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Programme

Sunday 07 October 2012 16:00 - 17:45 Arrival and Registration

ATC Registration Desk

17:45 - 19:00 BUFFET DINNER ATC Foyer

19:00 - 19:15 Welcome ATC Auditorium

19:15 - 21:30 KEYNOTE SESSION ATC Auditorium

19:15 - 20:00 Mechanisms of 3'->5' RNA degradation 1Elena Conti Max Planck Institute of Biochemistry, Germany Talk kindly sponsored by Open Biology

20:00 - 20:45 Involvement of Low Complexity Polypeptide Sequences in the Formation of RNA Granules

2

Steven McKnight

UT Southwestern Medical Center, United States of America

20:45 - 21:30 Post-transcriptional gene regulation by small RNAs and RNA binding proteins

3

Nikolaus Rajewsky

Max Delbruck Center for Molecular Medicine, Germany

21:30 - 23:00 Drinks and Poster "Sneak Preview"

ATC Foyer, Helices A & B

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EMBO|EMBL Symposium The Complex Life of mRNA

Monday 08 October 2012 09:00 - 13:10 SESSION 2 - RNA Surveillance and Decay

Chair: Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany ATC Auditorium

09:00 - 09:25 Viral Noncoding RNPs 4Joan Steitz Yale University, United States of America

09:25 - 09:50 Eukaryotic mRNA Turnover 5Roy Parker HHMI/University of Colorado Boulder, United States of America

09:50 - 10:15 Production and destruction of RNA in human nuclei 6Torben Jensen Aarhus University, Denmark

10:15 - 10:45 COFFEE BREAK ATC Foyer

10:45 - 11:10 Tales from the Cellular Underworld: The Importance of mRNA Decay

7

Lynne Maquat University of Rochester Medical Center, United States of America

11:10 - 11:25 DHX34 activates NMD by promoting the transition from the SURF to the DECID complex

8

Nele Hug MRC HGU, IGMM, United Kingdom

11:25 - 11:50 Reining in the mRNA decay enzymes: Proteolytic control ofdecapping

9

Jens Lykke-AndersenUniversity of California San Diego, United States of America

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Programme

11:50 - 12:05 Uridylation prevents the formation of aberrant mRNAs by protecting deadenylated mRNA 3' ends

10

Dominique Gagliardi CNRS-University of Strasbourg, France

12:05 - 12:30 Non-coding RNAs and mRNAs: Brothers separated at birth?

11

David TollerveyUniversity of Edinburgh, United Kingdom

12:30 - 12:45 d4E-T: a eIF4E-binding protein that promotes deadenylation-dependent decay of target mRNAs to control cell proliferation

12

Cátia Igreja MPI for Developmental Biology Tuebingen, Germany

12:45 - 13:10 Virus-Host Interplay Leads to Widespread mRNA Destruction

13

Britt GlaunsingerUniversity of California Berkeley, United States of America

13:10 - 16:00 LUNCH and POSTER SESSION 1 ATC Foyer and Helices A & B

16:00 - 19:20 SESSION 3 - Mechanics and Regulation of Translation Chair: Karsten Weis, University of California, Berkeley, USA

ATC Auditorium

16:00 - 16:25 mRNA surveillance is driven by translation 14Rachel Green Johns Hopkins University School of Medicine, United States of America

16:25 - 16:40 CLIP-seq of the DEAD-box RNA helicase eIF4AIII reveals transcriptome-wide mapping of the exon junction complex in human

15

Herve Le Hir IBENS, France

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16:40 - 17:05 RNA meets metabolism: from mRNA interactomes to REM networks

16

Matthias Hentze European Molecular Biology Laboratory (EMBL), Germany

17:05 - 17:35 COFFEE BREAKATC Foyer

17:35 - 18:00 Molecular mechanisms of ribosomal scanning and AUG selection: where to begin?

17

Alan Hinnebusch National Institutes of Health, United States of America

18:00 - 18:15 The cryo-EM structure of the UPF-EJC complex shows how UPF1 is poised to unwind the 3' end of a PTC-containing mRNP

18

Oscar Llorca Spanish National Research Council-CSIC, Spain

18:15 - 18:40 Translational Control of Higher Brain Function 19Joel Richter University of Massachusetts Medical School, United States of America

18:40 - 18:55 Physiological Role of NMD in Neuronal Development In Vivo

20

Eleen Shum UC San Diego, United States of America

18:55 - 19:20 Crystal structures of the eukaryotic ribosome and insights into the regulation and initiation of protein synthesis

21

Nenad Ban

ETH Zurich, Switzerland

19:20 - 21:00 DINNER EMBL Canteen

21:00 - 23:00 Drinks in the ATC Foyer and Roof Top Lounge and poster viewing

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Programme

Tuesday 09 October 2012 09:00 - 12:40 SESSION 4 - Epigenetics and Transcription

Chair: Lynne Elizabeth Maquat, University of Rochester, USA

ATC Auditorium

09:00 - 09:25 Structure-guided dynamic transcriptome analysis elucidates the mRNA life cycle

