study program 2018/2019 elective and optional...
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UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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University of Pécs Faculty of Pharmacy
PHARMACY Major
STUDY PROGRAM 2018/2019
Elective and Optional subjects
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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1st semester
OPE-BFA-T Physical Basis of Biophysics _____________________________________________________________________ 5
OPE-BO1-T Biophysics Seminars 1 __________________________________________________________________________ 7
OPE-GOM-T Poisonous Mushrooms __________________________________________________________________________ 8
OPE-HPR-T Health Promotion _____________________________________________________________________________ 10
OPE-KP1-T Basics of Chemistry 1 _________________________________________________________________________ 13
OPE-SKS-T Inorganic Chemistry Calculations ________________________________________________________________ 15
OPF-BBM-T Introduction to Biometrics ______________________________________________________________________ 17
OPF-BFM-T Problem Solving in Biometrics __________________________________________________________________ 19
OPF-DME-T Cancer is Preventable! _________________________________________________________________________ 21
OPF-FEA-T Basics of Infectious Disease Epidemiology _________________________________________________________ 23
OPF-H1A-T Medical Hungarian 1A - Communication Skills _____________________________________________________ 25
OPF-H1B-T Medical Hungarian 1B - Language Points __________________________________________________________ 27
OPF-HB1-T How to Achieve Better Grade in Organic Chemistry 1 ________________________________________________ 29
OPF-N06-T Medical Terminology _________________________________________________________________________ 31
OPF-NS1-T Nobel Prize Awarded Cell Biology I ______________________________________________________________ 33
OPF-OTT-T History of Medicine ___________________________________________________________________________ 35
2nd semester
OPE-ABI-T Applied Biometrics ___________________________________________________________________________ 38
OPE-BO2-T Biophysics Seminars 2 _________________________________________________________________________ 40
OPE-ETI-T Pharmacy Ethics _____________________________________________________________________________ 41
OPE-FKS-T Physical Chemistry Problem Solving Seminar ______________________________________________________ 42
OPE-GKT-T History of Manufacture of Medicines _____________________________________________________________ 43
OPE-JEA-T Diseases of Signal Transduction _________________________________________________________________ 45
OPE-KP2-T Basics of Chemistry 2 _________________________________________________________________________ 47
OPE-QAS-T Quantitative Analytical Chemistry Calculation ______________________________________________________ 49
OPF-BAL-T Mineral and Spa Waters, Balneology _____________________________________________________________ 51
OPF-BMK-T Methods and Experiments in Molecular Biology ____________________________________________________ 53
OPF-H2A-T Medical Hungarian 2A - Communication Skills _____________________________________________________ 54
OPF-H2B-T Medical Hungarian 2B - Language Points __________________________________________________________ 56
OPF-HB2-T How to Achieve Better Grade in Organic Chemistry 2 ________________________________________________ 58
OPF-IZM-T Molecular Basis of Muscle Function ______________________________________________________________ 60
OPF-MGY-T Medicinal Plants in the Mecsek Mountain - Field Study 1 _____________________________________________ 62
OPF-N04-T Anatomical Terminology _______________________________________________________________________ 64
OPF-NS2-T Nobel Prize Awarded Cell Biology II _____________________________________________________________ 66
OPF-PLH-T The Placebo Effect ____________________________________________________________________________ 68
OPF-VVE-T Vaccination, Anti-Vaccination Movements: Do More Harm than Good ___________________________________ 70
3rd semester
OPE-BEE-T Basics of Epidemiology ________________________________________________________________________ 72
OPE-EHS-T Hunger, Satiety and Disturbances of Body Weight Regulation __________________________________________ 74
OPE-HOS-T Hormonal Regulatory Mechanisms in Health and Disease _____________________________________________ 76
OPE-TSA-T Statistical Analysis of Thesis and Student Research Projects ___________________________________________ 78
OPE-TSS-T Medical Applications of Mass Spectrometry ________________________________________________________ 80
OPE-WMI-T Weak Molecular Interactions ____________________________________________________________________ 82
OPF-DRD-T Drug Design _________________________________________________________________________________ 85
OPF-EBK-T Food Safety and Crisis Situations ________________________________________________________________ 87
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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OPF-GMS-T Genetically Modified Organisms and Our Health ____________________________________________________ 89
OPF-H3A-T Medical Hungarian 3A - Basics of Medical Communication for Students of Pharmacy _______________________ 91
OPF-H3B-T Medical Hungarian 3B - Medical Communication in Practice for Students of Pharmacy ______________________ 93
OPF-IPM-T Innovation and Project Management from a Business Perspective _______________________________________ 95
OPF-MGE-T Molecular Gerontology ________________________________________________________________________ 97
OPF-SSG-T Histology Seminar for Pharmacy Students _________________________________________________________ 99
OPF-TG1-T Student Project Research for Students of Pharmaceutist Programme 1 ___________________________________ 101
OPF-TMB-T Molecular Biology of Tumors __________________________________________________________________ 102
4th semester
OPE-BKM-T Basic Methods of Scientific Research ____________________________________________________________ 104
OPE-EMM-T Molecular Basis of Endocrine Diseases ___________________________________________________________ 106
OPE-GMO-T Modelling the Structure and Interactions of Bioactive Molecules _______________________________________ 108
OPE-PPP-T Proteins and Peptides in Pharmacology ___________________________________________________________ 110
OPE-SME-T Spectrometric Identification of Organic Compounds ________________________________________________ 112
OPE-TIZ-T Central Regulation of Feeding and Metabolism. New Approaches ______________________________________ 114
OPF-CSU-T Miracles of Living Materials ("Realistic" Biochemistry) _____________________________________________ 116
OPF-GMI-T Gyógyszerészek a mindennapokban _____________________________________________________________ 118
OPF-H4A-T Medical Hungarian 4A - Basics of Medical Communication for Students of Pharmacy ______________________ 119
OPF-H4B-T Medical Hungarian 4B - Medical Communication in Practice for Students of Pharmacy _____________________ 121
OPF-MAS-T Instrumental Analysis - Seminar ________________________________________________________________ 123
OPF-MMR-T Nuclear Magnetic Resonance for Dummies _______________________________________________________ 124
OPF-QBI-T Quantum Biology: Quantum Phenomena in Biological Processes ______________________________________ 126
OPF-SKI-T Basics of Chemical Informatics _________________________________________________________________ 129
OPF-TG2-T Student Project Research for Students of Pharmaceutist Programme 2 ___________________________________ 131
OPF-VAA-T Iron Metabolism: from Molecular Mechanisms to Clinical Consequences ________________________________ 132
5th semester
OPE-EFA-T Ethnopharmacobotany ________________________________________________________________________ 134
OPE-GMK-T Qualitative and Quantitative Analysis of Drugs from Human Tissue ____________________________________ 136
OPE-KMS-T Seminars in Pharmaceutical Sciences - Research Perspectives _________________________________________ 138
OPE-TG3-T Student Project Research for Students of Pharmaceutist Programme 3 ___________________________________ 140
ATT5-T Physical Education 5 _________________________________________________________________________ 141
OPF-EGZ-T Egzotic Medicinal Plants ______________________________________________________________________ 142
OPF-GKG-T Gas Chromatography _________________________________________________________________________ 144
OPF-GLK-T Bioinorganic Chemistry for Pharmacy Students ____________________________________________________ 146
OPF-GMT-T Drug Metabolism and Drug Toxicity _____________________________________________________________ 148
OPF-HVS-T Synthesis of Heterocyclic Compounds and Their Application in Therapy ________________________________ 150
OPF-MME-T Molecular Medicine __________________________________________________________________________ 152
OPF-MOD-T Molecular Diagnostics ________________________________________________________________________ 154
OPF-MOT-T Molecular Therapies _________________________________________________________________________ 156
6th semester
OPE-ASZ-T The Antimicrobial Drugs and their Clinical Use ____________________________________________________ 158
OPE-GFK-T Physico-Chemical Bases of Drug Action __________________________________________________________ 160
OPE-KPR-T Chemoprevention ____________________________________________________________________________ 162
OPE-STK-T Basics of Stereochemistry _____________________________________________________________________ 164
OPE-TG4-T Student Project Research for Students of Pharmaceutist Programme 4 ___________________________________ 166
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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OPE-VFM-T Business Development and Management _________________________________________________________ 167
OPF-DTS-T The Role of Drug Transporters _________________________________________________________________ 169
OPF-EXT-T Extraction and Chromatographic Techniques in Medicinal Plant Analysis ________________________________ 172
OPF-KNH-T Drug Plants and Hallucinogenes ________________________________________________________________ 174
OPF-MMG-T Nuclear Magnetic Resonance in Drug Development _________________________________________________ 176
OPF-PNT-T Pharmaceutical Nanotechnology ________________________________________________________________ 178
OPF-SNA-T Carbon Nanostructures _______________________________________________________________________ 181
7th semester
OPE-FM2-T Data Analysis 2 _____________________________________________________________________________ 183
OPE-FMA-T Data Analysis 1 _____________________________________________________________________________ 185
OPE-SHK-T Design and Industrial Manufacture of Medicines ___________________________________________________ 187
OPE-T2F-T Pharmaceutical Biotechnology and its links to Biopharmaceuticals _____________________________________ 189
OPF-KIA-T Essential Oils and Clinical Aromatherapy _________________________________________________________ 191
OPF-XES-T The Fate of Drug ____________________________________________________________________________ 194
8th semester
OPE-FAJ-T Pain and Analgesics __________________________________________________________________________ 196
OPE-MGT-T Pharmaceutical Technology of Modified Drug Release ______________________________________________ 198
OPF-GTH-T Gene Therapy ______________________________________________________________________________ 200
OPF-IVF-T Infections and Immunity ______________________________________________________________________ 202
9th semester
OPE-GSI-T Pharmaceutical Informatics ____________________________________________________________________ 204
OPE-GST-T Special Fields of Pharmacology_________________________________________________________________ 206
OPF-SUO-T Emergency Medicine _________________________________________________________________________ 208
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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OPE-BFA-T PHYSICAL BASIS OF BIOPHYSICS
Course director: DR. EMŐKE BÓDIS, assistant professor
Department of Biophysics
2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ both semesters ▪ recommended semester: 1
Number of hours/semester: 0 lectures + 0 practices + 28 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 100 Prerequisites: none
Topic
The course addresses the chapters of physics which are necessary for a proper understanding of Biophysics (lecture and practicals).
Beyond theoretical discussions, example problems are solved.
Conditions for acceptance of the semester
Maximum 3 absence is allowed.
Mid-term exams
Making up for missed classes
There is no option.
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
Course related information can be found on the website of the Department of Biophysics (http://biofizika.aok.pte.hu).
- Recommended literature
As a base, any secondary school physics book is useful.
Lectures
Practices
Seminars
1 Mathematical basics. Scalars and vectors
2 Physical quantities and units
3 Newton's laws
4 Conservation of momentum. Collisions
5 Motion on a straight line. Kinetics
6 Motion on a straight line. Dynamics
7 Circular motion, rotation
8 Oscillations
9 Work and energy. Friction
10 The work-energy theorem. Conservation of mechanical energy
11 Hydrostatics
12 Hydrodynamics
13 First and second law of thermodynamics
14 Thermodynamic potentials
15 Electrostatics
16 Ohm's law, Kirchhoff's laws
17 Magnetostatics
18 Magnetic induction
19 Waves
20 Wave- and geometrical optics
21 Atom- and nuclear physics
22 Radioactivity
23 Radiations (radioactive, electromagnetic)
24 Electromagnetic waves
25 Radiation-matter interaction
26 Special radiation-matter interactions
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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27 Test writing
28 Test writing
Exam topics/questions
Can be found on the website of the Department of Biophysics (http://biofizika.aok.pte.hu)
The seminar strengthens physics theoretical background and provide further understanding through evaluation of exercises (calculations)
hence the written test at the end of the semester includes theoretical questions and exercises.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Szabó-Meleg Edina (MEEDAA.T.JPTE), Dr. Talián Csaba Gábor (TACRAAO.PTE), Leipoldne Víg Andrea Teréz
(VIAFAAO.PTE), Szatmári Dávid (SZDHAAT.PTE), Takács-Kollár Veronika Tünde (KOVGACT.PTE), Tóth Mónika Ágnes
(TOMIAAT.PTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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OPE-BO1-T BIOPHYSICS SEMINARS 1
Course director: DR. ZOLTÁN UJFALUSI, assistant professor
Department of Biophysics
1 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ autumn semester ▪ recommended semester: 1
Number of hours/semester: 0 lectures + 0 practices + 14 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 40 Prerequisites: OPA-FI1 parallel
Topic
The objective of the course is to advance the acquisition of knowledge and skills related to Biophysics 1. Object-oriented discussions
and problem solving sessions are organized in interactive small-group seminars.
Conditions for acceptance of the semester
Maximum of three absences.
Mid-term exams
There will be no midterm test.
Making up for missed classes
None. Based on previous agreement with the lecturer the student can attend the seminar with another group another day on the same
week.
Reading material
- Obligatory literature
- Literature developed by the Department
http://biofizika.aok.pte.hu
- Notes
Damjanovich et al (ed.): Medical Biophysics
- Recommended literature
Lectures
Practices
Seminars
1 Introduction
2 Diffusion
3 Osmosis. Fluid flow
4 Circulation. Cardiac biophysics. Protein folding
5 Resting membrane potential. Sensory receptors. Action potential
6 Vision. Hearing
7 Cytoskeleton. Motor proteins
8 Structure of striated muscle. Molecular basis of muscle function
9 Foundations of thermodynamics. Laws of thermodynamics
10 Thermodynamic potentials
11 The double nature of light. The structure of the atoms
12 Quantum numers. Spin. Molecular orbitals
13 Laser. X-ray
14 Test writing
Exam topics/questions
Can be found on the departmental website: http://biofizika.aok.pte.hu
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Futó Kinga (FUKIAAT.PTE), Dr. Huber Tamás (HUTEAB.T.JPTE), Dr. Kengyel András Miklós (KEAFACO.PTE), Dr. Szabó-
Meleg Edina (MEEDAA.T.JPTE), Szatmári Dávid (SZDHAAT.PTE), Takács-Kollár Veronika Tünde (KOVGACT.PTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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OPE-GOM-T POISONOUS MUSHROOMS
Course director: DR. LORÁND BARTHÓ, professor
Department of Pharmacology and Pharmacotherapy
2 credit ▪ midsemester grade ▪ Elective subject for the Pharmaceutical module ▪ autumn semester ▪ recommended semester: 1
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 70 Prerequisites: none
Topic
Family physicians may play an important role in the early identification and management of mushroom poisoning (MP).
This course:
- deals with the various types of MP and their symptoms;
- molecular mechanisms encountered with the effects of cytotoxic MPs
- morphological features of the most important toxic mushrooms/fungi and their edible counterparts.
Conditions for acceptance of the semester
- Attending at least 75% of the lessons, passing the oral exam
- Oral exam includes matters of poisonings, as well as recognizing the most important PMs and their edible counterparts
Mid-term exams
Making up for missed classes
Individual
Reading material
- Obligatory literature
- Literature developed by the Department
CD prepared by Prof. Barthó
Most terms will be explained in the lectures.
- Notes
- Recommended literature
http://www.rogersmushrooms.com/
Lectures
1 Introduction
Dr. Barthó Loránd
2 Introduction
Dr. Barthó Loránd
3 Amanitas, Lepiotas (parasols) and their poisonings
Dr. Barthó Loránd
4 Amanitas, Lepiotas (parasols) and their poisonings
Dr. Barthó Loránd
5 Amanitas, Lepiotas (parasols) and their poisonings
Dr. Barthó Loránd
6 Amanitas, Lepiotas (parasols) and their poisonings
Dr. Barthó Loránd
7 Other mushrooms with white spores and their p.
Dr. Barthó Loránd
8 Other mushrooms with white spores and their p.
Dr. Barthó Loránd
9 Other mushrooms with white spores and their p.
Dr. Barthó Loránd
10 Other mushrooms with white spores and their p.
Dr. Barthó Loránd
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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11 Mushrooms with pink, brown or black spores
Dr. Barthó Loránd
12 Mushrooms with pink, brown or black spores
Dr. Barthó Loránd
13 Mushrooms with pink, brown or black spores
Dr. Barthó Loránd
14 Mushrooms with pink, brown or black spores
Dr. Barthó Loránd
15 Mushrooms with pink, brown or black spores
Dr. Barthó Loránd
16 Mushrooms with pink, brown or black spores
Dr. Barthó Loránd
17 Mushrooms with tubes, pores, wrinkles or spines
Dr. Barthó Loránd
18 Mushrooms with tubes, pores, wrinkles or spines
Dr. Barthó Loránd
19 Molecular mechanisms encountered with the effects of cytotoxic MPs
Dr. Szeberényi József
20 Molecular mechanisms encountered with the effects of cytotoxic MPs
Dr. Szeberényi József
21 Morels, false morels, puff-balls, corals, etc. Pre-exam
Dr. Barthó Loránd
22 Morels, false morels, puff-balls, corals, etc.
Dr. Barthó Loránd
23 Some forensic aspects of MPs
Dr. Barthó Loránd
24 Muscarine, muscimol, ibotenic acid
Dr. Barthó Loránd
25 Coprin, orellanin, aflatoxin
Dr. Barthó Loránd
26 Reprise of poisonous mushrooms
Dr. Barthó Loránd
27 Reprise of types of poisoning; Exam
Dr. Barthó Loránd
28 Exam
Dr. Barthó Loránd
Practices
Seminars
Exam topics/questions
Oral exam including matters of poisonings, as well as recognizing the most important PMs and their edible counterparts
Cytotoxic MPs
Gastrointestinal MP
Muscarine-type of MP
Psychotropic MP
Other types of MP
Tasks of the general practitioner in case of MP
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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OPE-HPR-T HEALTH PROMOTION
Course director: DR. ISTVÁN KISS, professor
Department of Public Health Medicine
2 credit ▪ midsemester grade ▪ Elective subject for the Medical/Biological module ▪ autumn semester ▪ recommended semester: 1
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 20 Prerequisites: none
Topic
Health promotion is intimately related not only to preventive medicine, but to the everyday practice of physicians as well. A considerable
part of noninfectious diseases is preventable, morbidity and mortality of these illnesses are decreasable by the implementation of effective
intervention.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
Neptun Meet Street
Making up for missed classes
There are no make-up classes
Reading material
- Obligatory literature
- Literature developed by the Department
Education material on Neptun
- Notes
- Recommended literature
Lectures
1 Definitions of health. Relationship between health status and fields of life.
Theoretical background of health promotion.
Dr. Horváth-Sarródi Andrea
2 Definitions of health. Relationship between health status and fields of life.
Theoretical background of health promotion.
Dr. Horváth-Sarródi Andrea
3 Salutogenesis and patogenesis.
Basic documents of health proomotion.
Dr. Horváth-Sarródi Andrea
4 Salutogenesis and patogenesis.
Basic documents of health proomotion.
Dr. Horváth-Sarródi Andrea
5 Relationship between health promotion and health education. Differences in theory and methods.
Methods of health promotion.
Dr. Horváth-Sarródi Andrea
6 Relationship between health promotion and health education. Differences in theory and methods.
Methods of health promotion.
Dr. Horváth-Sarródi Andrea
7 Measuring of results in health promotion activities.
Evidence based health promotion.
Dr. Horváth-Sarródi Andrea
8 Measuring of results in health promotion activities.
Evidence based health promotion.
Dr. Horváth-Sarródi Andrea
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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9 Health promotion and health policy.
Lalonde-model. Health in all policies (HiAP).
Dr. Horváth-Sarródi Andrea
10 Health promotion and health policy.
Lalonde-model. Health in all policies (HiAP).
Dr. Horváth-Sarródi Andrea
11 Multisectorality. Stakeholders.
Health Impact Assessment (HIA) I.
Dr. Horváth-Sarródi Andrea
12 Multisectorality. Stakeholders.
Health Impact Assessment (HIA) I.
Dr. Horváth-Sarródi Andrea
13 Health Impact Assessment (HIA) II.
Health promotion in communities.
Dr. Horváth-Sarródi Andrea
14 Health Impact Assessment (HIA) II.
Health promotion in communities.
Dr. Horváth-Sarródi Andrea
15 Method of health planning.
SWOT-analysis.
Dr. Horváth-Sarródi Andrea
16 Method of health planning.
SWOT-analysis.
Dr. Horváth-Sarródi Andrea
17 Personal health planning.
Effective health promotion in settings (school).
Dr. Horváth-Sarródi Andrea
18 Personal health planning.
Effective health promotion in settings (school).
Dr. Horváth-Sarródi Andrea
19 Effective health promotion in settings(workplace).
Health Promoting Universities.
Dr. Horváth-Sarródi Andrea
20 Effective health promotion in settings(workplace).
Health Promoting Universities.
Dr. Horváth-Sarródi Andrea
21 Possibilities of application and actualities in the concept of Health Promoting Universities.
Methods of mental health promotion.
Dr. Horváth-Sarródi Andrea
22 Possibilities of application and actualities in the concept of Health Promoting Universities.
Methods of mental health promotion.
Dr. Horváth-Sarródi Andrea
23 Promotion of positive mental health and possibilities of prevention of mental disorders.
Mental health policy.
Dr. Horváth-Sarródi Andrea
24 Promotion of positive mental health and possibilities of prevention of mental disorders.
Mental health policy.
Dr. Horváth-Sarródi Andrea
25 Role of physicians in the primary, secondary and tertiary levels of prevention.
Multiplicating effect of the physicians in the society.
Dr. Horváth-Sarródi Andrea
26 Role of physicians in the primary, secondary and tertiary levels of prevention.
Multiplicating effect of the physicians in the society.
Dr. Horváth-Sarródi Andrea
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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27 Complex health promotion programs.
Examples for good practices in health promotion.
Lee Andrew
28 Complex health promotion programs.
Examples for good practices in health promotion.
Lee Andrew
Practices
Seminars
Exam topics/questions
Neptun Meet Street
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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OPE-KP1-T BASICS OF CHEMISTRY 1
Course director: DR. PÁL PERJÉSI, professor
Department of Pharmaceutical Chemistry
2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ autumn semester ▪ recommended semester: 1
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 50 Prerequisites: none
Topic
Based on the previously acquired high school knowledge the course provides an overview on the basic laws of Chemistry concentrating
on those that are ubiquitous in the chemistry-related subjects of the basic modules of the health related curriculums. The course helps
understanding the chemistry-related compulsory subjects of the modules.
Conditions for acceptance of the semester
Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation in the lectures is obligatory.
Maximum three absences can be accepted both from lectures and practices. Two midterm tests will be written during the semester on the
7th and the 12th weeks. The result of both tests should be above 60%. One re-take chance is allowed after both tests.
Mid-term exams
Making up for missed classes
There is no opportunity to make up missed classes.
Reading material
- Obligatory literature
Ebbing D.D., Gammon S.D.: General Chemistry, Houghton Miffilin Co., Boston, 2009
- Literature developed by the Department
Almási A., Kuzma M., Perjési P.: General and Inorganic Chemistry - Laboratory Techniques and Practices, electronic educational
material, University of Pécs, 2014
- Notes
- Recommended literature
en.wikibooks.org/wiki/General_Chemistry
Lectures
1 The electronic structure of atom. Elements.
Dr. Perjési Pál
2 The electronic structure of atom. Elements.
Dr. Perjési Pál
3 Chemical bonds. Geometry of molecules.
Dr. Perjési Pál
4 Chemical bonds. Geometry of molecules.
Dr. Perjési Pál
5 Kinetic theory of gases. Gas laws.
Dr. Perjési Pál
6 Kinetic theory of gases. Gas laws.
Dr. Perjési Pál
7 Liquids and solutions. Concentrations.
Dr. Perjési Pál
8 Liquids and solutions. Concentrations.
Dr. Perjési Pál
9 Colligative properties.
Dr. Perjési Pál
10 Colligative properties.
Dr. Perjési Pál
11 Chemical thermodynamics I.
Dr. Perjési Pál
12 Chemical thermodynamics I.
Dr. Perjési Pál
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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13 Chemical kinetics.
Dr. Perjési Pál
14 Chemical kinetics.
Dr. Perjési Pál
15 Chemical equilibrium I. Homogeneous equilibria.
Dr. Perjési Pál
16 Chemical equilibrium I. Homogeneous equilibria.
Dr. Perjési Pál
17 Chemical equilibrium II. Acid-base equilibriums in solution.
Dr. Perjési Pál
18 Chemical equilibrium II. Acid-base equilibriums in solution.
Dr. Perjési Pál
19 Chemical equilibrium III. Heterogeneous equilibria.
Dr. Perjési Pál
20 Chemical equilibrium III. Heterogeneous equilibria.
Dr. Perjési Pál
21 Chemical equilibrium IV. Chemical thermodynamics II.
Dr. Perjési Pál
22 Chemical equilibrium IV. Chemical thermodynamics II.
Dr. Perjési Pál
23 Electrochemistry I. Conductivity of electrolytes.
Dr. Perjési Pál
24 Electrochemistry I. Conductivity of electrolytes.
Dr. Perjési Pál
25 Electrochemistry II. Electrode potential. Galvanic cells.
Dr. Perjési Pál
26 Electrochemistry II. Electrode potential. Galvanic cells.
Dr. Perjési Pál
27 Electrochemistry III. Electrolysis.
Dr. Perjési Pál
28 Electrochemistry III. Electrolysis.
Dr. Perjési Pál
Practices
Seminars
Exam topics/questions
Written tests covering the topics of the lectures.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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OPE-SKS-T INORGANIC CHEMISTRY CALCULATIONS
Course director: DR. BEÁTA LEMLI, assistant professor
Department of Pharmaceutical Chemistry
2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ autumn semester ▪ recommended semester: 1
Number of hours/semester: 0 lectures + 0 practices + 28 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 70 Prerequisites: none
Topic
This subject is based on the acquired theoretical knowledge on General and Inorganic Chemistry, with adaptation of the principles to
solve chemical problems. The aim of this course to solve chemical calculations related to the lessons of General and Inorganic Chemistry
1 and give a support for easier understanding of the subject.
Conditions for acceptance of the semester
According to the Code of Studies and Examinations (see on the homepage). During the semester maximum 3 missed classes are
acceptable. Two midterm tests will be written during the semester on the 7th and the 12th weeks. The result of both tests should be above
60%. One re-take chance is allowed after both tests.
Mid-term exams
Two written exams during the semester.
Making up for missed classes
There is no opportunity to make up missed classes.
Reading material
- Obligatory literature
Ebbing D.D., Gammon S.D.: General Chemistry, Houghton Miffilin Co., Boston, 2009.
- Literature developed by the Department
Almási A., Kuzma M., Perjési P.: General and Inorganic Chemistry - Laboratory Techniques and Calculations, electronic educational
material, University of Pécs, 2014
- Notes
- Recommended literature
en.wikibooks.org/wiki/General_Chemistry
Lectures
Practices
Seminars
1 Introduction to the calculations on inorganic chemistry (basis of chemistry). Stochiometric calculations.
2 Introduction to the calculations on inorganic chemistry (basis of chemistry). Stochiometric calculations.
3 Stochiometric calculations. Calculation of concentrations.
4 Stochiometric calculations. Calculation of concentrations.
5 Calculation of concentrations, Solubility.
6 Calculation of concentrations, Solubility.
7 Electrolytic dissociation.
8 Electrolytic dissociation.
9 Kolligative properites.
10 Kolligative properites.
11 Thermochemistry (Hess’ Law).
12 Thermochemistry (Hess’ Law).
13 Chemical kinetics. Test 1
14 Chemical kinetics. Test 1
15 pH calculations I.: Hydrolysis of salts.
16 pH calculations I.: Hydrolysis of salts.
17 pH calculations II: Buffers.
18 pH calculations II: Buffers.
19 Solubility equilibria.
20 Solubility equilibria.
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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21 Calculations based on the balancing of redox equations I
22 Calculations based on the balancing of redox equations I
23 Calculations based on the balancing of redox equations II
24 Calculations based on the balancing of redox equations II
25 Calculations on electrochemistry I. Test 2
26 Calculations on electrochemistry I. Test 2
27 Calculations on electrochemistry II
28 Calculations on electrochemistry II
Exam topics/questions
The final grade is established based on the average of each written exams.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Kulcsár Győző Kornél (KUGDAA.T.JPTE), Dr. Lemli Beáta (LEBGAAF.PTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
17
OPF-BBM-T INTRODUCTION TO BIOMETRICS
Course director: DR. LÁSZLÓ PÓTÓ, associate professor
Institute of Bioanalysis
1 credit ▪ midsemester grade ▪ Optional subject ▪ both semesters ▪ recommended semester: 1
Number of hours/semester: 0 lectures + 14 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 1 – 20 Prerequisites: none
Topic
Exploring data (using graphs and numbers) are usually handled as one-lesson ‘first chapter’ by basic statistical courses. This is, because
a first course in statistics introduces many new skills. It also introduces some new ideas, that all are ‘hard to understand’ for students.
The new approach is to make a solid foundation to learn statistics by a more thorough introduction to those: The course tries to make
clear a few of these fundamental ideas of statistics - limited to understanding and working with data. An improved skill for exploring
data is useful not only at your classes and your future job but in the everyday life as well.
Conditions for acceptance of the semester
Maximum one missed class.
Mid-term exams
Active participation at the classes.
Making up for missed classes
One extra class
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
László Pótó: Biometrics, workbook, Pécs, 2018
- Recommended literature
1, Moore, D. S.: The Basic Practice of Statistics, 7th edition, 2015
2, Moore, David S., McCabe, George P.: Introduction to the Practice of Statistics, 5th edition, W.H. Freeman, 2005
and
Yates, Dan, Moore, David S., Starnes, Daren S.: The Practice of Statistics (TI-83/89 Graphing Calculator Enhanced) 2/e, W.H.
Freeman, 2003 or
3, Rees, W. G.: Essential Statistics, Chapman and Hall, 1992
Lectures
Practices
1 Probability examples 1
2 Probability examples 1
3 Probability examples 2 - discrete distributions
4 Probability examples 2 - discrete distributions
5 Exploring data by graphs - 1
6 Exploring data by graphs - 1
7 Exploring data by graphs - 2
8 Exploring data by graphs - 2
9 Exploring data by numbers - sample measures 1
10 Exploring data by numbers - sample measures 1
11 Exploring data by numbers - sample measures 2
12 Exploring data by numbers - sample measures 2
13 The normal distribution
14 The normal distribution
Seminars
Exam topics/questions
No exam - but active participation on the classes is a must.
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
18
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Pótó László (POLGABO.PTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
19
OPF-BFM-T PROBLEM SOLVING IN BIOMETRICS
Course director: DR. LÁSZLÓ PÓTÓ, associate professor
Institute of Bioanalysis
1 credit ▪ midsemester grade ▪ Optional subject ▪ both semesters ▪ recommended semester: 1
Number of hours/semester: 0 lectures + 14 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 1 – 20 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
Give a chance to have more practice to solve problems in Biometrics using PC and the SPSS software in the computer room. This was a
regular need of the students earlier since the special way how a MD should handle the typical medical problems (special way of thinking)
was not founded by the secondary school education. This foundation is an important focus point of the Biometrics course. It seems, the
weekly 1+1 lectures were not enough for most of the students for completing this important goal: To develop some brand new skills.
This course offers an organized way for that extra practices. It offers also some ‘brushing up’ chances for those who has completed
Biometrics earlier.
Conditions for acceptance of the semester
Maximum one missed class
Mid-term exams
Active participation on the classes.
Making up for missed classes
One extra class
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
László Pótó: Biometrics, workbook, Pécs, 2018.
- Recommended literature
1, Moore, D. S.: The Basic Practice of Statistics, 7th edition, 2015.
or
2, Moore, David S., McCabe, George P.: Introduction to the Practice of Statistics, 5th edition, W.H. Freeman, 2005
and
Yates, Dan, Moore, David S., Starnes, Daren S.: The Practice of Statistics (TI-83/89 Graphing Calculator Enhanced) 2/e, W.H.
Freeman, 2003 or
3, Rees, W. G.: Essential Statistics, Chapman and Hall, 1992
Lectures
Practices
1 The Confidence Interval of the expected value
2 The Confidence Interval of the expected value
3 The one sample (and the paired samples) t test
4 The one sample (and the paired samples) t test
5 The CI and the hypothesis testing - the type one and type two errors.
6 The CI and the hypothesis testing - the type one and type two errors. MDM basics 1.
7 The independent samples t test
8 The independent samples t test
9 The linear regression
10 The linear regression
11 The contingency tables - the chi squares test
12 The contingency tables - the chi squares test
13 The nonparametric tests
14 The nonparametric tests. MDM basics 2.
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
20
Seminars
Exam topics/questions
No exam but active participation on the classes is a must.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Pótó László (POLGABO.PTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
21
OPF-DME-T CANCER IS PREVENTABLE!
Course director: DR. ISTVÁN KISS, professor
Department of Public Health Medicine
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 1
Number of hours/semester: 26 lectures + 0 practices + 2 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 30 Prerequisites: none
Topic
One of the major challenges for the health care system of the 21st century is the high number of cancer caused deaths. Over the past
decades, despite a significant development on the field of medicine, the prognosis of this disease is still not satisfactory. Thus prevention
has a key role in in the fight against cancer. The course gives a description on the different types of cancer their major risk factors for a
more detailed understanding. Methods of cancer prevention will be described and emphasized - including theoretical knowledge and a
practical guide as well. During the course the results of most recent human epidemiological studies on cancer will also be described.
Conditions for acceptance of the semester
Participation in lectures and practicals is obligatory which is registered. Absences should not exceed 4x45 min. Otherwise signature of
grade book is denied.
Mid-term exams
Making up for missed classes
There are no make-up classes.
Reading material
- Obligatory literature
- Literature developed by the Department
Educational material uploaded on Neptun.
- Notes
- Recommended literature
Robert Weinberg (ed.): The Biology of Cancer, Garland Science 2006 ISBN 0815340788
Boffetta P., La Veccia: Neoplasms 2009. In Detels R, Beaglehole R, Lansang MA and Gulliford M (eds.) Oxford Textbook of Public
Health, 5th ed., Oxfort University Press
Lectures
1 Cancer in the 21st century
Dr. Kiss István
2 Cancer in developing and developed countries
Dr. Kiss István
3 The process of carcinogenesis I
Dr. Kiss István
4 The process of carcinogenesis II
Dr. Kiss István
5 Characteristics of cancer cells
Dr. Kiss István
6 Molecular epidemiology of cancer
Dr. Kiss István
7 The most important cancer risk factors in general I
Dr. Kiss István
8 The most important cancer risk factors in general II
Dr. Kiss István
9 Lung cancer (development, risk factors, prevention) I
Dr. Kiss István
10 Lung cancer (development, risk factors, prevention) II
Dr. Kiss István
11 Colorectal cancer (development, risk factors, prevention) I
Dr. Kiss István
12 Colorectal cancer (development, risk factors, prevention) II
Dr. Kiss István
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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13 Breast cancer (development, risk factors, prevention) I
Dr. Kiss István
14 Breast cancer (development, risk factors, prevention) II
Dr. Kiss István
15 Prostate cancer (development, risk factors, prevention)
Dr. Kiss István
16 Head and neck cancer (development, risk factors, prevention)
Dr. Kiss István
17 Pancreatic cancer (development, risk factors, prevention)
Dr. Kiss István
18 Gastric cancer (development, risk factors, prevention)
Dr. Kiss István
19 Liver cancer (development, risk factors, prevention)
Dr. Kiss István
20 Cervical cancer (development, risk factors, prevention)
Dr. Kiss István
21 Ovarian cancer (development, risk factors, prevention)
Dr. Kiss István
22 Skin cancer and melanoma malignum (development, risk factors, prevention)
Dr. Kiss István
23 Leukemia (development, risk factors, prevention)
Dr. Kiss István
24 Less frequent tumors (development, risk factors, prevention)
Dr. Kiss István
25 Genetics, genomics and epigenetics in cancer prevention I
Dr. Kiss István
26 Genetics, genomics and epigenetics in cancer prevention II
Dr. Kiss István
Practices
Seminars
1 Recommendations I
2 Recommendations II
Exam topics/questions
Neptun
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Kiss István (KIIFAD.A.JPTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
23
OPF-FEA-T BASICS OF INFECTIOUS DISEASE EPIDEMIOLOGY
Course director: DR. ISTVÁN KISS, professor
Department of Public Health Medicine
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 1
Number of hours/semester: 8 lectures + 3 practices + 3 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 15 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
However the morbidity and mortality caused by infectious diseases has significantly declined in the developed countries in the last
century due to the effective prevention methods, their complete elimination is not possible, infectious diseases are still part of our
everyday life. The spread of infectious diseases could be controlled by timely identification, proper investigation and by targeted
interventions. Aim of the course is to present the special characteristics of infectious diseases, and of infectious disease epidemiology;
basics and functioning of surveillance systems, the basics and steps of an outbreak investigation, and epidemiological methods used
during the investigation.
Conditions for acceptance of the semester
The participation in the lectures, seminars, practises is obligatory (a catalogue should be signed), a maximum of 3x45 min absence is
acceptable, above the signature will be rejected.
Mid-term exams
Making up for missed classes
None
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
Heymann (ed.): Control of Communicable Diseases Manual
Mikanatha, Lynfield, Van Beneden, de Valk (eds.): Infectious Disease Surveillance
Lectures
1 Special characteristics of infectious diseases
Dr. Prantner Ida
2 Basics of infectious disease epidemiology I
Dr. Prantner Ida
3 Basics of infectious disease epidemiology II
Dr. Prantner Ida
4 Methods used in infectious disease epidemiology
Dr. Prantner Ida
5 Basic principles of surveillance
Dr. Prantner Ida
6 Infectious disease surveillance
Dr. Prantner Ida
7 Basics and steps of outbreak investigation I
Dr. Prantner Ida
8 Basics and steps of outbreak investigation II
Dr. Prantner Ida
Practices
1 Use of epidemiological knowledge in practice I (definitions, surveillance data interpretation, analysis)
2 Use of epidemiological knowledge in practice II (Data collection, analysis, graphical interpretations)
3 Use of epidemiological knowledge in practice III (analytic studies)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
24
Seminars
1 Investigation of a food-borne outbreak I
2 Investigation of a food-borne outbreak II
3 Investigation of a food-borne outbreak III
Exam topics/questions
-
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Prantner Ida (PRIFAAO.PTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
25
OPF-H1A-T MEDICAL HUNGARIAN 1A - COMMUNICATION SKILLS
Course director: DR. GÁBOR RÉBÉK-NAGY, associate professor
Department of Languages for Specific Purposes
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 1
Number of hours/semester: 0 lectures + 28 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPE-H1B parallel
Topic
To establish basic skills in reading, writing, listening and speaking Hungarian in preparation for effective medical communication.
Conditions for acceptance of the semester
Participation in class work is obligatory. In case absences exceed 25% of total class time, the course will be regarded as uncompleted. In
the case of absences up to 25% of total class time, oral examination will have to be taken
Mid-term exams
-
Making up for missed classes
To be discussed with the course tutor in each individual case.
Reading material
- Obligatory literature
- Literature developed by the Department
In-house course book: at the homepage of the institute:
http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng
- Notes
- Recommended literature
Lectures
Practices
1 Greeting people, formality and informality
2 Greeting people, formality and informality
3 Addressing people, men and women
4 Addressing people, men and women
5 Starting conversation, the elderly and children
6 Starting conversation, the elderly and children
7 Introducing, equal and unequal relations
8 Introducing, equal and unequal relations
9 Nutritional History Taking
10 Nutritional History Taking
11 Nutrients
12 Nutrients
13 Consolidation
14 Test 1
15 Health Preservation, Sports, Addictions
16 Health Preservation, Sports, Addictions
17 Writing CV, occupation, work
18 Medical Specialties, Consulting Room and Ward
19 Medical Specialties, Consulting Room and Ward
20 Telling CV, family relations
21 Introducing family
22 Introducing family
23 Describing people - Internal and external features
24 Describing people - Internal and external features
25 Health care institutions, consolidation
26 Health care institutions, consolidation
27 Test 2
28 Course Evaluation
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
26
Seminars
Exam topics/questions
Two written test papers and oral presentations
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Hegedűs Anita (HEAAAA.B.JPTE), Dr. Rébék-Nagy Gábor (REGCAC.B.JPTE), Dr. Warta Vilmos (WAVEAB.B.JPTE), Eklicsné
Dr. Lepenye Katalin (EKLAXA.B.JPTE), Hamarné Sávay Judit (HASMAAO.PTE), Hild Gabriella (MAGAAD.B.JPTE), Horváth Lilla
Anita (HOLFABP..PTE), Kurdiné Molnár Eszter (KUMPAAK.PTE), Lokodiné Szolcsányi Judit (LOSIAAB.PTE), Mészégetőné
Halmos Éva (MEHHABE.PTE), Ronczykné Berta Anikó (BEAAAI.B.JPTE), Szántóné Dr. Csongor Alexandra (CSAAAA.B.JPTE),
Tóth Ida (TOIHABE.PTE), Váradi Katalin (VAKHAAE.PTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
27
OPF-H1B-T MEDICAL HUNGARIAN 1B - LANGUAGE POINTS
Course director: DR. GÁBOR RÉBÉK-NAGY, associate professor
Department of Languages for Specific Purposes
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 1
Number of hours/semester: 0 lectures + 28 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPF-H1A parallel
Topic
Familiarizing foreign students with basic paradigms used in specific conversations.
