June 2-4, 2006

Weill Cornell Symposium on the Science of Dermatology

STRESSand the

SKINWeill Medical College of Cornell University

Uris Auditorium1300 York Avenue @ 69th Street

New York, NY

New York City

Sponsor

Dear Colleagues:

It has long been believed that stress and psychologic status can influence many disorders, includingdiseases of the skin. For example, it is commonly believed that such disorders as acne, psoriasis and atopicdermatitis worsen with stress.

Recent work has uncovered anatomic, physiologic and functional relationships amongst cells, organs andtissues that support the possibility that the nervous system and psychologic state can influence cutaneousimmunity. In this regard, it has been demonstrated that cells important to the immune system, includingLangerhans cells and mast cells, are anatomically associated closely with nerves and that various signalsderived from nerves can influence their functions. Additionally, both peptide and non-peptide signalsderived from nerves, or that circulate through neuroendocrine mechanisms, have been shown to influenceimportant actors in the immune cascade including lymphocytes, dendritic cells and mast cells.Additionally, there is evidence that administration of nerve-derived factors in vivo can influence thedevelopment of immunity in intact animals.

Other exciting data demonstrate that stress can influence wound healing and repair of cutaneous barrierfunction after minor perturbation.

These observations demonstrate that this field, which might be termed “psychoneurocutaneous biology”, israpidly maturing. I invite you to explore this area in detail by attending a symposium on Stress and theSkin. Areas to be covered will include Stress, Neuromodulation and Cutaneous Immunity; Stress and SkinBarrier Function; Stress, Connective Tissue and Wound Healing and Stress and Skin Disorders. Twenty-sevenexperts in this area will provide lectures and attendees are invited to submit posters for presentation at themeeting. It is our hope that this symposium will allow individuals working in the area to freely exchangetheir latest data so that the field can move forward as rapidly as possible. Clinicians will also find thesymposium to be useful, educational and fascinating. The last section of the meeting will be devotedentirely to an examination of stress effects on cutaneous diseases and problems.

I anticipate that this meeting will serve as a preeminent scientific event in a venue that has much to offerthe attendee. I hope that you will accept our invitation to spend the weekend devoted the latestdevelopments in the area of stress effects on the skin while enjoying the many cultural, gastronomic andentertainment activities available in the Big Apple.

I look forward to seeing you in New York.

Sincerely,

Richard D. Granstein, M.D.Chairman, Local Organizing Committee

Department of DermatologyJoan and Sanford I. Weill MedicalCollege of Cornell University

This symposium is supported by an unrestrictededucational grant from Clinique Laboratories, LLC.

Local Organizing CommitteeRichard D. Granstein, MDJoan and Sanford I. Weill MedicalCollege of Cornell University

Margaret Altemus, M.D.Joan and Sanford I. Weill MedicalCollege of Cornell University

Register online atwww.cornelldermatology.org

Miroslav Blumenberg, Ph.DNew York UniversitySchool of Medicine

Saturday, June 3, 20057:30am - 8:00am Continental Breakfast

Stress, Neural Modulation and CutaneousImmunity II

8:00am- 8:30am Stress-induced Immune Dysfunction – Ronald Glaser, Ph.D.

8:30am - 9:00am Neuroendocrine Regulation of Cutaneous Immunity – George J. Maestroni, Ph.D.

9:00am - 9:30am Catecholamines and Langerhans Cells – Kristina Seiffert, M.D.

9:30am - 10:00am Odorants and Cutaneous Immunity– Junichi Hosoi, Ph.D.

10:00am - 10:15am Panel Discussion

Break (15 minutes)

Stress and Skin Barrier Function

10:30am - 11:00am Overview of the Skin Barrier – Miroslav Blumenberg, Ph.D.

11:00am - 11:30am Effects of Acute and Chronic Stress on Skin: Clinical Studies– Margaret Altemus, M.D.

11:30am- 12:00pm Stress Alters Epidermal Function by Increasing Endogenous Glucocorticoids

– Peter Elias, M.D.

12:00pm - 12:15pm Panel Discussion

12:30pm – 2:00pm Poster Session I w/box lunch

Stress, Connective Tissue, and WoundHealing

2:00pm – 2:30pm Overview of Wound Healing – David T. Woodley, M.D.

2:30pm – 3:00pm Stress, Wound Healing and Matrix Metalloproteinases – Janice T. Kiecolt-Glaser, Ph.D.

3:00pm – 3:30pm Experimental Models of Stress and Wound Healing – Phillip Marucha, Ph.D.

3:30pm – 4:00pm Stress and Skin Aging– Barbara Gilchrest, Ph.D.

4:00pm – 4:15pm Panel Discussion

4:15pm – 6:15pm Poster Session II w/ wine & cheese

ProgramFriday, June 2, 2005

12:30pm - 12:45pm Welcome & Introduction– Richard D. Granstein, M.D. – Mary S. Matsui, Ph.D.

