supplementary figure 1: representative sorting schematic ......calr_p.e379fs_50 tgaggtgtgtgctctgcct...
TRANSCRIPT
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Page 1 of 1
[Ungated]
FSC-A
0 100 200(x 103)
SSC-
A
0
100
200
(x 1
03)
[CD45+]
FSC-H
0 100 200(x 103)
FSC-
W
0
100
200
(x 1
03)
Singlet 1
[Singlet 2]
CD190 103 104 105
CD3
0
103
104
105
CD19+/CD3-
Representative FACS Schematic: CD5+/CD19+ CLL B cell Sort
[Ungated]
SSC-
A
0
100
200
(x 1
03)
Near IR Fixable Live Dead-A
0 103 104 105
Live
[Singlet 1]
SSC-H
0 100 200(x 103)
SSC-
W
0
100
200
(x 1
03)
Singlet 2
[CD19+/CD3-]
CD50 103 104 105
CD3
0
103
104
105
CD5+/CD19+/CD3-
[Ungated]
SSC-
A
0
100
200
(x 1
03)
CD45102 103 104 105
CD45+
Supplementary Figure 1: Representative sorting schematic for CLL leukemic B cells.
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Page 1 of 1
[Ungated]
FSC-A
0 100 200(x 103)
SSC-
A
0
100
200
(x 1
03)
[CD45+]
FSC-H
0 100 200(x 103)
FSC-
W
0
100
200
(x 1
03)
Singlet 1
[Singlet 2]
CD190 103 104 105
CD3
0
103
104
105
CD3+/CD19-
Gate %GatedAll 100.00CD3+/CD19- 99.64
Representative Purity: T-cell Sort
Sort Purity > 99.0%
[Ungated]
SSC-
A
0
100
200
(x 1
03)
Near IR Fixable Live Dead-A
0 103 104 105
Live
[Singlet 1]
SSC-H
0 100 200(x 103)
SSC-
W
0
100
200
(x 1
03)
Singlet 2
[Live]
SSC-
A
0
100
200
(x 1
03)
CD45102 103 104 105
CD45+
Supplementary Figure 2: Representative sorting purity check.
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Gene_Symbol Ion_AmpliSeq_Fwd_Primer Ion_AmpliSeq_Rev_Primer Chr Amplicon_Start Amplicon_StopCEBPA CCAGCCTGCCGTCCAGGTA GGCGGCATCTGCGAGCAC chr19 33792891 33793164CEBPA GCCTTGACCAAGGAGCTCTCT GACCTCCGCGCGAGTGG chr19 33792263 33792537CEBPA GGAGGCACCGGAATCTCCT GCTGGAGCTGACCAGTGAC chr19 33792119 33792379CEBPA GGGCTCCTGCTTGATCACC CGAGTTCCTGGCCGACCT chr19 33792829 33793096CEBPA GTTCTTGTCCACCGACTTCTTGG GCACCTGCAGTTCCAGATCG chr19 33792478 33792709CEBPA TGCAGGTGCATGGTGGTCT GGCTGGAGCCCCTGTACG chr19 33792659 33792896CEBPA GCAGGTGGCTGCTCATCG GAGGCCGCCTCGGACTCT chr19 33793263 33793511CEBPA GGGTCGATGTAGGCGCTGAT GGGAGAACTCTAACTCCCCCATG chr19 33793112 33793340FLT3_ITD CCAATCCACTCCATTTTTAGCCTTG AAAATGCACGTACTCACCATTTGT chr13 28607886 28608160FLT3_ITD TTCCATAAGCTGTTGCGTTCATCA TAGGTATGAAAGCCAGCTACAGATG chr13 28608072 28608346FLT3_ITD TTTTCTCTTGGAAACTCCCATTTGAGAT AACAATTGGTGTTTGTCTCCTCTTC chr13 28608230 28608504FLT3_ITD ACCTTTGCTTTTACCTTTTTGTACTTGT GGGAGTAGAGTATATGTAGAGTGGTTGT chr13 28608424 28608690KRAS_A146 GCCCTCTCAAGAGACAAAAACATTTAC TAGACACAAAACAGGCTCAGGACTTA chr12 25378405 25378624KRAS_K117 TAAGTCCTGAGCCTGTTTTGTGTCTA AAAAGTTGTGGACAGGTTTTGAAAGAT chr12 25378599 25378780KRAS_Q61 GTCCTCATGTACTGGTCCCTCATT AAAAGGTGCACTGTAATAATCCAGACT chr12 25380237 25380391KRAS_G12 GTACTCATGAAAATGGTCAGAGAAACCT ATTATAAGGCCTGCTGAAAATGACTGA chr12 25398122 25398337KRAS_G13 GTACTCATGAAAATGGTCAGAGAAACCT ATTATAAGGCCTGCTGAAAATGACTGA chr12 25398122 25398337PTPN11_A72 GTAACTCTTTATTTGTCCCCTTGCC CACAGTTCAGAGGATATTTAAGCTCAATG chr12 112888073 112888297PTPN11_D61fs_4 GTAACTCTTTATTTGTCCCCTTGCC CACAGTTCAGAGGATATTTAAGCTCAATG chr12 112888073 112888297PTPN11_D61 GTAACTCTTTATTTGTCCCCTTGCC CACAGTTCAGAGGATATTTAAGCTCAATG chr12 112888073 112888297PTPN11_E69 GTAACTCTTTATTTGTCCCCTTGCC CACAGTTCAGAGGATATTTAAGCTCAATG chr12 112888073 112888297PTPN11_E76 GTAACTCTTTATTTGTCCCCTTGCC CACAGTTCAGAGGATATTTAAGCTCAATG chr12 112888073 112888297PTPN11_G60 GTAACTCTTTATTTGTCCCCTTGCC CACAGTTCAGAGGATATTTAAGCTCAATG chr12 112888073 112888297PTPN11_N58 GTAACTCTTTATTTGTCCCCTTGCC CACAGTTCAGAGGATATTTAAGCTCAATG chr12 112888073 112888297PTPN11_G503 TTCATGATGTTTCCTTCGTAGGTGT GAGGCCTAGCAAGAGAATGAGAATC chr12 112926807 112927029PTPN11_P491 TTCATGATGTTTCCTTCGTAGGTGT GAGGCCTAGCAAGAGAATGAGAATC chr12 112926807 112927029PTPN11_Q510 TTCATGATGTTTCCTTCGTAGGTGT GAGGCCTAGCAAGAGAATGAGAATC chr12 112926807 112927029PTPN11_S502 TTCATGATGTTTCCTTCGTAGGTGT GAGGCCTAGCAAGAGAATGAGAATC chr12 112926807 112927029PTPN11_T507 TTCATGATGTTTCCTTCGTAGGTGT GAGGCCTAGCAAGAGAATGAGAATC chr12 112926807 112927029FLT3_D835Y AAATAAGTAGGAAATAGCAGCCTCACAT TGAGTCTAGAAGAAAGATTGCACTCC chr13 28592578 28592801IDH2_R140 GGACTAGGCGTGGGATGTTTTT AAGAATTTTAGGACCCCCGTCTG chr15 90631869 90632082IDH2_R172 GGGTGAAGACCATTTTGAAAGTGC AAAACATCCCACGCCTAGTCC chr15 90631677 90631889SRSF2_P95 CCCCTCAGCCCCGTTTAC GGAGTCCCGCGGCTTCG chr17 74732863 74733087CALR_p.A382fs_57 TGAGGTGTGTGCTCTGCCT TCTACAGCTCGTCCTTGGC chr19 13054504 13054728CALR_p.E364fs_46 TGAGGTGTGTGCTCTGCCT TCTACAGCTCGTCCTTGGC chr19 13054504 13054728CALR_p.E371fs_49 TGAGGTGTGTGCTCTGCCT TCTACAGCTCGTCCTTGGC chr19 13054504 13054728
Supplementary Table 1: AML Amplicons
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CALR_p.E379fs_50 TGAGGTGTGTGCTCTGCCT TCTACAGCTCGTCCTTGGC chr19 13054504 13054728CALR_p.E380fs_62 TGAGGTGTGTGCTCTGCCT TCTACAGCTCGTCCTTGGC chr19 13054504 13054728CALR_p.E386fs_46 TGAGGTGTGTGCTCTGCCT TCTACAGCTCGTCCTTGGC chr19 13054504 13054728CALR_p.E398_D400del TGAGGTGTGTGCTCTGCCT TCTACAGCTCGTCCTTGGC chr19 13054504 13054728CALR_p.E405_D408del TGAGGTGTGTGCTCTGCCT TCTACAGCTCGTCCTTGGC chr19 13054504 13054728CALR_p.K368fs_51 TGAGGTGTGTGCTCTGCCT TCTACAGCTCGTCCTTGGC chr19 13054504 13054728CALR_p.K374fs_56 TGAGGTGTGTGCTCTGCCT TCTACAGCTCGTCCTTGGC chr19 13054504 13054728CALR_p.K375fs_56 TGAGGTGTGTGCTCTGCCT TCTACAGCTCGTCCTTGGC chr19 13054504 13054728CALR_p.K377fs_54 TGAGGTGTGTGCTCTGCCT TCTACAGCTCGTCCTTGGC chr19 13054504 13054728CALR_p.K385fs_47 TGAGGTGTGTGCTCTGCCT TCTACAGCTCGTCCTTGGC chr19 13054504 13054728CALR_p.L367fs_46 TGAGGTGTGTGCTCTGCCT TCTACAGCTCGTCCTTGGC chr19 13054504 13054728CALR_p.R376fs_55 TGAGGTGTGTGCTCTGCCT TCTACAGCTCGTCCTTGGC chr19 13054504 13054728MPL_W515 AAGTCTGACCCTTTTTGTCTCCTAG GCGAACCAAGAATGCCTGTTTAC chr1 43814909 43815108DNMT3A_R882 TGTTTGTTTGTTTAACTTTGTGTCGCT GGTATTTGGTTTCCCAGTCCACTAT chr2 25457098 25457289SF3B1_K700 CTTCCATAAAGGCTTTAACACAGAATCA TCTGCAGTTTGGCTGAATAGTTGA chr2 198266733 198266957SF3B1_K666 TCAACTAAACTTCTAAGATGTGGCAAGA AGATAACATGGATGAGTATGTCCGTAAC chr2 198267294 198267506IDH1_R132 GCAAAATCACATTATTGCCAACATGAC CCACTATCACTCCTGATGAGAAGAG chr2 209113062 209113286NRAS_Q61 TCCCCATAAAGATTCAGAACACAAAGAT ACAAGTGGTTATAGATGGTGAAACCTG chr1 115256361 115256585ASXL1_G652S GAGAGGTCACCACTGCCATAGA GGATAAGGCGGCAGTAGTTGT chr20 31022396 31022617ASXL1_W960X CAAACCAGAATCCAGAGAACACATAC TTTCAATGTCCACCTGTTGACAGTA chr20 31023248 31023459ASXL1_E1102D CCAAAAGATCCCAGATTCCCTACT GGCTCTGGTCTTTTGTAAGTGGTAC chr20 31023734 31023945RUNX1_R201X ATCTGAGACATGGTCCCTGAGTAT ACCTCATTCTGTTTTGTTCTCTATCGT chr21 36231688 36231912U2AF1_Q157P GGGTTGGAAGGAGACATTTACTACC CTTTTCAGTTTCGCCGTGAGGA chr21 44514682 44514906U2AF1_S34F AAAAGGCAAACAAACCTGGCTAAAC TCTGTGTCATGTTTCTGTGAGGTTAAA chr21 44524410 44524630GATA2_A350_C351dup TCCCCGTTGGCGTTTCG GGTTCTGAGATGCTTTGATTCCCATG chr3 128200705 128200929GATA2_C348_C351dup TCCCCGTTGGCGTTTCG GGTTCTGAGATGCTTTGATTCCCATG chr3 128200705 128200929GATA2_R343_T347del TCCCCGTTGGCGTTTCG GGTTCTGAGATGCTTTGATTCCCATG chr3 128200705 128200929GATA2_T354M_ TCCCCGTTGGCGTTTCG GGTTCTGAGATGCTTTGATTCCCATG chr3 128200705 128200929GATA2_A372T_ AAGCCAAGCCAAGCTGGATAT CGGCACCTGTTGTGCAAATTG chr3 128200558 128200770GATA2_C348_C351dup AAGCCAAGCCAAGCTGGATAT CGGCACCTGTTGTGCAAATTG chr3 128200558 128200770GATA2_R362G_ AAGCCAAGCCAAGCTGGATAT CGGCACCTGTTGTGCAAATTG chr3 128200558 128200770GATA2_R362Q_ AAGCCAAGCCAAGCTGGATAT CGGCACCTGTTGTGCAAATTG chr3 128200558 128200770GATA2_T354M_ AAGCCAAGCCAAGCTGGATAT CGGCACCTGTTGTGCAAATTG chr3 128200558 128200770GATA2_A318D GCTCCTACCAGTCTTCGCTTG CTCCCGAGAACTTGCCGGTTA chr3 128202695 128202904GATA2_A318G_ GCTCCTACCAGTCTTCGCTTG CTCCCGAGAACTTGCCGGTTA chr3 128202695 128202904GATA2_A318T_1 GCTCCTACCAGTCTTCGCTTG CTCCCGAGAACTTGCCGGTTA chr3 128202695 128202904GATA2_A318T_2 GCTCCTACCAGTCTTCGCTTG CTCCCGAGAACTTGCCGGTTA chr3 128202695 128202904
Supplementary Table 1: AML Amplicons
