substituted benzamides for synthesis of ...general procedure for the preparation of compounds 1. r 1...

S1

Supporting Information

Visible-Light-Induced Intramolecular sp3 C−H Oxidation of o-alkyl

Substituted Benzamides for Synthesis of IminoisobenzofuransLingang Wu, † Yanan Hao, † Yuxiu Liu, † and Qingmin Wang *,†,‡

†State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, People’s Republic of China

‡Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071,

People’s Republic of China

Table of Contents

1. Unsuccessful substrates (S2)

2. General procedure for the synthesis of substrate (S2-S8)

3. General procedure for the synthesis of products (S8-S14)

4. NMR spectra (S15-S58)

5. The X-ray crystallographic analysis data (S59-S67)

6. Analytical data of HRMS (S67-S70)

Electronic Supplementary Material (ESI) for ChemComm.This journal is © The Royal Society of Chemistry 2019

S2

Unsuccessful substrates

O

NHBn

O

NH

CF3 O

NHPh

General procedure for the preparation of compounds 1.

R1NH2EDCI, DMAP

DCM, rt

O

OH

R3

R2R4

O

NHR1

R3

R2R4

A mixture of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (1.04g,

6.5 mmol, 1.3 equiv), DMAP (0.92g, 7.5 mmol, 1.5 equiv), acid (5 mmol, 1.0 equiv),

and amine (5 mmol, 1.0 equiv) in CH2Cl2 (20 mL) was stirred at room temperature for

6 h. After completing reaction, the mixture was added 30 mL H2O. The organic layer

was separated and the aqueous layer was extracted with dichloromethane (20mL × 3).

The combined organic phase was washed with brine (20 mL), and then dried over

Na2SO4. After filtration, the solvent was concentrated in vacuo. The products were

purified by column chromatography with petroleum ether and ethyl acetate as an

eluent.

2-isopropyl-N-phenylbenzamide (1a)

White solid. M.p. =132-134 °C. 1H NMR (400 MHz, CDCl3) δ 7.62

(d, J = 7.8 Hz, 2H), 7.49 (s, 1H), 7.47 – 7.33 (m, 5H), 7.28 – 7.21 (m,

1H), 7.19– 7.12(m, 1H), 3.48 – 3.35 (m, 1H), 1.28 (d, J = 6.9 Hz,

6H). 13C NMR (100 MHz, CDCl3) δ 168.5, 146.9, 138.0, 136.1, 130.4, 129.1, 126.4,

125.8, 124.6, 119.8, 30.0, 24.2. HRMS (ESI): calcd. for C16H18NO [M + H]+ 240.1383;

found 240.1381. (Petroleum ether/EtOAc, 5/1).

N-(4-bromophenyl)-2-isopropylbenzamide (1b)

White solid. M.p. =180-182 °C. 1H NMR (400 MHz, CDCl3)

δ 7.64 – 7.39 (m, 7H), 7.32 – 7.22 (m, 1H), 3.53 – 3.14 (m,

1H), 1.30 (d, J = 6.9 Hz, 6H). 13C NMR (100 MHz, CDCl3) δ

168.5, 147.0, 137.1), 135.8, 132.1, 130.6, 126.4, 126.3,

125.8, 121.3, 117.1, 30.0, 24.1. HRMS (ESI): calcd. for C16H17BrNO [M + H]+

O

NHPh

1a

O

NH

1b

Br

S3

318.0488; found 318.0484. (Petroleum ether/EtOAc, 5/1).

N-(4-chlorophenyl)-2-isopropylbenzamide (1c)


δ 7.58 (t, J = 11.8 Hz, 3H), 7.47 – 7.35 (m, 3H), 7.31 (d, J =

8.4 Hz, 2H), 7.27 – 7.19 (m, 1H), 3.64 – 3.14 (m, 1H), 1.27 (d,

J = 6.8 Hz, 6H). 13C NMR (100 MHz, CDCl3) δ 168.5, 147.0,

136.6, 135.8, 130.6, 129.5, 129.1, 126.4, 126.3, 125.9, 121.0, 30.0, 24.1. HRMS (ESI):

calcd. for C16H17ClNO [M + H]+ 274.0993; found 274.0990. (Petroleum ether/EtOAc,

5/1).

N-(4-(tert-butyl)phenyl)-2-isopropylbenzamide (1d)

White solid. M.p. =148-150 °C. 1H NMR (400 MHz, CDCl3) δ

7.68 – 7.55(m, 2H), 7.53 – 7.39 (m, 6H), 7.32 – 7.22 (m, 1H),

3.60 – 3.21 (m, 1H), 1.36 (s, 9H), 1.31 (d, J = 6.9 Hz, 6H). 13C

NMR (100 MHz, CDCl3) δ 168.4, 147.6, 146.9, 136.2, 135.4,

130.3, 126.3, 126.3, 125.9, 125.8, 119.6, 34.4, 31.4, 30.0, 24.2. HRMS (ESI): calcd.

for C20H26NO [M + H]+ 296.2009; found 296.2005. (Petroleum ether/EtOAc, 5/1).

2-isopropyl-N-(p-tolyl)benzamide (1e)

White solid. M.p. =139-141 °C. 1H NMR (400 MHz,

CDCl3) δ 7.54 – 7.35 (m, 6H), 7.28 – 7.19 (m, 1H), 7.16

(d, J = 8.2 Hz, 2H), 3.48 – 3.31 (m, 1H), 2.34 (s, 3H),

1.27 (d, J = 6.9 Hz, 6H). 13C NMR (100 MHz, CDCl3) δ

168.4, 146.9, 136.2, 135.4, 134.2, 130.3, 129.6, 126.4, 126.3, 125.8, 119.8, 30.0, 24.2,

20.9. HRMS (ESI): calcd. for C17H20NO [M + H]+ 254.1539; found 254.1536.

(Petroleum ether/EtOAc, 5/1).

N-([1,1'-biphenyl]-4-yl)-2-isopropylbenzamide (1f)


δ 7.74 (d, J = 8.1 Hz, 2H), 7.67 – 7.56 (m, 5H), 7.57 – 7.43

(m, 5H), 7.42 – 7.35 (m, 1H), 7.34-7.24 (m, 1H), 3.60 – 3.34

(m, 6.4 Hz, 1H), 1.34 (d, J = 6.7 Hz, 6H). 13C NMR (100

MHz, CDCl3) δ 168.5, 147.0, 140.5, 137.5, 137.3, 136.1, 130.5, 128.8, 127.7, 127.2,

O

NH

1c

Cl

O

NH

1d

tBu

O

NH

1e

Me

O

NH

1f

Ph

S4

126.9, 126.4, 125.8, 120.1, 30.0, 24.2. HRMS (ESI): calcd. for C22H22NO [M + H]+


2-isopropyl-N-(m-tolyl)benzamide (1g)


δ 7.65 – 7.55 (m, 2H), 7.50 – 7.35 (m, 4H), 7.30 – 7.24 (m,

2H), 7.01 (d, J = 7.5 Hz, 1H), 3.77 – 3.10 (m, 1H), 2.40 (s,

3H), 1.31 (d, J = 6.9 Hz, 6H). 13C NMR (100 MHz, CDCl3) δ 168.5, 146.9, 139.1,

137.9, 136.2, 130.3, 128.9, 126.3, 126.3, 125.8, 125.3, 120.4, 116.8, 30.0, 24.2, 21.5.

HRMS (ESI): calcd. for C17H20NO [M + H]+ 254.1539; found 254.1536. (Petroleum

ether/EtOAc, 5/1).

2-isopropyl-N-(o-tolyl)benzamide (1h)


8.05 (d, J = 7.9 Hz, 1H), 7.55 – 7.40 (m, 3H), 7.39 – 7.19 (m,

4H), 7.20 – 7.08 (m, 1H), 3.57 – 3.42 (m, 1H), 2.33 (s, 3H), 1.33

(d, J = 6.8 Hz, 6H). 13C NMR (100 MHz, CDCl3) δ 168.5, 146.9,

130.6, 130.4, 128.9, 126.9, 126.4, 126.4, 125.8, 125.4, 122.9, 30.0, 24.2, 17.9. HRMS

(ESI): calcd. for C17H20NO [M + H]+ 254.1539; found 254.1535. (Petroleum

ether/EtOAc, 5/1).

N-(3,4-dichlorophenyl)-2-isopropylbenzamide (1i)


δ 7.89 (s, 1H), 7.68 – 7.56 (m, 1H), 7.48 – 7.33 (m, 5H), 7.25

– 7.13 (m, 1H), 3.43 – 3.26 (m, 1H), 1.27 (d, J = 6.7 Hz, 6H).

13C NMR (100 MHz, CDCl3) δ 168.5, 147.1, 137.4, 135.3,

132.9, 130.8, 130.5, 127.7, 126.5, 126.2, 125.8, 121.5, 119.0, 30.0, 24.1. HRMS (ESI):

calcd. for C16H16Cl2NO [M + H]+ 308.0603; found 308.0600. (Petroleum ether/EtOAc,

5/1).

2-isopropyl-N-(naphthalen-2-yl)benzamide (1j)


δ 8.37 (s, 1H), 7.88 – 7.76 (m, 3H), 7.65 (s, 1H), 7.53 – 7.38

(m, 6H), 7.30 – 7.21 (m, 1H), 3.52 – 3.40 (m, 1H), 1.31 (d, J

O

NH

1g

Me

O

NH

1h

Me

O

NH

1i

Cl

Cl

O

NH

1j

S5

= 6.8 Hz, 6H). 13C NMR (100 MHz, CDCl3) δ 168.6, 147.1, 136.1, 135.4, 133.9,

130.7, 130.5, 128.9, 127.7, 127.6, 126.6, 126.4, 125.8, 125.1, 119.7, 116.6, 30.1, 24.2.


ether/EtOAc, 5/1).

2-isopropyl-N-methoxybenzamide (1k)


(s, 1H), 7.30 – 7.20 (m, 2H), 7.12 – 6.96 (m, 2H), 3.70 (s, 3H), 3.25

– 2.96 (m, 1H), 1.11 (d, J = 6.9 Hz, 6H). 13C NMR (100 MHz,

CDCl3) δ 168.1, 147.5, 132.1, 130.6, 127.0, 126.1, 125.5, 64.4, 29.9, 24.0. HRMS

(ESI): calcd. for C11H16NO2 [M + H]+ 194.1176; found 194.1172. (Petroleum

ether/EtOAc, 3/1).

2-cyclohexyl-N-phenylbenzamide (1l)


(d, J = 7.9 Hz, 2H), 7.53 (s, 1H), 7.44 – 7.30 (m, 5H), 7.26 – 7.13

(m, 2H), 3.08 – 2.92 (m, 1H), 1.98 – 1.65 (m, 5H), 1.51 – 1.20 (m,

5H). 13C NMR (100 MHz, CDCl3) δ 168.4, 145.9, 138.0, 136.3,

130.2, 129.1, 127.0, 126.5, 125.8, 124.5, 119.9, 40.5, 34.6, 26.7, 26.1. HRMS (ESI):

calcd. for C19H22NO [M + H]+ 280.1696; found 280.1691. (Petroleum ether/EtOAc,

5/1).

