study of the stability and reactivity of migrant migrant components from printing inks and...
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![Page 1: Study of the stability and reactivity of migrant migrant components from printing inks and adhesives, used in packaging materials of foodstuffs - MIGRINKT](https://reader035.vdocument.in/reader035/viewer/2022081421/5518d194550346991f8b5d0c/html5/thumbnails/1.jpg)
Study of the stability and reactivity of migrant migrant components from printing inks and adhesives, used in
packaging materials of foodstuffs - MIGRINKT.
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Overview
• Introduction• PR FAVV-AFSCA 2009/01• MIGRINKT
– Overview 6 WP– WP 1 (15th of March)
• Today
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Introduction: Migration
- Classical migration (diffusion)- Via direct contact
- Via gas phase
- Unintented presence (set-off and residues of technical aids)
GMP
food
food
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Overview
• Introduction• PR FAVV-AFSCA 2009/01• MIGRINKT
– Overview 6 WP– WP 1 (15th of March)
• Today
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PR FAVV-AFSCA 2009/01
• No harmonized legislation !!!• General list
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PR FAVV-AFSCA 2009/01 –General list of compounds used for inks and glues manufacture
Swiss Ordinance on Food Contact materials 817.023.21• 1st of April 2010• Annex 1 (List I and II of EC Plastic Directive 2002/72/EC) and
Annex 6 (List I-V) • Annex 6 lists 5 groups of substances (almost 6000 comp)
1. Monomers 2. Colorants 3. Solvents 4. Additives 5. Photoinitiators
List A: evaluated substances, sufficient toxicity data (SML based on TDIvalue)List B: “unevaluated” substances, insufficient toxicity data (10ppb or lower detection limit)
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PR FAVV-AFSCA 2009/01 –General list of compounds used for inks and glues manufacturing
• All compounds listed in the Annex 6 of the Swiss Ordinance (Lists A and B) (5760 comp in total)
• Missing substances listed in the Information letter to the Swiss Ordinance (218 compounds)
• Compounds from Plastic Directive 2002/72/EC (Annex 1 of the Swiss Ordinance) not included in the Annex 6 of the Swiss Ordinance
(65 compounds)• Compounds from FACET list not included in the Annex
6 of the Swiss Ordinance (54 compounds)
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• General list Final list 6097 399 compounds• Final list risk ranking list:
– MW– SML
PR FAVV-AFSCA 2009/01
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PR FAVV-AFSCA 2009/01 – Final list Risk ranking list
MW <
high SML
192 compounds
MW <
MW <
low SML
207 compounds
MW < median value (202 Da)
highest priority
low MW
96 compounds
high MW
96 compounds
middle priority
lowest priority
SML >median value (1 mg/kg food)
399 compounds
SML £median value (1 mg/kg food)
low MW
104 compounds
high MW
103 compounds
median value (184 Da)
median value (184 Da)
median value (202 Da)
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PR FAVV-AFSCA 2009/01 – Final list Risk ranking list
MW <
high SML
192 compounds
MW <
MW <
low SML
207 compounds
MW < median value (202 Da)
highest priority
low MW
96 compounds
high MW
96 compounds
middle priority
lowest priority
SML >median value (1 mg/kg food)
399 compounds
SML £median value (1 mg/kg food)
low MW
104 compounds
high MW
103 compounds
median value (184 Da)
median value (184 Da)
median value (202 Da)This list includes:• 27 additives• 60 monomers• 2 solvents• 5 photoinitiators• 10 compounds from Plastic Directive
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Overview
• Introduction• PR FAVV-AFSCA 2009/01• MIGRINKT
– Overview 6 WP– WP 1 (15th of March)
• Today
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MIGRINKT – overview 6WP
• WP 1: Study of literature concerning stability, reactivity and analyze methods of the most relevant migrants
• WP 2, 3 & 4: Study of stability selected migrants in water and acetic acid (WP2), ethanol (WP3) and MPPO (WP4)– Not UV-activated compounds – UV-activated compounds
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WP 2, 3 & 4 :
Not UV-activated compounds
DarkLight
100% recovery ?
10 days/40°C 24h/reflux
yesOK
no
Investigation different temperatures (20 – 60°C) and times (1 – 10 days)
DarkLight
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WP 2, 3 & 4 :
OK
UV-activated compounds
DarkLight
100% recovery ?
