NÚMBER 21 Corporate Newsletter Instituto Bernabeu Group Spring-Summer 2011

ALICANTE

CARTAGENA

BENIDORM

ELCHE

SUMARY:

Recent scientific publications

Scientific participation

Special events:

- Chamber of Commerce Prize - Jovempa: 12 talented people

- Low-oxygen Incubators

Seminars and courses organised by IB

Professional & Personal Development

Charitable Foundación RB

Media

info@institutobernabeu.com www.institutobernabeu.com/en +34. 902 30 20 40

Recent scientific publications of the IB group

New International publication: Embryo metabolomics

One ofthe major limitationsof Assisted Reproduction techniques (ART) is the rates ofembryo implantation.By selecting an embryo with greater implantation capacity will increase thesuccess rates of ART as a whole. One method is morphological assessment; howeverthere are times whengood quality embryosfail toresult in a pregnancy.The aimof this study publishedin the journalMetabolomics is to look for biomarkersthat will allow us toidentify the implantation capacityof the embryo in a non—invasive manner by applying differentanalytical techniques:HPLC-MS,HPLC-MS/MSand NMR.The resultsof this studysuggest thatcertain amino acids in the embryoculture mediumact as markersof theirimplementation capacity. See publication

Newscientific publicationon chromosonic screening in pregnancies following ART

LastAprilthe journal, Progressin Obstetrics and Gynaecology, published arecent study by ourteam entitled,Screening chromosomes in the third quarter. Results in pregnancies afterassisted reproduction.The aim of this study was to test theeffectiveness of thecombined testfor aneuploidyin ART pregnanciesin the first quartercompared to spontaneouspregnancies. See publication

Scientific participation

ESHRE: European Fertility Conference

ESHRE is the most relevant international meeting point for Assisted Reproduction specialists. This year it was celebrated in Stockholm from the 3rd to the 6th of July. Instituto Bernabeu participated as in previous years with a scientific paper entitled,Embryo Transfer on Day 3 or day 5? A randomised prospective study.

IB Scientific papers at the SEGO National Conference

For another year our IB Group which is committed to the studyand to the advancement of applied science in clinical practice,presented a totalof 8 studies in the 31stannual meeting of SEGO (Spanish Society ofObstetrics and Gynaecology) which was heldfrom the 17thto the 20th

•

of Mayin Seville. As a reflection of ourmultidisciplinary approachto ourpatients,the titles of thepapers acceptedwere:

Prognostic value ofspermFISH in PGDforrecurrent miscarriages

• Chromosome

screening in the firstquarter. Outcomein pregnanciesafterassisted reproduction

• Clinical evaluation of the

use ofGnRHagonist in embryo cryotransfercycles

• Effectiveness of embryo

vitrificationon day 3versusday 5

• Blastocyst

transferdoes not improve outcomesin an IVF-ET programme

• Results ofgenotyping ofhuman papillomavirus(HPV) in our

patient group

• Uterusseptum,

2010-2011:Treatment and results

• Uterusseptum,

2010-2011:Epimediologyand diagnosis

Spanish Human Genetic Association Conference: Participation of IB BIOTECH

Our genetics services company, IB BIOTECHparticipated in this

conference withan oral submission entitled, Attainingthe genetic profileof embryos from IVF/ICSI cycles. Thefollowingworksweresubmitted

• Twin pregnancy

:

afterPGD ina carrier ofbalanced translocationX:autosome

.

• Study ofSNPsin the promoterof theCDH1geneand its relationship todiffuse gastriccancer

.

Dr Ten’s participationin the ASEBIR conference: Clinical uses of the blastocyct

On the 12th of MayourHead of Reproductive Biology, Dr JorgeTenparticipatedin the conference organised by ASEBIRentitled, Clinical Use of In vitro FertilisationBlastocystat Madrid'sGregorioMaranonHospitaland directedprofessionals inembryology andIVF.Dr Ten moderated the second session on the Blastocyst embryo: PGD and cryopreservation

.

Dr BelénLledó’s presentation: “Omicas” as a non-invasive instrument in selecting eggs and embryos.