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GATA2_A318V_ GCTCCTACCAGTCTTCGCTTG CTCCCGAGAACTTGCCGGTTA chr3 128202695 128202904GATA2_G299R GCTCCTACCAGTCTTCGCTTG CTCCCGAGAACTTGCCGGTTA chr3 128202695 128202904GATA2_G320D_ GCTCCTACCAGTCTTCGCTTG CTCCCGAGAACTTGCCGGTTA chr3 128202695 128202904GATA2_G320V GCTCCTACCAGTCTTCGCTTG CTCCCGAGAACTTGCCGGTTA chr3 128202695 128202904GATA2_L321F_ GCTCCTACCAGTCTTCGCTTG CTCCCGAGAACTTGCCGGTTA chr3 128202695 128202904GATA2_L321H_ GCTCCTACCAGTCTTCGCTTG CTCCCGAGAACTTGCCGGTTA chr3 128202695 128202904GATA2_N297D GCTCCTACCAGTCTTCGCTTG CTCCCGAGAACTTGCCGGTTA chr3 128202695 128202904GATA2_N317H_ GCTCCTACCAGTCTTCGCTTG CTCCCGAGAACTTGCCGGTTA chr3 128202695 128202904GATA2_N317S_ GCTCCTACCAGTCTTCGCTTG CTCCCGAGAACTTGCCGGTTA chr3 128202695 128202904GATA2_P304H GCTCCTACCAGTCTTCGCTTG CTCCCGAGAACTTGCCGGTTA chr3 128202695 128202904GATA2_R307W GCTCCTACCAGTCTTCGCTTG CTCCCGAGAACTTGCCGGTTA chr3 128202695 128202904GATA2_R308Q GCTCCTACCAGTCTTCGCTTG CTCCCGAGAACTTGCCGGTTA chr3 128202695 128202904GATA2_R330L GCTCCTACCAGTCTTCGCTTG CTCCCGAGAACTTGCCGGTTA chr3 128202695 128202904GATA2_T303S GCTCCTACCAGTCTTCGCTTG CTCCCGAGAACTTGCCGGTTA chr3 128202695 128202904GATA2_Y322C GCTCCTACCAGTCTTCGCTTG CTCCCGAGAACTTGCCGGTTA chr3 128202695 128202904DHX15_p.Arg222Gly CAAGCAGAGGACTAAAAGCGTCA GTGTGTGGAGTACATGCGATCATT chr4 24572235 24572459KIT_M541L CTGTTCACTCCTTTGCTGATTGGT CCATTTATCTCCTCAACAACCTTCCAC chr4 55593404 55593628KIT_D816V CCTTACTCATGGTCGGATCACAAA TTGACTGCTAAAATGTGTGATATCCCT chr4 55599271 55599485NPM1_c.859_860 GTTAACTCTCTGGTGGTAGAATGAAAAATAGA GATATCAACTGTTACAGAAATGAAATAAGACG chr5 170837411 170837635NPM1_c.863_864 GTTAACTCTCTGGTGGTAGAATGAAAAATAGA GATATCAACTGTTACAGAAATGAAATAAGACG chr5 170837411 170837635NRAS_G12 ACCTCTATGGTGGGATCATATTCATCT GTCACACTAGGGTTTTCATTTCCATTG chr1 115258669 115258893NRAS_G13 ACCTCTATGGTGGGATCATATTCATCT GTCACACTAGGGTTTTCATTTCCATTG chr1 115258669 115258893EZH2_D146H GCTGTAATGGCTACACAGAATCCTA CATTATTGCTTCTCCTGTGTGTTTCTG chr7 148525793 148526017JAK2_V617F AAAGTGCATCTTTATTATGGCAGAGAGA CAGATGCTCTGAGAAAGGCATTAGA chr9 5073606 5073830CCND1_R291_Val293 CCTGCTGGAGTCAAGCCT CAAAATGCTCCGGAGAGGAG chr11 69465921 69466145CBL_K322 CTGTTCATAGTTATATCTTCCGGCTGA GTCATTAATGATGAGGTTGGACAGC chr11 119146697 119146915CBL_E366 GGAAACAAGTCTTCACTTTTTCTGTTAACAT GTGTCCACAGGGCTCAATCTTTAC chr11 119148790 119148974CBL_D460 GTACTGAACCCATCGTGGTAGAT AAGTGTTTTACGGCTTTAGAAGACAAC chr11 119149266 119149490CBL_R343 TGGAGAAACTCCCAGATTCCATTTG ACTAAAGCTTGTGTCCAGTGATATGG chr11 119148379 119148603CBL_P548 GATTCTTTGCTGTGTACTAGTGGGT TTGTCTCTGGAGGGACAGTCG chr11 119155841 119156065CCND2_Lys234 CCTCTCATTCCTTGCAGACTTTAAGTT GCTGAGAAGAGACATCTGGACTTAG chr12 4397991 4398204CCND2_CCND2 AATAGCCTGCAGCAGTACCGT TAAGTTTCACCCTAAAACACAAAGAACAAAAA chr12 4409071 4409271TET2 AGTGCTAATTACCATGACAAGAACATTGTA GAGGTCTGTGCGGAATTGATCT chr4 106155664 106155938TET2 CCAGAATAGTCGTGTGAGTCCTG TAACTGCATTTTCTTGGGCTACAGA chr4 106155306 106155580TET2 CCTGATGGAACAGGATAGAACCAAC TTTGCAAACACTTGGAATACCCTCT chr4 106155096 106155370TET2 GCTGTCAGTTGTCACTATGAAACATG GATGGTATCAGGAATGGACTTAGTCTG chr4 106154887 106155161TET2 GGTAAGCCAAGAAAGAAATCCAGGT GAGGCAGAAACTGTAGCACCATTA chr4 106155477 106155746
Supplementary Table 1: AML Amplicons
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TET2 ATATGCCCATCTCCTGCAGAAAATAA GGAGAAAGAAGCAATTGTGATGGT chr4 106156090 106156322TET2 CCTCAAGCATAACCCACCAATTTTTG TGGAGGTCATTTGATTGGAGAGATTG chr4 106156632 106156906TET2 GGAAGTGAAAATAGAGGGTAAACCTGA CTTGCTCTTTGTTTCTCATCAACTGC chr4 106156440 106156714TET2 TGAGATCACTCACCCATCGCATA AACAGAATTCTTCACCAGACGCTAG chr4 106155885 106156159TET2 TTACTTCAAGCAAAGCTCAGTGTTC TGCATACATGTGTAGATGGATTAGGAC chr4 106156236 106156510TET2 AGTTGAAATGAATCAAGGGCAGTCC CCTGTTTATGAGGCTTATGTTGCAAA chr4 106157004 106157278TET2 AAAGCAACAATGATCAGCAAAGAGAAG TGCAAAAAGTTCAGGATGTGTAGTCT chr4 106157390 106157664TET2 CATCTAAAACGTAATGAGGCATCACTG GGTAAATGGTCTGTTTTGGAGAAGTG chr4 106156831 106157105TET2 GCACTTGAATCAACAGGCTTCAG TTTCACCATGAAAACATTCTTCCACTTT chr4 106157202 106157464TET2 TCTTGTTCAAACAATACACACCTAGTTTC TGGTTATGTATCAAGTACCTTTGCTGA chr4 106157596 106157870TET2 AATAGAAACCAAGATATGTCTGGTCAACAA CTTGCATCCAGGTTCCACCTTAA chr4 106157800 106158063TET2 AGAGTCACCTTCCAAATTACTAGATACTCC TCTTTCACAAGACACAAGCATCG chr4 106158414 106158688TET2 CAAACTGAGTCTTGCCATAGTCAGAT CCTGACATTTCAACTTTTACTTGCTTCT chr4 106158004 106158278TET2 TGACCATAAGGCTCTTACTCTCAAATC AGATGGGAAATCATATTGAGTCTTGACA chr4 106158222 106158495TET2 TTTAGAGCCCTTAATGTGTAGTTGGG CTTTGTGTGTGAAGGCTGGAAAAATT chr4 106162393 106162667TET2 GTTCATTTCTCAGGATGTGGTCATAGA TCAGATTTACAAATCAAAATGCCCAAGA chr4 106163872 106164146TET2 ACTGGTAAAGAAGGCAAAAGTTCTCA CTAGAATGGACCTCTTCCTCATCAC chr4 106164037 106164311TET2 CAGTGAAGAGAAGCTACTGTGTTTG TGAACTCTCTTCCTTTCAACCAAAGATT chr4 106164744 106165016TET2 TTTTATAGATGGGCAGCAAAAGGC CACCAGGATGAGAATCACAATCACTG chr4 106164555 106164828TET2 GTGTGTGGTTATGCCACAGCTTAATA CAGCTTAAACTTCCTTGGGATCTTG chr4 106180634 106180905TET2 TGGTCTTTTGATTTTTCAGGAGAACTTG AGAGCTTACCAAGATATGTCATATTGTTCA chr4 106180757 106181021TET2 AAAGGCACCATATATTGTGTTTGGGA CAAGTAAGTTGTTACAATTGCTGCCA chr4 106182795 106183049TET2 TCACTTTATACAGGAAGAGAAACTGGAG AACACTGCAGTGGTTTCAACAATT chr4 106182903 106183144TET2 AAAGTTCTAAATGGTCTAAATACTAGTGAGTTT tgagaacagactCAACAGCTGCTA chr4 106190678 106190950TET2 CAGAATGGCAGCACATTGGT aggagagtaagtctcatgagatctgatgat chr4 106190887 106191161TET2 CACCAACACAAATCTGAATACTGAGAG GCCGAAAAGAACTCAGTACCTGAAT chr4 106193618 106193892TET2 CCAGTCAAGACTTGCCGACAAA gtgtaccccagaacttacaaGTTGATG chr4 106193916 106194180TET2 AGCTTCACGTTCTGCCTTTATACA TGCGTTTTCAGTTTGTTTTGTACGTG chr4 106193779 106194053TET2 CCAAGGTTTGGAAATAGCCAGAGTTT GGAGCTGCACTGTAGTTATGGATTA chr4 106196708 106196976TET2 CCTCAGACAGAGTCTGTCAACTCTTA GAGCAGTTGTCCACTGATAGGTT chr4 106196321 106196595TET2 TCTAATCCCATGAACCCTTACCCT CCCTGCATATTTTGGTTTCCATAACC chr4 106196501 106196775TET2 ACCTACATTTAAGTATCCTCACTAGCCT GGCCGTCTCATGTATGGATTGG chr4 106196116 106196385TET2 ACCTCTAGATTACCACCCAATCTGA GCTTTTCCTGACCATTAGCATCACT chr4 106196876 106197149TET2 CATGAAACTTCAGAGCCCACTTAC GGTTTTTCCCACCACATTTGTCATG chr4 106197536 106197802TET2 AACCCCTTTAAAGAATCCCAATAGGAA TCCTTTCGGCAAGAGACTTGATG chr4 106197316 106197590TET2 GTGTCCAAGGAGGCTTACACAAATT TAAAAGACGAGGGAGATCCTGGT chr4 106197099 106197372TP53 GGGAATATTCAACTTTGGGACAGGAG CTTCTGTCCCTTCCCAGAAAACCTA chr17 7579132 7579403
Supplementary Table 1: AML Amplicons
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TP53 GGTCTTCAGTGAACCATTGTTCAA GAGACCTGTGGGAAGCGAAAATT chr17 7579515 7579777TP53 CAACTGACCGTGCAAGTCACA CCAAGCAATGGATGATTTGATGCTG chr17 7579304 7579576TP53 CTATTGCAAGCAAGGGTTCAAAGAC TCTCACTCATGTGATGTCATCTCTCC chr17 7572828 7573056TP53 GAAGTGGAGAATGTCAGTCTGAGT ACACTAATACTCTGAGGTGCTCAGT chr17 7572914 7573183TP53 CAGGAAGTCTGAAAGACAAGAGCAG CAGGGTTGGAAGTGTCTCATGC chr17 7579714 7579987TP53 AAGGCAGGATGAGAATGGAATCCTAT aaagtcaaacaattgtaacttgaaccatct chr17 7573843 7574117TP53 aaaaagcaggctaggctaagct CTCAAAGACAATGGCTCCTGG chr17 7576458 7576732TP53 CCAATTGCAGGTAAAACAGTCAAG AGGGAGCACTAAGCGAGGTAAG chr17 7576761 7577035TP53 CATAACTGCACCCTTGGTCTC GGAGTAGATGGAGCCTGGT chr17 7576969 7577243TP53 GCCACAGGTTAAGAGGTCCCAAA TACATGTGTAACAGTTCCTGCATGG chr17 7577301 7577575TP53 CAGTGTGCAGGGTGGCAA aaaaaGGCCTCCCCTGCTT chr17 7577469 7577683TP53 TCATCCAAATACTCCACACGCAAA AGCTGTGGGTTGATTCCACAC chr17 7578226 7578499TP53 ccatttactttgcacatctcatggg TGATTCCTCACTGATTGCTCTTAGG chr17 7578039 7578313TP53 TGACTGCTTGTAGATGGCCATG TCCTGAGGTGTAGACGCCAAC chr17 7578432 7578704WT1 AGATGAGCTTACAAACGAAATTTGGC AGCAGGGCTCTGAGGATTGTG chr11 32451869 32452143WT1 AGTTTTCTCTAGACGAACCCTTCTC ACCTGAAGGAGAGGGTTTGAGG chr11 32452058 32452332WT1 AGCAGCGCGTTCAGGTC CGTCTCCTCGCCGCGAT chr11 32456653 32456924WT1 GGTAAGAGCTGCGGTCAAAAGG CCTTCACTGTCCACTTTTCCG chr11 32456142 32456416WT1 TCAGGCACTGCTCCTCGT GCAAATGGGCTCCGACGT chr11 32456420 32456691WT1 ATCCTGGCCTGGCCGGATG CCGGTGCTGGACTTTGCG chr11 32456308 32456582WT1 CTTGGAAGTTGGATGAAGAAGATCAAC TCTCTGACTGGCAATTGTGTCAAC chr11 32410477 32410751WT1 CGCCTAACTTGGCCCAGATG CAACCCGACCGCCTGTCC chr11 32456759 32457033WT1 TGTGATGGCGGACTAATTCATCTG TATTTCGATCCTTAAAGCCCCAAGA chr11 32410648 32410922WT1 GGGAGAACTTTCGCTGACAAGTTT GTTAAGGAATGGTTGTTCCCAAGAC chr11 32413566 32413840WT1 tttaaaGATAGCCACGCACTATTCCT GGCTAGACCTTCTCTGTCCATTTAG chr11 32413367 32413635WT1 GCTGACTCTCTCATTCATATTCAACAAC CTGTTCAGTCCTAGTAGGAGAGGT chr11 32414113 32414387WT1 CCTGGAAATAACCTGGGTCCTTAG GACTCTTGTACGGTCGGCATC chr11 32417710 32417924WT1 GCATCTGTAAGTGGGACAGCTTAAA TGCCACCCCTTCTTTGGATATACT chr11 32417821 32418059WT1 CCAAAGAGTCCATCAGTAAGGAACTAA CATCATTCCCTCCTGATTGCAGAT chr11 32421403 32421676WT1 CCTGATTACCCACGTCAGTCCTA CACTCTTGATAGCTAGCTTGATGTCT chr11 32437938 32438212WT1 GAGCTTTGCCCTTTCTTCTAAAACTG ACTCCATTGCTTTTGAAGAAACAGTTG chr11 32439008 32439277WT1 CCAAGTCCGCCGGCTCA CCCAGGCTCAGGATCTCGT chr11 32449431 32449705WT1 GGAGAAGGACTCCACTTGGT TGGCTGGTTCAGACCCACT chr11 32450010 32450239WT1 CCCTCCGGACATTCATAGACTTAG CCACTCATTCAAGCATGAGGATC chr11 32449816 32450089
