stefan braunewell 1 a european project on patient-specific modeling and simulation of fus in moving...
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Stefan Braunewell 1
A European project on patient-specific modeling and simulation of FUS in moving organs
Stefan BraunewellFraunhofer MEVIS - Institute for Medical Image Computing, Bremen
Jenny Dankelman, Thomas Langø, Jürgen Jenne, Michael Müller, Yoav Levy, Mario Bezzi, Christine Tanner, Calin Tiu, Daniel Outmazguine, Matthias Günther, Andreas Melzer, Tobias Preusser
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Stefan Braunewell 2
• Reflection, refraction, absorption, cavitation
• Heat transfer, tissue reaction
• Cooling by blood flow and perfusion
• Breathing motion
• Occlusion by ribcage
Focused Ultrasound in the LiverFocused Ultrasound
Computer simulation required for reliable outcome prediction
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Stefan Braunewell 3
Goal of FUSIMO
Develop, implement and validate a multi-level model for FUS simulation in moving abdominal organsFUSIMO software system aids in: Assessing feasibility Optimizing outcome Detecting risks Monitoring progress, tracking deviations Training
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Stefan Braunewell 4
Therapy planning, prediction and monitoring
Functional organ modeling
Model for ultrasound propagation
Motion model for abdominal organs
Patient specific data
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Stefan Braunewell 5
Intra-operative ultrasound
On-line
Prediction of Respiratory Motion
Generic 4D respiratory motion model
Off-line
4DMRI toobserve organ
motion
Quantify organ motion
for population
Prediction
On-line
Image of patient
Pre-therapy
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Stefan Braunewell 6
Incorporation of motion
Heterogeneous mediaDeactivation of elements
US and temperature simulationRib
Target
XD
[mm]
[mm]
[mm]
[mm]
oC
oC
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Stefan Braunewell 7
Parameter identification
Temperature along lesion
Temperature across lesion
MR thermometry of sonication in agar gel
Simulated sonication after recalibration
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Stefan Braunewell 8
Functional Modeling
• Cooling effects due to vessels
• Prediction of supply and drainage areas for blood flow
• Prediction and monitoring of tissue damage
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Stefan Braunewell 9
Simulation results
Pressure
Temperature Damage Risk
Planning Image
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Stefan Braunewell 10
Integrated Software System
• Segmentation• Preview of presumed
motion• Interactive Planning• Exploration of Results• Progress monitoring• Assessment, training
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Stefan Braunewell 11
Multi-level validation
• Volunteers• Motion tracking• Motion model• MR imaging protocols
• Phantoms• US, temperature simulation• Steered sonications
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Stefan Braunewell 12
System validation
• Validate and optimize workflow• Positioning using Innomotion Robot Arm• Thiel cadavers
- Motion model- Perfusion- Steered sonications
Renal artery perfusion in cadaver
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Stefan Braunewell 13
Fraunhofer
MEVIS
University of
DundeeTU Delft
MediriIBSm
mInSightec Ltd
General Electrics
Universita LaSapien
za
ETH Zurich
Fundatia MEDIS
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Stefan Braunewell 14
FUSIMO Take Home Message
Integrated software system for FUS in moving organs Assessing feasibility Optimizing outcome Detecting risks Monitoring progress, tracking deviations Training