22

Patrick Cramer Gene Center - LMU, Germany

09:25 - 09:40 Road-block termination defines a new class of cryptic transcripts

23

Domenico Libri CNRS - CGM, France

09:40 - 10:05 Chromatin and transcription regulate alternative splicing 24

Alberto Kornblihtt

FCEN, University of Buenos Aires and IFIBYNE-CONICET, Argentina

10:05 - 10:20 “Catching up” with polymerase: the mechanisms of Sen1-dependent termination

25

Odil Porrua Fuerte Centre de Genetique Moleculaire-CNRS, France

10:20 - 10:35 The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts

26

Markus Landthaler Max-Delbrück-Center for Molecular Medicine, Germany


11:05 - 11:30 Ending the message in eukaryotes: Gene loops, R-loops and noncoding RNA

27

Nicholas Proudfoot University of Oxford, United Kingdom

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11:30 - 11:45 Global regulatory functions of Sen1-dependent Pol II termination factors

28

David Brow University of Wisconsin-Madison, United States of America

11:45 - 12:10 Splicing on chromatin 29Karla NeugebauerMPI-CBG, Germany

12:10 - 12:25 Single cell analysis reveals aspects of antisense RNA regulation and mode of action in PHO84 transcription repression

30

Daniel Zenklusen Université de Montréal, Canada

12:25 - 12:40 Genome-wide measurement of RNA structure in vivo 31Silvia Rouskin UCSF, United States of America


15:30 - 17:40 SESSION 5 - Pre-mRNA ProcessingChair: Alberto Kornblihtt, University of Buenos Aires, Argentina ATC Auditorium

15:30 - 15:55 Processing of mRNA precursors and links to human disease

32

James Manley Columbia University, United States of America

15:55 - 16:20 TELESCRIPTING: A New Dimension to mRNA Regulation 33

Gideon Dreyfuss

HHMI/University of Pennsylvania School of Medicine, United States of America

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Programme

16:20 - 16:35 ELAV mediates neuronal-specific 3’ UTR extension by suppressing proximal polyadenylation

34

Valerie Hilgers UC Berkeley, United States of America

16:35 - 17:00 How competition between RNA-binding proteins for overlapping binding sites controls splicing decisions

35

Jernej Ule

MRC Laboratory of Molecular Biology, United Kingdom

17:00 - 17:15 CWC22 Connects Pre-mRNA Splicing and Exon Junction Complex Assembly

36

Anna-Lena SteckelbergInstitute for Genetics, University of Cologne, Germany

17:15 - 17:40 Pre-mRNA processing and mRNA metabolism 37Melissa Moore HHMI/University of Massachusetts Medical School, United States of America

17:40 - 18:00 Pre-dinner drinks ATC Foyer

18:00 - 20:00 DINNER EMBL Canteen

20:00 - 23:00 Drinks in the ATC Foyer and Roof Top Lounge and poster viewing

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Wednesday 10 October 2012 09:00 - 12:35 SESSION 6 - miRNA Function

Chair: Matthias W. Hentze, EMBL Heidelberg, Germany

ATC Auditorium

09:00 - 09:25 Structural insights into miRISC recruitment of the CCR4-NOT complex

38

Nahum Sonenberg McGill University, Canada

09:25 - 09:50 Function and Regulation of MicroRNAs 39Helge GrosshansFMI, Switzerland

09:50 - 10:05 The piRNA pathway and its role in the regulation of maternal mRNAs in the Drosophila early embryo

40

Bridlin BarckmannIGH Institute of Human Genetics, France

10:05 - 10:30 Regulation of miRNA-mediated Repression and miRNA Metabolism in Mammalian Cells

41

Witold Filipowicz Friedrich Miescher Institute for Biomedical Research, Switzerland


11:00 - 11:25 Biogenesis and function of PIWI-interacting RNA in Drosophila

42

Mikiko Siomi Graduate School of Science, University of Tokyo, Japan

11:25 - 11:40 miRNA-mediated regulation of the cyrano lincRNA is a non-canonical pathway essential for early vertebrate development

43

Alena Shkumatava Whitehead Institute/MIT, United States of America

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Programme

11:40 - 12:05 Evolutionary plasticity of the protein interaction network that regulates mRNA stability

44

Elisa Izaurralde Max Planck Institute for Developmental Biology, Germany

12:05 - 12:20 Structure of yeast Argonaute with guide RNA 45David WeinbergWhitehead Institute / MIT, United States of America

12:20 - 12:35 The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis

46

Astrid Haase Cold Spring Harbor Laboratory, United States of America


15:30 - 18:30 SESSION 7 - mRNA Export and Localization Chair: Melissa J. Moore, UMass Medical School/HHMI, USA

ATC Auditorium

15:30 - 15:55 Regulation of mRNA export and decay 47Karsten Weis UC Berkeley, United States of America

15:55 - 16:10 Blastomere-specific transcriptome profiling after the first embryonic division

48

Erin Osborne Nishimura University of North Carolina, United States of America

16:10 - 16:25 Structural studies of a minimal eIF4E-Cup complex 49Fulvia Bono Max Planck for Developmental Biology, Germany


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16:55 - 17:10 The Unfolded Protein Response in Fission Yeast Modulates Stability of Select mRNAs to Maintain Protein Homeostasis

