strategies and tools for the environmental laboratory ... · strategies and tools for the...
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Strategies and Tools for
the Environmental
Laboratory
Improving Operational
Efficiency and Return on
Invested Capital
Agilent Technologies, Inc.
Craig Marvin
GPD Solutions Business Manager
June 11, 2013
1
Today’s Challenges Expecting More from Less
• Increasing cost of ownership
• Trace analysis in complex matrices
Business Challenges
• Less time for method development
• Limited technical experience
Resource Allocation
• Demands for higher throughput
• Quicker return on capital investment
Optimizing Efficiency
Laboratory Strategies
2 July 2013
Presentation Overview
Laboratory Strategies
3
Cost of Operation - Helium Availability
Reducing Maintenance & Enhancing Performance
Rapid Deployment for Quicker Financial Returns
July 2013
Market Situation The most common carrier gas for GC is in short supply!
Unreliable supply of helium worldwide and increasing prices have
laboratories seeking alternative carrier gas solutions
Laboratory Strategies
4 July 2013
Carrier Gas Decision Tree Method Translation or Helium Conservation
Consider migration to H2 Consider migration to N2 He Conservation
GC/MS specific H2
considerations
Is the customer willing to convert
to alternative gasses?
Is the Application based on
GC or GC/MS?
Does the current GC method
have more than enough resolution?
No
No
Yes
Yes
GC/MS GC
Laboratory Strategies
5 July 2013
Carrier Gas Savings CalculatorChange values in gray boxes to calculate savings for your operating parameters
Method:
Column:
Gas Flow Conditions
He Carrier Flow (mL/min): 1.5
He Split flow (mL/min): 190
Gas Saver Flow (mL/min): 20
Gas Saver On (min): 3
Run Time(min.): 15
Gas Volume in Cylinder (L): 8000
Runs per Day: 30
He Cylinder Cost ($): 300
N2 Cylinder Cost ($): 60
Parameter No ConservationWith
Conservation
Daily He Usage (L) 276 25
He Cylinder Life (days) 29 320
Daily N2 Usage (L) 0 21
N2 Cylinder Life (days) 0 376
Yearly He Cost ($) 3,774 342
Yearly N2 Cost ($) 0 58
Yearly Total Gas Cost ($) 3,774 400
Savings vs. No Gas Saver ($) 0 3,374
Typical Split GC method
30m x 0.25mm x 0.25um
Helium Savings Calculator Extend supply and lower cost using conservation techniques
• Helium Conservation
– Helium cylinder life extended to
~12 months
– Greatly reduces annual gas costs
• Additional Benefit
– Reduces dependence on Helium
deliveries
– Ensures business continuity
Laboratory Strategies
6 July 2013
www.agilent.com/helium/update
System Maintenance
Greatest disruption to workflow and productivity
Laboratory Strategies
7
System venting and disassembly of MS source
Manual cleaning requires expertise
Reassembly and system re-equilibration
System offline for full day of operation
July 2013
Self-Cleaning Ion Source Using H2 to Clean to MS Source
5 0 1 0 0 1 5 0 2 0 0 2 5 0 3 0 0 3 5 0 4 0 0 4 5 0 5 0 0
0
5 0 0 0
1 0 0 0 0
1 5 0 0 0
2 0 0 0 0
2 5 0 0 0
3 0 0 0 0
3 5 0 0 0
4 0 0 0 0
4 5 0 0 0
5 0 0 0 0
5 5 0 0 0
6 0 0 0 0
6 5 0 0 0
7 0 0 0 0
7 5 0 0 0
m / z - - >
A b u n d a n c e
A v e r a g e o f 1 . 9 6 9 t o 1 0 . 0 4 6 m i n . : E I - b a c k g r d - r e p 0 . D \ d a t a . m s
9 1 . 0
5 5 . 0
1 3 3 . 1
1 7 8 . 1
2 1 5 . 1
2 5 2 . 2
2 8 9 . 1
3 2 6 . 2 3 6 0 . 2 4 0 2 . 3 4 4 0 . 3 4 7 6 . 3
Very Dirty Source:
Background
Spectrum
50,000
5 0 1 0 0 1 5 0 2 0 0 2 5 0 3 0 0 3 5 0 4 0 0 4 5 0 5 0 0
0
5 0 0 0
1 0 0 0 0
1 5 0 0 0
2 0 0 0 0
2 5 0 0 0
3 0 0 0 0
3 5 0 0 0
4 0 0 0 0
4 5 0 0 0
5 0 0 0 0
5 5 0 0 0
6 0 0 0 0
6 5 0 0 0
7 0 0 0 0
7 5 0 0 0
m / z - - >
A b u n d a n c e
A v e r a g e o f 1 0 0 . 0 0 9 t o 1 1 0 . 0 2 7 m i n . : E I - b a c k g r d - r e p 3 . D \ d a t a . m s
7 8 . 14 5 . 1 2 0 6 . 9 2 8 1 . 11 3 4 . 9 3 5 5 . 1 4 4 5 . 52 4 1 . 61 6 8 . 1 3 2 0 . 6 3 8 8 . 9 4 7 7 . 9
After Cleaning
with H2
50,000
5 0 1 0 0 1 5 0 2 0 0 2 5 0 3 0 0 3 5 0 4 0 0 4 5 0 5 0 0
0
2 0
4 0
6 0
8 0
1 0 0
1 2 0
1 4 0
1 6 0
1 8 0
2 0 0
2 2 0
2 4 0
m / z - - >
A b u n d a n c e
A v e r a g e o f 1 0 0 . 0 0 9 t o 1 1 0 . 0 2 7 m in . : E I - b a c k g r d - r e p 3 . D \ d a t a . m s
7 8 . 1
4 5 . 1 2 0 6 . 9
2 8 1 . 1
1 3 4 . 9 3 5 5 . 1
4 4 5 . 52 4 1 . 61 6 8 . 1 3 2 0 . 6 3 8 8 . 9 4 7 7 . 9
Expanded scale
50
Laboratory Strategies
8 July 2013
Cleaning Restores Analyte (OFN) Detection Comparable to manual cleaning?
