strategies for identifying source of lbp
TRANSCRIPT
Strategies for Identifying Source of LBPClinical & Imaging Predictor Variables
Douglas Beall, MD
Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Predictor Variables:
A. 1 or 2 Levels That are Likely to be Symptomatic
B. Pfirrmann Grade DDD of 3-6
C. Modic Changes of Grade II or Less
D. Normal Disc or Contained Disc Protrusion at Index Level
Discogenic Low Back Pain
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1 or 2 Levels of Degenerative Disc Disease15
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DDD More Likely to be Painful –Greater Amount of Disc Degeneration
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DDD Characteristics More Likely to be Painful –Modic Changes
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Predictor Variables:
A. 1 or 2 Levels That are Likely to be Symptomatic
B. Pfirrmann Grade DDD of 3-6
C. Modic Changes of Grade II or Less
D. Normal Disc or Contained Disc Protrusion at Index Level
Discogenic Low Back Pain
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Pfirrmann Grade DDD of 3-6
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Predictor Variables:
A. 1 or 2 Levels That are Likely to be Symptomatic
B. Pfirrmann Grade DDD of 3-6
C. Modic Changes of Grade II or Less
D. Normal Disc or Contained Disc Protrusion at Index Level
Discogenic Low Back Pain
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Modic Changes of Grade II or Less
Modic Changes:
• Follows a Progressive Course
– Type 1 – Fluid (↓T1/↑T2 Signal)
– Type 2 – Fat (↑T1 & ↓T2 Signal
[With Fat Sat])
– Type 3 – Sclerosis (↓T1 & T2 Signal)
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Modic Type 1 End-Plate Changes
Sag T1 Sag T2 Sag STIR
Sagittal Post-Contrast T1
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Modic Type 2 End-Plate Changes
Sag T1 Sag T2
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Modic Type 3 End-Plate Changes - Not OK for Inclusion
Sag T1 Sag T2
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Predictor Variables:
A. 1 or 2 Levels That are Likely to be Symptomatic
B. Pfirrmann Grade DDD of 3-6
C. Modic Changes of Grade II or Less
D. Normal Disc or Contained Disc Protrusion at Index Level
Discogenic Low Back Pain
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Herniation – is a general term &
the process may be further characterized as
protrusions or extrusions based on the shape of
the displaced disc material
Protrusion Extrusion
Herniation
Disc Herniations – Morphology
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Protrusion Extrusion27
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Protrusion – If greatest distance of the edges of the protruded material is ≤ theedges of the normal disc in the same plane (best determined in sag plane)
Extrusion – If the distance the disc is
displaced (at least in one plane) is > the
distance between the edges of the base of the
herniation As measured in the same plane
Disc Herniations – Morphology
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Case 2
Performed MBB’s at L3-4 and L4-5 w/ < 50% relief of LBP
Discogram concordant at L4-5 & pain decreased from 6/10 to 0/10 after anesthetic injection at L4-L5
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Normal Protrusion Extrusion30
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Discogenic LBP Patients – Case 1
2 Level DDD w/ Pfirrmann grade 6 disc at L4-5
Looks ~ same height as L5-S1 disc but 5-1 disc most often shorter even when normal
OK even w/ higher grade disc degeneration @ L4-5 (<Pfirrmann Gr 7)
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Discogenic LBP Patients – Case 1
Discogram concordant at L4-5 & L5-S1 & pain decreased from 6/10 to 0/10 after anesthetic injection at L4-5 and L5-S1
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Predictor Variables – Rule Out
Discogenic Low Back Pain
A. 3 or More Levels of DDD Likely to be Symptomatic
