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Stephen J Moss Education 1989, Ph.D. Imperial College, University of London, U.K. in Molecular Neurobiology. 1984, B.Sc (Hons). University of Bath, U.K. in Biochemistry. Current Position The Sackler Family Professor of Neuroscience, June 2008-present. Director of the Astrazeneca-Tufts Laboratory of Basic and Translational Neuroscience. Address: Tufts Neuroscience – 605 South Cove, 136 Harrison Ave, Boston, MA 02111 Phone: 617-636-3896, and Director of the AstraZeneca/Tufts Lab of Translational Neuroscience. Email: Stephen.Moss@tufts.edu, Website: http://www.neurosci.tufts.edu/faculty_labs/moss/moss.html. Adjunct Appointments 2003-present, Professor of Molecular Pharmacology and Cell Biology, Department of Pharmacology, University College, Gower Street London WC1E 6BT. 2012-2016 Standing member of the NINDS study sections SYN/NTRC. Consultancies 2012-present, Advisory board member for AstraZeneca Neuroscience. 2011-present, Advisory board member and Consultant to Sage Therapeutics. 2010-2011, Consultant, TASAP, Pfizer. 2005-2010, Consultant, Sepracor Pharmaceuticals. 2002-2010, Member of Scientific Advisory Board, Wyeth Pharmaceuticals. 1998-2005, Member of the Scientific Advisory Board for the Neurology CEDD, GlaxoSmithKline. Editorial Positions 2001-present, Editor of Neuropharmacology. 2008-present, Editor of Amino acids. 2011-2016, Editor of The Journal of Biological Chemistry. 2012-present, Editor Frontiers in Physiology. 2015-present, Editor of Frontiers in Molecular Neuroscience. Professional History 2003-2008, Professor of Neuroscience, University of Pennsylvania. 2000-2003, Professor of Molecular Pharmacology, MRC Laboratory of Molecular Cell Biology, University College London, U.K. 1997-2000, Reader in Pharmacology and Cell Biology, MRC Laboratory of Molecular Cell Biology, University College London, U.K. 1994-1997, Senior Fellow, MRC Laboratory of Molecular Cell Biology, and Department of Pharmacology University College London, U.K. 1992-1993, Postdoctoral Research Assistant, Department of Biology, University College London, U.K. 1989-1992, Howard Hughes Research Associate, Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, U.S.A. 1988-1989, Postdoctoral Research Fellow, Mammalian Cell Expression Group, British Biotechnology Ltd, Oxford, U.K. 1984-1987, Ph.D. Student, MRC Unit of Neurobiology, Cambridge University and G.D. Searle & Co., High Wycombe, U.K. Active Grants 2006-2017. NIH-NINDS, R01 NS051195; Constructing inhibitory synapses, role PI. Direct costs; $285,000/yr. 2012-2017. NIH-NINDS, R01 NS081986: GABAergic regulation of glutamine synthetase and its role in preventing epilepsy, role PI. Direct costs; $225,000/yr.

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2013-2022. NIH-NIMH, R01 MH097446: Novel actions of neurosteroids on GABAAR trafficking, Co-PI. Direct costs; $255,000/yr. 2012-2018. SAGE Therapeutics: Developing new GABAAR allosteric modulators, role PI. Direct costs; $150,000/yr. 2013-2020. AstraZeneca; IMED/GABABR drug development; role; PI. Direct costs; $950,000/yr 2014-2018. NIH-NIDA, DA037170-01: Dissecting Mechanisms of GABAB-GIRK Plasticity with Psychostimulants, role Co-PI. Direct cost; $105,000/yr 2014-2019. NIH-NINDS, 1R01NS087662: Deficits in KCC2 activity and the pathophysiology of Status Epilepticus, role; PI. Direct cost; $240,000/yr. 2016-2017. DOD, AR140209: Neurosteroids reverse tonic inhibition deficits in Fragile X syndrome, role Co-PI. Direct cost; $80,000/yr. 2015-2017. NIH-NIMH, 1R21MH106954: Deficits in KCC2 activity and the pathophysiology of autism spectrum disorders, role; PI. Direct cost; $120,000/yr. 2017-2022. NIH-NINDS 1R01NS101888: Modulation of KCC2 activity and the postnatal development of synaptic inhibition, role; PI. Direct costs; $2920,000/yr

Trainees

Name Position Training years

Current position

Abramian, Matthew Graduate Student 2007-2012

Postdoctoral Fellow, Department of Neurology, Stanford University.

Arancibia, Lorena Graduate Student/Postdoc

2001-2007

Postdoctoral Fellow, University College London, London, UK

Armstrong-Gold, Cecilia

Research Associate 2005-2007

Homemaker, Philadelphia, Pa

Fiona Bedford Postdoc 1996-2001

Assistant Professor, McGill University, Canada

Bogdanov, Yury Research Associate 2001-2006

Assistant Professor, University of Southampton UK

Brandon, Nick Graduate Student/ Posdoc

1995-1999

Chief Scientist, Neuroscience, AstraZeneca, Boston.

Charles, Kelly Graduate Student 1999-2002

Head of Communications AstraZeneca, Alderely Edge, UK

Comenencia Ortiz, Eydith

Graduate Student 2009-2012

Scientific Officer, Biogen, Boston, Ma

Cho, Chang Hoon Postdoc 2007-2008

Postdoc Children’s Hospital, Philadelphia, Pa

Connolly, Christopher

Postdoc 1994-2001

Professor of Neuroscience, University of Dundee, UK

Couve, Andrés Postdoc 1998-2002

Professor, University of Santiago, Chile

Dumoulin, Andrea Postdoc 2000- Instructor, École Normale Supérieure, Paris,

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2002 France

Fairfax, Ben Graduate Student 1999-2003

Assistant Professor, University of Oxford, UK

George Gorrie Graduate Student 1994-1997

Consultant Neurologist, Glasgow NHS trust, UK

Hanley, Jon Graduate Student/ Posdoc

1995-1998

Professor of Neuroscience, Bristol University, UK

Helene, Marie Graduate Student 1997-2001

Professor, European Brain Institute, Rome, Italy

Hines Rochelle Posdoc 2009-2015

Assistant Professor, University of Nevada, Las Vegas

Jacob, Tija Research Associate 2002-2011

Assistant Professor, University of Pittsburgh, Pa

Jovanovic, Jasmina Postdoc 1999-2003

Associate Professor, The London School of Pharmacy, UK

Jurd, Rachel Research Associate 2007-2010

Editor of Trends in Neuroscience, Boston, Ma

Kittler, Joseph Graduate Student/ Posdoc

1997-2001

Professor of Neuroscience, University College London, UK

Ji-Yong-Kang Postdoc 2013-2016

Consultant, Accenture, Philadelphia, PA.

Kretschmannova, Karla

Research Associate 2008-2012

Instructor Harvard University, Boston, Ma

Kuramoto, Nobuyuki Postdoc 2002-2006

Associate Professor, Setsunan University, Japan

Lee, Hing Cheong (Henry)

Graduate Student/Posdoc

2003-2010

Postdoc, Children’s Hospital, Boston, MA.

Macdonald, Bernard Graduate Student/Postdoc

1994-2000

Patent Lawyer, London.

McAinsh, Kristina Graduate Student 2000-2006

Postdoctoral Fellow, University of Cambridge, UK

Michels, Guido Postdoc 2005-2007

Professor of Internal Medicine, University of Koln, Germany

Morgan Richard Postdoc 1999-2001

Professor, St Georges Medical School, London, UK

Michelanne Munoz Postdoc 2013-2015

Postdoctoral fellow, Johnson and Johnson, San Diego

Popiolek, Michael Graduate Student 2007-2010

Senior Scientist, Pfizer, Boston, Ma

Rathenberg, Jan Postdoc 2000-2002

Principle Scientist, Max-Planck Institute, Munich, Germany

Restituito, Sophie Postdoc 1999-2004

Assistant Professor, NYU Langone Medical Center, NY

Revilla-Sanchez, Raque

Research Associate 2001-2011

Founder RSR Technologies, Barcelona, Spain

Saliba, Richard Research Associate 2002-2011

Scientific Journalist, London, UK

Sukoff Rizzo, Stacey Graduate Student 2008-2012

Principle Scientist, Pfizer, Boston, Ma

Liliya, Silayeva Graduate Student 2010-2015

Principle Scientist, Aberdeen Proving ground MA.

Taylor, Pamela Graduate Student 1994-1998

Patent Layer, J A Kemp and Co, London, UK

Terumuna, Miho Research Assistant 2005- Professor of Densitry, Niigata University, Japan

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2015

Tretter, Verena Research Associate 2000-2007

Assistant Professor, University of Vienna, Austria

Vien, Thuy Graduate Student 2012-2016

Postdoctoral fellow, Department of Pharmacology, Northwestern University, Chicago.

Vithlani, Mansi Graduate Student/ Posdoc

2003-2010

Postdoc, Royal Free Hospital London UK.

Wan, Qin Postdoc 2007-2009

Staff Scientist, NEI, NIH, Washington DC

Wiseman, Shari Postdoc 2014-2016

Editor, Nature Neuroscience, New York.

Nakamura, Yasuko Postdoc 2010-2016

Research Associate, University of Bristol, UK.

