stem cells & engineering
TRANSCRIPT
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What are Stem Cells?
They can divide and make identical copies of
themselves: Self-Renewal
Remain Unspecialized with no ‘specific’ function
Differentiate to produce over 200 different types ofcells in the body.
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The Major Types of Stem Cells
Embryonic Stem Cells
From blastocysts
B. Adult Stem Cells
blood, bone marrow, liver, kidney, cornea, dental
pulp, umbilical cord, brain, skin, muscle,salivary gland . . . .
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Cloning
• What is cloning?• Asexual reproduction
• Examples?• Bacteria, fungus• Plants – cutting – potato• Farm animals
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Removing the maternal nucleus beforenuclear transfer
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• 2002 – Rabbits cloned
2003 – Mule cloned
“CC” Carbon Copy
2004 – Bull serial-cloned 2005 – Dog cloned
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Countries Human Embryo Cloning
(=creating embryo)
Use of Stem Cell
Lines
Use of Superfluous
Embryos
France, Spain Prohibited Authorized Authorized
Italy, Austria, Ireland Prohibited Prohibited Prohibited
U.K. Denmark Authorized Authorized Authorized
Israel, Sweden,Belgium, India
Prohibited Authorized Authorized
Germany Prohibited Authorized
(imported)
Authorized
U.S.A. Prohibited (public)
Free (private)
Authorized under
restricted condition(public)
Free (private)
Authorized
(in most states)
Canada Prohibited Under consideration Under consideration
Japan, Netherlands,Korea
Authorized Authorized Authorized
Australia Currently prohibitedbut underconsideration
Authorized Authorized
Summary of Policies Defined Around the World
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Cancer Stem Cells
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Cancer Stem Cells
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Why Make Recombinant DNA?
• Cure or treat disease
• Genetically modify our foods to increase
flavor, yield, nutritional value or shelf-life
• Better understand human genetics
• Clone cells or organs
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Recombinant DNA
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Recombinant DNA
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Cell SourceEmbryonic stem cells
Adult stem cells
Progenitor cells
SignalsGrowth factors
DrugsMechanical forces
ECMMetals
CeramicsSynthetic polymersNatural polymers
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A 3D calcium phosphate scaffold
From Becton Dickinson
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