50

Philipp Kimmig UCSF, United States of America

17:10 - 17:25 Insights into biogenesis and localization of mRNPs from in vitro reconstitution experiments

51

Dierk Niessing Helmholtz Zentrum München, Germany

17:25 - 17:50 Adaptation of the organism to its environment: fine-tuning RNA localization dynamics

52

Anne Ephrussi EMBL Heidelberg, Germany

17:50 - 18:15 Following Single mRNAs from Birth to Death: A Systems Approach

53

Robert Singer Albert Einstein College of Medicine, United States of America

18:15 - 18:30 Closing remarks ATC Auditorium

18:30 - 00:00 BANQUET DINNER and PARTY EMBL Canteen and ATC Foyer

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Posters A-Z

Adeli, Khosrow Translational Control of Apolipoprotein B mRNA via miRNAs and Localization in RNA Granules

54

Ahmad, Mohd Hafiz Analysis of mirna Transcriptome in Normal Peripheral Blood Mononuclear Cells, Chronic Myeloid Leukemia and K562 Cells

55

Allain, Frédéric Recognition of let-7 miRNA by the zinc knuckles of Lin28 56

Allmang, Christine The cap of selenoprotein mRNAs is hypermethylated : similarities with snRNA processing

57

Antic, Sanja Ribosome association of the mRNA degradation machinery and the miRNA effector complex in Drosophila cells

58

Aregger, Michael Cell-cycle-dependent phosphorylation of the RNA cap methyltransferaseis required for cell proliferation

59

Arnold, Andreas Investigating the function of Y-box binding proteins in C. elegans 60

Arribas, Laura The biological role of slicing for Arabidopsis Argonaute1 61

Asta, Francesco RUMP, a Drosophila hnRNP M homolog, elicits decay of mRNA targets 62

Attig, Jan The TIA/TIAL proteins regulate alternative polyA-site choice and thereby mRNA isoform expression

63

Babic, Ana Transcriptome profiling at the synapse 64

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Barbosa, Cristina An upstream open reading frame regulates the translational efficiency of the human erythropoietin transcript

65

Bawankar, PraveenNOT10 and C2orf29 form a metazoan-specific module of the CCR4–NOT complex that docks onto the N-terminal domain of NOT1

66

Beckmann, Benedikt M. RNA-binding proteins in posttranscriptional control: defining a eukaryoticcore mRNA interactome

67

Béthune, Julien L. Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells

68

Bezzi, Marco PRMT5 links alternative splicing and apoptosis in mammalian brain development

69

Bhattacharyya, Suvendra N. Leishmania donovani downregulates miR-122 in Liver to Modulate Serum Cholesterol in Parasite Infected Mouse: Mechanism and Beyond

70

Bieniossek, Christoph Crafting TFIID: TAF8/TAF10 complex accretion breaks symmetry in human TFIID coactivator core structure

71

Blazquez, Lorea Inhibition of gene expression by combining RNA interference and U1 inhibition

72

Bo Eng, Cheong Molecular Cloning of Chalcone Synthase Gene from the Leaves of Strobilanthes crispus

73

Bohmer, Marc Indian Hedgehog Signalling is regulated by the miR-15/16/195/424/497 family

74

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Posters A-Z

Bohne, Jens U1snRNP-mediated poly(A) site suppression is the molecular basis of a complex immunodeficiency

75

Bojarska, ElzbietaSubstrate specificity of yeast scavenger decapping enzyme (Dcs1) for dinucleotide cap analogs

76

Bratu, Diana P. Loss of RNAi protein Armitage in the germline vs. soma delineates its requirement during Drosophila melanogaster oocyte development

77

Brümmer, Anneke Modeling the binding specificity of RNA-binding proteins: the case of GLD-1

78

Büttner, Lisa Imaging the nuclear trafficking and export of single ribosomes in vivo 79

Cano, Florencia RNA-binding E3 ubiquitin ligases regulate mRNA decay 80

Carmo Fonseca, Maria Non productive spliceosome assembly is sufficient to export unspliced RNA to the cytoplasm

81

Carré, Clément An automiG biosensor identifies chemical compounds that inhibit miRNAbiogenesis or Argonaute-2 mediated silencing

82

Carré, Clément Human GTPases associate with RNA polymerase II to mediate its nuclear import

83

Chen, Hung-Ta Site-specific mapping of Brf1 within the RNA polymerase III pre-initiation complex

84

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Chen, Ying Crystal Structure and Heterodimerization of the NOT Box Domains of human NOT2 and NOT3

85

Chereda, Bradley Characterisation of the BCR-ABL 3’untranslated region 86

Ciminale, Vincenzo Expression kinetics and intracellular compartmentalization of HTLV-1 alternatively spliced mRNAs

87

Clayton, Christine E. An ARE-binding protein as post-transcriptional regulator of the trypanosome heat-shock response

88

Cleary, Michael Identification of mRNA decay networks in the Drosophila nervous system 89

Cook, Atlanta G. NF45 interacts with NF90, SPNR and Zfr via a conserved nucleotidyltransferase fold

90

Cosson, Bertrand Combining analyses of 3-D structure and phylogeny reveals a new partner of eIF4E

