7/25/2019 Summary Charts of Chemical Mediators in Acute Inflammaton (Robbins)

1/2

Table 3-4 Principal Mediators of Inammation (Robbins &

Cotran Pathologic Basis of isease! "th #d$

Mediator Source Action

HistamineMast cells, basophils,

platelets

Vasodilation, increased vascular permeability,

endothelial activation

Prostaglandins Mast cells, leukocytes Vasodilation, pain, fever

Leukotrienes Mast cells, leukocytesIncreased vascular permeability, chemotaxis,

leukocyte adhesion, and activation

Cytokines !"#,

IL$%, IL$&'

Macrophages,

endothelial cells, mastcells

Local( endothelial activation expression of

adhesion molecules') *ystemic( fever, metabolicabnormalities, hypotension shock'

ChemokinesLeukocytes, activated

macrophagesChemotaxis, leukocyte activation

Platelet$activating

factorLeukocytes, mast cells

Vasodilation, increased vascular permeability,

leukocyte adhesion, chemotaxis, degranulation,

oxidative burst

ComplementPlasma produced in

liver'

Leukocyte chemotaxis and activation, direct target

killing membrane attack complex', vasodilation

mast cell stimulation'

+ininsPlasma produced in

liver'

Increased vascular permeability, smooth muscle

contraction, vasodilation, pain

7/25/2019 Summary Charts of Chemical Mediators in Acute Inflammaton (Robbins)

2/2

Table 3-% Role of Mediators in ierent Reactions of

Inammation (Robbins & Cotran Pathologic Basis of

isease! "th #d$

Reaction of Inflammation Principal Mediators

Vasodilation Histamine

Prostaglandins

Increased vascular permeability Histamine and serotonin

Ca and C-a by liberating vasoactive amines from mast

cells, other cells'Leukotrienes C . , / . , 0 .

Chemotaxis, leukocyte recruitment andactivation

!"#, IL$%

Chemokines

Ca, C-a

Leukotriene 1 .

#ever IL$%, !"#

Prostaglandins

Pain Prostaglandins

1radykinin

!issue damage Lysosomal en2ymes of leukocytes

3eactive oxygen species