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Start (or continue) going to TA sections. Come to R ’ s and/or TAs office hours 2130 Pac Hall Tu 2:30-3:30 W 2: 30 -3: 30 . details on course web site:. http://course.ucsd.edu/rhampton/bibc102. Warburg Effect. the Warburg effect is the observation that most cancer cells - PowerPoint PPT Presentation

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rh

Lecture 6 Slides

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Go to TA sections; challenge them!

Come to R’s and/or TAs office hours2130 Pac Hall Mon 2-3

Tue 2-3

details on course web site:

http://course.ucsd.edu/rhampton/bibc102

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Warburg Effect

the Warburg effect is the observation that most cancer cellspredominantly produce energy by a high rate of glycolysisfollowed by lactic acid fermentation in the cytosol

Otto HeinrichWarburg

1931 Nobel Prizein Medicine

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Warburg Effect

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fig 14-10

Gettingother sugarsinto theglycolyticpathway

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pg 545

A second route for fructose (in liver)

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Glycogen: nature’s sugar bowl

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fig 14-11 more about glycogen later

Liberating glucose units from glycogen

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From glycogen to glycolysis…

phosphogluco-mutase

another mutase…

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fig 14-1

Now what?

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fig 14-1

Now what?

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fig 14-1

Now what?

Fermentation: anaerobicmetabolism of glucosewithout oxidation...

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pg 547

LDH converts pyruvate to lactate, restoring the pool of NAD+

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pg 547

LDH converts pyruvate to lactate, restoring the pool of NAD+

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pg 547

ethanol production: another NAD+ restoration strategy

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fig 14-14

Thiamine pyrophosphate (TPP): an activated carbon

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fig 14-14

Thiamine pyrophosphate in ethanol production

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fig 14-14

TPP as a carbanionnucleophilein pyruvate metabolism

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fig 14-14

TPP as a carbanionnucleophile in pyruvate metabolism

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fig 14-14

TPP as a carbanionnucleophile in pyruvate metabolism

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TPP-mediated enzymatic reactions

TPP is all about carbonyl activationtable 14-1

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The glycolysis energy landscape

(pyruvate set to 0)

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Regulated glycolytic enzymes

hexokinse (and glucokinse)

phosphofructokinase (PFK-1)

pyruvate kinase

regulated by G6P allosterically

liver isozyme is glucokinase, different

regulated by ATP, citrate, and fatty acids

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The glycolysis energy landscape

(pyruvate set to 0)

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regulation of hexokinase: isozymes can differ

fig 15-12

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fig 15-14

PFK-1 :a rightfancy enzyme!

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fig 15-14

PFK-1: allosteric regulation by ATP, etc…

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PFK-1: allosteric regulation by ADP, etc…

xxx

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fig 15-14

FPK-1 has multiple allosteric regulators

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fig 15-14

Our book’s notation for regulators

inhibition activation

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fig 15-14

PFK-1 has multiple allosteric regulators

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fig 14-21

Glucose asa source ofother stuff

Pentosephosphatepathway

oxidative reactions

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fig 14-21

Pentosephosphatepathway

oxidative reactions

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fig 14-21

Pentosephosphatepathway

oxidative reactions

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fig 14-21

Pentosephosphatepathway

oxidative reactions

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fig 14-22

Pentose phosphate pathway: non-oxidative rxns

all movementof carbonyl groupsto and fro…

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fig 14-22

Pentose phosphate pathway: non-oxidative reactions

2C

2C

2C

3C2C

3C

end of lecture 6

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pg 547

LDHconverts pyruvateto lactate, restoring the pool of NAD+

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