Supplementary Table 1: AML Amplicons
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Gene_Symbol Ion_AmpliSeq_Fwd_Primer Ion_AmpliSeq_Rev_Primer Chr Amplicon_Start Amplicon_StopASXL1 CCGAATTCCCAGTTGAGTCTGTG GCTTTTCGGTGTGAACACTTTCAATT chr20 31021437 31021679ASXL1 CCTCAGTTGCATCCGGATGTTA CCACCAAGCCCTAATTCGTCAT chr20 31022850 31023124ASXL1 GGTCTAGATCCTCTTGACAGCCTT GATTGGTTCCAATTGGGTTTCTCAT chr20 31023360 31023634ASXL1 CTCCATCCAGTGACAAATCCCATTAC TTGGCCTGTAACATTGCTCTGATC chr20 31024152 31024415BAZ2A CGCATGGTGGAAAAATCCATAGGAT ACAGTGATCTCACATTTTGCGAGT chr12 56992673 56992934BAZ2A GTGGTTCCGCATAGAGAGTCG GAGATTGTAGTAGGGCAAGCAGT chr12 56992936 56993208BAZ2A_300 CCCCTGATTGCCTAATACTTTTCCC TCTGTCCCTTCTGTGGAATCGT chr12 57007637 57007896BAZ2A_K216 CCCCTGATTGCCTAATACTTTTCCC TCTGTCCCTTCTGTGGAATCGT chr12 57007637 57007896BAZ2A caAGGAGAGGAGAGATTGAGGATAATC AACCTTGGTCCAGACATGTCTAGT chr12 56993414 56993645BAZ2A TGTCAGCTGGGTTAGGTAACG TGCCTGAAGTTGAGGGAACCTATA chr12 56994983 56995255BAZ2A GTGGCAAGATGAAATCAAGTGCATA CTCAGTCCTCACACCTGATAGCA chr12 56995284 56995552BAZ2A CCTCTGTTCCTTCTACAAAGATACCA CACCTTCTGAATTAGGCCCAGAT chr12 56996506 56996780BAZ2A GGTGGTCAGTCAGACACATATCC TGATATCTTTATGGCAGTCTTGGTTCC chr12 56999616 56999890BAZ2A TGCAAAATCAGTTTAGTGGCTTCG GCATCTCTAGGGTGAGAGAATTAATCC chr12 56999973 57000247BAZ2A TGGAAAGACAAGTTTTTCTCACCTCAA CACAGACTTCTCCTATGTTGGGAT chr12 57008706 57008965BAZ2A_K216 GGATTGGAGTGTCTTCCAGTTGATC GCAATGAACTGGCCGCAATAAAT chr12 57007779 57008052BIRC6 TAGCCACATTTCTAGCTCAGAAAGC TCTGTTGTGCACCTAAATTATGGC chr2 32740420 32740694BIRC6_H1622del TCTTTAACCTTTTCTTCATCCTGGTGT ACAAAGAGCCAAATAGTCTCCAACC chr2 32688199 32688473BIRC6_H2654 AATTTTCAGTATCACAGTCTCCCACTG CCCAATTAGTTTCATCTTTTACCAGGCT chr2 32712705 32712939BIRC6_I2165_trunc ATTTGATGTTCTACTCAGTTTCTGGCT CTTCATCTTCAACAGTTGCCACATAA chr2 32695892 32696165BIRC6_K2270 CAAAGCAGAAGGCATTGGTAGAAC TCCTTCAGTTAAACTACCCCACCAA chr2 32701300 32701566BRAF_x11 TGCGAACAGTGAATATTTCCTTTGATG AAGGTTTTCTTTTTCTGTTTGGCTTGA chr7 140481273 140481547BRAF_x12 AGTAAATCTGTAAAGCTAATAGTTGCTACCA GGGCTATGATAATTAGTGAAAACACCCA chr7 140477695 140477968BRAF_x14 AGTCAGGATGTTTTCAAACTTCGC AAGTCTTTACACCCCCAAGTATGTT chr7 140453941 140454122BRAF_x15 ACCTTCAATGACTTTCTAGTAACTCAGC ACCTAAACTCTTCATAATGCTTGCTCT chr7 140452995 140453267BTK GACGATGGCAGCTTTGACACT TTGAGTGAGTTGACTGAATCACTGA chrX 100614167 100614441BTK GAGAGAGAGAGTTCCTCCTGGAA CTAACCATGCATCAGAGACATGATTG chrX 100615025 100615296BTK CTGATCACGGGAATTATGCCG AGATCTTGAAAAAGCCACTACCG chrX 100615471 100615745BTK TAAGCTTGGGATTTCCTCTGAGAAAG CATGCTACTGGGCATAGAGCATATATTT chrX 100604793 100605058BTK ATTTTTATCTCGTGCTCTCCACCAT GTGTCTTGAGTAAGCCAGAGAGTTG chrX 100615558 100615832BTK ACAAATCCCCCATCTTAGCAAGAA cctgACCAAACCTGTCCTTGG chrX 100617026 100617299BTK CTTGACAGACCCTTGGGAGA CTCAAAGAGGAAAACATGCAAATGG chrX 100617478 100617752BTK ATTTGTCTTTCTTTCCTCCCTCATCC TGGATTCACCAGCTCAAAAACG chrX 100624738 100625007BTK ccttccttTCCTTCTTTCTTTGGAAAC TGTCCCCTAAGATTAGTACTTTCAAGGT chrX 100624935 100625150BTK TTGTCCACCTCAACTTCTATTCACT CCACAGCAAAAGGCTTCTAGTACC chrX 100626501 100626775BTK AAACTTGACCGTGTTCCACGTT TCATCTGGTTGCTTAATCCCTCTTAATC chrX 100629409 100629683BTK AATCTGTCTTTCTGGAGGAGGATTTT TTTGCCCTCCATTTGGTAGTCATAG chrX 100629527 100629801BTK AACGAAAATTTACCTCTTCCCCAAGA AACTTTCATTATCAACAGCACACAGG chrX 100630046 100630320
Supplementary Table 2: CLL Amplicons
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BTK ACCCCACGTTCAAAGTCATACTC GCACATTTTTGTTCCATTTGAAACTAGG chrX 100630130 100630404BTK GCCATGTGATAGATGAACTGGAACA CAGCTTTCAACGTTTCGTCACTTTAT chrX 100645533 100645797BTK CATTGTCACTTTTCAGAACCTAGAGC GCAGCAAACTGCTAATTCAATGAAGAC chrX 100645327 100645599BTK TCCTAATAAAGCACTTACCTCATGCC ACCAACTGATTCTAATCTTTGAGGTTGA chrX 100608164 100608438BTK aaaGAATGTGTGCAGCTATCAGTCT GGGTTTTGATGTGGGAAATTTACTCC chrX 100608081 100608339BTK GTGTAATCTTATCCACTTACCAAAAGCC AAGATACTAGTTGAGGAGGAGAGACTTT chrX 100608838 100609111BTK tgaaAGCAAGAACAATATCTCTGTGGA GCAAATATCAAGCCTCCAAATCCTAAT chrX 100608755 100609028BTK TCGGCAGAAAACGCTAGAATGA CTTCATTCTACTGGTCAGCAGAAG chrX 100609495 100609767BTK GATAAAATTGAAATGATGGCACCAGCA CATCATCACTGAGTACATGGCCAAT chrX 100610925 100611193BTK AGACATCCTTGCACATCTCTAGC ACCCCTTATCTGATGCTCTACTCCTA chrX 100611090 100611364BTK GTCCCAAACCTCTCTTACTGTAAGT TGGGAAATTGATCCAAAGGACCTG chrX 100611664 100611938BTK TGGGCTATAACTCACATCATGACTTT CCTATTTCTACCCCAGTAGGGATTTTT chrX 100611757 100612031BTK TACCTCAAGGACACTCCCTAAGGC AAATGTACTAGAAAGATACACACCGGAA chrX 100612408 100612680BTK GGTGTGGAACACACAACATAATGAC CAGCAAAGCTGGCAAATATACAGT chrX 100613381 100613652BTK GTGAGGCAGATTCTTCCTCTTATCA CTGTTGACCTTTGTGCCCAAGTTA chrX 100613210 100613473BTK CCTTGGAATAGTAGCACTCACCCT TTAAAAGCAATGAGGCTGTAGCTCAA chrX 100613584 100613829CCND2_E35 CCCGAAAACCCCCTATTTAGC ACGCACTTGAAGTAGGAGCACT chr12 4383074 4383346CCND2_E35 GAACCTGCTCACCATCGAGGA GAAATAAAGCCACGCGTCTCG chr12 4383290 4383563CCND2_G268_T280_P281 ATTACGCATGTTTTCTCCGTAGGA GACCAGATTATGGACGCGTCT chr12 4408948 4409221CHEK2_A435 TAATCACCTCCTACCAGTCTGTGC AGAGACCTCTCTCATGAGAACCT chr22 29091653 29091829CHEK2_A435 CAAGAACTTCAGGCGCCAAGTA TCCTAACTTGCAAAGACATGAATCTGTAA chr22 29091768 29092026CHEK2_E351_N359 CTGAGTTTTAATCCACGGTCCCT TTGTTGTTTTATTGTCTTCTGTCCAAGT chr22 29095728 29096000CHEK2_R188 TGCAATGTAAGAGTTTTTAGGACCCA AGAATGTGTGAATGACAACTACTGGT chr22 29121083 29121357CREBBP_A1925 GGCACATTCAGGCTCACG CACCCGTGAGCATGTCACC chr16 3779040 3779313CREBBP_E1925_1963 GGCACATTCAGGCTCACG CACCCGTGAGCATGTCACC chr16 3779040 3779313CREBBP_A1925 TGGGCCTCACGCTCGAT AACGTGCCTCAGCAGAGTC chr16 3779148 3779422CREBBP_E1925_1963 TGGGCCTCACGCTCGAT AACGTGCCTCAGCAGAGTC chr16 3779148 3779422CREBBP_K420 CCACTCCCTACCTACTCTCTGAATTTT ACATCTCGTTGTTTTTCTGGTCATAGT chr16 3841898 3842121CREBBP_P12 TCCCGGCTCGATCGGTA CTGTTTTCGCGAGCAGGTGA chr16 3929730 3929939CREBBP_Q104 CTGAAGAATCTCCCTGGCTCAGA ATCTTCCTGATGAGCTGATACCCA chr16 3900708 3900980CREBBP_Q1292 GCCATCTCTCTTAATCGCTGAATTCT CACACACAGACTTCTACAAGTGACTC chr16 3795157 3795431CREBBP_Q2318 GTTACTAAGGGACGTGGCGATC AACAGCAGATGAAGCAGCAGATT chr16 3778025 3778155CREBBP_Q355 GCGTCATGTGATTCAAAACGTTTTTC AATGAATATGACTTGGAACTCTGAGAGG chr16 3843414 3843688CREBBP_Y1230 cTGAAATTGGGCCACTTTTTATTGGAA ATTTTTGCAGTATGAGTTTTCCCCACA chr16 3807174 3807387DDX3X caactactTGAATGCAGTACTAGCAAAT AGCCCAATGAAATCTTAAGATGTTAAGC chrX 41196557 41196783DDX3X AACACTGTCATCTACCAATGTCTGTTTAA TCTTAGCATCATTTAGAAAGCCCTCTC chrX 41202923 41203154DDX3X TGAGAGGGCTTTCTAAATGATGCT TCACTGGAACTCATACTTACTTTTCTGG chrX 41203127 41203401DDX3X ACCCAATCTCCTTGGTATTAGCAC CTAACAAATGGCATCCACGTTCC chrX 41203314 41203588DDX3X GGAAATACAGGTACTGTTTGATGTTGC TGTTACCTGTTGCATTTAGGAGGTC chrX 41204568 41204807
Supplementary Table 2: CLL Amplicons
