sumo defeats protein aggregates that typify parkinson’s disease and impaired activity of the...
TRANSCRIPT
SUMO DEFEATS PROTEIN AGGREGATES THAT
TYPIFY PARKINSON’S DISEASE AND IMPAIRED
ACTIVITY OF THE PROTEIN MTOR A STRAIN ON THE
HEART
PLUTARCO ANDRES UZCATEGUIMEDICAL STUDENT
INTRODUCCION
Small proteins called SUMO can
be one solution for neurodegenerativ
e diseases
Some drugs used for a cancer
treatment can produce heart dysfunction
Impaired Activity of the Protein MTOR a Strain On the Heart
Drugs that inhibit the protein MTOR, which are used to treat several forms of cancer, might have adverse effects on heart function in patients with ongoing heart dysfunction.
Impaired Activity of the Protein MTOR a Strain On the Heart
It was found that adult mice lacking MTOR in their heart muscle cells developed a fatal heart condition.
Impaired Activity of the Protein MTOR a Strain On the Heart
Disease was associated with accumulation of the protein 4E-BP1, which is an inhibitor of protein generation that is normally held in check by a protein complex containing MTOR.
Impaired Activity of the Protein MTOR a Strain On the Heart
Thus, decreased MTOR activity impairs the protective heart response to stress, by enhancing 4E-BP1 activity, providing a potential new therapeutic strategy for improving heart function in patients with heart failure.
Observation
These findings, although they
appear simple, are very important when talking about future treatment of
neurodegenerative diseases. You can also change the way you
think about the disease, and
encourage the investigation
of other risk factors.
SUMO Defeats Protein Aggregates That Typify
Parkinson’s Disease Insoluble protein
clusters are the hallmarks of several neurodegenerative diseases. In PD, neurons harbor insoluble clumps of the protein alpha-synuclein.
SUMO Defeats Protein Aggregates That Typify
Parkinson’s Disease A possible clue for
PD came when researchers overexpressed alpha-synuclein in human kidney cells and found that the protein was modified by the addition of the small, ubiquitin - like molecule SUMO.
SUMO Defeats Protein Aggregates That Typify
Parkinson’s Disease Researchers tested
whether sumoylating purified alpha-synuclein hindered its clustering into fibrils, filaments similar to those detected in neurons of PD patients.
SUMO Defeats Protein Aggregates That Typify
Parkinson’s Disease After several
experiments, we found that SUMO protein binds to two sites in alpha-synuclein ant that alterations in this protein causes apoptosis in cells of the substantia nigra, as a parkinson’s disease.
Observation
There are many risk factors for heart disease, these
studies are important to minimize the risks when
administering a treatment to more
aggressive diseases. It is also important to
realize that if there are drugs that
inhibit MTOR, there may be other drugs
that inhibit other proteins and that may cause disease of
any kind.
Medical utility
These developments are of great importance, since we find progress towards an adequate treatment of diseases very important and everyday life as parkinson’s disease and heart disease.
Medical utility
The SUMO proteins can reduce the pileups formed by the alpha-synuclein protein. The alpha-synuclein protein pileups are characteristic from some diseases like Parkinson’s disease.
Medical utility
In the near future, we can provide a better care to patients treated with MTOR inhibitor drugs, because we can take consideration whether to apply a treatment whit these drugs to patients with heart disease.
Medical utility
The study of various proteins and their function in the organism has recently been of great importance, because thanks to these advances has gained valuable information from certain treatments, which could be effective in diseases that are very important today.
Bibliography
Science. ‘’SUMO Defeats Protein Aggregates That Typify Parkinson’s Disease’’. ScienceDaily. July 15, 2011.
SScience. ‘‘Impaired Activity of the Protein MTOR a Strain on the Heart’’. ScienceDaily. July 15, 2011.
Thank you