2-cyclopentyl-N-phenylbenzamide (1m)


(s, 1H), 7.59 (d, J = 7.8 Hz, 2H), 7.41 – 7.30 (m, 5H), 7.23 – 7.10

(m, 2H), 3.46 – 3.34 (m, 1H), 2.16 – 2.00 (m, 2H), 1.81 – 1.73 (m,

2H), 1.71 – 1.54 (m, 4H). 13C NMR (100 MHz, CDCl3) δ 168.7,

144.7, 138.0, 136.9, 130.3, 129.1, 126.9, 126.4, 125.7, 124.5, 119.8,

41.9, 35.3, 25.9. HRMS (ESI): calcd. for C18H20NO [M + H]+ 266.1539; found

266.1535. (Petroleum ether/EtOAc, 5/1).

tert-butyl-4-(2-(phenylcarbamoyl)phenyl)piperidine-1-

carboxylate (1n)


O

NHOMe

1k

O

NHPh

1l

O

NHPh

1m

O

NHPh

1n

NBoc

S6

7.66 – 7.51 (m, 3H), 7.48 – 7.30 (m, 5H), 7.29 – 7.22 (m, 1H), 7.19 – 7.11 (m, 1H),

4.24 – 4.08 (m, 2H), 3.26 – 3.12 (m, 1H), 2.83 – 2.64 (m, 2H), 1.89 – 1.81 (m, 2H),

1.64 – 1.57 (m, 2H), 1.45 (s, 9H). 13C NMR (100 MHz, CDCl3) δ 168.0, 154.8, 144.3,

137.9, 136.2, 130.6, 129.2, 127.1, 126.6, 126.3, 124.7, 119.9, 79.4, 38.5, 33.3, 28.4.

HRMS (ESI): calcd. for C23H39N2O3 [M + H]+ 381.2173; found 381.2175. (Petroleum

ether/EtOAc, 5/1).

5-bromo-2-isopropyl-N-phenylbenzamide (1o)


7.72 – 7.50 (m, 5H), 7.44 – 7.35 (m, 2H), 7.33 – 7.28 (m, 1H),

7.23 – 7.16 (m, 1H), 3.42 – 3.30 (m, 1H), 1.28 (d, J = 6.6 Hz,

6H). 13C NMR (100 MHz, CDCl3) δ 166.7, 145.9, 137.8, 137.6,

133.3, 129.2, 129.1, 128.3, 124.8, 119.9, 119.2, 29.8, 24.0. HRMS (ESI): calcd. for

C16H17BrNO [M + H]+ 318.0488; found 318.0484. (Petroleum ether/EtOAc, 5/1).

2-cyclohexyl-5-fluoro-N-phenylbenzamide (1p)


7.81 – 7.63 (m, 1H), 7.58 – 7.38 (m, 2H), 7.27 – 7.14 (m, 3H),

7.08 – 6.86 (m, 3H), 2.92 – 2.74 (m, 1H), 1.87 – 1.49 (m, 5H),

1.42 – 0.92 (m, 5H). 13C NMR (100 MHz, CDCl3) δ 167.2,

160.30 (d, J = 246.3 Hz), 141.5, 137.7, 137.55 (d, J = 5.9 Hz),

129.1, 128.72 (d, J = 7.4 Hz), 124.7, 120.1, 117.03 (d, J = 20.5 Hz), 113.50 (d, J =

22.4 Hz), 40.0, 34.7, 26.7, 26.0. HRMS (ESI): calcd. for C19H21FNO [M + H]+


5-bromo-2-cyclohexyl-N-phenylbenzamide (1q)


7.55 – 7.34 (m, 5H), 7.27 – 7.18 (m, 2H), 7.15 – 7.10 (m, 1H),

7.06 – 6.98 (m, 1H), 2.86 – 2.75 (m, 1H), 1.79 – 1.52 (m, 5H),

1.33 – 0.98 (m, 5H). 13C NMR (100 MHz, CDCl3) δ 166.7,

145.0, 138.0, 137.6, 133.2, 129.3, 129.2, 128.9, 124.8, 120.0, 119.1, 40.2, 34.4, 26.6,

26.0. HRMS (ESI): calcd. for C19H21BrNO [M + H]+ 358.0801; found 358.0797.

O

NHPh

1o

Br

O

NHPh

1p

F

O

NHPh

1q

Br

S7

2-cyclohexyl-5-methyl-N-phenylbenzamide (1r)


7.72 – 7.57 (m, 2H), 7.47 (s, 1H), 7.40 – 7.32 (m, 2H), 7.30 –

7.20 (m, 3H), 7.15 (t, J = 7.4 Hz, 1H), 3.01 – 2.90 (m, 1H), 2.34

(s, 3H), 1.92 – 1.59 (m, 5H), 1.51 – 1.10 (m, 5H). 13C NMR

(100 MHz, CDCl3) δ 168.5, 142.9, 138.0, 136.2, 135.4, 131.0, 129.1, 127.1, 126.9,

124.5, 119.8, 40.1, 34.7, 26.8, 26.1, 20.8. HRMS (ESI): calcd. for C20H24NO [M +

H]+ 294.1852; found 294.1850. (Petroleum ether/EtOAc, 5/1).

5-chloro-2-cyclohexyl-N-phenylbenzamide (1s)


7.62 – 7.49 (m, 3H), 7.42 – 7.27 (m, 5H), 7.19 – 7.09 (m,

1H), 3.15 – 2.58 (m, 1H), 1.92 – 1.66 (m, 5H), 1.45 – 1.18

(m, 5H). 13C NMR (100 MHz, CDCl3) δ 166.9, 144.4, 137.7,

137.6, 131.3, 130.2, 129.2, 128.6, 126.5, 124.8, 120.0, 40.1, 34.5, 26.6, 26.0. HRMS

(ESI): calcd. for C19H21ClNO [M + H]+ 314.1306; found 314.1302. (Petroleum

ether/EtOAc, 5/1).

4-chloro-2-cyclohexyl-N-phenylbenzamide (1t)


δ 7.65 – 7.50 (m, 3H), 7.41 – 7.24 (m, 4H), 7.20 – 7.07 (m,

2H), 3.11 – 2.82 (m, 1H), 1.88 – 1.63 (m, 5H), 1.47 – 1.13 (m,

5H). 13C NMR (100 MHz, CDCl3) δ 167.5, 148.2, 137.8,

136.3, 134.5, 129.1, 128.0, 127.4, 125.9, 124.7, 120.0, 40.4, 34.4, 26.6, 26.0. HRMS

(ESI): calcd. for C19H21ClNO [M + H]+ 314.1306; found 314.1303. (Petroleum

ether/EtOAc, 5/1).

2-ethyl-N-phenylbenzamide (1u)

White solid. M.p. =141-143 °C. 1H NMR (400 MHz, CDCl3) δ 7.80 –

7.50 (m, 3H), 7.43 – 7.29 (m, 5H), 7.25 – 7.18 (m, 1H), 7.16 – 7.07

(m, 1H), 2.97 – 2.74 (m, 2H), 1.32 – 1.08 (m, 3H). 13C NMR (100

MHz, CDCl3) δ 168.3, 142.5, 138.0, 136.2, 130.3, 129.6, 129.1, 126.6, 125.9, 124.5,


O

NHPh

1r

Me

O

NHPh

1s

Cl

O

NHPh

1t

Cl

O

NHPh

1u

S8


2-methyl-N-phenylbenzamide (1v)


– 7.58 (m, 3H), 7.53 – 7.31 (m, 4H), 7.28 – 7.11 (m, 3H), 2.47 (s,

3H). 13C NMR (100 MHz, CDCl3) δ 168.3, 138.1, 136.4, 136.3,

131.2, 130.2, 129.0, 126.7, 125.8, 124.5, 120.0, 19.8. HRMS (ESI): calcd. for

C14H14NO [M + H]+ 212.1070; found 212.1073. (Petroleum ether/EtOAc, 5/1).

General experimental procedure for 2.

MeCN (2.5 mL), 48 hblue LED

O

N R1O

NHR1

R2R3 R

2

R3

Ru(bpy)3Cl26H2O (1.5 mol %)BI-OAc (1.5 equiv)

R4 R4

1 2

To a 10 mL glass vial was added 1 (0.25 mmol, 1.0 equiv), Ru(bpy)3Cl2•6H2O (2.8

mg, 0.00375 mmol, 1.5 mol %), BI-OAc (115 mg, 0.375 mmol, 1.5 equiv) and 2.5

mL of acetonitrile. The reaction mixture was degassed by bubbling with Ar for 15 s

with an outlet needle and the vial was sealed with PTFE cap. And the mixture was

stirred under the irradiation with blue LED for 48 h at room temperature. Upon

completion, the solvent was removed directly under reduced pressure to afford the

crude product, which was purified by flash column chromatography to afford the

desired product 2.

(Z)-3,3-dimethyl-N-phenylisobenzofuran-1(3H)-imine (2a)

White solid (48.0 mg, 81%). M.p. = 69-71 °C. 1H NMR (400

MHz, CDCl3) δ 7.93 (d, J = 7.6 Hz, 1H), 7.54 (td, J = 7.4, 0.9

Hz, 1H), 7.49 – 7.43 (m, 1H), 7.38 – 7.28 (m, 5H), 7.15 – 7.04

(m, 1H), 1.63 (s, 6H). 13C NMR (100 MHz, CDCl3) δ 157.8,

151.5, 146.8, 131.9, 130.2, 128.6, 128.5, 124.0, 123.8, 123.6, 120.2, 88.2, 27.8.


ether/EtOAc, 5/1).

(Z)-N-(4-bromophenyl)-3,3-dimethylisobenzofuran-

1(3H)-imine (2b)

White solid (61.2 mg, 82%). M.p. = 109-111 °C. 1H NMR

O

NHPh

1v

2a

O

N

2b

O

NBr

S9

(400 MHz, CDCl3) δ 7.90 (d, J = 7.6 Hz, 1H), 7.55 (td, J = 7.5, 1.0 Hz, 1H), 7.50 –

7.41 (m, 3H), 7.33 – 7.27 (m, 1H), 7.24 – 7.19 (m, 2H), 1.63 (s, 6H). 13C NMR (100

MHz, CDCl3) δ 158.3, 151.5, 145.8, 132.1, 131.5, 129.9, 128.7, 125.5, 124.0, 120.3,

116.7, 88.6, 27.8. HRMS (ESI): calcd. for C16H15BrNO [M + H]+ 316.0332; found


(Z)-N-(4-chlorophenyl)-3,3-dimethylisobenzofuran-1(3H)-

imine (2c)


(400 MHz, CDCl3) δ 7.91 (d, J = 7.6 Hz, 1H), 7.56 (td, J = 7.5,

1.0 Hz, 1H), 7.47 (td, J = 7.5, 0.9 Hz, 1H), 7.34 – 7.24 (m,

5H), 1.72 – 1.50 (m, 6H). 13C NMR (100 MHz, CDCl3) δ 158.3, 151.5, 145.3, 132.1,


C16H15ClNO [M + H]+ 272.0837; found 272.0834. (Petroleum ether/EtOAc, 5/1).