Current Trainees

Name Position Training years

Davies, Paul Research Assistant Professor

2007-

Deeb, Tarek Research Assistant Professor

2010-

Huyghe, Deborah

Postdoc 2010-

Modgil, Amit Postdoc 2012-

Yvonne Moore

Graduate student 2013

Ross Cardarelli

Postdoc 2013-

Chadchankar, Jayashree

Postdoc 2014-

Heiki Wobst Postdoc 2014-

Parakala, Manasa

Graduate Student 2014

Mathew Kelly Graduate Student 2014-

Jay Murkerjee

Postdoc 2014-

Lesley Conway

Postdoc 2014-

Nathanson, Anna

Graduate student 2015-

Sodhi, Puneet

Postdoc 2015-

Frank, Pernille

Visiting Graduate student (University of Copenhagen)

2016-

Renoux, Abigail

Postdoc 2016-

Chadchankar, Haremb

Postdoc 2016-

Denninger, Andrew

Postdoc 2016-

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Publications Peer-reviewed articles 1. Karni, L., Moss, S.J. and Tel-Or, E. (1984). Glutathione reductase activity in hetrocysts and vegetative cells of the cyanobacterium Nostoc Moscorum. Archives of Microbiology, 140: 215 - 217. 2. Moss, S.J. and Wonnacott, S. Nicotinic facilitation of acetylcholine release in hippocampal synaptosomes (1985). Biochem. Soc. Trans, 13:164 69-72. 3. Van Renterghem, C., Bilbe, G., Moss, S., Smart, T.G., Constanti, A., Brown, D.A. and Barnard, E.A. (1987). GABA receptors induced in Xenopus oocytes by chick brain mRNA: evaluation of TBPS as a use-dependent channel-blocker. Brain Res., 388: 21-31. 4. Barnard, E.A., Bilbe, G., Houamed, K., Moss, S.J., Van Renterghem, C. and Smart, T.G. (1987) Functional expression in the Xenopus oocyte of messenger ribonucleic acids encoding brain neurotransmitter receptors: further characterisation of the implanted GABA receptor. Neuropharmacol., 26: 837-44. 5. Moss, S.J., Beeson, D.M., Jackson, J.F., Darlison, M.G. and Barnard, E.A. (1987). Differential expression of nicotinic acetylcholine receptor genes in innervated and denervated chicken muscle. EMBO J. 6: 3917-21. 6. Moss, S.J., Darlison, M.G., Beeson, D.M. and Barnard, E.A. (1989). Developmental expression and quantification of mRNA levels of the subunits of the acetylcholine receptor from chicken muscle. J. Biol. Chem. 264: 20199-205. 7. Barnard, E.A., Darlinson, M.G., Harvey, R., Marshall, J., Moss, S.J., Sattelle, D.B., Smart, T.G. and Vreugdenhil, E. (1990). Cloned genes for ligand-operated ion channels and their expression in vitro. Adv. Second. Messenger Phosphoprotein Res. 24: 20-9. 8. Moss, S.J., Smart, T.G., Porter, N.M., Nayeem, M., Devine, J., Stephenson, F.A., Macdonald, R.L. and Barnard, E.A. (1990). Cloned GABA receptors are maintained in a stable cell line: allosteric and channel properties. Eur. J. Pharmacol. 189: 77-88. 9. Moss, S.J., Ravindran, A., Mei, L., Wang, J.B., Kofuji, P., Huganir, R.L. and Burt, D.R. (1991). Characterization of recombinant GABAA receptors produced from murine α1, β1 and γ2 subunit cDNAs.

Neurosci. Lett. 123: 265-8. 10. Kofuji, P., Wang, J.B., Moss, S.J., Huganir R.L. and Burt, D.R. (1991). Generation of two forms of the gamma-aminobutyric acid A receptor γ2 subunit in mice by alternative splicing. J. Neurochem. 56: 713-5. 11. Smart, T.G., Moss, S.J., Xie, X. and Huganir R.L. (1991). GABAA receptors are differentially sensitive to

zinc: dependence on subunit composition. Br. J. Pharmacol 103: 1837-9. 12. Moss, S.J., Harkness, P.C., Mason, I.J., Barnard, E.A. and Mudge, A.W. (1991). Evidence that CGRP and cAMP increase transcription of the AChR α subunit gene, but not of other subunit genes. J. Mol. Neurosci. 3: 101-8. 13. Blackstone, C.D., Moss, S.J., Martin, L.J., Levey, A.I., Price, D.L. and Huganir R.L. (1992). Biochemical characterization and localization of a non-N-methyl-D-aspartate glutamate receptor in rat brain. J. Neurochem. 58: 1118-26. 14. Swope, S.L., Moss, S.J., Blackstone, C.D. and Huganir, R.L. (1992). Phosphorylation of ligand-gated ion channels: a possible mode of synaptic plasticity. FASEB J. 6: 2514-23. 15. Wang, J.B., Kofuji, P., Fernando, J.C., Moss, S.J., Huganir, R.L. and Burt, D.R. (1992). The α1, α2 and α3 subunits of GABAA receptors: comparison in seizure-prone and -resistant mice and during development. J.

Mol. Neurosci. 3: 177-84. 16. Moss, S.J., Doherty, C.A. and Huganir R.L. (1992). Identification of the cAMP-dependent protein kinase A and protein kinase C phosphorylation sites within the major intracellular domains of the β1γ2S and γ2L subunits of the γ-aminobutyric acid type A receptor. J. Biol. Chem. 267: 14470-6. 17. Moss, S.J., Smart, T.G., Blackstone, C.D. and Huganir R.L. (1992). Functional modulation of GABAA receptors by cAMP-dependent protein phosphorylation. Science 257: 661-5. 18. Moss, S.J., Blackstone, C.D. and Huganir R.L. (1993). Phosphorylation of recombinant non-NMDA glutamate receptors on serine and tyrosine residues. Neurochem. Res. 18: 105-10. 19. Krishek, B.J., Xie, X., Blackstone, C., Huganir, R.L. Moss, S.J. and Smart T.G. (1994). Regulation of GABAA receptor function by protein kinase C phosphorylation. Neuron 12: 1081-95.

20. McDonald, B.J. and Moss S.J. (1994). Differential phosphorylation of intracellular domains of -dependent protein kinase and

cGMP-dependent protein kinase. J. Biol Chem 269: 18111-7.

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21. Blackstone, C., Murphy, T.H., Moss, S.J., Baraban, J.M. and Huganir R.L. (1994). Cyclic AMP and synaptic activity-dependent phosphorylation of AMPA-preferring glutamate receptors. J. Neurosci. 14(12): 7585-93. 22. Moss, S.J., Gorrie, G.H., Amato, A. and Smart T.G. (1995). Modulation of GABAA receptors by tyrosine

phosphorylation. Nature 377: 344-8. 23. Valenzuela, C.F., Kazlauskas, A., Brozowski, S.I., Weiner, J.L., Demali, K.A., McDonald, B.J., Moss, S.J., Dunwiddie, T.V. and Harris R.A. (1995). Platelet-derived growth factor receptor is a novel modulator of

-gated ion channels. Mol. Pharmacol 48: 1099-107. 24. Moss, S.J. and Smart, T.G. (1996). Modulation of amino acid-gated ion channels by protein phosphorylation. Int. Rev. Neurobiol. 39: 1-52. 25. Connolly, C.N., Krishek, B.J., McDonald, B.J., Smart, T.G. and Moss, S.J. (1996). Assembly and cell surface expression of heteromeric and homomeric γ-aminobutyric acid type A receptors. J. Biol. Chem. 271: 89-96. 26. Krishek, B.J., Amato, A., Connolly, C.N., Moss, S.J. and Smart T.G. (1996). Proton sensitivity of the GABAA receptor is associated with the receptor subunit composition. J. Physiol. 492: 431-43.

27. Krishek, B.J., Moss, S.J. and Smart T.G. (1996). Homomeric β1 γ-aminobutyric acid A receptor-ion channels: evaluation of pharmacological properties and physiological properties. Mol. Pharmacol. 49: 494-504. 28. Connolly, C.N., Wooltorton, J.R., Smart, T.G. and Moss, S.J. (1996). Subcellular localization of γ receptor β subunits. Proc. Natl. Acad. Sci. (USA) 93: 9899-904. 29. Moss, S.J. and Smart T.G. (1996). Modulation of amino acid-gated ion channels by protein phosphorylation. Int. Rev. Neurosci. 39: 1-52. 30. Eugene, D., Moss, S.J., and Smart T.G. (1996). Thiocyanate ions inhibit AMPA-activated currents in recombinant non-NMDA receptors expressed in Xenopus laevis oocytes: the role of the GluR2 subunit. Eur. J. Neurosci. 8: 1983-93. 31. Moss, S.J., McDonald, B.J., Rudhard, Y. and Schoepfer, R. (1996). Phosphorylation of the predicted major intracellular domains of the rat and chick neuronal nicotinic acetylcholine receptor α7 subunit by cAMP-dependent protein kinase. Neuropharmacology 35: 1023-8. 32. Krishek, B.J., Moss, S.J. and Smart T.G. (1996). A functional comparison of the antagonists bicuculline and picrotoxin at recombinant GABAA receptors. Neuropharmacology 35: 1289-98.

33. McDonald, B.J. and Moss S.J. (1997). Conserved phosphorylation of the intracellular domains of GABAA receptor β2 and β3 subunits by cAMP-dependent protein kinase, cGMP-dependent protein kinase,

protein kinase C and Ca2+/calmodulin type II-dependent protein kinase. Neuropharmacology 36: 1377-85. 34. Sivilotti, L., Okuse, K., Akopian, A.N., Moss, S. and Wood J.N. (1997). A single serine residue confers tetrodotoxin insensitivity on the rat sensory-neuron-specific sodium channel SNS. FEBS Lett. 409: 49-52. 35. Gorrie, G.H., Vallis, Y., Stephenson, A., Whitfield, J., Browning, B., Smart, T.G. and Moss, S.J. (1997). Assembly of GABAA receptors composed of α1 and β2 subunits in both cultured neurons and fibroblasts. J.