10 days/40°C 24h/reflux
yes
no
Investigation different temperatures (20 – 60°C) and times (1 – 10 days)
DarkLight
UV-activation No UV-activation
10 days/40°C 24h/reflux
Light Dark Light Dark
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MIGRINKT – overview 6WP
• WP 1: Study of literature concerning stability, reactivity and analyze methods of the most relevant migrants
• WP 2, 3 & 4: Study of stability selected migrants in water and acetic acid (WP2), ethanol (WP3) and MPPO (WP4)
• WP 5: Validation kinetic models with packaging film
• WP 6: General coordination and reports
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MIGRINKT – WP1Risk ranking list FAVV
MW <
high SML
192 compounds
MW <
MW <
low SML
207 compounds
MW < median value (202 Da)
highest priority
low MW
96 compounds
high MW
96 compounds
middle priority
lowest priority
SML >median value (1 mg/kg food)
399 compounds
SML £median value (1 mg/kg food)
low MW
104 compounds
high MW
103 compounds
median value (184 Da)
median value (184 Da)
median value (202 Da)
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MIGRINKT – WP1Photoinitiators
• High priority (5):Benzophenone2-methylbenzophenone3-methylbenzophenone4-methylbenzophenoneEthyl-4-(dimethylamino)benzoate• Middle priority (7):Methyl-2-benzoylbenzoate 2-Isopropyl thioxanthone 4-Isopropyl thioxanthone2-Benzyl-2-dimethylamino-4-morpholino butyrophenone2-(4-Methylbenzyl)-2-dimethylamino-1-(4-morpholinophenyl)-1-butanon2-Hydroxy-1-(4-(4-(2-hydroxy-2-methylpropionyl)benzyl)phenyl-2-methyl-2-propanone1-(4-[(4-Benzoylphenyl)thio]phenyl)-2-methyl-2-[(4-methylphenyl)sulfonyl]-1-propan-1-one
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MIGRINKT – WP1 Photoinitiators
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MIGRINKT – WP1Photoinitiators
• High priority (5):Benzophenone2-methylbenzophenone – Type II3-methylbenzophenone – Type II4-methylbenzophenone – Type IIEthyl-4-(dimethylamino)benzoate – Type I and coinitiator• Middle priority (7):Methyl-2-benzoylbenzoate – Type II2-Isopropyl thioxanthone – Type II4-Isopropyl thioxanthone – Type II2-Benzyl-2-dimethylamino-4-morpholino butyrophenone – Type I2-(4-Methylbenzyl)-2-dimethylamino-1-(4-morpholinophenyl)-1-butanon2-Hydroxy-1-(4-(4-(2-hydroxy-2-methylpropionyl)benzyl)phenyl-2-methyl-2-propanone – Type I1-(4-[(4-Benzoylphenyl)thio]phenyl)-2-methyl-2-[(4-methylphenyl)sulfonyl]-1-propan-1-one – Type I
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Overview
• Introduction• PR FAVV-AFSCA 2009/01• MIGRINKT
– Overview 6 WP– WP 1 (15th of March)
• Today: Questions
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Are any of the selected photoinitiators (still) used in ink/glue-manufacturing?
• High priority (5):Benzophenone2-methylbenzophenone – Type II3-methylbenzophenone – Type II4-methylbenzophenone – Type IIEthyl-4-(dimethylamino)benzoate – Type I and coinitiator• Middle priority (7):Methyl-2-benzoylbenzoate – Type II2-Isopropyl thioxanthone – Type II4-Isopropyl thioxanthone – Type II2-Benzyl-2-dimethylamino-4-morpholino butyrophenone – Type I2-(4-Methylbenzyl)-2-dimethylamino-1-(4-morpholinophenyl)-1-butanon2-Hydroxy-1-(4-(4-(2-hydroxy-2-methylpropionyl)benzyl)phenyl-2-methyl-2-propanone – Type I1-(4-[(4-Benzoylphenyl)thio]phenyl)-2-methyl-2-[(4-methylphenyl)sulfonyl]-1-propan-1-one – Type I
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Are any of the selected coinitiators (still) used in ink/glue-manufacturing?
• Ethyl-4-(dimethylamino)benzoate• 4,4’-bis(dimethylamino)benzophenone)
CAS: 90-93-7• 1-hydroxycyclohexyl-1-phenyl ketone
CAS: 947-19-3 • 2-ethylhexyl-4-dimethylaminobenzoate
CAS: 21245-02-3• 2-methyl-1(4-(methylthio)phenyl)-2-morpholino propan-
1-one CAS: 71868-10-5
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Solvents are used in ink/glue-manufacturing?
• Ethyl acetate?• Ethanol?
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Use of mixtures of photoinitiators?
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UV-radiation?
• Glue: 300-500nm• Ink: 365-400nm365nm?• Light intensity range: 50-5000mW/cm2 Narrow down?
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Can we retrieve pure substances which are used in industry?
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Practical questions?
• Contact?• E.g. Mixture of
– Photoinitiator– Coinitiator– Solvent concentrations?