We are currently experiencing, scientifically-speaking, the era of –omics: genomics, proteomics, transcriptomicsand metabolomics.

In her presentation Omicas as a non-invasive instrument in selecting eggs and embryos during Ferring’s 5th annual Symposium on Fertility which took place in Zaragoza on the 11th and 12th of March. These new techniques can help us to

understand embryo development and how we can apply that knowledge to improve implantation rates.

3rd Annual Conference on Assisted Reproduction ATTorrecárdenas Hospital

The conference was attendedby Dr Fernando Araico, Medical Director of Instituto Bernabeu, Cartagena. He participated on the roundtable named, “Preimplantation

genetic diagnosis (PGD). Who, when and

The 6th year of the Master’son Human Reproduction: “Egg Vitrification”

where?”.

Dr Jorge Ten, Director of Reproductive Biology at the Instituto Bernabeu has taken part again this year in the Master’s, organised by theSpanish Fertility S

Participation in the 11th Annual National Meeting of patients suffering from Marfan syndrome

ocietyand the Facultyof Medicine at the Complutense University of Madrid. His lecture talked about the basic aspects of egg vitrification.

The Associationof People Affected byMarfanSyndrome(SIMA) heldits 11th ANNUAL STATE MARFAN SYNDROME MEETING 2011 and requested again our participation.In his presentationDrRafaelBernabeu gave the definition of Preimplantation Genetic Diagnosis (PGD)and the alternatives for patients withgenetic diseases if they want offspring not to develop the disease.Instituto Bernabeu had the world'sfirst birthin February 2006 of a child freeofMarfansyndrome

Our Charitable Foundation

.

was also invited to present IB’s experiences and sincelast May has agreed to donate to the association one PGD treatment to Marfanpatientswholack financial means to access these elaboratetechniques.

SómnicaBernabeuexplained the process andthe experience offivecouples whohave so farbenefited from thisagreement.

Dr. Jorge Ten´s presentation: Current evaluation of Genetic Diagnosis

The doctor gave his presentation as partof the 3rd Annual Update onReproductive Medicine for Healthcare Professionalsorganised by theHospitalUniversitario de laRibera and took placeon Thursday17 February.

Dr Ten’s presentation updated PreimplantationGenetic Diagnosis (PGD) and the assessment of

clinical outcomeswhich can be expected depending on the different options taken. He alsoreviewed thenewmethods of detectingchromosomal abnormalitiesand the geneticlevelthat allows a scalable and efficient, comprehensive embryonic diagnosis.

Dr Joaquín Llácer’s participation in the Course “Current Issues in Fertility and Assisted Reproduction”

OnFebruary 3rd, Dr Joaquin Llácer was a speaker on the course, "Current Issues in Fertilityand Assisted Reproduction."This course was organisedby the Universities of Alcalá deHenares and MadridAutonomousUniversity Hospital Santa Cristina. Experts from around the country meet every yearto learn about the most innovative aspectsof the specialty.

The speechDr JoaquinLlácer gave was on

the newovarian stimulation protocols which focus on thepatient,while maintaining efficiencyand enhancingthe comfort and safetyof treatments.

1st Southeast Meeting on Assisted Reproduction

This meetingtook place inAlmeriathe past28thand 29th of January and was directed at professionals inassisted reproduction. It was attendedby DrFernandoAraico who is the directorof Instituto Bernabeu in Cartagena.

DrAraico’s lecture, "Adjuvants factorsthatimprove IA(Artificial Insemination) outcome", took place in thesecondsession on "SpecialSituationsin AI", moderatedby DrVicenteMaldonado

(URAHead oftheCHCiudad de Jaén

).

6th ANACER Conference 2011: Participation of our Group

The past 2nd and 3rd

Dr Rafael Bernabeu was one of the speakers at the medical clinic session, "Presentation and discussion of clinical cases" and Dr Jorge Ten was a moderator of the session concerning the biology & human reproduction laboratory, entitled "Review of the IVF Laboratory: Analysis of culture media, incubators, oil,).

ESPECIAL EVENTS

of June in Palma de Mallorca, the annual meeting of ANAK took place. ANAK is the Spanish network of experts in assisted reproduction.

