structure of aggrecan aggregate. collagen fibril embedded in proteoglycan molecules
Post on 20-Dec-2015
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structure of Aggrecan aggregate
Collagen fibril embedded in proteoglycan molecules
Fibroblast surrounded by collagen fibrils
Collagen fibrils in tadpole skin
This arrangementis also found in bone and the cornea
Elastic fibers in a dog’s aorta
Each elastin protein in the network can expand and contract as a coil
Fibronectin is an extracellular protein that helps cells attach to the matrix
Connective tissue underlying the epithelium contains a variety of cells and extracellular matrix components
A model of the basal lamina
basal lamina in the cornea of a chick’s embryo
Cross Section of Kidney
Filtration is one step in urine formation
Structure of Nephrons
Inside Bowman’s Capsule
Basal Lamina plays an important role in filtration
extracellular matrix can propagate order within a tissue
Proteases bound to surface receptors are needed to crawl through basal lamina
Melanoma cells with low filamin levels crawl poorly and tend not to metastasize
Integrin is a transmembrane heterodimer
Cells can regulate the activity of their integrins
Focal Adhesion Kinase deficient fibroblasts have more focal adhesions and can not spread
Matrix dependent cell survival in embryonic development
Signaling Pathways in Cancer