Neurosci. 17: 6587-96. 36. Wisden W. and Moss S.J. (1997). GABAA subunit assembly and sorting: gene targeting and cell biology

approaches. Biochem. Soc. Trans. 25: 820-4. 37. Wooltorton, J.R., McDonald, B.J., Moss, S.J. and Smart T.G. (1997). Identification of a Zn2+ binding site on the murine GABAA receptor complex: dependence on the second transmembrane domain of β subunits. J.

Physiol. 505(3): 633-40. 38. Wooltorton, J.R., Moss, S.J. and Smart, T.G. (1997). Pharmacological and physiological characterization of murine homomeric β3 GABAA receptors. Eur. J. Neurosci. 9: 2225-35. 39. Krishek, B.J., Moss, S.J. and Smart T.G. (1998). Interaction of H+ and Zn2+ on recombinant and native rat neuronal GABAA receptors. J. Physiol. 507: 639-52. 40. McDonald, B.J., Amato, A., Connolly, C.N., Benke D., Moss, S.J. and Smart T. G. (1998). Adjacent phosphorylation sites on GABAA receptor β subunits determine regulation by cAMP-dependent protein kinase.

Nat. Neurosci 1: 23-8. 41. Couve, A., Filippov, A.K., Connolly, C.N., Bettler, B., Brown, D.A. and Moss S.J. (1998). Intracellular retention of recombinant GABAB receptors. J. Biol Chem. 273: 26361-7.

42. Chen, A.C., McDonald B., Moss, S.J. and Gurling, H.M. (1998). Gene expression studies of mRNAs encoding the NMDA receptor subunits NMDAR1, NMDAR2A, NMDAR2B, NMDAR2C, and NMDAR2D

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following long-term treatment with cis-and trans-flupenthixol as a model for understanding the mode of action of schizophrenia drug treatment. Brain Res. Mol. Brain Res. 54(1): 92-100. 43. Dunne, E., Moss, S.J. and Smart, T.G. (1998). Inhibition of GABAA receptor function by tyrosine kinase inhibitors and their inactive analogues. Mol. Cell Neurosci. 12: 300-10. 44. Swope, S.L., Moss, S.J., Raymond, L.A. and Huganir, R.L. (1999). Regulation of ligand-gated ion channels by protein phosphorylation. Adv. Second Messenger Phosphoprotein Res. 33: 49-78. 45. Amato, A., Connolly, C.N., Moss, S.J. and Smart, T.G. (1999). Modulation of neuronal and recombinant GABAA receptors by redox reagents. J. Physiol. 517: 35-50.

46. Fitzgerald, E.M., Okuse, K., Wood, J.N., Dolphin, A.C. and Moss, S.J. (1999). cAMP-dependent phosphorylation of the tetrodotoxin-resistant voltage-dependent sodium channel SNS. J. Physiol. 516(2): 433-446. 47. Hanley, J.G., Koulen, P., Bedford, F.K, Gordon-Weeks, P.R. and Moss, S.J. (1999) The protein MAP-1B links GABAC receptors to the cytoskeleton at retinal synapses. Nature 397: 66-9. 48. Wang, H.W., Bedford, F.K., Brandon, N.J., Moss, S.J. and Olsen R.W. (1999). GABAA-receptor-associated protein link GABAA receptors and the cytoskeleton. Nature 397: 69-72.

49. Patel, R., Holt, M., Philipova, R., Moss, S., Schulman, H., Hidaka, H. and Whitaker M. (1999). Calcium/calmodulin-dependent phosphorylation and activation of human Cdc25-C at the G2/M phase transition in HeLa cells. J. Biol. Chem. 274: 7958-68. 50. Connolly, C.N., Uren, J.M., Thomas, P., Gorrie, G.H., Gibson, A., Smart, T.G. and Moss, S.J. (1999). Subcellular localization and endocytosis of homomeric γ2 subunit splice variants of γ-aminobutyric acid type A receptors. Mol. Cell Neurosci. 13(4): 259-71. 51. Forbes, L.V., Moss, S.J. and Segal A.W. (1999). Phosphorylation of p67phox in the neutrophil occurs in the cytosol and is independent of p47phox. FEBS Lett. 449: 225-9. 52. Forbes, L.V., Troung, O., Wientjes, F.B., Moss, S.J. and Segal A.W. (1999). The major phosphorylation site of the NADPH oxidase complex p67phox is Thr233. Biochem J. 338: 99-105. 53. Taylor, P.M., Thomas P., Gorrie, G.H., Connolly, C.N., Smart, T.G. and Moss S.J. (1999). Identification of amino acid residues within GABAA receptor β subunits that mediate both homomeric and heteromeric receptor expression. J. Neurosci. 19: 6360-71. 54. Brandon, N.J, Bedford, F.K., Connolly, C.N., Couve, A., Kittler, J.T., Hanley, J.G., Jovanovic, J.N., Uren, J., Taylor, P., Thomas, P., Smart T.G. and S. J. Moss (1999). Synaptic targeting and regulation of GABAA receptors. Biochem. Soc. Trans. 27: 527-30. 55. Brandon, N.J., Uren, J.M., Kittler, J.T., Wang, H., Olsen, R., Parker, P.J. and Moss, S.J. (1999). Subunit-specific association of protein kinase C and the receptor for activated C kinase with GABA type A receptors. J. Neurosci. 19: 9228-34. 56. Connolly, C.N., Kittler, J.T., Thomas, P., Uren, J.M., Brandon, N.J., Smart, T.G. and Moss, S.J. (1999). Cell surface stability of γ-aminobutyric acid type A receptors: Dependence on protein kinase C activity and subunit composition. J. Biol. Chem 274: 36565-72. 57. Brandon, N.J. and Moss, S.J. (2000). Receptor cross talk: ligand-gated ion channels start to communicate. Sci. STKE 2000(55): PE1. 58. Hanley, J.G., Jones, E.M. and Moss S.J. (2000). GABA receptors rho1 subunit interacts with a novel splice variant of the glycine transporter, GLYT-1. J. Biol. Chem. 275: 840-6. 59. Billups, D., Hanley, J.G., Orme, M., Attwell, D. and Moss.S.J. (2000). GABAC receptor sensitivity is modulated by interaction with MAP1B. J. Neurosci. 20: 8643-50. 60. Taylor, P.M., Connolly, C.N, Kittler, J.T., Gorrie, G.H., Hosie, A., Smart, T.G. and Moss S.J (2000). Identification of residues with GABAA receptor α subunits that mediate specific assembly with receptor β subunits. J. Neurosci. 20: 1297-306. 61. Flores-Hernandez, J., Hernandez, S., Snyder, G.L., Yan, Z., Fienberg, A.A., Moss, S.J., Greengard, P. and Surmeier, J. (2000). D1 dopamine receptor activation reduces GABAA receptor currents in neostriatal neurons through a PKA/DARPP-32/PP1 signaling cascade. J. Neurophysiol. 83: 2996-3004. 62. Brandon, N.J., Delmas, P., Kittler, J.T., McDonald, B.J., Sieghart, W., Brown, D.A., Smart T.G. and Moss, S.J. (2000). GABAA receptor phosphorylation and functional modulation in cortical neurons by a protein kinase C-dependent pathway. J. Biol. Chem. 275: 38856-62. 63. Calver, A.R., Medhurst, A.D., Robbins, M.J., Charles, K.J., Evans, M.L., Harrison, D.C., Stammers, M., Hughes, S.A., Hervieu, G., Couve, A., Moss, S.J., Middlemiss, D.N. and Pangalos, M.N. (2000). The

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expression of GABAB1 receptor subunits in the CNS differs from that in peripheral tissues. Neuroscience 100(1): 155-70. 64. Kittler, J.T., Delmas P., Jovanovic, J.N., Brown, D.A., Smart, T.G. and Moss S.J. (2000). Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J. Neurosci. 20: 7972-7. 65. Couve, A., Moss, S.J. and Pangalos, M.N. (2000). GABAB receptors: a new paradigm in G protein signaling. Mol. Cell. Neurosci. 16: 296-312. 66. Kittler, J.T., Wang, J., Connolly, C.N., Vicini, S., Smart, T.G. and Moss S.J. (2000). Analysis of GABAA receptor assembly in mammalian cell lines and hippocampal neurons using γ2 subunit green fluorescent protein chimeras. Mol. Cell. Neurosci. 16: 440-52. 67. Filippova, A.K., Couve, A., Pangalos, M.N., Walsh, F.S., Brown, D.A., and Moss S.J. (2000). Heteromeric assembly of GABAB R1 and R2 receptor subunits inhibits Ca2+ current in sympathetic neurons. J. Neurosci. 20: 2867-74. 68. Calver, A.R, Robbins, M.J., Cosio, C., Rice, S.Q. Babbs, A.J., Hirst, W.D., Boyfield, I., Wood, M.D., Russell, R.B., Price, G.W., Couve, A., Moss, S.J. and Pangalos M.N. (2001). The C-terminal domains of the GABAB receptor subunits mediate intracellular trafficking but are not required for receptor signaling. J. Neurosci. 21: 1203-10. 69. Couve, A., Kittler, J.T., Uren, J.M., Calver, A.R., Pangalos, M.N., Walsh, F.S. and Moss, S.J. (2001) Association of GABAB receptors and members of the 14-3-3 family of signaling proteins. Mol. Cell. Neurosci.