Conditions for acceptance of the semester
Participation in class work is obligatory. In case absences exceed 25% of total class time, the course will be regarded as uncompleted. In
the case of absences up to 25% of total class time, oral examination will have to be taken
Mid-term exams
-
Making up for missed classes
Reading material
- Obligatory literature
- Literature developed by the Department
http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng
- Notes
- Recommended literature
Lectures
Practices
1 Basics of Hungarian Phonetics and Morphology
2 Basics of Hungarian Phonetics and Morphology
3 Personal Pronouns - formal and informal style
4 Personal Pronouns - formal and informal style
5 Constructing Questions - Question Words
6 Constructing Questions - Question Words
7 Numerals - Cardinal, Ordinal, Labels
8 Numerals - Cardinal, Ordinal, Labels
9 Verbs - Definite and Indefinite Conjugation
10 Verbs - Definite and Indefinite Conjugation
11 Expressing Frequency
12 Expressing Frequency
13 Test 1
14 Articles
15 Modality - necessity
16 Modality - necessity
17 Objective Case
18 Objective Case
19 Verbal prefixes
20 Verbal prefixes
21 Expressing Time
22 Expressing Time
23 Expressing Location - Trinity of Directions
24 Expressing Location- Trinity of Directions
25 Dative Case
26 Dative Case
27 Test 2
28 Course Evaluation
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
28
Seminars
Exam topics/questions
-
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Hegedűs Anita (HEAAAA.B.JPTE), Dr. Rébék-Nagy Gábor (REGCAC.B.JPTE), Dr. Warta Vilmos (WAVEAB.B.JPTE), Eklicsné
Dr. Lepenye Katalin (EKLAXA.B.JPTE), Hamarné Sávay Judit (HASMAAO.PTE), Hild Gabriella (MAGAAD.B.JPTE), Horváth Lilla
Anita (HOLFABP..PTE), Kurdiné Molnár Eszter (KUMPAAK.PTE), Lokodiné Szolcsányi Judit (LOSIAAB.PTE), Mészégetőné
Halmos Éva (MEHHABE.PTE), Molnár Annamária (MOAF-AC.B.JPTE), Ronczykné Berta Anikó (BEAAAI.B.JPTE), Szántóné Dr.
Csongor Alexandra (CSAAAA.B.JPTE), Váradi Katalin (VAKHAAE.PTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
29
OPF-HB1-T HOW TO ACHIEVE BETTER GRADE IN ORGANIC CHEMISTRY 1
Course director: DR. BALÁZS BOGNÁR, assistant professor
Department of Organic and Pharmacological Chemistry
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 1
Number of hours/semester: 0 lectures + 0 practices + 12 seminars = total of 12 hours
Course headcount limitations (min.-max.): 2 – 20 Prerequisites: OHA-V1E-T parallel
Topic
The aim of the course is to help the students to understand the important reaction mechanisms, and find the connections between the
different topics.
1. Reaction mechanisms in organic chemistry
2. Projection structures, radical substitution
3. Electrophilic addition
4. Electrophilic aromatic substitution
5. Nucleophilic substitution 1, alkyl halides
6. 1. test
7. Nucleophilic substitution 2, organometallics, alcohols, phenols, ethers.
8. Aromatic nucleophilic substitutions
9. Stereochemistry
10-11. Practice, design and synthetic pathway of complex compounds
12. 2. test
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Nincs.
Making up for missed classes
Nincs
Reading material
- Obligatory literature
- Literature developed by the Department
The worksheets will be handed on the seminar.
- Notes
- Recommended literature
Estelle K. Meislich; Herbert Meislich; Jacob Sharefkin: Schaum’s Series 3000 Solved Problems In Organic Chemistry, McGraw-
Hill, Inc., New York, 1994
T. W. Graham Solomons: Organic Chemistry, 7th edition, Wiley and Sons, New York, 2000
John McMurry, Eric Simanek: Fundamentals of Organic Chemistry, 6th edition, Thomson Brooks/Cole, Belmont, 2007
Lectures
Practices
Seminars
1 Reaction mechanisms, nucleophilic, electrophilic and radical reagents.
2 Projection structures, Fisher projection, reactions of alkanes.
3 Electrophilic addition, reactions of alkenes.
4 Electrophilic aromatic substitution, reactivity, orientation rules.
5 The two possible mechanisms of nucleophilic substitutions, synthesis and reactions of alkyl halides.
6 First test: radical, nucleophilic and electrophilic substitutions, electrophilic additions.
7 Nucleophilic substitution 2, synthesis and reactions of alcohols, phenols, ethers.
8 Aromatic nucleophilic substitutions: aryl halides, diazonium salts.
9 Stereochemistry, relative and absolute configuration.
10 First practice, design and synthetic pathways of complex compounds.
11 Second practice, design and synthetic pathways of complex compounds.
12 Second test: substitution and addition reactions, stereochemistry.
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
30
Exam topics/questions
There is no exam.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Bognár Balázs (BOBGAAT.PTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
31
OPF-N06-T MEDICAL TERMINOLOGY
Course director: GABRIELLA HÁBEL, language teacher
Department of Languages for Specific Purposes
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 1
Number of hours/semester: 14 lectures + 0 practices + 14 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 250 Prerequisites: none
Topic
Introduction into the basics of Medical Terminology pertaining to Anatomy and clinical aspects focusing on word building and breaking
down medical terms.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
Making up for missed classes
To be discussed with the instructor.
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
University Script
Donáth, Tibor: Lexicon Anatomiae. Anatomical Dictionary, Semmelweis, Bp. 1999
Barbara Janson Cohen: Medical Terminology, Wolters Kluwer, Lippincott Williams and Wilkins, Baltimore 2008
This resource is also available via thePoint (http://thepoint.lww.com/cohen5e)
Jean Tannis Dennerll: Medical Terminology Made Easy, Delmar Publishers Inc., New York 1991
Lectures
1 Introduction into Medical Terminology. The importance of Medical terminology in practice.
Hábel Gabriella
2 The human body. Technical language use pertaining to anatomy and clinical practice.
Hábel Gabriella
3 Termini and clinical references pertaining to the digestive system
Hábel Gabriella
4 Termini pertaining to the respiratory system
Hábel Gabriella
5 The heart. Terminology pertaining to cardiology.
Hábel Gabriella
6 Terminology pertaining to blood and lymphatic system
Hábel Gabriella
7 Terminology pertaining to the genito-urinary system
Hábel Gabriella
8 Anatomical and clinical references pertaining to the genital organs
Hábel Gabriella
9 Sensory perception and its terminology
Hábel Gabriella
10 Characteristics of the technical language use pertaining to the brain and nervous system
Hábel Gabriella
11 Terms pertaining to bones, muscles, joints, ligaments and the relevant traumas
Hábel Gabriella
12 Terms pertaining to dentistry. Anatomy of the teeth and clinical aspects
Hábel Gabriella
13 Comparison of anatomical and clinical language usages based on authentic examples
Hábel Gabriella
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
32
14 Test paper
Hábel Gabriella
Practices
Seminars
1 Introduction. Structure of Medical Terminology. Features of anatomical and clinical language usages.
2 Parts of the human body. Anatomical directions, plates.
3 Introduction into the terminology pertaining to the digestive system, diagnoses.
4 Characteristics of the terminology pertaining to the respiratory system. Case studies from the field of pulmonology.
5 About the heart in nutshell. Symptoms, diagnoses, procedures in the field of cardiology.
6 Basic termini and diseases pertaining to blood and lymphatic system.
7 Test paper
8 Basic termini pertaining to the genito-urinary system. Diagnostic features of nephrology and urology.
9 Anatomical designations pertaining to the genitalia. Diagnostic methods, procedures, interventions in the fields of gynaecology
and andrology.
10 Sensory perception. Diagnostic procedures, making diagnosis in the fields of dermatology, ophthalmology and
otorhinolaryngology.
11 Termini pertaining to the brain and neurology. Disorders of the brain, diagnoses in the field of neurology.
12 Bones, muscles, articulations, ligaments. Introduction into the language of traumatology
13 Termini pertaining to dentistry. Anatomical and clinical expressions pertaining to the buccal cavity.
14 Introduction into the technical language of pharmaceutics
Exam topics/questions
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Hábel Gabriella (HAGTAAP.PTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
33
OPF-NS1-T NOBEL PRIZE AWARDED CELL BIOLOGY I
Course director: DR. MARIANNA PAP, associate professor
Department of Medical Biology
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 1
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 1 – 0 Prerequisites: none
Topic
The aim of the course is to present the most important and most exciting Nobel Prize-winning molecular cell biology discoveries based
on Nobel lectures given by the winners. The background story of the awards reveals many years of research work, good ideas, good
fortune mixed with family and other personal memories. There is no single recipe for success, the road is always a bit different, and
perhaps the only common feature is the teamwork. From the presentations one might get insight of the winners’ personality as well. An
important aspect was in the selection of the topics to emphasize their significance (DNA-, RNA-structure and their synthesis, ribosome
function), their impact on current medical way of thinking (e.g. Prions) and diagnostic methods (e.g. recombinant DNA technology,
DNA sequencing), the description of their present and future medical applicability (e.g. in vitro fertilization), as well as to highlight their
potential relations to different diseases (e.g. cell cycle regulation, reprogram of differentiated cells, RNA interference, papillomaviruses,
HIV). Lectures are organized based on the topics related to the weekly schedule of the molecular cell biology course, not in chronological
order. Most of the presented discoveries and experiments are involved in the molecular cell biology course material, so hopefully their
discussion helps in the better understanding of those topics and lead to a more effective and shorter exam preparation.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
2 written tests: on week 7 and on week 14.
Making up for missed classes
Participation on Hungarian or German lectures is the only possibility to make-up missed lectures.
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
www.nobelprize.org
Lectures
1 History of Nobel prize, interesting facts
Dr. Pap Marianna
2 Structure of nucleic acids, catalytic RNA molecules
Dr. Pap Marianna
3 Structure of proteins
Dr. Pap Marianna
4 Prions
Dr. Pap Marianna
5 PCR
Dr. Pap Marianna
6 Targeted mutagenesis
Dr. Pap Marianna
7 Recombinant DNA technology
Dr. Pap Marianna
8 DNA sequencing
Dr. Pap Marianna
9 Inhibition of gene expresssion (KO mutation)
Dr. Pap Marianna
10 Inhibition of gene expresssion (RNA interference)
Dr. Pap Marianna
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
34
11 Regulation of cell cycle
Dr. Pap Marianna
12 Regulation of cell cycle
Dr. Pap Marianna
13 DNA synthesis
Dr. Pap Marianna
14 DNA repair
Dr. Pap Marianna
15 Eukariotyc RNA synthesis
Dr. Pap Marianna
16 Eukariotyc RNA synthesis
Dr. Pap Marianna
17 Splicing
Dr. Pap Marianna
18 Splicing
Dr. Pap Marianna
19 Structure and function of ribosomes
Dr. Pap Marianna
20 Role of RNA molecules in translation
Dr. Pap Marianna
21 Genetic code
Dr. Pap Marianna
22 Genetic code
Dr. Pap Marianna
23 Gene regulation
Dr. Pap Marianna
24 Gene regulation
Dr. Pap Marianna
25 Rough endoplasmic reticulum
Dr. Pap Marianna
26 Vesicular transport
Dr. Pap Marianna
27 Receptor-mediated endocytosis
Dr. Pap Marianna
28 Receptor-mediated endocytosis, Exam
Dr. Pap Marianna
Practices
Seminars
Exam topics/questions
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
35
OPF-OTT-T HISTORY OF MEDICINE
Course director: DR. CSILLA RÚZSÁS, associate professor
Department of Operational Medicine
2 credit ▪ midsemester grade ▪ Optional subject ▪ both semesters ▪ recommended semester: 1
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 80 Prerequisites: none
Topic
The purpose of the course is to give an opportunity for reviewing the progress in medicine historically, from the ancient times up to the
present époque, on the basis of cultural background. The understanding of the fact that the contemporary medicine is the result of the
efforts of several centuries will be hopefully stimulatory for the students in the professional improvement, realizing that both the
theoretical basis and healing practice are due to the devoted work of previous generations. Accordingly, the progress from healing art to
healing science will be illustrated in relation to the culture of previous centuries.
Since the students of our University come from countries of different cultures and traditions, the progress in medicine of ancient Greek
and Persian and Islamic culture are equally reviewed, besides the European medicine where English and German relations are of
outstanding importance, as reflected by the fact that in German universities, high number of weekly hours are devoted for the history of
medicine. Accordingly, the most outstanding physicians and clinical schools, playing a prominent role in the European progress will be
reviewed.
Our aim is to demonstrate that each culture represents a value which contributes to the common treasure of humanity.
Conditions for acceptance of the semester
Survey of the theoretical basis of medical practice in a historical period.
Mid-term exams
-
Making up for missed classes
-
Reading material
- Obligatory literature
- Literature developed by the Department
Summary of the content of each lecture (detailed description of authors and the main outlines of their activity promoting the medicine)
- Notes
- Recommended literature
Delano: The Story of Medicine, London
Benke J.: Az orvostudomány története - Hungarian ed. with English summary, Medicina, Bp. 2008.
Lectures
1 Archaic medicine
Dr. Rúzsás Csilla
2 Ancient Egypt, Mesopotamia, India, traditional Chinese medicine
Dr. Rúzsás Csilla
3 Medicine in Greece in the Antiquity
Dr. Rúzsás Csilla
4 The most outstanding medical schools; Hippocratic medicine
Dr. Rúzsás Csilla
5 Medicine in the Roman times. Galen.
Dr. Rúzsás Csilla
6 Byzantine leading doctors
Dr. Rúzsás Csilla
7 Early medieval medicine in Europe
Dr. Rúzsás Csilla
8 Monasteric medicine in medieval Europe
Dr. Rúzsás Csilla
9 The medicine under Islam
Dr. Rúzsás Csilla
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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10 The most outstanding physicians of Arabic-Islamic medicine
Dr. Rúzsás Csilla
11 Foundation of the universities in the Middle-Age
Dr. Rúzsás Csilla
12 Scholastic medicine
Dr. Rúzsás Csilla
13 Medicine in the Renaissance
Dr. Rúzsás Csilla
14 Vesal. Paracelsus.
Dr. Rúzsás Csilla
15 Medicine of the 17th century: the golden age of sciences
Dr. Rúzsás Csilla
16 Raise of natural sciences. Iatrophysics and iatrochemistry
Dr. Rúzsás Csilla
17 The age of the 18th century
Dr. Rúzsás Csilla
18 The age of enlightment. Progress in pathology.
Dr. Rúzsás Csilla
19 Beginnings of modern medicine in the 19th century
Dr. Rúzsás Csilla
20 Medical schools in Europe
Dr. Rúzsás Csilla
21 Specialisation in medicine in the 19th century
Dr. Rúzsás Csilla
22 New approaches and equipment in medicine of the 19th century
Dr. Rúzsás Csilla
23 Medicine in the first half of the 20th century
Dr. Rúzsás Csilla
24 Results of Nobel-Prize winners in medicine
Dr. Rúzsás Csilla
25 Main trends in medicine in the second half of the 20th century
Dr. Rúzsás Csilla
26 Molecular biological methods in modern medicine and related problems
Dr. Rúzsás Csilla
27 The history of the University of Pécs
Dr. Rúzsás Csilla
28 Relations with prominent European scientists
Dr. Rúzsás Csilla
Practices
Seminars
Exam topics/questions
Possible themes for the essays:
Characteristics of the ancient Egyptian and Mesopotamian culture.
Medicine of ancestral Chinese civilization.
Medicine of Greece in the Antiquity.
Hippocratic medicine and the Hippocratic Collection.
Post-hippocratic medicine: The school of Athens and Alexandria.
Outstanding physicians of Persian and Arabic-Islamic medicine.
Medical education in the Middle-Ages.
The main epidemies in Europe.
The most prominent physicians in the Renaissance.
Main trends in medicine of the 19th century.
Ignatz Semmelweis, the saver of the mothers.
Most important discoveries in medicine in the 20th century.
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
38
OPE-ABI-T APPLIED BIOMETRICS
Course director: DR. KORNÉLIA FARKAS-BORBÁS, assistant professor
Institute of Bioanalysis
1 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 7 lectures + 7 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 1 – 12 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
Basics of biometrical methods are indispensable to understand the scientific results, to plan own research, and to evaluate data. The main
goal of the course is to expand and deepened the basic knowledge of biometrics via solving practical problems.
Object of the course is to demonstrate different type of research with most frequently applied biometrical methods, though representative
examples or with using of the data of the participants.
Conditions for acceptance of the semester
Problem solving, oral report
Mid-term exams
Short presentation(s) on the classes by the students
Making up for missed classes
Consultation
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
Andrew F. Siegel: Statistics and Data Analysis. An introduction, John Wiley & Sons, 1988
Douglas G. Altman: Practical Statistics for Medical Research, Chapman & Hall, 1994
P. Armitage and G. Berry: Statistical Methods in Medical Research, Blackwell Science, 1994
Robert R. Sokal / F. James Rohlf: Biometry, W. H. Freeman and Company, New York, 1981
Lectures
1 Introduction to research methodology
Borbásné Dr. Farkas Kornélia
2 Refresh the bio-statistical knowledge
Borbásné Dr. Farkas Kornélia
3 Variance analysis
Borbásné Dr. Farkas Kornélia
4 Regression analysis
Borbásné Dr. Farkas Kornélia
5 Correlation analysis
Borbásné Dr. Farkas Kornélia
6 Survival analysis
Borbásné Dr. Farkas Kornélia
7 Factor analysis
Borbásné Dr. Farkas Kornélia
Practices
1 Refresh the bio-statistical knowledge using the SPSS
2 Exercises
3 Variance analysis, post-hoc tests
4 Linear and non-linear regression analysis
5 Parametric and non-parametric(rank-) correlation analysis
6 Survival analysis, Cox-regression analysis...
7 Factor analysis
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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Seminars
Exam topics/questions
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Borbásné Dr. Farkas Kornélia (FAKAAA.T.JPTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
40
OPE-BO2-T BIOPHYSICS SEMINARS 2
Course director: DR. ZOLTÁN UJFALUSI, assistant professor
Department of Biophysics
1 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 0 lectures + 0 practices + 14 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 40 Prerequisites: OPA-FI2 parallel
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The objective of the course is to advance the acquisition of knowledge and skills related to Biophysics 2. Object-oriented discussions
and problem solving sessions are organized in interactive small-group seminars.
Conditions for acceptance of the semester
Maximum of three absences.
Mid-term exams
There will be no midterm exam.
Making up for missed classes
None. After previous agreement with the lecturer the student can attend the seminar with another group another day, the same week.
Reading material
- Obligatory literature
- Literature developed by the Department
Online materials on departmental website (http://biofizika.aok.pte.hu)
- Notes
Damjanovich Sándor, Fidy Judit, Szöllősi János (eds.): Medical Biophysics, Medicina, Budapest, 2008
- Recommended literature
Lectures
Practices
Seminars
1 Radioactivity. Radioactive radiations
2 Spectrophotometry
3 Infrared and Raman spectroscopy
4 Fluorescence spectroscopy
5 Fluorescence anisotropy. FRET
6 Light microscopy, fluorescence microscopy
7 Modern microscopic methods. FRAP
8 Flow cytometry.
9 NMR
10 MRI
11 X-ray diagnostics. CT
12 Gamma-camera, SPECT, PET
13 Ultrasound
14 Test writing
Exam topics/questions
Can be found on the departmental website (http://biofizika.aok.pte.hu)
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Futó Kinga (FUKIAAT.PTE), Dr. Huber Tamás (HUTEAB.T.JPTE), Dr. Kengyel András Miklós (KEAFACO.PTE), Dr. Lukács
András Szilárd (LUATAA0.PTE), Kilián Balázsné Raics Katalin (RAKHAAT.PTE), Takács-Kollár Veronika Tünde (KOVGACT.PTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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OPE-ETI-T PHARMACY ETHICS
Course director: TIBOR SZOLCSÁNYI, assistant professor
Department of Behavioural Sciences
1 credit ▪ midsemester grade ▪ Elective subject for the Pharmaceutical module ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 0 lectures + 0 practices + 14 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 25 Prerequisites: none
Topic
The aim of the course is to help students gain sensitivity to the ethical issues connected to the pharmacy practice. During the course
students learn about the basic ethical principles governing the pharmacist-patient and the pharmacist-physician relationship. Students
also get acquainted with the dilemmas that are raised by the conflict between business and ethics in pharmacy. The most important
concerns of research ethics and some specific ethical issues, like the question of mind-enhancing drugs, are also discussed during the
course.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Written test taking place in the last class. To improve the grade, the test can be repeated two times in the first two weeks of the exam
period. Oral exam is also an option for that purpose.
Making up for missed classes
According to the Code of Studies and Examinations
Reading material
- Obligatory literature
- Literature developed by the Department
Additional materials: Neptun MeetStreet
- Notes
- Recommended literature
Robert Veatch and Amy Haddad (eds.): Case Studies in Pharmacy Ethics, 2nd edition, Oxford University Press, New York, 2008
Lectures
Practices
Seminars
1 Introduction
2 A short history of pharmacy
3 General ethical viewpoints
4 The principle of informed consent in modern health-care
5 The ethics of patient-pharmacist relationship
6 The ethics of physician-pharmacist relationship
7 The conflict between business and ethics in pharmacy
8 The placebo effect and its ethical concerns
9 Dietary supplements, performance- and mind- enhancing drugs
10 Ethical dilemmas raised by the drug therapy of mental disorders
11 Ethical issues in animal experimentation
12 Ethical issues in clinical drug trials
13 Summarizing discussion
14 Test
Exam topics/questions
-
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Szolcsányi Tibor (SZTAAJ.B.JPTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
42
OPE-FKS-T PHYSICAL CHEMISTRY PROBLEM SOLVING SEMINAR
Course director: DR. LÍVIA NAGY-ZENGŐ, senior research fellow
Faculty of Natural Sciences - Department of General and Physical Chemistry
1 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 0 lectures + 0 practices + 14 seminars = total of 14 hours
Course headcount limitations (min.-max.): 3 – 36 Prerequisites: OPA-FZ1 parallel
Topic
This is an elective course, a lecture room practice. It helps the student understanding the ways of calculating quantitative properties of
material, extent of changes and determine important physicochemical parameters. It shows the applicability of the theoretical forms, the
proper using of units in calculations. Showing the applicability of theory it supports bringing close to understanding the principles of
basic course on physical chemistry. The practice is an informal discussion following the physical chemistry I lecturing. The students
obtain problems to solve as home work. These problems are discussed during the practice. During the semester written test are given.
The evaluation is based on the scores. Students taking this course usually can solve easier the calculating problems at the physical
chemistry I course.
Conditions for acceptance of the semester
One class absence can be tolerated.
Mid-term exams
Making up for missed classes
Full solved problems will be handed over in written form for the absent student.
Reading material
- Obligatory literature
P. Atkins, J. de Paula: Physical Chemistry, 8th edition, Oxford University Press 2006, ISBN 9780198700722
- Literature developed by the Department
- Notes
- Recommended literature
P. Atkins, J. de Paula: Physical Chemistry, 8th edition, Oxford University Press 2006, ISBN 9780198700722
D. Freifelder: Physical Chemistry for Students of Biology and Chemistry, Science Books International Inc. ISBN 0 86720-002-2
Lectures
Practices
Seminars
1 The properties of gases: states of perfect gas, the gas laws, units.
2 Basic concepts in thermodynamics, expansion work, internal energy of a system. Application of the first law.
3 Calculation of enthalpy and calorimetry.
4 Calculation of formation enthalpy and the heat capacity (cp, cv).
5 Calculation of the changes in internal energy.
6 Problem solving of entropy, changing of entropy in different processes.
7 Test: the gas laws, the first law, change in internal energy of a system, the heat capacities and entropy
8 Problems of the kinetic model of gases, collision with walls and surfaces.
9 Calculation: First rate chemical reactions.
10 Calculation: First rate chemical reactions, determination of ages by reaction kinetic base.
11 Problem solving of second rate chemical reaction and enzyme reaction
12 Electrochemical calculations: Faraday’s laws, conductivity in electrolytes, Nernst equation, Galvan cells
13 Test: problems fom kinetic model of gases, reaction kinetics and Faraday’s laws.
14 Calculation of electrolysis and corrosion
Exam topics/questions
The solved problems will be handed over in written form for the students at the end of the semester.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Nagyné Dr. Zengő Lívia (NAZLAAF.PTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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OPE-GKT-T HISTORY OF MANUFACTURE OF MEDICINES
Course director: DR. SZILÁRD PÁL, assistant professor
Institute of Pharmaceutical Technology and Biopharmacy
2 credit ▪ midsemester grade ▪ Elective subject for the Pharmaceutical module ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 100 Prerequisites: none
Topic
Aim of the course is to explain the importance of the birth of Pharmaceutical Technology, introducing the manufacture of medicines
from the ancient times until the new age. Lectures will explain how first medicines were made, how the first pharmaceutical technological
equipments were created and how the mass production of drugs became more and more important. Lectures will also elaborate the birth
of famous medicines, like the quinine, aspirin, insulin and the sildenafil.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
- participation on the lectures
- accepted work reports
- accepted written assessments
Students have to write an end-semester assessment from the lectures at acceptance level of 60%.
Making up for missed classes
Students must fulfil requirements determined by the Code of Studies and Examinations. Student has make up for the missed lectures and
work reports.
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
Leon Shargel, A. B.C. Yu, Stamford: Applied Biopharmaceutics and Pharmacokinetics
Susanna Wu-Pong, Yon Rojanasakul: Biopharmaceutical Drug Design and Development, Humana Press
Gilbert S. Banker, Christopher T. Rhodes: Modern Pharmaceutics, Marcel Dekker Inc., New York- Basel
Michael J. Rathbone, Michael S. Roberts: Modified-Release Drug Delivery Technology, Informa Healthcare
Michael E. Aulton: The Design and Manufacture of Medicines, Churchill Livingstone
Lectures
1 Introduction
Dr. Pál Szilárd
2 introduction
Dr. Kása Péter
3 Ancient technologies (Egypt, Greece, Persian Empire)
Dr. Pál Szilárd
4 Ancient technologies (Egypt, Greece, Persian Empire)
Dr. Kása Péter
5 Influence of alchemy to the pharmaceutical technology
Dr. Pál Szilárd
6 Influence of alchemy to the pharmaceutical technology
Dr. Kása Péter
7 Middle ages
Dr. Pál Szilárd
8 Middle ages
Dr. Kása Péter
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
44
9 Effect of industrial revolution
Dr. Pál Szilárd
10 Effect of industrial revolution
Dr. Kása Péter
11 Development of medicines in the new age
Dr. Pál Szilárd
12 Development of medicines in the new age
Dr. Kása Péter
13 Birth of the first industrial manufacturers
Dr. Pál Szilárd
14 Birth of the first industrial manufacturers
Dr. Kása Péter
15 Evolution of community pharmacies
Dr. Pál Szilárd
16 Evolution of community pharmacies
Dr. Kása Péter
17 Drugs that changed the world
Dr. Pál Szilárd
18 Drugs that changed the world
Dr. Kása Péter
19 Invention of the quinine
Dr. Pál Szilárd
20 Invention of the aspirine
Dr. Kása Péter
21 Invention of various famous drugs
Dr. Pál Szilárd
22 Invention of the sildenafil
Dr. Kása Péter
23 Invention of the insulin
Dr. Pál Szilárd
24 Invention of the insulin
Dr. Kása Péter
25 Test
Dr. Pál Szilárd
26 Test
Dr. Kása Péter
27 Attending the Saracen Pharmacy in Pécs
Dr. Pál Szilárd
28 Attending the Saracen Pharmacy in Pécs
Dr. Kása Péter
Practices
Seminars
Exam topics/questions
Students can get the test topics in the institute or download the from website of the institute.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Kása Péter (ISWPRM), Dr. Pál Szilárd (PASMAAO.PTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
45
OPE-JEA-T DISEASES OF SIGNAL TRANSDUCTION
Course director: GYÖRGY SÉTÁLÓ DR. JR., associate professor
Department of Medical Biology
1 credit ▪ midsemester grade ▪ Elective subject for the Medical/Biological module ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPO-GL1-T completed + OPO-GL2-T parallel
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The topics of signal transduction will be discussed beyond the details of the compulsory course, Molecular cell biology 2. In 14 x 45
minutes special attention is paid to mechanisms that are relevant to diseases.
The course is recommended to those students who are especially interested in the signaling aspects of pathological processes.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Two multiple-choice test-exams, with 20-25 questions each, one halfway and another one at the end of the course.
Making up for missed classes
It is not possible to make up for missed classes.
Reading material
- Obligatory literature
- Literature developed by the Department
Lecturers using ppt will load these up onto the intranet after their class.
- Notes
- Recommended literature
Lectures
1 Introduction to the topics. Types of inter- and intracellular signaling.
Dr. Sétáló György ifj.
2 Second messengers. The cAMP-system in cholera, pertussis and anthrax.
Dr. Palkovics Tamás
3 The PKA, PKB and phospholipase C-system. Intracellular calcium. Tumor promotion and the PKC-family.
Dr. Sétáló György ifj.
4 Catalytic receptors and their pathological alterations in diseases.
Dr. Sétáló György ifj.
5 Insulin signaling and its aspects in certain types of diabetes mellitus.
Dr. Sétáló György ifj.
6 Cytokines. NFK-B and inflammation.
Dr. Mikó Éva
7 First test exam.
Dr. Sétáló György ifj.
8 Stress signaling and the consequences of too much stress. Heatshock proteins in signaling.
Dr. Bátor Judit
9 Signaling of apoptosis and its alterations in disease.
Dr. Pap Marianna
10 Cell-cell and cell-matrix connections and their pathological relevance.
Dr. Sétáló György ifj.
11 The role of steroids in signaling and in certain diseases.
Dr. Sétáló György ifj.
12 Integrin signaling and metastasis
Dr. Berta Gergely
13 Signaling in development. Malformations.
Dr. Ábrahám Hajnalka Gabriella
14 Second test exam.
Dr. Sétáló György ifj.
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
46
Practices
Seminars
Exam topics/questions
Multiple-choice test questions based on the actually presented materials of the course.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
47
OPE-KP2-T BASICS OF CHEMISTRY 2
Course director: DR. PÁL PERJÉSI, professor
Department of Pharmaceutical Chemistry
2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 50 Prerequisites: none
Topic
Based on the previously acquired high school knowledge the course provides an overview on the basic laws of Chemistry concentrating
on those that are ubiquitous in the chemistry-related subjects of the basic modules of the health related curriculums. The course helps
understanding the chemistry-related compulsory subjects of the modules.
Conditions for acceptance of the semester
Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation in the lectures is obligatory.
Maximum three absences can be accepted both from lectures and practices. Two midterm tests will be written during the semester on the
7th and the 12th weeks. The result of both tests should be above 60%. One re-take chance is allowed after both tests.
Mid-term exams
Making up for missed classes
There is no opportunity to make up missed classes.
Reading material
- Obligatory literature
Ebbing D.D., Gammon S.D.: General Chemistry, Houghton Miffilin Co., Boston, 2009
- Literature developed by the Department
Almási A., Kuzma M., Perjési P.: General and Inorganic Chemistry - Laboratory Techniques and Practices, electronic educational
material University of Pécs, 2014
- Notes
- Recommended literature
en.wikibooks.org/wiki/General_Chemistry
J. McMurray, R. C. Fay: Chemistry, 5th edition
Lectures
1 The electronic structure of atom. Periodic properties.
Dr. Perjési Pál
2 The electronic structure of atom. Periodic properties.
Dr. Perjési Pál
3 Structure of molecules. The valence bond theory
Dr. Perjési Pál
4 Structure of molecules. The valence bond theory
Dr. Perjési Pál
5 Structure of molecules. The molecular-orbital theory.
Dr. Perjési Pál
6 Structure of molecules. The molecular-orbital theory.
Dr. Perjési Pál
7 Bonding in solids
Dr. Perjési Pál
8 Bonding in solids
Dr. Perjési Pál
9 Molecular spectroscopy I. UV-VIS
Dr. Perjési Pál
10 Molecular spectroscopy I. UV-VIS
Dr. Perjési Pál
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
48
11 Carbon: structure and reactivity
Dr. Perjési Pál
12 Carbon: structure and reactivity
Dr. Perjési Pál
13 Nitrogen: structure and reactivity.
Dr. Perjési Pál
14 Nitrogen: structure and reactivity.
Dr. Perjési Pál
15 Oxygen: structure and reactivity.
Dr. Perjési Pál
16 Oxygen: structure and reactivity.
Dr. Perjési Pál
17 Transition metals: structure and reactivity
Dr. Perjési Pál
18 Transition metals: structure and reactivity
Dr. Perjési Pál
19 Coordination compounds I. Metal-ligand bonding I
Dr. Perjési Pál
20 Coordination compounds I. Metal-ligand bonding I
Dr. Perjési Pál
21 Coordination compounds II. Metal-ligand bonding II
Dr. Perjési Pál
22 Coordination compounds II. Metal-ligand bonding II
Dr. Perjési Pál
23 Coordination compounds III. Isomerism
Dr. Perjési Pál
24 Coordination compounds III. Isomerism
Dr. Perjési Pál
25 Coordination compounds IV. Stability.
Dr. Perjési Pál
26 Coordination compounds IV. Stability.
Dr. Perjési Pál
27 Basic photochemistry
Dr. Perjési Pál
28 Basic photochemistry
Dr. Perjési Pál
Practices
Seminars
Exam topics/questions
Written test covering the topics of the lectures.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
49
OPE-QAS-T QUANTITATIVE ANALYTICAL CHEMISTRY CALCULATION
Course director: DR. GYŐZŐ KORNÉL KULCSÁR, assistant professor
Department of Biochemistry and Medical Chemistry
2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 0 lectures + 0 practices + 28 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 50 Prerequisites: none
Topic
The Quantitative analytical chemistry calculation course helps students to understand the analytical (titrimetric) calculations. It makes
theoretical backgrounds more understandable.
Conditions for acceptance of the semester
According to the Code of Studies and Examinations (see on the homepage). During the semester maximum 3 missed classes are
acceptable. Two midterm tests will be written during the semester. The result of both tests should be above 60%.
Mid-term exams
Two written exams during the semester.
Making up for missed classes
Missing written exams should be made up.
Reading material
- Obligatory literature
Harris D.C.: Quantitative Chemical Analysis, 8th ed., W.H. Freeman and Co., New York, 2010
- Literature developed by the Department
Handouts.
- Notes
- Recommended literature
Lectures
Practices
Seminars
1 Introduction - Concentrations - Concentration of standard solutions.
2 Introduction - Concentrations - Concentration of standard solutions.
3 Acid-base titrations - Methods for calculating the titration results. Calculations with molarity and normality.
4 Acid-base titrations - Methods for calculating the titration results. Calculations with molarity and normality.
5 Neutralization analysis - Standardization of a titrant. Titration curve calculations.
6 Neutralization analysis - Standardization of a titrant. Titration curve calculations.
7 Calculation of pH in titration problems I. Hydrolysis of salts.
8 Calculation of pH in titration problems I. Hydrolysis of salts.
9 Calculation of pH in titration problems II. Buffers.
10 Calculation of pH in titration problems II. Buffers.
11 Non-aqueous titration calculations.
12 Non-aqueous titration calculations.
13 Complexometry - Methods for calculating the titration results.
14 Complexometry - Methods for calculating the titration results
15 Complex chemical equilibria - Calculations with the stability constants.
16 Complex chemical equilibria - Calculations with the stability constants.
17 Redox titrations II. - Calculations based on oxidimetry.
18 Redox titrations II. - Calculations based on oxidimetry.
19 Redox titrations I. - Redox titration curve calculations.
20 Redox titrations I. - Redox titration curve calculations.
21 Redox titrations I. - Calculations based on oxidimetry.
22 Redox titrations I. - Calculations based on oxidimetry.
23 Redox titrations III. - Calculations based on reductometry.
24 Redox titrations III. - Calculations based on reductometry.
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25 Precipitate formation titrations - Calculations for the solubility products.
26 Precipitate formation titrations - Calculations for the solubility products.
27 Gravimetry.
28 Gravimetry.
Exam topics/questions
The final grade is established based on the average of each written exams.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Almási Attila (ALAFAEO.PTE), Dr. Kulcsár Győző Kornél (KUGDAA.T.JPTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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OPF-BAL-T MINERAL AND SPA WATERS, BALNEOLOGY
Course director: DR. CSABA VARGA, associate professor
Department of Public Health Medicine
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 40 Prerequisites: none
Topic
The main educational task of the subject initiating to form state-of-art regarding use and application of mineral and spa waters in Hungary
and EU with special respect of the prevention.
Short description of the course: Delivering up to date hydrological, hydrogeological, physical, chemical, biological knowledge for
students of medicine and other sciences.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
-
Making up for missed classes
-
Reading material
- Obligatory literature
- Literature developed by the Department
Neptun
- Notes
- Recommended literature
Lectures
1 Hydrogeology and balneology of mineral and spa waters
Dr. Varga Csaba
2 Hydrogeology of Hungarian mineral and spa waters
Dr. Varga Csaba
3 Correlation of the geological characteristics and the chemical composition
Dr. Varga Csaba
4 Hydrology of mineral and spa waters
Dr. Varga Csaba
5 Mineral and spa waters in Hungary and Europe
Dr. Varga Csaba
6 Chemical characteristics of mineral and spa waters
Dr. Varga Csaba
7 Inorganic analytical classification
Dr. Varga Csaba
8 Presence of microelements
Dr. Varga Csaba
9 Inorganic ions, substances and complexes in the therapeutical effect
Dr. Varga Csaba
10 Organic ions, substances and complexes in the therapeutical
Dr. Varga Csaba
11 In situ water analysis
Dr. Varga Csaba
12 Inorganic analysis
Dr. Varga Csaba
13 Hygienic microbiological analysis
Dr. Varga Csaba
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14 Artificial mineral and medicinal waters
Dr. Varga Csaba
15 Peloids: genesis, chemical/physical/toxicological properties. Hungarian peloids.
Dr. Varga Csaba
16 Mineral and spa water products
Dr. Varga Csaba
17 Introduction to Balneology: objectives and history
Dr. Varga Csaba
18 Water and ions in the human body
Dr. Varga Csaba
19 External cure with spa waters, mode of action
Dr. Varga Csaba
20 Mechanic, thermal, chemical and psychic actions, Spa reaction.
Dr. Varga Csaba
21 Water types in cure
Dr. Varga Csaba
22 Application of spa waters to different diseases
Dr. Varga Csaba
23 Therapeutic applications of peloids
Dr. Varga Csaba
24 Internal use of mineral and medicinal waters. Drinking cure
Dr. Varga Csaba
25 Inhalation cure
Dr. Varga Csaba
26 Other natural cures: climate cure, physicotherapy, additional therapies
Dr. Varga Csaba
27 Exam
Dr. Varga Csaba
28 Exam
Dr. Varga Csaba
Practices
Seminars
Exam topics/questions
Neptun
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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OPF-BMK-T METHODS AND EXPERIMENTS IN MOLECULAR BIOLOGY
Course director: DR. KATALIN SIPOS, associate professor
Department of Pharmaceutical Biology
1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 0 lectures + 0 practices + 14 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 25 Prerequisites: none
Topic
We will analyze famous and interesting molecular biological experiments and examine the development and everyday importance of
methods used in molecular biology. We will pay special attention for experimental areas of pharmaceutical research. We hope the course
material will help the students to develop problemsolving thinking.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
The course will end with a written exam.
Making up for missed classes
According to personal agreement
Reading material
- Obligatory literature
- Literature developed by the Department
Scientific articles in English
- Notes
- Recommended literature
Lectures
Practices
Seminars
1 Methods to follow replication.
2 Molecular biological methods of cell cycle examinations
3 PCR
4 Array methods
5 Blotting methods
6 Labeling methods in the molecular biology
7 Gene regulation in the prokaryotes
8 Gene regulation in the eukaryotes.
9 Genetically modified animals
10 Experimental planning in pharmaceutical research I.
11 Experimental planning in pharmaceutical research II.
12 Real time PCR
13 Methods in cell culture experiments
14 Exam
Exam topics/questions
No extra exam questions. The basis of the exam is the material of the seminars.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Pandur Edina (PAEFAA.T.JPTE), Dr. Sipos Katalin (SIKMAAO.PTE), Jánosa Gergely (JAGTAAT.PTE), Pap Ramóna
(PARTAAT.PTE), Poór Viktor Soma (POVFAB.T.JPTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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OPF-H2A-T MEDICAL HUNGARIAN 2A - COMMUNICATION SKILLS
Course director: DR. GÁBOR RÉBÉK-NAGY, associate professor
Department of Languages for Specific Purposes
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 0 lectures + 28 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 2 – 25 Prerequisites: OPF-H1A completed + OPF-H2B parallel
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
This course is meant to serve as a transition between general and specific (doctor-patient) communication skills development.