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DDX3X AACCTATAATTTTTCAACGACAGGCAA TGGCCCACTTAAAAGAAAACAAATACTT chrX 41205459 41205733DDX3X AGCAAGTTACTTTATGGAAGACCTTTGT AGAGGAAACACTATGAACTGTAAGTGAA chrX 41206056 41206330DNMT3A GTGTCCTTCTTCTAGAATCAGGATCCA catgaaCAGCTAAACGGCCAGA chr2 25498315 25498544DYRK1A_x8 TCTCTGTTTAGTTTTTGAAATGCTGTCC CAAGTTCTGAAATAATACTTACCCTCTGC chr21 38862511 38862785EGR2_x4_E356_H384_D411 CTGTTACTGCTGCACAGGGTAC CATAAGCCCTTCCAGTGTCG chr10 64573025 64573299EGR2_x4_E356_H384_D411 GCAAACTTTCGGCCACAGTAGT ATTCTGAGGCCTCGCAAGTAC chr10 64573175 64573440EWSR1 ATTCTAACCGAAGGGCCCTCT AAAACTCCGCACACTACCATTTAAC chr22 29696080 29696340FAM50A CACTGTGGAGAAGGATGAGGTACA CCTCCTCACCGTGTACTTGTC chrX 153678429 153678676FAM50A GAACCCTACGACCCTGAAAAGAAG ATGCTCAGCGGATCTAGTGTGA chrX 153678629 153678784FAM50A_D207 TCTGCCTTGTAGGTGAGGAGATC CAAGTCAGGAAGGTCAGTTCCTT chrX 153677229 153677387FAM50A_D207 AAGCAGGAGAAGATCAAGAGTGAGT CATCCCAGTAGCTGAAGGTGAT chrX 153677086 153677276FUBP1 TATTTGTGCTATCCTTTCGGGTGT ACCCTGAGAAGCTAGCTTTCTTAATACT chr1 78429813 78430087FUBP1_G119 AGAATGTAACATTACCAGGAGCTATCTG ATCTTTCATTGAAGGAAAATGGTGCTTT chr1 78432553 78432827FUBP1 AGAATGTAACATTACCAGGAGCTATCTG ATCTTTCATTGAAGGAAAATGGTGCTTT chr1 78432553 78432827FUBP1 GAAATTGTTACTTTAGCTTTTGACCCAGT GGGTTGAATTTTGGCAGTTTTGGTT chr1 78433803 78434034FUBP1 GGGAAACGTGTCTCTTCACATTTCA TCTTATAGTGCAACCATGGCAGAC chr1 78444432 78444703FUBP1_E249 ACTTACATCTATCCCTTCATTTCCTCCT TGACAAACCTCTTAGGATTACAGGAGA chr1 78430325 78430597FUBP1_G509 GTGAGTGAAGGTGATGCATACAAATGT CTCCTCAGTAAGTATTGGGTTTAGTTCT chr1 78425761 78426035FUBP1_Q413 CTTCTATGAGTTGCCGAGCATAGT ATTGTCAATTAGGATACTGACCAAACCA chr1 78428466 78428740FUBP1_S159 CCCCCTTTTCCAATGACTAATCCTG GTTAAAGTTAGCATCAAGGCACCTAATC chr1 78430775 78431049GNB1 CTTCACTACTAACAAACAGAGCTTGC GGTTTTAGTCTGTTGCTCTTGTACAC chr1 1737778 1738052HIST1H1E_A116_A165_A167 AGCTGTTGCCGCCTCCAA GCTTCTTCGCCGCTCCTG chr6 26156756 26157030HIST1H1E_E42‐R79 AGCTGTTGCCGCCTCCAA GCTTCTTCGCCGCTCCTG chr6 26156756 26157030HIST1H1E_A116_A165_A167 CAGTTAAACCCAAGGCGGCTA CCCCTAATAGTGCAACAGCTCTTTT chr6 26157196 26157379HIST1H1E_A116_A165_A167 CCAAGCCTAAGGCTAAAAAGGC CTTGGGCTTGGCGGTCTT chr6 26156965 26157239HIST1H1E_E42‐R79 CTTGCCTTCAACATGTCCGAGA TTTCTTGAGAGCGGCCAAAGATA chr6 26156607 26156810IKZF3 ACTTCCTAGACAAGGAATGCTCATTTC GCATCTAATCTGTGCATATGTTTCTCCA chr17 37947632 37947906KLHL6_x1 CCTAGGCATGCTGACCTGAAATAG ATGGGTGATGTGGTCGAGAAGA chr3 183273134 183273408KLHL6_x1 ACTGTTCAAGATTGGGCTCTCAC ACAGGAGACTTGGTCGAGATCTTA chr3 183273065 183273339KLHL6_x2 GGTCTGGCCTCTGGAGAATTACT GGCACGATTCACATTCACACATTT chr3 183245562 183245831KLHL6_x2 TGTACGTGTAGTCCAACAGAGTG ACTGATGAAATGTCTAATGCGTAGGG chr3 183245698 183245972KRAS ACCCACCTATAATGGTGAATATCTTCAAAT AGTAAAAGGTGCACTGTAATAATCCAGA chr12 25380162 25380394KRAS ATCTGTATCAAAGAATGGTCCTGCAC AGGTACTGGTGGAGTATTTGATAGTGT chr12 25398152 25398415MAPK1_D162 AAACATGTTTTTGGGTATTTCTGGTGTA TACAAGCTCTTGAAGACACAACACC chr22 22160020 22160294MAPK1_D291_Y316 AAATCTAAGCAAGATATGGTTGGTCCAC AGTATTTCTGTGACTACTTCTGCTCTC chr22 22127083 22127325MED12 CCTTCGGGATCTTGAGCTACG CCACTTTACTCTTCCCCCTTTCG chrX 70338612 70338837MED12 TAGTTTCCGGCAATGGTCGAG GGTCCTGAGGGTAAACATCGG chrX 70338445 70338689MED12 GTTCGCAAGAGAAGAGTGATGTTTGA CTTGTTTTACATTCAAGGCCGTCA chrX 70338985 70339253MED12 AAACAACTAAACGCCGCTTTCC AGTATTAGGTCATGAAGGCAAACTCA chrX 70339193 70339451
Supplementary Table 2: CLL Amplicons
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MGA_A1409_V1432 GGTGAGAAGAACCCTCCTGTTTATTC CCAGATGTACTTGAACTGGGTTTACG chr15 42028612 42028886MGA_I27 GTTTCCTACTGAAATCATGGAGGAGAA CATTCCACATACTATTGTTATCGAGGGT chr15 41961077 41961351MGA_L1063_D1075 ACAATTTTCTCCTTTGACTTTAGGCATC TCATAAAATACTGGATCTCGATGAGCA chr15 42005326 42005599MGA_L998 TTGTTGTGCCAACTTTGGATGAAA GCTCTTTCTAGCCAAGCACTAATATACC chr15 42003324 42003598MGA_Q373_S415 CTTTCTCCTCTCTCTCTCCAGTCTTA CAGCTTCTGGGTTGTCAACTTTATTG chr15 41988252 41988523MGA_R1242_E1249 TTGTTTTGGAGTCTAGCGGAGTTT AGAACTTATGCAACAAGAAACTCACCT chr15 42021298 42021572MGA_R2436_S2456 AGATGTTTAGGAGGCAATCTTGTTTG AGTCAAGCTCTTACTGTCATTTACACA chr15 42052490 42052764MGA__S1301 GAGATTTAATGCTTGTGTCCAAGTTTCT GTTTGAAACAGGGTAGGCAGACATA chr15 42026637 42026911MGA_x17 ATTTCTCCTCCTGAACCACAAAGC GTAGAACCTTCTTCGTTTCTTGCTCT chr15 42041515 42041788MGA_x17 AACTGTCAAACCATCTGAGCATTC GTGACTGGAAATTCACTTGAGTTTTCT chr15 42041934 42042203MGA_x17 TCCAGACCAGAAAGATGAAACAAACTC ATCTTGATCTGTATGTGACCCAGTG chr15 42041727 42041988MGA_Y915 ACTAAGAGTACCAGTTATGTACGAACAC TGATTTTCTGAGATGATGCCTGAAGA chr15 42003038 42003312MYD88_A25 CGCTTCTCGGAAAGCGAAA CCTGTGTCCGCACGTTCAA chr3 38180082 38180318MYD88_L265 GGGATGGCTGTTGTTAACCCT AGGCGAGTCCAGAACCAAGATT chr3 38182530 38182752MYD88M232_P258 GGGTCCAGATACTGGGCATCTC ACCTACACATTCCCTCATTCTCTTG chr3 38182112 38182385MYD88M232_P258 AAGGAATGTGACTTCCAGACCAAAT CTTCAACCCCAGGGTTAACAACA chr3 38182294 38182560MYD88_S174_V172 GAGATGATCCGGCAACTGGAAC GTGGCAACTTAGTTCAGCATATCC chr3 38181944 38182217NOTCH1 AAGTTTTGTGGCTGCACCTG GGCGGGTCCACCAGTTTG chr9 139391022 139391296NOTCH1 AGCTGGACCACTGGTCAGG GAGCTTCCTGAGTGGAGAGC chr9 139390624 139390898NOTCH1 ATGTGTTTTAAAAAGGCTCCTCTGG ACCAGCTACAGGTGCCTGA chr9 139390419 139390692NOTCH1 ATAGTGTGCACCGCCAGGCT GCCTCACCTGGTGCAGACC chr9 139390824 139391063NOTCH1 GGCCTCCTTGCTTCCACAGG ACTTTGCCAACCGGGACATC chr9 139391672 139391943NOTCH1 CACGATGTCGTGATGCATGCG CTTCCTCTGGTGATGGAACCTTG chr9 139391861 139392091NOTCH1 CAGGTGGGTGTCGGGCAT CGTGCAGGGCAAGAAGGTC chr9 139391465 139391735NOTCH1 CGGGACAGCCACTCGCATT CGTTCCAGCAGTCTCCGT chr9 139391253 139391526NOTCH1 CCAGGTGCAAGGCGGTCT GTGGTGCATCCACACCGT chr9 139395135 139395409NOTCH1_x13 CTGATGTGTCCCCATGATCGG CCCTTAGGGAGCATGTGTAACATC chr9 139408928 139409161NOTCH1_x17 CTTATGGCCAGCACCATGCG GACCTGTGAGGTCGACATCAAC chr9 139405014 139405253NOTCH1_x5 ATGCCTGTGAGTGCAGTTTAGTAA GCCAGAACTGTGAGGAAAATATCG chr9 139413817 139414008NOTCH1_x6 GGCACAGTCATCAATGTTCTCG CCTGCAGGTCAGTACTGTACCG chr9 139413122 139413283NOTCH1_x7 GGGTCCCATCCCCCATCTAAC CTCAACGACGCATGCATCA chr9 139412476 139412730NRAS_Q61 AGGTTAATATCCGCAAATGACTTGCTA TGCTTATTTAACCTTGGCAATAGCATT chr1 115256427 115256697NXF1 aaaaaGATTGATGTGTGCCTGGGT GTAGGAAGCATGGACAGAGTAAGAAC chr11 62564574 62564789NXF1_490 GAAGCTAAGAGTGCTGAGGAAAATTC CAATTCCTTCGTGGTAGACATAAGC chr11 62563297 62563571NXF1_502_511 AATCACCCCAAAGACTGACTCTAC ATTCCTCTCTGACTTGCTAGGATTCT chr11 62562316 62562590NXF1_k22 CCAACTGGTCACTCACTATCGTAC AGAAGCTATGATTGCCACACCAAA chr11 62571248 62571522NXF1_L212 TTGTTGGGAGCCATCGTATCG CTTAGGCTTCCCTAGAGTTTTCTGTG chr11 62569068 62569338NXF1_L490‐R511 TTCTCTGTCTCCTTGGTAGCCTATG GACCCTTTTCTCAGGATCCACTTG chr11 62567127 62567374NXF1_L490‐R511 CAAGAGAGACAGATTGCATGCCA CCCTTTCTACTCTAACCAGAGGGTAT chr11 62567279 62567548
Supplementary Table 2: CLL Amplicons