17(2): 317-28. 70. Moss, S.J. and Smart, T.G. (2001). Constructing inhibitory synapses. Nat. Rev. Neurosci. 2: 240-50. 71. Kittler, J.T. and Moss, S.J. (2001). Neurotransmitter receptor trafficking and the regulation of synaptic strength. Traffic 2: 437-48. 72. Kittler, J.T., Rostaing, P., Schiavo, G., Fritschy, J.M., Olsen, R., Triller, A. and Moss S.J. (2001). The subcellular distribution of GABARAP and its ability to interact with NSF suggest a role for this protein in the intracellular transport of GABAA receptors. Mol. Cell. Neurosci. 18: 13-25. 73. Bedford, F.K., Kittler, J.T., Muller, E., Thomas, P., Uren, J.M., Merlo, D., Wisden, W., Triller, A., Smart, T.G. and Moss S.J. (2001). GABAA receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1. Nat. Neurosci. 4: 908-16. 74. Robbins, M.J., Calver, A.R., Filippov, A.K., Hirst, W.D., Russell, R.B., Wood, M.D., Nasir, S., Couve, A., Brown, D.A., Moss, S.J. and Pangalos, M.N. (2001). GABAB2 is essential for G-protein coupling of the GABAB receptor heterodimer. J. Neurosci. 21: 8043-52. 75. Brandon, N.J., Delmas, P., Hill, J., Smart, T.G. and Moss, S.J. (2001). Constitutive tyrosine phosphorylation of the GABAA Neuropharmacology 41: 745-52. 76. Brandon, N., Jovanovic, J. and Moss S. (2002). Multiple roles of protein kinases in the modulation of GABAA receptor function and cell surface expression. Pharmacol. Ther. 94: 113-22. 77. Knight, D., Harris, R., McAlister, M., Phelan, J.P., Geddes, S., Moss, S.J., Driscoll, P.C. and Keep, N.H. (2002). The X-ray crystal structure and putative ligand-derived peptide-binding properties of gamma-aminobutyric acid receptor type A receptor-associated protein. J. Biol. Chem. 277: 5556-61. 78. Marie, H., Billups, D., Bedford, F.K., Dumoulin, A., Goyal, R.K., Longmore, G.D., Moss, S.J. and Attwell, D. (2002). The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba. Mol. Cell. Neurosci. 19: 152-64. 79. Nymann-Andersen, J., Wang, H., Chen, L., Kittler, J.T., Moss, S.J. and Olsen, R.W. (2002) Subunit specificity and interaction domain between GABAA receptor-associated protein (GABARAP) and GABAA receptors J. Neurochem. 80: 815-23. 80. Kittler, J.T., McAinsh, K. and Moss S.J. (2002). Mechanisms of GABAA receptor assembly and trafficking: implications for the modulation of neurotransmission. Mol. Neurobiol. 26: 251-68. 81. Couve, A., Thomas, P., Hirst, W., Calver, A.R., Pangalos, M.N. Walsh, F.S., Smart, T.G. and Moss, S.J. (2002). Cyclic AMP-dependent protein kinase phosphorylation facilitates GABAB receptor-effector coupling. Nat. Neurosci. 5: 415-24. 82. Brandon, N.J., Jovanovic, J., Smart, T.G. and Moss, S.J. (2002). Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABAA receptors with the activation of G-protein-coupled receptors. J. Neurosci. 22 6353-61.

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83. Dunne, E.L., Hosie, A.M., Wooltorton, J.R., Duguid, I.C., Harvey, K., Moss, S.J., Harvey, R.J., Smart, T.G. (2002). An N-terminal histidine regulates Zn2+ inhibition on the murine GABAA receptor β3 subunit. Br. J. Pharmacol. 137: 29-38. 84. Bond, B.C., Virley, D.J., Cairns, N.J., Hunter, A.J., Moore, G.B., Moss, S.J., Mudge A.W., Walsh, F.S., Jazin, E. and Preece P. (2002). The quantification of gene expression in an animal model of brain ischaemia using TaqMan real-time RT-PCR. Brain Res. Mol. Brain Res. 106(1-2): 101-16. 85. Preece, P., Virley, D.J., Costandi, M., Coombes, R., Moss, S.J., Mudge, A.W., Jazin, E., and Cairns N.J. (2003). Beta-secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease. Brain Res Mol Brain Res. 116(1-2): 155-8. 86. Preece, P., Virley, D.J., Costandi, M., Coombes, R., Moss, S.J., Mudge, A.W., Jazin E. and Cairns, N.J. (2003). An optimistic view for quantifying mRNA in post-mortem human brain. Brain Res Mol Brain Res. 19: 7-16. 87. Marie, H., Pratt, S.J., Betson, M., Epple, H., Kittler, J.T., Meek, L., Moss, S.J., Troyanovsky, S., Attwell, D., Longmore, G.D. and Braga, V.M. (2003). The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin. J. Biol. Chem. 278(2):1220-8. 88. Bollan K., King, D., Robertson, L.A., Brown, K., Taylor, P.M., Moss, S.J. and Connolly, C.N. (2003). GABAA receptor composition is determined by distinct assembly signals within alpha and beta subunits. J. Biol. Chem. 278: 4747-55. 89. Brandon, N.J., Jovanovic, J.N., Colledge, M., Kittler, J.T., Scott, J.D. and Moss, S.J. (2003). A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABAA receptors by cAMP-dependent protein kinase via selective interaction with receptor β subunits. Mol. Cell. Neurosci. 22: 87-97. 90. Kittler, J.T. and Moss, S.J. (2003). Modulation of GABAA receptor activity by phosphorylation and receptor trafficking: implications for the efficacy of synaptic inhibition. Curr. Opin. Neurobiol. 13(3): 341-7. 91. Fairfax, B.P., Pitcher, J.A., Scott, M.G., Calver, A.R., Pangalos, M.N., Moss, S.J. and Couve A. (2004). Phosphorylation and chronic agonist treatment atypically modulate GABAB receptor cell surface stability. J. Biol. Chem. 279: 12565-73. 92. Preece, P., Virley, D.J., Costandi, M., Coombers, R., Moss, S.J., Mudge, A.W., Jazin, E. and Cairns, N.J. (2004) Amyloid precursor protein mRNA levels in Alzheimer’s disease brain. Brain Res. Mol. Brain Res. 122: 1-9. 93. Couve, C., Restituito, S., Brandon, J.M., Charles, K.J., Bawagan, H., Freeman, K.B., Pangalos, M.N., Calver, A.R., and Moss S.J. (2004). Marlin-1, a novel RNA-binding protein associates with GABA receptors. J. Biol. Chem. 279: 13934–43. 94. Jovanovic, J.N., Thomas, P., Kittler, J.T., Smart, T.G. and Moss S.J. (2004). Brain-derived neurotrophic factor modulates fast synaptic inhibition by regulating GABAA receptor phosphorylation, activity, and cell-surface stability. J. Neurosci. 24: 522-30. 95. Rathenberg, J., Kittler, J.T. and Moss S.J. Palmitoylation regulates the clustering and cell surface stability of GABAA receptors (2004). Mol. Cell. Neurosci. 26: 251-7. 96. Terunuma, M., Jang, I.S., Ha, S.H., Kittler, J.T., Kanematsu, T., Jovanovic, J.N., Nakayama, K.I., Akaike, N., Ryu, S.H., Moss S.J. and Hirata, M. (2004). GABAA receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein. J. Neurosci. 24: 7074-84. 97. Kittler, J.T., Thomas, P., Tretter, V., Bogdanov, Y., Haucke, V., Smart, T.G. and Moss S.J. (2004). Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating gamma-aminobutyric acid type A receptor membrane trafficking. Proc. Natl. Acad. Sci. USA 101: 12736-41. 98. Couve, A., Calver, A.R., Fairfax, B., Moss, S.J. and Pangalos M.N. (2004). Unravelling the unusual signalling properties of the GABAB receptor. Biochem. Pharmacol. 68 1527-36. 99. Kittler, J.T., Arancibia-Carcamo, I.L. and Moss S.J. (2004). Association of GRIP1 with a GABAA

receptor associated protein suggests a role for GRIP1 at inhibitory synapses. Biochem. Pharmacol. 68: 1649-1655. 100. Thuault, S.J., Brown, J.T., Sheardown, S.A, Jourdain, S., Fairfax, B., Spencer, J.P., Restituito, S., Nation, J.H., Topps, S., Medhurst. A.D., Randall, A.D., Couve, A., Moss, S.J., Collingridge, G.L., Pangalos, M.N., Davies C.H., and Calver, A.R. (2004). The GABA(B2) subunit is critical for the trafficking and function of native GABA(B) receptors. Biochem. Pharmacol. 68(8): 1655-66.