12:45pm - 1:15 pm Keynote PresentationStress: What is it and How is it Mediated?– Esther M. Sternberg, M.D.

1:15pm - 1:45pm Neuroanatomy of the Skin – Dieter Metze, M.D.

Stress, Neural Modulation and Cutaneous Immunity I

1:50pm – 2:20pm Overview of Cutaneous Immunity– Kevin D. Cooper, M.D.

2:20pm – 2:50pm Nerve-derived Mediators and Cutaneous Immunity – Richard D. Granstein, M.D.

2:50pm – 3:20pm Effect of Acute Stress on Skin Mast Cell-Dependent Vascular Permeability– Theoharis Theoharides, M.D., PhD.

3:20pm - 3:50pm Alpha-MSH and the Skin – Thomas Luger, M.D.

Break (10 minutes)

4:00pm – 4:30pm Neuroreceptors and Mediators – Sonja Ständer M.D.

4:30pm – 5:00pm Neuropeptides and Dendritic Cells– Doina Ganea, Ph.D.

5:00pm- 5:30pm Stress and the Immune System– Melanie Flint, Ph.D.

5:30pm - 6:00pm Effects of Acute vs. Chronic Stress on Skin Cell-Mediated Immunity and UV-Induced Squamous Cell Carcinoma – Firdaus S. Dhabar Ph. D.

6:00pm - 6:15pm Panel Discussion

7:00pm Reception

Space is limited.Early registration is suggested.

Sunday, June 4, 20057:00am - 8:00am Continental Breakfast

Stress and Skin Disorders

8:00am – 8:30am Stress and Acne/Rosacea – Christos C. Zouboulis, Dr. med.

8:30am – 9:00am Stress and Psoriasis– Christopher Griffiths, M.D.

9:00am – 9:30am Stress and Atopic Dermatitis– Rosalind, J. Wright, M.D.

Break (15 minutes)

9:45am – 10:15am Stress and Cancer – Bert Garssen Ph.D

10:15am – 10:45 am Stress and Hair Disorders – Ralf Paus, Prof. Dr.

10:45am – 11:15am Stress and Urticaria – Madhulika A. Gupta, M.D.

11:15am – 11:45am Panel Discussion

11:45am – 12:00pm Concluding Remarks and Farewell

Program Continued...

Continuing MedicalEducation CreditThe Weill Medical College of Cornell University Stressand the Skin is recognized by the American Academy ofDermatology for 15.75 hour(s) of Category 1 CMEcredit and may be used toward the American Academyof Dermatology's Continuing Medical Education Award.

General InformationMeeting RegistrationEnclosed is a meeting registration form. The registrationfee includes a welcome reception, coffee breaks, lunch andposter sessions. Registration can be done by mail, fax orthrough the internet at www.cornelldermatology.org

For more information contact:JAH Meeting Planners International 4101 Atlantic-Brigantine Blvd., Suite 1Brigantine, NJ 08203Ph: (609) 266-2547 Fax: (609) 266-3072e-mail: jahart623@aol.com

Hotel AccommodationsWhen making your reservations, you must identifyyourself as a registrant of the STRESS and the SKINSymposium to receive the special rate. All rooms will beheld until May 1, 2006.

Beekman Tower Hotel3 Mitchell Place ( 49th & 1st Ave)New York, NY 10017(212) 355-7300 or (866) 246-2203

Studio Suite $194 per night One Bedroom Suite $209 per night Both are single/double occupancy

Helmsley Middletowne Hotel148 E 48th StreetNew York, NY 10017(212) 755-3000 or (800) 221-4982

Room rate is $170 per night, single/double occupancy

Special ServicesIf you are in the need of any special services/arrangementswith regard to dietary needs or handicapped accessibility,indicate so on the registration form.

AirfareTravelong is the official corporate travel agency for theSTRESS and the SKIN Symposium. Their travelconsultants can assist you with your airfare from aroundthe globe to New York City. Please let the representativeknow that you are traveling for the STRESS and theSKIN Symposium.

Contact us: 212.736.2166 x202 or x206 / 800.537.6043or to request a quote go to www.travelong.com

Publication ofProceedingsThe proceedings of this meeting will be published inthe Journal of Investigative Dermatology. The abstractsand speaker presentations will be of paramount interestto immunologists, dermatologists and other cliniciansand researchers.