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NXF1_R78 ACTGTAATCTTGAACCAGTTCTTTGAGG ATGCCAGGACTAGCTTAGTGATTAAA chr11 62570889 62571163NXF1_S340_K384 GAAGAGAAGAGAGAACATCTCAGGAC CTAGAAGAGCTCTGGCTCGATG chr11 62567651 62567916PAX5_enhancer GAAAGAGAGGACTGACGTCAGGT TCGGAATTCATACAGGCTCGGA chr9 37369297 37369549PAX5_enhancer AGAAATGATCCTCACAATTAACTGCATC TGAGACTTGGTGTGGAAGATGAG chr9 37369564 37369838PAX5_enhancer agatccAAACATCCAGCCAGCA CCGTTCTGCTCCAATCTCCAC chr9 37369479 37369666PAX5_enhancer2 GGGACATCTATGGTTGGGTGTTG CCCTGGTGTTGTGTATGTTGTGAG chr9 37371075 37371348PAX5_enhancer3 ccagcctctgagtaccaccttatc GCCTACCCACCACGTTGAGAAG chr9 37371806 37372071PAX5_enhancer3 CTGCCACACCTCCTTTTGATCTAC gaggctgagaacgtaaagagacaat chr9 37371618 37371878PAX5_enhancer3 CAGAGAAAGTCTCCCTCCAGCT GGCCCACAGCATGAGTAAATTTTCA chr9 37371422 37371695PAX5_promoter GCACCGTGAAATGATTAAGGAACT CCCCCAACCCCTATAAAAGTCT chr9 37034242 37034514PAX5_promoter GGGCCGCTCACAGGTCG GCGCAGCGCCTACCCTT chr9 37034132 37034395PAX5_promoter ACTGATGCAGAAGTGTGTGAACAG AAAAAGTGGAAACTTTTCCCTGTCC chr9 37033807 37034079PCLO TAGGCTCCAATTTCTCCACTATGTC TGGAGAGTCTACCAAGATCTCAGAAAAT chr7 82508709 82508982PCLO TTTCACAACTAACCATAAGGAGAGAGG GGATTAGGAATTAGAATTGTGGGTGGT chr7 82508524 82508773PCLO_5018_downstream GGCAGCCACTTGTGCTTATAATTTC TGTCCCTTTGTCTGTGTAAGAACG chr7 82451445 82451691PCLO_L1107 TGAGATGATGATTCTGTAGGAACAGG ATTTGGAAAACAGTGACCCACCTT chr7 82595667 82595940PCLO_L473 TAGGCTGTTGAGCTGAGGGTT AGGACCCGGAAAGACTTCTGC chr7 82784324 82784595PCLO_L473 CAGTTGTGAAGGAGGCTTTGTTG CCAAAACCCCTAGCTCAACAACC chr7 82784538 82784705PCLO_S3733 ATCAATCTCCTTTTCTTCTTCATCAAGC AGACTAAAGGTTCTCAAACCATGACA chr7 82545917 82546191PCLO_T1415 CTGAGTTTTCTCTTGGTCTTTAGGCT ACACGGGATATTCTTCCGATGG chr7 82585910 82586184PCLO_V4869 GGTTTTGCTTTGACTGCGAGATG TCATTCTGTATGATGACCAGTTGCAT chr7 82451896 82452155PCLO_Y4568_S4576 GAAAATCTTGCTAACTGGCAAAGGT TGCCATATGTACCCAGACTAGAGATAG chr7 82476354 82476627PLCG2 TGACTCTTTTAGTTCCTCACGTACC CTGTGTATTTTAGTCCAAGGAATGCG chr16 81925065 81925339PLCG2 TTCGGTATTGAAAACGTGGGTAAC GTTATGTGACGAGGAGATCCAGTAA chr16 81924919 81925193PLCG2 CCTGTTAACTAAACCCCTTTCAGTACTA CATGATCACCTGGACGGTTCTC chr16 81819487 81819735PLCG2 GTCCCCAGAAGCTTACATCCG TTTACAATTCGAAAGAAAACATGGAGCA chr16 81927347 81927487PLCG2 CTACATGGAAGAACTCAGAGCTTTGG CCACATGGTTATCCTCAATTTGCTG chr16 81927184 81927458PLCG2 GTGGGTGTCCTTGTCTAGTAACTG CCTTCCCCTTTAAGTCACACCAC chr16 81929306 81929575PLCG2 CGCGGACTACCAAGATCAAGT GGGAGCAACTTGCACTCTCG chr16 81929463 81929736PLCG2 GTGATCCTGTCCATCGAGGAG CAGGCCCAGTAGGACATAGAACT chr16 81934224 81934486PLCG2 CACCCAGGATGAGGTCCTCTC GGCTTCGTCAACAGCAGGTC chr16 81934051 81934321PLCG2 AGAGGCAGATGAAGGCTGCT GCGTATTCTCAGAGCTCCCA chr16 81938927 81939199PLCG2 AAATGTCTATGAAACTGGGAAAAGCAC ACTTCCTCCTCCATAGTCTGTTCA chr16 81941162 81941372PLCG2 GGGCACTAATACCAGTTTCACTTTC GACATGGTACCCAGAGTATCAACAG chr16 81941262 81941530PLCG2 CTGTTTTCCCATACCCCTTCG CAGTATTCCTGCAGCAACTTCTCG chr16 81941867 81942115PLCG2 AGACCTTCCCCAATGACTACAC ggccTAGAAGAGCTAGACAAATGAA chr16 81942163 81942338PLCG2 CCAGGATATACCCCCTACAGAACTAC ATGGAGAAGAAGGTAGGCGTTC chr16 81942017 81942237PLCG2 GACTGACAACCTCACCTTCAGC CACCTCGGCAATTTTGAGATGC chr16 81944194 81944468PLCG2 GTTGTGTGGCCACATGTAATGT GTGCGTCTCGCGGTAGTG chr16 81944026 81944254
Supplementary Table 2: CLL Amplicons
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PLCG2 TGCCGCAGGTGGTACTATGA GGTGGTTGTTGTTGTCGCTGAT chr16 81946194 81946458PLCG2 CACTGTGTGATTTCCATGGTCGT TGAAGGTGATGGCATAGGAGTCG chr16 81946066 81946320PLCG2 CCACGGTCAATGTAGATTCCCTT CACAGTAATGACAAGACAGGAAGGTG chr16 81819602 81819876PLCG2 ggactataccctgtttatttacccactt GCGCAGTCTCATCTTTCGGTAG chr16 81952956 81953230PLCG2 GGGACCTCCGCCTATTTTGAGAG cagggtctttgttgtgctcaatttg chr16 81953147 81953421PLCG2 TCAAAGGATAGGTAACCATAAGGAAGC GTCTTCCCTTGCCCTGTTATAACT chr16 81954700 81954973PLCG2 AAGAACCAAATGGTACCTGGGAAC AGCACCTGAGTCTTATCACCAAGA chr16 81957004 81957275PLCG2 GGAGGGAACTCCAGCTTCTAATTG TGAGCATTCTGCTATTAGCGAACT chr16 81888003 81888273PLCG2 TAGGGTCTTAGCCCTTTGTCCATTT AGTCTTCTTTCTGGCGAACTGC chr16 81887865 81888135PLCG2 TGCAGATGAGCAGTAGTGGGTAAT CACAAGCAGCACATGGAAAAATTCA chr16 81960616 81960890PLCG2 ATAAAAAGACAGCAGTTGCCTTTGAG CTGCTTTTCTAGCTCCTCGAAGTC chr16 81960509 81960783PLCG2 GCACGTTTTTACGGATTGGAAAATG CTGCAAAGAGACCCTAAGGGATTG chr16 81961923 81962197PLCG2 AACGTGAGTTATGTCTTGTTTCTTCAC AGCAGACATAGCATCATACTCACTG chr16 81962134 81962408PLCG2 CTGGTCTTTGTGGCCCTCTAATAG TGTCAATCTTCCAGGTGATCTCTC chr16 81965043 81965254PLCG2 GAGGAGCTCTTTGAGTGGTTTCAG CTATCCCTGCCTCTCTCTAACAAGA chr16 81965200 81965442PLCG2 actgcaTCCCTTGAGTAGTCATCT GATGAAGACAAAGGACTTCTGGTTTTT chr16 81964912 81965145PLCG2 GGCACTAAAGACAGTGAACTCCAAA CTGGGAGTAGTTAAGAATGAGAGAATGC chr16 81968006 81968252PLCG2 TGTCTTCAGGAAAGGAAAACATTCAAC GGCATGTTCTTGGGAAAGATGTTAC chr16 81967887 81968161PLCG2 AAGTACAATCAAAAGGGCCTGACC AACCATTACTCTGCTGAACCGT chr16 81969857 81970130PLCG2 AATGTCAAAGAGGGAGATTCCTGGT GTCGTAGTTTGAAGAGTCAACTCTTTG chr16 81969651 81969925PLCG2 GGAGTTTGCTGTCTAGAAACCCTAT GCATCGGGTCATATTTCTCTGTCC chr16 81971190 81971464PLCG2 TCCCAGATAAGTACATGCAGATGAATC GGGATCGTTTAAACAAGACAACCAG chr16 81971357 81971631PLCG2 TCTCCCCAAACTTGGACGAAGTA CAGAAAGTGGCCCTTTGTATGTATC chr16 81972423 81972696PLCG2 ATGCTGAGGAACTGTGGGATCTA GCTCCACAGATCTCCACTTCTAC chr16 81972208 81972482PLCG2 CTGAAGGATGCGGAGATTGTCT TTAAAATGCCTCTTACCTGATTTGACTG chr16 81973420 81973680PLCG2 ACACAGGAGAAGGTGACATTTGAAATT ATCGGTTTTACAGTGATTCCATCCAA chr16 81973529 81973787PLCG2 TCTCTACCCTTTGAACTAGGCCTATG CAATTGTATTCACGGGCCGTT chr16 81979673 81979947PLCG2 AAGAACTGAACAACCAGCTCTTTCT GCCAAGGATTTCTGAAGAAAGCAAC chr16 81990352 81990603PLCG2 GCAATAAATCAACAGTGTAAAGACCAAG AGGAGGAGTAAAGTTCCTCTTCG chr16 81990064 81990327PLCG2 aTGGTTGTTCTCTCCCCTGCA CCCATCATCACCGTGCCTAG chr16 81990271 81990545PLCG2 CAGCCCTATACCATCCAGCTATGAA GAAAAGATGTCACAGATTAGCGTCTTC chr16 81991439 81991713PLCG2 ATAGGCTTCTCCCATCTTCGTGA CCTGTAGCCCATGTTGGCTAA chr16 81891766 81892039PLCG2 CTGCCCTTGTTAGAAAGTTGGAAGA CACCCCCTTGGAAGGTTTAAAGAT chr16 81892583 81892844PLCG2 GTTGAAAACCCTCAAGGTGACAGA CTCTGTCTGAACTAAGATGTACTCTGG chr16 81902773 81903047PLCG2 TGTTCCCAGTTAGTGGTCCATAAATAAC AGTCACTCCGCATTCATAAAATTCC chr16 81902676 81902950PLCG2 TGCCAATAAAATAGCATGCCATTTCT tcttagGAACATGCCAGACTTGGA chr16 81904345 81904617PLCG2 TGTGCTTTCCATTTCAGATTCTCG CCTGTTGCTACTGCTCATCTCTATC chr16 81914498 81914743PLCG2 GAATGAGGAGGGCTTCTACCTTTTG GATGAACACGGACGAATCCTTTTT chr16 81914315 81914553PLCG2 ACATTGTGTCACTCACCTGTGTC CTCACCTGCTGTTCATGTATGAGAA chr16 81916705 81916951
Supplementary Table 2: CLL Amplicons
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PLCG2 CCTTTCCCCGAGGATAGGAACA GCAATCTGAAGTCTCTGGCATCTG chr16 81916857 81917128PLCG2 AGTCTTCGATTGCGACTGGAT AAACAGAAAATAAACCTCAGAAAGCACA chr16 81922686 81922957POT1 TCATTTGGAAGCAAAGCTTTCAGACT GGACAAATTCTTCCAGATTCCAGCAT chr7 124465199 124465412POT1 GCACAAAAGGCTAGGGAACTATCAG AGGTTGGAAGCTTTCTTAGAATCTATAGC chr7 124492923 124493194POT1 ATTCTCTGAATTCATTGATTGAAGTTTGGT TTTAGTTTTGATGTAGTGTCCATGCAg chr7 124493130 124493382POT1 AGACTGTATCACCTATACATGTAACCAT GACACCATTTCCATCTTGGAGAGT chr7 124498905 124499149POT1 GCTGAAACATAAGCTCTTTACAGACATG TACCTCGCACTTCAAGCAAGTATT chr7 124503332 124503606POT1 AATGTCCAAGACGGTGACATATGA TCCAGTTTCTTTGGTTCGTAGGTT chr7 124503501 124503775POT1 TTCTTATCTCCTGAAAAGCTTGCTGT TTTGTGTTTTCCAGATTATTGCTCAGTT chr7 124510836 124511109POT1 AAATTATTGGAAGGGCTTCATAGTTTCC AATTTTGCAGTGTGTATTGAAAGCCAA chr7 124511003 124511263POT1 AATATGCATCAGTGTTGTTTGGCAAT TTCACTGTCTTCTCTTTCTTTAGGTTCC chr7 124532183 124532457POT1 ACCTACCAGTTCCTTTGCTTAGATATG TGTGTGCATTGCCTTATTTCAGGTTATA chr7 124532314 124532584POT1 ATGTGTGTGGCATATACAGGTATAGG AGCATGTAATCACATTGGAGGTTATCT chr7 124537158 124537327PTPN11_x13 TCTCTTTATTCTTCATGATGTTTCCTTCGT CCTGCTCAAAAGGAGAGCGTATC chr12 112926796 112927055PTPN11_x3 TGGTGTAACTCTTTATTTGTCCCCTT AAATGTTACTGACCTTTCAGAGGTAGG chr12 112888069 112888329PTPN11_x6 TGTACTCGATCAGCCCCTTAACA CAACTTGCTCCGTGTCAATCAAT chr12 112893741 112894015RIPK1 ATGTTTCATGACACCCATTCTAATGTTG CCTTTCCTCCTCTCTGTTGTAAGC chr6 3105673 3105942RIPK1 CTTTTGCACAGCAAAGACCTTACG GTCTCAGGCACTGGGATATTATGC chr6 3105965 3106232RIPK1 TCTGGTACTCTTCATTTCACTTGGG ACTTTTGGAGCATCTGGTAAACCTTT chr6 3113186 3113460RPS15 CAGGCGGGATCAGCTGAC ACCTCCTCACACCACGAA chr19 1440302 1440576RPS15_L33 GGGCCGCTCACAAAACTG CACCTTGATCTCCACCTGGTT chr19 1439981 1440255SAMHD1_I386 CTTCTTACCTGTCAGCTTAGTATAGGC CACAAATTTAGTACGGTGGAGAAGC chr20 35539613 35539887SAMHD1_I515 ccaggccCACTTTAATTGTAAAGATATG GTTCAGTTCTCCTGCTTGCTATATGA chr20 35526724 35526998SAMHD1_M1_R3 GGACCCCATGTCTTGTAGTCG GGCTGCCAATACTCCTTGGAC chr20 35579907 35580154SAMHD1_R226 TTTATAACACAGTAGTGGAACCAAACAGAT AGATGTTTTTCTTGTTCTAAGGCTGCT chr20 35555488 35555694SAMHD1_R290 attttaGCCAACTTTTCAGAAGTGTTCA ATCTCATATTCCCAGTCAGGTATCTGTT chr20 35545316 35545573SAMHD1_x15 ATTGTGCAAAGTTTGTGAGTAACAGG TAGGGACCAGCTGATATCTCCAATG chr20 35526191 35526429SAMHD1_x7 TCAGAAGGAATCATGAAAAGGCTAGATG CCAATGGGCTAGAATCTTTAACACATCA chr20 35547697 35547971SAMHD1_x9 TGGTTATTTCCAAATTTCAGACCAGGA ACAGCTTCCTTGTTGAAAAATTTCATCT chr20 35545060 35545283SAMHD1_Y360 TGTCTAGTTGAGCCTAGTATGATACTCT TCTTGTCTGCCACTATCCCTTTTC chr20 35540785 35541059SF3B1_x14 GACAGGCTGTGTGTGTAcct CAAAAGCAAGAAGTCCTGGCA chr2 198267127 198267401SF3B1_x14 GCACAGCCCATAAGAATAGCTATC CAACTCATGACTGTCCTTTCTTTGTT chr2 198267324 198267586SF3B1_x15_and16 ATTGGTGGATTTACCTTTCCTCTGTG ATGTGAACATATTCTGCAGTTTGGC chr2 198266695 198266969SF3B1_x15_and16 TTCTGTTAGAACCATGAAACATATCCAGTT CTGCTTTCTTGAAGGCTATTGGGT chr2 198266410 198266605SF3B1_x15_and16 AGTATAGTAGTTGGCATATTCTGCATCC TGAAGCAGCAACTCCTTATGGTAT chr2 198266538 198266793SF3B1_x18 AATAATATCGTTTGGTAACCCCCTGA ACAGTACAGAAAAATGGTGATGGAGAC chr2 198265297 198265571SF3B1_x18 ACCTCTGTAGTCTGTTCTTGGAAAG TTTCCTTGGAAAAGCAGTCTAAAAGGTT chr2 198265437 198265711SMC1A TGACTAATATCATCCATGGTGCCTTTT TGGAGGAGATTCGTAAGAAACTCG chrX 53423154 53423428TET2_rs2454206 AGACCAAATGTACATCATGTAGGGAAAT GCTGGAAGCATCTTTGATAACCC chr4 106196801 106197075