Conditions for acceptance of the semester
Participation in class work is obligatory. In case absences exceed 25% of total class time, the course will be regarded as uncompleted. In
the case of absences up to 25% of total class time, oral examination will have to be taken
Mid-term exams
-
Making up for missed classes
In the case of absences up to 25% of total class time, oral examination will have to be taken.
Reading material
- Obligatory literature
- Literature developed by the Department
http://aok.pte.hu/index.php?page=egyseg&egy_id=60&nyelv=eng&menu=okt_anyag
- Notes
- Recommended literature
Lectures
Practices
1 Logical relations, comparison
2 Logical relations, comparison
3 Giving orientation, informing people
4 Giving orientation, informing people
5 Giving descriptions, requesting and providing information
6 Giving descriptions, requesting and providing information
7 Cause and consequence
8 Cause and consequence
9 Narratives
10 Narratives
11 Giving advice
12 Giving advice
13 Expressing uncertainty
14 Expressing uncertainty
15 Test 1
16 Test 1
17 Descriptions, warning
18 Descriptions, warning
19 Polite request, command and warning
20 Polite request, command and warning
21 Parts of the human body, pain, basic symptoms
22 Parts of the human body, pain, basic symptoms
23 History taking: presenting complaints, location, direction and character of pain
24 History taking: presenting complaints, location, direction and character of pain
25 Simple examinations, diagnostic procedures
26 Simple examinations, diagnostic procedures
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27 Test 2
28 Course evaluation
Seminars
Exam topics/questions
-
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Hegedűs Anita (HEAAAA.B.JPTE), Dr. Rébék-Nagy Gábor (REGCAC.B.JPTE), Dr. Warta Vilmos (WAVEAB.B.JPTE), Eklicsné
Dr. Lepenye Katalin (EKLAXA.B.JPTE), Hamarné Sávay Judit (HASMAAO.PTE), Hild Gabriella (MAGAAD.B.JPTE), Horváth Lilla
Anita (HOLFABP..PTE), Kurdiné Molnár Eszter (KUMPAAK.PTE), Lokodiné Szolcsányi Judit (LOSIAAB.PTE), Mészégetőné
Halmos Éva (MEHHABE.PTE), Nagy Gabriella (NAGMAAO.PTE), Ronczykné Berta Anikó (BEAAAI.B.JPTE), Szántóné Dr.
Csongor Alexandra (CSAAAA.B.JPTE), Váradi Katalin (VAKHAAE.PTE)
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OPF-H2B-T MEDICAL HUNGARIAN 2B - LANGUAGE POINTS
Course director: DR. GÁBOR RÉBÉK-NAGY, associate professor
Department of Languages for Specific Purposes
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 0 lectures + 28 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPF-H1B completed + OPF-H2A parallel
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
This course is meant to provide the language basis for advanced communication between doctors and patients.
Conditions for acceptance of the semester
Participation in class work is obligatory. In case absences exceed 25% of total class time, the course will be regarded as uncompleted. In
the case of absences up to 25% of total class time, oral examination will have to be taken
Mid-term exams
-
Making up for missed classes
Reading material
- Obligatory literature
- Literature developed by the Department
http://aok.pte.hu/index.php?page=egyseg&egy_id=60&nyelv=eng&menu=okt_anyag
- Notes
- Recommended literature
Lectures
Practices
1 Expressing possessing, genitive case
2 Expressing possessing, genitive case
3 Adjectives and nouns: eg. nátha-náthás, nominalization: eg köhög-köhögés
4 Adjectives and nouns: eg. nátha-náthás, nominalization: eg köhög-köhögés
5 Question words, concerning time and location and adverbs of time
6 Question words, concerning time and location and adverbs of time
7 Expressing cause, giving explanation
8 Expressing cause, giving explanation
9 Functions of past tense in medical Hungarian
10 Functions of past tense in medical Hungarian
11 Future tense, modality expressing ability and volition
12 Future tense, modality expressing ability and volition
13 Impersonalization
14 Impersonalization
15 Consolidation test 1
16 Test 1
17 Modality expressing necessity, possibility and prohibition
18 Modality expressing necessity, possibility and prohibition
19 Definite and indefinite conjugation, prefixed verbs
20 Definite and indefinite conjugation, prefixed verbs
21 Imperative forms
22 Imperative forms
23 Giving instructions to patients
24 Giving instructions to patients
25 Giving instructions to patients
26 Consolidation
27 Test 1
28 Course evaluation
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Seminars
Exam topics/questions
-
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Hegedűs Anita (HEAAAA.B.JPTE), Dr. Rébék-Nagy Gábor (REGCAC.B.JPTE), Dr. Warta Vilmos (WAVEAB.B.JPTE), Eklicsné
Dr. Lepenye Katalin (EKLAXA.B.JPTE), Hamarné Sávay Judit (HASMAAO.PTE), Hild Gabriella (MAGAAD.B.JPTE), Horváth Lilla
Anita (HOLFABP..PTE), Kurdiné Molnár Eszter (KUMPAAK.PTE), Lokodiné Szolcsányi Judit (LOSIAAB.PTE), Mészégetőné
Halmos Éva (MEHHABE.PTE), Nagy Gabriella (NAGMAAO.PTE), Ronczykné Berta Anikó (BEAAAI.B.JPTE), Szántóné Dr.
Csongor Alexandra (CSAAAA.B.JPTE), Váradi Katalin (VAKHAAE.PTE)
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OPF-HB2-T HOW TO ACHIEVE BETTER GRADE IN ORGANIC CHEMISTRY 2
Course director: DR. BALÁZS BOGNÁR, assistant professor
Department of Organic and Pharmacological Chemistry
1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 0 lectures + 0 practices + 12 seminars = total of 12 hours
Course headcount limitations (min.-max.): 2 – 20 Prerequisites: OPA-V2E-T parallel
Topic
The aim of the course is to help the students to understand the important reaction mechanisms, and find the connections between the
different topics.
1. Revision of addition and substitution reactions
2. Basicity and reactivity of amines
3-4. Reactions of carbonyl compounds, nucleophilic additions, condensations
5. Isomerisations in carbohydrates
6. 1. test
7. Acidity of carboxilyc acids
8. Reactions of carboxilyc acids and their derivatives
9. Aromatic substitutions of heteroaromatics
10-11 Summary of the most important reaction mechanisms with complex problems
12 2. test
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Nincs.
Making up for missed classes
Nincs.
Reading material
- Obligatory literature
- Literature developed by the Department
The worksheets will be granted on the seminar.
- Notes
- Recommended literature
Estelle K. Meislich; Herbert Meislich; Jacob Sharefkin: Schaum’s Series 3000 Solved Problems In Organic Chemistry, McGraw-
Hill, Inc., New York, 1994.
T. W. Graham Solomons: Organic Chemistry, 7th edition, Wiley and Sons, New York, 2000.
John McMurry, Eric Simanek: Fundamentals of Organic Chemistry, 6th edition, Thomson Brooks/Cole, Belmont, 2007.
Lectures
Practices
Seminars
1 Summary of the most important reactions from the first semester.
2 Basicity and reactivity of amines.
3 Polarity of the carbonyl bond. Reactions of carbonyl compounds, nucleophilic additions.
4 Polarity of the carbonyl bond. Reactions of carbonyl compounds, condensations.
5 Reactions of carbohydrates: oxidation, reduction, bromination.
6 First test: synthesis and reactions of amines and carbonyl compounds.
7 Acidity of carboxilyc acids, effect of electron sending or withdrawing groups.
8 Reactivity and reactions of carboxilyc acids, amides, anhydrides, esters.
9 Aromatic substitutions of heteroaromatics, reactions of five-membered and six-membered heterocycles.
10 Summary of the most important reaction mechanisms (substitutions, additions) with complex problems.
11 Summary of the most important reaction mechanisms (condensations) with complex problems.
12 Second test: carboxilic acids and their derivatives, heteroaromatics.
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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Exam topics/questions
There is no exam.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Bognár Balázs (BOBGAAT.PTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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OPF-IZM-T MOLECULAR BASIS OF MUSCLE FUNCTION
Course director: DR. DÉNES LŐRINCZY, professor
Department of Biophysics
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 1 – 36 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The structure of muscle based on light, phase contrast, polarized and electron microscopic observations. Elastic behaviour of passive and
active muscle, types of muscle contractions, muscle force-length relationship. Work done by the muscle, muscle efficiency and heat
production. Thermoelastic behaviour of muscle. Muscle models based on mechanical and structural investigations. Bioelectrical
phenomena, excitation-contraction coupling. Energetics of muscle function, structure of muscle proteins (actin, myosin etc.), analysis of
sliding model. Energetic and spectroscopic investigations in the research of molecular dynamic and thermodynamic background of
muscle function.
Conditions for acceptance of the semester
The applicants - in the case of more than one absence (up to maximum three absences in which must not be the consultation or test) -
should prepare and will be tested from the missed topics given by the instructor. In the case of more than three absences the course can
not be accepted.
Mid-term exams
Written test at the end of semester.
Making up for missed classes
The applicants - in the case of more than one absence (up to maximum three absences in which must not be the consultation or test) -
should prepare and will be tested from the missed topics given by the instructor.
Reading material
- Obligatory literature
- Literature developed by the Department
It will be announced at the beginning of the course depending on the possibilities of libraries of Biophysical Department, Faculty of
Medicine. A permanent source could be the roaming in the Internet.
- Notes
- Recommended literature
Lectures
1 The composition of muscle.
Dr. Lőrinczy Dénes
2 The sorts of muscle.
Dr. Lőrinczy Dénes
3 The structure of muscle on the basis of light, phasecontrast and polarization microscope.
Dr. Lőrinczy Dénes
4 Structure of muscle by ELMI.
Dr. Lőrinczy Dénes
5 Sorts of muscle contraction.
Dr. Lőrinczy Dénes
6 Elastic behaviour of passive and active muscle.
Dr. Lőrinczy Dénes
7 Muscle force and length relationship, Hill`s equation.
Dr. Lőrinczy Dénes
8 Work and heat production done by a muscle, efficiency of muscle function.
Dr. Lőrinczy Dénes
9 Thermoelastic behaviour of muscle.
Dr. Lőrinczy Dénes
10 Muscle models proposed by mechanical and structural investigations.
Dr. Lőrinczy Dénes
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61
11 Biochemical basis and energetics of muscle function.
Dr. Lőrinczy Dénes
12 Bioelectrical phenomena. Action potentials.
Dr. Lőrinczy Dénes
13 Nernst equation, G-H-K equation.
Dr. Lőrinczy Dénes
14 Voltage- and patch-clamp techniques.
Dr. Lőrinczy Dénes
15 Excitation-contraction coupling.
Dr. Lőrinczy Dénes
16 Structure of muscle proteins (actin and myosin, actomyosin complex).
Dr. Lőrinczy Dénes
17 Discussion of sliding model in details (x-ray diffraction).
Dr. Lőrinczy Dénes
18 Molecular dynamic background of muscle contraction (EPR spectroscopy)
Dr. Lőrinczy Dénes
19 Muscle in the sport and rehabilitation (wellness).
Dr. Lőrinczy Dénes
20 Principle of differential scanning calorimetry.
Dr. Lőrinczy Dénes
21 Thermodynamic background of muscle contraction (DSC results)
Dr. Lőrinczy Dénes
22 Muscle and levers in locomotion.
Dr. Lőrinczy Dénes
23 Free consultation from the topics of course (discussion of any problem).
Dr. Lőrinczy Dénes
24 Free consultation from the topics of course (discussion of any problem).
Dr. Lőrinczy Dénes
25 Written test.
Dr. Lőrinczy Dénes
26 Written test.
Dr. Lőrinczy Dénes
27 Discussion of the test, final evaluation of the course.
Dr. Lőrinczy Dénes
28 Discussion of the test, final evaluation of the course.
Dr. Lőrinczy Dénes
Practices
Seminars
Exam topics/questions
Written test
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
62
OPF-MGY-T MEDICINAL PLANTS IN THE MECSEK MOUNTAIN - FIELD STUDY 1
Course director: DR. NÓRA PAPP, associate professor
Department of Pharmacognosy
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 12 lectures + 12 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 5 – 15 Prerequisites: none
Topic
The course includes 6x2 lectures and 3x4 practice (field work). The aim of the course is to practice the correct identification of medicinal
plants, knowledge of main morphological characters, habitat, collection place, and therapeutical use. The course gives a general overview
on the most frequent medicinal plants, protected and produced species, as well as various vegetation types in the Mecsek mountain and
its environment. In addition, the effect and relationship between abiotic factors and secondary metabolites of plants are also discussed,
which can provide recommendations for collection place and habitat of plants.
Conditions for acceptance of the semester
Maximal absences: 2 /semester.
Mid-term exams
Fulfillment of 2 tests.
Making up for missed classes
http://gytk.pte.hu/en/egyseg/oktatasianyagok/1640
http://aok.pte.hu/en/egyseg/oktatasianyagok/1640
Reading material
- Obligatory literature
- Literature developed by the Department
Lectures downloaded in Neptun.
- Notes
- Recommended literature
Lectures
1 Vegetation types of medicinal plants; ecological factors in habitats I
Dr. Papp Nóra
2 Vegetation types of medicinal plants; ecological factors in habitats I
Dr. Papp Nóra
3 Vegetation types of medicinal plants; ecological factors in habitats II
Dr. Papp Nóra
4 Vegetation types of medicinal plants; ecological factors in habitats II
Dr. Papp Nóra
5 Environmental adaptation of medicinal plants (morphology, phytochemistry); relationship between medicinal plant populations
and their environment
Dr. Papp Nóra
6 Environmental adaptation of medicinal plants (morphology, phytochemistry); relationship between medicinal plant populations
and their environment
Dr. Papp Nóra
7 Vegetation types in the Mecsek mountain I: medicinal plants in beech and karst shrub forests
Dr. Papp Nóra
8 Vegetation types in the Mecsek mountain II: medicinal plants in rock grasses, swamps and alder woods
Dr. Papp Nóra
9 Medicinal plants at road edge vegetations, planted and protected plants of the Mecsek mountain I
Dr. Papp Nóra
10 Medicinal plants at road edge vegetations, planted and protected plants of the Mecsek mountain II
Dr. Papp Nóra
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63
11 Identification of medicinal plants used Identification Handbooks, methods in field work I
Dr. Papp Nóra
12 Identification of medicinal plants used Identification Handbooks, methods in field work II
Dr. Papp Nóra
Practices
1 Identification of medicinal plants in rock grasses (Tettye)
2 Identification of medicinal plants in rock grasses (Tettye)
3 Identification of medicinal plants in rock grasses (Tettye)
4 Identification of medicinal plants in rock grasses (Tettye)
5 Identification of medicinal plants in oak forest (Dömörkapu)
6 Identification of medicinal plants in oak forest (Dömörkapu)
7 Identification of medicinal plants in oak forest (Dömörkapu)
8 Identification of medicinal plants in oak forest (Dömörkapu)
9 Identification of medicinal plants in swamp (Pellérd)
10 Identification of medicinal plants in swamp (Pellérd)
11 Identification of medicinal plants in swamp (Pellérd)
12 Identification of medicinal plants in swamp (Pellérd)
Seminars
Exam topics/questions
According to the topics of the course.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Papp Nóra (PANAAA.T.JPTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
64
OPF-N04-T ANATOMICAL TERMINOLOGY
Course director: GABRIELLA HÁBEL, language teacher
Department of Languages for Specific Purposes
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 0 lectures + 0 practices + 28 seminars = total of 28 hours
Course headcount limitations (min.-max.): 3 – 25 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The course aims to mediate the basic anatomical terms supporting the studies of Anatomy.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
Making up for missed classes
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
University Script
Donáth, Tibor: Lexicon Anatomiae. Anatomical Dictionary, Semmelweis, Bp. 1999.
Lectures
Practices
Seminars
1 Structure of anatomical terms.
2 Structure of anatomical terms.
3 Body Planes, Anatomical Directions, Surface Features of Bones
4 Body Planes, Anatomical Directions, Surface Features of Bones
5 Anatomical Terminology of the Upper Extremity, Bones, Joints
6 Anatomical Terminology of the Upper Extremity, Bones, Joints
7 Anatomical Terminology of the Scapula and Shoulder Girdle
8 Anatomical Terminology of the Scapula and Shoulder Girdle
9 Anatomical Terminology of the Lower Extremity, Bones, Joints
10 Anatomical Terminology of the Lower Extremity, Bones, Joints
11 Anatomical Terminology of the Pelvic Girdle, Bones, Joints
12 Anatomical Terminology of the Pelvic Girdle, Bones, Joints
13 Test paper 1.
14 Test paper 1.
15 Vertebrae, Sternum, Costae. Terminology of the Vertebral Column
16 Vertebrae, Sternum, Costae. Terminology of the Vertebral Column
17 Anatomical Terminology of the Muscular System
18 Anatomical Terminology of the Muscular System
19 Anatomical Terminology of the Skull. Calvaria, Internal Cranial Base
20 Anatomical Terminology of the Skull. Calvaria, Internal Cranial Base
21 Anatomical Terminology of the Skull. External Cranial Base
22 Anatomical Terminology of the Skull. External Cranial Base
23 Anatomical Terminology of the Skull. Palatine, Sphenoid, Temporal, Occipital Bones
24 Anatomical Terminology of the Skull. Palatine, Sphenoid, Temporal, Occipital Bones
25 Anatomical Terminology of the Skull. Temporomandibular Joint. Cranial Nerves
26 Anatomical Terminology of the Skull. Temporomandibular Joint. Cranial Nerves
27 Test paper 2.
28 Test paper 2.
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
65
Exam topics/questions
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Hábel Gabriella (HAGTAAP.PTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
66
OPF-NS2-T NOBEL PRIZE AWARDED CELL BIOLOGY II
Course director: DR. MARIANNA PAP, associate professor
Department of Medical Biology
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 1 – 0 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The aim of the course is to present the most important and most exciting Nobel Prize-winning molecular cell biology discoveries based
on Nobel lectures given by the winners. The background story of the awards reveals many years of research work, good ideas, good
fortune mixed with family and other personal memories. There is no single recipe for success, the road is always a bit different, and
perhaps the only common feature is the teamwork. From the presentations one might get insight of the winners’ personality as well. An
important aspect was in the selection of the topics to emphasize their significance (DNA-, RNA-structure and their synthesis, ribosome
function), their impact on current medical way of thinking (e.g. Prions) and diagnostic methods (e.g. recombinant DNA technology,
DNA sequencing), the description of their present and future medical applicability (e.g. in vitro fertilization), as well as to highlight their
potential relations to different diseases (e.g. cell cycle regulation, reprogram of differentiated cells, RNA interference, papillomaviruses,
HIV). Lectures are organized based on the topics related to the weekly schedule of the molecular cell biology course, not in chronological
order. Most of the presented discoveries and experiments are involved in the molecular cell biology course material, so hopefully their
discussion helps in the better understanding of those topics and lead to a more effective and shorter exam preparation.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
2 written tests: on week 7 and on week 14.
Making up for missed classes
Participation on Hungarian or German lectures is the only possibility to make-up missed lectures.
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
www.nobelprize.org
Lectures
1 Passive transport
Dr. Pap Marianna
2 Passive transport
Dr. Pap Marianna
3 Active transport
Dr. Pap Marianna
4 Action of hormones
Dr. Pap Marianna
5 G-proteins and their role in signal transduction
Dr. Pap Marianna
6 G-protein-coupled receptors
Dr. Pap Marianna
7 Growth factors
Dr. Pap Marianna
8 Growth factors
Dr. Pap Marianna
9 Reversible protein phosphorylation in signal transduction pathways
Dr. Pap Marianna
10 Reversible protein phosphorylation in signal transduction pathways
Dr. Pap Marianna
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11 Genetic control of early embryonic development
Dr. Pap Marianna
12 Genetic control of early embryonic development
Dr. Pap Marianna
13 Programmed cell death
Dr. Pap Marianna
14 Programmed cell death
Dr. Pap Marianna
15 DNA tumor viruses
Dr. Pap Marianna
16 DNA tumor viruses
Dr. Pap Marianna
17 RNA tumor viruses
Dr. Pap Marianna
18 RNA tumor viruses
Dr. Pap Marianna
19 Retroviral oncogenes
Dr. Pap Marianna
20 Retroviral oncogenes
Dr. Pap Marianna
21 Telomeres and telomerase activity in cancers
Dr. Pap Marianna
22 Telomeres and telomerase activity in cancers
Dr. Pap Marianna
23 Human cell- and tissue transplantation
Dr. Pap Marianna
24 Human cell- and tissue transplantation
Dr. Pap Marianna
25 In vitro fertilization
Dr. Pap Marianna
26 In vitro fertilization
Dr. Pap Marianna
27 The discovery of the green fluorescent protein and its significance in molecular biology
Dr. Pap Marianna
28 The discovery of the green fluorescent protein and its significance in molecular biology, Exam
Dr. Pap Marianna
Practices
Seminars
Exam topics/questions
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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68
OPF-PLH-T THE PLACEBO EFFECT
Course director: TIBOR SZOLCSÁNYI, assistant professor
Department of Behavioural Sciences
1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 50 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The use of placebo effect has been an inherent part of medicine for thousands of years, and in the recent decades it has become an
inevitable element of medical research due to the introduction of placebo controlled clinical trials. In spite of this fact the research
methodology to measure the effectiveness of placebo effect has been clarified only in the last 10-15 years. At the same time researches
on the neurochemical mechanisms underlying the placebo effect have gained a new impetus. Currently, therefore, we have a much greater
understanding of placebo effect in the context of evidence-based medicine than before, which raises new types of ethical questions as
well. During the course we will examine the different aspects of the phenomenon of placebo effect, and the students will gain knowledge
of the current research results on the field. The main topics of the course: the history of the use of placebo therapies, the role of placebo
effect in medical research, the psycho-social factors that are able to induce placebo effect, neurochemical mechanisms underlying the
placebo effect, the ethical implications of the use of placebo effect in medical treatments.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Written test taking place in the last class. To improve the grade, the test can be repeated two times in the first two weeks of the exam
period.
Making up for missed classes
According to the Code of Studies and Examinations.
Reading material
- Obligatory literature
Franklin G. Miller; Luna Colloca; Ted J. Kaptchuk: The Placebo Effect: Illness and Interpersonal Healing, Perspect Biol Med. 2009
; 52(4)
Damien G. Finniss; Ted J. Kaptchuk; Franklin G. Miller; Fabrizio Benedetti: Biological, Clinical and Ethical Advances of Placebo
Effects, Lancet 2010; 375; 686-695
Franklin G. Miller; Donald L. Rosenstein: The Nature and Power of the Placebo Effect, Journal of Clinical Epidemiology 59, 2006;
331-335
Fabrizio Benedetti: Mechanisms of Placebo and Placebo-Related Effects across Diseases and Treatments, Annual Review of
Pharmacology and Toxicology, Vol. 48; 2008; 33-60.
Jozien M. Bensing; William Verheul: The Silent Healer: The Role of Communication in Placebo Effects, Patient Education and
Counseling 80, 2010; 293-299
- Literature developed by the Department
Additional materials: Neptun MeetStreet
- Notes
- Recommended literature
Fabrizio Benedetti: Placebo Effect, Oxford University Press, Oxford, 2009
Lectures
Lectures
1 Introduction, definitions of placebo effect
Dr. Szolcsányi Tibor
2 The use of placebo effect in the history of medicine
Dr. Szolcsányi Tibor
3 The use of placebo effect in the context of medical research: the introduction of randomized placebo controlled clinical trials and
its consequences
Dr. Szolcsányi Tibor
4 The methodological and ethical challenges of placebo research
Dr. Szolcsányi Tibor
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5 The main forms of placebo effect (expectancy based / classical conditioning / affective modulation) and their effectiveness in
different diseases
Dr. Szolcsányi Tibor
6 The neurochemistry of placebo effect: placebo analgesia
Dr. Szolcsányi Tibor
7 The neurochemistry of placebo effect: the cardiovascular and the respiratory system, immune response and hormone secretion,
Parkinson disease
Dr. Szolcsányi Tibor
8 The neurochemistry of placebo effect: further results
Dr. Szolcsányi Tibor
9 An overview of the psycho-social factors that are able to induce placebo effect
Dr. Szolcsányi Tibor
10 The anthropological and evolutionary background of placebo effect
Dr. Szolcsányi Tibor
11 Pain management through psychological interventions and placebo analgesia
Dr. Szolcsányi Tibor
12 Ethical implications: how to enhance the placebo effect through improving the physician-patient relationship
Dr. Szolcsányi Tibor
13 Ethical implications: the possible role of complementary medicine in the enhancement of placebo effect
Dr. Szolcsányi Tibor
14 Written test
Dr. Szolcsányi Tibor
Practices
Seminars
Exam topics/questions
-
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPF-VVE-T VACCINATION, ANTI-VACCINATION MOVEMENTS: DO MORE HARM THAN GOOD
Course director: DR. KATALIN SZENDI, assistant professor
Department of Public Health Medicine
1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 12 lectures + 2 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 30 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
Vaccination belongs to one of the most successful modern health care programmes that decreased significantly the number of severe
infectious diseases. In today’s world experts are unable to compete with the media. Several delusions circulate infiltrating the public
opinion related to vaccines. The most susceptible target audience of these beliefs are the half-educated laymen who believe in the media
created pseudoscience. The activity of stubborn anti-vaccine minorities can be dangerous because that may open up new chances of the
spread of infectious diseases.
The objective of the course is to deepen the knowledge of vaccinations concerning the background, benefits, achievements and failures,
and the course also serves as a thought provoking initiation for practitioners relating to possible actions against the anti-vaccination
movements.
Conditions for acceptance of the semester
Participation in lectures and practicals is obligatory which is registered.
Absences should not exceed 15% (2x45 min). Otherwise signature of grade book is denied.
Mid-term exams
-
Making up for missed classes
There are no make-up classes.
Reading material
- Obligatory literature
- Literature developed by the Department
Educational material uploaded on Neptun.
- Notes
- Recommended literature
Stanley A. Plotkin. History of Vaccine Development. Springer 2011.
Vaccine Fact Book 2013. http://www.phrma.org/sites/default/files/pdf/PhRMA_Vaccine_FactBook_2013.pdf
WHO, UNICEF, World Bank. State of the world’s vaccines and immunization, 3rd ed., Geneva, World Health Organization, 2009.
Lectures
1 History of vaccines and anti-vaccination movements
Dr. Szendi Katalin
2 Epidemiology of infectious diseases, morbidity and mortality rates before and after vaccine introduction. Is there any benefit of
vaccination?
Dr. Szendi Katalin
3 Epidemiological studies on vaccination, are there any at all?
Dr. Szendi Katalin
4 Morbidity, mortality, incidence, prevalence. Statistics, data availability, official sources. Are there enough and reliable data to
prove the effectiveness or safety of vaccines?
Dr. Szendi Katalin
5 Groups of vaccinations. Why are they compulsory?
Dr. Szendi Katalin
6 Types of vaccinations. Are there any unnecessary ones (e.g. BCG)? Is it possible that the only purpose of the pharmaceutical
industry is to increase their profits?
Dr. Szendi Katalin
7 The function of vaccination, types of immunity. Is artificial induction of immunity good for our immune system? Does it result
in more benefits if the diseases are fought off in a natural way?
Dr. Szendi Katalin
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8 The efficiency of vaccines. Do the European countries with better health indicators also have better epidemiological situation
than Hungary? Questions of herd immunity.
Dr. Szendi Katalin
9 Vaccine effectiveness. Are there any positive health effects, or just does the government want to make us believe in counterfeit
statistical data?
Dr. Szendi Katalin
10 Vaccination safety, components. Are the ingredients in vaccines dangerous? Do they cause any harm to health? Diversity of
conspiracy theories.
Dr. Szendi Katalin
11 Risks of vaccines, vaccination health hazards. Do the vaccines do more harm than good? MMR and autism. Mercury and autism.
Aluminium and autism.
Dr. Szendi Katalin
12 Legal background. The legal regulation of vaccines. The pros and cons of compulsory vaccination. What is the point of it? The
reason for the existence of free choice.
Dr. Szendi Katalin
Practices
1 Anti-vaccination activities in Hungary and abroad.
2 Do we have to deal with the anti-vaccination movements? Anti-vaccination movements, hazards, duties. Psychology of the anti-
vaccination attitudes.
Seminars
Exam topics/questions
Neptun
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Szendi Katalin (SZKFAPO.PTE)
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OPE-BEE-T BASICS OF EPIDEMIOLOGY
Course director: DR. TÍMEA VARJAS, assistant professor
Department of Public Health Medicine
1 credit ▪ midsemester grade ▪ Elective subject for the Medical/Biological module ▪ autumn semester ▪ recommended semester: 3
Number of hours/semester: 8 lectures + 4 practices + 2 seminars = total of 14 hours
Course headcount limitations (min.-max.): 1 – 30 Prerequisites: OPA-B2E completed
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
During the semester students are acquainted with the basics of epidemiology and epidemiological studies frequently used in scientific
literature. With this knowledge one can easily elucidate and interpret scientific publications.
The course is recommended for pharmacists and dentists.
Conditions for acceptance of the semester
Absences should not exceed 15% of lectures and practicals (2x45 min). Otherwise signature of grade book is denied.
Mid-term exams
Examination: written test
Making up for missed classes
Based on individual consideration
Reading material
- Obligatory literature
- Literature developed by the Department
PPT-presentations (Neptun)
- Notes
- Recommended literature
Lectures
1 Definition, history, goal and concept of epidemiology
Dr. Szabó István
2 Definition, history, goal and concept of epidemiology
Dr. Szabó István
3 Epidemiological indicators and their application (incidence, prevalence)
Dr. Szabó István
4 Epidemiological indicators and their application (RR, OR, statistical significance)
Dr. Szabó István
5 Epidemiological studies
Dr. Szabó István
6 Epidemiological studies
Dr. Szabó István
7 Epidemiology and Evidence Based Medicine
Dr. Szabó István
8 Epidemiology and Evidence Based Medicine
Dr. Szabó István
Practices
1 Basic epidemiological calculations
2 Basic epidemiological calculations
3 Analyzis of selected scientific publications
4 Analyzis of selected scientific publications
Seminars
1 Standardization, Screening
2 Bias, error
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73
Exam topics/questions
Neptun
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Szabó István (SZIGABO.PTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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OPE-EHS-T HUNGER, SATIETY AND DISTURBANCES OF BODY WEIGHT REGULATION
Course director: DR. LÁSZLÓ LÉNÁRD I, emeritus professor
Institute of Physiology
1 credit ▪ midsemester grade ▪ Elective subject for the Medical/Biological module ▪ autumn semester ▪ recommended semester: 3
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPA-FI2 completed + OPO-MB2 completed
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
Based on recent results, feeding related physiological and pathophysiological mechanisms will be discussed. Students will be trained to
understand these mechanisms. The knowledge based on this course will highly contribute to better understanding further clinical studies
on human diseases.
Peripheral and central mechanisms of hunger, satiety, salt appetite and body weight regulation will be discussed. Lectures will include
the following topics: Neural and humoral processes. Peripheral and central glucose-monitoring system. The role of neuropeptides in the
control of feeding and hydromineral balance. Pathological processes: obesity, bulimia, anorexia.
Conditions for acceptance of the semester
Absence from no more than 25% of the lectures.
Mid-term exams
Written exams.
Making up for missed classes
-
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
Notes taken at the lectures.
- Recommended literature
Lectures
1 Basic parameters: caloric intake, energy expenditure, measurement of food and water intake, body weight and body mass index.
Body weight curves during development, adulthood and senescence.
Dr. Lénárd László I
2 Peripheral and central mechanisms of body weight regulation.
Dr. Lénárd László I
3 Endocrine mechanisms: the role of different hormones.
Dr. Lénárd László I
4 Body weight loss, obesity. Long run pathological consequences of obesity.
Dr. Lénárd László I
5 Hunger and satiety. Motivational mechanisms. Overeating, rejection.
Dr. Lénárd László I
6 Hypothalamic dual centers. The role of limbic system in hunger and satiety.
Dr. Lénárd László I
7 Peripheral glucose related signals. The central glucose monitoring system.
Dr. Lénárd László I
8 Food rewarded learning, the role of reinforcement. Aversive learning, the role of conditioned taste aversion in feeding habits.
Dr. Lénárd László I
9 The sight, odor, taste and texture of foods and their detection in the limbic system. Ingestive and rejective mimetic responses and
their genetic determination.
Dr. Lénárd László I
10 The role of monoamines in the regulation of feeding. Similarities of food rewarded learning and addictive behavior. The role of
dopamine and neuropeptides.
Dr. Lénárd László I
11 Orexigenic and anorexigenic neuropeptides.
Dr. Lénárd László I
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12 The role of the central angiotensinergic system in drinking and hydromineral balance.
Dr. Lénárd László I
13 Childhood obesity and cognitive processes.
Dr. Lénárd László I
14 Anorexia nervosa, bulimia and binge eating. Clinical relevance of animal experiments
Dr. Lénárd László I
Practices
Seminars
Exam topics/questions
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPE-HOS-T HORMONAL REGULATORY MECHANISMS IN HEALTH AND DISEASE
Course director: DR. MARIETTA VÉRTES M, professor emeritus
Institute of Physiology
2 credit ▪ midsemester grade ▪ Elective subject for the Medical/Biological module ▪ autumn semester ▪ recommended semester: 3
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPO-MB2 completed
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The aim of the program is to clarify the role of hormones and hormonal networks in the maintenance of homeostasis and regulation of
body processes including reproduction. The lectures attempts to provide an overview of function of hormonal networks and the integrity
of nervous and endocrine regulation in human body.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Written exam, multiple choice questions from lectures
Making up for missed classes
Oral discussion of given chapter
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
Greenstein B.: Endocrinology at a Glance, Springer 1999
Williams Textbook of Endocrinology, 2004
Goodman M: Basic Medical Endocrinology, 2000
Greenspan FS, Baxter JD: Basic and Clinical Endocrinology, 2003
Lectures
1 Types of hormones. Hormone synthesis, transport
Dr. Vértes M Marietta
2 Mechanism of hormone action, hormone receptors
Dr. Vértes M Marietta
3 Signal transduction. Regulation of tissue responsiveness to hormones
Dr. Vértes M Marietta
4 Endocrine and nervous system relationships
Dr. Vértes M Marietta
5 Hypothalamo-hypophyseal tract
Dr. Vértes M Marietta
6 Anterior pituitary. Feedback regulation
Dr. Vértes M Marietta
7 Principles of hormonal integration.
Dr. Vértes M Marietta
8 Hormonal regulation of fuel metabolism. General concepts
Dr. Vértes M Marietta
9 Growth hormone and IGF
Dr. Vértes M Marietta
10 Hormones of pancreas
Dr. Vértes M Marietta
11 Metabolism in diabetes mellitus
Dr. Vértes M Marietta
12 Regulatory peptides in the gut
Dr. Vértes M Marietta
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13 Cortisol
Dr. Vértes M Marietta
14 Stress and thyroid hormones
Dr. Vértes M Marietta
15 Regulation of salt and water balance. General concepts
Dr. Vértes M Marietta
16 Hypothalamo-neurophyseal system
Dr. Vértes M Marietta
17 Renin-angiotenzin-aldosteron system
Dr. Vértes M Marietta
18 Natriuretic hormones
Dr. Vértes M Marietta
19 Hormones in pregnancy and during fetal development
Dr. Kovács Kálmán András
20 Hormones in pregnancy and during fetal development
Dr. Kovács Kálmán András
21 Menstrual cycle. Contraception
Dr. Kovács Kálmán András
21 Menstrual cycle. Contraception
Dr. Kovács Kálmán András
23 Breast development. Hormones during lactation
Dr. Vértes M Marietta
24 Ontogeny of endocrine system
Dr. Vértes M Marietta
25 Hormones and bones
Dr. Vértes M Marietta
26 Endocrine system and aging
Dr. Vértes M Marietta
27 Discussion
Dr. Vértes M Marietta
28 Exams
Dr. Vértes M Marietta
Practices
Seminars
Exam topics/questions
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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78
OPE-TSA-T STATISTICAL ANALYSIS OF THESIS AND STUDENT RESEARCH PROJECTS
Course director: DR. KORNÉLIA FARKAS-BORBÁS, assistant professor
Institute of Bioanalysis
1 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ both semesters ▪ recommended semester: 3
Number of hours/semester: 7 lectures + 7 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 3 – 20 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
This course is for those students who are working on a student research plan or working on their thesis. They can process their own data
and learn the theory of the applied statistical methods as well.
Conditions for acceptance of the semester
Problem solving, oral report
Mid-term exams
Making up for missed classes
Consultation
Reading material
- Obligatory literature
- Literature developed by the Department
Own database
- Notes
- Recommended literature
Andrew F. Siegel: Statistics and Data Analysis. An introduction, John Wiley & Sons, 1988
Douglas G. Altman: Practical Statistics for Medical Research, Chapman & Hall, 1994
P. Armitage and G. Berry: Statistical Methods in Medical Research, Blackwell Science, 1994
Robert R. Sokal / F. James Rohlf: Biometry, W. H. Freeman and Company, New York, 1981
Lectures
1 Set the data and complete the database for statistical processing
Borbásné Dr. Farkas Kornélia
2 Select the right statistical methods
Borbásné Dr. Farkas Kornélia
3 Learn the theory of the selected methods
Borbásné Dr. Farkas Kornélia
4 Learn the theory of the selected methods
Borbásné Dr. Farkas Kornélia
5 Interpret the results
Borbásné Dr. Farkas Kornélia
6 Interpret the results
Borbásné Dr. Farkas Kornélia
7 Conclusions
Borbásné Dr. Farkas Kornélia
Practices
1 Set the data and complete the database for statistical processing
2 Select the right statistical methods
3 Learn the theory of the selected methods
4 Learn the theory of the selected methods
5 Interpret the results
6 Interpret the results
7 Conclusions
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Seminars
Exam topics/questions
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Borbásné Dr. Farkas Kornélia (FAKAAA.T.JPTE)
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OPE-TSS-T MEDICAL APPLICATIONS OF MASS SPECTROMETRY
Course director: DR. LÁSZLÓ MÁRK, associate professor
Department of Biochemistry and Medical Chemistry
2 credit ▪ midsemester grade ▪ Elective subject for the Pharmaceutical module ▪ autumn semester ▪ recommended semester: 3
Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 3 – 50 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
In medical sciences, emphasis is increasingly placed on instrumental techniques and accurate, quantitative measurements. This course is
give an overall review about the modern mass spectrometry and it shows the medical applications of the MS in the clinical and diagnostic
practice.
Topics:
Introduction to MS. Ionsources, analizators, detectors. Separation techniques. Sample handling. Biomedical sampling. Bioinformatics.
Proteomics, metabolomics and lipidomics. Biomarker discovery. Mass spectrometric imaging techniques.
Conditions for acceptance of the semester
Written exam. Max. absences: 20%.
Mid-term exams
Making up for missed classes
Not possible.
Reading material
- Obligatory literature
- Literature developed by the Department
Lecture slides and notes.
- Notes
- Recommended literature
Vékey et al: Medical Applications of Mass Spectrometry, 2008.
Hoffman et al: Mass Spectrometry, 2007
Lectures
1 Introduction
Dr. Márk László
2 Basics of mass spectrometry
Dr. Márk László
3 Basics of mass spectrometry
Dr. Márk László
4 Ionization techniques
Dr. Márk László
5 Analizators
Dr. Márk László
6 Detectors, The mass spectrum
Dr. Márk László
7 Biomedical sampling
Dr. Márk László
8 Separation techniques, sample preparation
Dr. Márk László
9 Separation techniques, sample preparation
Dr. Márk László
10 Proteomics
Dr. Márk László
11 Proteomics
Dr. Márk László
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12 Metabolomics
Dr. Márk László
13 Metabolomics
Dr. Márk László
14 Mass spectrometry of endocrine system
Dr. Márk László
15 Mass spectrometry of endocrine system
Dr. Márk László
16 Biomarker discovery
Dr. Márk László
17 Biomarker discovery
Dr. Márk László
18 Lipidomics
Dr. Márk László
19 Lipidomics
Dr. Márk László
20 Proteomics of viruses and bacteria
Dr. Márk László
21 Proteomics of viruses and bacteria
Dr. Márk László
22 Molecular imaging by MS
Dr. Márk László
23 Exam
Dr. Márk László
24 Exam
Dr. Márk László
Practices
Seminars
Exam topics/questions
Ionsources.
Analizators.
Detectors.
Separation techniques.
Sample handling. Biomedical sampling.
Bioinformatics.
Proteomics.
Metabolomics
Lipidomics.
Biomarker discovery.
Mass spectrometric imaging techniques.
