stem cell concept pg. 721. signal transduction pathways and cell differentiation specialized cell...
Post on 19-Dec-2015
216 views
TRANSCRIPT
![Page 1: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/1.jpg)
Stem Cell Concept
Pg. 721
![Page 2: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/2.jpg)
Signal Transduction Pathways and Cell Differentiation
Specialized cell type(neuron, skin cell, red blood cell, etc.)
Stem Cell
![Page 3: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/3.jpg)
Blood Cell Formation
![Page 4: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/4.jpg)
Erythropoietin (Epo)
![Page 5: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/5.jpg)
(Epo)
![Page 6: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/6.jpg)
Red Blood Cell Development
![Page 7: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/7.jpg)
EPO
Synthesis of proteins that stimulate Red Blood Cell development andprevent apoptosis
![Page 8: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/8.jpg)
Negative Regulation of JAK/STAT Pathway
![Page 9: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/9.jpg)
Mutant EPO Receptor
PP
Signal toActivate
![Page 10: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/10.jpg)
Seven-Pass ReceptorsAdrenalineGlucogonTSH, LH
Cell TypesHeart muscleSkeletal muscleThyroidOvaryKidneyIntestinal epithelia
ContractionGlycogen breakdownHormone secretionWater retentionIon transportPg. 546
![Page 11: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/11.jpg)
Activation of Galpha Subunit
![Page 12: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/12.jpg)
Synthesis of cyclic AMP
ATP
cyclic AMP
Adenylyl Cyclase
Pg. 550
Protein Kinase A (PKA)CFTROther Proteins
![Page 13: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/13.jpg)
TargetsTranscription FactorsEnzymes
![Page 14: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/14.jpg)
Actin Microtubules Intermediatefilaments
Cytoskeletal Structures
Chapter 17
![Page 15: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/15.jpg)
Microtubules
Vesicle Transport
Chromosome segregation(mitotic spindle)
Cilia/Flagella
![Page 16: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/16.jpg)
Tubulin Dimer
GTP
GTP
![Page 17: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/17.jpg)
![Page 18: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/18.jpg)
GFP-Tagged Centrosomes
![Page 19: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/19.jpg)
Centrosome Structure
![Page 20: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/20.jpg)
![Page 21: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/21.jpg)
![Page 22: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/22.jpg)
TaxolColchicine
Pacific YewAutumn crocus
Microtubule “Poisons”
![Page 23: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/23.jpg)
![Page 24: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/24.jpg)
Tau Protein Stabilizes Microtubules in Neurons
![Page 25: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/25.jpg)
Tau Protein
![Page 26: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/26.jpg)
Tau “tangles”
Regulation of Microtubule Stability by Tau
![Page 27: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/27.jpg)
Alzheimer’s Brain
![Page 28: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/28.jpg)
Alzheimer’s Brain
![Page 29: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/29.jpg)
Tau Protein
![Page 30: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/30.jpg)
Microtubule “Motor” Proteins
![Page 31: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/31.jpg)
![Page 32: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/32.jpg)
Microtubule “Motor” Proteins
![Page 33: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/33.jpg)
GFP-Tagged Centrosomes
![Page 34: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/34.jpg)
Centrosome Duplication Cycle
![Page 35: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/35.jpg)
Ciliated Cells
![Page 36: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/36.jpg)
![Page 37: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/37.jpg)
Actin Filaments
![Page 38: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/38.jpg)
Actin Monomer
![Page 39: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/39.jpg)
![Page 40: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/40.jpg)
Arp2/3 (Actin Related Proteins)
Arp2
Arp3
![Page 41: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/41.jpg)
Gelsolin Protein
New minus end
New plus end
![Page 42: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/42.jpg)
Acton Poisons
![Page 43: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/43.jpg)
![Page 44: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/44.jpg)
Myosin-II
![Page 45: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/45.jpg)
Muscle Cell
![Page 46: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/46.jpg)
Sarcomere
![Page 47: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/47.jpg)
Contraction of a Sarcomere
![Page 48: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/48.jpg)
Resting Muscle
Rigor position
![Page 49: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/49.jpg)
Contraction of a Sarcomere
![Page 50: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/50.jpg)
Tropomyosin blocksaccess to actin filament
![Page 51: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/51.jpg)
Ca2+
Binds Troponin C
![Page 52: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/52.jpg)
![Page 53: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/53.jpg)
Muscle Cell
![Page 54: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/54.jpg)