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101. Restituito, S., Couve, A., Bawagan, H., Jourdain, S., Pangalos, M.N., Calver, A.R., Freeman, K.B. and Moss, S.J. (2005). Multiple motifs regulate the trafficking of GABAB receptors at distinct checkpoints within the secretory pathway. Mol. Cell. Neurosci. 28(4): 747-56. 102. Goto, H., Terunuma, M., Kanematsu, T., Misumi, Y., Moss, S.J. and Hirata M. (2005). Direct interaction of N-ethylmaleimide-sensitive factor with GABAA receptor β Mol. Cell. Neurosci. 30(2):197-206. 103. Kittler, J.T, Chen, G., Honing, S., Bogdanov, Y., McAinsh, K., Arancibia-Carcamo, I.L., Jovanovic, J.N., Pangalos, M.N., Haucke, V., Yan, Z. and Moss, S.J. (2005). Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission. Proc. Natl. Acad. Sci. USA. 102: 14871-6. 104. Pascual, O., Casper, K.B., Kubera, C., Zhang, J., Revilla-Sanchez, R., Sul, J.Y., Takano, H., Moss, S.J., McCarthy, K. and Haydon P.G. (2005). Astrocytic purinergic signaling coordinates synaptic networks. Science 310:113-6. 105. Jacob, T.C., Bogdanov, Y., Magnus, C., Saliba, R.S., Kittler, J.T., Haydon P.G. and Moss S.J. (2005). Gephyrin modulates the cell surface dynamics of synaptic GABAA receptors J. Neurosci. 25(45): 10469-78. 106. Chen, G., Kittler, J.T., Moss S.J. and Zhen J. Dopamine D3 receptors regulate GABAA receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens. (2006) J. Neurosci 26(9):2513-21. 107. Kanematsu, T., Yasunaga, A., Mizoguchi,Y., Kuratani, A., Kittler, J.T., Jovanovic, J.N., Takenaka, K., Nakayama, K.I., Fukami, K., Takenawa, T., Moss, S.J., Nabekura, J. and Hirata M. (2006) Modulation of GABA(A) receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibition. J. Biol. Chem. 281(31): 22180-9. 108. Bogdanov, Y., Michels, G., Armstrong-Gold, C., Haydon, P.G., Lindstrom, J., Pangalos, M. and Moss, S.J. (2006) Synaptic GABAA receptors are directly recruited from their extrasynaptic counterparts. EMBO J. 25(18): 4381-9. 109. Kuramoto, K., Wilkins, Fairfax, B.P., Revilla-Sanchez, R., Tamaki, K., Couve, A., Calver, A., Horvath, Z., Freeman, K., Carling, D., Huang, L., Gonlazes, C., Cooper, E., Smart, T.G., Pangalos, M.N., and Moss S.J. (2007) Phospho-dependent functional modulation of GABAB receptors by the metabolic sensor AMP-dependent protein kinase. Neuron 53(2): 233-47. 110. Kanematsu, T., Fujii, M., Mizokami, A., Kittler, J.T., Nabekura, J., Moss, S.J. and Hirata. M. (2007). Phospholipase C-related inactive protein is implicated in the constitutive internalization of GABAA receptors mediated by clathrin and AP2 adaptor complex. J. Neurochem. 101(4): 898-905. 111. D’Ascenzo M., Fellin, T., Terunuma, M., Revilla-Sanchez, Meaney D., Auberson Y.P., Moss, S.J. and Haydon P.G. (2007) mGluR5 stimulates gliotransmission in the nucleus accumbens. PNAS 104(6): 1995-2000. 112. Mizokami, A., Kanematsu, T., Ishibashi, H., Yamaguchi, T., Tanida, I., Takenaka, K., Nakayama, K.I., Fukami, K., Takenawa, T., Kominami, E., Moss, S.J., Yamamoto, T., Nabekura, J. and Hirata, M. (2007) Phosholipase C-related inactive protein is involved in trafficking of γcell surface. J. Neurosci. 27(7): 1692-701. 113. Michels, G. and Moss S.J. (2007). GABAA receptors: Properties and Trafficking. Critical reviews in Biochemistry and Molecular Biology 42(1): 3-14. 114. Houston, C.M., Lee, H.H., Hosie, Moss S.J. and T.G.. (2007). Identification of the sites for CaMK-II dependent phosphorylation of GABAA receptors. J. Biol. Chem. 282 17855-65. 115. Tretter, V. and Moss S.J. (2007). Neurosteroid interactions with the GABAA receptor. Cell science Reviews Vol 3 No 4 1742-8130. 116. Lee, H.H., Walker, J.A., Williams, J.R., Goodier, R.R., Payne, J.A. and Moss, S.J. (2007) Direct PKC-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter, KCC2. J. Biol. Chem. 282 29777-84 117. Saliba, R.S., Michels, G., Jacob, T.C., Pangalos, M.N. and Moss, S.J. (2007) Activity-dependent ubiquitination of GABAA receptors regulates their accumulation at synaptic sites. J. Neurosci. 48 13341-13351. 118. Pathak, H., Weissenger, F., Terunuma, M., Carlson, G., Hsu, F-C., Moss, S.J. and Coulter, D. (2007) Disrupted dentate granule cell chloride regulation enhances synaptic excitability during development of temporal lobe epilepsy. J. Neurosci 27:14012-22. 119. Terunuma, M., Xu, J., Vithlani, M., Sieghart, W., Kittler, J.T., Pangalos, M., Haydon, P.G., Coulter, D.A. and Moss S.J. (2008). Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus. J. Neurosci. 28(2):376-84.

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120. Kittler, J.T., Chen,G., Kukhtina, V., Vahedi-Faridi, A., Gu, Z., Tretter, V., Smith, K.R., McAinsh, K., Arancibia-Carcamo, I.L., Saenger, W., Haucke, V. Yan Z., and Moss . S.J. (2008). Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor γ2 subunit. PNAS 105(9): 3616-21. 121. Tretter, V., Jacob, T.C., Mukherjee, J., Fritschy, J.M., Pangalos, M. and Moss S.J (2008). The clustering of GABAA receptor subtypes at inhibitory synapses is facilitated via the direct binding of receptor α2 subunits to gephyrin. J. Neurosci. 28(6):1356-65. 122. Liu, F., Day, M., Luis, C., Muñiz, L.C., Arias, R., Bitran, D., Revilla-Sanchez, R., Grauer, S., Zhang, G, Kelley, C., Pulito, V., Sung, A, Mervis, R.F., Navarra, R., Hirst, W.D., Reinhart, P.H., Marquis, K., Moss, S.J., Pangalos, M.N., and Brandon N.J. (2008). Activation of estrogen receptor beta regulates hippocampal synaptic plasticity and improves memory. Nat. Neurosci. 11(3):334-43. 123. Jacob T.C., Moss S.J. and Jurd, R. (2008). Membrane trafficking of GABAA receptors and the efficacy of synaptic inhibition (2008). Nat. Neurosci. Rev. 9(5):331-43. 124. Saliba, R.S., Pangalos, M. and Moss S.J. (2008). The Ubiquitin-like protein Plic-1 enhances the membrane insertion of GABAA receptors by increasing their stability within the endoplasmic reticulum. J. Biol. Chem. 283(27): 18538-44. 125. Vargas, K., Terunuma, M., Tello, J.A., Pangalos, M., Moss, S.J. and Couve, A. (2008). The availability of surface GABAB receptors is independent of GABA but controlled by glutamate in central neurons. J. Biol. Chem. 283(36):24641-8. 126. Haydon, P.G., Blendy, J., Moss, S.J. and Jackson, R.F. (2008). Astrocytic control of synaptic transmission and plasticity: a target for drugs of abuse? Neuropharmacology 56 Suppl 1:83-90. 127. Smith, K.R., McAinsh, K., Chen, G., Arancibia-Carcamo, I.L., Haucke, V., Yan, Z., Moss, S.J. and Kittler, J.T. (2008). Regulation of inhibitory synaptic transmission by a conserved atypical interaction of GABA(A) receptor beta- and gamma- subunits with the clathrin AP2 adaptor. Neuropharmacology 55(5):844-50. 128. Tretter, V. and Moss, S.J. (2008) GABA(A) Receptor Dynamics and Constructing GABAergic Synapses. Front. Mol. Neurosci. 1:7. 129. Jacob, T.C., Wan, Q., Vithlani, M., Saliba, R.S., Succol, F., Pangalos, M.N. and Moss, S.J. (2009) GABA(A) receptor membrane trafficking regulates spine maturity. Proc. Natl. Acad. Sci. USA 106(30):12500-5. 130. Mukherjee, J., Kuryatov, A., Moss, S.J., Lindstrom, J.M. and Anand, R. (2009) Mutations of cytosolic loop residues impair assembly and maturation of alpha 7 nicotinic acetylcholine receptors. J. Neurochem. 110(6):1885-94. 131. Charych, E.I., Liu, F., Moss, S.J. and Brandon, N.J. (2009) GABA(A) receptors and their associated proteins: Implications in the etiology and treatment of schizophrenia and related disorders. Neuropharmacology 57(5-6):481-95. 132. Fellin, T., Halassa, M.M., Terunuma, M., Succol, F., Takano, H., Frank, M., Moss, S.J. and Haydon, P.G. (2009). Endogenous nonneuronal modulators of synaptic transmission control cortical slow oscillations in vivo. Proc. Natl. Acad. Sci. USA 106(35):15037-42. 133. Saliba, R.S., Gu, Z., Yan, Z. and Moss, S.J. (2009). Blocking L-type voltage-gated Ca2+ channels with dihydropines reduces gamma-aminobutyric acid type A receptor expression and synaptic inhibition. J. Biol. Chem. 284(47):32544-50. 134. Arancibia-Cárcamo, I.L., Yuen, E.Y., Muir, J., Lumb, M.J., Michels, G., Saliba, R.S., Smart, T.G., Yan, Z., Kittler, J.T. and Moss, S.J. (2009). Ubiquitin-dependent lysozomal targeting of GABA(A) receptors regulates neuronal inhibition. Proc. Natl. Acad. Sci. USA 106(41):17552-7. 135. Tretter, V., Revilla-Sanchez, R., Houston, C., Terunuma, M., Havekes, R., Florian, C., Jurd, R., Vithlani, M., Michels, G., Couve, A., Sieghart, W., Brandon, N., Abel, T., Smart, T.G. and Moss, S.J. (2009). Deficits in spatial memory correlate with modified γ-aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus. Proc. Natl. Acad. Sci. USA 106(47):20039-44. Highlighted by Science STKE “Memories of Receptors Endocytosed” L. Bryan Ray 1 December 2009: ec382. 136. Vithlani, M. and Moss, S.J. (2009). The role of GABA(A)R phosphorylation in the construction of inhibitory synapses and the efficacy of neuronal inhibition. Biochem. Soc. Trans. 37(Pt 6):1355-8. 137. Lancaster E., Lai M., Peng X., Hughes E., Constantinescu R., Raizer J., Friedman D., Skeen M.B., Grisold W, Kimura A., Ohta K., Iizuka T., Guzman M., Graus F., Moss S.J., Balice-Gordon R. and Dalmau J. (2009). Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen. Lancet Neurol 9:67-76.