(Z)-N-(4-(tert-butyl)phenyl)-3,3-dimethylisobenzofuran-

1(3H)-imine (2d)


MHz, CDCl3) δ 7.97 (d, J = 7.6 Hz, 1H), 7.57 (td, J = 7.4, 1.1

Hz, 1H), 7.49 (td, J = 7.5, 0.9 Hz, 1H), 7.44 – 7.36 (m, 4H),

7.34 – 7.32 (m, 1H), 1.68 (s, 6H), 1.38 (s, 9H). 13C NMR (100 MHz, CDCl3) δ 157.4,

151.4, 146.6, 143.8, 131.7, 130.5, 128.6, 125.4, 124.0, 123.6, 120.2, 88.1, 34.4, 31.5,



(Z)-3,3-dimethyl-N-(p-tolyl)isobenzofuran-1(3H)-imine (2e)

Colourless oil (48.9 mg, 78%). 1H NMR (400 MHz, CDCl3) δ

7.92 (d, J = 7.6 Hz, 1H), 7.53 (td, J = 7.4, 1.0 Hz, 1H), 7.45

(td, J = 7.5, 0.8 Hz, 1H), 7.33 – 7.22 (m, 3H), 7.19 – 7.10 (m,

2H), 2.34 (s, 3H), 1.63 (s, 6H). 13C NMR (100 MHz, CDCl3) δ

157.6, 151.4, 144.1, 133.3, 131.8, 130.3, 129.2, 128.6, 123.9, 123.6, 120.2, 88.1, 27.9,



2c

O

NCl

2d

O

NtBu

2e

O

NMe

S10

(Z)-N-([1,1'-biphenyl]-4-yl)-3,3-dimethylisobenzofuran-

1(3H)-imine (2f)


(400 MHz, CDCl3) δ 7.95 (d, J = 7.6 Hz, 1H), 7.67 – 7.58

(m, 4H), 7.55 (dt, J = 7.5, 3.7 Hz, 1H), 7.48 (td, J = 7.5, 1.0

Hz, 1H), 7.45 – 7.39 (m, 4H), 7.35 – 7.29 (m, 2H), 1.66 (s, 6H). 13C NMR (100 MHz,

CDCl3) δ 158.0, 151.5, 146.0, 141.1, 136.6, 131.9, 130.2, 128.7, 127.2, 126.8, 126.7,



(Z)-3,3-dimethyl-N-(m-tolyl)isobenzofuran-1(3H)-imine (2g)


7.92 (d, J = 7.6 Hz, 1H), 7.53 (td, J = 7.4, 0.8 Hz, 1H), 7.49 –

7.41 (m, 1H), 7.30 (d, J = 7.5 Hz, 1H), 7.27 – 7.19 (m, 1H),

7.16 – 7.07 (m, 2H), 6.98 – 6.88 (m, 1H), 2.36 (s, 3H), 1.63 (s,

6H). 13C NMR (101 MHz, CDCl3) δ 157.7, 151.5, 146.7, 138.2, 131.9, 130.2, 128.6,


C17H18NO [M + H]+ 252.1383; found 252.1380. (Petroleum ether/EtOAc, 5/1).

(Z)-3,3-dimethyl-N-(m-tolyl)isobenzofuran-1(3H)-imine (2h)

Yellow oil (43.3 mg, 69%). 1H NMR (400 MHz, CDCl3) δ 7.95 (d,

J = 7.6 Hz, 1H), 7.55 (td, J = 7.4, 1.0 Hz, 1H), 7.48 (td, J = 7.5, 0.9

Hz, 1H), 7.31 (d, J = 7.5 Hz, 1H), 7.18 (dd, J = 16.9, 7.6 Hz, 2H),

7.12 – 7.05 (m, 1H), 7.01 (td, J = 7.4, 1.3 Hz, 1H), 2.25 (s, 3H),

1.60 (s, 6H). 13C NMR (100 MHz, CDCl3) δ 157.0, 151.8, 146.2,

131.9, 130.1, 129.7, 128.6, 125.9, 124.0, 123.4, 121.6, 120.3, 87.8, 27.9, 18.1. HRMS

(ESI): calcd. for C17H18NO [M + H]+ 252.1383; found 252.1379. (Petroleum

ether/EtOAc, 5/1).

(Z)-N-(3,4-dichlorophenyl)-3,3-dimethylisobenzofuran-

1(3H)-imine (2i)


7.89 (d, J = 7.6 Hz, 1H), 7.57 (td, J = 7.5, 1.1 Hz, 1H), 7.52 –

2f

O

NPh

2g

O

NMe

2h

O

N

Me

2i

O

NCl

Cl

S11

7.44 (m, 2H), 7.37 (d, J = 8.6 Hz, 1H), 7.32 (d, J = 7.6 Hz, 1H), 7.18 (dd, J = 8.6, 2.4

Hz, 1H), 1.65 (s, 6H). 13C NMR (100 MHz, CDCl3) δ 158.9, 151.6, 146.5, 132.4,

132.0, 130.1, 129.6, 128.8, 127.0, 125.6, 124.1, 123.6, 120.3, 89.1, 27.7. HRMS (ESI):

calcd. for C16H14Cl2NO [M + H]+ 306.0447; found 306.0443. (Petroleum ether/EtOAc,

5/1).

(Z)-3,3-dimethyl-N-(naphthalen-2-yl)isobenzofuran-

1(3H)-imine (2j)

Colourless oil (39.5 mg, 55%). 1H NMR (400 MHz, CDCl3)

δ 8.02 (d, J = 7.6 Hz, 1H), 7.85 (dd, J = 8.7, 4.4 Hz, 3H),

7.77 (d, J = 1.7 Hz, 1H), 7.63 – 7.51 (m, 3H), 7.49 – 7.39 (m,

2H), 7.36 (d, J = 7.5 Hz, 1H), 1.69 (s, 6H). 13C NMR (100 MHz, CDCl3) δ 158.2,

151.6, 144.5, 134.1, 132.0, 130.8, 130.1, 128.7, 128.1, 127.6, 125.8, 124.5, 124.1,



(Z)-3,3-dimethylisobenzofuran-1(3H)-one O-methyl oxime (2k)

Colourless oil (40.1 mg, 84%). 1H NMR (400 MHz, CDCl3) δ 7.65

(d, J = 7.6 Hz, 1H), 7.46 (td, J = 7.5, 1.0 Hz, 1H), 7.38 (td, J = 7.6,

0.9 Hz, 1H), 7.30 – 7.21 (m, 1H), 3.96 (s, 3H), 1.67 (s, 6H). 13C

NMR (100 MHz, CDCl3) δ 155.3, 149.4, 130.8, 128.5, 127.4, 121.7,

120.4, 90.3, 62.7, 27.9. HRMS (ESI): calcd. for C11H14NO2 [M + H]+ 192.1019; found


(Z)-N-phenyl-3'H-spiro[cyclohexane-1,1'-isobenzofuran]-3'-imine

(2l)

Colourless oil (59.6 mg, 86%). 1H NMR (400 MHz, CDCl3) δ 7.95 (d,

J = 7.5 Hz, 1H), 7.52 (td, J = 7.4, 1.2 Hz, 1H), 7.48 – 7.42 (m, 3H),

7.40 – 7.32 (m, 2H), 7.30 (d, J = 7.4 Hz, 1H), 7.16 – 7.06 (m, 1H), 1.85

– 1.70 (m, 9H), 1.47 – 1.32 (m, 1H). 13C NMR (100 MHz, CDCl3) δ 157.9, 151.3,

146.6, 131.6, 130.6, 128.7, 128.5, 124.2, 124.1, 123.9, 120.5, 89.6, 36.7, 24.9, 22.6.


ether/EtOAc, 5/1).

2j

O

N

2k

O

N OMe

2l

O

N Ph

S12

(Z)-N-phenyl-3'H-spiro[cyclopentane-1,1'-isobenzofuran]-3'-imine

(2m)

Colourless oil (49.3 mg, 75%). 1H NMR (400 MHz, CDCl3) δ 7.93 (d,

J = 7.6 Hz, 1H), 7.55 (td, J = 7.5, 1.0 Hz, 1H), 7.46 (td, J = 7.5, 0.8

Hz, 1H), 7.40 – 7.30 (m, 5H), 7.15 – 7.06 (m, 1H), 2.19 – 1.84 (m,

8H). 13C NMR (100 MHz, CDCl3) δ 157.9, 149.3, 146.6, 131.9, 131.1, 128.6, 128.5,

123.9, 123.8, 123.7, 120.4, 98.2, 40.1, 25.0. HRMS (ESI): calcd. for C18H18NO [M +

H]+ 264.1383; found 264.1377. (Petroleum ether/EtOAc, 5/1).

tert-butyl (Z)-3-(phenylimino)-3H-spiro[isobenzofuran-1,4'-

piperidine]-1'-carboxylate (2n)


MHz, CDCl3) δ 7.97 (d, J = 7.5 Hz, 1H), 7.53 (dt, J = 23.4, 7.4 Hz,

2H), 7.44 – 7.23 (m, 5H), 7.19 – 7.09 (m, 1H), 4.19 (s, 2H), 3.18 (s,

2H), 2.21 – 1.94 (m, 2H), 1.81 – 1.62 (m, 2H), 1.50 (s, 9H). 13C

NMR (100 MHz, CDCl3) δ 156.9, 154.7, 149.6, 146.2, 132.0, 130.6, 129.2, 128.6,

124.3, 124.2, 124.0, 120.5, 87.1, 79.9, 36.0, 28.4. HRMS (ESI): calcd. for

C23H27N2O3 [M + H]+ 379.2016; found 379.2012. (Petroleum ether/EtOAc, 5/1).

