:00 005:00 005:000 0:00 0:00 0:00

0 0:00 0:00 0:00

Class Tests:

Group Learning:

0 0:00 0:00 0:00

0076:00

0 0:00 0:00 0:00

0 0:00 0:00 0:00

Other method(s)

workshops 3 000:00 003:00 003:00

Description Number Length Student Hours Staff Hours

Total Hours : 024:000100:00

Information Literacy

Critical Thinking: Data Synthesis:

Active learning : P Numeracy: A

Literacy: P

Source materials: Synthesise and Present Materials:

Use of Computer Application

Self Management

Self-awareness and Reflection P

Planning & Organisation

Goal setting & action planning: Decision Making:

Personal Enterprise

Innovation and Creativity: Initiative:

Independence: P Adaptability:

Problem Solving A

Budgeting:

Interaction

Communication

Oral: Foreign Languages:

Interpersonal: Written/Other: P

Team Working

Collaboration: Relationship Building:

Leadership: Negotiation:

Peer Assessment/Review:

Application

Occupational Awareness:

Commercial AcumenMarket Awareness: Governance Awareness:

Financial Awareness: Business Planning:

Ethical Awareness: Social, Cultural & Global Awareness

Legal Awareness:


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Timetabling Information:

Approx Student Numbers:

20

Rationale and relationship to learning outcomes:

The course involves the introduction of a set of principles which may be applied to the analysis and designof organic synthesis. These principles are addressed in the 16 lectures. These basic principles areconsolidated in 5 seminars (which are spread out over the course) in which problems, each focussing on aparticular example, and attempted in advance by the students, are discussed. The final series of workshopsinvolve discussion of the application of these principles in the context of total synthesis of drug targets andserve to draw together the various strands of the course.

Stereoselectivity inOrganic Synthesis

G Procter,OxfordChemistry

Primer

Oxford University Press1998

0198559577

No Yes No

Asymmetric Synthesis G Procter Oxford University Press1996

0198557256

No Yes No

Asymmetric Synthesis ofNatural Products

A Koskinen Wiley 1993 0471938483

No Yes No

Principles andApplications ofStereochemistry

M North STP 1998 0751404209

No Yes No

Organic Chemistry J Clayden, NGreeves, SWarren, PWothers

Oxford University Press,2000

0198503466

Yes No No

Title Author Notes ISBN Essent. Bkgrnd. Recmd.

Written Examination 120 2 100

Type

When Set

Comment for assessment

Assessment rationale and relationship:

CHY8820 Organic Synthesis for Drug Targets

Code Short Title

Jointly taught with:

Reading References:

Exams:

Exams Pairing Requirements:

Other Assessment:


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Chemistry Chemistry 100

Academic Cost Centre Jacs Subject Code

01/01/2005Signed by Head of School(s) or nominee:

Immunisation / Allergy Screening (complete only if module is taken by non-clinical students)

Immunisation Should be offered (yes/no

Hepatitis A:

Hepatitis B:

Tetanus:

Allergy Screening:

No

No

No

No

Handbook Text:

General Notes:

Hesa Data:

Internal Resourcing:


6/34

Module Outline Form


Module Title: Advanced Methods in Drug Discovery

Short Title: Advanced Methods in Drug Discovery



0ECTS credits:

5.0

FHEQ Level : 7


Dr Celine Cano Other Staff 10

Prof. Roger John Griffin Other Staff 10

Dr Ian Robert Hardcastle Module Leader 80


4


N/A 0


PreRequisites :

CHY3101

CoRequisites :

PostRequisites :

F124 MChem Medicinal Chem (Ind Train) No Yes No


F123 MChem with Hons in Medicinal Chemistry No Yes No






Availability:

Annually

Academic Year:


ModuleRole(s) :

Programme Links:

Stage

2011/12 Active: Yes

Max Capacity:999

Date:29/03/2011,08:43AM



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Aims:

To demonstrate the role of combinational synthesis in drug discovery; to provide students with anunderstanding of the historical development of combinational methods; to introduce the concepts of solid-phase synthesis and resin- assisted synthesis; to provide students with an understanding of radioisotopes inmedical imaging.