MS of endocrine system.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPE-WMI-T WEAK MOLECULAR INTERACTIONS
Course director: DR. SÁNDOR KUNSÁGI MÁTÉ, associate professor
Department of Pharmaceutical Chemistry
2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ both semesters ▪ recommended semester: 3
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 2 – 12 Prerequisites: általános és szervetlen k completed
Topic
Types of molecular interactions. Chemical equilibrium based on the weak molecular interactions. Determination of the chemical
equilibrium and the stoichiometry of the complexes. Correlation between the chemical equilibrium and the free enthalpy. Investigation
of the weak interaction by spectroscopical methods. Application of the Job’s method in the fluorescence measurements. Direct measuring
the interaction enthalpy by differential scanning calorimetry. Interactions of aromatic compounds. Interactions of antibiotics with
membrane elements. Interactions of bioactive molecules with DNA. Investigations of model-systems: interactions of calixarenes with
phenols and fullerenes. Packing of drug molecules by molecular containers. Interactions of bioactive molecules with elements of cell
membranes. Self-assembly of some hormones by weak interactions.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
One written exam during the semester, the acceptance level is 60%.
Making up for missed classes
There is no possibility to make up for a missed lecture and practice
Reading material
- Obligatory literature
David Freifelder: Physical Biochemistry
- Literature developed by the Department
Shyllabus and ppt presentation is available.
- Notes
- Recommended literature
Atkins: Physical Chemistry I-III.
David Freifelder: Physical Biochemistry
Lectures
1 Types of molecular interactions.
Dr. Kunsági Máté Sándor
2 Types of molecular interactions.
Dr. Kunsági Máté Sándor
3 Chemical equilibrium based on the weak molecular interactions.
Dr. Kunsági Máté Sándor
4 Chemical equilibrium based on the weak molecular interactions.
Dr. Kunsági Máté Sándor
5 Determination of the chemical equilibrium and the stoichiometry of the complexes.
Dr. Kunsági Máté Sándor
6 Determination of the chemical equilibrium and the stoichiometry of the complexes.
Dr. Kunsági Máté Sándor
7 Correlation between the chemical equilibrium and the free enthalpy.
Dr. Kunsági Máté Sándor
8 Correlation between the chemical equilibrium and the free enthalpy.
Dr. Kunsági Máté Sándor
9 Investigation of the weak interaction by measuring the fluorescence.
Dr. Kunsági Máté Sándor
10 Investigation of the weak interaction by measuring the fluorescence.
Dr. Kunsági Máté Sándor
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11 Application of the Job’s method in the fluorescence measurements.
Dr. Kunsági Máté Sándor
12 Application of the Job’s method in the fluorescence measurements.
Dr. Kunsági Máté Sándor
13 Direct measuring the interaction enthalpy by differential scanning calorimetry.
Dr. Kunsági Máté Sándor
14 Direct measuring the interaction enthalpy by differential scanning calorimetry.
Dr. Kunsági Máté Sándor
15 Interactions of aromatic compounds. Interactions of bioactive compounds with DNA.
Dr. Kunsági Máté Sándor
16 Interactions of aromatic compounds. Interactions of bioactive compounds with DNA.
Dr. Kunsági Máté Sándor
17 Investigations of model-systems: interactions of calixarenes with phenols and fullerenes.
Dr. Kunsági Máté Sándor
18 Investigations of model-systems: interactions of calixarenes with phenols and fullerenes.
Dr. Kunsági Máté Sándor
19 Investigations of the conformation changes of proteins by fluorescence and calorimetric methods.
Dr. Kunsági Máté Sándor
20 Investigations of the conformation changes of proteins by fluorescence and calorimetric methods.
Dr. Kunsági Máté Sándor
21 Investigations of the conformation changes of proteins by fluorescence and calorimetric methods.
Dr. Kunsági Máté Sándor
22 Controlling of self-assembly of some hormones by weak interactions.
Dr. Kunsági Máté Sándor
23 Controlling of self-assembly of some hormones by weak interactions.
Dr. Kunsági Máté Sándor
24 Controlling of self-assembly of some hormones by weak interactions.
Dr. Kunsági Máté Sándor
25 Modifications of structure of serum albumins by molecular capsules. Interactions of molecular capsules with aromatic amino
acids at terminated positions.
Dr. Kunsági Máté Sándor
26 Effect of Molecular Environment on the Formation Kinetics of Complexes of Malvidin-3-O-glucoside with Caffeic Acid and
Catechin
Dr. Kunsági Máté Sándor
27 Competitive hydrogen bonds associated with the effect of primycin antibiotic on oleic acid as a building block of plasma
membranes.Complex formation between primycin and ergosterol: entropy - driven initiation of modification of the fungal plasma
membrane structure
Dr. Kunsági Máté Sándor
28 Role of the Conformational Freedom of the Skeleton in the Complex Formation Ability of Resorcinarene Derivatives toward a
Neutral Phenol Guest
Dr. Kunsági Máté Sándor
Practices
Seminars
Exam topics/questions
Types of molecular interactions.
Chemical equilibrium based on the weak molecular interactions.
Determination of the chemical equilibrium and the stoichiometry of the complexes.
Correlation between the chemical equilibrium and the Gibbs free energy.
Investigation of the weak interaction by spectroscopical methods.
Application of the Job’s method in the fluorescence measurements.
Direct measuring the interaction enthalpy by differential scanning calorimetry.
Interactions of aromatic compounds.
Interactions of bioactive compounds with DNA.
Investigations of model-systems: interactions of calixarenes with phenols and fullerenes.
Packing of drug molecules by molecular containers.
Interactions of bioactive molecules with elements of cell membranes.
Self-assembly of some hormones by weak interactions.
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Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Kunsági Máté Sándor (KUSFAAP.PTE)
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OPF-DRD-T DRUG DESIGN
Course director: DR. CSABA HETÉNYI, associate professor
Department of Pharmacology and Pharmacotherapy
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 1 – 300 Prerequisites: none
Topic
The course offers an overview of the whole process of drug design between selection of the disease and marketing of the drug. The
introductory lectures are followed by detailed reviews of certain phases of drug design including prediction of both drug action and
pharmacokinetic properties. In this regard, theoretical and experimental methods of drug design will be also introduced. Case studies will
demonstrate successful examples and also difficulties arising during the design process. Students with a researcher attitude are primary
targets of this course. Besides them, the course provides useful knowledge for future medical doctors and pharmacists as it explains the
complex process of drug discovery in a comprehensible way. This hopefully helps the students navigating in the jungle of laws of
pharmacology also used in molecular design. Furthermore, the course deals with the problems of prediction of toxicity and side-effects,
and discusses certain questions of production and legalization process of new drugs, as well. In Journal Club sessions, recent research
articles will be featured with the students to deepen their knowledge in the areas discussed during the previous lectures. In this way, the
students can discover further connections themselves and make sure of the usefulness of their newly obtained knowledge in drug design.
Conditions for acceptance of the semester
Jelenleg a választható és elektív kurzusok esetén a szabályzat nem tartalmaz részvételi követelményt. Amennyiben szükséges itt valamit
megjelölnöm, akkor 25 %, de csak azért teszem, hogy kitölthető legyen az űrlap. Javasoltam a Tanulmányi Bizottság vezetőjének a
helyzet szabályzását és 50 % mértéket a hiányzásoknál.
Mid-term exams
There is a final test announced at the end of the semester. The test will include multiple choice questions and short essays. A mark is
offered according to the results of the written test and optionally by evaluation of the student’s presentation prepared for the Journal
Club. The student can improve the mark according to university regulations.
Making up for missed classes
Replacement is possible according to personal consultation.
Reading material
- Obligatory literature
- Literature developed by the Department
The material of the course including pdfs of lectures and lists of questions will be made downloadable from the web site of the
Department of Pharmacology and Pharmacotherapy or a link will be provided during the lectures / in an e-mail.
- Notes
- Recommended literature
Patrick GL: An Introduction to Medicinal Chemistry, Oxford University Press
Lectures
1 Selection of the disease. Goals, terminology, trends.
Dr. Hetényi Csaba
2 Conditions. Strategies. Ligand-based design.
Dr. Hetényi Csaba
3 Traditional design.
Dr. Hetényi Csaba
4 Target-based drug design.
Dr. Hetényi Csaba
5 Target selection and validation.
Dr. Hetényi Csaba
6 Protein targets 1. General overview, structural proteins.
Dr. Hetényi Csaba
7 Protein targets 2. Enzymes and receptors.
Dr. Hetényi Csaba
8 Experimental structure determination methods.
Dr. Hetényi Csaba
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9 Theoretical structure determination methods.
Dr. Hetényi Csaba
10 Lipids and nucleic acids as targets.
Dr. Hetényi Csaba
11 Journal club 1. Comparison of strategies
Dr. Hetényi Csaba
12 Journal club 2. Evaluation of targets
Dr. Hetényi Csaba
13 Journal club 3. X-ray crystallography and NMR
Dr. Hetényi Csaba
14 Journal club 4. Cryo-electronmicroscopy
Dr. Hetényi Csaba
15 Experimental methods of lead selection and design.
Dr. Hetényi Csaba
16 Molecular complexes of leads. Thermodynamic and kinetic stability.
Dr. Hetényi Csaba
17 Theoretical methods of lead selection and design.
Dr. Hetényi Csaba
18 Lead optimizations, transformations.
Dr. Hetényi Csaba
19 ADMETox optimization 1. Goals, general description.
Dr. Hetényi Csaba
20 ADMETox optimization 2. Methods.
Dr. Hetényi Csaba
21 Termination of design. Production and development.
Dr. Hetényi Csaba
22 Side-effects and postmarketing surveillance.
Dr. Hetényi Csaba
23 Case study 1. The design of antiviral drugs.
Dr. Hetényi Csaba
24 Case study 2. The design of anti-cancer drugs.
Dr. Hetényi Csaba
25 Journal club 5. Development of new methods
Dr. Hetényi Csaba
26 Journal club 6. Paradigm shifts of drug design
Dr. Hetényi Csaba
27 Journal club 7. Molecular dynamics
Dr. Hetényi Csaba
28 Journal club 8. Docking
Dr. Hetényi Csaba
Practices
Seminars
Exam topics/questions
Lists of questions will be provided at the end of each lecture specifying the required knowledge.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPF-EBK-T FOOD SAFETY AND CRISIS SITUATIONS
Course director: DR. TÍMEA VARJAS, assistant professor
Department of Public Health Medicine
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 4 – 30 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
Although food legislation and legal background is strict in EU some food safety crises and emergencies occur we can hear just a few
word in the media about. This course „pulls the veil” of the background, causes and concealed information of food safety crises.
Topics are about the most interesting and important information of these situations.
Conditions for acceptance of the semester
Absences should not exceed 15% of lectures and practicals (2x45 min). Otherwise signature of grade book is denied.
Mid-term exams
Examination: written test
Making up for missed classes
based on individual consideration
Reading material
- Obligatory literature
- Literature developed by the Department
PPT-presentations (Neptun)
- Notes
- Recommended literature
Lectures
1 Introduction, European and Hungarian food safety regulation I
Dr. Raposa László Bence
2 Introduction, European and Hungarian food safety regulation II
Dr. Raposa László Bence
3 Cases and concealed facts I. (Historical overview)
Dr. Raposa László Bence
4 Cases and concealed facts II. (Historical overview)
Dr. Raposa László Bence
5 Crisis management and communication I
Dr. Raposa László Bence
6 Crisis management and communication II
Dr. Raposa László Bence
7 Cases and concealed facts III
Dr. Raposa László Bence
8 Cases and concealed facts IV
Dr. Raposa László Bence
9 Food industry „tricks”: Changes which the layman does not realize I
Dr. Raposa László Bence
10 Food industry „tricks”: Changes which the layman does not realize II
Dr. Raposa László Bence
11 Actual food safety crisis I
Dr. Raposa László Bence
12 Actual food safety crisis II
Dr. Raposa László Bence
13 Summary
Dr. Raposa László Bence
14 Exam
Dr. Raposa László Bence
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Practices
Seminars
Exam topics/questions
Neptun
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPF-GMS-T GENETICALLY MODIFIED ORGANISMS AND OUR HEALTH
Course director: DR. ZOLTÁN GYÖNGYI, senior research fellow
Department of Public Health Medicine
1 credit ▪ midsemester grade ▪ Optional subject ▪ both semesters ▪ recommended semester: 3
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 30 Prerequisites: OPO-MB2 completed
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The application of genetically modified organisms (GMOs) gains more and more ground in food industry. Over the direct health effect,
they have an impact on human economy and health modifying natural environment. The topic provokes social debate, in which, in lack
of information, delusions also appear.
The goal of the education is that students receive impartial knowledge of the role of GMOs in our life and their beneficial or possible
harmful impact on our health.
During the education students receive a knowledge of molecular background of production of GMOs, their role in agriculture, the
appeared cases and possible health risks, their occurrence in foodstuffs, medical applications, tests, regulations, authorization, economical
and social impacts.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
There is a final test only on the last lecture/practice. In case of absence there can be a personal consultation.
Making up for missed classes
Consultation with good cause.
Reading material
- Obligatory literature
- Literature developed by the Department
Lecture slides on Coospace
- Notes
- Recommended literature
Morgan, Sally: Superfoods: Genetic Modification of Foods (Science at the Edge), Heinemann, 2003 ISBN 1-4034-4123-5.
Lectures
1 The appearance of genetically modified organisms (GMOs)
Dr. Gyöngyi Zoltán
2 Role of GMOs in agriculture
Dr. Gyöngyi Zoltán
3 Basics of genetically modification I
Dr. Gyöngyi Zoltán
4 Basics of genetically modification II
Dr. Gyöngyi Zoltán
5 Possible harmful effect of GMOs to health
Dr. Gyöngyi Zoltán
6 Background of deaths caused by GM food
Dr. Gyöngyi Zoltán
7 Prevention of GMO induced health hazard
Dr. Gyöngyi Zoltán
8 Genetically modification in medicine
Dr. Gyöngyi Zoltán
9 GMOs in food I.
Dr. Gyöngyi Zoltán
10 GMOs in food II.
Dr. Gyöngyi Zoltán
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11 Authorization of GMOs
Dr. Gyöngyi Zoltán
12 Regulation of application
Dr. Gyöngyi Zoltán
13 Impact of GMOs on nature environment and eco farms
Dr. Gyöngyi Zoltán
14 Effect of GM business on economy, social debates and the flow of information
Dr. Gyöngyi Zoltán
Practices
Seminars
Exam topics/questions
1. Reasons, why GMOs are created
2. The role of GMOs in the agriculture
3. Impact of GMOs on natural environment and organic farms
4. Molecular basics of genetically modifications
5. Application of genetic modification in the medicine
6. The cause of deaths because of GM food
7. Possible harmful effect of GMOs to health
8. Prevention of harmful effect of GMOs
9. Occurrence of GMOs in foodstuffs, food tests
10. Authorization of GMOs, social debate, flow of information
11. Health impacts of glyphosate
12. Health impacts of Bt toxin
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
91
OPF-H3A-T MEDICAL HUNGARIAN 3A - BASICS OF MEDICAL COMMUNICATION FOR STUDENTS OF
PHARMACY
Course director: DR. GÁBOR RÉBÉK-NAGY, associate professor
Department of Languages for Specific Purposes
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3
Number of hours/semester: 0 lectures + 28 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPE-H2A completed + OPF-H3B parallel
Topic
This course in devoted to the acquisition of language and communicative functions of the basic history taking process and the description
of medications.
Conditions for acceptance of the semester
Participation in class work is obligatory. In case absences exceed 25% of total class time, the course will be regarded as uncompleted. In
the case of absences up to 25% of total class time, oral examination will have to be taken
Mid-term exams
-
Making up for missed classes
Reading material
- Obligatory literature
- Literature developed by the Department
Mária Győrffy: English for Doctors, Idióma Bt. Pécs, 2001 - can be purchased in the Department
- Notes
- Recommended literature
Lectures
Practices
1 Family History, social history and previous diseases
2 Family History, social history and previous diseases
3 Complaint and Pain
4 Complaint and Pain
5 Headache, dizziness
6 Perspiration, nausea, vomiting
7 Vision, shortness of breath, cough-Listening comprehension and speaking skills-Listening comprehension and speaking skills
8 Stool, urine
9 Stool, urine
10 Heart complaints, appetite
11 Shivering, fever, oedema
12 Frequent diseases
13 Oesophagus, stomach, gallbladder
14 Bowel diseases, cardiovascular diseases
15 Forms of medications
16 Test 1
17 Types of medications
18 Types of medications
19 Instructions concerning the application of medications: oral medications
20 Instructions concerning the application of medications: oral medications
21 Instructions concerning the application of medications: drops
22 Instructions concerning the application of medications: creams and ointments
23 Instructions concerning the application of medications: creams and ointments
24 Prescriptions
25 Consolidation
26 Consolidation
27 Test 2
28 Consolidation
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Seminars
Exam topics/questions
-
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Hegedűs Anita (HEAAAA.B.JPTE), Dr. Rébék-Nagy Gábor (REGCAC.B.JPTE), Dr. Warta Vilmos (WAVEAB.B.JPTE), Eklicsné
Dr. Lepenye Katalin (EKLAXA.B.JPTE), Hild Gabriella (MAGAAD.B.JPTE), Lokodiné Szolcsányi Judit (LOSIAAB.PTE),
Mészégetőné Halmos Éva (MEHHABE.PTE), Móriczné Győrffy Mária (MOGPAAP.PTE), Ronczykné Berta Anikó
(BEAAAI.B.JPTE), Szántóné Dr. Csongor Alexandra (CSAAAA.B.JPTE), Váradi Katalin (VAKHAAE.PTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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OPF-H3B-T MEDICAL HUNGARIAN 3B - MEDICAL COMMUNICATION IN PRACTICE FOR STUDENTS OF
PHARMACY
Course director: DR. GÁBOR RÉBÉK-NAGY, associate professor
Department of Languages for Specific Purposes
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3
Number of hours/semester: 0 lectures + 28 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPE-H3A parallel + OPE-H2B completed
Topic
This course serves the skills development based on language and communicative functions acquired in course 3A.
Conditions for acceptance of the semester
Participation in class work is obligatory. In case absences exceed 25% of total class time, the course will be regarded as uncompleted. In
the case of absences up to 25% of total class time, oral examination will have to be taken
Mid-term exams
-
Making up for missed classes
Reading material
- Obligatory literature
- Literature developed by the Department
Mária Győrffy: English for Doctors, Idióma Bt. Pécs, 2001 - can be purchased in the Department
- Notes
- Recommended literature
Lectures
Practices
1 Family History, social history and previous diseases - Listening comprehension and speaking skills
2 Family History, social history and previous diseases - Listening comprehension and speaking skills
3 Complaint and Pain - Listening comprehension and speaking skills
4 Complaint and Pain - Listening comprehension and speaking skills
5 Headache, dizziness - Listening comprehension and speaking skills
6 Perspiration, nausea, vomiting - Listening comprehension and speaking skills
7 Vision, shortness of breath, cough - Listening comprehension and speaking skills
8 Stool, urine - Listening comprehension and speaking skills
9 Stool, urine - Listening comprehension and speaking skills
10 Heart complaints, appetite - Listening comprehension and speaking skills
11 Shivering, fever, oedema - Listening comprehension and speaking skills
12 Frequent diseases - Listening comprehension and speaking skills
13 Oesophagus, stomach, gallbladder - Listening comprehension and speaking skills
14 Bowel diseases, cardiovascular diseases - Listening comprehension and speaking skills
15 Forms of medications - Listening comprehension and speaking skills
16 Test 1
17 Types of medications - Listening comprehension and speaking skills
18 Types of medications - Listening comprehension and speaking skills
19 Instructions concerning the application of medications: oral medications - Listening comprehension and speaking skills
20 Instructions concerning the application of medications: oral medications - Listening comprehension and speaking skills
21 Instructions concerning the application of medications: drops - Listening comprehension and speaking skills
22 Instructions concerning the application of medications: creams and ointments - Listening comprehension and speaking skills
23 Instructions concerning the application of medications: creams and ointments - Listening comprehension and speaking skills
24 Prescriptions - Listening comprehension and speaking skills
25 Consolidation
26 Consolidation
27 Test 2
28 Consolidation
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Seminars
Exam topics/questions
-
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Hegedűs Anita (HEAAAA.B.JPTE), Dr. Rébék-Nagy Gábor (REGCAC.B.JPTE), Dr. Warta Vilmos (WAVEAB.B.JPTE), Eklicsné
Dr. Lepenye Katalin (EKLAXA.B.JPTE), Hamarné Sávay Judit (HASMAAO.PTE), Hild Gabriella (MAGAAD.B.JPTE), Horváth Lilla
Anita (HOLFABP..PTE), Kurdiné Molnár Eszter (KUMPAAK.PTE), Lokodiné Szolcsányi Judit (LOSIAAB.PTE), Mészégetőné
Halmos Éva (MEHHABE.PTE), Móriczné Győrffy Mária (MOGPAAP.PTE), Nagy Gabriella (NAGMAAO.PTE), Ronczykné Berta
Anikó (BEAAAI.B.JPTE), Szántóné Dr. Csongor Alexandra (CSAAAA.B.JPTE), Váradi Katalin (VAKHAAE.PTE)
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OPF-IPM-T INNOVATION AND PROJECT MANAGEMENT FROM A BUSINESS PERSPECTIVE (KÜLÖN
KURZUS!!!)
Course director: DR. RITA BOGNÁR, administrative officer
Department of Biochemistry and Medical Chemistry
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 1 – 30 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The main objective of the innovation and project management course is to develop the business orientation skills of the students, while
deepening their knowledge in project management theory, methods and practice. Participants will have the capability how to develop
innovative projects for business.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Written test will be on the week 13.
Making up for missed classes
After consultation.
Reading material
- Obligatory literature
Not relevant.
- Literature developed by the Department
Lectures in pdf form will be available on Neptun Meet Street.
- Notes
Not relevant.
- Recommended literature
1. Joseph W. Weiss, Robert K. Wysocki (1992): 5-Phase Project Management: A Practical Planning & Implementation Guide,
Addison-Wesley
2. John Hauser, Gerard J. Tellis and Abbie Griffin: A Review and Agenda for „Marketing Science”, Marketing Science, Vol. 25, No.
6, 25th Anniversary Issue (Nov. - Dec., 2006), pp. 687-717
3. Barbara J. Gabrys, Jane A. Langdale (2012): How to succeed as a scientist, From Postdoc to Professor, Cambridge University
Press, New York, pp.45-57.
Lectures
1 Basic of project management (definition, objectives)
Dr. Bognár Rita
2 Global business overview
Dr. Bognár Rita
3 Project life cycle
Dr. Bognár Rita
4 Different type of business organisations
Dr. Bognár Rita
5 Project initialisation (structure, work packages)
Dr. Bognár Rita
6 Leadership of a project
Dr. Bognár Rita
7 Human resource management (team building, teamwork)
Dr. Bognár Rita
8 Project planning 1. (time, resources)
Dr. Bognár Rita
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9 Project planning 2. (cost, risk, communication)
Dr. Bognár Rita
10 Project network
Dr. Bognár Rita
11 Project communication tools
Dr. Bognár Rita
12 Project protocol
Dr. Bognár Rita
13 Financial management 1.
Dr. Bognár Rita
14 Financial management 2.
Dr. Bognár Rita
15 Procurement management
Dr. Bognár Rita
16 Contracts
Dr. Bognár Rita
17 Risk management
Dr. Bognár Rita
18 Conflict management
Dr. Bognár Rita
19 Innovation management 1.(Intellectual properties)
Dr. Bognár Rita
20 Innovation management 2. (Patent)
Dr. Bognár Rita
21 Project controlling
Dr. Bognár Rita
22 Project monitoring
Dr. Bognár Rita
23 Project reporting 1.
Dr. Bognár Rita
24 Project reporting 2.
Dr. Bognár Rita
25 Written test
Dr. Bognár Rita
26 Written test
Dr. Bognár Rita
27 Project closing
Dr. Bognár Rita
28 Project maintenance
Dr. Bognár Rita
Practices
Seminars
Exam topics/questions
Neptun Meet Street
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Bognár Rita (BOREAA.K.JPTE)
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OPF-MGE-T MOLECULAR GERONTOLOGY
Course director: DR. KRISZTIÁN KVELL, associate professor
Department of Pharmaceutical Biotechnology
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 200 Prerequisites: OPE-MS1 completed
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The curriculum covers physiological aspects of ageing and the molecular background of the ageing process, at cell, intracellular signaling
and nucleic acid level. It highlights the potential molecular intervention possibilities to slow down the ageing process and decrease
development of age related diseases.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Writing test
Making up for missed classes
None
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
www.medbiotech.com
- Recommended literature
Lectures
1 Basic Knowledge in Gerontology
Dr. Kvell Krisztián
2 Aging Theories
Dr. Kvell Krisztián
3 Mitochondrial Aging
Dr. Kvell Krisztián
4 Aging and Gene Expression
Dr. Kvell Krisztián
5 Genetic Background of Longevity
Dr. Kvell Krisztián
6 Alterations of the Genome due to Aging, Senescence and Cancer
Dr. Kvell Krisztián
7 Cellular Effects of Acute and Chronic Stress
Dr. Kvell Krisztián
8 Metabolism and Longevity I
Dr. Kvell Krisztián
9 Metabolism and Longevity II
Dr. Kvell Krisztián
10 Senescence-related Intracellular Pathologies
Dr. Kvell Krisztián
11 Senescence-related Intracellular Pathologies
Dr. Kvell Krisztián
12 Molecular Mechanisms of Interventions
Dr. Kvell Krisztián
13 Invited Lecturer I
Dr. Kvell Krisztián
14 Invited Lecturer II
Dr. Kvell Krisztián
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Practices
Seminars
Exam topics/questions
MeetStreet
www.medbiotech.com
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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OPF-SSG-T HISTOLOGY SEMINAR FOR PHARMACY STUDENTS
Course director: DR. GABRIELLA HORVÁTH-OPPER, assistant professor
Department of Anatomy
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3
Number of hours/semester: 0 lectures + 0 practices + 28 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPO-AF-2 parallel
Topic
The aim of the subject is to complete the knowledge about structure of organ systems. Besides gross anatomy and basic histological
knowledge presented in mandatory anatomy courses, the ‘Histology seminars for pharmacy students’ offers better understanding of
histological background of physiological and oathophysiological processes and conditions.
Conditions for acceptance of the semester
The semestar can not be accepted over 2 absences.
Mid-term exams
Multimedia test on last seminar.
Making up for missed classes
Not possible.
Reading material
- Obligatory literature
- Literature developed by the Department
http://an-server.pote.hu
- Notes
- Recommended literature
Lectures
Practices
Seminars
1 Basic histotechnics
2 Skin of palm, skin of the armpit
3 Blood smear
4 Blood smear
5 Gastrointestinal tract I
6 Gastrointestinal tract II
7 Gastrointestinal tract III
8 Gastrointestinal tract IV
9 Gastrointestinal tract V
10 Gastrointestinal tract VI
11 Gastrointestinal tract VII
12 Respiratory system
13 Kidney
14 Female genital organs I
15 Female genital organs II
16 Female genital organs III
17 Male genitalia I
18 Male genitalia II
19 Endocrine glands I
20 Endocrine glands II
21 Endocrine glands III
22 Endocrine glands IV
23 Histology of the peripheral nervous system I
24 Histology of the peripheral nervous system II
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25 Eyebulb I
26 Eyebulb II
27 Test
28 Test
Exam topics/questions
http://an-server.pote.hu
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Füredi Nóra Judit (FUNQAAT.PTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
101
OPF-TG1-T STUDENT PROJECT RESEARCH FOR STUDENTS OF PHARMACEUTIST PROGRAMME 1
Course director: DR. GYÖRGYI HORVÁTH, associate professor
Department of Pharmacognosy
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3
Number of hours/semester: 0 lectures + 24 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 1 – 50 Prerequisites: none
Topic
The course aims at promoting of students to make student research projects on the field of pharmaceutical sciences. Furthermore, we
wish to give individual possibilities of students to perform experiments in the different pharmaceutical institutes involved into Students’
Research Society.
Conditions for acceptance of the semester
The continuous student’s work is recommended. The continuous enrollment of consecutive courses can be stopped and continued in
further semesters.
The prerequisite of this course (TDK 1): registration of the student in the database of Students’ Research Society.
Mid-term exams
TG1
Topic plan of student’s research project with the confirmation of supervisor
- Introduction of scientific articles found by the student in databases
- The topic plan and articles must be sent for course supervisor at the end of 13th week of the semester.
Making up for missed classes
There is no possibility.
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
ScienceDirect database
Lectures
Practices
1-24 Research.
Seminars
Exam topics/questions
Not applicable.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Horváth Györgyi (HOGAAA.T.JPTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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OPF-TMB-T MOLECULAR BIOLOGY OF TUMORS
Course director: DR. EDINA PANDUR, assistant professor
Department of Pharmaceutical Biology
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 3 – 30 Prerequisites: OPO-GB1 completed + OPO-GB2 completed
Topic
During the course we will discuss the molecular mechanisms of tumor development. We will deal with characteristic features of tumor
cells, and cancers. The function of influencing factors, risk factors, causes, the underlying molecular mechanisms, e.g. mutations, the
role of oncogenes and tumor-suppressor genes, DNA repair, epigenetics and the role of immune system will be discussed in detail. We
will emphasize the function of cell signaling pathways and the failure of apoptosis in tumorigenesis. We will speak about the molecular
mechanisms of invasion and metastasis of tumors, the genes and proteins which have a crucial role in these processes. The participants
will get an insight into the molecular diagnosis, genetic aberrations, and molecular alterations of human cancers. We will discuss the
possibilities for cancer therapies, the new approaches such as gene therapy and immunotherapy.
Conditions for acceptance of the semester
Max. 3 absences
Mid-term exams
One assay, one midterm exam.
Making up for missed classes
Personal consultation
Reading material
- Obligatory literature
- Literature developed by the Department
Educational materials will be uploaded to Neptune MeetStreet.
- Notes
- Recommended literature
Lauren Pecorino: Molecular Biology of Cancer
Wolfgang Arthur Schulz: Molecular Biology of Human Cancers
Lectures
1 Introduction to cancers: classification and characterization of cancers, causes of cancer, properties of cancer cells, principles of
therapies, targets of therapies
Dr. Pandur Edina
2 Introduction to cancers: classification and characterization of cancers, causes of cancer, properties of cancer cells, principles of
therapies, targets of therapies
Dr. Pandur Edina
3 Tumor genetics: mutations, carcinogenic agents, inheritance, tumor genes, defects in DNA repair and predispositions to cancer,
cell protection mechanisms
Dr. Pandur Edina
4 Tumor genetics: mutations, carcinogenic agents, inheritance, tumor genes, defects in DNA repair and predispositions to cancer,
cell protection mechanisms
Dr. Pandur Edina
5 Tumor epigenetics: mechanisms of epigenetic inheritance, imprinting, DNA methylation, epigenetics of cell differentiation and
tissue homeostasis
Poór Viktor Soma
6 Tumor epigenetics: mechanisms of epigenetic inheritance, imprinting, DNA methylation, epigenetics of cell differentiation and
tissue homeostasis
Poór Viktor Soma
7 Oncogenes and tumor-suppressor genes
Dr. Pandur Edina
8 Oncogenes and tumor-suppressor genes
Dr. Pandur Edina
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9 The cell cycle, apoptosis and senescence: checkpoints, therapeutic targets and inhibitors, molecular mechanisms of apoptosis,
replicative senescence and its disturbances in human cancers
Pap Ramóna
10 The cell cycle, apoptosis and senescence: checkpoints, therapeutic targets and inhibitors, molecular mechanisms of apoptosis,
replicative senescence and its disturbances in human cancers
Pap Ramóna
11 Signaling pathways in tumors: MAPK, PI3K, TP53 network, NFkappaB, TGFbeta, STAT signaling
Dr. Pandur Edina
12 Signaling pathways in tumors: MAPK, PI3K, TP53 network, NFkappaB, TGFbeta, STAT signaling
Dr. Pandur Edina
13 Invasion and metastasis: genes and proteins involved in cell-to-cell, cell-matrix adhesion, in extracellular matrix remodeling
during tumor invasion; angiogenesis.
Dr. Pandur Edina
14 Invasion and metastasis: genes and proteins involved in cell-to-cell, cell-matrix adhesion, in extracellular matrix remodeling
during tumor invasion; angiogenesis.
Dr. Pandur Edina
15 The role of immune system in tumors: inflammation, infections, cancer vaccines, inhibition of the immune system
Pap Ramóna
16 The role of immune system in tumors: inflammation, infections, cancer vaccines, inhibition of the immune system
Pap Ramóna
17 Stem cells and cancer: Wnt signaling, Hh signaling, differentiation therapy
Dr. Pandur Edina
18 Stem cells and cancer: Wnt signaling, Hh signaling, differentiation therapy
Dr. Pandur Edina
19 Cancer prevention: nutrients, energy metabolism of tumors, hormones and gene interactions
Pap Ramóna
20 Cancer prevention: nutrients, energy metabolism of tumors, hormones and gene interactions
Pap Ramóna
21 Diagnosis of tumors: molecular diagnosis, molecular detection and classification
Jánosa Gergely
22 Diagnosis of tumors: molecular diagnosis, molecular detection and classification
Jánosa Gergely
23 Human cancers I: common properties, genetic aberrations, molecular alterations, histology and etiology of cancers
Dr. Tóth Dénes
24 Human cancers I: common properties, genetic aberrations, molecular alterations, histology and etiology of cancers
Dr. Tóth Dénes
25 Human cancers II: common properties, genetic aberrations, molecular alterations, histology and etiology of cancers
Dr. Tóth Dénes
26 Human cancers II: common properties, genetic aberrations, molecular alterations, histology and etiology of cancers
Dr. Tóth Dénes
27 Drugs in cancer therapy: molecular mechanisms of cancer chemotherapy, targeted drug therapy, immunotherapy, gene therapy
Dr. Poór Miklós
28 Drugs in cancer therapy: molecular mechanisms of cancer chemotherapy, targeted drug therapy, immunotherapy, gene therapy
Dr. Poór Miklós
Practices
Seminars
Exam topics/questions
Simple choice test based on the lectures.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
104
OPE-BKM-T BASIC METHODS OF SCIENTIFIC RESEARCH
Course director: DR. ÁGNES FARKAS, associate professor
Department of Pharmacognosy
2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 14 lectures + 0 practices + 14 seminars = total of 28 hours
Course headcount limitations (min.-max.): 3 – 15 Prerequisites: OPA-B2E completed + OPA-B2G completed
Topic
The course aims at introducing students to the basic steps of scientific research, guiding them through stages of becoming an independent
researcher. The course covers each step of the research process, from preparing a research plant to evaluating and reporting data. Students
will become familiar with various methods of literature search, data collection, data analysis, as well as the ethical questions of scientific
research. Students will be introduced to various types of scientific works, including rules and requirements of scientific communication.
A session will be dedicated to the special requirements of writing a thesis. Emphasis will be laid on practice: in the seminars students
should put into practice what they have learned in the lectures, based on their own research work.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
The midsemester grade will be based on the successful completion of the above tasks.
Making up for missed classes
A pótlásra az órákon kiadott segédanyagok biztosítanak lehetőséget.
Reading material
- Obligatory literature
- Literature developed by the Department
Az órák anyaga elérhető a Farmakognóziai Intézet honlapján.
- Notes
- Recommended literature
Turabian K. L. (2010): A Manual for Writers of Research Papers, Theses, and Dissertations. Chicago Style for Students &
Researchers. 8th edition. The University of Chicago Press. Chicago and London, pp. 448.
Lectures
1 Concept, process and strategies of scientific research. Organising research projects. Research plan.
Dr. Farkas Ágnes
2 Methods of data collection. Questionnaires.
Dr. Farkas Ágnes
3 Literature search.
Dr. Farkas Ágnes
4 Designing experiments.
Dr. Farkas Ágnes
5 Data processing, data analysis.
Dr. Farkas Ágnes
6 Evaluation of data.
Dr. Farkas Ágnes
7 The role of informatics in scientific research.
Dr. Farkas Ágnes
8 The role of informatics in scientific research.
Dr. Farkas Ágnes
9 Ethical questions of scientific research.
Dr. Farkas Ágnes
10 Animal studies. Clinical studies.
Dr. Farkas Ágnes
11 Scientific communication. Types of scientific works. Metrics of scientific achievement.
Dr. Farkas Ágnes
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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12 Rules and requirements in scientific communication.
Dr. Farkas Ágnes
13 Writing applications for scholarships and research grants.
Dr. Farkas Ágnes
14 Scientific co-operations. Scene and institutions of science in Hungary.
Dr. Farkas Ágnes
Practices
Seminars
1 Preparing a research plan based on the student’s own research objectives.
2 Preparing a questionnaire.
3 Literature search in the field of the student’s own research I.
4 Literature search in the field of the student’s own research II.
5 Evaluation of data from the student’s research project I.
6 Evaluation of data from the student’s research project II.
7 Practice of scientific communication I.
8 Practice of scientific communication II.
9 Practice of scientific communication III.
10 Practice of scientific communication IV.
11 Practice of scientific communication V.
12 Practice of scientific communication VI.
13 Practice of writing an application for a scholarship I.
14 Practice of writing an application for a research project II.
Exam topics/questions
1. Research plan.
2. Methods of data collection.
3. Questionnaires.
4. Methods of literature search.
5. Methods of data analysis.
6. Critical evaluation of data.
7. Ethical questions of scientific research.
8. Animal studies. Clinical studies.
9. Scientific writing: types, rules and requirements.
10. References, bibliography.
11. Scene and institutions of science in Hungary.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Farkas Ágnes (FAADAB.T.JPTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
106
OPE-EMM-T MOLECULAR BASIS OF ENDOCRINE DISEASES
Course director: DR. MARIETTA VÉRTES M, professor emeritus
Institute of Physiology
2 credit ▪ midsemester grade ▪ Elective subject for the Medical/Biological module ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 50 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
Endocrinology is the study of hormones, their receptors and the intracellular signalling pathways they invoke. The aim of the program is
to understand the effects of hormones on cellular growth and function and their implications in development of endocrine dysfunction.
Explain the molecular and cellular abnormalities in common endocrine-based diseases.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Written exam, multiple choice questions from lectures
Making up for missed classes
Oral discussion of given chapter
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
Greenstein B.: Endocrinology at a Glance, Springer 1999
Williams Textbook of Endocrinology, 2004
Goodman M: Basic Medical Endocrinology, 2000
Greenspan FS, Baxter JD: Basic and Clinical Endocrinology, 2003
Lectures
1 Disorders of endocrine system. Hypo- and hyperfunction
Dr. Vértes M Marietta
2 Disorders of endocrine system. Hypo- and hyperfunction
Dr. Vértes M Marietta
3 Defect in sensitivity to hormones. Approach to the patient with endocrine disease
Dr. Vértes M Marietta
4 Defect in sensitivity to hormones. Approach to the patient with endocrine disease
Dr. Vértes M Marietta
5 Laboratory and imaging studies. Endocrinologic evaluation of the hypothalamo-pituitary axis
Dr. Vértes M Marietta
6 Laboratory and imaging studies. Endocrinologic evaluation of the hypothalamo-pituitary axis
Dr. Vértes M Marietta
7 Pituitary disorders: adenomas, Hypopitutarism, hypothalamic dysfunction.
Dr. Vértes M Marietta
8 Pituitary disorders: adenomas, Hypopitutarism, hypothalamic dysfunction.
Dr. Vértes M Marietta
9 Hormonal disorders of growth.
Dr. Vértes M Marietta
10 Hormonal disorders of growth.
Dr. Vértes M Marietta
11 Disorders of the thyroid
Dr. Vértes M Marietta
12 Disorders of the thyroid
Dr. Vértes M Marietta
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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13 Goiter. Hypothyroidism.
Dr. Vértes M Marietta
14 Goiter. Hypothyroidism.
Dr. Vértes M Marietta
15 Hyperthyroidism. Autoimmune disorders
Dr. Vértes M Marietta
16 Hyperthyroidism. Autoimmune disorders
Dr. Vértes M Marietta
17 Hormonal dysfunction of carbohydrate, protein and fat metabolism
Dr. Vértes M Marietta
18 Hormonal dysfunction of carbohydrate, protein and fat metabolism
Dr. Vértes M Marietta
19 Disorders of pancreas
Dr. Vértes M Marietta
20 Disorders of pancreas
Dr. Vértes M Marietta
21 Glucocorticoids, Adrenal medulla
Dr. Vértes M Marietta
22 Glucocorticoids, Adrenal medulla
Dr. Vértes M Marietta
23 Neural and hormonal integration in control of fluid homeostasis
Dr. Vértes M Marietta
24 Neural and hormonal integration in control of fluid homeostasis
Dr. Vértes M Marietta
25 Antidiuretic hormones, Mineral corticoids, Atrial Natriuretic Hormones
Dr. Vértes M Marietta
26 Antidiuretic hormones, Mineral corticoids, Atrial Natriuretic Hormones
Dr. Vértes M Marietta
27 Exam
Dr. Vértes M Marietta
28 Exam
Dr. Vértes M Marietta
Practices
Seminars
Exam topics/questions
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
108
OPE-GMO-T MODELLING THE STRUCTURE AND INTERACTIONS OF BIOACTIVE MOLECULES
Course director: DR. SÁNDOR KUNSÁGI MÁTÉ, associate professor
Department of Pharmaceutical Chemistry
2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ both semesters ▪ recommended semester: 4
Number of hours/semester: 17 lectures + 11 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 4 – 20 Prerequisites: none
Topic
In this course the basic examination methods of theoretical chemistry will be discussed by the practical point of view in the frame of
following subtopics: Methods of molecular modelling. Description of the forcefield, semiempirical, ab initio and density functional
methods, advantages and disadvantages. Discovering the balance between the model ant the calculation methods. The algorithm of the
choice of appropriate model and calculation method. Short description of the basic rules and mathematical background of theoretical
chemistry. calculation of the electronic structure of atoms and molecules. Calculation the equilibrium conformations of molecules, the
role of the entropy in the interactions of bioactive molecules and its calculation. Description of the correlation between the reactivity and
the temperature. Examples at molecular level. Considering the molecular environment: explicit and implicit methods. Interesting
examples and applications in pharmacy.