4 . 1 0 4 . 1 2 4 . 1 4 4 . 1 6 4 . 1 8 4 . 2 0 4 . 2 2 4 . 2 4 4 . 2 6 4 . 2 8 4 . 3 0 4 . 3 2 4 . 3 4 4 . 3 6 4 . 3 8
1 4 0 0 0 0
1 4 2 0 0 0
1 4 4 0 0 0
1 4 6 0 0 0
1 4 8 0 0 0
1 5 0 0 0 0
1 5 2 0 0 0
1 5 4 0 0 0
1 5 6 0 0 0
1 5 8 0 0 0
1 6 0 0 0 0
1 6 2 0 0 0
1 6 4 0 0 0
1 6 6 0 0 0
1 6 8 0 0 0
1 7 0 0 0 0
1 7 2 0 0 0
1 7 4 0 0 0
1 7 6 0 0 0
1 7 8 0 0 0
T i m e - - >
A b u n d a n c e
I o n 2 4 1 . 0 0 ( 2 4 0 . 7 0 t o 2 4 1 . 7 0 ) : O F N - p r e c o n d - 0 - r e p 0 0 . D \ d a t a . m s
4 . 1 0 4 . 1 2 4 . 1 4 4 . 1 6 4 . 1 8 4 . 2 0 4 . 2 2 4 . 2 4 4 . 2 6 4 . 2 8 4 . 3 0 4 . 3 2 4 . 3 4 4 . 3 6 4 . 3 8
0
5 0 0
1 0 0 0
1 5 0 0
2 0 0 0
2 5 0 0
3 0 0 0
3 5 0 0
4 0 0 0
4 5 0 0
5 0 0 0
5 5 0 0
6 0 0 0
6 5 0 0
7 0 0 0
7 5 0 0
T im e - - >
A b u n d a n c e
T I C : O F N - p o s t c o n d - 1 - p r e t u n e - r e p 0 2 . D \ d a t a . m s
S:N > 50 pk-pk
> 200 rms
S:N ≈ 1 pk-pk
> 2 rms
Very dirty
source before
cleaning
After cleaning
with H2
Laboratory Strategies
9 July 2013
App. optimized
consumables
Pre-Configured Analyzers Increasing the Value Proposition
Application
report
System with
application setup
w/o Analyzer
Familiarization
Common
Components Factory Configured with Chemical Testing
Field Verification
Std. HW, SW Customer
Configured Analyzer Solution
Laboratory Strategies
10 July 2013
Focus your team on analyses; not method development!
The Value of Analyzers and Application Kits Reduce the time required for system deployment
…Faster Application Startup with a Quality Method
Sample
Ready
Order Fulfillment
Standard Installation &
Familiarization
Customer Method Development
and Validation
Agilent Method
Development
Application checkout
Analyzer Installation &
Familiarization
Customer Method
Validation
Order Fulfillment
Agilent Analyzers
End User Configured
Order
Placement
Laboratory Strategies
11 July 2013
Sample
Ready
Analyzers of Interest Environmental Laboratory Focus
GC/MS/MS Solutions
• Polycyclic Aromatic Hydrocarbons (PAHs)
• Pesticides & Environmental Pollutants
GC/MS Solutions
• Pesticides
• Volatiles and Semi Volatiles
• Polycyclic Aromatic Hydrocarbons (PAHs)
GC Solutions
• Greenhouse Gases
Laboratory Strategies
12 July 2013
Analyzer Value to Customers Helping you enhance your competitive advantage
Alleviate Resource Pressure
Guaranteed Method
Optimized Performance
Advanced Technologies
Quicker Deployment and Return
Laboratory Strategies
13 July 2013
Thank you Let’s Continue the Conversation
Laboratory Strategies
14 July 2013
2013.06.18 Page 15
Q&A
Question 1.
• Should end users, or the scientists in the lab, be looking to
validate the results that they have obtained using a certain
instrument?
• And do you think that, if they have used another instrument,
they would be likely to get different results? Because we are
sometimes talking about very trace amounts of material, or
very low volumes of samples. So what is your
recommendation when it comes to validating results?
2013.06.18 Page 16
Question 2.
• The next point I wanted to bring up was around sample prep.
What are some of the trends that you're seeing in sample
prep now, and how can it help with minimizing some of the
current problems.
2013.06.18 Page 17
Question 3.
• Can you elaborate a little bit more on how you clean the ion
source using hydrogen?
2013.06.18 Page 18
Question 4.
• What is Agilent’s approach to field testing?
2013.06.18 Page 19