91

Costello, Joe A role for Puf3 in translational control following oxidative stress 92

Dallacqua, RodrigoDifferentially expressed genes in honey bee queen ovaries during metamorphosis

93

Dargemont, Catherine mRNA journey from transcription to the nuclear pore complex: Focus on histone marks and ubiquitin modifications

94

de Lucas, SusanaDeep-sequencing of RNAs associated to hStaufen 1 complexes identifies conserved sequences involved in RNA-protein interaction

95

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Posters A-Z

de Moor, Cornelia H. The role of poly(A) tail metabolism in immediate early gene expression 96

De Vito, FrancescaCanonical and non-canonical regulation of c-jun transcript by miR-200 family members

97

Deneke, Carlus Linking the biochemistry of mRNA degradation to mRNA decay experiments: Insights from mathematical modeling

98

Despic, Vladimir Study of pre-mRNA splicing during early zebrafish embryogenesis 99

Dhamija, Sonam Translational activation contributes to induction of the negative regulator of inflammation, MCPIP1, by IL-1 and IL-17

100

Diamant, Gil DSIF Restricts NF- κB Signaling by Coordinating Elongation with mRNA Processing of Negative Feedback Genes

101

Dikfidan, Aytac Structural and functional characterization of the polynucleotide kinase Clp1

102

Dimitrova, Lyudmila In vitro assembly of TRanscription-EXport complex 2 (TREX-2) from Chaetomium thermophilum

103

Dominissini, Dan Topology of the human and mouse m6A RNA methylomes 104

Donato Tanaka, Erica Multiple roles of miR-306 in honeybee Apis mellifera physiology and reproduction

105

Duarte Pereira, Sara Characterization of NAPRT1 alternative transcripts 106

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Dueck, Anne microRNAs associated with the different human Argonaute proteins 107

Duszczyk, Malgorzata Dead End, a protein counteracting miRNA-mediated repression of tumour suppressor genes, contains non-canonical RNA binding domains

108

Dutertre, Martin Genome-wide analysis reveals specific patterns of alternative last exon regulation by genotoxic anticancer agents

109

Dziembowski, Andrzej The central channel controls both exonuclease and endonuclease activities of the exosome complex both in vivo and in vitro

110

Elek, Zsuzsanna Polymorphisms in regulatory regions of the WFS1 gene are putative risk factors of diabetes mellitus

111

Erben, Esteban Post-transcriptional control in trypanosomatids: identification of the mRNA fate modulators through a high-throughput tethering assay

112

Fareh, Mohamed The microvesicles enclosing the cluster miR-302-367 compromise tumorigenic proprieties of Glioma Initiating Cells

113

Fei, Jingyi Organization of long non-coding RNAs in nuclear bodies revealed by super resolution imaging

114

Feldbrugge, Michael Microtubule-dependent co-transport of mRNPs and endosomes in the model microorganism Ustilago maydis

115

Fontrodona, Laura Caenorhabditis elegans to address the autosomal dominant Retinitis Pigmentosa paradox for splicing related genes

116

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Posters A-Z

Fromm, Simon A. The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex

117

Gahura, Ondrej First splicing step in Saccharomyces cerevisiae requires Prp45 118

Galeano, Federica ADAR2 editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis

119

Garmendia, Cecilia Asymmetric localization of p-bodies during the yeast cell cycle 120

Gavaldá, Sandra A new link between mRNA surveillance and genome instability mediated by Trf4

121

Glória, Vânia At the crossroads between transcription and splicing regulation of CD6 exon 5 alternative splicing

122

Goebels, Carolin Analysis of the role of introns on gene expression in Cryptococcus neoformans

123

Göhring, Janett In Vivo Imaging of Endogenous RNA Variants in Plant Cells 124

Gonatopoulos Pournatzis, Thomas RAM: A Novel and Essential Component of the mRNA Cap Methylation Machinery

125

Gonzàlez-Porta, Mar Genome-wide characterization of transcript isoform predominance 126

Gorgoni, Barbara Mechanism of DAZL-mediated translational regulation during germ cell development

127

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Graille, Marc RNA quality control pathways dedicated to the release of ribosomes stalled in translation

128

Graindorge, Antoine Held-Out-Wings (HOW) acts as a SXL co-repressor in msl2 mRNA regulation

129

Gray, Nicola K. Extensive and complex post-translational modification of poly(A)-binding protein (PABP) 1 may regulate its multi-functionality

130

Gregersen, Lea Haarup Transcriptome-wide analysis of the RNA binding pattern of the RNA helicase MOV10

131

Gribling-Burrer, Anne-Sophie Assembly of selenoprotein mRNPs: potential role of the Survival of MotorNeurons (SMN) and methylosome complexes involved in sn(o)RNP biogenesis

132

Grosswendt, Stefanie Transcriptome-wide identification of miRNA binding sites in C. elegans 133

Gruber, Andreas R. Cleavage Factor Im as a key regulator of 3’ UTR length 134

Grund, Kerstin Stress-dependent 3’end processing regulates the expression of two key proteases for coagulation, F2 and Urokinase

135

Grzybowska, Ewa New insight into HAX-1 functions: nucleocytoplasmic shuttling, involvement in mRNA processing, nuclear export and P-body localization