(Z)-6-bromo-3,3-dimethyl-N-phenylisobenzofuran-1(3H)-

imine (2o)


MHz, CDCl3) δ 8.07 (d, J = 1.6 Hz, 1H), 7.65 (dd, J = 8.1, 1.7

Hz, 1H), 7.39 – 7.31 (m, 4H), 7.18 (d, J = 8.1 Hz, 1H), 7.15 – 7.07 (m, 1H), 1.63 (s,

6H). 13C NMR (100 MHz, CDCl3) δ 156.1, 150.1, 146.2, 134.8, 132.5, 128.6, 127.1,

124.2, 123.7, 122.6, 121.9, 88.3, 27.7. HRMS (ESI): calcd. for C16H15BrNO [M + H]+


(Z)-5'-fluoro-N-phenyl-3'H-spiro[cyclohexane-1,1'-

isobenzofuran]-3'-imine (2p)


MHz, CDCl3) δ 7.60 (dd, J = 8.0, 2.0 Hz, 1H), 7.45 (d, J = 7.4 Hz,

2H), 7.36 (t, J = 7.8 Hz, 2H), 7.29 – 7.18 (m, 2H), 7.12 (t, J = 7.3

2m

O

N Ph

2n

O

N Ph

NBoc

2o

O

N PhBr

2p

O

N PhF

S13

Hz, 1H), 1.85 – 1.65 (m, 9H), 1.45 – 1.32 (m, 1H). 13C NMR (100 MHz, CDCl3) δ

163.15 (d, J = 246.8 Hz), 156.6, 146.9, 146.1, 132.99 (d, J = 9.6 Hz), 128.6, 124.3,

124.2, 122.05 (d, J = 8.9 Hz), 119.31 (d, J = 24.0 Hz), 110.55 (d, J = 24.1 Hz), 89.6,

36.8, 24.8, 22.6. HRMS (ESI): calcd. for C19H19FNO [M + H]+ 296.1445; found


(Z)-5'-bromo-N-phenyl-3'H-spiro[cyclohexane-1,1'-

isobenzofuran]-3'-imine (2q)


MHz, CDCl3) δ 8.09 (d, J = 1.6 Hz, 1H), 7.62 (dd, J = 8.1, 1.8 Hz,

1H), 7.48 – 7.42 (m, 2H), 7.39 – 7.32 (m, 2H), 7.20 – 7.09 (m,

2H), 1.90 – 1.64 (m, 9H), 1.43 – 1.33 (m, 1H). 13C NMR (100 MHz, CDCl3) δ 156.2,

149.9, 146.0, 134.6, 132.9, 128.6, 127.1, 124.3, 124.3, 122.5, 122.1, 89.7, 36.6, 24.8,

22.5. HRMS (ESI): calcd. for C19H19BrNO [M + H]+ 356.0645; found 356.0641.


(Z)-5'-methyl-N-phenyl-3'H-spiro[cyclohexane-1,1'-

isobenzofuran]-3'-imine (2r)


MHz, CDCl3) δ 7.65 (s, 1H), 7.34 (dd, J = 8.4, 1.1 Hz, 2H),

7.27 – 7.19 (m, 3H), 7.08 (d, J = 7.7 Hz, 1H), 7.03 – 6.94 (m,

1H), 2.33 (s, 3H), 1.72 – 1.59 (m, 9H), 1.33 – 1.19 (m, 1H). 13C NMR (100 MHz,

CDCl3) δ 158.0, 148.8, 146.7, 138.7, 132.7, 130.8, 128.5, 124.3, 124.1, 123.8, 120.3,



(Z)-5'-chloro-N-phenyl-3'H-spiro[cyclohexane-1,1'-

isobenzofuran]-3'-imine (2r)


MHz, CDCl3) δ 7.92 (s, 1H), 7.55 – 7.41 (m, 3H), 7.40 – 7.32 (m,

2H), 7.27 – 7.21 (m, 1H), 7.19 – 7.07 (m, 1H), 1.85 – 1.66 (m, 9H),

1.43 – 1.31 (m, 1H). 13C NMR (101 MHz, CDCl3) δ 156.3, 149.4, 146.1, 134.8, 132.7,

131.8, 128.6, 124.3, 124.2, 124.1, 121.8, 89.6, 36.6, 24.8, 22.5. HRMS (ESI): calcd.

2q

O

N PhBr

2s

O

N PhCl

2r

O

N PhMe

S14

for C19H19ClNO [M + H]+ 312.1150; found 312.1146. (Petroleum ether/EtOAc, 5/1).

(Z)-6'-chloro-N-phenyl-3'H-spiro[cyclohexane-1,1'-

isobenzofuran]-3'-imine (2t)

White solid (54.6 mg, 70%). M.p. = 92-94 °C. 1H NMR (400 MHz,

CDCl3) δ 7.87 (d, J = 8.2 Hz, 1H), 7.49 – 7.40 (m, 3H), 7.39 –

7.32 (m, 2H), 7.29 (d, J = 1.5 Hz, 1H), 7.16 – 7.08 (m, 1H), 1.85 –

1.65 (m, 9H), 1.46 – 1.31 (m, 1H). 13C NMR (100 MHz, CDCl3) δ 156.6, 152.8, 146.2,

137.8, 129.3, 128.6, 125.4, 124.3, 124.1, 121.1, 89.2, 36.6, 24.8, 22.4. HRMS (ESI):

calcd. for C19H19ClNO [M + H]+ 312.1150; found 312.1144. (Petroleum ether/EtOAc,

5/1).

(Z)-3-methyl-N-phenylisobenzofuran-1(3H)-imine (2u)

White solid (22.3 mg, 40%). M.p. = 77-79 °C. 1H NMR (400 MHz,

CDCl3) δ 8.00 (d, J = 7.6 Hz, 1H), 7.60 (td, J = 7.4, 1.0 Hz, 1H),

7.53 (t, J = 7.4 Hz, 1H), 7.45 – 7.31 (m, 5H), 7.17 – 7.10 (m, 1H),

5.68 (q, J = 6.6 Hz, 1H), 1.64 (d, J = 6.6 Hz, 3H). 13C NMR (100

MHz, CDCl3) δ 158.5, 147.8, 146.7, 131.9, 130.6, 128.7, 128.6, 124.0, 123.9, 123.3,



3,3-dimethylisobenzofuran-1(3H)-one (3)

White solid (32.4 mg, 80%). M.p. = 69-71°C. 1H NMR (400 MHz,

CDCl3) δ 7.93 – 7.79 (m, 1H), 7.74 – 7.65 (m, 1H), 7.52 (td, J = 7.5, 1.7

Hz, 1H), 7.45 (dd, J = 7.7, 1.8 Hz, 1H), 1.67 (s, 6H). 13C NMR (101

MHz, CDCl3) δ 169.8, 154.9, 134.1, 128.9, 125.6, 125.2, 120.7, 85.4, 27.3.


NMR Spectra

2t

O

N Ph

Cl

2u

O

N Ph

3

O

O

S15

1H NMR spectrum of compound 1a

-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.5f1 (ppm)

6.05

1.00

1.02

1.20

5.00

0.92

2.00

1.27

351.

2906

3.36

083.

3775

3.39

463.

4117

3.42

893.

4460

3.46

30

7.13

697.

1555

7.17

407.

2226

7.22

907.

2375

7.24

337.

2627

7.34

957.

3697

7.38

907.

4039

7.42

157.

4359

7.45

627.

4925

7.61

097.

6304

13C NMR spectrum of compound 1a

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

24.2

2

30.0

4

119.

8112

4.58

125.

8412

6.37

129.

1613

0.43

136.

1613

8.00

146.

96

168.

47

S16

1H NMR spectrum of compound 1b

-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.5f1 (ppm)

5.96

1.02

1.07

7.13

1.29

361.

3107

3.35

023.

3676

3.38

473.

4018

3.41

893.

4359

3.45

29

7.24

737.

2523

7.26

777.

2825

7.29

137.

4080

7.42

747.

4380

7.45

547.

4751

7.47

887.

5012

7.53

767.

5596

7.60

13

13C NMR spectrum of compound 1b

-20-100102030405060708090100110120130140150160170180190200210f1 (ppm)

24.1

9

30.0

6

117.

1212

1.37

125.

8712

6.34

126.

4513

0.62

132.

0813

5.77

137.

09

147.

04

168.

47

S17

1H NMR spectrum of compound 1c

-1.5-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.5f1 (ppm)

6.17

1.10

1.25

1.97

3.10

3.00

1.26

121.

2783

3.32

143.

3376

3.35

453.

3715

3.38

863.

4057

3.42

21

7.21

617.

2331

7.25

917.

2983

7.31

937.

3726

7.39

157.

4053

7.42

387.

4393

7.45

947.

5500

7.57

117.

6088

13C NMR spectrum of compound 1c

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

24.1

9

30.0

5

121.

0612

5.86

126.

3412

6.43

129.

1212

9.51

130.

5913

5.77

136.

58

147.

02

168.

50

1H NMR spectrum of compound 1d

S18

-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.5f1 (ppm)

6.06

8.96

1.07

1.16

5.97

2.05

1.29

991.

3170

1.36

16

3.39

303.

4100

3.42

723.

4443

3.46

143.

4785

3.49

56

7.24

807.

2547

7.26

267.

2680

7.27

267.

2821

7.29

097.

4147

7.41

987.

4363

7.44

677.

4611

7.48

137.

5106

7.57

397.

5954

13C NMR spectrum of compound 1d

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

24.2

230

.03

31.4

034

.45

119.

6412

5.82

125.

9712

6.32

126.

3913

0.34

135.

4013

6.29

146.

9014

7.62

168.

44

1H NMR spectrum of compound 1e

S19

0.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.0f1 (ppm)

6.21

3.05

1.08

2.00

1.04

6.09

1.26

351.

2806

2.33

85

3.35

213.

3692

3.38

633.

4035

3.42

063.

4377

3.45

48

7.15

277.

1732

7.20

627.

2131

7.22

057.

2262

7.23

147.

2401

7.24

657.

3830

7.40

707.

4136

7.42

147.

4416

7.44

427.

4857

7.50

661H NMR (400 MHz, CDCl3) δ3.48 – 3.31 (m, 1H).

13C NMR spectrum of compound 1e

-20-100102030405060708090100110120130140150160170180190200210f1 (ppm)

20.9

424

.22

30.0

3

119.

8912

5.81

126.

3212

6.40

129.

6213

0.34

134.

2513

5.47

136.

28

146.

92

168.

41

1H NMR spectrum of compound 1f

S20

0.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0f1 (ppm)

6.32

1.05

1.23

1.11

5.00

4.89

2.01

1.32

691.

3435

3.43

903.

4549

3.47

143.

4883

3.50

46

7.29

177.

3642

7.38

207.

3999

7.48

007.

4995

7.56

267.

5832

7.62

287.

6329

7.65

237.

7320

7.75

21

13C NMR spectrum of compound 1f

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

24.2

4

30.0

8

120.

1512

5.88

126.

4112

6.92

127.

2212

7.78

128.

8513

0.50

136.

1113

7.30

137.

5114

0.51

147.

02

168.

52

1H NMR spectrum of compound 1g

S21

-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0f1 (ppm)

6.09

3.00

1.03

1.00

2.00

3.94

2.02

1.30

521.

3224

2.40

33

3.39

273.

4097

3.42

683.

4439

3.46

103.

4781

3.49

52

6.99

757.

0162

7.24

587.

2588

7.26

607.

2714

7.27

817.

2859

7.29

127.

2969

7.39

237.

4156

7.43

577.

4492

7.45

537.