Supplementary Table 2: CLL Amplicons
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TET2_S1563_A1605 CCTCAGACAGAGTCTGTCAACTCTTA GAGCAGTTGTCCACTGATAGGTT chr4 106196321 106196595TET2_S1563_A1605 TCCACAGAACTTTTGCGACTTTC GATGAGGTGGAATAGAAGTTCATAGGG chr4 106196198 106196472TGM7_K31 CACAAAGGTGATGTGGTCGT cctcccAGAAATGACTGAGAAGC chr15 43585657 43585916TP53 GGGAATATTCAACTTTGGGACAGGAG CTTCTGTCCCTTCCCAGAAAACCTA chr17 7579132 7579403TP53 GGTCTTCAGTGAACCATTGTTCAA GAGACCTGTGGGAAGCGAAAATT chr17 7579515 7579777TP53 CAACTGACCGTGCAAGTCACA CCAAGCAATGGATGATTTGATGCTG chr17 7579304 7579576TP53 CTATTGCAAGCAAGGGTTCAAAGAC TCTCACTCATGTGATGTCATCTCTCC chr17 7572828 7573056TP53 GAAGTGGAGAATGTCAGTCTGAGT ACACTAATACTCTGAGGTGCTCAGT chr17 7572914 7573183TP53 CAGGAAGTCTGAAAGACAAGAGCAG CAGGGTTGGAAGTGTCTCATGC chr17 7579714 7579987TP53 AAGGCAGGATGAGAATGGAATCCTAT aaagtcaaacaattgtaacttgaaccatct chr17 7573843 7574117TP53 aaaaagcaggctaggctaagct CTCAAAGACAATGGCTCCTGG chr17 7576458 7576732TP53 CCAATTGCAGGTAAAACAGTCAAG AGGGAGCACTAAGCGAGGTAAG chr17 7576761 7577035TP53 CATAACTGCACCCTTGGTCTC GGAGTAGATGGAGCCTGGT chr17 7576969 7577243TP53 GCCACAGGTTAAGAGGTCCCAAA TACATGTGTAACAGTTCCTGCATGG chr17 7577301 7577575TP53 CAGTGTGCAGGGTGGCAA aaaaaGGCCTCCCCTGCTT chr17 7577469 7577683TP53 TCATCCAAATACTCCACACGCAAA AGCTGTGGGTTGATTCCACAC chr17 7578226 7578499TP53 ccatttactttgcacatctcatggg TGATTCCTCACTGATTGCTCTTAGG chr17 7578039 7578313TP53 TGACTGCTTGTAGATGGCCATG TCCTGAGGTGTAGACGCCAAC chr17 7578432 7578704XPO1_C585_D624 CTCCAACCTGAACCTGAACGAAA AGCTCACTGGAAATTTCTGAAGACTG chr2 61719241 61719515XPO1_E571_H574 CTCCAACCTGAACCTGAACGAAA AGCTCACTGGAAATTTCTGAAGACTG chr2 61719241 61719515XPO1_C585_D624 TGGATCCAATAGTTGCCCTCCTA GACCCATGATGGAGTCCAGGATAT chr2 61719075 61719332XPO1_D10 AAACCCAACAACTCTGTTACACTGT ATACCAAAACTTGATAGGCAGCTTCA chr2 61760848 61761085XPO1_E571_H574 TCATTTATTTTGTCCTGGACTCCATCA AGGATTATGTGAACAGAAAAGAGGCAA chr2 61719352 61719608XPO5 TTTTCTGACCTTTTGGGTTATGTAGAGA TTGTAGGCTAGAAATGAAATTCATGGGA chr6 43498383 43498653XPO5 ACAACAGAGAAAAGCCATTATTCTGACT AGATGAGCTTTTGTGTATACAGCATTCT chr6 43514277 43514491XPO5 TGGTAACTTACTTTTCTGCTGACTGC TGGGAGTTCAGTTATAACCACTGATT chr6 43534895 43535169ZMYM3 AGGACGACCCAGTTCCTCATAAAT GAGGGATCTACTTTGCCTTGGTAC chrX 70460787 70461033ZMYM3 GGACAGAAGATCAGTACCAAGGC CATGGAGCCTGTGTTCTTAATGAGT chrX 70460997 70461243ZMYM3 GACTGGCTGTTTCTACCCTTTCTG CATGCAACTCTCCTTCACCAATGT chrX 70461864 70462138ZMYM3 GAAACTCACCGGGATAGGCATC GCCTCATTCATATGGTTGTCCTAGAA chrX 70465827 70466101ZMYM3 GAAGCTCTGTCCTTGAATACGCT TTCCATGAGTTCTGCACATCCG chrX 70469725 70469998ZMYM3 CTCTAGGGTCTGATCTCCTGCATC GAGACCTACCAGTAGACATGGAATTT chrX 70472767 70473041
Supplementary Table 2: CLL Amplicons
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SampleID CHROM Symbol pos ref alt freq.100_Cells freq.300_Cells freq.50_Cells freq.500_Cells freq.Bulk_CellsCLL 22 chrX ZMYM3 70461898 CAG CAGAAG 0 0 0.75 0 0CLL 22 chr11 NXF1 62569105 TA TACA 0.491 0 0.602 0 0CLL 22 chr9 13995138 C T 0.652 0.555 0.235 0.527 0.539CLL 22 chr9 13995203 T C 0.648 0.558 0.233 0.527 0.538CLL 22 chr9 13995323 A G 0.641 0.551 0.234 0.52 0.533CLL 22 chr16 PLCG2 81964977 A G 0.255 0.538 0.566 0.496 0.456CLL 22 chr16 PLCG2 81941933 TGGG TGG 0.28 0 0.304 0 0CLL 22 chr9 NOTCH1 139391636 G A 0.374 0.652 0.729 0.556 0.532CLL 22 chr16 PLCG2 81946368 A C 0.489 0.574 0.714 0.48 0.465CLL 22 chr16 PLCG2 81941934 G C 0.761 0.692 0.727 0.794 0.59CLL 22 chr9 NOTCH1 139413908 C T 0.469 0.43 0.313 0.516 0.493CLL 22 chr16 PLCG2 81971403 T C 0.612 0.426 0.517 0.436 0.509CLL 22 chr16 PLCG2 81957303 T G 0.61 0.483 0.457 0.5 0.492CLL 22 chr7 PCLO 82451727 A G 0.187 0.124 0.154 0.095 0.003CLL 22 chr16 PLCG2 81962071 A C 0.575 0.429 0.428 0.446 0.425CLL 22 chr9 37371649 A G 0.474 0.403 0.418 0.488 0.549CLL 22 chr17 TP53 7578115 T C 0.343 0.33 0.474 0.365 0.378CLL 22 chr9 37371717 T A 0.494 0.417 0.414 0.494 0.551CLL 22 chr2 XPO1 61719472 C T 0.362 0.38 0.324 0.407 0.455CLL 22 chr16 CREBBP 3795363 G A 0.577 0.55 0.662 0.566 0.534CLL 22 chr2 SF3B1 198266862 A T 0.43 0.426 0.551 0.521 0.459CLL 22 chr2 XPO1 61719401 C T 0.014 0.015 0 0.14 0.018CLL 22 chr9 NOTCH1 139390676 A C 0.662 0.615 0.629 0.504 0.57CLL 22 chr17 TP53 7579801 G C 0.425 0.421 0.51 0.486 0.542CLL 22 chr15 MGA 42003140 C T 0.08 0.12 0.012 0.101 0CLL 22 chr6 HIST1H1E 26157171 C G 0.017 0.052 0 0.121 0.001CLL 22 chr17 TP53 7579472 G C 0.488 0.457 0.565 0.518 0.514CLL 22 chrX BTK 100613411 ACCCC ACCC 0.026 0 0.108 0 0CLL 22 chr2 SF3B1 198267212 T G 0.043 0.083 0 0.108 0.001CLL 22 chr17 TP53 7578146 T C 0.471 0.484 0.388 0.43 0.442CLL 22 chr21 DYRK1A 38862711 G C 0.096 0.112 0.175 0.094 0.085CLL 22 chr20 SAMHD1 35539660 T C 0.032 0.044 0.01 0.085 0.001CLL 22 chr2 SF3B1 198265619 T A 0 0.032 0.013 0.081 0.001CLL 22 chr2 XPO1 61719522 A G 0.07 0.079 0.024 0.019 0.001
Supplementary Table 3: CLL Cell Titrations
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CLL 22 chr2 DNMT3A 25498281 C T 0 0 0.077 0 0.001CLL 22 chr16 PLCG2 81957337 C T 0.597 0.463 0.562 0.538 0.51CLL 22 chr17 TP53 7579805 G A 0.072 0 0 0.001 0CLL 22 chr7 PCLO 82451597 A G 0.048 0.071 0 0.027 0.001CLL 22 chr20 SAMHD1 35544987 A G 0.103 0.07 0 0.034 0.002CLL 22 chr1 NRAS 115256523 T C 0.111 0.063 0 0.07 0.004CLL 22 chr2 XPO1 61719503 T A 0.031 0.066 0.009 0.023 0CLL 22 chr20 SAMHD1 35545122 T C 0.091 0.038 0 0.068 0.004CLL 22 chr9 NOTCH1 139390397 C T 0.561 0.512 0.708 0.575 0.527CLL 22 chr2 XPO1 61719507 C A 0.031 0.063 0.009 0.023 0.001CLL 22 chr7 PCLO 82451681 A G 0.021 0.046 0.01 0.062 0.001CLL 22 chr7 PCLO 82451683 A G 0.022 0.043 0.01 0.062 0.001CLL 22 chr12 KRAS 25398220 A G 0.073 0.062 0.019 0.043 0.003CLL 22 chr7 BRAF 140481382 A T 0.038 0.059 0.037 0.05 0CLL 22 chr2 SF3B1 198265518 C T 0 0.038 0.012 0.06 0.003CLL 22 chr2 XPO1 61719496 T G 0.044 0.057 0.008 0.004 0.001CLL 22 chr1 NRAS 115256636 G A 0 0.012 0 0.061 0.007CLL 22 chr16 CREBBP 3843468 C T 0.032 0.055 0 0.016 0.001CLL 22 chr16 PLCG2 81892694 T A 0 0.054 0.014 0.022 0CLL 22 chr7 POT1 124532442 A G 0.057 0.012 0 0.003 0.006CLL 22 chr7 PCLO 82451893 G A 0.035 0.057 0 0.011 0.003CLL 22 chr17 TP53 7579258 G A 0.009 0.042 0 0.053 0.001CLL 22 chr1 NRAS 115256669 G A 0.417 0.408 0.294 0.459 0.425CLL 22 chr12 KRAS 25398325 C T 0 0 0.052 0.002 0.001CLL 22 chr20 SAMHD1 35545170 A C 0.031 0.033 0 0.05 0CLL 22 chr6 XPO5 43498314 T C 0.049 0.001 0 0 0.002CLL 22 chr1 FUBP1 78430485 T C 0.048 0.009 0 0 0CLL 22 chr11 NXF1 62569134 T A 0.027 0.048 0.013 0.045 0CLL 22 chr1 FUBP1 78430019 A G 0.115 0.049 0.018 0.029 0.002CLL 22 chr11 NXF1 62567636 C T 0.727 0.556 0.727 0.535 0.51CLL 22 chr12 BAZ2A 57000162 CAAAAA CAAAA 0.094 0 0.044 0 0CLL 22 chr12 BAZ2A 57000163 A C 0.025 0.04 0.007 0.048 0.004CLL 22 chr16 PLCG2 81916736 G A 0.044 0 0 0 0CLL 22 chr2 BIRC6 32688305 T A 0.031 0.045 0.025 0.01 0.001CLL 22 chr4 TET2 106197000 A G 0.461 0.454 0.484 0.498 0.48