Module Summary:

This module gives a thorough overview of the methods used to discover drugs in use today. The synthesis

and use of combinatorial libraries of both peptides and small drug-like molecules is covered in detail. Thesynthesis and uses of radioisotopically labelled drugs is discussed in depth.


Is the module suitable for study abroad students? Yes






Critical Thinking:


Data Synthesis:


Literacy: P



Self Management





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Lectures:

Seminars:

Tutorials:Practicals:

Fieldwork:

Private Study:

22 001:00 022:00 022:00

2 001:00 002:00 002:00

0 0:00 0:00 0:000 0:00 0:00 0:00

Class Tests:

Group Learning:

0 0:00 0:00 0:00

0076:00

0 0:00 0:00 0:00

0 0:00 0:00 0:00

Other method(s)


2 lectures per week. Data projector required. Preference for BEDB LT3 or BTC


20


CHY8821 Modern Methods in Drug Discovery 1

Code Short Title Semester


Total Hours : 024:000100:00

Personal Enterprise

Innovation and Creativity: Initiative: P


Problem Solving A

Budgeting:

Interaction

Communication


Interpersonal: P Written/Other: A

Team Working




Application


Commercial Acumen

Market Awareness: Governance Awareness:Financial Awareness: Business Planning:


Legal Awareness:


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Solid - supportedcombinatorial and parallellsynthesis of small -molecular -weightcompound libraries

D Obrechtand JMVillalgordo

Pergamon , 1998 0080432573

Yes No No

Medicinal ChemistryPrinciples and Practice

FD King RSC 2002 0854046131

No No Yes

Combinational Chemistry NK Terrett Oxford 1998 019850219

2

Yes No No



Type

When Set


Other 1 20

Type When Set % of formal assessment



CHY8821 Modern Methods in Drug Discovery

Code Short Title






Hepatitis A:

Hepatitis B:

Tetanus:

No

No

No

Reading References:

Exams:


Other Assessment:

Hesa Data:



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Allergy Screening: No

Handbook Text:

General Notes:


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Module Outline Form


Module Title: Further Organic Chemistry

Short Title: Further Organic Chemistry



0ECTS credits:

5.0

FHEQ Level : 7


Dr Julian Gary Knight Lecturer 50

Dr Michael John Hall Module Leader 50


4


N/A 0


PreRequisites :


Code Short Title

CoRequisites :

PostRequisites :









Availability:

Academic Year:


ModuleRole(s) :

Programme Links:

Stage

2011/12 Active: Yes

Max Capacity:999

Date:29/03/2011,08:44AM



12/34

Annually

Aims:

To introduce and develop the concepts of thermal and photochemical pericyclic reactions and FrontierMolecular Orbital (FMO) theory; to describe the methods used to determine the mechanisms of suchreactions; to discuss radical chemistry; to explore reactions involving radicals and ions in cyclisationreactions.

Module Summary:There are numerous reactions in organic chemistry that involve cyclic transition states and these have awide range of applications in synthesis, biological processes, industry and mechanistic study. This modulewill explore the underlying chemistry of such reactions, their theoretical basis and their utility.







Critical Thinking:


Data Synthesis:



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Lectures:

Seminars:

Tutorials:

Practicals:Fieldwork:

Private Study:

16 001:00 016:00 016:00

0 0:00 0:00 0:00

0 0:00 0:00 0:00

0 0:00 0:00 0:00

Class Tests:

Group Learning:

0 0:00 0:00 0:00

0080:00

0 0:00 0:00 0:00

0 0:00 0:00 0:00

Other method(s)

Workshops 4 001:00 004:00 004:00

Description Number Length Student Hours Staff Hours


Total Hours : 020:000100:00


Literacy: P



Self Management




Personal Enterprise



Problem Solving A

Budgeting:

Interaction

Communication



Team Working




Application


Commercial Acumen

Market Awareness: Governance Awareness:



Legal Awareness:


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2 lecture slots per week (data projector required)


15

Rationale and relationship to learning outcomes:In lectures student learn advanced concepts in the organic chemistry of reactions involving cyclic transitionstates which, encompasses synthetic, theoretical and mechanistic principles. In workshops they applylearnt material to solve problems.

