strategic center for clinical cancer research clinical cancer research using emerging advanced...
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Strategic Center for Clinical Cancer Research
Clinical Cancer Research using Emerging Advanced Technologies for Health
Title Slide
Strategic Center for Clinical Cancer Research
Lancet: 365,1727,2005
Breast Cancer Mortality in Women, 1951-2000
Strategic Center for Clinical Cancer Research
Proteomics
ProteomicsTumour biologyNano technology Bioinformatics
GenomicsClinical Oncology
The CREATE Health team
Strategic Center for Clinical Cancer Research
CREATE Health BoardRepresentatives from Lund University and
Industry
Director Carl BorrebaeckDeputy Carsten Rose
BioinformaticsC Peterson
DNA/RNA arraysÅ Borg
RNA/protein arrays
C Borrebaeck
Nano-technologyT Laurell
Clinical OncologyC Rose
Tumor cell biology
S Påhlman
J HäkkinenJ VallonC Rovira
ProteomicsP James
Scientific Advisory BoardSteering Committee
IPR Review board Administration
F LevanderG Marko-Varga
J Nilsson C Graffman
M RidderheimH AxelsonC Larsson
Scientific Secretary
Financial Officer
S EkC Wingren
Organisation
Strategic Center for Clinical Cancer Research
Localisation of BMC and USil
Strategic Center for Clinical Cancer Research
You are here!
Localisation at the Biomedical Centre
Strategic Center for Clinical Cancer Research
• To create an integrative approach to solve complex clinical problems, by developing novel techniques - ”from bedside to bench and back again”• To create a substantial social impact for the patient through direct application of research for selection of an optimal, individually-based, cancer treatment
Mission and Vision Statements
Strategic Center for Clinical Cancer Research
Clinical focus
To associate specific gene and/or protein signatures with:
• Treatment-induced drug resistance• Treatment response & optimisation• Tumour relapse & survival time
To identify novel targets for antibody-based therapy
Research and Development
Strategic Center for Clinical Cancer Research
Sample handling Technology development & application
Sample collection
Sample analysis
Dataanalysis & mining
Sample storage & tracking
Sample processning
Diagnostics/Treatment
Clinic CREATE Health Centre Clinic
Investigators:Carl BorrebaeckÅke BorgPeter James Thomas LaurellCarsten PetersonSven PåhlmanCarsten Rose
Clinicaltransfer
Diagnosticvalidation
Treatmentvalidation
Technology development
CREATE Health Work flow
Strategic Center for Clinical Cancer Research
Improved diagnosis • Increased analytical sensitivity and capacity
Improved prediction of disease progression• Proteome-wide biomarker identification from fine needle/sure-cut biopsies
Increased survival • Disease stratification and tailoring of therapy• Tumour specific antibodies for therapy
Benefits for the patients
Strategic Center for Clinical Cancer Research
Genomics focus• define gene defects that are hereditary • define chromosomal defects arising in cancer• develop pathway focused gene monitoring methods• find novel microRNA markers of cancer
Proteomics focus• discover protein markers of disease in cancer cells• validate markers in serum for subsequent blood tests• develop peptide monitoring for plasma analysis
Discovery Projects
Strategic Center for Clinical Cancer Research
Antibody microarrays• antibody microarray based oncoproteomics• nanostructured high performance chips for fluorescence/MS• protein sampling in nanoscale for LCM single cell proteome
Proteomic data basis & tools• BASE & Proteios integrated algorithms for breast & lymphomas• Cell reconstruction & validation
Practical Application Projects
Strategic Center for Clinical Cancer Research
Principle of Antibody Microarrays
Strategic Center for Clinical Cancer Research
Analysis of serum proteomes from 30
pancreatic carcinoma patients and 15 healthy individuals
• red - upregulated• black - no change
• green - down regulated
100% Sensitivity100% Specificity
Practical Example:Pancreatic Adenocarcinomas
Healthy Carcinoma
Strategic Center for Clinical Cancer Research
CREATE Health is actively engaged in developing its discoveries to benefit society and has a special board for IP issues.
The CREATE Health team has generated > three world-wide patents/year over the past five years, ranging from basic research to applied biomedical inventions
As a result, six spin-off firms have been created, some with > 100 employees.
Technology Transfer and Commercialisation
Strategic Center for Clinical Cancer Research
www.createhealth.lth.se
End Slide