Supplementary Table 3: CLL Cell Titrations
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CLL 22 chr9 NOTCH1 139390744 T C 0 0 0.046 0.002 0.002CLL 22 chr9 NOTCH1 139405093 G A 0.649 0.578 0.529 0.598 0.556CLL 22 chr3 KLHL6 183245823 A T 0.041 0.009 0 0.005 0CLL 22 chr16 PLCG2 81922931 G T 0.038 0.041 0 0.01 0.001CLL 22 chr20 SAMHD1 35545107 T C 0.061 0.041 0 0.043 0.003CLL 22 chr6 XPO5 43514357 A T 0 0.041 0.019 0.021 0.001CLL 22 chr7 BRAF 140477781 A T 0.025 0.028 0.047 0.008 0.014CLL 22 chr7 PCLO 82451695 A G 0 0.009 0.01 0.039 0CLL 22 chrX BTK 100630143 A G 0.006 0.028 0.007 0.041 0.002CLL 22 chr1 NRAS 115256539 T G 0 0.005 0 0.037 0CLL 22 chr16 PLCG2 81973631 C A 0 0 0.037 0 0CLL 22 chr6 XPO5 43514214 C G 0 0.037 0 0.033 0CLL 22 chr7 POT1 124503602 A G 0.038 0.001 0.005 0.001 0.002CLL 22 chrX DDX3X 41204699 G A 0.038 0.033 0.019 0.011 0.001CLL 22 chr12 BAZ2A 56995322 C A 0.036 0 0 0 0CLL 22 chr15 MGA 41988282 C T 0 0 0.036 0 0CLL 22 chr16 PLCG2 81941319 C T 0.551 0.552 0.418 0.553 0.517CLL 22 chr17 TP53 7573837 A G 0.003 0.001 0.036 0.002 0.001CLL 22 chr16 PLCG2 81957109 C G 0.027 0.035 0.009 0.018 0.001CLL 22 chr16 PLCG2 81957111 C T 0.027 0.035 0.009 0.017 0.001CLL 22 chr6 HIST1H1E 26157076 A G 0.038 0.035 0 0.01 0.002CLL 22 chr17 TP53 7578504 A G 0 0.003 0.033 0.001 0.001CLL 22 chr2 BIRC6 32696064 G C 0.033 0.011 0 0.007 0.001CLL 22 chr12 PTPN11 112888240 G A 0 0.001 0.031 0 0.001CLL 22 chrX BTK 100613228 C T 0.033 0.013 0.011 0.004 0.003CLL 22 chr11 NXF1 62569281 A G 0 0 0.029 0 0.002CLL 22 chr16 PLCG2 81922757 G A 0.03 0.023 0 0.019 0.001CLL 22 chr2 SF3B1 198267222 A C 0.017 0.029 0 0.029 0CLL 22 chr2 BIRC6 32713059 T A 0.971 0.956 0.954 0.964 0.982CLL 22 chr9 NOTCH1 139404895 C T 0.611 0.524 0.327 0.552 0.546CLL 22 chr16 PLCG2 81941444 C T 0.542 0.569 0.4 0.571 0.543CLL 22 chr2 BIRC6 32713061 A T 0.971 0.956 0.954 0.963 0.981CLL 22 chr7 POT1 124511009 T C 0 0.029 0.018 0.028 0.002CLL 22 chr7 POT1 124532427 G A 0.029 0.007 0.008 0.003 0.002CLL 22 chr7 BRAF 140453970 A G 0.019 0.03 0 0.031 0.004
Supplementary Table 3: CLL Cell Titrations
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CLL 22 chrX DDX3X 41204663 G C 0 0.023 0.007 0.027 0CLL 22 chr2 SF3B1 198267001 C T 0.027 0.01 0.007 0.004 0.001CLL 22 chrX BTK 100604842 A G 0.006 0.013 0.028 0.004 0.002CLL 22 chr7 BRAF 140481377 A C 0 0.024 0.019 0.012 0CLL 22 chr3 MYD88 38182502 T G 0.02 0.023 0.017 0.009 0.001CLL 22 chr6 RIPK1 3106153 G T 0.008 0.022 0.016 0.008 0CLL 22 chr15 MGA 41961195 A G 0.014 0.022 0.003 0.008 0.001CLL 22 chr17 TP53 7577196 A G 0.016 0.022 0 0.015 0.001CLL 22 chr9 NOTCH1 139404988 C T 0.607 0.526 0.446 0.547 0.542CLL 22 chr17 TP53 7578134 A T 0.021 0.01 0 0.008 0.001CLL 22 chr16 PLCG2 81922736 T C 0 0.019 0.01 0.021 0.002CLL 22 chrX DDX3X 41204660 C T 0 0.021 0.007 0.026 0CLL 22 chr1 FUBP1 78425884 C T 0 0.012 0 0.018 0CLL 22 chr16 PLCG2 81924883 A G 0.1 0.019 0 0.004 0.001CLL 22 chrX BTK 100629537 T C 0.019 0.007 0 0.002 0.001CLL 22 chr12 BAZ2A 56999649 T C 0.017 0.004 0 0.002 0CLL 22 chr2 BIRC6 32696060 CTTT CTT 0.017 0 0 0 0CLL 22 chr2 BIRC6 32696060 C T 0.017 0.001 0 0.001 0.001CLL 22 chr6 RIPK1 3106087 C A 0.016 0.006 0 0.004 0CLL 22 chr7 PCLO 82595759 T G 0 0.018 0 0.003 0.002CLL 22 chrX BTK 100626724 A G 0 0.018 0.01 0.017 0.002CLL 22 chr1 NRAS 115256636 GAA GAAA 0 0 0 0 0.015CLL 22 chr11 NXF1 62569304 C G 0 0.011 0.002 0.015 0CLL 22 chr2 BIRC6 32696062 T C 0.016 0.004 0.012 0.002 0.001CLL 22 chr2 BIRC6 32713061 A AT 0 0 0.015 0 0CLL 22 chr9 37371644 C T 0.015 0.017 0.007 0.01 0.002CLL 22 chrX BTK 100612574 GAAA GAA 0.031 0 0.014 0 0CLL 22 chr16 PLCG2 81941934 G T 0.013 0.004 0 0.003 0.003CLL 22 chrX DDX3X 41203410 T C 0 0.019 0 0.013 0.006CLL 22 chr1 FUBP1 78430019 A AT 0 0 0.012 0 0CLL 22 chr16 PLCG2 81904375 CAAAAA CAAAA 0.012 0 0 0 0CLL 22 chr16 PLCG2 81914574 T A 0.04 0.014 0.04 0.008 0.002CLL 22 chr15 MGA 41988432 T G 0.011 0.009 0 0.005 0CLL 22 chr16 CREBBP 3795158 C A 0 0.012 0 0.005 0.001CLL 22 chr16 PLCG2 81922924 G C 0.014 0.018 0 0.007 0
Supplementary Table 3: CLL Cell Titrations
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CLL 22 chr11 NXF1 62569279 T G 0.004 0.01 0.002 0.009 0CLL 22 chr17 TP53 7577188 A T 0.008 0.01 0 0.006 0CLL 22 chr20 SAMHD1 35539858 C G 0.963 0.989 0.994 0.994 0.999CLL 22 chr7 POT1 124492951 C A 0.002 0.004 0 0.01 0CLL 22 chrX BTK 100604757 T TG 0.021 0 0.01 0 0CLL 22 chr20 SAMHD1 35545494 C G 0.028 0.006 0 0.008 0CLL 22 chr2 SF3B1 198266943 C T 1 0.998 0.993 0.999 0.999CLL 22 chrX BTK 100604757 T G 0.989 0.993 1 0.994 0.997CLL 22 chr12 BAZ2A 56999761 T C 0 0.005 0.015 0.001 0CLL 22 chr16 PLCG2 81953081 T C 1 0.994 1 0.995 0.999CLL 22 chr16 PLCG2 81914583 C T 1 0.994 0.96 0.998 0.997CLL 22 chr16 PLCG2 81954789 C T 0.052 0.006 0 0.006 0.01CLL 22 chr2 SF3B1 198265526 A G 0.952 0.996 1 1 0.999CLL 22 chr12 CCND2 4383158 T C 1 0.997 1 0.997 0.997CLL 22 chr16 PLCG2 81914583 C G 0 0.004 0.04 0.001 0.001CLL 22 chr16 PLCG2 81941444 C G 0 0 0.014 0 0.002CLL 22 chr20 ASXL1 31022959 T C 1 0.999 1 0.999 0.998CLL 22 chr7 POT1 124532331 C G 0.011 0.001 0 0.003 0.001CLL 22 chrX BTK 100609547 G A 1 0.998 1 1 0.998CLL 22 chrX FAM50A 153678587 T A 0 0 0.01 0.002 0CLL 22 chr15 MGA 42026764 C T 1 1 1 1 0.999CLL 22 chr15 MGA 42041712 G A 1 1 1 1 0.999CLL 22 chr16 PLCG2 81954789 C G 0 0.001 0.011 0 0CLL 22 chr16 PLCG2 81973474 C A 1 1 1 1 0.999CLL 22 chr2 BIRC6 32712875 A C 1 1 1 1 0.999CLL 22 chr16 PLCG2 81939150 G C 1 1 1 1 1CLL 22 chr16 PLCG2 81954789 CTTTTTTTTT CTTTTTTT 0 0 0.011 0 0CLL 22 chr16 PLCG2 81954789 CTTTTTTTTT CTTTTTTTT 0.431 0 0.367 0 0CLL 22 chr16 PLCG2 81954789 CTTTTTTTTT CTTTTTTTTTT 0 0 0.022 0 0CLL 22 chr2 SF3B1 198265526 A C 0.048 0 0 0 0CLL 22 chr2 SF3B1 198265619 T TC 0 0 0.013 0 0CLL 22 chr2 BIRC6 32696060 CTTT CTTTT 0 0 0.012 0 0CLL 22 chr2 BIRC6 32696068 TC T 0 0 0.012 0 0CLL 22 chr6 HIST1H1E 26157171 C T 0.017 0 0 0 0CLL 22 chr9 NOTCH1 139404988 C CT 0 0 0.011 0 0
Supplementary Table 3: CLL Cell Titrations
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CLL 22 chrX DDX3X 41203353 C T 0 0.001 0.017 0.001 0.001CLL 23 chr9 NOTCH1 139391636 G A 0.598 0.453 0.928 0.49 0.493CLL 23 chr9 PAX5 37034095 C T 0.467 0.554 0.566 0 0.132CLL 23 chr16 PLCG2 81941444 C T 0.631 0.499 0.753 0.454 0.52CLL 23 chr16 PLCG2 81954789 C G 0.299 0.385 0.199 0.467 0.414CLL 23 chr16 PLCG2 81929488 C T 0.413 0.466 0.668 0.512 0.493CLL 23 chr17 TP53 7579801 G C 0.546 0.46 0.667 0.426 0.515CLL 23 chr16 PLCG2 81972497 A C 0.567 0.532 0.666 0.433 0.505CLL 23 chr1 FUBP1 78430019 A G 0.003 0.003 0.004 0.227 0.004CLL 23 chr20 SAMHD1 35539660 T C 0.002 0.001 0.001 0.222 0.002CLL 23 chr4 TET2 106196829 T G 0.672 0.552 0.451 0.508 0.489CLL 23 chr4 TET2 106196951 A G 0.323 0.445 0.543 0.518 0.489CLL 23 chr15 MGA 42041712 G A 0.313 0.532 0.513 0.455 0.467CLL 23 chr17 TP53 7579472 G C 0.518 0.446 0.656 0.464 0.493CLL 23 chrX BTK 100604757 T G 0.68 0.551 0.536 0.612 0.47CLL 23 chr17 TP53 7578115 T C 0.429 0.478 0.638 0.5 0.466CLL 23 chr12 BAZ2A 57000163 A C 0.002 0.001 0.002 0.207 0.001CLL 23 chr3 KLHL6 183273129 C G 0.437 0.556 0.35 0.528 0.502CLL 23 chr16 PLCG2 81957303 T G 0.486 0.597 0.551 0.395 0.49CLL 23 chr16 PLCG2 81971403 T C 0.539 0.598 0.656 0.541 0.477CLL 23 chr15 MGA 42003140 C T 0.004 0.003 0.004 0.18 0.002CLL 23 chr6 HIST1H1E 26157171 C G 0.001 0.001 0 0.17 0.001CLL 23 chr16 PLCG2 81914583 C T 0.597 0.449 0.509 0.434 0.486CLL 23 chr2 SF3B1 198267212 T G 0.001 0.001 0.001 0.158 0.001CLL 23 chr15 MGA 42026764 C T 0.443 0.569 0.596 0.484 0.477CLL 23 chr2 SF3B1 198265526 A G 0.627 0.476 0.536 0.409 0.509CLL 23 chr20 SAMHD1 35545122 T C 0.005 0.01 0.009 0.153 0.004CLL 23 chr12 CCND2 4409144 C T 0.086 0.167 0.184 0.22 0.217CLL 23 chr12 KRAS 25398220 A G 0.001 0.002 0.002 0.129 0.003CLL 23 chr7 PCLO 82451558 T G 0.419 0.444 0.547 0.574 0.487CLL 23 chr16 PLCG2 81934047 T C 0.463 0.525 0.521 0.398 0.439CLL 23 chr16 PLCG2 81902990 G A 0.597 0.474 0.598 0.472 0.483CLL 23 chrX DDX3X 41203410 T C 0.002 0.005 0.007 0.122 0.009CLL 23 chr9 37371644 C T 0.004 0.001 0.004 0.12 0.005CLL 23 chr16 PLCG2 81819768 T C 0.563 0.544 0.447 0.492 0.488