B. Pfirrmann Grade DDD of 1-2 or 7-8C. Modic Grade III Changes D. Disc Extrusions or SequestrationE. Neural Compression due to Spinal StenosisF. Spondylolisthesis of Grade 2 or HigherG. Lumbar SpondylitisH. Spinal Deformity with Cobb Angle Greater
than 15 DegreesI. Any Fracture at Incident Level
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Predictor Variables – Rule Out
Discogenic Low Back Pain
A. 3 or More Levels of DDD Likely to be Symptomatic
B. Pfirrmann Grade DDD of 1-2 or 7-8C. Modic Grade III Changes D. Disc Extrusions or SequestrationE. Neural Compression due to Spinal StenosisF. Spondylolisthesis of Grade 2 or HigherG. Lumbar SpondylitisH. Spinal Deformity with Cobb Angle Greater
than 15 DegreesI. Any Fracture at Incident Level
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Pfirrmann Grade Disc Degeneration of 3-6
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Predictor Variables – Rule Out
Discogenic Low Back Pain
A. 3 or More Levels of DDD Likely to be Symptomatic
B. Pfirrmann Grade DDD of 1-2 or 7-8C. Modic Grade III Changes D. Disc Extrusions or SequestrationE. Neural Compression due to Spinal StenosisF. Spondylolisthesis of Grade 2 or HigherG. Lumbar SpondylitisH. Spinal Deformity with Cobb Angle Greater
than 15 DegreesI. Any Fracture at Incident Level
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Predictor Variables – Rule Out
Discogenic Low Back Pain
A. 3 or More Levels of DDD Likely to be Symptomatic
B. Pfirrmann Grade DDD of 1-2 or 7-8C. Modic Grade III Changes D. Disc Extrusions or SequestrationE. Neural Compression due to Spinal StenosisF. Spondylolisthesis of Grade 2 or HigherG. Lumbar SpondylitisH. Spinal Deformity with Cobb Angle Greater
than 15 DegreesI. Any Fracture at Incident Level
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Extrusion – may be further classified
into migrated discs or sequestrations.
SequestrationMigrated disc
Extrusion
Disc Herniations – Morphology
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Protrusion Extrusion & Inferior Migration
Extrusion & Sequestered Disk
Fragment
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Predictor Variables – Rule Out
Discogenic Low Back Pain
A. 3 or More Levels of DDD Likely to be Symptomatic
B. Pfirrmann Grade DDD of 1-2 or 7-8C. Modic Grade III Changes D. Disc Extrusions or SequestrationE. Neural Compression due to Spinal StenosisF. Spondylolisthesis of Grade 2 or HigherG. Lumbar SpondylitisH. Spinal Deformity with Cobb Angle Greater
than 15 DegreesI. Any Fracture at Incident Level
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Predictor Variables – Rule Out
Discogenic Low Back Pain
A. 3 or More Levels of DDD Likely to be Symptomatic
B. Pfirrmann Grade DDD of 1-2 or 7-8C. Modic Grade III Changes D. Disc Extrusions or SequestrationE. Neural Compression due to Spinal StenosisF. Spondylolisthesis of Grade 2 or HigherG. Lumbar SpondylitisH. Spinal Deformity with Cobb Angle Greater
than 15 DegreesI. Any Fracture at Incident Level
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Grades of Spondylolisthesis – Grade II or Higher Rule Out
Grade 125% of vertebral body has slipped forward
Grade 2 50%
Grade 3 75%
Grade 4 100%
Grade 5Vertebral body completely fallen off (i.e. spondyloptosis)
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Predictor Variables – Rule Out
Discogenic Low Back Pain
A. 3 or More Levels of DDD Likely to be Symptomatic
B. Pfirrmann Grade DDD of 1-2 or 7-8C. Modic Grade III Changes D. Disc Extrusions or SequestrationE. Neural Compression due to Spinal StenosisF. Spondylolisthesis of Grade 2 or HigherG. Lumbar SpondylitisH. Spinal Deformity with Cobb Angle Greater
than 15 DegreesI. Any Fracture at Incident Level
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Inflammation/Infection - Spondylodiscitis
Spondylitis – Infection of the spine
Discitis – Infection of the intervertebral disc
Spondylodiscitis – Both osseous structures &
intervertebral discs are affected
Lumbar Spondylitis