SpeakersMargaret Altemus, M.D.New York, New York

Miroslav Blumenberg, Ph.D.New York, New York

Kevin D. Cooper, M.D.Cleveland, Ohio

Firdaus S. Dhabhar, Ph.D.Columbus, Ohio

Peter Elias, M.D.San Francisco, California

Melanie Flint, Ph.D.Pittsburgh, Pennsylvania

Doina Ganea, Ph.D.Newark, New Jersey

Bert Garssen Ph.D.Utrecht, The Netherlands

Barbara Gilchrest, Ph.D.Boston, Massachusetts

Dieter Metze, M.D.Munster, Germany

Ralf Paus, Prof. Dr.Hamburg, Germany

Kristina Seiffert, M.D.East Lansing, Michigan

Sonja Ständer, M.D.Munster, Germany

Esther M. Sternberg, M.D.Bethesda, Maryland

Theoharis Theoharides, M.D., PhD.Boston, Massachusetts

David T. Woodley, M.D.Los Angeles, California

Rosalind, J. Wright, M.D.Boston, Massachusetts

Christos C. Zouboulis, Dr. med.Berlin, Germany

Ronald Glaser, Ph.D.Columbus, Ohio

Richard D. Granstein, M.D.New York, New York

Christopher Griffiths, M.D.Manchester, United Kingdom

Madhulika A. Gupta, M.D.Ontario, Canada

Junichi Hosoi, Ph.D.Yokohama, Japan

Janice T. Kiecolt-Glaser, Ph.D.Columbus, Ohio

Thomas Luger, M.D.Munster, Germany

George J. Maestroni, Ph.D.Locarno, Switzerland

Phillip T. Marucha, D.M.D., Ph.D.Chicago, Illinois

Submission of Abstracts for PresentationYou are cordially invited to submit abstractsrelated to the Program topics. The deadline forsubmitting an abstract is March 15, 2006.Abstracts should be typed using a laser printer.A 3.5” disk or CD containing the abstractshould be provided. Please indicate on the labelthe word processing program and version used.Text should be typed within the rectangle on theabstract submission form. Indicate on theabstract form which topic most closely relates tothe content of the abstract. Please submit anoriginal and one copy of each abstractsubmitted.

All abstracts will be judged by the members ofthe Local Organizing Committee. Acceptanceletters will be mailed by April 15, 2006.

The entire abstract, including, title, author(s),affiliation, address and text must be typed single-spaced. Leave no space between the title and thebody of the abstract or between paragraphs. Theabstract should be organized as follows:

• a sentence describing the body of the study• a statement of experimental design or methods used• a summary of results, presented in sufficient detail to

support the conclusion• a statement of conclusions reached (It is not

satisfactory to state “The results will be discussed...”or “Other data will be presented...”)

All abstracts are due no later than March 15, 2006,and must be mailed to:

Richard D. Granstein, MDChairman, Department of DermatologyWeill Medical College of Cornell University1300 York Avenue, F-342New York, NY 10021

New York City in early June has average temperaturesbetween 60 - 76ºF (16 - 25ºC)

To register, please type or print all information and mail or fax form with payment to:

JAH Meeting Planners International 4101 Atlantic-Brigantine Blvd., Suite 1Brigantine, NJ 08203Ph: (609) 266-2547 Fax: (609) 266-3072e-mail: jahart623@aol.comregister online at www.cornelldermatology.org

Last/Family Name

First Name

Degree

Address

Address

City State/Province

Postal/Zip Code Country

Tel Fax

Email

Meeting Registration Form

Hotel Registration FormPlease print all information and mail or fax to:

JAH Meeting Planners International 4101 Atlantic-Brigantine Blvd., Suite 1Brigantine, NJ 08203Ph: (609) 266-2547 Fax: (609) 266-3072e-mail: jahart623@aol.com

STRESS and the SKIN on June 2-4, 2006

Last/Family Name

First Name

Degree

Address

Address

City State/Province

Postal/Zip Code Country

Tel Fax

Email

Beekman Rates: $194 Studio Suite or $209 one bedroom suiteHelmsley Middletown: $170, single/double occupancy

Date/Time of arrival

Date/Time of departure

Number of personsIf making your own reservations, you must identify yourself asa registrant of the Stress and the Skin Symposium toreceive the special rate. The reduced rate is subject toavailability, so please reserve early. All rooms will be helduntil May 1, 2006.

PaymentPayment should be made in US dollars. Please make surechecks or bank drafts payable to the New York Hilton, or payby credit card.

Check Enclosed$

Visa Mastercard American Express

Card No.

Bank

Expiration Date

Cardholder Signature

Please check here if you have special requirements. Someone will contact you.

Registration Fees

Register on or before April 30, 2006.......................$450Register after April 30, 2006...................................$575Students, Residents and Fellows..............................$190

Attendance is limited. Advance registration is recommended.

PaymentPayment should be made in US dollars. Please make sure checksor bank drafts payable to Weill Medical College, Stress and theSkin Symposium, or pay by credit card.

Check Enclosed$

Visa Mastercard American Express

Card No.

Bank

Expiration Date

Cardholder Signature