Conditions for acceptance of the semester
Mid-term exams
Two tests, each above 60 % is required for acceptance
Making up for missed classes
Upto 15% is allowed, electronical material is available
Reading material
- Obligatory literature
P.W. Atkins: Physical Chemistry
- Literature developed by the Department
- Notes
Slides and Summaries of lectures are available electronically
- Recommended literature
Jensen_F.-Introduction_to_Computational_Chemistry_(2007)
Scientific papers, list will be given during the lectures
Lectures
1 1 lecture Experimental results raise the necessity of quantum-chemical description of the structure of materials. Quantitization
and related quantities (energy, momentum, spin). Simple mathematical descriptions.
Dr. Kunsági Máté Sándor
2 1 lecture Experimental results raise the necessity of quantum-chemical description of the structure of materials. Quantitization
and related quantities (energy, momentum, spin). Simple mathematical descriptions.
Dr. Kunsági Máté Sándor
3 2 lecture Axiomatic description of the quantum theory. Atomic unit system. Overview on the exact and approximative solutions
of the time - independent Schrödinger equation.
Dr. Kunsági Máté Sándor
4 2 lecture Axiomatic description of the quantum theory. Atomic unit system. Overview on the exact and approximative solutions
of the time - independent Schrödinger equation.
Dr. Kunsági Máté Sándor
5 3 lecture Approximative solutions: the molecular mechanics methods.
Dr. Kunsági Máté Sándor
6 3 lecture Approximative solutions: the molecular mechanics methods.
Dr. Kunsági Máté Sándor
7 4 lecture Semi - empirical methods, advantages and disadvantages.
Dr. Kunsági Máté Sándor
9 5 lecture Conformation analysis, energy minimization algorithms.
Dr. Kunsági Máté Sándor
11 6 lecture Electronic structure of molecules. The chemical bonds, tipes of bonds. The structure of molecules, stereochemistry.
Dr. Kunsági Máté Sándor
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
109
13 7 lecture Modelling in comparison with the experiments, calculation of the enthalpy, entropy and their appropriate experimental
values.
Dr. Kunsági Máté Sándor
15 8 lecture Molecular symmetry, point groups and the symmetry of molecular vibrations.
Dr. Kunsági Máté Sándor
17 9 lecture Interactions of the primycin, ergosterol and oleic acid as plasma membrane unit.
Dr. Kunsági Máté Sándor
19 10 lecture Modelling the interactions of bioactive molecules with molecular containers in accordance with molecular packing of
drugs.
Dr. Kunsági Máté Sándor
21 11 lecture Quantum - chemical background of the rules in atomic and molecular spectroscopy. Rules of Raman and Infrared
transitions and their relationship with the molecular symmetry.
Dr. Kunsági Máté Sándor
23 12 lecture Effective calculation methods to consider the molecular environment: Onsager-model, Polarizable Continuum Model
Dr. Kunsági Máté Sándor
25 13 lecture Examples: simple chemical reactions, calculation of the stability weak molecular complexes, conformation analysis.
Dr. Kunsági Máté Sándor
27 14 lecture Examples: modelling the systems possessing high symmetry and infinite volume. Crystals and polymers.
Dr. Kunsági Máté Sándor
Practices
4 4 practice : Geometry optimization and conformation analysis. Energy minimization algorythm mostly used in geometry
optimization practice.
5 5 practice: Calculation of the static potential energy surfaces of chemical reactions. Methods to determine the transition states
associated to the chemical reactions. Activation energy and activation free enthalpy.
6 6 practice Molecular dynamics methods, Monte-Carlo method and the Langevin model. The implicite consideration of the
molecular environment.
7 7 practice Modelling the elementary chemical reactions. Calculation of molecular dynamics. Determination of the rection rate
using direct trajectory method.
8 8 practice Methods for consideration of the solvents: the Onsager-model, and the Polarizable Continuum Model, PCM. Explicit
consideration of the solvent molecules. The TIP3P model.
9 9 practice Calculation of molecular parameters have significant importance in the practice. The QSAR and the molecular
similarity - analysis.
10 10 practice Examples: conformation analysis, bong length, bond angle and dihedral angles. The bipyridile and thionine molecules.
Calixarenes and stereoisomers. Importance of hydrogen bonds in the stability of molecular geometries.
11 11 practice Examples: interactions of molecules. Calculation of the host - guest interactions, calculations of interactions of
calixarenes with neutral molecules based on pi-pi interactions.
12 12 practice Examples : elementary dissociation reactions: dissociation of asymmetric olefines. Effect of melecular environment
on the reaction rate.
13 13 practice Examples: Interaction of Primycin and oleic acid. Calculation of the interaction energy in system possessing large
numbers of electrons.
14 14 practice E+xamples: dynamic processes: modelling the crystal growth.
Seminars
Exam topics/questions
Methods of molecular modelling. Description of the forcefield, semiempirical, ab initio and density functional methods, avantages and
disadvantages. The balance between the model ant the calculation methods. The algorithm of the choice of appropriate model and
calculation method.Short description of the basic rules and mathematical background of theoretical chemistry. calculation of the
electronic structure of atoms and molecules. Calculation the equilibrium conformations of molecules, the role of the entropy in the
interactions of bioactive molecules and its calculation. Description of the correlation between the reactivity and the temperature.
Examples at moecular level. Considering the molecular environment: explicit and implicit methods. Interesting examples and
applications in pharmacy.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Kunsági Máté Sándor (KUSFAAP.PTE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
110
OPE-PPP-T PROTEINS AND PEPTIDES IN PHARMACOLOGY
Course director: DR. CSABA HETÉNYI, associate professor
Department of Pharmacology and Pharmacotherapy
2 credit ▪ midsemester grade ▪ Elective subject for the Pharmaceutical module ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 1 – 300 Prerequisites: none
Topic
The course describes the pharmacological role of proteins and peptides. The character and various functions of these biopolymers are
featured on the basis of structural considerations. Besides the usual discussion according to biochemical and physiological classifications,
an emphasis is placed on the introduction of the corresponding methodologies, as well. In Journal Club sessions, recent research articles
will be featured with the students to deepen their knowledge in the areas discussed during the previous lectures. In this way, the students
can discover further connections themselves and make sure of the usefulness of their newly obtained knowledge on proteins and peptides.
Conditions for acceptance of the semester
Jelenleg a választható és elektív kurzusok esetén a szabályzat nem tartalmaz részvételi követelményt. Amennyiben szükséges itt valamit
megjelölnöm, akkor 25 %, de csak azért teszem, hogy kitölthető legyen az űrlap. Javasoltam a Tanulmányi Bizottság vezetőjének a
helyzet szabályzását és 50 % mértéket a hiányzásoknál.
Mid-term exams
There is a final test announced at the end of the semester. The test will include multiple choice questions and short essays. A mark is
offered according to the results of the written test and optionally by evaluation of the student’s presentation prepared for the Journal
Club. The student can improve the mark according to university regulations.
Making up for missed classes
Replacement is possible according to personal consultation.
Reading material
- Obligatory literature
- Literature developed by the Department
The material of the course including pdfs of lectures and lists of questions will be made downloadable from the web site of the
Department of Pharmacology and Pharmacotherapy or a link will be provided during the lectures / in an e-mail.
- Notes
- Recommended literature
Lectures
1 General properties, building blocks, classification
Dr. Hetényi Csaba
2 Synthesis, purification, analysis
Dr. Hetényi Csaba
3 Structural properties
Dr. Hetényi Csaba
4 Structure determination methods
Dr. Hetényi Csaba
5 Structure and function 1. Peptides
Dr. Hetényi Csaba
6 Structure and function 2. Proteins
Dr. Hetényi Csaba
7 Stability, folding, flexibility
Dr. Hetényi Csaba
8 Molecular interactions
Dr. Hetényi Csaba
9 Endogenous peptides
Dr. Hetényi Csaba
10 Exogenous peptides, peptidomimetics
Dr. Hetényi Csaba
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11 Journal club 1. Experimental and computational structure determination
Dr. Hetényi Csaba
12 Journal club 2. Disordered proteins and pathological folds
Dr. Hetényi Csaba
13 Journal club 3. X-ray crystallography and NMR
Bálint Mónika Enikő
14 Journal club 4. Cryo-electronmicroscopy
Bálint Mónika Enikő
15 General properties of enzymes
Bálint Mónika Enikő
16 Inhibition
Bálint Mónika Enikő
17 Experimental methods of enzymology
Bálint Mónika Enikő
18 Computational methods of enzymology
Bálint Mónika Enikő
19 Membrane proteins, transporters
Bálint Mónika Enikő
20 Specialty drugs (biologics)
Bálint Mónika Enikő
21 Anti-cancer targets 1: proteins of signaling pathways
Bálint Mónika Enikő
22 Anti-cancer targets 2: structural and motor proteins
Bálint Mónika Enikő
23 Antiviral targets 1: enzymes
Bálint Mónika Enikő
24 Antiviral targets 2: structural proteins
Bálint Mónika Enikő
25 Journal club 5. Enzyme targets
Bálint Mónika Enikő
26 Journal club 6. Receptors, structural and motor protein targets
Bálint Mónika Enikő
27 Journal club 7. Molecular dynamics
Bálint Mónika Enikő
28 Journal club 8. Docking
Bálint Mónika Enikő
Practices
Seminars
Exam topics/questions
Lists of questions will be provided at the end of each lecture specifying the required knowledge.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
112
OPE-SME-T SPECTROMETRIC IDENTIFICATION OF ORGANIC COMPOUNDS
Course director: DR. CECÍLIA PÁPAY- SÁR, associate professor
Department of Organic and Pharmacological Chemistry
2 credit ▪ midsemester grade ▪ Elective subject for the Pharmaceutical module ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 2 – 10 Prerequisites: OPA-SV1 completed
Topic
The aim of this course is to introduce the students how to identify organic compounds from the complementary information afforded by
three types of spectra: infrared, mass and NMR.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
The student who has been absent from more than 25 % of the classes cannot be granted to entry of exam.
Making up for missed classes
Students can personally consult with the lecturer.
Reading material
- Obligatory literature
Silverstein, R.M., Webster, F.X., Kiemle, D.: Spectrometric Identification of Organic Compounds, John Wiley and Sons, 2005.
- Literature developed by the Department
- Notes
- Recommended literature
Lectures
1 Infrared Spectroscopy: Introduction, theory, instrumentation, interpretation of spectra.
Dr. Pápayné Dr. Sár Cecília
2 Infrared Spectroscopy: Introduction, theory, instrumentation, interpretation of spectra
Dr. Pápayné Dr. Sár Cecília
3 Infrared Spectroscopy: Characteristic group absorptions of organic molecules
Dr. Pápayné Dr. Sár Cecília
4 Infrared Spectroscopy: Characteristic group absorptions of organic molecules
Dr. Pápayné Dr. Sár Cecília
5 Infrared Spectroscopy: Solving problems
Dr. Pápayné Dr. Sár Cecília
6 Infrared Spectroscopy: Solving problems
Dr. Pápayné Dr. Sár Cecília
7 Proton Magnetic Resonance Spectrometry (1H NMR): Introduction, theory, instrumentation.
Dr. Pápayné Dr. Sár Cecília
8 Proton Magnetic Resonance Spectrometry (1H NMR): Introduction, theory, instrumentation
Dr. Pápayné Dr. Sár Cecília
9 1H NMR: Chemical shift, simple spin coupling
Dr. Pápayné Dr. Sár Cecília
10 1H NMR: Chemical shift, simple spin coupling
Dr. Pápayné Dr. Sár Cecília
11 1H NMR: Protons on heteroatoms, chemical shift equivalence and magnetic equivalence, effects of a chiral center.
Dr. Pápayné Dr. Sár Cecília
12 1H NMR: Protons on heteroatoms, chemical shift equivalence and magnetic equivalence, effects of a chiral center.
Dr. Pápayné Dr. Sár Cecília
13 13 C NMR Spectroscopy: Interpretation of 13 C spectra. The principles of MRI.
Dr. Pápayné Dr. Sár Cecília
14 13 C NMR Spectroscopy: Interpretation of 13 C spectra. The principles of MRI
Dr. Pápayné Dr. Sár Cecília
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15 1H NMR and 13 C NMR: Solving problems
Dr. Pápayné Dr. Sár Cecília
16 1H NMR and 13 C NMR: Solving problems
Dr. Pápayné Dr. Sár Cecília
17 Mass Spectrometry: Mass spectrometer parts, ionization processes
Dr. Kálai Tamás
18 Mass Spectrometry: Mass spectrometer parts, ionization processes
Dr. Kálai Tamás
19 Mass Spectrometry: Appearance of the mass spectrum, mass spectra of classes of organic compounds.
Dr. Kálai Tamás
20 Mass Spectrometry: Appearance of the mass spectrum, mass spectra of classes of organic compounds
Dr. Kálai Tamás
21 Mass Spectrometry: Interpretation of the mass spectrum through examples.
Dr. Kálai Tamás
22 Mass Spectrometry: Interpretation of the mass spectrum through examples.
Dr. Kálai Tamás
23 Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra.
Dr. Pápayné Dr. Sár Cecília
24 Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra.
Dr. Pápayné Dr. Sár Cecília
25 Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra.
Dr. Pápayné Dr. Sár Cecília
26 Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra.
Dr. Pápayné Dr. Sár Cecília
27 Evaluation, written exam
Dr. Pápayné Dr. Sár Cecília
28 Evaluation, written exam
Dr. Pápayné Dr. Sár Cecília
Practices
Seminars
Exam topics/questions
Infrared Spectroscopy: theory, instrumentation, interpretation of spectra, chacteristic group absorptions of organic molecules.
Proton Magnetic Resonance Spectrometry (1H NMR): theory, instrumentation, chemical shift, simple spin coupling, protons on
heteroatoms, chemical shift equivalence and magnetic equivalence, effects of a chiral center.
Mass Spectrometry: mass spectrometer parts, ionization processes, appearance of the mass spectrum, mass spectra of classes of organic
compounds.
Identification of simple organic molecules from IR, NMR and mass spectra.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPE-TIZ-T CENTRAL REGULATION OF FEEDING AND METABOLISM. NEW APPROACHES
Course director: DR. ZOLTÁN KARÁDI, professor
Institute of Physiology
1 credit ▪ midsemester grade ▪ Elective subject for the Medical/Biological module ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 2 – 25
Prerequisites: OPO-A2S completed + OPO-EN1 completed + OPA-G1B parallel
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The high incidence and costs of eating and metabolic disorders make it indispensable to experimentally test new theoretical
considerations, and to employ their conclusive results in basically new clinical protocols. Students at early stage of their studies are, thus,
encouraged to familiarize with new theoretical aspects and experimental findings.
Neural and humoral mechanisms in the central feeding control and metabolic regulation. Body weight control in health and disease.
Peripheral and central taste information processing; gustation in the central regulation of food and fluid intake. Obesity, diabetes mellitus
and the metabolic syndrome: New interpretations.
Conditions for acceptance of the semester
According to general regulations
Mid-term exams
Making up for missed classes
Individually discussed
Reading material
- Obligatory literature
Guyton & Hall: Textbook of Medical Physiology, Saunders
- Literature developed by the Department
- Notes
- Recommended literature
Williams and Pickup: Handbook of Diabetes, Blackwell
Doty: Handbook of Olfaction and Gustation, Marcel Dekker
Lectures
1 Physiological significance of food and fluid intake, and metabolism.
Dr. Karádi Zoltán
2 Homeostasis, motivation.
Dr. Karádi Zoltán
3 Neuronal and humoral factors in the central regulation of homeostatic functions: brain centers, neurotransmitter pathways,
neuropeptides. I
Dr. Karádi Zoltán
4 Neuronal and humoral factors in the central regulation of homeostatic functions: brain centers, neurotransmitter pathways,
neuropeptides. II
Dr. Karádi Zoltán
5 Neuronal and humoral factors in the central regulation of homeostatic functions: brain centers, neurotransmitter pathways,
neuropeptides. III
Dr. Karádi Zoltán
6 Exogenous chemosensory modalities. Physiologic roles of gustation.
Dr. Karádi Zoltán
7 Central taste pathways, „labeled lines”, neurons.
Dr. Karádi Zoltán
8 Taste preference, taste aversion, palatability, flavour.
Dr. Karádi Zoltán
9 The glucose-monitoring (GM) neural network. I
Dr. Karádi Zoltán
10 The glucose-monitoring (GM) neural network. II
Dr. Karádi Zoltán
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11 The glucose-monitoring (GM) neural network. III
Dr. Karádi Zoltán
12 Eating and metabolic disorders: obesity, anorexia nervosa, diabetes mellitus, metabolic syndrome. I
Dr. Karádi Zoltán
13 Eating and metabolic disorders: obesity, anorexia nervosa, diabetes mellitus, metabolic syndrome. II
Dr. Karádi Zoltán
14 Feeding and metabolic disorders: disturbance of the GM system?
Dr. Karádi Zoltán
Practices
Seminars
Exam topics/questions
According to topics of the lectures
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPF-CSU-T MIRACLES OF LIVING MATERIALS ("REALISTIC" BIOCHEMISTRY)
Course director: DR. BALÁZS VERES, associate professor
Department of Biochemistry and Medical Chemistry
1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 0 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The aim of the course is to enlighten and uncover the biochemical background of those topics which are selected as recent „mainstream”
natural science issues. The topic spectrum is wide enough to cover problems from synthetic biology through dopes in sport until toxins
and poisons of plants, fungi and animals. There is a special session about the physical, chemical and medical Nobel prizes from the last
decade to get insight to the hottest fields of natural sciences.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
-
Making up for missed classes
There is no possibility to make up.
Reading material
- Obligatory literature
- Literature developed by the Department
Lecture slides (in pdf format) will be available for the students. WEB links and additional on line materials will be included as well.
- Notes
Lecture slides (in pdf format) will be available for the students. WEB links and additional on line materials will be included as well.
- Recommended literature
Lecture slides (in pdf format) will be available for the students. WEB links and additional on line materials will be included as well.
Lectures
1 Human genome project, gene therapy, epigenetics
Dr. Veres Balázs
2 DNA sequencing, PCR, CSI
Dr. Veres Balázs
3 Playing God: synthetic biology
Dr. Veres Balázs
4 You are what you eat: GMO
Dr. Veres Balázs
5 Superman: doping in sport and brain doping
Dr. Veres Balázs
6 Dependence: biochemistry of alcohol and drugs
Dr. Veres Balázs
7 Falling down: apoptosis, necrosis, autophagy
Dr. Veres Balázs
8 Cancer, AIDS: beyond therapy
Dr. Veres Balázs
9 Biochemistry of neurodegenerative disorders
Dr. Veres Balázs
10 Antibiotics: past, present, future
Dr. Veres Balázs
11 Home delivery: nanoparticles, liposomes
Dr. Veres Balázs
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12 Nature strikes back: toxins of plants, fungi and animals
Dr. Veres Balázs
13 Ideas behind Nobel prizes I
Dr. Veres Balázs
14 Ideas behind Nobel prizes II
Dr. Veres Balázs
Practices
Seminars
Exam topics/questions
Exam topics are the topics of the lectures during the course.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPF-GMI-T GYÓGYSZERÉSZEK A MINDENNAPOKBAN - ANGOL VÁLTOZAT
Course director: DR. ÁGNES FARKAS, associate professor
Department of Pharmacognosy
1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 3 – 30 Prerequisites: none
Topic
This course intends to provide insight into various career opportunities for graduates with a degree in pharmacy. Invited speakers working
in various fields of the pharmaceutical professsion talk about characteristic features of their job, including daily routine, challenging
situations and peculiarities they have come accross. Speakers represent pharmacists working in community pharmacies, clinical
pharmacies, in the pharmaceutical industry, as well as at health authorities and at universities or research institutes.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
Active participation is expected from students. They should be prepared to ask questions from each speaker and they are requested to
take notes on each occasion. These notes should be handed in to the course instructor at the end of each class.
The final grade is based on students’ activity in class and the written notes they have taken on each occassion.
Making up for missed classes
There is no opportunity to make up for absences, since different speakers are invited to each class.
Reading material
- Obligatory literature
None
- Literature developed by the Department
- Notes
- Recommended literature
Lectures
1 Invited speaker. Pharmacist at a community pharmacy.
2 Invited speaker. Pharmacist at a community pharmacy.
3 Invited speaker. Pharmacist at a clinical pharmacy.
4 Invited speaker. Pharmacist at a clinical pharmacy.
5 Invited speaker. Pharmacist working in the pharmaceutical industry.
6 Invited speaker. Pharmacist working in the pharmaceutical industry.
7 Invited speaker. Pharmacist working at a university.
8 Invited speaker. Pharmacist working at a university.
9 Invited speaker. Pharmacist working in a research institute.
10 Invited speaker. Pharmacist working in a research institute.
11 Invited speaker. Pharmacist working at the health authorities.
12 Invited speaker. Pharmacist working at the health authorities.
13 Invited speaker. Daily routine of a specialty pharmacist.
14 Invited speaker. Daily routine of a specialty pharmacist.
Practices
Seminars
Exam topics/questions
No exam questions.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPF-H4A-T MEDICAL HUNGARIAN 4A - BASICS OF MEDICAL COMMUNICATION FOR STUDENTS OF
PHARMACY
Course director: DR. GÁBOR RÉBÉK-NAGY, associate professor
Department of Languages for Specific Purposes
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 0 lectures + 28 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPF-H3A completed + OPF-H4B parallel
Topic
This course provides language and communicative functions in the areas of medications, the application of medications and prescribing
medications and is also meant to give opportunities for putting skills and knowledge into practice in preparation for the final exam.
Conditions for acceptance of the semester
Participation in class work is obligatory. In case absences exceed 25% of total class time, the course will be regarded as uncompleted. In
the case of absences up to 25% of total class time, oral examination will have to be taken
Mid-term exams
-
Making up for missed classes
Reading material
- Obligatory literature
- Literature developed by the Department
Hand-outs
- Notes
- Recommended literature
Lectures
Practices
1 Types and forms of medications - Review
2 Application of medications - Review
3 Instructions concerning the use of medications: painkillers
4 Instructions concerning the use of medications: painkillers
5 Instructions concerning the use of medications: antipyretics
6 Instructions concerning the use of medications: cough medications
7 Instructions concerning the use of medications: antidiabetics
8 Instructions concerning the use of medications: spasmolytics
9 Instructions concerning the use of medications: sleeping pills
10 Instructions concerning the use of medications: steroids
11 Instructions concerning the use of medications: antibiotics
12 Instructions concerning the use of medications: antiinlammatory medications
13 Instructions concerning the use of medications: emetics and aniemetics
14 Instructions concerning the use of medications: eye, ear and nasal drops
15 Instructions concerning the use of medications: medications applied to the skin
16 Test 1
17 Instructions concerning the use of medications: suppository
18 First aid instruments
19 Preparation for the Final Exam in Medical Hungarian
20 Preparation for the Final Exam in Medical Hungarian
21 Preparation for the Final Exam in Medical Hungarian
22 Preparation for the Final Exam in Medical Hungarian
23 Preparation for the Final Exam in Medical Hungarian
24 Preparation for the Final Exam in Medical Hungarian
25 Preparation for the Final Exam in Medical Hungarian
26 Preparation for the Final Exam in Medical Hungarian
27 Test 2
28 Course evaluation
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Seminars
Exam topics/questions
-
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Hegedűs Anita (HEAAAA.B.JPTE), Dr. Rébék-Nagy Gábor (REGCAC.B.JPTE), Dr. Warta Vilmos (WAVEAB.B.JPTE), Eklicsné
Dr. Lepenye Katalin (EKLAXA.B.JPTE), Hamarné Sávay Judit (HASMAAO.PTE), Hild Gabriella (MAGAAD.B.JPTE), Horváth Lilla
Anita (HOLFABP..PTE), Kurdiné Molnár Eszter (KUMPAAK.PTE), Lokodiné Szolcsányi Judit (LOSIAAB.PTE), Mészégetőné
Halmos Éva (MEHHABE.PTE), Móriczné Győrffy Mária (MOGPAAP.PTE), Nagy Gabriella (NAGMAAO.PTE), Ronczykné Berta
Anikó (BEAAAI.B.JPTE), Szántóné Dr. Csongor Alexandra (CSAAAA.B.JPTE), Váradi Katalin (VAKHAAE.PTE)
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OPF-H4B-T MEDICAL HUNGARIAN 4B - MEDICAL COMMUNICATION IN PRACTICE FOR STUDENTS OF
PHARMACY
Course director: DR. GÁBOR RÉBÉK-NAGY, associate professor
Department of Languages for Specific Purposes
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 0 lectures + 28 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPF-H3B completed + OPF-H4A parallel
Topic
This course provides language and communicative functions in the areas of medications, the application of medications and prescribing
medications and is also meant to give opportunities for putting skills and knowledge into practice in preparation for the final exam.
Conditions for acceptance of the semester
Participation in class work is obligatory. In case absences exceed 25% of total class time, the course will be regarded as uncompleted. In
the case of absences up to 25% of total class time, oral examination will have to be taken.
Mid-term exams
Making up for missed classes
Reading material
- Obligatory literature
- Literature developed by the Department
Hand-outs
- Notes
- Recommended literature
Lectures
Practices
1 Types and forms of medications - Review
2 Application of medications - Review
3 Instructions concerning the use of medications: painkillers - Pharmacist-patient dialogue
4 Instructions concerning the use of medications: painkillers - Pharmacist-patient dialogue
5 Instructions concerning the use of medications: antipyretics - Pharmacist-patient dialogue
6 Instructions concerning the use of medications: cough medications - Pharmacist-patient dialogue
7 Instructions concerning the use of medications: antidiabetics - Pharmacist-patient dialogue
8 Instructions concerning the use of medications: spasmolytics - Pharmacist-patient dialogue
9 Instructions concerning the use of medications: sleeping pills - Pharmacist-patient dialogue
10 Instructions concerning the use of medications: steroids - Pharmacist-patient dialogue
11 Instructions concerning the use of medications: antibiotics - Pharmacist-patient dialogue
12 Instructions concerning the use of medications: antiinlammatory medications - Pharmacist-patient dialogue
13 Instructions concerning the use of medications: emetics and antiemetics - Pharmacist-patient dialogue
14 Instructions concerning the use of medications: eye, ear and nasal drops - Pharmacist-patient dialogue
15 Instructions concerning the use of medications: medications applied to the skin - Pharmacist-patient dialogue
16 Test 1
17 Instructions concerning the use of medications: suppository - Pharmacist-patient dialogue
18 First aid instruments -Listening comprehension and speaking skills
19 Preparation for the Final Exam in Medical Hungarian
20 Preparation for the Final Exam in Medical Hungarian
21 Preparation for the Final Exam in Medical Hungarian
22 Preparation for the Final Exam in Medical Hungarian
23 Preparation for the Final Exam in Medical Hungarian
24 Preparation for the Final Exam in Medical Hungarian
25 Preparation for the Final Exam in Medical Hungarian
26 Preparation for the Final Exam in Medical Hungarian
27 Test 2
28 Course evaluation
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Seminars
Exam topics/questions
-
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Hegedűs Anita (HEAAAA.B.JPTE), Dr. Rébék-Nagy Gábor (REGCAC.B.JPTE), Dr. Warta Vilmos (WAVEAB.B.JPTE), Eklicsné
Dr. Lepenye Katalin (EKLAXA.B.JPTE), Hamarné Sávay Judit (HASMAAO.PTE), Hild Gabriella (MAGAAD.B.JPTE), Horváth Lilla
Anita (HOLFABP..PTE), Kurdiné Molnár Eszter (KUMPAAK.PTE), Lokodiné Szolcsányi Judit (LOSIAAB.PTE), Mészégetőné
Halmos Éva (MEHHABE.PTE), Móriczné Győrffy Mária (MOGPAAP.PTE), Nagy Gabriella (NAGMAAO.PTE), Ronczykné Berta
Anikó (BEAAAI.B.JPTE), Szántóné Dr. Csongor Alexandra (CSAAAA.B.JPTE), Váradi Katalin (VAKHAAE.PTE)
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OPF-MAS-T INSTRUMENTAL ANALYSIS - SEMINAR
Course director: DR. TÍMEA DERGEZ, assistant professor
Institute of Bioanalysis
1 credit ▪ midsemester grade ▪ Optional subject ▪ both semesters ▪ recommended semester: 4
Number of hours/semester: 0 lectures + 0 practices + 14 seminars = total of 14 hours
Course headcount limitations (min.-max.): 1 – 0 Prerequisites: none
Topic
The seminars will be available for helping the students in their studies in Instrumental analysis - both theory and practice.
Conditions for acceptance of the semester
According to the Faculty rules.
Mid-term exams
-
Making up for missed classes
-
Reading material
- Obligatory literature
- Literature developed by the Department
Material can be downloaded from the website of the Institute of Bioanalysis under the
Educational materials link: http://aok.pte.hu/en/egyseg/oktatas/160 (the username and password
are provided in the lectures).
Instrumental Analysis. Laboratory Practice. DOI: 10.15170/TTK.2014.00001 (dowloadable by the DOI number).
- Notes
- Recommended literature
D.A. Skoog, F.J. Holler, S.R. Crouch: Principles of Instrumental Analysis
D.G. Watson: Pharmaceutical Analysis, Elsevier
Lectures
Practices
Seminars
1 Potentiometry
2 Conductometry
3 Atomspectroscopy
4 Molecular spectroscopy
5 Infrared spectroscopy
6 Nuclear magnetic resonance spectroscopy
7 Separation techniques in general
8 Gas-chromatography
9 Liquid chromatography
10 Electrophoretic techniques
11 Capillary electrophoresis
12 Mass spectrometry
13 Coupled separation techniques
14 Data evaluation and error calculation
Exam topics/questions
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Dergez Tímea (DETCAA.T.JPTE), Dr. Kilár Ferenc (KIFGAAO.PTE), Dr. Poór Viktória (POVAAA.T.JPTE), Páger Csilla
(PACMAAO.PTE)
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OPF-MMR-T NUCLEAR MAGNETIC RESONANCE FOR DUMMIES
Course director: DR. ZOLTÁN BERENTE, associate professor
Department of Biochemistry and Medical Chemistry
1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 1 – 20 Prerequisites: OPA-AN2 completed + OPA-BA1 completed
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
Nuclear magnetic resonance offers an exceptionally versatile, non-invasive and non-destructive way for studying intact living organisms.
However, magnetic resonance imaging (MRI), and especially NMR spectroscopy, are strikingly underrepresented among diagnostic
methods. It may be due to regarding the method a strange, obscure if not suspicious „black box”; this way of thinking is far more
widespread among graduated medical doctors than it should be.
Take the courage, the time and the effort to take a closer look at nuclear magnetic resonance. Let’s start from scratch and let’s understand
what your fellow students do not bother to understand: what happens with the sample in the magnet during an NMR or MRI experiment,
how does it happen and why.
The course covers the theoretical background of the medical diagnostic (imaging and biomarkers) and drug industrial (drug development,
drug analysis) applications of nuclear magnetic resonance with a problem-based attitude and case studies.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
The student is expected to present a project.
Making up for missed classes
On the judgement of the instructor.
Reading material
- Obligatory literature
http://cis.rit.edu/htbooks/nmr
http://cis.rit.edu/htbooks/mri
- Literature developed by the Department
- Notes
- Recommended literature
R. A. de Graaf: In vivo NMR Spectroscopy, Wiley, 1998
http://www.imaios.com/en/e-Courses/e-MRI
http://www.magnetic-resonance.org/
http://eprints.drcmr.dk/37/1/MRI_English_a4.pdf
Lectures
1 The NMR phenomenon. Excitation, relaxation and signal formation
Dr. Berente Zoltán
2 Fourier-transform pulse NMR: Theory and practice
Dr. Berente Zoltán
3 Structure elucidation of small molecules 1. One-dimensional techniques based on coupling through chemical bonds or through
the space.
Dr. Berente Zoltán
4 Structure elucidation of small molecules 2. NMR in more dimensions, strategy of structure analysis
Dr. Berente Zoltán
5 Structure elucidation of small molecules 3. NMR in drug development and in drug analysis
Dr. Berente Zoltán
6 Structure elucidation of macromolecules. Intramolecular and intermolecular interactions, structure-activity relationship
Dr. Berente Zoltán
7 Study of energy metabolism using 31P NMR spectroscopy
Dr. Berente Zoltán
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8 Study of fuel metabolism using 13C NMR spectroscopy
Dr. Berente Zoltán
9 Applications of NMR spectroscopy of other nuclei (19F, 23Na, 87Rb) in life sciences
Dr. Berente Zoltán
10 Statistical NMR spectroscopy: searching for biomarkers
Dr. Berente Zoltán
11 Basics of MR imaging
Dr. Berente Zoltán
12 Current MR imaging techniques
Dr. Berente Zoltán
13 Localised (volume selective) NMR spectroscopy
Dr. Berente Zoltán
14 NMR in solid phase: study of biological membranes
Dr. Berente Zoltán
Practices
Seminars
Exam topics/questions
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPF-QBI-T QUANTUM BIOLOGY: QUANTUM PHENOMENA IN BIOLOGICAL PROCESSES
Course director: DR. KRISZTIÁN KVELL, associate professor
Department of Pharmaceutical Biotechnology
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 3 – 50 Prerequisites: OPO-GB2-T completed
Topic
Course description:
Based on common scientific approach quantum phenomena are not relevant in biological processes. The living cell has relatively large
dimensions, is filled with hydrated vibrating macromolecules, and follows the rules thermodynamics rather than quantum mechanics.
Yet, besides attractive theories, experimental data also accumulate suggesting that living cells readily exploit quantum phenomena.
Several biological processes require quantum biology approach for full understanding. These include photosynthesis, various enzyme
activities, DNA mutation accumulation, avian magnetoreception, mammalian olfaction etc. During the course students get familiar with
the quantum biology explanation of these biological processes.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
There will be several occasions for the students to rewrite midterm tests.
Making up for missed classes
Students will get e-learning material to cope to follow the course at home.
Reading material
- Obligatory literature
Life on the edge: The coming of age of quantum biology
Johnjoe McFadden, Jim Al-Khalili
Broadway Books (2016) 368 pages
ISBN-13: 978-0307986825
- Literature developed by the Department
Topics:
- Quantum phenomena and basics terms
- Thermodynamics vs quantum mechanics
- Structural characteristics of biological macromolecules
- Quantum biology approach of the living cell
- Quantum biology approach of cell death
- Quantum biology approach of molecular energy transport
- Quantum biology approach of genetic mutation accumulation
- Quantum biology approach of photosynthesis
- Quantum biology approach of enzyme activity
- Quantum biology approach of avian magnetoreception
- Quantum biology approach of mammalian olfaction
- Quantum biology approach of the conscious mind
- Basic principles of quantum computers and quantum biology analogies
- Written exam
- Notes
Life on the edge: The coming of age of quantum biology
Johnjoe McFadden, Jim Al-Khalili
Broadway Books (2016) 368 pages
ISBN-13: 978-0307986825
- Recommended literature
Life on the edge: The coming of age of quantum biology
Johnjoe McFadden, Jim Al-Khalili
Broadway Books (2016) 368 pages
ISBN-13: 978-0307986825
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127
Lectures
1 Quantum phenomena and basics terms I.
Dr. Lukács András Szilárd
2 Quantum phenomena and basics terms II.
Dr. Lukács András Szilárd
3 Thermodynamics vs quantum mechanics I.
Dr. Lukács András Szilárd
4 Thermodynamics vs quantum mechanics II.
Dr. Lukács András Szilárd
5 Structural characteristics of biological macromolecules I.
Dr. Kvell Krisztián
6 Structural characteristics of biological macromolecules II.
Dr. Kvell Krisztián
7 Quantum biology approach of the living cell I.
Dr. Ábrahám István Miklós
8 Quantum biology approach of the living cell II.
Dr. Ábrahám István Miklós
9 Quantum biology approach of cell death I.
Dr. Ábrahám István Miklós
10 Quantum biology approach of cell death II.
Dr. Ábrahám István Miklós
11 Quantum biology approach of molecular energy transport I.
Dr. Pál Szilárd
12 Quantum biology approach of molecular energy transport II.
Dr. Pál Szilárd
13 Quantum biology approach of genetic mutation accumulation I.
Dr. Kvell Krisztián
14 Quantum biology approach of genetic mutation accumulation II.
Dr. Kvell Krisztián
15 Written exam
Dr. Kvell Krisztián
16 Quantum biology approach of photosynthesis I.
Dr. Hoffmann Gyula
17 Quantum biology approach of photosynthesis II.
Dr. Hoffmann Gyula
18 Quantum biology approach of enzyme activity I.
Dr. Pál Szilárd
19 Quantum biology approach of enzyme activity II.
Dr. Pál Szilárd
20 Quantum biology approach of avian magnetoreception I.
Dr. Hoffmann Gyula
21 Quantum biology approach of avian magnetoreception II.
Dr. Hoffmann Gyula
22 Quantum biology approach of mammalian olfaction I.
Dr. Hoffmann Gyula
23 Quantum biology approach of mammalian olfaction II.
Dr. Hoffmann Gyula
24 Quantum biology approach of the conscious mind I.
Dr. Sik Attila Gábor
25 Quantum biology approach of the conscious mind II.
Dr. Sik Attila Gábor
26 Basic principles of quantum computers and quantum biology analogies I.
Dr. Kvell Krisztián
27 Basic principles of quantum computers and quantum biology analogies II.
Dr. Kvell Krisztián
28 Written exam
Dr. Kvell Krisztián
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Practices
Seminars
Exam topics/questions
https://www.dropbox.com/home/munka/Kvantumbiológia?preview=LifeOnTheEdge2014.pdf
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Ábrahám István Miklós (ABIUAAP.PTE), Dr. Hoffmann Gyula (HOGFABP.PTE), Dr. Kvell Krisztián (KVKFAAO.PTE), Dr.
Lukács András Szilárd (LUATAA0.PTE), Dr. Miskei György Zsolt (MIGUAA0.PTE), Dr. Pál Szilárd (PASMAAO.PTE), Dr. Sik Attila
Gábor (A12OXW)
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OPF-SKI-T BASICS OF CHEMICAL INFORMATICS
Course director: DR. GYŐZŐ KORNÉL KULCSÁR, assistant professor
Department of Pharmaceutical Chemistry
1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 3 – 15 Prerequisites: OPA-SV1-T completed
Topic
The aim of the course is to give the students a basic knowledge of chemical informatics. An overview of how computers have become
the indispensable tools for chemical experiments, measurements, regulatory and performance evaluation tasks, and theoretical chemistry
tests.
We cover the chemical sciences from used software, web resources, which we believe are most useful during academic years in chemical
science student work and in preparing theses. Students can learn the basics of molecular modeling, the use of databases available in the
University (ScienceDirect, PubMed, SciFinder ...), the general steps of the search.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation in the lectures is obligatory.
Maximum three absences can be accepted.
Making up for missed classes
There is no opportunity to make up missed classes.
Reading material
- Obligatory literature
- Literature developed by the Department
The worksheets will be handed on the seminars.
- Notes
- Recommended literature
https://docs.chemaxon.com/display/docs/MarvinSketch+User%27s+Guide
http://www.cambridgesoft.com/support/DesktopSupport/Documentation/Manuals/files/chemdraw_9_english.pdf
Lectures
1 Introduction, simple database managers (literature, citations, etc.) in chemistry.
Dr. Kulcsár Győző Kornél
2 Introduction into the Molecular Modeling Software’s
Dr. Kulcsár Győző Kornél
3 Molecular modeling - structural fundamentals
Dr. Kulcsár Győző Kornél
4 Molecular modeling - structure optimization
Dr. Kulcsár Győző Kornél
5 Molecular modeling - molecules and interaction with the surroundings
Dr. Kulcsár Győző Kornél
6 Molecular modeling - molecular Interactions
Dr. Kulcsár Győző Kornél
7 Molecular modeling - applied modeling in drug research
Dr. Kulcsár Győző Kornél
8 Chemical databases I.
Dr. Kulcsár Győző Kornél
9 Chemical databases II.
Dr. Kulcsár Győző Kornél
10 Using a text editor application in chemistry
Dr. Kulcsár Győző Kornél
11 Handling bibliography
Dr. Kulcsár Győző Kornél
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12 Apply a spreadsheet program in chemistry
Dr. Kulcsár Győző Kornél
13 Apply a vector drawing program. Creating a flowchart of science, chemical content and flow charts. Photos and videos in
chemistry, the basics of image processing.