136

Guidugli Lazzarini, Karina Rosa Gene expression profiles associated with behavioral maturation of Apis mellifera workers

137

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Posters A-Z

Guimarães, Beatriz Gomes Activity of Trypanosoma brucei exosome component Rrp6 and its partner EAP3 towards different RNA substrates

138

Hafner, Markus Nucleocytoplasmic transport of mRNAs by Exportin 5 139

Hallegger, Martina miRNA profile of Dopamine neurons derived from induced pluripotent stem cells

140

Hammarskjold, Marie-Louise A conserved mechanism for expression of proteins from mRNAs with retained introns

141

Handler, Dominik Idenification of novel piRNA factors by an tissue specific transcriptome wide RNAi screen in Drosophila melanogaster

142

Hashimoto, Yoshifumi Translation termination factor eRF3 is targeted for caspase-mediated proteolytic cleavage and degradation during DNA damage-induced apoptosis

143

Hausser, Jean Integration of low- and high-throughput data sets reveals the kinetics of miRNA-dependent gene regulation

144

Helwak, Aleksandra Mapping the human miRNA interactome by CLASH reveals frequent non-canonical binding

145

Heras, Sara R. The Microprocessor controls the activity of mammalian LINE-1 retrotransposon

146

Hermesh, Orit The link of mRNA localization to the ER 147

Hett, Anne Studying the fate of aberrantly spliced human pre-mRNAs 148

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Hlevnjak, Mario Structural and functional enrichment analysis of the distribution of mRNApyrimidine content versus protein polar requirement sequence profiles

149

Hofmann, Ilse (Presenter: Regina Fischer-Keso)Plakophilin 3 regulates the mRNA stability of plakophilin 2 150

Holmes, Rebecca K. Crosslinking reveals unexpected roles for the yeast SR protein Npl3 in RNA metabolism

151

Hornyik, Csaba Exploring the miRNA transcriptome of a tuber bearing crop, potato 152

Horos, Rastislav Dynamic responses of the hepatocytic mRNA interactome to metabolic reprogramming

153

Jalinot, Pierre Role of INT6/EIF3E in histone mRNA translation 154

Jambor, Helena A systematic exploration of RNA localization in Drosophila ovaries: Finding novel partners of the maternal determinants

155

Jonas, Stefanie Structural insight into the role of SMG5–SMG7 heterodimerization for nonsense-mediated mRNA decay

156

Joo, Chirlmin Single-Molecule Approach to MicroRNA Protein Complexes 157

Jopling, Catherine L. Transcription, splicing and processing of exonic microRNAs 158

Juli, Giada Inhibition of translation elongation in response to ribosomal stress 159

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Posters A-Z

Kaminski, Tim Regulation of RNAP II during stable elongation under induced stress 160

Karousis, Evangelos D. A rapid and straightforward approach for the isolation, cloning and expression analysis of subtle alternative transcript isoforms

161

Kellner, Julian NMStructure – Function studies of the RNA helicase DDX1 162

Kershaw, Chris The La-motif containing protein Slf1 is involved in the translation regulation of mRNAs destined for mitochondria

163

Kesarwani, Anil K. Feedback and salt stress regulation of nonsense-mediated decay factorsin Arabidopsis

164

Kim, Hajin Dynamics of the Mitochondrial Transcription Pre-Initiation Complex 165

Kim, Tae Don Human microRNA-27a* targets Prf1 and GzmB expression to regulate NK cell cytotoxicity

166

Klinge, Sebastian Crystal Structure of the Eukaryotic 60S Ribosomal Subunit in Complex with Initiation Factor 6

167

Köhn, Marcel The non-coding Y3-RNA promotes histone-mRNA 3'-processing 168

Kolowerzo, Agnieszka Functional analysis of poly(A) RNA present in Cajal bodies 169

Kong, Ka-Yiu Edwin Yeast TRAMP complex facilitates splicing factor recruitment and contributes to optimal splicing efficiency

170

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Kramer, Susanne Simpler P-bodies? Insights into RNA granules formation in trypanosomes.

171

Kubitscheck, UlrichNuclear Export of single native mRNA 172

Kuhlmann, Sonja Structural basis for the molecular recognition of polyadenosine RNA by the Zn fingers of Nab2

173

Kumakura, Naoyoshi Assessment of plant RNA exosome as a viral resistance factor 174

Lanctôt, Christian Transcriptional pulsing of RNA polymerase I-dependent transgene expression in living cells

175

Lange, Sita J. Global or local? Predicting secondary structure and accessibility in mRNAs

176

Larivière, Laurent Structure of the Mediator head module 177

Lazzaretti, Daniela Structural and functional characterization of eIF1A nuclear export pathway

178

Le Gallic, Lionel Altered metabolism in Psoriasis leads to HuR mediated stabilization of selective mRNAs

179

Limousin, Taran miRNAs can inhibit translation initiation independently of PABP/eIF4G interaction

180

Linero, Florencia Natalia Translational strategy of New World arenavirus: The viral nucleoprotein as a translation initiation factor

181

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Posters A-Z

Lloyd, James PB SMG1 is an ancient nonsense-mediated mRNA decay effector that has been lost from multiple lineages