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138. Fujii M., Kanematsu T., Ishibashi H., Fukami K., Takenawa T., Nakayama K.I., Moss S.J., Nabekura J. and Hirata M. (2009). Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of γ-aminobutyric acid type A receptors. J. Biol. Chem. 285:4837-46 139. Boyer, S.B., Clancy, S.M, Terunuma, M., Revilla-Sanchez, R., Thomas, S.M., Moss, S.J., and Slesinger, P.A. (2009). Direct interaction of GABAB receptors with M2 muscarinic receptors enhances muscarinic signaling. J. Neurosci. 29(50):15796-15809. 140. Jurd R, Tretter V, Walker J, Brandon NJ, and Moss SJ. (2010). Fyn kinase contributes to tyrosine phosphorylation of the GABA(A) receptor gamma2 subunit. Mol Cell Neurosci. 44:129-34. 141. Jurd R, and Moss SJ. Impaired GABAA receptor endocytosis and its correlation to spatial memory deficits. Commun Integr Biol. 2010 Mar;3(2):176-8 142. Lee, H.,C., Jurd, R. and Moss S.J. (2010). Tyrosine phosphorylation regulates the degradation of the potassium chloride co-transporter KCC2 During Status Epilepticus. Mol Cell Neurosci. 45(2):173-9 143. Terunuma M.,Vargas, K.J., Wilkins, M.E., Ramírez, O.A., Jaureguiberry M., Pangalos, M.P., Smart, T.G, Moss, S.J.* and Couve, A* (2010). Prolonged activation of NMDA receptors induces the dephosphorylation and modifies the endocytic sorting of GABAA receptors Proc. Natl. Acad. Sci. USA;107(31):13918-23 * = Joint corresponding authors. 144. Dong J, Revilla-Sanchez R, Moss S.J. Haydon PG. Multiphoton in vivo imaging of amyloid in animal models of Alzheimer's disease. (2010). Neuropharmacology. 59 268-75. 145. Terunuma M, Pangalos MN, and Moss SJ. Functional modulation of GABAB receptors by protein kinases and receptor trafficking. (2010). Adv Pharmacol. 58:113-22. 146. Abramian AM, Comenencia-Ortiz E, Vithlani M, Tretter EV, Sieghart W, Davies PA, Moss SJ. (2010). Protein kinase C phosphorylation regulates membrane insertion of GABA(A) receptor subtypes that mediate tonic inhibition. J Biol Chem 285:41795-80. 147. Wang Q, Charych EI, Pulito VL, Lee JB, Graziane NM, Crozier RA, Revilla-Sanchez R, Kelly MP, Dunlop AJ, Murdoch H, Taylor N, Xie Y, Pausch M, Hayashi-Takagi A, Ishizuka K, Seshadri S, Bates B, Kariya K, Sawa A, Weinberg RJ, Moss SJ, Houslay MD, Yan Z, Brandon NJ. (2011). The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function. Mol Psychiatry. 16:1006-23. 148. Lee, H.C., Deeb, T.Z., Walker, J.A., Davies, P.A. and Moss S.J. (2011). NMDA-receptor activation induces the degradation of KCC2 resulting in depolarizing GABAA receptor mediated currents. Nat. Neurosci 14(6): 736-43. Reviewed by Lecker I, Orser B: " Faculty of 1000, 07 Nov 2011. F1000.com/13360061#eval14730195. 149. Deng, Q. Terunuma, M., Fellin, T., Moss S.J., and Haydon P.G. (2011). Astrocytic modulation of A1 receptors stimulates a src kinase dependent regulation of NMDA receptors in somatosensory cortex. Glia 2011 59:1084-93. 150. Porcher, C.S., Hatchett, C.S., Longbottom, R.E, McAinch, K., Sihra, T., Moss, S.J. Alex M. Thomson, A.M. and Jovanovic J.M. (2011). Positive feed-back regulation between GABAA receptor signaling and brain-derived neurotrophic factor (BDNF) release in developing neurons. J. Biol. Chem. 286:21667-77. 151. Vithlani, M., Terunuma, M. and Moss, S.J. (2011). The dynamic modulation of GABAAR trafficking and its role in regulating the plasticity of inhibitory synapses. Physiol Rev. 91:1009-22. 152. Popiolek M, Ross JF, Charych E, Chanda P, Gundelfinger ED, Moss SJ, Brandon NJ, Pausch MH. (2011). D-amino acid oxidase activity is inhibited by an interaction with bassoon at the presynaptic active zone. J Biol Chem. 286(33): 28867-75. 153. Odajima, J., Wills, Z.P., Ndassa, Y. M., Terunuma, M., Kretschmannova, K., Deeb, T.Z., Geng, Y., Gawrzak, S., Quadros, I.M., Newman, J., Das, M. Jecrois, M.E., Yu,Q., Li,1 N., Bienvenu, F., Moss, S.J., Greenberg, M.E., Marto, J.A. and Sicinski, P. (2011). A New Function for Cyclin E in the Brain Revealed by Quantitative Proteomics and Analyses of Cyclin E Knockout Mice. Developmental Cell 21:655-68 154. Tretter, V., Kerschner, B., Milenkovic, M., Ramsden, S.I., Ramerstorfer, J., Saiepour, L., Maric, H., Moss, S.J., Schindelin, S., Harvey, R.J., Sieghart W., and Harvey, K. (2011). Molecular basis of the GABAA receptor α3 subunit interaction with gephyrin. J. Biol Chem. 31(41):14677-87 155. Mukherjee, J., Kretschmannova, K., Gouzer, Maric, H., Ramsden, S., Tretter, V., Michels, G., Harvey,

K., Davies, P., Triller, A., Schindelin, S., and Moss, S.J. (2011). The stabilization of GABAAR at synaptic sites is dependent on the phospho-dependent binding to the inhibitory scaffold protein gephyrin. J. Neurosci. 31:14677-14687. 156. Maric, H., Mukherjee, J., Tretter, V., Moss S.J. and Schindelin, H. (2011). Molecular basis of gephyrin-mediated GABAA receptor clustering. J. Biol Chem. 286 42105-14

