supplementary fig.1
DESCRIPTION
b. Relative expression ratio vs. pCMX. DAOY. Relative expression ratio vs. pCMX. D458 Med. Relative expression ratio vs. pCMX. Med8A. Stable overexpression. Supplementary Fig.1. a. Relative expression ratio vs. HKsRNAs. Native expression. c. Relative expression ratio vs. siCtrl. - PowerPoint PPT PresentationTRANSCRIPT
Supplementary Fig.1
0.02.04.06.08.0
10.012.014.0
DAOY D458Med
Med8A NCB
miR-182
miR-183
Native expression
Re
lativ
e e
xpre
ssio
nra
tio v
s. H
KsR
NA
sa
0
10
20
30
40
50
60
70
pCMX 182K1 182K2 183K1 183K2
Re
lativ
e e
xpre
ssio
nra
tio v
s. p
CM
X
DA
OY
Med
8AR
ela
tive
exp
ress
ion
ratio
vs.
pC
MX
Stable overexpression
b
0
20
40
60
80
100
120
140
pCMX 182K1 182K2 183K1 183K2
D45
8 M
ed
Re
lativ
e e
xpre
ssio
nra
tio v
s. p
CM
X
012345678
pCMX 182K1 182K2 183K1 183K2
Supplementary Fig.1
0.0
0.3
0.6
0.9
1.2
1.5
siCtrl si182 siCtrl si183
Re
lativ
e e
xpre
ssio
nra
tio v
s. s
iCtr
lR
ela
tive
exp
ress
ion
ratio
vs.
siC
trl
Transient knockdown
DA
OY
Med
8Ac
0.00.20.40.60.81.01.21.41.6
siCtrl si182 siCtrl si183
Re
lativ
e e
xpre
ssio
nra
tio v
s. s
iCtr
l
D45
8 M
ed
0.0
0.3
0.6
0.9
1.2
1.5
siCtrl si182 siCtrl si183
Supplementary Fig.2
Supplementary Fig.3
Molecular subgroup
miR-182 miR-183 miR-96
Supplementary Fig.4
Supplementary Fig. 5
Transient knockdown
0.5
1.0
1.5
2.0
2.5
3.0
3.5
1 2 3 4 5 6 7
DAOY-siCtrlDAOY-si183
DAOY-si182
0.5
1.0
1.5
2.0
2.5
3.0
1 2 3 4 5 6 7
M8A-siCtrl
M8A-si183
M8A-si182
Day
Me
tab
olic
act
ivity
, ra
tio v
s. D
ay1
Me
tab
olic
act
ivity
, ra
tio v
s. D
ay1
0.0
1.0
2.0
3.04.0
5.0
6.0
7.0
8.0
1 2 3 4 5 6 7
DAOY-pCMX
DAOY-183K1
DAOY-183K2
0.0
1.0
2.0
3.04.0
5.0
6.0
7.0
8.0
1 2 3 4 5 6 7
DAOY-pCMX
DAOY-182K1
DAOY-182K2
0.51.01.52.02.53.03.54.04.55.0
1 2 3 4 5 6 7
M8A-pCMXM8A-183K1M8A-183K2
0.51.01.52.02.53.03.54.04.55.0
1 2 3 4 5 6 7
M8A-pCMXM8A-182K1
M8A-182K2
Stable overexpression
Day Day
Me
tab
olic
act
ivity
, ra
tio v
s. D
ay1
Me
tab
olic
act
ivity
, ra
tio v
s. D
ay1
DA
OY
Med
8A
*
*
**
Supplementary Fig. 6