182

Löber, Jana Regulation of Nonsense-Mediated mRNA Decay by Cellular Stress 183

Loedige, Inga The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function

184

Longman, Dasa DHX34 and NAG/NBAS act in concert with core NMD factors to regulatecommon endogenous RNA targets in humans, zebrafish and C. elegans

185

Lyons, Shawn M. The C-terminal tail of Lsm4 is required for efficient histone mRNA degradation

186

Mackereth, Cameron D. Nucleic-acid binding by splicing factor Sup-12 and isoform control in nematode muscle

187

Magler, Iris Crystal structures of the Cid1 poly (U) polymerase reveal the mechanism for UTP selectivity

188

Majewska, Aneta Differences in expression of inflammatory genes (Tnfa and Mcp-1) and their histone H3 acetylation in the liver of young and old hyperphagic obese mice

189

Makino, Debora L.The Crystal Structure of a Yeast 11-Subunit Exosome Complex Bound toRNA

190

Manojlovic, Zarko Translation regulation of type I collagen mRNAs; a silent mechanism of fibrogenesis

191

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Martinho, Rui G. Defining the requirements for efficient gene expression during early embryonic development

192

Maryan, Natalia Lack of evidence for transcriptional ripple effect in the neighbourhood of mitogen activated genes

193

Maslovskaja, JuliaAIRE-regulated gene expression mainly occurs on transcriptional level and is promoter-independent

194

Mathys, HansruediMultitude of protein sequence elements and protein-protein interactions involved in miRNA-mediated repression in metazoa

195

Mattioli, Chiara Antagonistic role of spliceosome and microprocessor complex on processing of Splice site Overlapping (SO) pri-miRNAs

196

Mauxion, Fabienne H. The conserved C2ORF29 protein is a bona fide subunit of the CCR4-NOT complex

197

Meignin, Carine Sensing viral RNAs by the innate immune system in drosophila 198

Meinel, Dominik Cotranscriptional recruitment of mRNA export adaptors to genes: a genome-wide view

199

Mercier, Blandine Translation-dependent mRNA decay: a key regulator of gene expression in T cells?

200

Michaud, MorganeCytosolic mRNA trafficking to plant mitochondria 201

Mikl, Martin The mRNA splicing regulator SPK-1 is required for cell polarity in one-cellC. elegans embryos

202

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Posters A-Z

Militti, Cristina Drosophila UNR regulates dosage compensation complex assembly by acting as an RNA chaperone on roX2 noncoding RNA

203

Mircsof, Dennis The Role of NOPS proteins in regulating inhibitory synapse function 204

Mocquet, Vincent HTLV-1 Tax protein inhibits NMD by interacting with INT6/EIF3E and UPF1

205

Moda, Livia Maria Differential nutrition, mRNA expression and brain mophogenesis: the honeybee model

206

Modic, Miha The role of TDP-43 in Controlling the Selection of Alternative Polyadenylation Sites

207

Morales, Julia Translational control during sea urchin early development 208

Moran, Yehu The roles and mode of action of microRNAs in the sea anemone Nematostella vectensis

209

Moreira, Alex Gene Punctuation: alternative polyadenylation and transcription termination between closely spaced tandem genes

210

Mrvova, Silvia Acute lymphoblastic leukaemia cell lines have downregulated expressionof eIF3b

211

Müller-McNicoll, Michaela Novel roles for SR proteins in histone mRNA expression 212

Munschauer, Mathias Protein occupancy profiling globally maps putative cis-regulatory mRNA regions

213

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Muthukrishnan, Anantha Barathi Plasticity of in vivo RNA production under the control of tetA promoter inindividual Escherichia coli cells

214

Nicholson, PamelaUnravelling the mammalian nonsense-mediated mRNA decay pathway by a combined tethering / knockdown approach

215

Niedzwiecka, AnnaBiophysical properties of full length human 5’-dependent 3’-poly(A)-specific ribonuclease (PARN)

216

Nishihara, TadashimiRNA-mediated recruitment of decapping factors to mRNA targets 217

Obermann, Diana A novel role for CELF1 in vegetal RNA localization during Xenopus laevis oogenesis

218

Ogami, Koichi Anti-proliferative protein Tob directly regulates c-myc proto-oncogene expression through cytoplasmic polyadenylation element-binding proteinCPEB

219

Onofre, Cláudia Translational control of the human hemojuvelin via upstream open reading frames

220

Pagani, Franco Molecular mechanism underlying splicing correction mediated by Exon-Specific U1 snRNAs (ExSpeU1)

221

Pascual, Malena Repression at Smaug 1 mRNA silencing foci involves the miRNA pathway

222

Passos, Geraldo A.The messenger RNAs that code peripheral tissue antigens in the thymusare under two levels of control involving Aire and then microRNAs

223

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Posters A-Z

Pauli, Andrea Coding potential of the transcriptome during zebrafish embryogenesis 224

Petz, Michaela PDGF mediated regulation of IRES driven Laminin B1 expression during cancer invasion

225

Pimentel, CatarinaTranscriptional and post-transcriptional mechanisms controlling iron storage in yeast

226

Pires, Camilla Valente Transcriptome analysis of Apis mellifera haploid embryos males 227

Plotnikova, Aleksandra The decapping activator HPat a novel factor interacting with the miRNA effector complex

228

Polyansky, Anton A. Evidence for the stereo-chemical origins of the genetic code and direct complementary interactions between proteins and cognate mRNAs obtained from the analysis of protein-RNA complexes

229

Provenzani, Alessandro The RNA binding protein HuR is involved in the insurgence of drug resistance mechanism to doxorubicin in breast cancer cells.

