striatal intrinsic plasticity and information processing in the corticostriatal funnel
DESCRIPTION
Striatal intrinsic plasticity and information processing in the corticostriatal funnel. Cortical synchronization. Firing of striatal medium spiny neurons. +. Short-term intrinsic plasticity. Cortical requirements for striatal MS neuron firing. Cerebral cortex. Striatum. - PowerPoint PPT PresentationTRANSCRIPT
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Striatal intrinsic plasticity and information processing Striatal intrinsic plasticity and information processing in the corticostriatal funnelin the corticostriatal funnel
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Cortical synchronizationCortical synchronization
Firing of striatal medium spiny neuronsFiring of striatal medium spiny neurons
Short-term intrinsic plasticityShort-term intrinsic plasticity
+
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Cortical requirements for striatal MS neuron firingCortical requirements for striatal MS neuron firing
Cerebral cortexCerebral cortex
StriatumStriatum
Intrinsic plasticityIntrinsic plasticity
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Membrane constants of MS neurons are not constantMembrane constants of MS neurons are not constant
From Charlie Wilson
Vm
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Experimental demonstration of a Experimental demonstration of a need of cortical spatio-temporal synchronyneed of cortical spatio-temporal synchrony
DesynchronizedDesynchronized SynchronizedSynchronized
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Temporal and spatial contraction in the CS pathwayTemporal and spatial contraction in the CS pathway
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Cortical synchronization as a trigger for striatal intrinsic plasticity?Cortical synchronization as a trigger for striatal intrinsic plasticity?
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Spike-dependent increase in membrane excitabilitySpike-dependent increase in membrane excitability
A
B
C
D
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Spike-dependent facilitation of cortical inputsSpike-dependent facilitation of cortical inputs
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Effects on the corticostriatal input-output relationshipEffects on the corticostriatal input-output relationship
No change in synaptic strengthNo change in synaptic strength Decrease in spike threshold and latencyDecrease in spike threshold and latency
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Role of the striatal KRole of the striatal K++ current I current IASAS
In vitro experiments
Activation of outwardK+ current (IAs)
Properties of IIASAS
Slow recovery from inactivation
( ~ 300 ms)
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Striatal intrinsic plasticity:Striatal intrinsic plasticity:Changes in the cortical parameters effective for striatal neurons firing and
optimization of the information transfer in the corticostriatal pathway
Intrinsic plasticityIntrinsic plasticity
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Séverine Mahon Séverine Mahon (University College of London)(University College of London)
Stéphane Charpier (Stéphane Charpier (INSERM U667 Collège de France)INSERM U667 Collège de France)
Guilaume Casassus Guilaume Casassus (UMR CNRS 5091Institut François Magendie)(UMR CNRS 5091Institut François Magendie)
Christophe Mulle Christophe Mulle (UMR CNRS 5091Institut François Magendie)(UMR CNRS 5091Institut François Magendie)