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Predictor Variables – Rule Out
Discogenic Low Back Pain
A. 3 or More Levels of DDD Likely to be Symptomatic
B. Pfirrmann Grade DDD of 1-2 or 7-8C. Modic Grade III Changes D. Disc Extrusions or SequestrationE. Neural Compression due to Spinal StenosisF. Spondylolisthesis of Grade 2 or HigherG. Lumbar SpondylitisH. Spinal Deformity with Cobb Angle Greater
than 15 DegreesI. Any Fracture at Incident Level
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Cobb Angles >15° are excluded
Spinal Deformity with Cobb Angle Greater than 15 Degrees Rule Out
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Predictor Variables – Rule Out
Discogenic Low Back Pain
A. 3 or More Levels of DDD Likely to be Symptomatic
B. Pfirrmann Grade DDD of 1-2 or 7-8C. Modic Grade III Changes D. Disc Extrusions or SequestrationE. Neural Compression due to Spinal StenosisF. Spondylolisthesis of Grade 2 or HigherG. Lumbar SpondylitisH. Spinal Deformity with Cobb Angle Greater
than 15 DegreesI. Any Fracture at Incident Level
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Discogenic Low Back PainImaging & Clinical Criteria
Douglas P. Beall, M.D.
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Pfirrmann Grade DDD of 3-6
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Modified Pfirrmann Scores1
GradeSignal from Nucleus and Inner Fibers
and Annulus
Distinction Between Inner and Outer Fibers of Annulus at Posterior Aspect of Disc
Height of Disc
IUniformly hyperintense,
equal to CSF Distinct Normal
IIHyperintense
(>presacral fat and <CSF) ± hypointense intranuclear cleft
Distinct Normal
IIIHyperintense
though < presacral fatDistinct Normal
IVMildly hyperintense
(slightly > outer fibers of annulus)Indistinct Normal
VHypointense
(= outer fibers of annulus)Indistinct Normal
VI Hypointense Indistinct < 30% reduction
VII Hypointense Indistinct 30 - 60% reduction
VIII Hypointense Indistinct > 60% reduction
1. 1. Score determined based upon highest score of the three categories evaluated
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Modified Pfirrmann Grading Adaptation
Modified Pfirrmann scoring based upon worst grade for 3 categories evaluated• Signal from Nucleus & Inner Fibers & Annulus• Distinction Between Inner & Outer Fibers of Annulus at Posterior Aspect of Disc• Height of Disc
An exception to the rule above for the L5-S1 level only• L5-S1 level can be naturally narrower than other lumbar levels• Use of worst score of the 3 categories at a naturally narrower L5-S1 level could
skew scoring to Pfirrmann Scores 7 & 8 because of the disc height• At the L5-S1 level only, height is only considered for categorization if the nucleus
is hypointense and there is no distinction between inner and outer fibers of the annulus at the posterior aspect of the disc
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Case Studies:Pain Generating Discs
Douglas P. Beall, MD
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Sagittal STIR Sequence
Case 1
2 Level DDD but L5-S1 is more severe in this caseModic 1 or 2 changes more likely to be assoc w/ LBPSTIR Sequence more sensitive to fluid differences w/in discsAt L5-S1 look for abnormal signal within nucleus pulposus first then judge disc height (disc normally shorter at L5-S1)
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Case 1
If in doubt, inject anesthetic & record provocative response AND the anesthetic response (how much pain goes away)
If the pain is concordant w/ injection or is gone or nearly gone later after injection of 1-2cc of anesthetic this indicates a pain generating disc
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Confidential and proprietary. For internal VIVEX use only. May not be used, copied, or distributed without consent.
Case 2
2 Level DDD w/ borderline Pfirrmann grade 6 disc at L4-5Looks ~ same height as L5-S1 disc but 5-1 disc most often shorter even when normalAxial LBP usually either facet or disc related
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