230

Quintas, Ana Deciphering the RNA-binding mechanism of African swine fever virus g5R protein

231

Ramundo, Silvia Conditional repression of plastid gene expression reveals the complex life of some mRNAs in the chloroplast

232

Rashpa, Ravish Elucidating the role of Cap binding proteins in BicD dependent localization processes

233

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Rayson, Samantha Conserved peptide upstream open reading frames as targets of nonsense-mediated mRNA decay

234

Ribas, Lluís (Presenter: Eva Novoa) A new mechanism for genome-wide control of gene expression levels 235

Rodriguez-Navarro, Susana TREX-2 mRNA export complex and SAGA dependent deubiquitylation 236

Rösel, Tanja U1C-dependent alternative splicing regulation: RNA-Seq analysis revealsU1C/U1-70K cross-regulation

237

Rota, Rossella Notch3-dependent myomiRs regulation in Rhabdomyosarcoma 238

Roudko, Vladimir Recruitment of Ccr4-Caf1 to the Not complex is required for efficient mRNA deadenylation in vivo

239

Roux, Milena The role of Arabidopsis PAT1 in plant innate immunity 240

Roy, Rahul Spatial organization of RNA polymerase II and spliceosome revealed by super-resolution imaging of mammalian cell nucleus

241

Rybak, AgnieszkaIn vivo Dicer targets 242

Sakakibara, Iori The Six1-Linc-MYH axis regulates muscle fiber phenotype 243

Sato, Ryosuke Analyses of underlying relationship between the subcellular localization and stimulatory activity on cap-dependent translation of RNA-binding protein HuD

244

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Posters A-Z

Savelyeva, Anna Transfection of human cells by artificial RNA-nucleophosmin 1 complexes

245

Sawh, Ahilya N. A Truncated Dicer Tilts the Balance of RNAi Pathways 246

Schaal, Heiner U1 in tug of war: The choice between two closely spaced, identical splice sites is controlled by outside-positioned splicing regulatory elements

247

Schamberger, Anita Experimental validation of human mirtrons: functional microRNAs can beproduced simultaneously from both arms in a flanking exon-independentmanner

248

Scheiffele, Peter Dynamic regulation of synaptic adhesion complexes by alternative splicing

249

Scherrer, Klaus The Gene and Genon Concept allows Functional and Information-theoretic Analysis of Gene Expression

250

Schmid, Tobias Inflammatory conditions induce IRES-dependent translation of cyp24A1 251

Schüler, Markus Analyzing transcriptome-wide protein occupancy profiling 252

Schüler, Markus doRiNA: A database of RNA interactions in post-transcriptional regulation

253

Schwartz, Schraga Exploring the 5th base of mRNA: Transcriptome wide mapping of the mamalian N6-methyladenosine landscape

254

Schwarz, Juliane A System Analysis of Translation in Stem Cells 255

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Seibt, Julie Sleep-dependent mRNA translation consolidates cortical plasticity in vivo

256

Sellier, Chantal Fox proteins chase MBNL1 from CCUG aggregates: an explanation to the lesser severity of DM2 ?

257

Serpeloni, MarianamRNA transcription/export pathway in parasites: are they using the same way?

258

Sesma, Ane RBP35 is a novel auxiliary protein of the polyadenylation machinery of filamentous fungi

259

Shahbabian, Karen Coordinated assembly of localization and translational control factors on mRNA during transcription

260

Shalem, Ophir H. Measurements of the impact of 3' end sequences on gene expression reveal wide range and sequence dependent effects

261

Shao, Ada An NMD-microRNA Regulatory Circuit in the Brain 262

Sharbati, Soroush Intestinal Salmonella Typhimurium infection leads to miR-29a induced Caveolin 2 regulation

263

Sharma, Varun Kumar The microRNA regulatory network in T-cells transformed by human T-cellleukemia virus type 1

264

Shcherbata, Halyna Drosophila microRNA-9a canalizes the process of muscle attachment assembly via downregulation of Dystroglycan

265

Shcherbata, Halyna The miR-310s complex regulates cell differentiation and proliferation in Drosophila

266

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Posters A-Z

Shcherbata, Halyna R. Steroid-induced microRNA let-7 acts as a spatio-temporal code for neuronal cell fate in the developing Drosophila brain

267

Siebrasse, Jan-Peter Single Molecule Kinetics of the RNA Helicase Dbp5 268

Singh, Kusum K. Two functional MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay

269

Singhania, Richa Post-transcriptional and translational control of siRNA-generated mRNA cleavage fragments

270

Slobodin, Boris The COPI coat complex and two cis-acting motifs govern the intracellular localization of OXA1 mRNA and its contribution to mitochondrial function