Chamber of Commerce awards IBBIOTECH in the category of innovator

TheAlicanteChamber of Commercehas recognised the geneticand researchcompanyof the IB group as theinnovatorof 2010.In thatsame year IB BIOTECH’s embryo metabolomics programme by the SEF.

IB BIOTECHwas one of thefirst international companies to offer awide range ofgenetic services through Internet access, providingsimplicity andreducing testingcosts which in the was restrictedto the hospital environment.

The genetic services of IB BIOTECHcoverthe fieldof clinical geneticsand their application tothe branchesof human fertility, gynaecology, paediatrics, and oncology,etc.

The"Night of Alicante’s Economy" held attheADDAwas a night of awards presented annually bythe Chamber of Commerce in Alicante province.Almost90 companies applied to this37th edition.The award was presented by COEPApresident, Rafael

MartínezBern.

Seminar JOVEMPA - 12 talented people in Alicante – Dr Rafael Bernabeu

The seriesaims to present twelve talented people

to the publicwith a cast ofpersonalities that have revolutionisedour area through theirinnovation,originality and their international repercussions.12talented people is a cycle ofinterviews conductedby journalist, Mr MaríaJoséPerea.

Newembryo incubators for culture at low oxygen concentrations

We have installed in our IVF laboratory state-of-the-art incubatorsfor embryo cultureat lowoxygen concentrations.This equipment is designed to maintainconditions similar tothose foundin utero, resultingin betterembryo quality andhigher success ratesthan those obtained withconventionalincubators.They are best used forpatients with a worseprognosis, such asthose who have sufferedrepeatimplantation failure(RIF) or thosewho respondminimally tostimulation protocols, resulting in a low number of eggs (

poor responders).

SEMINARS & COURSES ORGANISED BY IB

Training: New techniques in Reproduction for laboratory technicians

For another year IB held a training sessionforparamedicson 6April in theauditorium of Instituto Bernabeu. The session presentednew developmentsin laboratory techniques in the area ofReproductive Medicine.

This year, the day of lectures was complemented bya two-hour visit to the laboratories ofIBBiotech.Studentswere able to experience in situ the technical and professional

skills used by the IB team in order to achieve their excellent results.

IB Training: New techniques in Assisted Reproduction for Nursing Auxiliaries

On May 10, another of ourtraining sessions was held on new techniques of assisted reproductionfornursing assistants. It presented the most important factors in terms of new techniques, advances and

patient treatment in the field. Continuing education coursesare funded byour Charitable Foundation.

Conference: Assisting at Birth in the 21st Century: New alternatives

Dr Francis Sellers was responsible for organisingthis conference aimed at midwives and nurses, which was a hit by the massive attendance and the interest of the discussed topics.

It was held onThursday April the 28th and different professionals participated in the event and shared their particular experience in their respective maternity wards. More information

Conference: “Being overweight & Fertility”

On Thursday, February the 17th a meeting-debate on the influence that being overweight hason fertilitytook place at IB in Alicante.

Obesity increases the risk ofmenstrual abnormalities, infertility and abortion. When pregnancy occurs there is an increasedrisk of complications for both the mother and the new born and the likelihood of birth defects is multiplied by 3.

All these important issues were covered in the conference by the experts in an open discussion led by DrJoaquinLlácer(Medical Director of theInstituto Bernabeu in Elche). The specialists were DrPilarMatallín(Coordinator of the Reproduction Unitof theAlicante GeneralHospital), DrFedericoPerez-Milan(HospitalGregorioMarañónand President of theSpanish FertilitySociety)and DrPinoNavarro (Director, Department ofEndocrinologyand Nutrition,Instituto Bernabeu). Download the course programme

PROFESSIONAL & PERSONAL DEVELOPMENT

Training agreement between IB BIOTECH and Alicante University

FromJune the 9th, AlicanteUniversity students can now complete theirtraining at IBBiotech, the genetic services arm of Instituto Bernabeu. Our goal, as always,is to continuethe professional development ofstudents who demonstratea professional interest inthe field ofMolecularBiologyand Genetics.

In orderto offerstudents thehighest quality of training, andgiven the numerousinscriptions of students

nationwide, we conducted athorough selection process sothey can have personalised learning process as well as continuous assessment.

