structure and composition of nuclear pore complexes (npcs)
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Structure and composition of nuclear pore complexes (NPCs)
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Electron micrographs of NPCs
Gall, 1967
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Gall, 1967
Electron micrographs of NPCs
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Three-dimensional view of a nuclear pore in the double-layered nuclear envelope
Gall, 1967
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Diagram of a model cylinder with the x-, y- and z-axes
Akey & Radermacher, 1993
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Akey & Radermacher, 1993
Averaged xy slices taken from the 3D map of the NPC
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Akey & Radermacher, 1993
3D side view of the NPC surface map
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z slices taken from 3D maps of the NPCs
Akey & Radermacher, 1993
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Akey & Radermacher, 1993
Surface views of the NPC 3D map
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3D representation of the membrane-associated NPC
Akey & Radermacher, 1993
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3D structure of the NPC
Beck et al, 2004
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Cutaway view of the NPC
Beck et al, 2004
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Slices through the structure of the pore
Beck et al, 2004
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The NPC nuclear basket
Kiseleva et al, 2004
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The NPC cytoplasmic particles
Kiseleva et al, 2004
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The NPC cytoplasmic particles
Kiseleva et al, 2004
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Immuno-labelling of Nup116
Kiseleva et al, 2004
The NPC is constructed from three main parts: 1) cytoplasmic components 2) central parts3) nucleoplasmic components
The NPC has eight rotational symmetry.
The NPC is huge structure. The vertebrate NPC has about 125 nm diameter (around 20 times larger than a ribosome).
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Comparison of the peripheral and intrinsic membrane polypeptides of nuclear envelopes and microsomal
membranes
Gerace et al, 1982
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Characterization of antibodies to gp 190 and the lamins
Gerace et al, 1982
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Immunofluorescence staining of tissue culture cells with anti-gp 190 and anti-lamins A and C
Gerace et al, 1982
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Immuno-labeling of nuclei with anti-gp 190
Gerace et al, 1982
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Presence of gp 190 in diverse vertebrate species
Gerace et al, 1982
Mammalian, yeast and worm nucleoporins
Angelo & Hetzer, 2008 (Review)
Like structure, the composition of NPC is highly conserved between human and yeast.
The NPC is composed of ONLY about 30 different proteins (nucleoporins). Ribosome has 80 different protein components.
Schematic illustration of the NPC structure
Angelo & Hetzer, 2008 (Review)
Predicted composition of scaffold and central channel
Angelo & Hetzer, 2008 (Review)
Predicted composition of cytoplasmic components
Angelo & Hetzer, 2008 (Review)
Predicted composition of nuclear components
Angelo & Hetzer, 2008 (Review)
Predicted composition of transmembrane components
Angelo & Hetzer, 2008 (Review)
Predicted localization of sub-complexes and nucleoporins within the NPC
Angelo & Hetzer, 2008 (Review)
The NPC sub-complexes are divided to two categories:1) peripheral 2) central
The nuclear pore complex in turn is made of several protein sub-complexes.