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157. Hines, R.M., Davies PA, Moss SJ, Maguire J. (2011). Functional regulation of GABA(A) receptors in nervous system pathologies. Curr Opin Neurobiol. 22(3):552-8. 158. Deeb, T. Z., Lee, H.H.C., Walker, J.A., Davies, P.A. and Moss S. J. (2011) GABAA receptor signalling depends on KCC2 function and membrane potential. Channels. 5:475-81. 159. Sarkar, J. Wakefield, S., MacKenzie, G., Moss, S.J. and Maguire, J. (2011). Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors. J. Neurosci. 31:18198-210. 160. C.L., Lalive, A.L., Tan, K.R., Terunuma, M., Munoz, M.B., Pangalos, M.N., Martínez-Hernández, J., Watanabe, M., Moss, S.J., Luján, R., Luscher, C., and Slesinger, P.A. (2012). Methamphetamine-evoked depression of GABAB receptor signaling in GABA neurons of the VTA. Neuron 73(5):978-89. 161. Saliba, R.S., Kretschmannova, K., and Moss, S.J. (2012). Activity dependent phosphorylation of γ-aminobutyric acid receptors regulates the efficacy of tonic inhibition. EMBO J. 31:2937-51. 162. Oberlander, J.G., Porter, D.M., Onakomaiya, M.M., Penatti, C.A., Vithlani, M., Moss, S.J., Clark, A.S., and Henderson, L.P. (2012). Estrous cycle variations in GABA(A) receptor phosphorylation enable rapid modulation by anabolic androgenic steroids in the medial preoptic area. Neurosci. 226:397-410. 163. Wang, D.S., Zurek, A.A., Lecker, I., Yu, J., Abramian, A.M., Avramescu, S., Davies, P.A., Moss, S.J., Lu, W.Y. and Orser, B.A. (2012). Memory Deficits Induced by Inflammation Are Regulated by α5-Subunit-Containing GABA(A) Receptors. Cell Rep. 2:488-96. 164. Jacob, T.C., Michels, G., Silayeva, L., Haydon, J., Francesca Succol, F., and Moss, S.J. (2012). Benzodiazepines induce subtype specific changes in GABA-A receptor trafficking and decrease synaptic inhibition. Proc. Natl. Acad. Sci. USA 109:18595-600. 165. Sukoff Rizzo, S.J. Neal, S.J., Hughes, Z.A. Beyna, M., Rosenzweig-Lipson, S., Brandon. N.J., and Moss S.J. (2012). Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes. Transl Psychiatry. doi: 10.1038/tp.2012.120. 166. Gonzalez, C., Moss, S.J. and Olsen R.W. (2012). Ethanol promotes clathrin adaptor-mediated endocytosis via the intracellular domain of δ subunit-containing GABAARs. J. Neurosci. 5: 17874-81. 167. Deeb, T.Z., Maguire, J. and Moss SJ. (2012). Possible alterations in GABAA receptor signaling that underlie benzodiazepine resistant seizures Epilepsia. Dec; 53 Suppl 9:79-88. doi: 10.1111/epi.12037. 168. Hines, D.J., Schmitt, L.I., Hines, R.M., Moss, S.J. and Haydon P.G. (2013). Antidepressant effects of sleep deprivation require astrocyte-dependent adenosine mediated signaling. Transl. Psychiatry Jan 15;3:e212. doi: 10.1038/tp.2012.136. 169. Kretschmannova, K., Rochelle M. Hines, R.M., Revilla-Sanchez, R., Tretter, V., Rachel Jurd, R., Keltz, M.B., Moss, S.J.* and Davies, P.A.* (2013). Enhanced tonic inhibition contributes to the hypnotic and amnesic actions of general anaesthetics. J. Neurosci. 33:7264-73.*Co-corresponding authors. 170. Deeb, T.Z., Nakamura, Y., Frost, Davies, P.A. and Moss, S.J. (2013). The inhibitory efficacy of diazepam is selectivity reduced by pathological Cl- loading. Eur J. Neurosci. 38:2453-67. 171. Nani, F., Bright, D, Revilla-Sanchez, R., Tretter, V., Moss, S.J., and Smart T.G. (2013). Tyrosine phosphorylation of GABAA receptor γ2 subunit regulates tonic and phasic inhibition in the thalamus. J. Neurosci; 33:12718-27. 172. Hines, R.M. Hines D.J, Houston, C.M., Mukherjee, J. Haydon, P.G., Tretter, V., Smart, T.G. and Moss, S.J. (2013). Impaired GABAA receptor clustering directly contributes to cognitive deficits in and schizophrenia like phenotypes in rodents. PNAS 110:16628-33. 173. Vithlani, M., Hines, R., Hines, D., Terunuma, M., Sanchez-Revilla, R., Hayden, P., Rios, M., Yan, Z., and Moss S.J. (2013). The anti-depressant efficacy of BDNF is mediated via enhanced GABAAR phosphorylation. J Neurosci. 33:15567-77. 174. Kahle, K.T. Deeb,T.Z. Puskarjov,M., Silayeva,L., Liang, B., Kaila, K., and Moss, S.J. (2013). Modulation of neuronal activity by phosphorylation of the K-Cl transporter KCC2. Trends in Neurosci, 36:726-37. 175. Terunuma, M., Revilla-Sanchez, R., Quadros, I., Deng, Q., Deeb, T., Lumb, M. Piotr Sicinski, P., Haydon, P., Pangalos, M. and Moss, S.J. (2014). Postsynaptic GABAB Receptor Activity Regulates Excitatory Neuronal Architecture and Spatial Memory. J. Neurosci 34 (3):804-816. 176. Engin, E., Konstantin, I., Bakhurin, K.I., Smith, K.S., Hines, R.M., Reynolds, L.M., Tang, W., Rolf Sprengel, R., Moss, S.J. and Rudolph U.W. (2014). Neural basis of benzodiazepine reward: Requirement for α2 containing GABAA receptors in the nucleus accumbens. Neuropsychopharmacology 39(8):1805-15. 177. Abramian, A.M., Eydith Comenencia-Ortiz, E. Amit Mogdil, A., Vien, T., Nakamura,Y. Maguire, J., Terunuma, M., Davies, P.A. and Moss, S.J. (2014). Neurosteroids selectively enhance tonic inhibition by

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promoting protein-kinase C dependent phosphorylation and membrane insertion of GABAARs. Proc. Natl. Acad. Sci. USA; 111(19):7132-7. 178. Comenencia-Ortiz E, Moss SJ, Davies PA. (2014). Phosphorylation of GABAA receptors influences receptor trafficking and neurosteroid actions. Psychopharmacology (Berl). 31(17):3453-65. 179. Petrini EM, Ravasenga T, Hausrat TJ, Iurilli G, Olcese U, Racine V, Sibarita JB, Jacob TC, Moss SJ, Benfenati F, Medini P, Kneussel M, Barberis A. (2014). Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP. Nat Commun. 5:3921-29 180. Rouleau, G., Kahle, K., Merner, N. Friedel,P., Silayeva, S., Liang, B., Khanna, A., Shang, Y., Lachance-Touchette, P., Cynthia Bourassa, C., Levert, A. Dion, P.A Walcott, B., Spiegelman, D., Dionne-Laporte, A., Hodgkinson, A., Awadalla, P., Nikbakht, H., Majewski, J., Cossette, P., Tarek, D., Moss, S.J. and Medina, I (2014). Genetically-encoded impairment of KCC2 cotransporter functional regulation in human idiopathic generalized epilepsy. EMBO Reports 15(7):766-74. 181. Adelfinger, A., Turecek R., Ivankova, K., Jensen, A., Moss, S.J., Gassmann, M., and Bettler, B. (2014). GABAB receptor phosphorylation regulates KCTD12-induced fast K+ current desensitization. Biochem Pharmacol. 91(3):369-79. 182. Huyghe, D., Nakamura,Y, Terunuma., M., Pangalos, M., and Moss SJ (2014). Glutamine synthetase stability and subcellular localization are regulated by g-aminobutyric acid type B receptors. J. Biol 289(42):28808-1. 183. Terunuma M, Haydon PG, Pangalos MN, Moss SJ. (2015). Purinergic receptor activation facilitates astrocytic GABAB receptor calcium signalling. Neuropharmacol. 88: 74-81. 184. Nakamura Y, Darnieder LM, Deeb TZ, Moss SJ. (2015) Regulation of GABAARs by Phosphorylation. Adv Pharmacol 72:97-146. 185. Silayeva, L., Deeb, T.Z., Hines, R.M., Kelley, M.R., Munoz, M.B., Lee, H.H., Brandon, N.J., Dunlop, J., Maguire, J., Davies, P.A. and Moss S.J. (2015). KCC2 activity plays an essential role to limit the onset and severity of Status Epilepticus PNAS 112(11):3523-8. 186. Sivakumaran, S., Cardarelli, R., Maguire, J., Kelley, M., Silayeva, L., Morrow, D., Mukherjee, J., Moore, Y., Mather, R., Duggan, M., Brandon, N., Dunlop, J., Zicha, S., Moss, S.J.* and Deeb, T.* (2015). Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo. J. Neurosci 35:8291-6. *Co-corresponding authors. 187. Vien, T., Modgil, A., Abramian, M., Jurd, R., Walker, J., Rudolph, U., Maguire, J., Davies, P., and Moss S.J. (2015). Preventing the phospho-dependent regulation of γ-aminobutyric acid type A receptors is sufficient to reproduce the core symptoms of autism spectrum disorders. PNAS 112:14805-10 188. Mircsof, D., Langouët, M., Rio, M., Moutton, S., Siquier-Pernet, K., Bole-Feysot, C., Cagnard, N., Nitschke, P., Gaspar, L., Žnidarič, M., Alibeu, O., Fritz, A.K., Wolfer, D.P., Schröter, A., Bosshard, G., Rudin, M., Koester, C., Crestani, F., Seebeck, P., Boddaert, N., Prescott K., D.D., Study, D., Hines, R., Moss, S.J., Fritschy, J.M., Munnich, A., Amie, J., Brown, S.A., Tyagarajan, S.K. and Colleaux, L. (2015). Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defects. Nat Neurosci. 18:1731-6. 189. Atsushi Saito, A., Taniguchi, Y., Rannals, M.D., Merfeld, E.B., Ballinger, M.D., Ohtani, M.K., Gurley, D.A., Sedlak, T.W., Cross, A., Moss, S.J., Brandon, N.J., Maher, B.J., and Kamiya, A. (2015). Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1. Mol Psy. Jan 5. doi: 10.1038/mp.2015.203. 190. Trattnig, S. Gasiorek, A., Deeb, A., Ortiz, E., Moss, S.J., Jensen, A. and Davies, P. (2016). Copper and Protons Directly Activate the Zinc-Activated Channel. Biochem Pharmacol. 103:109-17. 191. Munoz, M.B., Padgett, C., Rifkin, R. Terunuma, M., Wickman, K., Contet, C., Moss, S.J., Slesinger, P.A. (2016). A role for the GIRK3 subunit in methamphetamine-induced attenuation of GABAB receptor-activated GIRK currents in VTA dopamine neurons. J. Neurosci. 36:3106-14. 192. Nakamura, Y., Morrow, D.H., Modgil, A., Huyghe, D., Deeb, T.Z., Lumb, M.J., Davies, P.A. and Moss, S.J. (2016). Proteomic characterization of inhibitory synapses using a novel pHluorin-tagged GABAAR α2 subunit knockin mouse. J. Biol. Chem. 291(23):12394-407. 193. Kelley, M.R., Deeb, T.Z., Brandon, N.B., Dunlop, J., Davies, P. and Moss, S.J. (2016). Compromising KCC2 transporter activity enhances the development of continuous seizure activity, Neuropharmacol doi: 10.1016/j.neuropharm.2016.04.029. 194. Vien, T.N., Moss, S.J. and Davies PA. (2016). Regulating the Efficacy of Inhibition Through Trafficking of γ-Aminobutyric Acid Type A Receptors.mAnesth Analg. 2016 Jun 9. [Epub ahead of print.]