The training process is a chance for both the company as well as the students to evaluate future professional opportunities.

Our Charitable Foundation organised a press conference to present the beneficial acts to celebrate March’s Women’s Month

The Medical Director of the Bourn Hall Clinic in Cambridge – the Clinic recognised by the Nobel Prize for Medicine in 2010, Dr Thomas Mathews and the soprano, Ana Mª Sánchez were the invitees this year in 2011.

Visit and presentation by Dr Thomas Mathews

The medical director, DrThomas Mathews, of the Bourn Hall Clinic, Cambridge – the clinic recognised with a Nobel Prize for Medicine in 2010 –openedtheevents planned for March to celebrate Women’s Month organised by Instituto Bernabeu.

On Friday March 25 at 20:00 a talk-debate was held on “The history ofIn VitroFertilisationand its potential inthe future"by DrThomasMathews. It was heldin the county auditorium (ADDA).

Bourn Hall was the first clinic in the world to achieve in vitro fertilisationin 1978.Awarded theNobel Prize for Medicine2010.

Acts to celebrate Women’s Month. A concert by the soprano, Ana María Sánchez

In March our Charitable Foundationinvitedthe prestigiousconcertsoprano, AnaMaríaSánchez, to Alicante to sing in the CountyAuditorium(ADDA).The Concert "Heartof a Woman"took placeon Wednesday, March 30that 20:30and showedthroughLieder,songs, melodies,ariasand romances, the different

emotional states that a woman goes through throughout her life.Thesopranowas accompaniedon piano by Ms Itziar Barredo.

Media

These are some of the press clippings which have appeared in the press over the last few months. We have also added the links in order for you to download the complete articles.

Marfansyndrome - yearly meeting

http://www.elperiodic.com/benidorm/noticias/111126_asociacion-sindrome-marfan-celebra-encuentro-estatal-benidorm.html

http://gn.prensaynoticias.com/benidorm/bienstar-social/17359-la-asociacion-sindrome-de-marfan-celebra-su-encuentro-estatal-en-benidorm.html

http://www.cominet.org/noticias/default.asp?id=673&mes=3&anyo=2011

Acts for the month of March organised by our Charitable Foundation

http://www.diarioinformacion.com/alicante/2011/03/26/tiempo-ninos-les-ocultaba-habian-nacido-fecundacion-in-vitro/1108955.html

http://www.laverdad.es/albacete/20110329/mas-actualidad/cultura/cerca-7300-personas-pasado-201103291814.html

http://www.diarioinformacion.com/cultura/2011/03/30/adda-concentra-7300-personas-ciclo-inaugural-puertas-abiertas/1110230.html

http://www.diarioinformacion.com/cultura/2011/03/31/mujer-lirica-adda-voz-soprano-ana-maria-sanchez/1110626.html

http://www.diarioinformacion.com/alicante/2011/03/11/bernabeu-trae-premio-nobel-thomas-mathew/1103639.html

http://www.laverdad.es/alicante/v/20110311/provincia/padre-primera-fecundacion-vitro-20110311.html

http://www.cunoticias.com/noticiasde/fundacion-rafael-bernabeu.php

http://www.ladipu.com/Noticia.aspx?id=40076

http://www.ladipu.com/Noticia.aspx?id=40066

http://www.intercomarcal.com/ii.php?accion=1&codigo_noticia=34686&m=n

http://www.coma.es/index.php?menu=tablon&apartado=ver_anuncio&id=6077&PHPSESSID=e3f3007e392d903bef415736c7df05f0

http://www.elperiodic.com/palicante/noticias/110769_fundacion-rafael-bernabeu-celebrara-adda-conferencia-thomas-mathew-concierto-soprano-sanchez.html

http://www.alacalle.com/ficha.aspx?canal=palabra&id=15997

http://www.alacalle.com/listadoscomp.aspx?canal=arte&entidad=1819

JOVEMPA’s 12 talented individuals

http://www.jovempa.org/calendario_detalle.php?not=159

http://blog.fundacionquorum.es/2011/02/viii-jornada-12-talentos-alicantinos-rafael-bernabeu/

http://www.alacalle.com/ficha.aspx?canal=palabra&id=15399

http://www.emprenemjunts.es/index.php?op=14&n=1863

http://www.ceei-elche.com/index.php?op=14&n=1863&v=5

http://www.jovempa.org/noticias.php?pag=1&not=204

Midwife training

http://www.diarioinformacion.com/alicante/2011/04/29/necesario-humanizar-partos-dar-importancia-madre/1121149.html