271

Smolinski, Dariusz J. Correlation between mRNA metabolism and formation of Cajal bodies and cytoplasmic snRNP-rich bodies

272

Sperling, Joseph Genome-wide activation of latent donor splice sites in stress and disease 273

Sperling, Ruth A network of interactions within the supraspliceosome 274

Spiró, Zoltán Characterization of lin-5 mRNA localization in C. elegans embryos 275

Stepanov, Grigoriy Artificial Box C/D RNAs Affect pre-mRNA Maturation in Human Cells 276

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Stevens, Stewart G. Translation efficiency in human cells – the poor correlation between mRNA and protein levels for many genes indicates widespread translational control

277

Stöhr, Nadine IGF2BP1 - A post-transcriptional ‘driver’ of tumor cell migration 278

Sträßer, Katja The phosphoproteome of ribosomes and two specific roles in translation 279

Subasic, Deni A switch in microRNA target regulation in C. elegans: from translational inhibition to mRNA degradation in miR-58 family mutants

280

Sugiyama, Tomoyasu Selective Elimination of Meiotic mRNAs in Vegetative Fission Yeast 281

Sun, Mai Comparative Dynamic Transcriptome Analysis (cDTA) reveals mutual feedback between mRNA synthesis and degradation

282

Susor, Andrej EJC component Magoh, is essential for processing of specific transcripts in the mammalian oocyte

283

Swida-Barteczka, Aleksandra Plant miRNAs originated from the 3’UTR of protein coding genes 284

Syntichaki, Popi The role of mRNA metabolism factors in the lifespan and stress responseof Caenorhabditis elegans

285

Takeuchi-Tomita, Nono Role of the N-terminal extension on the activity of mammalian mitochondrial ribosome recycling factor: implication for the role of GTP-hydrolysis in ribosome recycling

286

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Posters A-Z

Tamura, Teruko Interaction of THOC5, a member of mRNA export complex with its targetmRNA: CA/UG trinucleotide repeats directly bind to putative helical structure domain of THOC5

287

Tantale, Katjana HIV-1 transcription in live cells with single polymerase sensitivity 288

Tantale, Katjana 3’end cleavage buffers transcriptional noise 289

Tatomer, Deirdre C. Mutation of flash affects both histone locus body structure and histone pre-mRNA processing: separation of function mutations define regions required for discrete roles

290

Tebaldi, Toma Triomics: comparison between transcriptome, translatome and proteome variations

291

Teoh, Peik Lin The WAR complex controls the efficiency of FOS splicing 292

Theil, Kathrin 5' UTR-mediated translational repression by the RNA binding protein GLD-1

293

Tiedje, Christopher The p38/MK2-driven exchange of TTP by HuR regulates LPS-induced translation initiation of AU-rich element containing mRNAs

294

Tomasetto, Catherine L. Perispeckles are major assembly sites for the exon junction core complex

295

Tran, Doan Duy Hai THOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for M-CSF induced macrophage differentiation, thereby playing a key role in the mRNA export of M-CSF inducible genes

296

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Twyffels, Laure Competitive interplay between the cytoplasmic role of dTIS11 in ARE-mediated decay and its Transportin-dependent nuclear import

297

Ubby, Ifeoma Regulation of TMEM16A Alternative Splicing 298

Urban, Marc Small RNA pathways in female gamete specification in Arabidopsis thaliana

299

Valasek, Leos Yeast Translation Begins and Ends with Translation Initiation Factor 3 (eIF3)

300

Vanacova, Stepanka A Phosphoserine-Proline Switch in RNAP II CTD Controls Binding of an RNA Processing Factor

301

Vindry, Caroline dTIS11-dependent polysomal deadenylation is the key step in AU-Rich Element-mediated mRNA decay in Drosophila cells

302

Vlatakis, Ioannis C.Enhancer of RNA interference -1-like-1: one more player in the RNA processing game of the chloroplast

303

Wagner, Jasmin Intracellular microRNA licalization and trafficking 304

Wang, Shao-Win Pdc1 functions in the assembly of P-bodies in Schizosaccharomyces pombe

305

Wang, Zhen Mapping the transcriptome-wide exon junction complex binding sites using 2-step iCLIP of eIF4A3

306

Weill, Laure Musashi: a new layer in the combinatorial CPE code 307

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Posters A-Z

Wellner, Juliane Germ cell specific RNA stabilization in Xenopus embryos 308

Winkler, Sebastiaan The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4 Not complex

309

Wippich, Frank DYRK3 couples mTORC1 signaling to mRNA granule turnover 310

Wong, Justin J-L An atlas of differential mRNA regulation by miRNAs in stem and committed myeloid cells

311

Wurth, Laurence A role of the conserved RNA-binding protein UNR in cancer progression 312

Zagrovic, Bojan Sequence Signatures of Direct Complementarity between mRNAs and Cognate Proteins on Multiple Levels

313

Zielonka, ElisabethResponses of mRNA interactome and RNA-regulons to genotoxic stress 314

Zirkel, Anne M. IGF2BP1 promotes mesenchymal cell properties by enhancing the LEF1-dependent expression of fibronectin

315

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