4633

7.55

06

13C NMR spectrum of compound 1g

-100102030405060708090100110120130140150160170180190200210220f1 (ppm)

21.5

624

.24

30.0

4

116.

8812

0.45

125.

3912

5.83

126.

3512

6.39

128.

9613

0.39

136.

2513

7.96

139.

1414

6.93

168.

50

1H NMR spectrum of compound 1h

S22

-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.5f1 (ppm)

6.11

3.00

1.07

1.00

4.00

3.01

0.94

1.32

641.

3434

2.32

94

3.44

103.

4481

3.46

483.

4818

3.49

883.

5158

3.53

263.

5491

3.55

53

7.10

067.

1165

7.14

197.

1604

7.17

887.

2562

7.27

627.

2919

7.31

247.

3319

7.47

127.

4788

7.49

948.

0384

8.05

83

13C NMR spectrum of compound 1h

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

17.9

324

.25

30.0

3

122.

9912

5.42

125.

8912

6.40

126.

4712

6.95

128.

9013

0.41

130.

6213

5.76

136.

2414

6.99

168.

57

1H NMR spectrum of compound 1i

S23

-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0f1 (ppm)

6.01

1.00

1.16

4.65

0.97

0.90

1.25

741.

2741

3.27

043.

2815

3.33

413.

3506

3.36

693.

4146

7.22

737.

2386

7.36

487.

3898

7.42

637.

4431

7.46

277.

5727

7.60

167.

6231

7.63

427.

6540

7.88

53

13C NMR spectrum of compound 1i

-20-100102030405060708090100110120130140150160170180190200210f1 (ppm)

24.1

8

30.0

5

119.

0012

1.50

125.

8912

6.29

126.

5112

7.72

130.

5813

0.80

132.

9313

5.36

137.

4314

7.12

168.

52

1H NMR spectrum of compound 1j

S24

-2.0-1.5-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.510.0f1 (ppm)

5.99

1.09

1.25

6.06

1.00

3.02

1.00

1.29

661.

3137

3.41

113.

4281

3.44

513.

4622

3.47

933.

4963

3.51

22

7.24

587.

2529

7.26

587.

2782

7.28

527.

4034

7.42

127.

4431

7.45

657.

4765

7.49

697.

5144

7.51

857.

6475

7.78

997.

8149

7.83

758.

3748

13C NMR spectrum of compound 1j

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

24.2

6

30.1

0

116.

6011

9.70

125.

1812

5.89

126.

4512

6.66

127.

6112

7.78

128.

9413

0.54

130.

7813

3.90

135.

4213

6.12

147.

10

168.

63

1H NMR spectrum of compound 1k

S25

-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.510.0f1 (ppm)

6.18

1.02

3.08

2.01

2.04

0.97

1.09

671.

1138

3.08

263.

0891

3.14

243.

1576

3.17

28

3.70

19

7.00

717.

0102

7.02

597.

0423

7.08

917.

1071

7.22

017.

2400

7.24

557.

2630

7.26

607.

2825

7.28

58

8.83

93

13C NMR spectrum of compound 1k

-20-100102030405060708090100110120130140150160170180190200210f1 (ppm)

24.0

8

29.9

4

64.4

6

125.

5612

6.12

127.

0813

0.68

132.

14

147.

53

168.

10

1H NMR spectrum of compound 1l

S26

0.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0f1 (ppm)

5.31

5.03

1.02

2.09

5.05

0.99

2.00

1.22

351.

2544

1.28

481.

3270

1.35

811.

3898

1.41

581.

4414

1.47

431.

5010

1.50

521.

7071

1.73

841.

7797

1.81

041.

8803

1.90

992.

9413

2.96

812.

9753

2.98

282.

9966

3.00

393.

0253

3.03

24

7.13

337.

1518

7.17

027.

2041

7.21

847.

2381

7.24

907.

3167

7.34

507.

3649

7.39

207.

4082

7.42

827.

5316

7.59

577.

6153

13C NMR spectrum of compound 1l

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

26.1

526

.79

34.6

1

40.5

3

119.

9212

4.55

125.

8012

6.58

127.

0312

9.16

130.

2913

6.33

138.

0614

5.96

168.

48

1H NMR spectrum of compound 1m

S27

0.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.5f1 (ppm)

4.17

2.01

2.00

1.00

1.96

5.07

2.01

1.10

1.55

281.

5749

1.59

231.

5985

1.62

591.

6332

1.63

831.

6505

1.65

751.

6671

1.68

951.

6988

1.73

751.

7469

1.78

291.

7894

1.79

552.

0473

2.06

792.

0722

2.08

722.

0949

3.35

863.

3799

3.40

013.

4194

3.44

25

7.11

627.

1346

7.15

317.

1720

7.18

257.

1923

7.20

187.

2123

7.22

237.

3206

7.34

097.

3532

7.35

987.

3713

7.39

047.

4001

7.58

277.

6022

7.64

21

13C NMR spectrum of compound 1m

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

25.9

0

35.3

1

41.9

5

119.

8612

4.54

125.

7112

6.40

126.

9212

9.15

130.

3513

6.98

138.

0714

4.76

168.

76

S28

1H NMR spectrum of compound 1n

-1.5-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.5f1 (ppm)

9.01

2.23

2.00

2.14

1.04

2.04

1.00

1.33

5.00

3.00

1.44

761.

5775

1.60

701.

6210

1.65

081.

7814

1.81

831.

8494

1.88

252.

6954

2.76

832.

7803

2.79

093.

1659

3.19

633.

2191

3.22

58

4.13

234.

1554

4.17

724.

1944

4.22

74

7.11

467.

1335

7.15

207.

1704

7.18

597.

2400

7.25

847.

2768

7.30

667.

3291

7.34

707.

3654

7.38

487.

4048

7.42

467.

4303

7.44

957.

5468

7.58

667.

6062

7.63

597.

6471

13C NMR spectrum of compound 1n

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

28.4

933

.30

38.5

9

79.4

3

119.

9312

4.74

126.

3312

6.65

127.

1012

9.22

130.

6213

6.22

137.

9214

4.33

154.

85

168.

06

1H NMR spectrum of compound 1o

S29

-3.0-2.5-2.0-1.5-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0f1 (ppm)

6.00

1.04

1.00

1.12

2.01

4.95

1.27

371.

2903

3.32

923.

3444

3.36

093.

3775

3.39

383.

3938

3.40

89

7.16

137.

1830

7.20

047.

2186

7.21

867.

2912

7.30

437.

3043

7.32

647.

3605

7.38

527.

4039

7.42

227.

4222

7.50

737.

5150

7.52

647.

5715

7.57

157.

6297

7.64

877.

6487

7.68

657.

6889

13C NMR spectrum of compound 1o

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

24.0

5

29.8

1

119.

2311

9.96

124.

8812

8.31

129.

1912

9.23

133.

3713

7.67

137.

8914

5.99

166.

77

1H NMR spectrum of compound 1p

S30

-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.510.010.5f1 (ppm)

5.01

5.02

1.01

3.00

2.99

2.01

1.02

1.10

511.

1305

1.15

921.

1884

1.21

921.

2493

1.27

511.

3038

1.33

211.

5961

1.61

881.

6254

1.66

001.

6848

1.72

641.

7493

2.75

722.

8211

2.91

172.

9192

6.90

736.

9286

6.96

616.

9858

7.03

457.

0516

7.06

917.

1476

7.22

177.

2400

7.25

717.

3875

7.39

067.

4611

7.47

977.

5738

7.67

817.

7048

7.70

827.

7639

7.79

52

13C NMR spectrum of compound 1p

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

26.0

626

.74

34.7

3

40.0

4

113.

3811

3.61

116.

9311

7.14

120.

1212

4.78

128.

6912

8.76

129.

1413

7.52

137.

5813

7.78

141.

59

159.

0816

1.53

167.

23

1H NMR spectrum of compound 1q

S31

-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.0f1 (ppm)

5.09

5.00

1.00

1.00

1.04

2.02

4.93

1.04

741.

0702

1.07

811.

1011

1.13

191.

1719

1.20

311.

2321

1.25

751.

2875

1.31

751.

5667

1.59

771.

6376

1.66

171.

7147

1.73

922.

7766

2.79

742.

8044

2.82

522.

8316

6.97

926.

9940

7.01

737.

0358

7.05

437.

1117

7.11

977.

1318

7.18

897.

2200

7.24

007.

2590

7.37

157.

3920

7.45

007.

4695

13C NMR spectrum of compound 1q

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

26.0

226

.66

34.4

8

40.2

0

119.

1912

0.02

124.

8612

8.96

129.

2212

9.38

133.

2513

7.69

138.

0014

5.01

166.

78

1H NMR spectrum of compound 1r

S32

-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0f1 (ppm)

5.20

5.05

3.01

1.01

1.00

3.01

1.91

1.02

2.00

1.19

131.

2145

1.24

511.

2532

1.27

571.

2840

1.31

901.

3503

1.38

201.

4027

1.42

501.

4578

1.48

851.

6178

1.69

911.

7304

1.77

181.

8019

1.86

151.

8902

2.33

76

2.92

922.

9504

2.95

742.

9786

2.98

57

7.09

017.

1000

7.13

237.

1507

7.16

917.

2143

7.22

957.

2500

7.26

857.

2898

7.34

797.

3677

7.38

697.

4726

7.59

697.

6164

13C NMR spectrum of compound 1r

-100102030405060708090100110120130140150160170180190200f1 (ppm)

20.8

626

.17

26.8

3

34.7

2

40.1

7

119.

8712

4.51

126.

9712

7.14

129.

1613

1.01

135.

4313

6.22

138.

0914

2.93

168.

58

1H NMR spectrum of compound 1s

S33

-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.0f1 (ppm)

5.31

5.04

1.01

1.00

5.00

3.00

1.20

461.

2122

1.23

521.

2652

1.28

631.

3034

1.33

481.

3638

1.38

891.

4183

1.70

091.

7320

1.77

031.

7991

1.84

261.

8672

2.89

312.

9166

2.92

352.

9378

2.94

462.

9657

2.97

202.

9923

7.14

867.

1670

7.18

557.

2951

7.30

607.

3177

7.35

187.

3572

7.36

827.

3867

7.58

117.

6003

13C NMR spectrum of compound 1s

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

26.0

426

.68

34.5

4

40.1

5

120.

0512

4.84

126.

5512

8.61

129.

2013

0.27

131.

3413

7.66

137.

7314

4.47

166.

96

1H NMR spectrum of compound 1t

S34

-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0f1 (ppm)

5.03

5.11

1.00

2.00

4.23

3.00

1.20

981.

2392

1.26

451.

2945

1.32

661.

3563

1.38

061.

4102

1.44

021.

6492

1.69

921.

7302

1.77

251.

7960

1.84

521.

8679

2.97

463.

0007

7.15

797.

1755

7.24

697.

2549

7.28

597.

2931

7.30

627.

3136

7.33

787.

3563

7.37

327.

5753

7.59

067.