Dr Araico’sconference inAlmeria

http://www.elalmeria.es/article/almeria/967044/centenar/profesionales/participan/las/iii/jornadas/reproduccion/asistida/complejo/hospitalario/torrecardenas.html

IB Cartagena

http://www.laverdad.es/murcia/v/20110619/cartagena/aumentan-problemas-fertilidad-contaminacion-20110619.html

http://www.laverdad.es/murcia/v/20110619/cartagena/intentan-evitar-embarazos-multiples-20110619.html

Others

http://www.laverdad.es/murcia/v/20110425/region/romper-cadena-enfermedad-20110425.html

http://www.lainfertilidad.com/contenido/la-donante-de-ovulos-en-el-instituto-bernabeu-un-cuidado-muy-especial.html

http://healthznews.com/instituto-bernabeu-fertility-and-gynaecology-in-spain.html

http://www.diarioinformacion.com/alicante/2011/02/22/apedrearon-autobus/1097693.html

http://www.lookfordiagnosis.com/images.php?term=Biologia+Molecular&lang=3

http://masquemedicos.com/videos/seguro-medico/caser/

http://especialbebes.tv/videos-ext/sKjlk1xxbv4-vitrificaci-n-de-vulos-preservar-la-fertilidad-en-el-mejor-momento

http://especialbebes.tv/videos-ext/741mp2Ug6Rk-gimnasia-para-embarazadas-instituto-bernabeu

http://www.pysnnoticias.com/2011/07/08/la-leptina-una-molecula-organica-que-revoluciono-la-manera-de-perder-peso/ (nuestro video de DGP).

http://es.paperblog.com/cuantas-mas-frutas-y-verduras-mas-calidad-de-semen-284523/

http://www.google.com/url?sa=X&q=http://news-es.karameloo.com/actualidad/ultima-hora/aliados-y-enemigos-de-la-calidad-del-semen.html&ct=ga&cad=CAcQARgBIAEoATAAOABAs-7q8ARIAVgAYgVlcy1VUw&cd=y9Q_W9_Yhx4&usg=AFQjCNECUaTp5GG8eK5zBoPkJPjOB3vopg

http://uploadmachine.com/bernabeu.html

http://eu.keegy.com/tag/instituto-bernabeu/

Chamber of Commerce Prize for IB BIOTECH

http://www.diarioinformacion.com/economia/2011/07/05/camara-celebra-hoy-premios-anuales-gala-800-invitados/1145354.html

http://www.diarioinformacion.com/economia/2011/06/30/camara-reconoce-labor-instituto-calzado-presidente-inaer-luis-minano/1143776.html

http://www.glovoz.com/search/inescop

http://www.diariocriticocv.com/noticias/luis-minano/caara-de-alicante/not361986.html

http://www.finanzas.com/noticias/economia/2011-06-29/512867_instituto-bernabeu-biotech-inescop-entre.html

http://www.abc.es/agencias/noticia.asp?noticia=863197

http://www.elcorreo.com/agencias/20110629/economia/instituto-bernabeu-biotech-inescop-entre_201106291519.html

http://www.adn.es/local/valencia/20110629/NWS-0918-INESCOP-Instituto-Comercio-Bernabeu-Biotech.html

http://www.periodicosantapola.es/spip.php?article3641

http://www.veintepies.com/secciones/alicante_more.php?id=64200_0_30_0_M

http://www.valenciaplaza.com/ver/29232/La-C%C3%A1mara-de-Comercio-de-Alicante-premia-al-Centro-Comercial-Ferri-y-al-Instituto-Bernabeu-Biotech.html

Instituto Bernabeu Group

The European institution of reference in Reproductive Medicine specialised in accomplishing individual solutions