![Page 55: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/55.jpg)
Muscle Relaxants
Pancuronium Baclofen
Ligand for Seven-pass receptorInhibits Ligand-gated ion channels
![Page 56: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/56.jpg)
Muscle Cell
![Page 57: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/57.jpg)
Muscle Cell
Pancuronium
Muscle cell membrane can not be de-polarized
![Page 58: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/58.jpg)
Baclofin
Muscle CellMembrane
Muscle CellMembrane
Muscle cell membrane can not be de-polarized
![Page 59: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/59.jpg)
![Page 60: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/60.jpg)
Muscular Dystrophy
Dystrophin gene (2.4 million bp, 78 exons)
X-linked Recessive
Progressive muscle weakness/loss of skeletal muscle
![Page 61: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/61.jpg)
Pg. 574
![Page 62: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/62.jpg)
Pg. 576
![Page 63: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/63.jpg)
Pg. 577
![Page 64: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/64.jpg)
Pg. 575
Keratin Filaments
![Page 65: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/65.jpg)
Desmosome
Pg. 715
![Page 66: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/66.jpg)
Pg. 577
![Page 67: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/67.jpg)
Epidermolysis Bullosa(Keratin mutations)
Pg. 577
![Page 68: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/68.jpg)
Epidermolysis Bullosa(Keratin mutations)
![Page 69: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/69.jpg)
Mitotic Cell Cycle
DNAReplication
![Page 70: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/70.jpg)
G1 S G2
G1
M-Phase
![Page 71: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/71.jpg)
![Page 72: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/72.jpg)
(G1 Phase)
(G2 Phase)
Semi-Conservative DNA Replication
![Page 73: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/73.jpg)
![Page 74: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/74.jpg)
Binding site forOrigin Recognition Complex (ORC)
(ORC)
![Page 75: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/75.jpg)
![Page 76: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/76.jpg)
![Page 77: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/77.jpg)
Completing Synthesis of the Lagging Strand
(5’ to 3” exonuclease)*
*
![Page 78: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/78.jpg)
Thymine Tautomers
Pairs with Adenine Pairs with Guanine
(common form) (rare form)
![Page 79: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/79.jpg)
DNA Polymerase “proof reading”
![Page 80: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/80.jpg)
End Replication Problem
Final RNA primers removed
Second round ofDNA replication
First round ofDNA replication
*
*
*
*
A
![Page 81: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/81.jpg)
Telomere Synthesis
![Page 82: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/82.jpg)
Telomerase RNA
156 nucleotides
![Page 83: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/83.jpg)
Telomere Synthesis
![Page 84: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/84.jpg)
Normal Cell Telomeres
Short Telomeres
Apoptosis
Chromosome Instabilty/DNA Damage
![Page 85: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/85.jpg)
![Page 86: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/86.jpg)
![Page 87: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/87.jpg)
Telomerase Inhibitor
Apoptosis
Telomostatin
~ 90 of all cancers haveRe-activated telomerase
![Page 88: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/88.jpg)
Mitotic Cell Cycle
DNAReplication
![Page 89: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/89.jpg)
G1 S G2
G1
M-Phase
![Page 90: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/90.jpg)
Cohesion of Sister Chromatids
Cohesin “ring”
![Page 91: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/91.jpg)
Nuclear Lamina
![Page 92: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/92.jpg)
Fig. 19-18 (replacement)
![Page 93: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/93.jpg)
Interphase and M-Phase Chromosomes
![Page 94: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/94.jpg)
Condensation of Chromatids
![Page 95: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/95.jpg)
Microtubules
![Page 96: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/96.jpg)
Centrosome Duplication Cycle
![Page 97: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/97.jpg)
Mitotic Spindle
![Page 98: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/98.jpg)
Pg. 641
Metaphase Anaphase
![Page 99: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/99.jpg)
Pg. 257
Ubiquitin-dependent Protein Degradation
Proteasome
Amino acids + Ub
Protein Ub-Ub-Ub
Protein + Ub
APC (Ubiquitin Ligase)
![Page 100: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/100.jpg)
Start of Anaphase
P
![Page 101: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/101.jpg)
Anaphase “A” and “B”
![Page 102: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/102.jpg)
Cytokinesis
![Page 103: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/103.jpg)
Myosin II - GFP
Interphase Telophase Cytokinesis
CytokinesisCytokinesis G1
![Page 104: Stem Cell Concept Pg. 721. Signal Transduction Pathways and Cell Differentiation Specialized cell type (neuron, skin cell, red blood cell, etc.) Stem](https://reader035.vdocument.in/reader035/viewer/2022062714/56649d375503460f94a0f9d1/html5/thumbnails/104.jpg)
“Contractile Unit” in Cytokinesis
Fig. 17-41
Plasma Membrane
Cytosol
Septin“ring”