6234

13C NMR spectrum of compound 1t

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

26.0

026

.63

34.4

2

40.4

6

120.

0112

4.78

125.

9212

7.43

128.

0112

9.19

134.

5813

6.30

137.

82

148.

21

167.

56

1H NMR spectrum of compound 1u

S35

-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0f1 (ppm)

3.11

2.06

1.00

1.07

5.03

3.00

1.21

741.

2212

1.23

621.

2400

1.24

841.

2549

1.25

87

2.81

212.

8304

2.84

31

7.11

357.

1312

7.14

977.

1930

7.21

107.

2285

7.23

607.

2426

7.27

277.

2916

7.31

757.

3358

7.35

507.

3746

7.39

087.

4077

7.58

137.

6000

7.69

27

13C NMR spectrum of compound 1u

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

15.9

4

26.3

9

119.

9612

4.56

125.

9012

6.67

129.

1212

9.67

130.

3913

6.24

138.

0614

2.58

168.

38

1H NMR spectrum of compound 1v

S36

0.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.5f1 (ppm)

3.00

3.00

4.00

3.01

2.47

26

7.15

257.

1696

7.18

797.

2187

7.23

997.

2586

7.36

197.

4144

7.43

137.

6231

7.64

027.

8946

13C NMR spectrum of compound 1v

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

19.8

2

120.

0112

4.52

125.

8512

6.71

129.

0713

0.22

131.

2013

6.34

136.

4413

8.10

168.

31

S37

1H NMR spectrum of compound 2a

-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.5f1 (ppm)

6.01

1.01

5.03

1.04

1.00

0.97

1.63

19

7.05

227.

0728

7.07

907.

0865

7.09

427.

1004

7.10

837.

1139

7.12

187.

1332

7.14

317.

2968

7.31

577.

3336

7.34

197.

3467

7.36

217.

3685

7.43

347.

4477

7.46

457.

4661

7.48

317.

4850

7.52

207.

5244

7.54

077.

5430

7.55

927.

5615

7.92

527.

9442

13C NMR spectrum of compound 2a

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

27.8

4

88.2

6

120.

2812

3.67

123.

8612

4.04

128.

5912

8.67

130.

2013

1.95

146.

8115

1.57

157.

88

S38

1H NMR spectrum of compound 2b

-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.5f1 (ppm)

6.00

1.91

1.15

2.99

1.00

0.99

1.63

43

7.19

847.

2057

7.21

077.

2223

7.22

757.

2346

7.28

497.

3026

7.32

157.

4179

7.42

517.

4302

7.44

187.

4469

7.46

797.

4699

7.48

657.

4888

7.53

427.

5368

7.55

297.

5554

7.57

157.

5740

7.89

497.

9139

13C NMR spectrum of compound 2b

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

27.8

1

88.6

6

116.

7912

0.33

124.

0512

5.55

128.

7612

9.94

131.

5913

2.18

145.

89

151.

57

158.

33

S39

1H NMR spectrum of compound 2c

-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.5f1 (ppm)

6.00

5.06

1.04

1.00

0.99

1.63

96

7.25

827.

2697

7.28

577.

3061

7.32

497.

4522

7.45

437.

4708

7.47

287.

4895

7.49

177.

5358

7.53

857.

5545

7.55

717.

5731

7.57

567.

8971

7.91

62

13C NMR spectrum of compound 2c

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

27.8

2

88.6

2

120.

3112

4.04

125.

1312

8.63

128.

7512

8.95

129.

9613

2.14

145.

37

151.

55

158.

30

S40

1H NMR spectrum of compound 2d

-1.5-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0f1 (ppm)

9.18

6.00

1.00

4.14

1.04

1.03

0.98

1.38

26

1.68

26

7.33

137.

3500

7.37

137.

3729

7.37

857.

3869

7.39

397.

4015

7.40

857.

4168

7.42

237.

4241

7.47

347.

4756

7.49

197.

4941

7.51

057.

5129

7.54

557.

5482

7.56

417.

5668

7.58

267.

5852

7.96

377.

9826

13C NMR spectrum of compound 2d

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

27.9

531

.52

34.4

0

88.1

3

120.

2512

3.62

124.

0312

5.44

128.

6113

0.52

131.

77

143.

8714

6.66

151.

4115

7.42

S41

1H NMR spectrum of compound 2e

0.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0f1 (ppm)

6.09

3.15

2.16

3.00

1.09

1.18

1.02

1.62

72

2.34

10

7.13

597.

1564

7.17

957.

2494

7.27

027.

2862

7.30

497.

4327

7.43

477.

4513

7.45

327.

4699

7.47

207.

5064

7.50

917.

5251

7.52

767.

5436

7.54

607.

9130

7.93

20

13C NMR spectrum of compound 2e

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

21.0

8

27.9

0

88.1

4

120.

2712

3.65

123.

9712

8.63

129.

2313

0.34

131.

8213

3.36

144.

10

151.

49

157.

62

S42

1H NMR spectrum of compound 2f

-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0f1 (ppm)

6.01

2.01

4.09

1.15

1.05

4.17

1.00

1.66

44

7.29

197.

2947

7.29

767.

3130

7.33

167.

3897

7.40

957.

4273

7.44

337.

4482

7.46

027.

4626

7.47

897.

4812

7.49

767.

5001

7.53

437.

5371

7.55

297.

5557

7.57

157.

5742

7.57

907.

5849

7.58

997.

6014

7.60

637.

6125

7.61

787.

6202

7.63

327.

6379

7.64

137.

6552

7.65

757.

9426

7.96

15

13C NMR spectrum of compound 2f

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

27.8

9

88.4

4

120.

2912

4.08

124.

2412

6.79

126.

8812

7.29

128.

7013

0.25

131.

9813

6.63

141.

1314

6.07

151.

5615

8.00

S43

1H NMR spectrum of compound 2g

0.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.5f1 (ppm)

6.03

3.04

1.01

1.94

1.17

1.03

1.01

1.00

0.96

1.62

73

2.36

10

6.90

786.

9263

6.94

496.

9641

6.97

947.

0805

7.10

087.

1208

7.13

497.

1555

7.19

437.

2097

7.22

877.

2448

7.24

747.

2690

7.28

817.

3069

7.42

867.

4379

7.45

517.

4736

7.51

227.

5145

7.53

097.

5330

7.54

947.

5513

7.91

267.

9316

13C NMR spectrum of compound 2g

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

21.5

5

27.8

6

88.1

8

120.

2712

0.46

124.

0112

4.37

124.

6712

8.39

128.

6413

0.25

131.

9013

8.25

146.

7515

1.58

157.

72

S44

1H NMR spectrum of compound 2h

-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0f1 (ppm)

6.00

3.02

0.92

1.03

2.03

1.12

1.00

1.00

0.97

1.59

77

2.24

65

6.98

556.

9888

7.00

397.

0071

7.02

227.

0254

7.05

897.

0800

7.09

287.

1095

7.11

197.

1495

7.16

827.

1914

7.21

067.

2975

7.31

637.

4559

7.45

807.

4745

7.47

657.

4931

7.49

537.

5310

7.53

377.

5497

7.55

237.

5682

7.57

087.

9383

7.95

72

13C NMR spectrum of compound 2h

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

18.1

7

27.9

5

87.8

9

120.

3312

1.68

123.

4212

4.06

125.

9912

8.64

129.

7913

0.11

131.

92

146.

2015

1.80

157.

01

S45

1H NMR spectrum of compound 2i

-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.5f1 (ppm)

6.08

1.02

1.00

0.99

2.00

1.01

1.00

1.64

80

7.16

407.

1699

7.18

547.

1914

7.31

167.

3306

7.36

277.

3841

7.45

597.

4618

7.47

437.

4763

7.49

307.

4953

7.54

807.

5507

7.56

687.

5693

7.58

547.

5880

7.87

917.

8982

13C NMR spectrum of compound 2i

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

27.7

7

89.1

3

120.

3612

3.60

124.

1212

5.66

127.

0112

8.85

129.

6613

0.12

132.

0313

2.42

146.

52

151.

64

158.

97

S46

1H NMR spectrum of compound 2j

-1.5-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.510.010.5f1 (ppm)

6.04

0.98

2.13

3.05

1.00

3.02

1.00

1.69

38

7.35

517.

3738

7.39

567.

3984

7.41

507.

4327

7.43

567.

4512

7.45

407.

4720

7.48

857.

4915

7.51

417.

5308

7.53

277.

5504

7.55

537.

5723

7.57

737.

5830

7.58

567.

6018

7.60

427.

6203

7.62

267.

7701

7.77

437.

8286

7.83

997.

8507

7.86

158.

0136

8.03

25

13C NMR spectrum of compound 2j

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

27.8

6

88.4

5

120.

2812

0.32

124.

1012

4.19

124.

5412

5.85

127.

6112

8.12

128.

7413

0.18

130.

8413

2.05

134.

1414

4.53

151.

62

158.

27

S47

1H NMR spectrum of compound 2k

-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.5f1 (ppm)

6.04

2.96

1.12

1.00

1.01

1.00

1.66

90

3.95

95

7.23

717.

2560

7.27

027.

3622

7.36

447.

3810

7.38

317.

3997

7.40

217.

4405

7.44

317.

4593

7.46

187.

4779

7.48

047.

6432

7.66

23

13C NMR spectrum of compound 2k

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

27.9

8

62.7

0

90.3

7

120.

4312

1.79

127.

4412

8.58

130.

89

149.

48

155.

36

S48

1H NMR spectrum of compound 2l

-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.5f1 (ppm)

1.07

9.17

1.00

1.01

2.05

2.92

1.00

0.97

1.37

551.

3906

1.39

601.

4087

1.41

631.

4409

1.73

801.

7459

1.75

591.

7628

1.79

061.

8249

1.83

21

7.08

697.

0897

7.09

267.

1081

7.12

347.

1263

7.12

927.

2940

7.31

267.

3290

7.33

367.

3379

7.35

437.

3679

7.37

297.

4382

7.44

327.

4459

7.45

667.

4591

7.46

417.

4672

7.47

517.

4778

7.50

087.

5039

7.51

957.

5223

7.53

807.

5407

7.93

667.

9554

13C NMR spectrum of compound 2l

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

22.6

024

.92

36.7

1

89.6

2

120.

5512

3.90

124.

1412

4.28

128.

5312

8.70

130.

6813

1.68

146.

6615

1.36

157.

91

S49

1H NMR spectrum of compound 2m

-1.5-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.510.0f1 (ppm)

8.09

1.00

4.94

1.00

1.00

0.97

1.88

001.

9047

1.91

831.

9252

1.93

321.

9470

1.95

031.

9591

1.97

201.

9907

1.99

502.

0037

2.01

452.

0314

2.05

972.

0751

2.08

092.

0939

2.10

002.

1126

2.13

192.

1431

7.07

627.

0804

7.08

437.

0939

7.09

767.

1012

7.11

017.

1148

7.11

887.

1451

7.31

247.