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195. Walker K.R., Modgil, A., Albrecht, D., Lomoio, S., Haydon, P., Moss, S.J. and Tesco, G. (2016). Genetic deletion of the clathrin adaptor GGA3 reduces anxiety and alters GABAergic transmission. PLOS One. 18;11(5):e0155799. doi: 10.1371/journal.pone.0155799. 196. MacKenzie G, O'Toole KK, Moss SJ, Maguire J. (2016). Compromised GABAergic inhibition contributes to tumor-associated epilepsy. Epilepsy Res. 126:185-96. 197. Dana M. Cairns, D.M., Chwalek, K., Moore, Y.E., Kelley, M.R., Rosalyn D. Abbott, R.D., Moss, S. and Kaplan,D.L. (2016). Expandable and Rapidly Differentiating Human Induced Neural Stem Cell Lines for Multiple Tissue Engineering Applications. Stem Cell Reports /10.1016/j.stemcr.2016.07.017. 198. Newman EL, Gunner G, Huynh P, Gachette D, Moss SJ, Smart TG, Rudolph U, DeBold JF, Miczek KA. (2016). Effects of Gabra2 Point Mutations on Alcohol Intake: Increased Binge-Like and Blunted Chronic Drinking by Mice. Alcohol Clin Exp Res. doi: 10.1111/acer.13215. 199. Modgil, M., Parakala, M.L., Ackley, M.A., Doherty, J.J., Moss, S.J.* and Davies, P.A.* (2016). Endogenous and synthetic neuroactive steroids enhance sustained increase in the efficacy of GABAergic inhibition dependent upon PKC activity. Neuropharmacol pii: S0028-3908(16)30460-9. doi: 10.1016/j.neuropharm.2016.10.010. * = Joint corresponding authors. 200. Kang, J.I., Vien, T., Chadchankar, J., Deeb, T.Z., Mighdoll, M., Hyde, T.M., Mather, R. J., Brandon, Dunlop, J.D. and Moss, S.J. (2017). Deficits in the activity of presynaptic γ-aminobutyric acid type B receptors contribute to neuronal hyperexcitability in Fragile X Syndrome. J. Biol. Chem. Feb 17. pii: jbc.M116.772541. doi: 10.1074/jbc.M116.772541. 201. Rifkin, R.A., Moss, S.J. and Slesinger, P.A. (2017). G protein-gated potassium channels: a link to drug addiction. TIPS pii: S0165-6147(17)30023-8. doi: 10.1016/j.tips.2017.01.007. 202. Wobst, H.J., Wesolowski, S.S., Chadchankar, J., Delsing, L., Jacobsen, S., Mukherjee, J., Deeb, T.Z., Dunlop, J., Brandon, N.J. and Moss S.J. (2017). Cytoplasmic Relocalization of TAR DNA-binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies associated with ALS in vitro. Frontiers in Molecular Neuroscience 24; 10:46. doi: 10.3389/fnmol.2017.00046. 203. Wobst, H.J., Delsing, L., Brandon, N.J. and Moss SJ (2017). Truncation of the TAR DNA-binding Protein 43 Is Not a Prerequisite for Cytoplasmic Relocalization, and Is Suppressed by Caspase Inhibition and by Introduction of the A90V Sequence Variant. Plos one 12(5):e0177181. doi: 10.1371/journal.pone.0177181. 204. Moore, Y.E., Kelly, M.R., Brandon, N.J., Deeb, T.Z. and Moss S.J. (2017). Seizing Control of KCC2: A New Therapeutic Target for Epilepsy. TINS, (17)30123-6. 205. Cardarelli, R.A., Deeb, T.Z., Jones, K., McWilliams, K., Sharpe, P.M., Burnham, M.P., Pisella, P., Guyot, J., Dekker, N., Isaacs, Robert, R.R., Lavieri, R., Wobst, H.J., Silayeva, L., Morrow, D., Mather, R.J. Zicha, S., Davies, P.A., Medina, I., Brandon, N.J., Dunlop, J. and Moss, S.J. (2017). The small molecule CLP257 does not increase KCC2 activity or functional expression. Nat Med (in press). 206. Mukherjee, J., Cardarelli, R.A. Belarif, Y., Pangalos, M.N, Brandon, N.J. Triller, A., Jamie Maguire, J. and Moss S. J. (2017). Estradiol modulates the efficacy of fast synaptic inhibition by decreasing the dwell time of γ-aminobutyric acid receptors at inhibitory synapses. PNAS (in press). 207. Melón, C., Hooper, A., Yang, X., Moss, S.J. and Maguire, J. (2017). Inability to suppress the HPA axis during pregnancy and the postpartum period induces deficits in maternal care and postpartum depression-like behaviors. Biological Psychiatry (submitted). 208. Conway, L.C., Cardarelli, R.A., Moore, Y.E., Jones, K., McWilliams, L.J., Baker, D., Burnham, M.P., Bürli, R.W., Wang, Q., Brandon, N.J., Moss, S.J.* and Deeb, T.Z.* (2017). N-ethylmaleimide increases KCC2 activity by modulating transporter phosphorylation. J. Biol. Chem. (under revision). *=joint corresponding authors. 209. Newman, E.L., Terunuma, M., Wang, T., Hewage, N., Bicakci; M.B., Moss; S.J., DeBold, J.F., Miczek, K.A. (2017). A role for prefrontal cortical NMDA receptors in murine alcohol-heightened aggression. Biol. Psych (submitted). 210. Hines, R.M., Maric, H.M., Hines, D.J., Modgil, A., Panzenelli, P., Nakamura, Y., Nathanson, A., Cross, A., Brandon, N., Davies, P., Fritschy, J.M., Schindelin, H., and Moss S.J. (2017). Decreasing the interaction of the GABAAR α2 subunit with collybistin results in spontaneous seizures and premature death. Neuron (submitted).

Patents Haydon, P., Lee, J., Dong, J., Moss, S.J. and Revilla-Sanchez, R. (2013). Uridine diphosphate derivatives, compositions and methods for treating neurodegenerative disorders-US Patent 8,598,141.

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Books 1. Moss S.J. and Henley J.M. (Eds) (2002): Receptor and Ion Channel Trafficking. Oxford University Press. 2. Kittler J.T. and Moss S.J. (Eds) (2006): The Dynamic Synapse. CRC Taylor and Francis. Book Chapters 1. Darlison, M.G., Hicks, A.A., Lai, F.A., Moss, S.J., Besson, D.M.W., Cockroft, V.B. and Barnard E.A. (1987). Molecular Biology of Nicotinic Acetylcholine Receptors from Chicken Muscle and Brain in Mechanisms of Action of the Nicotinic Acetylcholine Receptor, (Ed. A. Maelicke) Springer Verlag, Berlin. 2. Darlison, M.G., Cockroft, V.B., Hicks, A.A., Squire, M.D., Moss, S.J. and Barnard, E.A. (1987). Analysis of Cloned DNA Encoding Nicotinic Acetylcholine Receptor Subunits from the Central Nervous System In Mechanisms and Development of the Nervous System, J. Wiley & Sons, Chichester, England. 3. Barnard, E.A., Darlison, M.G., Harvey, R., Marshall, J., Moss, S.J., Sattelle, D.B., Smart, T.G. and Vreugdenhil E. (1990). Cloned Genes for Ligand Operated Ion Channels and their Expression In Vitro Biology and Medicine of Signal Transduction, Editor. Y. Nishizuka, Raven Press, New York, p 25-39. 4. Blackstone, C.D., L. Raymond, Moss, S.J. and R.L. Huganir. Regulation of a Non-NMDA receptor by protein phosphorylation (1992). In: Fida research foundation Symposium Series, Vol. 9: Excitatory Amino Acids, editor R.P. Simon, Thieme, New York pp 15-20. 5. Millar, N.S., Moss, S.J. and Green W.N. Assembly, post transitional processing and sub cellular localisation of ion channels (1995). In: Ion channels a practical approach, Editor R. Ashley, IRL press, Oxford p191-216. 6. Moss, S.J., McDonald, B., Gorrie, G.H., Krishek, B. J., and Smart T.G. Regulation of GABAA receptors by Protein phosphorylation. (1995) In GABA: Receptors, Transporters, and Metabolism, Editors. Tanka/Bowery, Birkhauser Ltd, Basel Switzerland, p 173-185. 7. Swope, S.L., Moss S.J., Raymond L.A. and Huganir R.L. (1999). Regulation of ligand gated ion channels by protein phosphorylation. Adv Second Messenger Phosphoprotein Res. 33 49-78. 8. Smart T.G., Thomas, P., Brandon, N.J. and Moss S.J. (2001). Heterologous regulation of GABAA receptors: protein phosphorylation. In Pharmacology of GABA and Glycine Neurotransmission (Handbook of Experimental Pharmacology), Editor H. Möhler Springer-Verlag, Berlin pp.195-226. 9. Brandon, N.J, Smart, T.G. and Moss, S.J. (2000). Regulation of GABAA receptors by protein phosphorylation. In: GABA in the Nervous System: The View at Fifty Years Editors D.L. Martin and R. Olsen, Lippincott Williams & Wilkins, Philadelphia, PA, U.S.A. 10. Arancibia-Carcano, I.L., Fairfax, B.P., Moss S.J. and Kittler J.T. (2006). Studying the localization, surface stability and endocytosis of neurotransmitter receptors by antibody labelling (2006) In The Dynamic Synapse, Editors; Kittler J.T. and Moss S.J. 11. Arancibia-Carcano, I.L. and Moss S.J. (2006) Molecular organization and assembly of the central inhibitory postsynapse. Cell communication in the nervous systems 43 p 24-47. 12. Couve A, Moss, S.J. Pangalos MN. (2007). The unusual functioning of the GABAB receptor heterodimer: an old receptor teaching new functional tricks? The GABA Receptors (3rd Edition) Eds S.J. Enna and Hanns Mohler. Humana Press.