Dr. Kulcsár Győző Kornél
14 Presentation of student results, evaluation of the semester
Dr. Kulcsár Győző Kornél
Practices
Seminars
Exam topics/questions
Written test covering the topics of the lectures.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPF-TG2-T STUDENT PROJECT RESEARCH FOR STUDENTS OF PHARMACEUTIST PROGRAMME 2
Course director: DR. GYÖRGYI HORVÁTH, associate professor
Department of Pharmacognosy
2 credit ▪ midsemester grade ▪ Optional subject for the G module ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 0 lectures + 24 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPF-TG1 completed
Topic
The course aims at promoting of students to make student research projects on the field of pharmaceutical sciences. Furthermore, we
wish to give individual possibilities of students to perform experiments in the different pharmaceutical institutes involved into Students’
Research Society.
Conditions for acceptance of the semester
The continuous student’s work is recommended. The continuous enrollment of consecutive courses can be stopped and continued in
further semesters.
The prerequisite of this course (TDK 2): registration of the student in the database of Students’ Research Society and the fulfillment of
the Student Project Research for Students of Pharmaceutist Programme 1 course.
Mid-term exams
TG2
- Introduction of conference abstract or conference manuscript (student is co-author) for the course supervisor at the end of 13th week of
the semester.
- Written report on the work performed by the student. It must be sent to the course supervisor at the end of 13th week of the semester.
- Among the two conditions, one of them should be made at least.
Making up for missed classes
There is no possibility.
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
ScienceDirect database
Lectures
Practices
1-24 Research.
Seminars
Exam topics/questions
Not applicable.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Horváth Györgyi (HOGAAA.T.JPTE)
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OPF-VAA-T IRON METABOLISM: FROM MOLECULAR MECHANISMS TO CLINICAL CONSEQUENCES
Course director: DR. EDINA PANDUR, assistant professor
Department of Pharmaceutical Biology
1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 0 lectures + 0 practices + 14 seminars = total of 14 hours
Course headcount limitations (min.-max.): 4 – 30 Prerequisites: none
Topic
During the course we will discuss the role of iron in the metabolism. We will deal with the iron demand of microorganisms and with the
role of iron in the protective mechanisms against bacterial infections. The function of influencing factors of iron metabolism, their effects
and crosstalk between them will be discussed in detail. The roles of iron containing proteins and their functions will be talked over.
During the course we will emphasize the disorders of iron metabolism (iron deficiency, iron overload), their genetic backgrounds and
their therapies. Based on the most actual findings the role of iron in the development of neurodegenerative diseases (Parkinson’s disease,
Alzheimer’s disease and Huntington’s disease) will be also discussed.
Conditions for acceptance of the semester
Max. 3 absences
Mid-term exams
One assay and one midterm exam.
Making up for missed classes
Personal consultation
Reading material
- Obligatory literature
- Literature developed by the Department
The educational materials will be uploaded to Neptune MeetStreet
- Notes
- Recommended literature
Robert Crichton: Iron Metabolism - From Molecular Mechanisms to Clinical Consequences
Lectures
Practices
Seminars
1 Solution chemistry of iron, interactions with other metal ions.
2 The Importance of Iron for Biological Systems: haemoproteins, iron-sulfur proteins, other iron containing proteins
3 Microbial Iron Transport and Metabolism
4 Iron uptake by yeasts
5 Cellular Iron Uptake and Export in Mammals: iron transporters
6 Intracellular Iron Storage and Biomineralisation: ferritin, haemosiderin
7 Intracellular Iron Metabolism and Cellular Iron Homeostasis I: Labile iron pool, mitochondrial iron uptake and metabolism haem
biosynthesis
8 Intracellular Iron Metabolism and Cellular Iron Homeostasis II: synthesis of iron-sulfur clasters, functions of iron responsive
elements and iron regulatory proteins
9 Iron Absorption in Man: functions of luminal factors, regulation of Systemic Iron Balance
10 Pathophysiology of Iron Deficiency and Iron Overload: Acquired and Genetic Disorders of Iron Metabolism, haemochromatosis,
thalassemias, secondary iron overload, anemias
11 Iron disorders and Laboratory parameters
12 Iron and oxidative stress: cytoprotective enzymes, antioxidants, aging, role of the immune system
13 Brain iron metabolism, the role of iron in neurodegenerative diseases
14 Assay, exam
Exam topics/questions
Simple choice test based on the seminars.
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Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Nagy Tamás II (NATFABO.PTE), Dr. Pandur Edina (PAEFAA.T.JPTE), Jánosa Gergely (JAGTAAT.PTE), Pap Ramóna
(PARTAAT.PTE), Poór Viktor Soma (POVFAB.T.JPTE)
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134
OPE-EFA-T ETHNOPHARMACOBOTANY
Course director: DR. NÓRA PAPP, associate professor
Department of Pharmacognosy
2 credit ▪ midsemester grade ▪ Elective subject for the Pharmaceutical module ▪ autumn semester ▪ recommended semester: 5
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 4 – 20 Prerequisites: OPO-GN1 completed + OPO-GN2 completed
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
Several written sources are available on the ethnobotanical usage and pharmaceutical history of medicinal plants from the Ancient Times.
The course presents a summary about ethnobotanical data focusing on folk therapeutical methods and values of the Mediterranean area,
Transylvania, countries of Europe, Asia, America and Africa completed by the scientific activity and curriculum vitae of ethnobotanists
and researchers in this topic. Students receive a general approach about the rules and regularity of the special folk terminology, practice,
folk customs and symbols in consideration of medicinal plants. In addition to ethnobotanical methods, the actual state, position and
necessity of surveys are discussed during the course.
Conditions for acceptance of the semester
Satisfactory fulfilment of 2 written tests based on the lectures.
Absences: according to the Code of Studies and Examinations of the Medical School.
Mid-term exams
The required 2 tests can be retaken or corrected in the course.
Making up for missed classes
Downloading lectures.
Reading material
- Obligatory literature
- Literature developed by the Department
http://aok.pte.hu/en/egyseg/oktatasianyagok/1640
http://gytk.pte.hu/en/egyseg/oktatasianyagok/1640
- Notes
- Recommended literature
Cunninham A. B.: Applied Ethnobotany. People, Wild Plant Use and Conservation, Earthscan, London, 2002
Ellen, Davi E., Hatfield, G.: Medicinal Plants in Folk Tradition an Ethnobotany of Britain and Ireland, Timber Press, Portland,
Cambridge, 2004
Lise Manniche: The Ancient Egyptian Herbal, The British Museum Press, London, 1989
Martin G. J.: Ethnobotany. A Methods Manual, Earthscan, London, 2007
Minnis P. E.: Ethnobotany. A Reader, University of Oklahoma Press, U.S.A., 2000
Moerman, Daniel E.: Native American Ethnobotany, Timber Press, Portland, London, 2010
Paye, Gabriell DeBear: Cultural Uses of Plants, The New York Botanical Garden Press, Bronx, New York, 2000
Lectures
1 Ethnopharmacological data of the Ancient Times (Egypt, Mesopotamia).
Dr. Papp Nóra
2 Ethnopharmacological data of the Ancient Times (Egypt, Mesopotamia).
Dr. Papp Nóra
3 Ethnobotanical studies of the Native Indian populations of North, South and Central America (Cuba, Mexico).
Dr. Papp Nóra
4 Ethnobotanical studies of the Native Indian populations of North, South and Central America (Cuba, Mexico).
Dr. Papp Nóra
5 Ethnopharmacology of the ancient cultures of Iran, China, India, Tibet, Japan.
Dr. Papp Nóra
6 Ethnopharmacology of the ancient cultures of Iran, China, India, Tibet, Japan.
Dr. Papp Nóra
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7 Ethnopharmacology of African and Mediterranean countries (Greece, Spain, Portugal, Italy).
Dr. Papp Nóra
8 Ethnopharmacology of African and Mediterranean countries (Greece, Spain, Portugal, Italy).
Dr. Papp Nóra
9 Ethnopharmacological data from the Middle Ages: therapy and medicinal plants in monastery gardens.
Dr. Papp Nóra
10 Ethnopharmacological data from the Middle Ages: therapy and medicinal plants in monastery gardens.
Dr. Papp Nóra
11 Transylvanian ethnobotanical values.
Dr. Papp Nóra
12 Transylvanian ethnobotanical values.
Dr. Papp Nóra
13 Written test I.
Dr. Papp Nóra
14 Written test I.
Dr. Papp Nóra
15 Ancient medico-botanical and herbal books and written sources with the morphological and therapeutical description of medicinal
plants.
Dr. Papp Nóra
16 Ancient medico-botanical and herbal books and written sources with the morphological and therapeutical description of medicinal
plants.
Dr. Papp Nóra
17 Scientific activity and curriculum vitae of ethnobotanists.
Dr. Papp Nóra
18 Scientific activity and curriculum vitae of ethnobotanists.
Dr. Papp Nóra
19 Methodologies in ethnobotanical collection.
Dr. Papp Nóra
20 Methodologies in ethnobotanical collection.
Dr. Papp Nóra
21 Interactive lecture: analysis and elaboration of scientific articles published in international journals and books based on the
knowledge and view of the previous lectures.
Dr. Papp Nóra
22 Interactive lecture: analysis and elaboration of scientific articles published in international journals and books based on the
knowledge and view of the previous lectures.
Dr. Papp Nóra
23 Traditional and folk terminology in plant names.
Dr. Papp Nóra
24 Traditional and folk terminology in plant names.
Dr. Papp Nóra
25 Medicinal plants in folk custom and tradition as symbols.
Dr. Papp Nóra
26 Medicinal plants in folk custom and tradition as symbols.
Dr. Papp Nóra
27 Written test II.
Dr. Papp Nóra
28 Written test II.
Dr. Papp Nóra
Practices
Seminars
Exam topics/questions
According to the topics of the course.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
136
OPE-GMK-T QUALITATIVE AND QUANTITATIVE ANALYSIS OF DRUGS FROM HUMAN TISSUE
Course director: DR. ÁGNES FARKAS, associate professor
Department of Pharmacognosy
2 credit ▪ midsemester grade ▪ Elective subject for the Pharmaceutical module ▪ autumn semester ▪ recommended semester: 5
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 3 – 50 Prerequisites: none
Topic
The course provides knowledge about the traceability of active pharmaceutical ingredients in various biological matrices. It discusses
sampling of biological matrices, sample preparation (extraction) methods [LLE, SPE, SPEC, SPME, MEPS], and various
chromatographic techniques [TLC, GC, LC] as well.
The course intends to present the CNS effects of active pharmaceutical ingredients, as well as drugs in the official investigation. The
sampling procedures and techniques are presented, as well as their official confidence circumstances.
The appearance of drug compounds and drugs in biological matrices, and their pharmacokinetic properties are discussed, as well as
traceability of live and corpse biological matrices (blood, urine, hair, nails, saliva, or liver, kidney, brain, or cerebrospinal fluid).
After proper selection of analytical tests, the requirements set for a variety of measuring instruments will be discussed. Standard
evaluation and communication, as well as the laws and regulations in force in the analytical results complete the course topics.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Students have to prove their knowledge of the course material by presenting a selected topic in a short (10 min) talk. The topic should be
related to one of the topics of the course, and students should rely on their knowledge acquired in previous classes.
Making up for missed classes
According to the Code of Studies and Examinations
Reading material
- Obligatory literature
R.C. Baselt: Disposition of Toxic Drugs and Chemicals in Man, 6th ed., Biomedical Publications, Foster City, CA, 2002
A.C. Moffat, M.D. Osselton, B. Widdop: Clarke’s Analysis of Drugs and Poisons, Pharmaceutical Press, London, 2004.
- Literature developed by the Department
The Lecturer’s presentations (ppt files) will be available from the website of the Department of Pharmacognosy.
- Notes
- Recommended literature
R.J. Flanagan, A. Taylor, I.D. Watson, R. Whelpton: Fundamentals of Analytical Toxicology, John Wiley & Sons, Hoboken, NJ,
2007.
Lectures
1 Introduction to Toxicology. Categorization of Toxins I
Dr. Benkő András Antal
2 Introduction to Toxicology. Categorization of Toxins II
Dr. Benkő András Antal
3 Effect of Poisons on the Living Body I
Dr. Benkő András Antal
4 Effect of Poisons on the Living Body II
Dr. Benkő András Antal
5 Investigation in Forensic Laboratories. Sampling rules. I
Dr. Benkő András Antal
6 Investigation in Forensic Laboratories. Sampling rules. II
Dr. Benkő András Antal
7 Investigation of Non-standard Human Tissues I
Dr. Benkő András Antal
8 Investigation of Non-standard Human Tissues II
Dr. Benkő András Antal
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9 Biological Materials Preparation. Extraction Procedures I
Dr. Benkő András Antal
10 Biological Materials Preparation. Extraction Procedures II
Dr. Benkő András Antal
11 Forensic Toxicological Investigation of Human Samples by Chromatography I
Dr. Benkő András Antal
12 Forensic Toxicological Investigation of Human Samples by Chromatography II
Dr. Benkő András Antal
13 Criteria and Evaluation. Expert Opinion in Forensic Toxicology I
Dr. Benkő András Antal
14 Criteria and Evaluation. Expert Opinion in Forensic Toxicology II
Dr. Benkő András Antal
15 Natural Cannabinoids (marihuana, hashish, and hashish oil) I
Dr. Benkő András Antal
16 Natural Cannabinoids (marihuana, hashish, and hashish oil) II
Dr. Benkő András Antal
17 Synthetic Cannabino-mimetics (spice, pot-puri, herbal, bio-grass, K2) I
Dr. Benkő András Antal
18 Synthetic Cannabino-mimetics (spice, pot-puri, herbal, bio-grass, K2) II
Dr. Benkő András Antal
19 First Generation of Amphetamines (ecstasy, speed)
Dr. Benkő András Antal
20 Second generation of disco drugs (catinon and derivatives)
Dr. Benkő András Antal
21 Opiates (morphine, codeine, heroine) I
Dr. Benkő András Antal
22 Opiates (morphine, codeine, heroine) II
Dr. Benkő András Antal
23 Cocaine
Dr. Benkő András Antal
24 Body-pack Syndrome.
Dr. Benkő András Antal
25 Final Student ppt Presentation I
Dr. Benkő András Antal
26 Final Student ppt Presentation II
Dr. Benkő András Antal
27 Final Student ppt Presentation III
Dr. Benkő András Antal
28 Final Student ppt Presentation IV
Dr. Benkő András Antal
Practices
Seminars
Exam topics/questions
10 min ppt presentation based on an international forensic science article
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Benkő András Antal (BEAQAAP.PTE)
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138
OPE-KMS-T SEMINARS IN PHARMACEUTICAL SCIENCES - RESEARCH PERSPECTIVES
Course director: DR. KRISZTIÁN KVELL, associate professor
Department of Pharmaceutical Biotechnology
1 credit ▪ midsemester grade ▪ Elective subject for the Pharmaceutical module ▪ autumn semester ▪ recommended semester: 5
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 50 Prerequisites: none
Topic
Seminars in Pharmaceutical Sciences - Research Perspectives
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Written test
Making up for missed classes
None
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
www.medbiotech.com
Lectures
1 Seminars in Pharmaceutical Sciences - Research Perspectives I.
Dr. Kvell Krisztián
2 Seminars in Pharmaceutical Sciences - Research Perspectives II.
Dr. Kvell Krisztián
3 Seminars in Pharmaceutical Sciences - Research Perspectives III.
Dr. Kvell Krisztián
4 Seminars in Pharmaceutical Sciences - Research Perspectives IV.
Dr. Kvell Krisztián
5 Seminars in Pharmaceutical Sciences - Research Perspectives V.
Dr. Kvell Krisztián
6 Seminars in Pharmaceutical Sciences - Research Perspectives VI.
Dr. Kvell Krisztián
7 Seminars in Pharmaceutical Sciences - Research Perspectives VII.
Dr. Kvell Krisztián
8 Seminars in Pharmaceutical Sciences - Research Perspectives VIII.kve
Dr. Kvell Krisztián
9 Seminars in Pharmaceutical Sciences - Research Perspectives IX.
Dr. Kvell Krisztián
10 Seminars in Pharmaceutical Sciences - Research Perspectives X.
Dr. Kvell Krisztián
11 Seminars in Pharmaceutical Sciences - Research Perspectives XI.
Dr. Kvell Krisztián
12 Seminars in Pharmaceutical Sciences - Research Perspectives XII.
Dr. Kvell Krisztián
13 Seminars in Pharmaceutical Sciences - Research Perspectives XIII:
Dr. Kvell Krisztián
14 Seminars in Pharmaceutical Sciences - Research Perspectives XIV.
Dr. Kvell Krisztián
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139
Practices
Seminars
Exam topics/questions
www.medbiotech.com
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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140
OPE-TG3-T STUDENT PROJECT RESEARCH FOR STUDENTS OF PHARMACEUTIST PROGRAMME 3
Course director: DR. GYÖRGYI HORVÁTH, associate professor
Department of Pharmacognosy
2 credit ▪ midsemester grade ▪ Elective subject for the Pharmaceutical module ▪ autumn semester ▪ recommended semester: 5
Number of hours/semester: 0 lectures + 24 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPF-TG2 completed
Topic
The course aims at promoting of students to make student research projects on the field of pharmaceutical sciences. Furthermore, we
wish to give individual possibilities of students to perform experiments in the different pharmaceutical institutes involved into Students’
Research Society.
Conditions for acceptance of the semester
The continuous student’s work is recommended. The continuous enrollment of consecutive courses can be stopped and continued in
further semesters.
The prerequisite of this course (TDK 3): registration of the student in the database of Students’ Research Society and the fulfillment of
the Student Project Research for Students of Pharmaceutist Programme 2 course.
Mid-term exams
TG3
- Introduction of conference abstract or conference manuscript (student is co-author) for the course supervisor at the end of 13th week of
the semester.
- Introduction of original article published in national and/or international journals (student is co-author) at the end of 13th week of the
semester.
- Participation on Students’ Research Conference.
- Among the three conditions, one of them should be made at least.
Making up for missed classes
There is no possibility.
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
ScienceDirect database
Lectures
Practices
1-24 Research.
Seminars
Exam topics/questions
Not applicable.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Horváth Györgyi (HOGAAA.T.JPTE)
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141
ATT5-T PHYSICAL EDUCATION 5
Course director: TAMÁS TÉCZELY, physical education teacher
UP MS Sports Facilities
0 credit ▪ signature ▪ Optional subject ▪ both semesters ▪ recommended semester: 5
Number of hours/semester: 0 lectures + 28 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 2 – 50 Prerequisites: ATT4-T completed
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
This subject provides theoretical and practical information for the students to maintain and improve their physical condition and helps to
deepen the knowledge in the field of healthy lifestyle.
Theoretical and practical knowledge during different types of exercises e.g. how to improve endurance, muscle force, motor skills and
how to prevent the body from injuries.
Conditions for acceptance of the semester
Active participation at least 20 practical lessons provided by the Institute of Human Movement Sciences or regular participation of the
trainings of the Medikus Sport Club or PEAC.
Mid-term exams
-
Making up for missed classes
We provide opportunities to attend extra lessons in the first week of the exam period in that case the requirements are not fulfilled till the
end of the teaching weeks with agreement of the PE Teacher.
Reading material
- Obligatory literature
- Literature developed by the Department
Not available.
- Notes
- Recommended literature
Lectures
Practices
1-28 For the list of actual courses please turn to the end of the Basic Module document
Seminars
Exam topics/questions
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Farkas György (FAGMAAO.PTE), Lipcsik Zoltán (LIZIAAT.PTE), Németh Attila Miklós (NEAGAET.PTE), Téczely Tamás
(PETLAAT.PTE)
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142
OPF-EGZ-T EGZOTIC MEDICINAL PLANTS
Course director: DR. GYÖRGYI HORVÁTH, associate professor
Department of Pharmacognosy
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPA-GN2 completed
Topic
The course includes 28 lectures. The aim of the course is to present the most frequently used exotic plants in the medical therapy. The
course gives a general overview about the botanical character, active ingredients, and drug part of the plants. Application forms and
safety instructions are also highlighted during the lectures. Herbs and drugs will presented according to their areas of application.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Oral presentation about a medicinal value of a selected plant. Fulfillment of the final test (minimum 60%).
Making up for missed classes
Downloading of lectures in Neptun.
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
Bremness L. (1988): The Complete Book of Herbs: A Practical Guide to Growing and Using Herbs.
Ratsch C., Hofmann A.(2007): The Encyclopedia of Psychoactive Plants: Ethnopharmacology and Its Applications.
Kane C.W. (2007): Medicinal Plants of the Western Mountain States
Bett J. (2015): Chinese Medicinal Plants: How To Grow Them, How To Use Them: Growing and Using Herbs And Plants For
Natural Remedies And Healing.
Lectures
1 Herbs of the gastrointestinal tract I.
Dr. Ács Kamilla
2 Herbs of the gastrointestinal tract II.
Dr. Ács Kamilla
3 Herbs of the gastrointestinal tract III.
Dr. Ács Kamilla
4 Herbs of the gastrointestinal tract IV.
Dr. Ács Kamilla
5 Aromatic plants and products containing essential oils I.
Dr. Ács Kamilla
6 Aromatic plants and products containing essential oils II.
Dr. Ács Kamilla
7 Aromatic plants and products containing essential oils III.
Dr. Ács Kamilla
8 Aromatic plants and products containing essential oils IV.
Dr. Ács Kamilla
9 Herbs and products containing fatty oils I.
Dr. Ács Kamilla
10 Herbs and products containing fatty oils II.
Dr. Ács Kamilla
11 Plants for external use, dermatology and cosmetics I.
Dr. Ács Kamilla
12 Plants for external use, dermatology and cosmetics II.
Dr. Ács Kamilla
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13 Plants which affect the central nervous system I.
Dr. Ács Kamilla
14 Plants which affect the central nervous system II.
Dr. Ács Kamilla
15 Plants for cardiovascular disorders I.
Dr. Ács Kamilla
16 Plants for cardiovascular disorders II.
Dr. Ács Kamilla
17 Plants for well-being I.
Dr. Ács Kamilla
18 Plants for well-being II.
Dr. Ács Kamilla
19 Psychoactive and hallucinogenic plants I.
Dr. Ács Kamilla
20 Psychoactive and hallucinogenic plants II.
Dr. Ács Kamilla
21 Plants with immunostimulant effect I.
Dr. Ács Kamilla
22 Plants with immunostimulant effect II.
Dr. Ács Kamilla
23 Plants for tropical, and contagious diseases I.
Dr. Ács Kamilla
24 Plants for tropical, and contagious diseases II.
Dr. Ács Kamilla
25 Presentations of students I.
Dr. Ács Kamilla
26 Presentations of students II.
Dr. Ács Kamilla
27 Exam
Dr. Ács Kamilla
28 Exam
Dr. Ács Kamilla
Practices
Seminars
Exam topics/questions
It is similar to the topics of lectures.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPF-GKG-T GAS CHROMATOGRAPHY
Course director: DR. VIKTÓRIA POÓR, assistant professor
Institute of Bioanalysis
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5
Number of hours/semester: 7 lectures + 7 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 4 – 10 Prerequisites: OPA-MAN completed
Topic
Key
Topics
-practical theory about Gas Chromatography
-how to select and use the carrier gas
-various injection techniques and when to use each
-how to select a GC column
-the operation and selection of an appropriate GC detector
-how to write measuring methods
-how to undertake data analysis
-sampling techniques for GC
-strategies for method development
-introduction to GC & MS advanced techniques
-applications (pharmaceutical application)
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
1 test during the semester
1 oral presentation (based on research articles on the field of pharmaceutical apllication)
Making up for missed classes
There is no possibility for retake
Reading material
- Obligatory literature
Modern Analytical Cheymistry,David Harvey
- Literature developed by the Department
www.aok.pte.hu/bioanalitika
- Notes
- Recommended literature
Lectures
1 Introduction
Dr. Poór Viktória
2 Parts of gas chromatograph
Gases, injection techniques
Dr. Poór Viktória
3 Columns
Dr. Poór Viktória
4 Detectors
Dr. Poór Viktória
5 Gas chromatography-mass spectrometry
Dr. Poór Viktória
6 Data analysis
Dr. Poór Viktória
7 Applications, pharmaceutical applications
Dr. Poór Viktória
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Practices
1 Introduction
2 How to write a measuring methods
3 How to write a measuring methods
4 Measurements with flame ionization detector
5 Measurements with mass spectrometer detector
6 Data analysis
7 Sample preperation techiques
Seminars
Exam topics/questions
1 test during the semester
1 oral presentation (based on research articles on the field of pharmaceutical apllication)
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Poór Viktória (POVAAA.T.JPTE)
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146
OPF-GLK-T BIOINORGANIC CHEMISTRY FOR PHARMACY STUDENTS
Course director: DR. IMRE HUBER, associate professor
Department of Pharmaceutical Chemistry
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 15
Prerequisites: OPA-AS2 completed + OPA-SK2 completed + OPA-BA2 completed
Topic
We will provide an overview in this block about bioinorganic topics of chemistry, regarding the role of the different elements in medicinal
and pharmaceutical chemistry. Our aim is to offer a concise knowledge also about bioinorganic relations on medical contrast agents like
X-ray, tomographic, MR and ultrasound contrast agents. The use of radionuclids in diagnostical methods will be discussed too.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
Students will have to write a written test at the end of the semester.
Making up for missed classes
In case of absences the students must follow up with self-education!
Reading material
- Obligatory literature
- Literature developed by the Department
Lecture notes provided by the lecturer.
- Notes
- Recommended literature
Lectures
1 Introduction, The biological importance of non-metals and metals.
Dr. Huber Imre
2 An overview of the elements.
Dr. Huber Imre
3 Rtg-contrast agents.
Dr. Huber Imre
4 Watersoluble nephrothrop Rtg-contrast agents with high osmolality.
Dr. Huber Imre
5 Watersoluble nephrothrop Rtg-contrast agents with low osmolality.
Dr. Huber Imre
6 Watersoluble hepatothrop Rtg-contrast agents.
Dr. Huber Imre
7 Water-insoluble Rtg-contrast agents.
Dr. Huber Imre
8 Contrast agents for MRI.
Dr. Huber Imre
9 Contrast agents for CT.
Dr. Huber Imre
10 Contrast agents for ultrasound.
Dr. Huber Imre
11 Radioactive diagnostics (radionuclids).
Dr. Huber Imre
12 Platinum comlexes in medicin. Chelation therapy.
Dr. Huber Imre
13 Bisphosphonates in medicin.
Dr. Huber Imre
14 Geometry of complexes. Closing written test.
Dr. Huber Imre
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Practices
Seminars
Exam topics/questions
These are listed in the lecture notebook written by the lecturer. These notes are about the different questions of this field with the
corresponding answers, parallely.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPF-GMT-T DRUG METABOLISM AND DRUG TOXICITY
Course director: DR. ATTILA ALMÁSI, assistant professor
Department of Pharmaceutical Chemistry
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 3 – 50 Prerequisites: OPA-G1B completed
Topic
On the seminaries of this facultative course the molecular background and the influenceability of the side and toxic effects of different
drugs are aimed, during the drug absorption, drug transformation and drug elimination.
During the course, the metabolic activation and transformation of the environmental carcinogens are to be discussed.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
In the end of the semester the students write an end-semester test. The test is evaluated in percentage and the final grade is to be established
based on this result. The result of the test should be above 60%.
Making up for missed classes
The replacement of the missed test is required.
Reading material
- Obligatory literature
- Literature developed by the Department
Slides of the lectures.
- Notes
- Recommended literature
Lectures
1 Introduction. The toxicological aspects of drug metabolism.
Dr. Almási Attila
2 Characteristics of xenobiotics in the body
Dr. Almási Attila
3 Metabolic transformation I. Phase I. or functionalisation reactions 1 (CYP enzymes).
Dr. Almási Attila
4 Metabolic transformations II. Phase I. or functionalisation reactions 2 (FAD enzymes and non microsomal transformations).
Dr. Almási Attila
5 Metabolic transformations III. Phase II. or conjugation reactions 1 ( glucuronic acid conjugation, sulphate conjugation).
Dr. Almási Attila
6 Metabolic transformations IV. Phase II. or conjugation reactions 2 ( amino acid conjugation, acetylation, methylation, gluthatione
conjugation).
Dr. Almási Attila
7 Phase III. transformations (transporters), general molecular mechanism of drug toxicity.
Dr. Almási Attila
8 Biotransformation and the toxic effects of the paracetamol. Factors influence the toxicity of the paracetamol.
Dr. Almási Attila
9 Toxicity of the non-steroid antiinflammatory drugs (NSAIDs). Hepatotoxic effect of the diclofenac.
Dr. Almási Attila
10 Toxicity of the troglitazone. Sulfonamide hypersensitivity.
Dr. Almási Attila
11 Chemical carcinogenesis I., Definition, cell division, environmental carcinogens, chemical carcinogenesis.
Dr. Almási Attila
12 Chemical carcinogenesis II., Structure and metabolic activation of environmental carcinogens.
Dr. Almási Attila
13 Metabolic differences between species, genetic polymorphism.
Dr. Almási Attila
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14 Changes in drug metabolism during pregnancy and at aged people.
Dr. Almási Attila
Practices
Seminars
Exam topics/questions
Based on the announced thesis list.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPF-HVS-T SYNTHESIS OF HETEROCYCLIC COMPOUNDS AND THEIR APPLICATION IN THERAPY
Course director: DR. TAMÁS KÁLAI, professor
Department of Pharmaceutical Chemistry
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5
Number of hours/semester: 0 lectures + 0 practices + 28 seminars = total of 28 hours
Course headcount limitations (min.-max.): 1 – 12 Prerequisites: OPA-SV1 completed
Topic
Heterocyclic chemistry is an important subdivision of organic chemistry, as 70% of all medicines are heterocyclic compound or contains
a heterocyclic moiety. This course will give an introduction to, and the summary of, the most important principles and ideas of
heterocyclic chemistry. This course partially re-calls the knowledge of Organic chemisty 1 and Organic chemistry 2 course, discusses
those details which were not reflected on, because of time shortage and supports to evaluate the pharmacological chemistry subject.
Electronic structure of heterocycles
-Nomenclature of heterocyclic compounds
-Main synthetic routes to heterocyclic compounds
-Saturated heterocycles
-Three and four membered heterocycles (synthesis, reactions, occurence)
-The pyrrole and indole (synthesis, reactions, occurence)
-Furan, thiophene and their benzo derivatives.
-Five membered heterocycles with two or more heteroatoms
-Six-membered heterocycles with one oxygen heteroatom (piranes, chromones, flavones and coumarins)
-Six membered heterocycles with one nitrogen atom (pyridine, quinoline, isoquinoline)
-Six membered heterocycles with two or more heteroatoms (purine, diazines etc.)
-Seven membered heterocyclic chemistry
- Heterocycles in supramolecular chemitry
-Heterocyclic compounds in organic snthesis
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
The students write two tests, at the middle of the semester and at the end of the semester. Every student have a chance to make a
presentation based on a heterocyclic chemistry paper for an extra grade.
Making up for missed classes
Personal communication. The english program student might visit the paralell hungarian course to catch up the main reaction equations.
Reading material
- Obligatory literature
Li, J. J. Hetrocyclic chemistry in Drug Discovery, Wiley
- Literature developed by the Department
Slides will be given to students as a ppt or pdf files.
- Notes
Joule, J. J.; Mills, K. Heterocyclic chemistry at a Glance. (Wiley)
- Recommended literature
Li, J. J. Top 10 drugs Oxfors University Press
Lectures
Practices
Seminars
1 Electronic structure of heterocycles
2 Nomenclature of heterocyclic compounds
3 Heterocycles in natural products
4 Common reaction types in heterocyclic chemistry
5 The main syntetic methods of heterocycles
6 Palladium in heterocyclic chemistry
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7 Three and four membered heterocycles, beta lactams
8 Three and four-membered heterocycles and beta lactams
9 Synthesis of pyrroles and porfirine ring containing compounds
10 Synthesis of indoles, main reactions of indoles.
11 Furans and benzofurans
12 Thiophenes and benzothiophenes
13 1,2-azoles, their synthesis, reactions and their occurence in drugs
14 1,3-azoles, their synthesis, reactions, occurence in drugs
15 1st test (generral feature of heterocyclic compounds (3-, 4-, 5-membered heterocycles)
16 Six membered heterocycles containing oxygen heteroatom
17 Pyridines (synthesis, reactions, occurence in drugs and biomolecules)
18 Quinolines, isoquinolines (synthesis, reactions, occurence in drugs)
19 Synthesis of pyrimidines and their occurence in medicines
20 Synthesis and reactions of 1,2- and 1,4-diazines
21 Quinoxalines, quinazolines and quinazolinones
22 Synthesis and reaction of purines
23 Nucleic acid based drugs
24 Seven-membered heterocyclic compounds, their role in medicines
25 Heterocycles in supramolecular chemistry
26 Heterocycles in organic synthesis
27 2nd test (6- and 7-membered heterocycles)
28 Short presentations, evaluations
Exam topics/questions
-Electronic structure of heterocycles
-Nomenclature of heterocyclic compounds
-Main synthetic routes to heterocyclic compounds
-Saturated heterocycles
-Three and four membered heterocycles (synthesis, reactions, occurence)
-The pyrrole and indole (synthesis, reactions, occurence)
-Furan, thiophene and their benzo derivatives.
-Five membered heterocycles with two or more heteroatoms
-Six-membered heterocycles with one oxygen heteroatom (piranes, chromones, flavones and coumarins)
-Six membered heterocycles with one nitrogen atom (pyridine, quinoline, isoquinoline)
-Six membered heterocycles with two or more heteroatoms (purine, diazines etc.)
-Seven membered heterocyclic chemistry
- Heterocycles in supramolecular chemitry
-Heterocyclic compounds in organic snthesis
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Kálai Tamás (KATFABP.PTE)
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OPF-MME-T MOLECULAR MEDICINE
Course director: DR. JUDIT PONGRÁCZ, professor
Department of Pharmaceutical Biotechnology
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 150 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
Introduction into molecular medicine
Conditions for acceptance of the semester
According to the Code of Studies and Examinations
Mid-term exams
Writing test
Making up for missed classes
None
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
www.medbiotech.com
- Recommended literature
Lectures
1 Introduction into molecular medicine
Dr. Pongrácz Judit
2 The genome
Dr. Pongrácz Judit
3 Sequencing of the genome
Dr. Pongrácz Judit
4 Investigation of the human genome with microarrays
Dr. Pongrácz Judit
5 Genes and diseases
Dr. Pongrácz Judit
6 Nuclear receptors
Dr. Pongrácz Judit
7 Personalized genetics
Dr. Pongrácz Judit
8 Immunodeficiencies
Dr. Pongrácz Judit
9 Cancers (introduction)
Dr. Pongrácz Judit
10 Molecular mechanisms of cancer development
Dr. Pongrácz Judit
11 Obesity: introduction
Dr. Pongrácz Judit
12 Genomics of obesity
Dr. Pongrácz Judit
13 Genes involved in development of obesity
Dr. Pongrácz Judit
14 Therapeutic approaches to obesity. Interconnected mechanisms in lipid metabolism
Dr. Pongrácz Judit
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Practices
Seminars
Exam topics/questions
www.medbiotech.com
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPF-MOD-T MOLECULAR DIAGNOSTICS
Course director: DR. JUDIT PONGRÁCZ, professor
Department of Pharmaceutical Biotechnology
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 150 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
Structure of a molecular genetic laboratory, working areas, special devices and instrumentation. Biological information.
Conditions for acceptance of the semester
According to the Code of Studies and Examinations
Mid-term exams
Writing test
Making up for missed classes
According to the Code of Studies and Examinations
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
www.medbiotech.com
- Recommended literature
Lectures
1 Structure of a molecular genetic laboratory, working areas, special devices and instrumentation. Biological information.
Dr. Pongrácz Judit
2 Mutations, polymorphisms. The genetic code.
Dr. Pongrácz Judit
3 Mutations, polymorphisms. The genetic code.
Dr. Pongrácz Judit
4 Special mutation consequences.
Dr. Pongrácz Judit
5 Dynamic mutations.
Dr. Pongrácz Judit
6 Mendelian inheritance.
Dr. Pongrácz Judit
7 Multifactorial diseases.
Dr. Pongrácz Judit
8 Examples for monogenic diseases.
Dr. Pongrácz Judit
9 Examples for monogenic diseases.
Dr. Pongrácz Judit
10 Examples for monogenic diseases.
Dr. Pongrácz Judit
11 Pharmacogenetics.
Dr. Pongrácz Judit
12 Molecular testing in oncology.
Dr. Pongrácz Judit
13 Methodology of the molecular diagnostic procedures.
Dr. Pongrácz Judit
14 Methodology of the molecular diagnostic procedures.
Dr. Pongrácz Judit
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Practices
Seminars
Exam topics/questions
www.medbiotech.com
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPF-MOT-T MOLECULAR THERAPIES
Course director: DR. JUDIT PONGRÁCZ, professor
Department of Pharmaceutical Biotechnology
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 150 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
Gene therapy, in vivo gene therapy
Conditions for acceptance of the semester
According to the Code of Studies and Examinations
Mid-term exams
Writing test
Making up for missed classes
None
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
www.medbiotech.com
- Recommended literature
Lectures
1 Functional genomics I
Dr. Pongrácz Judit
2 Functional genomics II
Dr. Pongrácz Judit
3 Recombinant protein expression
Dr. Pongrácz Judit
4 Gene therapy, in vivo gene therapy
Dr. Pongrácz Judit
5 Ex vivo gene therapy, Therapies based on protein replacement I
Dr. Pongrácz Judit
6 Therapies based on protein replacement II
Dr. Pongrácz Judit
7 Recombinant antibodies and phage phage display technique
Dr. Pongrácz Judit
8 Anti-cytokine therapy (Sepsis)
Dr. Pongrácz Judit
9 Transgene technology and mouse models in modern biological research
Dr. Pongrácz Judit
10 Embryonic and adult stem cells for regenerative medicine I
Dr. Pongrácz Judit
11 Embryonic and adult stem cells for regenerative medicine II
Dr. Pongrácz Judit
12 Cell cycle and cancer therapy, p53 I
Dr. Pongrácz Judit
13 Cell cycle and cancer therapy, p53 II
Dr. Pongrácz Judit
14 Gene silencing technologies
Dr. Pongrácz Judit
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Practices
Seminars
Exam topics/questions
www.medbiotech.com
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
158
OPE-ASZ-T THE ANTIMICROBIAL DRUGS AND THEIR CLINICAL USE
Course director: DR. BÉLA KOCSIS, associate professor
Department of Medical Microbiology and Immunology
2 credit ▪ midsemester grade ▪ Elective subject for the Medical/Biological module ▪ spring semester ▪ recommended semester: 6
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 100 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The aim of these lectures is to give a reliable and detailed knowledge about the antimicrobial drugs and their clinical use; to give ideas
how to choose the proper drug for the prophylaxis and therapy of infectious diseases
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
In the first 2 weeks of the exam period we give three times possibilities to write tests
Making up for missed classes
None
Reading material
- Obligatory literature
Jawetz et al.: Medical Microbiology
- Literature developed by the Department
- Notes
- Recommended literature
Lectures
1 Introduction, historical data, basic definitions
Dr. Kocsis Béla
2 Characterisation of antimicrobial drugs, chemical structure, their targets
Dr. Kocsis Béla
3 Characterisation of antimicrobial drugs, sensitivity and resistance
Dr. Kocsis Béla
4 Characterisation of antimicrobial drugs, sensitivity and resistance
Dr. Kocsis Béla
5 Pharmacokinetics and pharmacodynamics of anti-infective drugs
Dr. Kocsis Béla
6 The antibiotic prophylaxis.
Dr. Kocsis Béla
7 The empiric antimicrobial therapy
Dr. Kocsis Béla
8 The antimicrobial therapy based on microbiologic result
Dr. Kocsis Béla
9 The choice of best antimicrobial drug
Dr. Kocsis Béla
10 The reasons of an unsuccessful antimicrobial therapy
Dr. Kocsis Béla
11 The antimicrobial drugs in details. The inhibitors of the cell wall biosynthesis Beta-lactams Penicillins
Dr. Kocsis Béla
12 Cephalosporins
Dr. Kocsis Béla
13 Carbapenems, monobactams, glicopeptides
Dr. Kocsis Béla
14 The inhibitors of the protein biosynthesis Aminoglicosides
Dr. Kocsis Béla
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15 Tetracyclines Chloramphenicol Macrolides
Dr. Kocsis Béla
16 The inhibitors of the nucleic acid biosynthesis Rifampins Sulfonamides
Dr. Kocsis Béla
17 Kinolons Fluorokinolons
Dr. Kocsis Béla
18 The antimycotic drugs
Dr. Kocsis Béla
19 The antimycotic drugs
Dr. Kocsis Béla
20 The antiviral drugs
Dr. Kocsis Béla
21 The antiviral drugs HIV - AIDS
Dr. Kocsis Béla
22 The antiparasitic therapy. The chemoprophylaxis of malaria
Dr. Kocsis Béla
23 The antimicrobial therapy of respiratory and urinary tract infections
Dr. Kocsis Béla
24 Cardiovascular and wound infections, sepsis
Dr. Kocsis Béla
25 Central nervous system, abdominal and enteric infections
Dr. Kocsis Béla
26 Antimicrobial therapy of patients under immunosuppression, pregnancy....
Dr. Kocsis Béla
27 The pharmacological aspects of antimicrobial therapy
Dr. Kocsis Béla
28 The future of antimicrobial therapy
Dr. Kocsis Béla
Practices
Seminars
Exam topics/questions
None
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
160
OPE-GFK-T PHYSICO-CHEMICAL BASES OF DRUG ACTION
Course director: DR. PÁL PERJÉSI, professor
Department of Pharmaceutical Chemistry
2 credit ▪ midsemester grade ▪ Elective subject for the Pharmaceutical module ▪ autumn semester ▪ recommended semester: 6
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 2 – 15 Prerequisites: none
Topic
The main objective of this course is to expand the knowledge in phyisico-chemical characterization of drug molecules and drug targets
for better understanding the drug action.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
Written exam
Making up for missed classes
None
Reading material
- Obligatory literature
- Literature developed by the Department
Lecture notes
- Notes
- Recommended literature
Vogel HG: Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays, Springer, 2006
Lectures
1 Molecular bases of biological actions. Structural characteristics of drug targets.
Dr. Rozmer Zsuzsanna
2 Molecular bases of biological actions. Structural characteristics of drug targets.
Dr. Rozmer Zsuzsanna
3 Receptors as drug targets.
Dr. Rozmer Zsuzsanna
4 Receptors as drug targets.
Dr. Rozmer Zsuzsanna
5 Enzymes as drug targets.
Dr. Rozmer Zsuzsanna
6 Enzymes as drug targets.
Dr. Rozmer Zsuzsanna
7 Transporters and ion channels as drug targets.
Dr. Rozmer Zsuzsanna
8 Transporters and ion channels as drug targets.
Dr. Rozmer Zsuzsanna
9 Nucleic acids as drug targets.
Dr. Rozmer Zsuzsanna
10 Nucleic acids as drug targets.
Dr. Rozmer Zsuzsanna
11 Physicochemical properties of drug-drug target interactions. Intermolecular bonding.
Dr. Rozmer Zsuzsanna
12 Physicochemical properties of drug-drug target interactions. Intermolecular bonding.
Dr. Rozmer Zsuzsanna
13 Physicochemical properties of drug-drug target interactions. Affinity. Efficiency and selectivity.
Dr. Rozmer Zsuzsanna
14 Physicochemical properties of drug-drug target interactions. Affinity. Efficiency and selectivity.
Dr. Rozmer Zsuzsanna
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15 Physicochemical properties of drug-drug target interactions. Stucture, stereochemistry.