3151

7.33

187.

3369

7.35

467.

3598

7.36

347.

3757

7.38

077.

3850

7.44

307.

4449

7.46

177.

4635

7.48

037.

4823

7.52

887.

5313

7.54

757.

5499

7.56

607.

5684

7.91

877.

9377

13C NMR spectrum of compound 2m

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

25.0

7

40.1

2

98.2

5

120.

4512

3.73

123.

8512

3.97

128.

5512

8.60

131.

1213

1.97

146.

6914

9.36

157.

90

1H NMR spectrum of compound 2n

S50

0.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.5f1 (ppm)

9.00

1.98

2.20

2.00

1.98

1.02

5.00

2.01

0.97

1.49

661.

6544

1.71

331.

7471

1.97

342.

0155

2.03

822.

0465

2.06

98

3.17

75

4.18

66

7.10

337.

1066

7.12

117.

1242

7.13

867.

1420

7.16

287.

1815

7.26

307.

2669

7.28

447.

3030

7.33

657.

3538

7.37

147.

3746

7.39

307.

4103

7.41

347.

4829

7.50

167.

5203

7.54

147.

5599

7.57

837.

9571

7.97

59

13C NMR spectrum of compound 2n

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

28.4

8

36.0

7

79.9

2

87.1

3

120.

5312

4.05

124.

2012

4.33

128.

6412

9.23

130.

6113

2.06

146.

2714

9.60

154.

7715

6.92

1H NMR spectrum of compound 2o

S51

0.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.5f1 (ppm)

6.03

1.02

1.03

4.10

1.01

0.95

1.62

55

7.08

047.

0863

7.09

387.

1004

7.10

847.

1152

7.12

197.

1297

7.13

657.

1438

7.14

927.

1725

7.19

267.

3204

7.33

487.

3420

7.34

927.

3650

7.37

087.

6337

7.63

817.

6539

7.65

828.

0726

8.07

66

13C NMR spectrum of compound 2o

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

27.7

7

88.3

2

121.

9112

2.61

123.

7812

4.24

127.

1112

8.65

132.

5813

4.89

146.

2615

0.19

156.

14

1H NMR spectrum of compound 2p

S52

-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.5f1 (ppm)

1.04

9.03

1.01

2.12

2.02

1.96

1.00

1.33

811.

3625

1.37

831.

3924

1.41

061.

4259

1.75

441.

7777

1.82

51

7.10

397.

1221

7.14

047.

1850

7.19

067.

2060

7.21

157.

2273

7.23

637.

2486

7.25

687.

2690

7.33

777.

3580

7.37

677.

4435

7.46

217.

5850

7.59

027.

6050

7.61

00

13C NMR spectrum of compound 2p

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

22.6

024

.83

36.8

3

89.6

2

110.

4311

0.67

119.

1911

9.43

122.

0112

2.09

124.

2512

4.35

128.

6013

3.04

146.

1814

6.92

156.

6416

1.93

164.

38

1H NMR spectrum of compound 2q

S53

-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.5f1 (ppm)

1.05

9.15

2.05

2.06

2.00

1.00

0.94

1.33

631.

3611

1.37

701.

3925

1.40

801.

4245

1.75

351.

7763

1.80

671.

8191

1.82

75

7.10

347.

1063

7.10

907.

1246

7.14

007.

1429

7.14

567.

1668

7.18

707.

3379

7.34

207.

3586

7.37

217.

3772

7.43

967.

4422

7.45

607.

4604

7.46

357.

6092

7.61

367.

6293

7.63

378.

0848

8.08

88

13C NMR spectrum of compound 2q

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

22.5

124

.81

36.6

1

89.7

5

122.

1512

2.59

124.

3212

4.39

127.

1612

8.61

132.

9813

4.63

146.

0914

9.98

156.

20

1H NMR spectrum of compound 2r

S54

-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.0f1 (ppm)

1.18

9.09

3.02

1.00

1.11

3.05

1.99

1.00

1.21

571.

2582

1.27

761.

2868

1.29

901.

3186

1.63

451.

6427

1.66

401.

6949

1.70

101.

7335

2.33

14

6.97

116.

9738

6.97

666.

9921

7.00

767.

0104

7.01

327.

0709

7.09

027.

2101

7.21

187.

2194

7.22

397.

2331

7.24

007.

2538

7.25

877.

3332

7.33

577.

3540

7.35

707.

6477

13C NMR spectrum of compound 2r

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

21.2

322

.66

24.9

4

36.7

9

89.5

6

120.

3012

3.83

124.

1912

4.31

128.

5113

0.85

132.

7513

8.75

146.

7214

8.83

158.

08

S55

1H NMR spectrum of compound 2s

-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.5f1 (ppm)

1.10

9.24

1.00

1.12

2.03

2.91

1.00

1.33

961.

3686

1.38

431.

3984

1.41

531.

7238

1.72

711.

7824

1.83

18

7.11

067.

1283

7.14

557.

2258

7.22

837.

2460

7.24

827.

2570

7.26

137.

3407

7.34

367.

3608

7.37

887.

3823

7.44

567.

4677

7.48

407.

4884

7.52

397.

9213

13C NMR spectrum of compound 2s

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

22.5

324

.82

36.6

7

89.6

9

121.

8212

4.12

124.

2912

4.39

128.

6113

1.85

132.

7213

4.81

146.

1214

9.49

156.

32

S56

1H NMR spectrum of compound 2t

0.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.5f1 (ppm)

1.05

9.07

1.01

1.01

2.08

3.00

1.00

1.33

721.

3591

1.37

401.

3912

1.40

871.

7550

1.76

231.

7797

1.82

65

7.09

647.

0993

7.10

227.

1176

7.13

297.

1359

7.13

877.

2865

7.29

027.

3332

7.33

747.

3540

7.36

747.

3725

7.41

597.

4202

7.43

007.

4327

7.43

597.

4406

7.44

617.

4510

7.45

407.

8548

7.87

53

13C NMR spectrum of compound 2t

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

22.4

824

.81

36.6

1

89.2

4

121.

1112

4.19

124.

3012

5.42

128.

6012

9.33

137.

84

146.

2315

2.83

156.

68

S57

1H NMR spectrum of compound 2u

-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0f1 (ppm)

3.08

1.03

1.00

4.96

1.03

1.00

1.00

1.63

531.

6518

5.65

385.

6702

5.68

665.

7030

7.14

127.

3265

7.34

387.

3477

7.36

667.

3770

7.37

907.

3843

7.39

577.

3973

7.52

777.

5980

7.98

768.

0065

13C NMR spectrum of compound 2u

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

21.0

1

80.8

0

121.

0112

3.37

123.

9212

4.00

128.

6612

8.79

130.

6413

1.93

146.

7714

7.89

158.

56

S58

1H NMR spectrum of compound 3

-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0f1 (ppm)

6.06

1.00

1.02

1.01

1.00

1.67

32

7.43

377.

4381

7.45

287.

4573

7.50

177.

5059

7.52

057.

5246

7.53

917.

5434

7.66

987.

6733

7.68

867.

6920

7.70

717.

7109

7.71

347.

8580

7.85

957.

8770

13C NMR spectrum of compound 3

-100102030405060708090100110120130140150160170180190200210f1 (ppm)

27.3

3

85.4

6

120.

7412

5.22

125.

6712

8.94

134.

19

154.

97

169.

84

S59

4. X-ray single crystal data for product

2b

O

NBr

Table 1. Crystal data and structure refinement for 2b.

Identification code 2b

Empirical formula C16 H14 Br N O

Formula weight 316.19

Temperature 113(2) K

Wavelength 0.71073 A

Crystal system, space group Monoclinic, P2(1)/n

Unit cell dimensions a = 15.304(3) A alpha = 90 deg.

b = 5.8888(12) A beta = 106.59(3) deg.

c = 16.007(3) A gamma = 90 deg.

Volume 1382.6(5) A^3

Z, Calculated density 4, 1.519 Mg/m^3

Absorption coefficient 2.964 mm^-1

F(000) 640

Crystal size 0.200 x 0.180 x 0.120 mm

Theta range for data collection 1.624 to 27.899 deg.

S60

Limiting indices -19<=h<=20, -7<=k<=7, -21<=l<=21

Reflections collected / unique 14182 / 3309 [R(int) = 0.0632]

Completeness to theta = 25.242 100.0 %

Absorption correction Semi-empirical from equivalents

Max. and min. transmission 1 and 0.5159

Refinement method Full-matrix least-squares on F^2

Data / restraints / parameters 3309 / 0 / 175

Goodness-of-fit on F^2 0.983

Final R indices [I>2sigma(I)] R1 = 0.0434, wR2 = 0.0906

R indices (all data) R1 = 0.0598, wR2 = 0.0978

Extinction coefficient 0.0337(15)

Largest diff. peak and hole 0.745 and -0.584 e.A^-3

Table 2. Atomic coordinates ( x 10^4) and equivalent isotropic

displacement parameters (A^2 x 10^3) for shelxl.

U(eq) is defined as one third of the trace of the orthogonalized

Uij tensor.

________________________________________________________________

x y z U(eq)

________________________________________________________________

Br(1) 9110(1) 786(1) 8366(1) 34(1)

O(1) 7342(1) 8403(3) 5116(1) 25(1)

N(1) 8868(2) 7289(4) 5356(1) 23(1)

C(1) 8181(2) 8513(4) 4980(2) 21(1)

C(2) 8157(2) 10292(4) 4340(2) 21(1)

C(3) 8844(2) 11115(5) 4011(2) 29(1)

C(4) 8638(2) 12925(5) 3441(2) 35(1)

C(5) 7773(2) 13898(5) 3202(2) 33(1)

C(6) 7094(2) 13071(5) 3536(2) 29(1)

C(7) 7297(2) 11265(4) 4106(2) 22(1)

S61

C(8) 6720(2) 10080(5) 4594(2) 23(1)

C(9) 5912(2) 8828(5) 4010(2) 31(1)

C(10) 6448(2) 11674(5) 5227(2) 34(1)

C(11) 8842(2) 5758(4) 6027(2) 21(1)

C(12) 9350(2) 3764(5) 6096(2) 26(1)

C(13) 9410(2) 2255(5) 6771(2) 27(1)

C(14) 8981(2) 2765(5) 7397(2) 25(1)

C(15) 8480(2) 4730(5) 7352(2) 27(1)

C(16) 8409(2) 6212(5) 6667(2) 28(1)

________________________________________________________________

Table 3. Bond lengths [A] and angles [deg] for shelxl.