Frontier Orbitals andOrganic ChemicalReactions

I Fleming

0471018198

No Yes No

Organic Reactions andOrbital Symmetry

Out of print; copiesavailable from theRobinson library

No Yes No

Organic Chemistry

Oxford University Press2000

0198503466

Yes No No



Type

When Set








Hepatitis A: No


Reading References:

Exams:


Other Assessment:

Hesa Data:



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Hepatitis B:

Tetanus:

Allergy Screening:

No

No

No

Handbook Text:

General Notes:


16/34

Module Outline Form


Module Title: Advanced Topics in Contemporary Physical Chemistry

Short Title: Advanced Topics



0ECTS credits:

5.0

FHEQ Level : 7


Dr Ulrich Baisch Lecturer 30

Dr Benjamin Richard Horrocks Lecturer 30

Prof. Anthony Harriman Module Leader 40


4


N/A 100


PreRequisites :

CHY3201 Advanced Physical Chemistry

CHY2201 Physical Chemistry

Code Short Title

CoRequisites :

an industrial placement

PostRequisites :








Availability:

Academic Year:


ModuleRole(s) :

Programme Links:

Stage

2011/12 Active: Yes

Max Capacity:999

Date:29/03/2011,08:45AM



17/34

Annually

Aims:

To describe modern advances in applied physical chemistry by reference to three selected topics; namely,advanced electrochemistry, crystallography and electron-transfer reactions. Included are the basicprinciples involved in each topic and a logical development of the subject. Attention is given to modernaspects of the field and to the application of that topic to contemporary research issues. Emphasis will begiven to practical aspects of the technique, without recourse to detailed mathematical approaches.

Module Summary:






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Critical Thinking:


Data Synthesis:

Active learning : P Numeracy: P

Literacy: P



Self Management




Personal Enterprise


Independence: P Adaptability: P

Problem Solving A

Budgeting:

Interaction

Communication


Interpersonal: Written/Other: A

Team Working




Application


Commercial Acumen




Legal Awareness:


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Lectures:

Seminars:

Tutorials:

Practicals:

Fieldwork:

Private Study:

24 001:00 024:00 024:00

3 001:00 003:00 003:00

0 0:00 0:00 0:00

1 001:00 001:00 001:00

Class Tests:

Group Learning:

1 001:00 001:00 001:00

0070:00

0 0:00 0:00 0:00

1 001:00 001:00 001:00

Other method(s)


2 lectures per week and one seminar/workshop per month


15


Students acquire knowledge and understanding through lectures and by the way of research articlesavailable on the web. Handouts will provide additional knowledge. Students will undertake organised tripsto research labs to see the various techniques in operation and will have opportunity to talk to specialistsabout these experimental protocols. Research articles will be discussed both formally and informally andused to illustrate the formal lectures. Students will be directed to key websites where additional informationcan be found in a more user-friendly manner than advanced textbooks.

Charge and EnergyTransfer Dynamics inMolecular Systems

V May & OKuhn

Wiley-VCH 3527296085

No Yes Yes

Crystallization JW Mullin Butterworth-HeinemannOxford, 1993

0750611294

No Yes Yes

Molecular Electronics J Jortner &

MA Ratner

IUPAC/Blackwell Science

Ltd

063204284

2

No Yes Yes

Electrode Potentials RG Compton OU Chemistry Series 0198556845

No Yes Yes

Electrochemical Methods AJ Bard & LRFaulkner

John Wiley & Sons; 2ndEdition

0471043729

No Yes Yes

Dynamic Electrochemistry AC Fisher OU Chemistry 0749251891

No Yes Yes


Written Examination 120 2 40 Open book examination

Type

When Set



Reading References:

Exams:


Other Assessment:

Total Hours : 030:000100:00


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Other 2 30 Research Assignment (week 3) A set of threeassignments, developed around a researchtopic closely related to the taught material

Other 2 30 Assignment (week 6) combination of threeseparate assignments set by individual lecturer









Hepatitis A:

Hepatitis B:

Tetanus:

Allergy Screening:

No

No

No

No

Handbook Text:

General Notes:

Hesa Data:



21/34

Module Outline Form


Module Title: Catalyst Application and Design

Short Title: Catalyst Application and Design



0ECTS credits:

5.0

FHEQ Level : 7


Dr Robert John Errington Lecturer 50

Dr Simon Doherty Module Leader 50


4


PreRequisites :

CHY3301 Advanced Inorganic Chemistry

Code Short Title

CoRequisites :

PostRequisites :





5099F MSc Drug Chemistry (FT) Yes No No



5099P MSc Drug Chemistry (PT) Yes No No



Availability:

Annually

Academic Year:


ModuleRole(s) :

Programme Links:

Stage

2011/12 Active: Yes

Max Capacity:999

Date:29/03/2011,08:45AM



22/34

Aims:

To use selected industrial processes and environmental challenges to illustrate current approaches tocatalyst development

Module Summary:






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Lectures:

Seminars:

Tutorials:

Practicals:

Fieldwork:

Private Study:

24 001:00 024:00 024:00

0 0:00 0:00 0:00

0 0:00 0:00 0:00

0 0:00 0:00 0:00

Class Tests:

Group Learning:

0 0:00 0:00 0:00

0076:00

0 0:00 0:00 0:00

0 0:00 0:00 0:00

Other method(s)

Total Hours : 024:000100:00




Critical Thinking:


Data Synthesis:


Literacy: P



Self Management




Personal Enterprise

Innovation and Creativity: Initiative:


Problem Solving

Budgeting:

Interaction

Communication


Interpersonal: Written/Other: A

Team Working




Application


Commercial Acumen




Legal Awareness:


24/34


2 lectures per week


20-25


Much of the key material is conceptual and is suited to delivery via lectures. The problem solving sessionsare designed to complement the lectures and provide the students with an increased appreciation of thetopics involved

Applied Homogeneous

Catalysis withOrganometallicCompounds

B. Cornils,

W. Hermann

2005 352729288

8

No No Yes

Homogeneous CatalysisUnderstanding the Art

P. W. N. vanLeeuwen

2004 1402031769

Yes No No



Type

When Set





Chemistry 100

Contributing School FTE Proportional split (%)




Hepatitis A:

Hepatitis B:

No

No


Reading References:

Exams:


Other Assessment:

Hesa Data:



25/34

Tetanus:

Allergy Screening:

No

No

Handbook Text:

General Notes:


26/34

Module Outline Form


Module Title: Further Inorganic Chemistry

Short Title: Further Inorganic Chemistry



0ECTS credits:

5.0

FHEQ Level : 7


Dr Robert John Errington Lecturer 33

Prof. Andrew Houlton Lecturer 33

Dr Keith James Izod Module Leader 34


4


N/A 0


PreRequisites :

CHY3301 Advanced Inorganic Chemistry


Code Short Title

CoRequisites :

PostRequisites :









Academic Year:


ModuleRole(s) :

Programme Links:

Stage

2011/12 Active: Yes

Max Capacity:999

Date:29/03/2011,08:46AM



27/34

Availability:

Annually

Aims:

To present a series of short courses on advanced topics in contemporary inorganic chemistry; to show howfundamental aspects of inorganic chemistry are being used to develop new concepts in chemistry andapplied in modern chemical industry.

Module Summary:

This module shows how concepts learnt in earlier stages of the students studies are used in moderninorganic chemistry with an emphasis on contemporary research topics. The module will comprise 3different, but related, aspects of inorganic chemistry








Critical Thinking:


Data Synthesis:


Literacy: P



Self Management



28/34



Lectures:Seminars:

Tutorials:

Practicals:

Fieldwork:

Private Study:

24 001:00 024:00 024:000 0:00 0:00 0:00

0 0:00 0:00 0:00

0 0:00 0:00 0:00

Class Tests:

Group Learning:

0 0:00 0:00 0:00

0076:00

0 0:00 0:00 0:00

0 0:00 0:00 0:00

Other method(s)


3 lectures per week. Data projection required.