Dr. Rozmer Zsuzsanna
16 Physicochemical properties of drug-drug target interactions. Stucture, stereochemistry.
Dr. Rozmer Zsuzsanna
17 Physicochemical characteristics of drugs. Solubility.
Dr. Rozmer Zsuzsanna
18 Physicochemical characteristics of drugs. Solubility.
Dr. Rozmer Zsuzsanna
19 Physicochemical characteristics of drugs. Acid-base properties. Relevance and determination of the pKa value.
Dr. Rozmer Zsuzsanna
20 Physicochemical characteristics of drugs. Acid-base properties. Relevance and determination of the pKa value.
Dr. Rozmer Zsuzsanna
21 Physicochemical characteristics of drugs. Lipophilicity and partition coefficient. Determination of partition coefficients.
Dr. Rozmer Zsuzsanna
22 Physicochemical characteristics of drugs. Lipophilicity and partition coefficient. Determination of partition coefficients.
Dr. Rozmer Zsuzsanna
23 Physicochemical characteristics of drugs. Permeability. Experimental methods to determine permeability.
Dr. Rozmer Zsuzsanna
24 Physicochemical characteristics of drugs. Permeability. Experimental methods to determine permeability.
Dr. Rozmer Zsuzsanna
25 In silico ADME modelling. In vitro and in vivo tests.
Dr. Rozmer Zsuzsanna
26 In silico ADME modelling. In vitro and in vivo tests.
Dr. Rozmer Zsuzsanna
27 Physicochemical characteristics of drugs. Metabolic stability.
Dr. Rozmer Zsuzsanna
28 Physicochemical characteristics of drugs. Metabolic stability.
Dr. Rozmer Zsuzsanna
Practices
Seminars
Exam topics/questions
Written test, questions avalaible from the teacher
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPE-KPR-T CHEMOPREVENTION
Course director: DR. TÍMEA VARJAS, assistant professor
Department of Public Health Medicine
1 credit ▪ midsemester grade ▪ Elective subject for the Medical/Biological module ▪ spring semester ▪ recommended semester: 6
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 1 – 30 Prerequisites: OPO-MB2 completed
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
Chemoprevention is the administration of natural or (semi)synthetic agents to prevent, inhibit, or delay the progression of chronic
diseases. The focus is on cancer chemoprevention.
The way from a potent agent to a chemopreventive strategy will also be discussed.
Involving (chemo)preventive interventions in every-day practice could spare valuable life years.
Conditions for acceptance of the semester
Absences should not exceed 15% of lectures and practicals (2x45 min). Otherwise signature of grade book is denied.
Examination: test
Mid-term exams
Examination: test
Making up for missed classes
based on individual consideration
Reading material
- Obligatory literature
- Literature developed by the Department
PPT-presentations (Neptun)
- Notes
- Recommended literature
Lectures
1 Introduction; Chemoprevention as a preventive strategy
Dr. Szabó István
2 Introduction; Chemoprevention as a preventive strategy
Dr. Szabó István
3 Finding evidence
Dr. Szabó István
4 Finding evidence
Dr. Szabó István
5 Interventing chronic diseases I
Dr. Szabó István
6 Interventing chronic diseases I
Dr. Szabó István
7 Interventing chronic diseases II
Dr. Szabó István
8 Interventing chronic diseases II
Dr. Szabó István
9 Chemopreventive strategies - antioxidants
Dr. Szabó István
10 Actualities of antioxidants
Dr. Szabó István
11 Natural chemopreventive agents
Dr. Szabó István
12 Natural chemopreventive agents
Dr. Szabó István
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13 Chemopreventive dietary factors
Dr. Szabó István
14 Chemopreventive dietary factors
Dr. Szabó István
Practices
Seminars
Exam topics/questions
Neptun
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPE-STK-T BASICS OF STEREOCHEMISTRY
Course director: DR. IMRE HUBER, associate professor
Department of Pharmaceutical Chemistry
1 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ spring semester ▪ recommended semester: 6
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 15
Prerequisites: OPA-SK2 completed + OPG-GK1 completed + OPA-BA2 completed
Topic
In the frame of this topic we will provide an overview about fundamentals of stereochemical definitions and processes. The students will
receive the most important knowledge about stereochemistry, with what they can understand the different binding types of drugs to their
place of biological action.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
Students will have to write a written test at the end of the semester.
Making up for missed classes
In case of absences the students must follow up with self-education!
Reading material
- Obligatory literature
- Literature developed by the Department
Lecture notes provided by the lecturer.
- Notes
Lecture notes provided by the lecturer.
- Recommended literature
K.-H. Hellwich, C. D. Siebert: Stereochemistry workbook, 191 problems and solutions, Springer, 2006.
Lectures
1 Introduction, confoguration, conformation definitions.
Dr. Huber Imre
2 Chirality, asymmetry.
Dr. Huber Imre
3 Asymmetric syntheses
Dr. Huber Imre
4 Fischer projection, CIP system.
Dr. Huber Imre
5 Diastereomers, enantiomers.
Dr. Huber Imre
6 Epimers, eutomers, distomers.
Dr. Huber Imre
7 Homochirality, inversion, meso-isomers.
Dr. Huber Imre
8 Newman projection.
Dr. Huber Imre
9 Optical purity.
Dr. Huber Imre
10 Prochirality, prostereoisomerism.
Dr. Huber Imre
11 Racemate, racemisation.
Dr. Huber Imre
12 Retention in stereochemistry.
Dr. Huber Imre
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13 Stereoselectivity, stereospecificity.
Dr. Huber Imre
14 Summary, written test.
Dr. Huber Imre
Practices
Seminars
Exam topics/questions
These are listed in the lecture notebook written by the lecturer. These notes are about the different questions of this field with the
corresponding answers, parallely.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPE-TG4-T STUDENT PROJECT RESEARCH FOR STUDENTS OF PHARMACEUTIST PROGRAMME 4
Course director: DR. GYÖRGYI HORVÁTH, associate professor
Department of Pharmacognosy
2 credit ▪ midsemester grade ▪ Elective subject for the Pharmaceutical module ▪ spring semester ▪ recommended semester: 6
Number of hours/semester: 0 lectures + 24 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPE-TG3 completed
Topic
The course aims at promoting of students to make student research projects on the field of pharmaceutical sciences. Furthermore, we
wish to give individual possibilities of students to perform experiments in the different pharmaceutical institutes involved into Students’
Research Society.
Conditions for acceptance of the semester
The continuous student’s work is recommended. The continuous enrollment of consecutive courses can be stopped and continued in
further semesters.
The prerequisite of this course (TDK 4): registration of the student in the database of Students’ Research Society and the fulfillment of
the Student Project Research for Students of Pharmaceutist Programme 3 course.
Mid-term exams
TG4
- Introduction of conference abstract or conference manuscript (student is co-author) for the course supervisor at the end of 13th week of
the semester.
- Introduction of an article published in a national and/or international journal (student is co-author). It must be sent to the course
supervisor at the end of 13th week of the semester.
- Oral presentation at the Students’ Research Conference.
- Dean’s thesis
- Among the four conditions, one of them should be made at least.
Making up for missed classes
There is no possibility.
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
ScienceDirect database
Lectures
Practices
1-24 Research.
Seminars
Exam topics/questions
Not applicable.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Horváth Györgyi (HOGAAA.T.JPTE)
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OPE-VFM-T BUSINESS DEVELOPMENT AND MANAGEMENT (KÜLÖN KURZUS!!!)
Course director: DR. BOGNÁR RITA, ügyvivő szakértő
Department of Biochemistry and Medical Chemistry
2 credit ▪ midsemester grade ▪ Elective subject for the Pharmaceutical module ▪ spring semester ▪ recommended semester: 6
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 1 – 30 Prerequisites: none
Topic
The main objective of the course is to develop the business orientation skills of the students, while deepening their knowledge in business
models, business plans, innovative business strategies, time-, product-, process- and human resource management. Participants will have
the capability how to develop healthcare businesses in international environment and how to plan better their time.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
TVSZ szerint
Making up for missed classes
Következő félévben, TVSZ szerint.
Reading material
- Obligatory literature
- Literature developed by the Department
Neptun
- Notes
- Recommended literature
1. Baum Neil, Thomas Raju : The Basics of Business of Medicine, 2015
2. Helen Ewing: Healthcare Finance: An Introduction to Accounting and Financial Management, 5th edition, 2013
Lectures
1 Global healthcare
Dr. Bognár Rita
2 Different healthcare systems
Dr. Bognár Rita
3 Regional healthcare
Dr. Bognár Rita
4 Different types of business organisations
Dr. Bognár Rita
5 Innovation, Innovative businesses
Dr. Bognár Rita
6 Business Model Generation
Dr. Bognár Rita
7 Business plan
Dr. Bognár Rita
8 Business plan development
Dr. Bognár Rita
9 Intercultural business communication
Dr. Bognár Rita
10 Basics of Marketing in healthcare business
Dr. Bognár Rita
11 Production
Dr. Bognár Rita
12 Product and process management
Dr. Bognár Rita
13 Quality management
Dr. Bognár Rita
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14 Time planning
Dr. Bognár Rita
15 Time management
Dr. Bognár Rita
16 Human resource management
Dr. Bognár Rita
17 Team building
Dr. Bognár Rita
18 Team work
Dr. Bognár Rita
19 Strategic management
Dr. Bognár Rita
20 Risk management
Dr. Bognár Rita
21 Healthcare finance
Dr. Bognár Rita
22 Introduction to accounting and financial management
Dr. Bognár Rita
23 Sustainable healthcare
Dr. Bognár Rita
24 Presenation methods
Dr. Bognár Rita
25 Presentation techniques
Dr. Bognár Rita
26 Administration
Dr. Bognár Rita
27 Documentation, Reports
Dr. Bognár Rita
28 Summary for written test
Dr. Bognár Rita
Practices
Seminars
Exam topics/questions
Neptun
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPF-DTS-T THE ROLE OF DRUG TRANSPORTERS
Course director: DR. LUCA JÁROMI, assistant professor
Department of Pharmaceutical Biotechnology
2 credit ▪ midsemester grade ▪ Optional subject ▪ both semesters ▪ recommended semester: 6
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 15 Prerequisites: OPG-GK1-T completed
Topic
Understanding the clinical importance, role and molecular procedures of interindividual variability in drug response is a critical area of
drug development and clinical pharmacotherapy.The genetic polymorphisms in drug-metabolizing enzymes, receptors, transporters and
other drug targets may have a crucial role in the background of this phenomenon, that can lead to the interindividual differences in
molecular ways, efficacy, as well as toxicity as a response to numerous clinical treatment. Cancer is the leading cause of mortality and
morbidity worldwide. The greatest obstacle of the successful treatment is the development of multidrug resistance (MDR) against
chemotherapy. During the past two decades, the act of carrier-mediated transport in defining the pharamcokinetics of drugs has become
progressively evident with the discovery of genetic polymorphisms that influence expression, localization, and/or function of a given
drug transporter. The aim of the course is to present the drug transporters and their genetic and pharmacogenetic background, to explain
their role in drug metabolism, especially focusing on different drug transporter families and on interactions of protein - drug - transporters.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Félév végén vizsga, vizsgaidőszakban pótvizsga lehetőségek
Making up for missed classes
Nincs, mert csak előadásokból áll a kurzus.
Reading material
- Obligatory literature
- Literature developed by the Department
PPT-bemutatók az előadások során.
- Notes
- Recommended literature
1.) Yuichi Sugiyama - Bente Steffansen
Transporters in Drug Development Discovery, Optimization,
Clinical Study and Regulation
ISSN 2210-7371 ISSN 2210-738X (electronic)
ISBN 978-1-4614-8228-4 ISBN 978-1-4614-8229-1 (eBook)
DOI 10.1007/978-1-4614-8229-1
Springer New York Heidelberg Dordrecht London
Library of Congress Control Number: 2013947789
2.) Toshihisa Ishikawa, Richard B. Kim
Pharmacogenomics of Human Drug Transporters
ISBN 978-0-470-92794-6
3.) Russ. B. Altman, David Flockhart, David B. Goldstein
Pharmacogenetics and Pharmacogenomics
ISBN 978-0-521-88537-9
Lectures
1 Introduction to world of drug transporters
Dr. Járomi Luca
2 General characteristics of drug transporters
Dr. Járomi Luca
3 Terms definition of drug transporters
Dr. Járomi Luca
4 Genetic role of drug transporters
Dr. Járomi Luca
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5 Pharmacogenetic characteristics of drug transporters
Dr. Járomi Luca
6 Basics in phamacokinetics: definition of absorption, distribution, metabolism, and excretion (ADME)
Dr. Járomi Luca
7 Explanation of absorption, distribution, metabolism, and excretion (ADME)
Dr. Járomi Luca
8 Membrane transporters in ADME I.
Dr. Járomi Luca
9 Membrane transporters in ADME II.
Dr. Járomi Luca
10 ADME pharmacogenomics in drug development I.
Dr. Járomi Luca
11 ADME pharmacogenomics in drug development II.
Dr. Járomi Luca
12 The role of transporters in drug development: regulatory science perspectives from the FDA
Dr. Járomi Luca
13 Industrial evaluation of drug transporters in ADME
Dr. Járomi Luca
14 The pharmacogenomics of membrane transporters I.
Dr. Járomi Luca
15 The pharmacogenomics of membrane transporters II.
Dr. Járomi Luca
16 Nucleoside transporters family
Dr. Járomi Luca
17 General characteristics of ABC-transporter family
Dr. Járomi Luca
18 Most relevant ones: ABC-transporters
Dr. Járomi Luca
19 P-glycoprotein (MDR1/ABCB1)
Dr. Járomi Luca
20 ABCG2
Dr. Járomi Luca
21 Cancer: exsorptive transporters (ABC) expressed on transformed cells
Dr. Járomi Luca
22 Proton-coupled nutrient transporters affect ADME properties
Dr. Járomi Luca
23 In vitro characterization of interactions with drug transporting proteins
Dr. Járomi Luca
24 In vivo characterization of interactions on transporters
Dr. Járomi Luca
25 Indication specific transporter studies
Dr. Járomi Luca
26 Future perspectives
Dr. Járomi Luca
27 Conclusions and outlook, summary
Dr. Járomi Luca
28 Exam
Dr. Járomi Luca
Practices
Seminars
Exam topics/questions
Introduction to world of drug transporters
General characteristics of drug transporters
Terms definition of drug transporters
Genetic role of drug transporters
Pharmacogenetic characteristics of drug transporters
Basics in phamacokinetics: definition of absorption, distribution, metabolism, and excretion (ADME)
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Explanation of absorption, distribution, metabolism, and excretion (ADME)
Membrane transporters in ADME I.
Membrane transporters in ADME II.
ADME pharmacogenomics in drug development I.
ADME pharmacogenomics in drug development II.
The role of transporters in drug development: regulatory science perspectives from the FDA
Industrial evaluation of drug transporters in ADME
The pharmacogenomics of membrane transporters I.
The pharmacogenomics of membrane transporters II.
Nucleoside transporters family
General characteristics of ABC-transporter family
Most relevant ones: ABC-transporters
P-glycoprotein (MDR1/ABCB1)
ABCG2
Cancer: exsorptive transporters (ABC) expressed on transformed cells
Proton-coupled nutrient transporters affect ADME properties
In vitro characterization of interactions with drug transporting proteins
In vivo characterization of interactions on transporters
Indication specific transporter studies
Future perspectives
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPF-EXT-T EXTRACTION AND CHROMATOGRAPHIC TECHNIQUES IN MEDICINAL PLANT ANALYSIS
Course director: DR. TÍMEA BENCSIK, assistant professor
Department of Pharmacognosy
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 6
Number of hours/semester: 26 lectures + 0 practices + 2 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 20 Prerequisites: OPA-MAN completed
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
With the increasing demand for herbal medicinal products, nutraceuticals, and natural products for health care all over the world,
medicinal plant extract manufacturers and essential oil producers have started using the most appropriate extraction and chromatographic
technologies in order to produce and standardize extracts and essential oils of defined quality. The aim of this course is to introduce the
most important extraction methods and chromatographic techniques used in the research of medicinal plants. Students should be able to
apply the acquired knowledge in their medical or pharmaceutical practice.
Task: To introduce state-of-the-art extraction techniques (maceration, infusion, digestion, decoction, percolation, Soxhlet, ultrasound
extraction, supercritical fluid extraction, water and steam distillation, enfleurage, expression) and chromatographic analyses (column
chromatography, thin layer chromatography, high pressure liquid chromatography) of medicinal plants and their role in the production
of herbal medicines. Some applications, relating to different classes of substances, are presented to demonstrate the versatility of various
chromatographic techniques.
Requirements: students have to know the most frequent extraction and analytical techniques used in medicinal and aromatic plant
research.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
One written exam during the semester, the acceptance level is 60%. One oral presentation by students.
Making up for missed classes
There is no possibility to make up for a missed lecture and practice.
Reading material
- Obligatory literature
- Literature developed by the Department
PowerPoint presentations prepared by lecturers.
- Notes
- Recommended literature
1. Handa S.S., Khanuja S.P.S., Longo G., Rakesh D.D.: Extraction Technologies for Medicinal and Aromatic Plants, International
Centre for Science and High Technology, Trieste, 2008
2. Reich E., Schibli A.: High-Performance Thin-Layer Chromatography for the Analysis of Medicinal Plants, Thieme, UK, 2007
3. Colegate S.M.: Bioactive Natural Products Detection Isolation and Structural Determination, CRC Press, 2008
4. Niessen W.M.A.: Liquid Chromatography - Mass Spectrometry, CRC Press, 2006
5. Nyiredy, Sz.: Planar Chromatography, Springer, Budapest, 2001.
6. Harris, DC.: Quantitative Chemical Analysis, WH. Freeman and Co., 7th edition, New York, 2007,
7. Schiedt K., Liaaen-Jensen S.: Isolation and Analysis, in Carotenoids Vol. 1A: Isolation and Analysis, Eds.: Britton G., Liaaen-
Jensen S., Pfander H., Birkhäuser Verlag, Basel, 1995.
Lectures
1 Introduction of the course requirements. An Overview of Extraction Techniques for Medicinal and Aromatic Plants.
Dr. Horváth Györgyi
2 Introduction of state-of-the-art extraction techniques: maceration, infusion, digestion, decoction, percolation, Soxhlet, ultrasound
extraction, supercritical fluid extraction, water and steam distillation, enfleurage, expression.
Dr. Horváth Györgyi
3 Introduction to Analytical Separations.
Dr. Benkő András Antal
4 Techniques for the Purposes of Botanical Research.
Dr. Benkő András Antal
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5 Planar Chromatography: TLC.
Dr. Benkő András Antal
6 Role of Different Procedures and Test Systems in the Knowledge of Herbal Substances.
Dr. Benkő András Antal
7 Column Chromatography Systems: GC.
Dr. Benkő András Antal
8 Column Chromatography Systems: HPLC.
Dr. Benkő András Antal
9 Detectors Used in Different Separation Techniques and their Role in Qualitative and Quantitative Analysis.
Dr. Benkő András Antal
10 Classification of Detectors Based on their Sensitivity and Selectivity.
Dr. Benkő András Antal
11 Role of thin layer chromatography (TLC) in detecting microbiological processes: TLC-Bioautography.
Dr. Horváth Györgyi
12 Antimicrobial activity of essential oils using TLC-Bioautography.
Dr. Horváth Györgyi
13 Isolation and identification of carotenoids from medicinal plants.
Dr. Molnár Péter
14 Role of column liquid chromatography (CLC) in carotenoid research.
Dr. Molnár Péter
15 Examination of honeys, sugars, polyphenols.
Dr. Farkas Ágnes
16 Examination of honeys, sugars, polyphenols.
Dr. Farkas Ágnes
17 Identification of specific metabolites in herbal products. Adulterated dietary supplements.
Dr. Bencsik Tímea
18 Identification of specific metabolites in herbal products with TLC.
Dr. Bencsik Tímea
19 Isolation and Identification of flavonoids in medicinal plants.
Dr. Papp Nóra
20 Isolation and Identification of flavonoids in medicinal plants.
Dr. Papp Nóra
21 Quality of herbal products; our experiences in the Department of Pharmacognosy.
Dr. Bencsik Tímea
22 Quality of herbal products; our experiences in the Department of Pharmacognosy.
Dr. Bencsik Tímea
23 Student’s lecture.
Dr. Bencsik Tímea
24 Student’s lecture.
Dr. Bencsik Tímea
25 Written test.
Dr. Horváth Györgyi
26 Written test.
Dr. Horváth Györgyi
Practices
Seminars
1 Chromatographic seminar: TLC.
2 Chromatographic seminar: HPLC.
Exam topics/questions
The topics of the 1 written test are similar to the topics of the lectures.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Bencsik Tímea (BETMACO.PTE), Dr. Benkő András Antal (BEAQAAP.PTE)
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OPF-KNH-T DRUG PLANTS AND HALLUCINOGENES
Course director: DR. GYÖRGYI HORVÁTH, associate professor
Department of Pharmacognosy
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 6
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPA-GN2 completed
Topic
The course includes 28 lectures. The aim of the course is to present the most commonly used psychoactive plants and hallucionogens
around the world. The course gives a general overview about the botanical character and medicinal value of the most frequent plants and
fungi. In addition legal regulation, international guidelines for their control and the problem of addiction are also discussed.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Fulfillment of the final test (minimum 60%).
Making up for missed classes
Downloading of lectures in Neptun.
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
Ratsch C., Hofmann A.(2007): The Encyclopedia of Psychoactive Plants: Ethnopharmacology and Its Applications.
McKenna D. (2018): Ethnopharmacologic Search for Psychoactive Drugs (Vol. 1 & 2): 50 Years of Research.
Schultes R.E. (2001): Plants of the Gods: Their Sacred, Healing, and Hallucinogenic Powers.
Willis C.(2015): Hallucinogens: The Truth About Hallucinogenic Plants.
Meuninck J. (2014): Basic Illustrated Poisonous and Psychoactive Plants.
Lectures
1 Attitude of psychoactive drugs in Hungary and Europe.
Dr. Ács Kamilla
2 Classification of psychoactive drugs: psychedelics, dissociatives and deliriants. Drug or medication?
Dr. Ács Kamilla
3 Opium and opiates around the world I.: Middle East, Western-, Middle- and South Asia
Dr. Ács Kamilla
4 Opium and opiates around the world II.: Southeast Asia, Europe, America
Dr. Ács Kamilla
5 Poppy seed (Papaver somniferum): legal use
Dr. Ács Kamilla
6 Poppy seed (Papaver somniferum): illegal use
Dr. Ács Kamilla
7 History of international audit of psychoactive drugs
Dr. Ács Kamilla
8 International guidelines for the control of psychoactive substances
Dr. Ács Kamilla
9 Synthetic opioids
Dr. Ács Kamilla
10 Detection of synthetic and plant originated hallucinogens. Analytics of psychoactive agents.
Dr. Ács Kamilla
11 Hallucinogenic plants I.: Solanaceae species
Dr. Ács Kamilla
12 Hallucinogenic plants II.: Ergot
Dr. Ács Kamilla
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13 Hallucinogenic plants III.: Plants from Asia
Dr. Ács Kamilla
14 Hallucinogenic plants IV.: Plants from South-America
Dr. Ács Kamilla
15 Hallucinogenic fungi
Dr. Ács Kamilla
16 Medicinal use of psychoactive plants I.: Erythroxylum coca
Dr. Ács Kamilla
17 Medicinal use of psychoactive plants II.: Catha edulis I.
Dr. Ács Kamilla
18 Medicinal use of psychoactive plants II.: Catha edulis II.
Dr. Ács Kamilla
19 Medicinal use of psychoactive plants III.: Ephedraceae I.
Dr. Ács Kamilla
20 Medicinal use of psychoactive plants III.: Ephedraceae II.
Dr. Ács Kamilla
21 Medicinal use of psychoactive plants IV: Cannabis sativa indica I.
Dr. Ács Kamilla
22 Medicinal use of psychoactive plants IV: Cannabis sativa indica II.
Dr. Ács Kamilla
23 Legalization of psychoactive agents I.
Dr. Ács Kamilla
24 Illegal drugs in criminal investigations.
Dr. Ács Kamilla
25 Drug abuse and addiction I.
Dr. Ács Kamilla
26 Drug abuse and addiction II.
Dr. Ács Kamilla
27 Exam
Dr. Ács Kamilla
28 Exam
Dr. Ács Kamilla
Practices
Seminars
Exam topics/questions
Topics include the lectures of the semester.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPF-MMG-T NUCLEAR MAGNETIC RESONANCE IN DRUG DEVELOPMENT
Course director: DR. ZOLTÁN BERENTE, associate professor
Department of Biochemistry and Medical Chemistry
1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 6
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 3 – 20 Prerequisites: OPA-BA2 parallel + OPA-MAN parallel
Topic
The course provides an insight into the process of drug development through examples that involve nuclear magnetic resonance as an
analytical tool. The method is extensively applied at numerous different points of the process, due to its versatility.
The course will discuss, after a brief theoretical introduction, the study of structure determination and structure-activity relationship of
drug candidate molecules. In the second phase the course will discuss some (mostly in vivo) applications used for the investigation of
the efficacy of drug candidates in various animal models.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Presentation of a home project is required.
Making up for missed classes
On the judgement of the course director.
Reading material
- Obligatory literature
None
- Literature developed by the Department
See Neptun Meet Street
- Notes
See Neptun Meet Street
- Recommended literature
R. A. de Graaf: In vivo NMR Spectroscopy, Wiley, 1998
N. Beckman: In vivo MR Techniques in Drug Discovery and Development, Taylor and Francis, 2006
http://cis.rit.edu/htbooks/nmr
http://cis.rit.edu/htbooks/mri
http://www.imaios.com/en/e-Courses/e-MRI
http://www.magnetic-resonance.org/
http://eprints.drcmr.dk/37/1/MRI_English_a4.pdf
Lectures
1 The NMR phenomenon, excitation and signal formation, relaxation
Dr. Berente Zoltán
2 Theory and practice of the Fourier-transform pulse NMR
Dr. Berente Zoltán
3 Basics of MR imaging
Dr. Berente Zoltán
4 MR methods in the drug development process
Dr. Berente Zoltán
5 Role of MR-based biomarkers in decision making during drug development
Dr. Berente Zoltán
6 Structure determination of small molecules using NMR
Dr. Berente Zoltán
7 Structure determination of biomolecules using NMR
Dr. Berente Zoltán
8 Structure-activity-relationships using NMR
Dr. Berente Zoltán
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9 MR contrast agents
Dr. Berente Zoltán
10 MR studies of diabetes, obesity and inflammation models
Dr. Berente Zoltán
11 MR studies of stroke, MS and neurodegenerative disease models
Dr. Berente Zoltán
12 MR studies of preclinical tumor models
Dr. Berente Zoltán
13 MR studies of CV and lung disease models
Dr. Berente Zoltán
14 Project presentations
Dr. Berente Zoltán
Practices
Seminars
Exam topics/questions
-
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPF-PNT-T PHARMACEUTICAL NANOTECHNOLOGY
Course director: Dr. Aleksandar SECENJI, senior research fellow
Institute of Pharmaceutical Technology and Biopharmacy
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 6
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPG-GT1-T completed
Topic
Nanotechnology is a multidisciplinary discipline, which is the approach of the production of materials, structures, and systems, in which
the material is handled and produced in nanometers i.e. in a billionth of a meter. Pharmaceutical nanotechnology is the application of
nanotechnology in the pharmaceutical industry in life and health sciences and is base for the development of nanostructured modern drug
delivery systems for therapeutic purposes as well as advanced diagnostic biosensors dealing with early detection of diseases
The aim of the course is to provide a comprehensive picture of the application of nanotechnology in drug development and
pharmaceuticals. A brief introduction to the history, role, and impact of nanotechnology on state-of-the-art technologies. The properties
of specific physicochemical properties of nanomaterials can be explained by the well-known thermodynamic principles. Because of the
small size, the surface and the quantum effects play a prominent role, the theoretical basis of which is presented. Hereinafter, the
classification of nanoscale medicines and their detailed presentation will be presented.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
1 written test
Making up for missed classes
not needed
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
1. Nanotechnology in Drug Delivery, Melgardt M. de Villiers, Pornanong Aramwit, Glen S. Kwon, Springer, DOI: 10.1007/978-
0-387-77667-5
2. Pharmaceutical Nanotechnology: Fundamentals and Practical Applications, Costas Demetzos, ADIS, DOI 10.1007/978-981-
10-0791-0
3. Pharmaceutical Nanotechnology: Innovation and Production, Jean Cornier, Andrew Owen, Arno Kwade, and Marcel Van de
Voorde, WILEY-VCH, Print ISBN: 978-3-527-34054-5, ePDF ISBN: 978-3-527-80067-4
Lectures
1 Introduction to Nanotechnology
Dr. Secenji Aleksandar
2 Introduction to Nanotechnology
Dr. Secenji Aleksandar
3 Theoretical basics of nanotechnology
Dr. Secenji Aleksandar
4 Theoretical basics of nanotechnology
Dr. Secenji Aleksandar
5 Drug nanocarriers classification
Dr. Secenji Aleksandar
6 Drug nanocarriers classification
Dr. Secenji Aleksandar
7 Inorganic nanostructures
Dr. Secenji Aleksandar
8 Inorganic nanostructures
Dr. Secenji Aleksandar
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9 Organic nanostructures
Dr. Secenji Aleksandar
10 Organic nanostructures
Dr. Secenji Aleksandar
11 Pharmaceutical nanocrystals
Dr. Secenji Aleksandar
12 Pharmaceutical nanocrystals
Dr. Secenji Aleksandar
13 Matrix Systems
Dr. Secenji Aleksandar
14 Matrix Systems
Dr. Secenji Aleksandar
15 Porous systems
Dr. Secenji Aleksandar
16 Porous systems
Dr. Secenji Aleksandar
17 Binding, filling, trapping and releasing the drug from nanostructures
Dr. Secenji Aleksandar
18 Binding, filling, trapping and releasing the drug from nanostructures
Dr. Secenji Aleksandar
19 Hydrophobic drugs
Dr. Secenji Aleksandar
20 Hydrophobic drug
Dr. Secenji Aleksandar
21 Hydrophilic drugs
Dr. Secenji Aleksandar
22 Hydrophilic drugs
Dr. Secenji Aleksandar
23 Makromolecular drug carriers
Dr. Secenji Aleksandar
24 Makromolecular drug carriers
Dr. Secenji Aleksandar
25 Vesicular drug delivery systems
Dr. Secenji Aleksandar
26 Vesicular drug delivery systems
Dr. Secenji Aleksandar
27 Nano Emulsions, Pickering Emulsions
Dr. Secenji Aleksandar
28 Nano Emulsions Pickering Emulsions
Dr. Secenji Aleksandar
Practices
Seminars
Exam topics/questions
1. Introduction to Nanotechnology
2. Theoretical basics of nanotechnology
3. Drug nanocarriers classification
4. Inorganic nanostructures
5. Organic nanostructures
6. Pharmaceutical nanocrystals
7. Matrix Systems
8. Porous systems
9. Binding, filling, trapping and releasing the drug from nanostructures
10. Hydrophobic drug
11. Hydrophilic drugs
12. Makromolecular drug carriers
13. Vesicular drug delivery systems
14. Nano Emulsions Pickering Emulsions
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Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
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OPF-SNA-T CARBON NANOSTRUCTURES
Course director: DR. BEÁTA LEMLI, assistant professor
Department of Pharmaceutical Chemistry
2 credit ▪ midsemester grade ▪ Elective subject for the Pharmaceutical module ▪ spring semester ▪ recommended semester: 6
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 20 Prerequisites: OPG-GK1-T completed + OPG-R1E-T completed
Topic
Carbon is an indispensable element of life, thanks to the ability to form different chemical bonds with most elements of the periodic
table, enabling the creation of different and complex life forms. The discovery of the organic carbon compounds has been started in the
19th century, and now they are the part of our lives. Nowadays the previously discovered allotropes of carbon - fullerenes, carbon
nanotubes, graphenes, graphene nanoribbons - are in the focus, however, their real wide application still seems to be a big challenge and
needs further investigations. During this curse, students will be introduced to the promising pharmaceutical chemistry, medical and
biological applications of these materials and to the latest results of related research.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
One written exam during the semester, the acceptance level is 60%. One oral presentation by students.
Making up for missed classes
There is no possibility to make up for a missed lecture and practice
Reading material
- Obligatory literature
Physical Biochemistry: Applications to Biochemistry and Molecular Biology (Life Sciences/Biochemistry) by David M. Freifelder,
2nd Edition, ISBN-13: 978-0716714446, ISBN-10: 0716714442
- Literature developed by the Department
The slides of the lectures are electronically available.
- Notes
- Recommended literature
Physical Biochemistry: Applications to Biochemistry and Molecular Biology (Life Sciences/Biochemistry) by David M. Freifelder,
2nd Edition, ISBN-13: 978-0716714446, ISBN-10: 0716714442
Lectures
1 Introduction of the course requirements. Fullerenes, carbon nanostructure, graphene: their discovery, historical review
Dr. Lemli Beáta
2 Introduction of the course requirements. Fullerenes, carbon nanostructure, graphene: their discovery, historical review
Dr. Lemli Beáta
3 Preparation, synthesis, cleaning, general properties
Dr. Lemli Beáta
4 Preparation, synthesis, cleaning, general properties
Dr. Lemli Beáta
5 Covalent and non-covalent functionalization of carbon nanomaterials
Dr. Lemli Beáta
6 Covalent and non-covalent functionalization of carbon nanomaterials
Dr. Lemli Beáta
7 Cellular uptake mechanism of carbon nanotubes
Dr. Lemli Beáta
8 Cellular uptake mechanism of carbon nanotubes
Dr. Lemli Beáta
9 Carbon nanotube biodistribution
Dr. Lemli Beáta
10 Carbon nanotube biodistribution
Dr. Lemli Beáta
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11 Application of carbon nanocapsules in drug delivery
Dr. Lemli Beáta
12 Application of carbon nanocapsules in drug delivery
Dr. Lemli Beáta
13 Carbon nanotubes applied for in vitro, in vivo and in silico drug delivery
Dr. Lemli Beáta
14 Carbon nanotubes applied for in vitro, in vivo and in silico drug delivery
Dr. Lemli Beáta
15 Carbon nanostructures and DNA
Dr. Lemli Beáta
16 Carbon nanostructures and DNA
Dr. Lemli Beáta
17 Novel strategies for cancer diagnosis and treatment
Dr. Lemli Beáta
18 Novel strategies for cancer diagnosis and treatment
Dr. Lemli Beáta
19 The toxicity of carbon nanomaterials
Dr. Lemli Beáta
20 The toxicity of carbon nanomaterials
Dr. Lemli Beáta
21 Outlook: about the nanomedicines and drug delivery nanosystems
Dr. Lemli Beáta
22 Outlook: about the nanomedicines and drug delivery nanosystems
Dr. Lemli Beáta
23 Student’s lecture.
Dr. Lemli Beáta
24 Student’s lecture.
Dr. Lemli Beáta
25 Written test.
Dr. Lemli Beáta
26 Written test.
Dr. Lemli Beáta
27 Summary and conclusions
Dr. Lemli Beáta
28 Summary and conclusions
Dr. Lemli Beáta
Practices
Seminars
Exam topics/questions
The topics of the written test are similar to the topics of the lectures.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPE-FM2-T DATA ANALYSIS 2
Course director: DR. LÁSZLÓ PÓTÓ, associate professor
Institute of Bioanalysis
1 credit ▪ midsemester grade ▪ Elective subject ▪ autumn semester ▪ recommended semester: 7
Number of hours/semester: 7 lectures + 7 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 1 – 12 Prerequisites: OPE-FMA parallel
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The goal of this course is to help students to prepare for thesis writing or making their own student research project. It covers two fields
of that job: the practice of data collection and prepare data for the analysis as well as the performing the analysis based on the preliminary
analysis plan. Shortly to say: How to perform the data collection and analysis of your own study project. (This course can be the
continuation of the ‘Data analysis 1’ course however someone can complete these two courses on a reversed order as well. The main
reason of this flexibility is, that many students are asking for help when they have already had their data at hands (at least partially), and
this course is processing the steps from this point of the job. Even though, it is beneficial for the students doing this course first to
complete the Data analysis 1 course later. They can do it next year for example - so to understand the preliminary steps of a research
work: How to make a research plan?)
This course is also based on the medical papers. Students may pick the appropriate data collection methods and recognize the critical
points of this process based on the most fundamental papers of their own research field. They can learn from the most rewarded experts
on this way. From a paper you may extract the principles as well as you can follow immediately the realization. It is an excellent way to
learn the methodology. You may even learn from the errors.
The same way is followed for the data analysis and making conclusions. Every student will do his/her own data analysis based on their
own plan.
Students will have all help to the practical evaluation of their own data and making the right conclusion. The steps and results will be
discussed and improved by a class discussion.
Conditions for acceptance of the semester
Maximum 1 lesson absence.
Mid-term exams
Evaluate your data step by step and present it to the group weekly.
Making up for missed classes
One extra class
Reading material
- Obligatory literature
1-3 medical papers brought by each student (from library, from your department or from the tutor of your thesis).
- Literature developed by the Department
Supporting materials (papers, posters, research reports, ...) supplied by the tutor of the classes.
- Notes
- Recommended literature
Any statistical books.