_____________________________________________________________

Br(1)-C(14) 1.904(3)

O(1)-C(1) 1.363(3)

O(1)-C(8) 1.458(3)

N(1)-C(1) 1.275(3)

N(1)-C(11) 1.412(3)

C(1)-C(2) 1.458(4)

C(2)-C(7) 1.385(4)

C(2)-C(3) 1.391(4)

C(3)-C(4) 1.380(4)

C(3)-H(3) 0.9500

C(4)-C(5) 1.391(4)

C(4)-H(4) 0.9500

C(5)-C(6) 1.386(4)

C(5)-H(5) 0.9500

C(6)-C(7) 1.378(4)

C(6)-H(6) 0.9500

C(7)-C(8) 1.507(4)

C(8)-C(9) 1.512(4)

S62

C(8)-C(10) 1.524(4)

C(9)-H(9A) 0.9800

C(9)-H(9B) 0.9800

C(9)-H(9C) 0.9800

C(10)-H(10A) 0.9800

C(10)-H(10B) 0.9800

C(10)-H(10C) 0.9800

C(11)-C(12) 1.395(4)

C(11)-C(16) 1.395(4)

C(12)-C(13) 1.382(4)

C(12)-H(12) 0.9500

C(13)-C(14) 1.378(4)

C(13)-H(13) 0.9500

C(14)-C(15) 1.379(4)

C(15)-C(16) 1.382(4)

C(15)-H(15) 0.9500

C(16)-H(16) 0.9500

C(1)-O(1)-C(8) 111.57(19)

C(1)-N(1)-C(11) 121.5(2)

N(1)-C(1)-O(1) 125.7(2)

N(1)-C(1)-C(2) 126.2(2)

O(1)-C(1)-C(2) 108.0(2)

C(7)-C(2)-C(3) 121.1(3)

C(7)-C(2)-C(1) 108.6(2)

C(3)-C(2)-C(1) 130.2(2)

C(4)-C(3)-C(2) 117.7(3)

C(4)-C(3)-H(3) 121.2

C(2)-C(3)-H(3) 121.2

C(3)-C(4)-C(5) 121.3(3)

S63

C(3)-C(4)-H(4) 119.3

C(5)-C(4)-H(4) 119.3

C(6)-C(5)-C(4) 120.5(3)

C(6)-C(5)-H(5) 119.7

C(4)-C(5)-H(5) 119.7

C(7)-C(6)-C(5) 118.4(3)

C(7)-C(6)-H(6) 120.8

C(5)-C(6)-H(6) 120.8

C(6)-C(7)-C(2) 121.0(3)

C(6)-C(7)-C(8) 130.3(3)

C(2)-C(7)-C(8) 108.7(2)

O(1)-C(8)-C(7) 103.1(2)

O(1)-C(8)-C(9) 108.0(2)

C(7)-C(8)-C(9) 113.7(2)

O(1)-C(8)-C(10) 107.1(2)

C(7)-C(8)-C(10) 111.8(2)

C(9)-C(8)-C(10) 112.5(2)

C(8)-C(9)-H(9A) 109.5

C(8)-C(9)-H(9B) 109.5

H(9A)-C(9)-H(9B) 109.5

C(8)-C(9)-H(9C) 109.5

H(9A)-C(9)-H(9C) 109.5

H(9B)-C(9)-H(9C) 109.5

C(8)-C(10)-H(10A) 109.5

C(8)-C(10)-H(10B) 109.5

H(10A)-C(10)-H(10B) 109.5

C(8)-C(10)-H(10C) 109.5

H(10A)-C(10)-H(10C) 109.5

H(10B)-C(10)-H(10C) 109.5

C(12)-C(11)-C(16) 118.3(2)

S64

C(12)-C(11)-N(1) 117.5(2)

C(16)-C(11)-N(1) 124.0(2)

C(13)-C(12)-C(11) 121.0(3)

C(13)-C(12)-H(12) 119.5

C(11)-C(12)-H(12) 119.5

C(14)-C(13)-C(12) 119.3(3)

C(14)-C(13)-H(13) 120.4

C(12)-C(13)-H(13) 120.4

C(13)-C(14)-C(15) 121.2(3)

C(13)-C(14)-Br(1) 119.9(2)

C(15)-C(14)-Br(1) 118.9(2)

C(14)-C(15)-C(16) 119.2(3)

C(14)-C(15)-H(15) 120.4

C(16)-C(15)-H(15) 120.4

C(15)-C(16)-C(11) 121.1(3)

C(15)-C(16)-H(16) 119.5

C(11)-C(16)-H(16) 119.5

_____________________________________________________________

Symmetry transformations used to generate equivalent atoms:

Table 4. Anisotropic displacement parameters (A^2 x 10^3) for shelxl.

The anisotropic displacement factor exponent takes the form:

-2 pi^2 [ h^2 a*^2 U11 + ... + 2 h k a* b* U12 ]

_______________________________________________________________________

U11 U22 U33 U23 U13 U12

_______________________________________________________________________

Br(1) 37(1) 33(1) 32(1) 8(1) 9(1) 0(1)

O(1) 13(1) 36(1) 26(1) 10(1) 6(1) 4(1)

N(1) 20(1) 28(1) 22(1) 1(1) 6(1) 2(1)

C(1) 18(1) 25(1) 19(1) -3(1) 5(1) 0(1)

C(2) 20(1) 26(1) 19(1) -3(1) 7(1) -2(1)

S65

C(3) 23(1) 41(2) 23(1) -3(1) 8(1) -4(1)

C(4) 38(2) 43(2) 24(2) 0(1) 10(1) -16(1)

C(5) 50(2) 24(2) 25(2) 4(1) 10(1) -3(1)

C(6) 34(2) 24(2) 28(2) -1(1) 7(1) 6(1)

C(7) 26(1) 22(1) 17(1) -4(1) 6(1) 0(1)

C(8) 18(1) 26(1) 25(1) 3(1) 7(1) 6(1)

C(9) 20(1) 34(2) 38(2) 1(1) 6(1) 1(1)

C(10) 35(2) 42(2) 29(2) -2(1) 16(1) 10(1)

C(11) 15(1) 26(1) 20(1) 0(1) 2(1) -1(1)

C(12) 23(1) 29(2) 28(1) -2(1) 10(1) -1(1)

C(13) 29(2) 24(1) 30(2) -2(1) 9(1) 4(1)

C(14) 23(1) 27(1) 22(1) 1(1) 3(1) -2(1)

C(15) 22(1) 38(2) 23(1) 0(1) 8(1) 4(1)

C(16) 27(2) 33(2) 26(1) 0(1) 9(1) 8(1)

_______________________________________________________________________

Table 5. Hydrogen coordinates ( x 10^4) and isotropic displacement parameters (A^2 x 10^3) for shelxl.

________________________________________________________________

x y z U(eq)

________________________________________________________________

H(3) 9435 10454 4173 34

H(4) 9095 13519 3206 42

H(5) 7648 15140 2807 40

H(6) 6503 13733 3375 34

H(9A) 6123 7781 3633 47

H(9B) 5485 9923 3650 47

H(9C) 5606 7969 4369 47

H(10A) 6147 10804 5588 51

H(10B) 6029 12832 4899 51

H(10C) 6994 12411 5602 51

H(12) 9659 3439 5673 31

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H(13) 9744 881 6804 33

H(15) 8186 5060 7787 33

H(16) 8061 7563 6631 34

________________________________________________________________

Table 6. Torsion angles [deg] for shelxl.

________________________________________________________________

C(11)-N(1)-C(1)-O(1) -5.1(4)

C(11)-N(1)-C(1)-C(2) 173.9(2)

C(8)-O(1)-C(1)-N(1) 178.6(2)

C(8)-O(1)-C(1)-C(2) -0.6(3)

N(1)-C(1)-C(2)-C(7) -178.3(2)

O(1)-C(1)-C(2)-C(7) 0.9(3)

N(1)-C(1)-C(2)-C(3) -2.0(5)

O(1)-C(1)-C(2)-C(3) 177.2(3)

C(7)-C(2)-C(3)-C(4) -0.3(4)

C(1)-C(2)-C(3)-C(4) -176.2(3)

C(2)-C(3)-C(4)-C(5) 0.0(4)

C(3)-C(4)-C(5)-C(6) 0.2(4)

C(4)-C(5)-C(6)-C(7) -0.1(4)

C(5)-C(6)-C(7)-C(2) -0.1(4)

C(5)-C(6)-C(7)-C(8) 177.3(3)

C(3)-C(2)-C(7)-C(6) 0.3(4)

C(1)-C(2)-C(7)-C(6) 177.1(2)

C(3)-C(2)-C(7)-C(8) -177.6(2)

C(1)-C(2)-C(7)-C(8) -0.8(3)

C(1)-O(1)-C(8)-C(7) 0.1(3)

C(1)-O(1)-C(8)-C(9) 120.7(2)

C(1)-O(1)-C(8)-C(10) -118.0(2)

C(6)-C(7)-C(8)-O(1) -177.2(3)

C(2)-C(7)-C(8)-O(1) 0.5(3)

S67

C(6)-C(7)-C(8)-C(9) 66.2(4)

C(2)-C(7)-C(8)-C(9) -116.2(2)

C(6)-C(7)-C(8)-C(10) -62.5(4)

C(2)-C(7)-C(8)-C(10) 115.2(2)

C(1)-N(1)-C(11)-C(12) 147.4(3)

C(1)-N(1)-C(11)-C(16) -38.6(4)

C(16)-C(11)-C(12)-C(13) 1.2(4)

N(1)-C(11)-C(12)-C(13) 175.5(2)

C(11)-C(12)-C(13)-C(14) -1.8(4)

C(12)-C(13)-C(14)-C(15) 1.2(4)

C(12)-C(13)-C(14)-Br(1) -176.7(2)

C(13)-C(14)-C(15)-C(16) -0.1(4)

Br(1)-C(14)-C(15)-C(16) 177.8(2)

C(14)-C(15)-C(16)-C(11) -0.5(4)

C(12)-C(11)-C(16)-C(15) 0.0(4)

N(1)-C(11)-C(16)-C(15) -174.0(3)

________________________________________________________________

Symmetry transformations used to generate equivalent atoms:

Table 7. Hydrogen bonds for shelxl [A and deg.].

____________________________________________________________________________

D-H...A d(D-H) d(H...A) d(D...A) <(DHA)

5. Analytical data of HRMS

When 2.0 eq TEMPO or BHT was added to the above reaction mixture, the reaction

was inhibited. When 2.0 eq TEMPO or BHT was added to the reaction of 1a, the

reaction was monitored by mass spectrometry experiment. Byproducts 4 and 5 were

observed by mass spectrometry, which corresponds to the products of the radical

captured by TEMPO and BHT. So we think this is a radical mechanism.

In addition, when we carried out the reaction in the solvent of DCE (Table 1, entry 1),

intermolecular oxidation product 6 was detected by mass spectrometry, suggesting

S68

that an alkyl cation had been generated.

Calc. 395.2693Found: 395.2689

O

NHPh

ON

[M + H]+

4

S69

Calc. 458.3054Found: 458.3053

O

NHPh

O

5

S70

Calc. 508.0380Found: 508.0375

O

NHPh

O

O

I

6

substituted benzamides for synthesis of ...general procedure for the preparation of compounds 1. r 1...

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