12



Total Hours : 024:000100:00



Personal Enterprise


Independence: P Adaptability: P

Problem Solving A

Budgeting:

Interaction

Communication



Team Working




Application

Occupational Awareness:Commercial Acumen




Legal Awareness:


29/34

This module presents a diverse range of topics in inorganic chemistry. Some of the topics build on modulespresented at Stage 3 but take the topic to a more advanced level. Others are topics to which the studenthas never been exposed before. All of the topics represent contemporary research areas in inorganicchemistry and are suitable for advanced students wanting to specialise in inorganic (or allied) chemistry.Students will acquire their knowledge and understanding through lectures and problem sheets.


Type

When Set








Hepatitis A:

Hepatitis B:

Tetanus:

Allergy Screening:

No

No

No

No

Handbook Text:

General Notes:

Reading References:

Exams:


Other Assessment:

Hesa Data:



30/34

Module Outline Form


Module Title: Functional Molecules

Short Title: Functional Molecules



0ECTS credits:

5.0

FHEQ Level : 7


Dr Andrew Christopher Benniston Lecturer 50

Prof. Anthony Harriman Module Leader 50


4


N/A 0


PreRequisites :

CHY3001 Advanced Practical Chemistry

Code Short Title

CoRequisites :

PostRequisites :








Availability:

Annually

Academic Year:


ModuleRole(s) :

Programme Links:

Stage

2011/12 Active: Yes

Max Capacity:999

Date:29/03/2011,08:47AM



31/34

Aims:

To introduce the basic principles involved in the design, synthesis and application of molecular systemsused for a variety of purposes and to develop new materials

Module Summary:

The course is intended to introduce students to the concept of designing a molecular system for a particularpurpose, e.g. the quantitative detection of glucose in blood. This will be followed by a careful considerationof how to synthesise an appropriate molecule equipped with all the necessary functions to carry out itsintended purpose. The final component deals with how to test the system under operating conditions.








PCritical Thinking:


PData Synthesis:


Literacy: P

Source materials: Synthesise and Present Materials: A

Use of Computer Application A

Self Management




Personal Enterprise

Innovation and Creativity: P Initiative: P


Problem Solving A

Budgeting:


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Lectures:

Seminars:

Tutorials:

Practicals:

Fieldwork:

Private Study:

24 001:00 024:00 024:00

0 0:00 0:00 0:00

0 0:00 0:00 0:00

0 0:00 0:00 0:00

Class Tests:

Group Learning:

0 0:00 0:00 0:00

0076:00

0 0:00 0:00 0:00

0 0:00 0:00 0:00

Other method(s)


2 lectures per week


15


Students acquire knowledge and understanding through lectures and problem sheets. Fundamentals will bebuilt upon rapidly to take the students from basic ideas to the design of a suitable prototype and itssubsequent synthesis and testing.

CHY8826 Functional Molecules 1

Code Short Title Semester


Reading References:

Total Hours : 024:000100:00

Interaction

Communication



Team Working

Collaboration: P Relationship Building: P



Application


Commercial Acumen




Legal Awareness:


33/34

Modern methods oforganic synthesis

0521778301

No No Yes

0632024291

No No Yes

Molecular design andbioorganic catalysis

0792340248

No No Yes

How to tackle organicsyntheses

O Meth-Cohn No No Yes

Chemical Sensors andBiosensors

B R Eggins 0471899143

No Yes No



Type

When Set


Coursework 1 50




CHY8826 Functional Molecules

Code Short Title

Chemistry Physical Chemistry 100





Hepatitis A:

Hepatitis B:

Tetanus:

Allergy Screening:

No

No

No

No

Exams:


Other Assessment:

Hesa Data:



34/34

Handbook Text:

General Notes:

stage 4 optional modules

Documents