Lectures
1 Introduction. Find a paper to process. Prepare or present your own data collection plan.
Dr. Pótó László
2 The realization of the data collection - examples are based on papers
Dr. Pótó László
3 The preliminary data preparations for the following statistical analysis.
Dr. Pótó László
4 Do your own statistical analysis 1 - select the right methods
Dr. Pótó László
5 Do your own statistical analysis 2 - interpret the results.
Dr. Pótó László
6 Make your conclusion and share the results with the others.
Dr. Pótó László
7 Summary. Consolidation and evaluation of the results.
Dr. Pótó László
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Practices
1 Find a paper to process. Work on your own data collection plan.
2 Present the realization of the data collection - based on selected papers
3 Share your experiences on your preliminary data preparations - make corrections if needed.
4 Present your own statistical analysis 1 - methods and results 1
5 Continue - methods and results 2
6 Make your conclusion and share the results with the others.
7 Overview and summarize the results of the class.
Seminars
Exam topics/questions
Evaluate your data and submit your own results based on your active participation.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Pótó László (POLGABO.PTE)
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OPE-FMA-T DATA ANALYSIS 1
Course director: DR. LÁSZLÓ PÓTÓ, associate professor
Institute of Bioanalysis
1 credit ▪ midsemester grade ▪ Elective subject ▪ autumn semester ▪ recommended semester: 7
Number of hours/semester: 7 lectures + 7 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 1 – 12 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The goal of this course is to help students to prepare for thesis writing or making their own student research project. It covers mainly two
fields of that: read and interpret scientific papers and prepare an own study plan. Shortly to say: How to prepare for your own study
project.
Block One: The medical papers are likely the most important source to improve your present knowledge as a student and as an
MD. Most of these ‘original papers’ are based on carefully planned data collection and evaluation applying a wide array of statistical
methods. It is essential to be familiar with this methodology so to understand these papers. But you may learn these steps and methods
from the papers since all are based on the rules of designing scientific research projects. From a paper you may extract the principles as
well as you can follow immediately the realization. It is an excellent way to learn the methodology. You may even learn from the errors.
Block Two: Apply all these for your own research: make a study plan. It should include your study goal the extent and way of
your data collection the preliminary data processing the way of data analysis and the way of conclusion making.
Based on this outline you will prepare your own study design on your own student’s research work or on your thesis job. If you have no
such project at the moment you may construct an own „sample study plan” that can be a working model for your future thesis work. You
will have all help to find your own project and complete the plan in the practice if you need. All of your personal design elements will
be discussed and improved by a class discussion.
The practical realization of your study will be supported by the Data analysis 2 course.
Conditions for acceptance of the semester
Maximum 1 lesson absence.
Mid-term exams
Prepare and submit your own study plan step-by-step and present sortly weekly to the group - based on your active participation.
Making up for missed classes
One extra class
Reading material
- Obligatory literature
1-3 medical papers brought by each student (from library, from your department or from the tutor of your thesis).
- Literature developed by the Department
Other supporting materials supplied by the tutor of the classes.
- Notes
- Recommended literature
Any statistical books on study design and data analysis.
Lectures
1 Introduction. Find a paper to process. Find your own study.
Dr. Pótó László
2 The goal of your study - based on a demo paper
Dr. Pótó László
3 The main- and ‘sub-’hypotheses of the study.
Dr. Pótó László
4 Finding your sample frame - based on your hypotheses.
Dr. Pótó László
5 The research design and the methods of the data collection. How many data should be collected?
Dr. Pótó László
6 Creating the plan of the data analysis.
Dr. Pótó László
7 The complete study plan.
Dr. Pótó László
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Practices
1 Introduction. Overview of some sample papers.
2 The goal of your study - processing a few papers brought and presented by students.
3 Setting the study hypotheses. Further analysis of the papers.
4 Which data should you collect and how to do that.
5 Finalize the plan of your data collection.
6 Make a plan of the data processing.
7 Create, present and discuss of your study plan.
Seminars
Exam topics/questions
Preparation of the study plan
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Pótó László (POLGABO.PTE)
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OPE-SHK-T DESIGN AND INDUSTRIAL MANUFACTURE OF MEDICINES
Course director: DR. SZILÁRD PÁL, assistant professor
Institute of Pharmaceutical Technology and Biopharmacy
2 credit ▪ midsemester grade ▪ Elective subject for the Pharmaceutical module ▪ autumn semester ▪ recommended semester: 7
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPG-BFM completed + OPG-GT2 completed
Topic
During the course, the process of the design of modified drug delivery systems is acquired by the students based on the theory and
practice of biopharmaceutical including examinations of dosage forms. The course consists of theoretical lectures and seminars.
Conditions for acceptance of the semester
- participation on the lectures
- accepted work reports
- accepted written assessments
Mid-term exams
Students have to write an end-semester assessment from the lectures at acceptance level of 60%.
Making up for missed classes
Students must fulfil requirements determined by the Code of Studies and Examinations. Student has make up for the missed lectures and
work reports.
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
Leon Shargel, A. B.C. Yu, Stamford: Applied Biopharmaceutics and Pharmacokinetics
Susanna Wu-Pong, Yon Rojanasakul: Biopharmaceutical Drug Design and Development, Humana Press
Gilbert S. Banker, Christopher T. Rhodes: Modern Pharmaceutics, Marcel Dekker Inc., New York- Basel
Michael J. Rathbone, Michael S. Roberts: Modified-Release Drug Delivery Technology, Informa Healthcare
Michael E. Aulton: The Design and Manufacture of Medicines, Churchill Livingstone
Lectures
1 Floating drug delivery, Targeted Drug Delivery Systems
Dr. Pál Szilárd
2 Floating drug delivery, Targeted Drug Delivery Systems
Dr. Pál Szilárd
3 Floating drug delivery, Targeted Drug Delivery Systems
Dr. Pál Szilárd
4 Floating drug delivery, Targeted Drug Delivery Systems
Dr. Pál Szilárd
5 Introduction of modified drug delivery
Dr. Kása Péter
6 Introduction of modified drug delivery
Dr. Kása Péter
7 Introduction of modified drug delivery
Dr. Kása Péter
8 Introduction of modified drug delivery
Dr. Kása Péter
9 Targeted Drug Delivery Systems
Dr. Secenji Aleksandar
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10 Targeted Drug Delivery Systems
Dr. Secenji Aleksandar
11 Targeted Drug Delivery Systems
Dr. Pál Szilárd
12 Targeted Drug Delivery Systems
Dr. Pál Szilárd
13 Pulsative Drug Delivery Systems
Dr. Pál Szilárd
14 Pulsative Drug Delivery Systems
Dr. Pál Szilárd
15 Pulsative Drug Delivery Systems
Dr. Pál Szilárd
16 Pulsative Drug Delivery Systems
Dr. Pál Szilárd
17 Dissolution, lecture and practice
Ámanné Dr. Takácsi-Nagy Anna
18 Dissolution, lecture and practice
Ámanné Dr. Takácsi-Nagy Anna
19 Dissolution, lecture and practice
Dr. Pál Szilárd
20 Dissolution, lecture and practice
Dr. Pál Szilárd
21 From molecule to the preparition
Dr. Kása Péter
22 From molecule to the preparition
Dr. Kása Péter
23 From molecule to the preparition
Dr. Pál Szilárd
24 From molecule to the preparition
Dr. Pál Szilárd
25 Test
Dr. Pál Szilárd
26 Test
Dr. Pál Szilárd
27 Assessment
Dr. Pál Szilárd
28 Assessment
Dr. Pál Szilárd
Practices
Seminars
Exam topics/questions
Students can get the test topics in the institute or download the from website of the institute.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Dévay Attila (DEAHABO.PTE), Dr. Pál Szilárd (PASMAAO.PTE)
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OPE-T2F-T PHARMACEUTICAL BIOTECHNOLOGY AND ITS LINKS TO BIOPHARMACEUTICALS
Course director: DR. JUDIT PONGRÁCZ, professor
Department of Pharmaceutical Biotechnology
3 credit ▪ midsemester grade ▪ Elective subject for the Pharmaceutical module ▪ autumn semester ▪ recommended semester: 7
Number of hours/semester: 28 lectures + 14 practices + 0 seminars = total of 42 hours
Course headcount limitations (min.-max.): 5 – 50 Prerequisites: none
Topic
The aim of this course is to introduce students to the science of pharmaceutical biotechnology and its links to biopharmaceuticals.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Writing test
Making up for missed classes
According to the Code of Studies and Examinations
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
Lecture notes, lecture materials available on MeetStreet
- Recommended literature
Lectures
1 Pharmaceuticals, biologics and biopharmaceuticals - link to Biotechnology. An introduction.
Dr. Kvell Krisztián
2 Protein structure and its importance of engineering biopharmaceuticals
Dr. Kvell Krisztián
3 Gene manipulation and recombinant DNA technology 1: Nucleic acid manipulation
Dr. Kvell Krisztián
4 Gene manipulation and recombinant DNA technology 2: Recombinant production of therapeutic proteins.
Dr. Kvell Krisztián
5 Gene manipulation and recombinant DNA technology 3: Nucleic acid manipulation.
Dr. Kvell Krisztián
6 Biotechnological methodology in drug development 1
Dr. Pongrácz Judit
7 Biotechnological methodology in drug development 2
Dr. Pongrácz Judit
8 Biotechnological methodology in drug development 3
Dr. Pongrácz Judit
9 Sources and upstream processing 1
Dr. Pongrácz Judit
10 Sources and upstream processing 2
Dr. Pongrácz Judit
11 Downstream processing 1
Dr. Járomi Luca
12 Downstream processing 2
Dr. Járomi Luca
13 Product analysis
Dr. Járomi Luca
14 The cytokines: the interferon family
Dr. Járomi Luca
15 Cytokines: Interleukin and tumor necrosis factor
Dr. Járomi Luca
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16 Growth factors
Dr. Pongrácz Judit
17 Therapeutic hormones
Dr. Pongrácz Judit
18 Recombinant blood proteins and therapeutic enzymes
Dr. Pongrácz Judit
19 Antibodies in diagnostics and therapy
Dr. Pongrácz Judit
20 Vaccines and adjuvants
Dr. Pongrácz Judit
21 Vaccine production
Dr. Pongrácz Judit
22 Nucleic acid-based therapeutics. Gene therapy.
Dr. Kvell Krisztián
23 Nucleic acid-based therapeutics. Recombinant viruses in cancer therapy.
Dr. Pongrácz Judit
24 Cell-based therapeutics
Dr. Kvell Krisztián
25 Test systems for toxicology
Dr. Járomi Luca
26 Test systems for efficacy
Dr. Járomi Luca
27 Nanotechnology
Dr. Pongrácz Judit
28 Legal aspects of healthcare-related Biotechnology
Dr. Pongrácz Judit
Practices
1 Principals of gene cloning - using the NCBI database
2 Cloning a specific gene - a practical approach 1
3 Cloning a specific gene - a practical approach 2
4 Cloning a specific gene - a practical approach 3
5 Culturing organisms for protein production
6 Culturing organisms for protein production
7 Selection and application of organisms for protein production
8 Protein purification for therapeutic application 1
9 Protein purification for therapeutic application 2
10 Technical approach for monoclonal antibody production 1
11 Technical approach for monoclonal antibody production 2
12 Testing toxicity using methodology of biotechnology
13 Efficacy testing using methodology of biotechnology
14 Nanotechnological methods
Seminars
Exam topics/questions
MeetStreet
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Járomi Luca (JALGAAT.PTE), Dr. Kvell Krisztián (KVKFAAO.PTE)
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OPF-KIA-T ESSENTIAL OILS AND CLINICAL AROMATHERAPY
Course director: DR. GYÖRGYI HORVÁTH, associate professor
Department of Pharmacognosy
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 7
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 3 – 50 Prerequisites: OPG-FG1 completed + OPG-FG2 completed
Topic
Essential oils (EOs) are very interesting natural products and among other qualities they possess various biological properties. The term
biological comprises to all activities that these mixtures of volatile compounds (mainly mono- and sesquiterpenoids, phenylpropanoids,
etc.) exert on humans. EOs are used for their therapeutic action, for flavouring, in perfumery, or as starting materials for the synthesis of
other compounds. For therapeutic purposes they are administered as inhalations (e.g. eucalyptus oil), orally (e.g. peppermint oil) and
transdermally (e.g. rosmary oil). Oils with a high phenol content, for instance thyme and clove, have antiseptic properties, whereas others
are used as carrminatives. Oils showing antispasmodic activity, and much used in popular medicine, are those of melissa, peppermint,
chamomile, fennel, caraway and orange. Furthermore, in traditional medicine, EOs are also well-known for their analeptic, antimicrobial,
antinociceptive, antiphlogistic, antioxidative and sedative activities. All terpenoids easily enter the human body by oral absorption,
penetration through the skin, or inhalation very often leading to measurable blood concentrations. The aim of this course is to introduce
the most important medicinal plants containing essential oils and their medicinal role in the therapy and the clinical aromatherapy. We
would like to highlight their appropriate use, their profiles, but to call students’ attention to the cautions and contraindications of EOs, as
well.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Two written exams during the semester, acceptance of them from 60%.
Making up for missed classes
There is no possibility.
Reading material
- Obligatory literature
- Literature developed by the Department
PowerPoint presentations prepared by lecturers.
- Notes
- Recommended literature
1. Evans W.C.: Trease and Evans Pharmacognosy, Saunders, London, New York, 2000
2. Tisserand R., Balacs T.: Essential Oil Safety: A Guide for Health Care Professionals, Churchill Livingstone, 1995
3. Tisserand R., Young R: Essential Oil Safety: A Guide for Health Care Professionals, Second edition, Churchill Livingstone, 2013
Baser C.H, Buchbauer G.: Handbook of Essential Oils. Science, Technology and Application. CRC Press, Boca Raton, 2010
Lectures
1 Introduction of the course requirements. Definition of aromatherapy and clinical aromatherapy.
Dr. Horváth Györgyi
2 Advantages and disadvantages of the application of essential oils.
Dr. Horváth Györgyi
3 History of the use of essential oils.
Dr. Horváth Györgyi
4 Biological activities of essential oils.
Dr. Horváth Györgyi
5 Sources of essential oils.
Dr. Horváth Györgyi
6 Chemistry of essential oils. Chemical composition of essential oils.
Dr. Horváth Györgyi
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7 Extraction techniques of essential oils: water-steam distillation, enfleurage, expression, supercritical fluid extraction. Gas
chromatographic analysis of essential oils.
Dr. Horváth Györgyi
8 Extraction techniques of essential oils: water-steam distillation, enfleurage, expression, supercritical fluid extraction. Gas
chromatographic analysis of essential oils.
Dr. Horváth Györgyi
9 Drugs containing essential oils in the European Pharmacopoeia and in the ESCOP Monograph.
Dr. Horváth Györgyi
10 Quality of essential oils according to the official Pharmacopoeias.
Dr. Horváth Györgyi
11 External application of essential oils.
Dr. Horváth Györgyi
12 The most important base oils.
Dr. Horváth Györgyi
13 Physiological effects of essential oils. Metabolism of essential oil components in animal models and humans.
Dr. Horváth Györgyi
14 Contraindications.
Dr. Horváth Györgyi
15 Written test I
Dr. Horváth Györgyi
16 Written test I
Dr. Horváth Györgyi
17 Antimicrobial activity of essential oils. In vitro methods.
Dr. Horváth Györgyi
18 Antimicrobial activity of essential oils. In vivo methods.
Dr. Horváth Györgyi
19 Description of essential oils I: their main components and medicinal use. Peppermint oil, lemon oil, citronella oil, pine oil,
lavender oil.
Dr. Horváth Györgyi
20 Description of essential oils I: their main components and medicinal use. Peppermint oil, lemon oil, citronella oil, pine oil,
lavender oil.
Dr. Horváth Györgyi
21 Description of essential oils II: their main components and medicinal use. Clary sage oil, rosemary oil, tea tree oil, clove oil,
thyme oil, chamomile oil.
Dr. Horváth Györgyi
22 Description of essential oils II: their main components and medicinal use. Clary sage oil, rosemary oil, tea tree oil, clove oil,
thyme oil, chamomile oil.
Dr. Horváth Györgyi
23 Description of essential oils II.: their main components and medicinal use. Cinnamon oil, bitter and sweet orange oil, anise oil,
carraway oil, eucalyptus oil, sweet fennel oil, spearmint oil.
Dr. Horváth Györgyi
24 Description of essential oils II.: their main components and medicinal use. Cinnamon oil, bitter and sweet orange oil, anise oil,
carraway oil, eucalyptus oil, sweet fennel oil, spearmint oil.
Dr. Horváth Györgyi
25 Safety guidelines of essential oils.
Dr. Horváth Györgyi
26 Safety guidelines of essential oils.
Dr. Horváth Györgyi
27 Written test II
Dr. Horváth Györgyi
28 Written test II
Dr. Horváth Györgyi
Practices
Seminars
Exam topics/questions
There is no list. The questions of the written test is similar to the lecture topics.
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Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPF-XES-T THE FATE OF DRUG
Course director: Dr. Orsolya RIDEG, research associate professor
Department of Pharmaceutical Biotechnology
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 7
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPG-GK1-T completed
Topic
By the end of the course, the students get an outlook on the history and basics of genetics and pharmacogenetics.They get an outlook on
the newest methodical aspects of genetic variants and enzyme function. By discussing certain clinical cases (mostly clinical cases from
the central nervous system, pulmonology, and hepatology) students get an outlook on the importance and complexity of the area.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
One test at the end of the course.
Making up for missed classes
No option for supplement.
Reading material
- Obligatory literature
- Literature developed by the Department
Educational material in PDF
- Notes
- Recommended literature
Genetic Variation: Methods and Protocols; Barnes Michael R.; Springer
Concepts and tools in Pharmacogenomics - FDA
Principles of Pharmacogenetics and Pharmacogenomics; Rus B. Altman;Cambridge
Lectures
1 Basics on Genetics and Pharmacology, History of Pharmacogenetics
Dr. Rideg Orsolya
2 Basics on Genetics and Pharmacology, History of Pharmacogenetics
Dr. Rideg Orsolya
3 Biotransformation; Phase I enzymes: focusing on the liver (function, genetic, case studies)
Dr. Rideg Orsolya
4 Biotransformation; Phase I enzymes: focusing on the liver (function, genetic, case studies)
Dr. Rideg Orsolya
5 Biotransformation; Phase II enzymes: focusing on the liver (function, genetic, case studies)
Dr. Rideg Orsolya
6 Biotransformation; Phase II enzymes: focusing on the liver (function, genetic, case studies)
Dr. Rideg Orsolya
7 Expression and regulation of xenobiotic Metabolizing Cytochrome P450 Enzymes in the Central Nervus System
Dr. Rideg Orsolya
8 Expression and regulation of xenobiotic Metabolizing Cytochrome P450 Enzymes in the Central Nervus System (case study)
Dr. Rideg Orsolya
9 Expression and regulation of xenobiotic Metabolizing Cytochrome P450 Enzymes in the Lung
Dr. Rideg Orsolya
10 Expression and regulation of xenobiotic Metabolizing Cytochrome P450 Enzymes in the Lung (case study)
Dr. Rideg Orsolya
11 Role of CYP genepolymorphisms’ in neurological and cardiological diseases.
Dr. Rideg Orsolya
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12 Methodical aspects of genetic variants
Dr. Rideg Orsolya
13 Methodical aspects of enzyme function.
Dr. Rideg Orsolya
14 Test
Dr. Rideg Orsolya
Practices
Seminars
Exam topics/questions
-
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPE-FAJ-T PAIN AND ANALGESICS
Course director: DR. GÁBOR PETHŐ, professor
Department of Pharmacology and Pharmacotherapy
1 credit ▪ midsemester grade ▪ Elective subject for the Pharmaceutical module ▪ spring semester ▪ recommended semester: 8
Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours
Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPG-GH1 completed
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The aim of the course is to give an integrative overview on the physiological, pathophysiological and pharmacological aspects of pain.
Major tasks are to (i) provide information on peripheral and central mechanisms of pain and hyperalgesia; (ii) describe the major features
of existing analgesics including opioids, non-steroidal antiinflammatory agents and adjuvant analgesics; (iii) outline novel targets for
development of analgesic drugs. The course will also help students prepare for the exams in Pharmacology 2 and 3.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
After the last lecture of the course, a written test is taken in the instruction period to obtain a mid-semester grade. Those who fail or do
not write this test have a second chance in the instruction period to improve in form of an oral conversation. Upon failing or missing
there is one more oral chance to obtain a mid-semester grade during the first two weeks of the exam period.
Making up for missed classes
There is no way to make up for missed lectures.
Reading material
- Obligatory literature
None.
- Literature developed by the Department
The material of the lectures is available in PDF format in the Neptun.
- Notes
None.
- Recommended literature
None.
Lectures
1 Basic terms related to pain and nociceptors
Dr. Pethő Gábor
2 Features of capsaicin-sensitive nociceptors
Dr. Pethő Gábor
3 Peripheral mechanisms of hyperalgesia
Dr. Pethő Gábor
4 Central mechanisms of hyperalgesia and allodynia
Dr. Pethő Gábor
5 Features of neuropathic pain
Dr. Pethő Gábor
6 Pharmacology of opioid analgesics I
Dr. Pethő Gábor
7 Pharmacology of opioid analgesics II
Dr. Pethő Gábor
8 Pharmacology of non-steroidal antiinflammatory analgesic drugs II
Dr. Pethő Gábor
9 Pharmacology of non-steroidal antiinflammatory analgesic drugs II
Dr. Pethő Gábor
10 Adjuvant analgesics
Dr. Pethő Gábor
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11 New targets for development of analgesics I
Dr. Pethő Gábor
12 New targets for development of analgesics II
Dr. Pethő Gábor
Practices
Seminars
Exam topics/questions
No exam questions are given. The essay questions of the written exam are based on the material presented.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPE-MGT-T PHARMACEUTICAL TECHNOLOGY OF MODIFIED DRUG RELEASE
Course director: DR. SZILÁRD PÁL, assistant professor
Institute of Pharmaceutical Technology and Biopharmacy
1 credit ▪ midsemester grade ▪ Elective subject for the Pharmaceutical module ▪ spring semester ▪ recommended semester: 8
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPG-GT4 parallel
Topic
Students can get acquainted in details with modified drug delivery technologies and special industrial drug manufacture (3D printing,
manufacture of multi-layer tablets and osmotic preparations) and the importance of pharmaceutical excipients. Student will learn special
manufacturing technologies through the demonstration of dosage forms already available in the pharmaceutical therapy.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
During the end semester test 60 % should be reached.
Making up for missed classes
According to the Code of Studies and Examinations
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
James Swarbrick: Encyclopedia of Pharmaceutical Technology, Informa Healthcare, 2011
Lectures
1 Theory of modified drug release
Dr. Pál Szilárd
2 Importance of excipients, patents of excipient-compositions
Dr. Kása Péter
3 Immediate drug-release (OraSolv, DuraSolv, Zydis technology)
Dr. Pál Szilárd
4 Sustained drug-release: Multiparticulate dosage forms I. (sustained release pellets in practice)
Dr. Pál Szilárd
5 Multiparticulate dosage forms II. (MUPS technology)
Dr. Pál Szilárd
6 Matrix systems I. (hydrophilic matrices)
Dr. Pál Szilárd
7 Matrix systems II. (hydrophobic matrices)
Dr. Pál Szilárd
8 Osmotic technology (EOP, OROS, L-OROS, GITS)
Dr. Pál Szilárd
9 Geometry based drug-release (Geomatrix, Procise, Smartrix technology)
Dr. Kása Péter
10 Chronotherapeutic systems (Geoclock technology)
Dr. Pál Szilárd
11 Parenterally administered modified drug delivery
Dr. Pál Szilárd
12 Site specific drug release (gastroretentive systems, colon-specific drug delivery)
Dr. Pál Szilárd
13 Halving of tablets, technology of halving-friendly tablets, concept of ,,ghost” tablets
Dr. Kása Péter
14 End-year test
Dr. Pál Szilárd
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Practices
Seminars
Exam topics/questions
http://gytk.pte.hu
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Kása Péter (ISWPRM), Dr. Pál Szilárd (PASMAAO.PTE)
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OPF-GTH-T GENE THERAPY
Course director: DR. GÉZA SÁFRÁNY, visiting professor
Institute of Laboratory Medicine
1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 8
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 3 – 30 Prerequisites: none
Topic
We wish to give a short overview about the present state of gene therapy, the current ongoing clinical trials and the potential side effects
of gene therapy and about the ethical considerations. The various viral and non-viral gene delivery protocols suitable for high efficiency
gene delivery both under in vitro and in vivo conditions will be discussed in details. Gene therapy protocols applied in the treatment of
malignant diseases will be presented together with the results of ongoing clinical trials. We will talk about the results and the potentials
of the treatments of inherited genetic disorders. One of the most promising field of the current clinical trials is the treatment of ischemic
diseases, the results will be presented. The potential applications of stem cells during gene therapy will be described, as well. Finally, we
will discuss the side effects occurring during gene therapy and the ethical considerations will also be mentioned.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Test
Making up for missed classes
Joining later lectures, individual consultations.
Reading material
- Obligatory literature
1. Kelly K. Hunt, Stephan A. Vorburger and Stephen G. Swisher (ed.): Gene Therapy for Cancer, 2007 Humana Press Inc. 999
Riverview Drive, Suite 208 Totowa, New Jersey 07512
2. Thomas F. Kresina (ed.): Introduction to Molecular Medicine and Gene Therapy, 2001 by Wiley-Liss, Inc. ISBNs: 0-471-39188-
3 (Hardback); 0-471-22387-5 (Electronic)
- Literature developed by the Department
1. Sáfrány G.: A génterápia génsebészeti alapjai és jelenlegi helyzete, A Genom (ed.: Hídvégi EJ), Budapest, Széphalom
Könyvműhely 2003, pp 187-204
2. Sáfrány G.: A vasculáris génterápia és a csontvelőőssejt-terápia, Atherosclerosis (ed.: Császár A.), Budapest, Synergo Kiadó,
2004 pp 336-344
- Notes
- Recommended literature
http://www.genetherapynet.com/clinicaltrialsgov.html
http://www.bioportfolio.com/cgi-bin/acatalog/Human_Gene_Therapy_Course.html
http://openlearn.open.ac.uk/course/view.php?id=2430
Lectures
1 Introduction to gene therapy, ongoing clinical trials
Dr. Sáfrány Géza
2 Gene delivery protocols, viral vectors applied in gene therapy
Dr. Sáfrány Géza
3 Targeted gene delivery and targeted gene expression
Dr. Miseta Attila
4 Gene therapy of HIV
Dr. Sáfrány Géza
5 Application of dendritic cells in gene therapy
Dr. Sáfrány Géza
6 Gene directed enzyme pro-drug therapy of malignant diseases
Dr. Sáfrány Géza
7 Immune therapy of malignant diseases
Dr. Sáfrány Géza
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8 Radiation-driven gene therapy of malignant disease
Dr. Sáfrány Géza
9 Stem cells in gene therapy
Dr. Sáfrány Géza
10 Treatment of immune-deficiencies with gene therapy
Dr. Sáfrány Géza
11 Gene therapy of ischemic diseases
Dr. Sáfrány Géza
12 Gene therapy of cystic fibrosis
Dr. Miseta Attila
13 Gene therapy of thalassemia
Dr. Sáfrány Géza
14 Oncolytic viruses in tumor therapy
Dr. Sáfrány Géza
Practices
Seminars
Exam topics/questions
Multiple choice tests for checking the acquisition of course material is given at the end of semester. Questions include material discussed
in lectures and seminars.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPF-IVF-T INFECTIONS AND IMMUNITY
Course director: DR. JÚLIA BARTHÓ-SZEKERES, professor
Department of Medical Biology
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 8
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 2 – 25 Prerequisites: OPO-IMM completed + OPO-MI1 completed
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The importance of anti-infectious immunity is not restricted to elimination of pathogens, but is also responsible for long lasting protection,
as well as -in some cases- immunopathological disorders
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
Continuous
Making up for missed classes
Consultation
Reading material
- Obligatory literature
- Literature developed by the Department
Lecture slides
- Notes
- Recommended literature
1. H. Chapel, M. Haeney, N. Misbah, Snowden: Clinical Immunology, Blackwell, 2008
2. S. Kartikeyan, R.N. Bharmal, R.P. Tiwari, and P.S. Bisen: HIV and AIDS: Basic Elements and Priorities, 2007
3. T. Platts-Mills and Johannes Ring: Allergy in Practice, 2003
Lectures
1 Non-specific defence. Surface barriers, normal colonizing flora, phagocytosis, complement system.
Dr. Barthóné Dr. Szekeres Júlia
2 Non-specific defence. Surface barriers, normal colonizing flora, phagocytosis, complement system.
Dr. Barthóné Dr. Szekeres Júlia
3 Antigen presentation and recognition. Dendritic cells, pattern recognition receptors.
Dr. Barthóné Dr. Szekeres Júlia
4 Antigen presentation and recognition. Dendritic cells, pattern recognition receptors.
Dr. Barthóné Dr. Szekeres Júlia
5 Defence against extracellular microorganisms. The role of immunoglobulin classes. Mucosal immunity.
Dr. Barthóné Dr. Szekeres Júlia
6 Defence against extracellular microorganisms. The role of immunoglobulin classes. Mucosal immunity.
Dr. Barthóné Dr. Szekeres Júlia
7 Defence against intracellular microorganisms. Defence against viral infections. Viruses and immunosuppression.
Dr. Barthóné Dr. Szekeres Júlia
8 Defence against intracellular microorganisms. Defence against viral infections. Viruses and immunosuppression.
Dr. Barthóné Dr. Szekeres Júlia
9 Defence against parasitic infections. Micro-and macroparasite infections that polarize the immune response.
Dr. Barthóné Dr. Szekeres Júlia
10 Defence against parasitic infections. Micro-and macroparasite infections that polarize the immune response.
Dr. Barthóné Dr. Szekeres Júlia
11 Evasion and use of the innate and adaptive immune responses by microorganisms.
Dr. Barthóné Dr. Szekeres Júlia
12 Evasion and use of the innate and adaptive immune responses by microorganisms.
Dr. Barthóné Dr. Szekeres Júlia
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13 Healing of infectious diseases. The pathogenic role of anti-infectious immunity; local inflammation, systemic inflammation,
sepsis, endotoxin shock, toxic shock syndrome.
Dr. Barthóné Dr. Szekeres Júlia
14 Healing of infectious diseases. The pathogenic role of anti-infectious immunity; local inflammation, systemic inflammation,
sepsis, endotoxin shock, toxic shock syndrome.
Dr. Barthóné Dr. Szekeres Júlia
15 The pathogenic role of anti-infectious immunity; hypersensitivity reactions in bacterial-parasitic and fungal infections.
Dr. Barthóné Dr. Szekeres Júlia
16 The pathogenic role of anti-infectious immunity; hypersensitivity reactions in bacterial-parasitic and fungal infections.
Dr. Barthóné Dr. Szekeres Júlia
17 Induction of autoimmunity; molecular mimicri, epitope spreading, polyclonal T or B cell activation.
Dr. Barthóné Dr. Szekeres Júlia
18 Induction of autoimmunity; molecular mimicri, epitope spreading, polyclonal T or B cell activation.
Dr. Barthóné Dr. Szekeres Júlia
19 Immunopathological alterations following viral infections. The involvement of CD8+ T cells.
Dr. Barthóné Dr. Szekeres Júlia
20 Immunopathological alterations following viral infections. The involvement of CD8+ T cells.
Dr. Barthóné Dr. Szekeres Júlia
21 Immunopathological alterations following viral infections. The involvement of CD4+ T cells.
Dr. Barthóné Dr. Szekeres Júlia
22 Immunopathological alterations following viral infections. The involvement of CD4+ T cells.
Dr. Barthóné Dr. Szekeres Júlia
23 Immunopathological alterations following viral infections. The involvement of antibodies.
Dr. Barthóné Dr. Szekeres Júlia
24 Immunopathological alterations following viral infections. The involvement of antibodies
Dr. Barthóné Dr. Szekeres Júlia
25 Vaccination; Type of vaccines, requirements for vaccines.
Dr. Barthóné Dr. Szekeres Júlia
26 Vaccination; Type of vaccines, requirements for vaccines.
Dr. Barthóné Dr. Szekeres Júlia
27 Vaccination; rational vaccine development, mandatory vaccines.
Dr. Barthóné Dr. Szekeres Júlia
28 Vaccination; rational vaccine development, mandatory vaccines.
Dr. Barthóné Dr. Szekeres Júlia
Practices
Seminars
Exam topics/questions
The same as lecture topics
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
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OPE-GSI-T PHARMACEUTICAL INFORMATICS
Course director: DR. LAJOS BOTZ, professor
Department of Pharmaceutics and University Pharmacy
2 credit ▪ midsemester grade ▪ Elective subject for the Pharmaceutical module ▪ autumn semester ▪ recommended semester: 9
Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPG-GI3-T completed
Topic
Students will become familiar with pharmaceutical databases, IT communication systems and drug management software applications.
Pharmaceutical IT methods such as telemedicine, or Internet pharmacies will be also covered in lectures. Lectures will give students
insight into ethical and legal aspects of information sources, and their critical evaluation. The aim of the lectures is to consolidate the
pharmaceutical IT skills of students. Students will be equipped with up-to-date pharmaceutical IT skills: use of databases and Internet
information sources.
During the semester the students will become familiar with the basics of personal computer and network systems is general and with the
specifications of pharmaceutical informatics, such as the development and stages of pharmacy informatics, principles of pharmacy
softwares. Also the different software types and drug dispensing rules used in pharmacies are introduced in this semester. The basic
knowledge of drug interactions and the available techniques and databases for screening interactions in everyday practice is also an
emphasized topic. After acquiring the principles of informatics and pharmaceutical informatics the students will be able to synthesize the
elements and understand the functions of pharmacy information management systems. Even the possibilities and threats of online drug
marketing and the capability of finding relevant and authentic pharmaceutical information on the web is the objective of this course.
Conditions for acceptance of the semester
Acceptance of term/semester (requirements of registration for the exam):
- Regular attendance of classes/lectures (maximum 25 % of absence is accepted),
- Assignments given in class should be carried out during term-time and,
- The mid-term and end-of-the-term test(s) should be passed (60,1%, minimum grade 2).
End-of-semester grade is given by end-of-the-term test’s result, any tests written throughout the semester and student performance during
the semester.
Examination and granting of grades: for Pharmaceutical Informatics grade (midterm grade) is given based on mid-term and end-of-the-
term test results.
Mid-term exams
Retake opportunity is possible following personal discussion.
Making up for missed classes
Retake opportunity is possible following personal discussion.
Reading material
- Obligatory literature
- Literature developed by the Department
List of study aids to acquire curriculum (books, notes, other) and all presentations can be downloaded from Neptun Meet Street.
- Notes
- Recommended literature
Ed. R. Fisher: Information Technology for Pharmacists, Pharmaceutical Press
Brent I. Fox, Margaret R. Thrower, Bill G. Felkey: Building Core Competencies in Pharmacy Informatics, American Pharmacists
Association, 2010
Lectures
1 Personal computer and network system fundamentals 1.
Dr. Vida Róbert György
2 Personal computer and network system fundamentals 2.
Dr. Vida Róbert György
3 Database systems, IT and search engines 1.
Dr. Vida Róbert György
4 Database systems, IT and search engines 2.
Dr. Vida Róbert György
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5 Drug interactions, Drug interaction databases 1.
Dr. Végh Anna
6 Drug interactions, Drug interaction databases 2.
Dr. Végh Anna
7 Drug interactions, Drug interaction databases 3.
Dr. Végh Anna
8 Drug interactions, Drug interaction databases 4.
Dr. Végh Anna
9 Pharmaceutical Information Management Systems 1.
Dr. Fittler András Tamás
10 Pharmaceutical Information Management Systems 2.
Dr. Fittler András Tamás
11 Pharmaceutical Information Management Systems 3.
Dr. Fittler András Tamás
12 Pharmaceutical Information Management Systems 4.
Dr. Fittler András Tamás
Practices
1 Evidence Based Medicine - Critical Appraisal.
2 Evidence Based Medicine: Outcome Measures.
3 Evidence Based Medicine: Calculations.
4 Evidence Based Medicine: Interpretation of results. Practice
5 Kaposi Mór Oktató Kórház visit
6 Kaposi Mór Oktató Kórház visit
7 Kaposi Mór Oktató Kórház visit
8 Kaposi Mór Oktató Kórház visit
9 Retail Pharmacy software: features and structure of professional pharmaceutical systems.
10 Pharmaceutical software for the follow-up of work procedures (compounding, drug manufacturing).
11 Application of professional pharmaceutical software interfaces for the improvement of medication of patients (filtering of
endangered patient groups and drug interactions).
12 Pharmacy software for the follow-up of work procedures: (management, accounting of prescriptions).
Seminars
Exam topics/questions
Based on the topics of the lectures and seminars.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
Dr. Botz Lajos (BOLFAAP.PTE), Dr. Fittler András Tamás (FIAQAAK.PTE), Dr. Végh Anna (VEAOABO.PTE), Dr. Vida Róbert
György (VIRNAAO.PTE)
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OPE-GST-T SPECIAL FIELDS OF PHARMACOLOGY
Course director: DR. GÁBOR PETHŐ, professor
Department of Pharmacology and Pharmacotherapy
1 credit ▪ midsemester grade ▪ Elective subject for the Pharmaceutical module ▪ autumn semester ▪ recommended semester: 9
Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours
Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPG-GH1 completed
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The aim of the course is to present those fields of pharmacology that are not covered at all or only partially discussed in the compulsory
courses Pharmacology 1-2-3 because of time limits. These are the following: use of drugs during pregnancy and lactation; significance
of pharmacogenomics in therapy and drug development, pharmacology of retinoids; other drugs used in dermatology; special aspects of
drugs used in urology; use of meta-analysis in evaluation of drugs, clinical significance of basic pharmacodynamic and pharmacokinetic
parameters; special aspects of drugs used by inhalation, basics of chronopharmacology; pharmacology of contrast media, drugs and
chirality. The course wishes to contribute to a better understanding of the use of drugs in the clinical practice and may help students
prepare for the pharmacology exams.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
After the last lecture of the course, a written test is taken in the instruction period to obtain a mid-semester grade. Those who fail or do
not write this test have a second chance in the instruction period to improve in form of an oral conversation. Upon failing or missing
there is one more oral chance to obtain a mid-semester grade during the first two weeks of the exam period.
Making up for missed classes
There is no way to make up for missed lectures.
Reading material
- Obligatory literature
None.
- Literature developed by the Department
The material of the lectures is available in PDF format in the Neptun.
- Notes
None.
- Recommended literature
None.
Lectures
1 Special aspects of use of drugs during pregnancy and lactation
Dr. Pethő Gábor
2 Significance of pharmacogenomics in therapy and drug development
Dr. Pethő Gábor
3 Use of meta-analysis in evaluation of drugs
Dr. Pethő Gábor
4 Drugs and chirality
Dr. Pethő Gábor
5 Clinical significance of pharmacodynamic and pharmacokinetic parameters on the example of drugs used in respiratory diseases I
Dr. Pethő Gábor
6 Clinical significance of pharmacodynamic and pharmacokinetic parameters on the example of drugs used in respiratory diseases II
Dr. Pethő Gábor
7 Pharmacology of retinoids
Dr. Pethő Gábor
8 Drugs (other than retinoids) used in dermatology
Dr. Pethő Gábor
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
207
9 Urological pharmacology I
Dr. Pethő Gábor
10 Urological pharmacology II
Dr. Pethő Gábor
11 Pharmacology of contrast media
Dr. Pethő Gábor
12 Basics of chronopharmacology
Dr. Pethő Gábor
Practices
Seminars
Exam topics/questions
No exam questions are given. The essay questions of the written exam are based on the material presented.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
208
OPF-SUO-T EMERGENCY MEDICINE
Course director: DR. ZSÓFIA VERZÁR, associate professor
Department of Emergency Medicine
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 9
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 150 Prerequisites: OPO-KL1 completed
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
It is a basic requirement to initialize the aspect of proper emergency care for those who do not take part in emergency medicine. The aim
is getting closer to the purpose of care, decrease of avoidable death rates, prevention of organ failure, avoidance of disability, relief of
suffering and pain.
Conditions for acceptance of the semester
Test exam.
Mid-term exams
-
Making up for missed classes
Personal communication with the tutors.
Reading material
- Obligatory literature
R. Aghababian: Essentials of Emergency Medicine, 2nd edition
- Literature developed by the Department
- Notes
- Recommended literature
Lectures
1 Patient examination according to ABCDE
Dr. Gaál Ildikó
2 Resuscitacion
BLS, ALS, EPLS
Dr. Gaál Ildikó
3 Cardiovascular diseases
Dr. Verzár Zsófia
4 Cardiovascular diseases
Dr. Verzár Zsófia
5 Differential diagnosis of limb pain
Dr. Bóna Ernő
6 Pediatric emergency care
Dr. Bóna Ernő
7 Toxicology
Environmental diseases
Dr. Varga Szilárd
8 Toxicology
Environmental diseases
Dr. Varga Szilárd
9 Emergency care in neurology
Dr. Bóna Ernő
10 Acut psychiatric disorders
Dr. Bóna Ernő
11 Trauma care (ETC), Burns
Dr. Gaál Ildikó
12 Trauma care (ETC), Burns
Dr. Gaál Ildikó
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019
209
13 Acute abdomen, Abdominal pain
Dr. Verzár Zsófia
14 Acute abdomen, Abdominal pain
Dr. Verzár Zsófia
Practices
Seminars
Exam topics/questions
Website of Emergency Medicine, University of Pécs.
Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject
Participants