Supplementary Table 3: CLL Cell Titrations
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CLL 23 chr7 BRAF 140454087 G A 0.461 0.405 0.468 0.521 0.516CLL 23 chr7 PCLO 82451727 A G 0.003 0.005 0.006 0.117 0.003CLL 23 chr3 MYD88 38182087 C T 0.107 0.001 0 0 0.001CLL 23 chrX BTK 100630143 A G 0.001 0.001 0.001 0.101 0.001CLL 23 chr2 XPO1 61719522 A G 0.002 0.002 0.002 0.096 0.001CLL 23 chr7 PCLO 82451681 A G 0.002 0.001 0.003 0.096 0.003CLL 23 chr7 PCLO 82451683 A G 0.002 0.001 0.002 0.095 0.002CLL 23 chrX NLGN3 70388664 G A 0.069 0.068 0.047 0 0.141CLL 23 chrX BTK 100609547 G A 0.461 0.473 0.383 0.394 0.475CLL 23 chr2 XPO1 61719401 C T 0.002 0.002 0.001 0.091 0.015CLL 23 chr15 MGA 41988432 T G 0.002 0.001 0.001 0.085 0.001CLL 23 chr16 PLCG2 81819820 G A 0.56 0.559 0.569 0.521 0.491CLL 23 chr2 BIRC6 32696064 G C 0.002 0.001 0 0.077 0CLL 23 chr17 TP53 7577196 A G 0.004 0.001 0.001 0.077 0.004CLL 23 chr7 POT1 124511009 T C 0.001 0.001 0.001 0.077 0.001CLL 23 chr7 PCLO 82451695 A G 0.002 0.001 0.001 0.077 0.002CLL 23 chr16 PLCG2 81922736 T C 0 0.001 0.001 0.071 0.002CLL 23 chr20 SAMHD1 35545170 A C 0 0.001 0 0.071 0.001CLL 23 chr7 PCLO 82451893 G A 0.005 0.002 0.007 0.072 0.002CLL 23 chr16 PLCG2 81944151 G A 0 0.001 0.065 0 0CLL 23 chr9 NOTCH1 139391738 G A 0.065 0 0 0 0CLL 23 chr9 37371998 C T 0.063 0 0 0 0CLL 23 chr2 BIRC6 32688305 T A 0 0 0 0.059 0.002CLL 23 chrX BTK 100604842 A G 0.001 0.001 0.007 0.06 0.002CLL 23 chr12 BAZ2A 56999675 T C 0.001 0.001 0.058 0 0.001CLL 23 chr7 BRAF 140477781 A T 0.003 0.001 0.004 0.058 0.022CLL 23 chr11 NXF1 62569134 T A 0 0.002 0.001 0.056 0.002CLL 23 chrX BTK 100629537 T C 0 0.001 0.001 0.056 0.003CLL 23 chr12 BAZ2A 57000162 CAAAAA CAAAA 0 0 0 0.055 0CLL 23 chr2 SF3B1 198267001 C T 0.001 0.002 0 0.054 0.002CLL 23 chr11 NXF1 62569304 C G 0 0 0 0.053 0CLL 23 chr12 BAZ2A 56999871 A G 0.002 0.001 0.054 0 0.001CLL 23 chr7 PCLO 82451684 A G 0.001 0.001 0 0.051 0CLL 23 chr16 CREBBP 3795158 C A 0.002 0 0.003 0.052 0.002CLL 23 chr16 PLCG2 81914663 T C 0.001 0.001 0.051 0 0
Supplementary Table 3: CLL Cell Titrations
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CLL 23 chr7 BRAF 140481368 AT A 0 0 0 0.05 0CLL 23 chrX DDX3X 41204663 G C 0 0.001 0.001 0.05 0CLL 23 chr1 FUBP1 78429916 A C 0 0 0 0.049 0CLL 23 chr3 KLHL6 183245823 A T 0.001 0.002 0 0.048 0.001CLL 23 chr7 POT1 124492951 C A 0.001 0.001 0.001 0.049 0.001CLL 23 chr12 BAZ2A 56999812 T C 0.002 0.001 0 0.048 0.001CLL 23 chr2 XPO1 61719496 T G 0.001 0.001 0.001 0.048 0.003CLL 23 chr3 MYD88 38182502 T G 0.003 0.002 0.003 0.048 0.001CLL 23 chr16 PLCG2 81991505 G A 0 0 0.046 0 0.001CLL 23 chrX DDX3X 41204660 C T 0 0.001 0.001 0.046 0.001CLL 23 chr1 FUBP1 78432590 T C 0.005 0.003 0.048 0 0CLL 23 chr7 POT1 124532442 A G 0.001 0.002 0.003 0.046 0.007CLL 23 chr15 MGA 42003527 A G 0 0 0.043 0 0CLL 23 chr16 PLCG2 81891980 T C 0.001 0 0.043 0 0.001CLL 23 chr16 PLCG2 81957109 C G 0.002 0.001 0.002 0.043 0CLL 23 chr22 EWSR1 29696147 A G 0 0 0.043 0 0.001CLL 23 chr15 MGA 41988427 A G 0.001 0.002 0.002 0.043 0.002CLL 23 chr16 PLCG2 81957111 C T 0.002 0.001 0.002 0.043 0.001CLL 23 chr17 TP53 7577188 A T 0.001 0 0.001 0.042 0.001CLL 23 chr17 TP53 7578134 A T 0 0 0.001 0.042 0.001CLL 23 chr20 SAMHD1 35544987 A G 0.004 0.005 0.005 0.043 0.001CLL 23 chr20 SAMHD1 35545107 T C 0.004 0.001 0.001 0.042 0CLL 23 chr16 PLCG2 81922931 G T 0 0.001 0 0.041 0.001CLL 23 chr16 PLCG2 81934408 T C 0.001 0 0.041 0.001 0.001CLL 23 chr2 SF3B1 198267222 A C 0.001 0 0 0.041 0CLL 23 chrX BTK 100608301 G A 0.041 0.001 0 0.002 0CLL 23 chr2 BIRC6 32695918 T C 0.001 0.001 0.003 0.041 0.004CLL 23 chr7 BRAF 140481382 A T 0.002 0.003 0.005 0.04 0CLL 23 chrX BTK 100629533 T C 0 0.002 0.001 0.04 0.001CLL 23 chr2 BIRC6 32713059 T A 0.961 0.961 0.962 0.949 0.988CLL 23 chr3 MYD88 38182771 G A 0.039 0 0 0 0.001CLL 23 chr9 37371652 C A 0 0.001 0.002 0.039 0.001CLL 23 chrX BTK 100611970 T C 0.039 0 0.001 0 0.001CLL 23 chrX BTK 100613330 T C 0.001 0 0.039 0 0.001CLL 23 chr16 PLCG2 81914574 T A 0.001 0.005 0.001 0.039 0.006
Supplementary Table 3: CLL Cell Titrations
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CLL 23 chr9 13995177 A G 0 0 0.038 0 0CLL 23 chr2 BIRC6 32713061 A T 0.958 0.958 0.958 0.95 0.987CLL 23 chr1 FUBP1 78425884 C T 0.002 0 0.001 0.036 0CLL 23 chr1 FUBP1 78428629 A G 0.001 0.001 0.037 0 0.002CLL 23 chr20 ASXL1 31021424 G A 0 0 0.001 0.036 0.001CLL 23 chr16 PLCG2 81957043 C T 0.001 0.001 0.001 0.035 0CLL 23 chr2 BIRC6 32696062 T C 0.003 0.001 0.002 0.036 0.001CLL 23 chr2 BIRC6 32696068 T C 0.001 0.001 0.004 0.036 0.004CLL 23 chr9 13995096 T G 0 0 0.035 0 0CLL 23 chrX BTK 100615533 A G 0 0.003 0.036 0 0.001CLL 23 chr15 MGA 41961195 A G 0.001 0 0.002 0.034 0.001CLL 23 chr17 TP53 7573847 C T 0.034 0 0 0 0CLL 23 chr3 MYD88 38182742 T C 0.034 0.001 0 0 0.001CLL 23 chr6 RIPK1 3106076 C A 0 0 0 0.034 0.001CLL 23 chr11 NXF1 62567368 A C 0.033 0 0 0 0CLL 23 chr12 BAZ2A 56999761 T C 0.004 0 0.003 0.033 0CLL 23 chr20 ASXL1 31023122 T C 0 0 0.033 0.003 0.002CLL 23 chr9 NOTCH1 139391605 T C 0 0 0.033 0 0.001CLL 23 chr9 37369496 C T 0 0 0.033 0 0CLL 23 chr11 NXF1 62569279 T G 0 0 0 0.032 0CLL 23 chr15 MGA 42005357 C T 0 0 0.032 0 0.001CLL 23 chr20 SAMHD1 35540901 C T 0 0.032 0 0 0CLL 23 chr7 BRAF 140453129 A G 0.001 0 0.033 0 0.001CLL 23 chr9 NOTCH1 139390344 T C 0.033 0.001 0.008 0 0.003CLL 23 chrX DDX3X 41204699 G A 0.001 0.001 0.002 0.033 0.001CLL 23 chr12 PTPN11 112926896 C A 0 0 0.031 0 0CLL 23 chr15 MGA 42028659 G A 0 0 0.031 0 0CLL 23 chr16 PLCG2 81888059 G A 0.031 0 0 0 0CLL 23 chr16 PLCG2 81922924 G C 0 0.001 0 0.031 0CLL 23 chr16 PLCG2 81964998 A G 0 0 0.031 0 0.001CLL 23 chr17 TP53 7579258 G A 0.002 0.002 0.002 0.032 0.001CLL 23 chr6 RIPK1 3113346 C A 0.001 0 0.001 0.031 0.001CLL 23 chrX BTK 100626724 A G 0 0.002 0.001 0.031 0.001CLL 23 chr1 FUBP1 78428419 T C 0.002 0.001 0.031 0 0.002CLL 23 chr17 TP53 7577180 C G 0 0 0 0.03 0.001
Supplementary Table 3: CLL Cell Titrations
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CLL 23 chr7 POT1 124532331 C G 0.001 0 0 0.03 0.002CLL 23 chr7 BRAF 140453970 A G 0.002 0.001 0.002 0.031 0.002CLL 23 chr10 EGR2 64572943 T C 0.001 0.001 0.029 0.001 0CLL 23 chr12 PTPN11 112893901 G A 0.029 0 0 0 0.001CLL 23 chr12 BAZ2A 56999839 T G 0.001 0.001 0 0.03 0.005CLL 23 chr9 13995223 A G 0 0.002 0.029 0 0CLL 23 chr12 BAZ2A 56999649 T C 0 0 0.002 0.028 0.003CLL 23 chr16 PLCG2 81902871 A G 0 0.001 0.028 0 0.002CLL 23 chr22 CHEK2 29091785 A G 0.001 0 0.028 0 0CLL 23 chr22 CHEK2 29095787 A G 0.002 0.001 0.029 0 0.004CLL 23 chrX ZMYM3 70461867 T C 0.028 0 0 0 0.001CLL 23 chr16 PLCG2 81925015 A G 0.029 0.002 0 0 0.002CLL 23 chr16 PLCG2 81922757 G A 0 0 0.001 0.025 0CLL 23 chr16 PLCG2 81922790 A G 0.001 0 0.026 0 0.002CLL 23 chr1 NRAS 115256550 T C 0 0.011 0.024 0.051 0CLL 23 chr6 RIPK1 3106153 G T 0.001 0.001 0.001 0.024 0CLL 23 chr6 RIPK1 3106087 C A 0 0 0 0.022 0CLL 23 chr7 BRAF 140481377 A C 0 0 0 0.022 0.002CLL 23 chr9 37371644 C A 0.002 0 0 0.022 0CLL 23 chr17 TP53 7579395 G A 0 0 0.001 0.021 0.001CLL 23 chr7 BRAF 140481377 A G 0.001 0.001 0.002 0.022 0.001CLL 23 chr16 PLCG2 81892961 C A 0.005 0.021 0.013 0 0.001CLL 23 chr16 PLCG2 81967975 C A 0.001 0 0 0.019 0.001CLL 23 chrX MED12 70339138 T C 0 0.001 0.02 0 0.001CLL 23 chrX NLGN3 70388597 G A 0.037 0.037 0.026 0 0.045CLL 23 chr1 FUBP1 78430019 A AT 0 0 0 0.018 0CLL 23 chr16 PLCG2 81914582 T C 0.001 0.002 0 0.019 0.001CLL 23 chr1 NRAS 115256631 G A 0.02 0.003 0.009 0 0.01CLL 23 chr9 NOTCH1 139404962 TCCCCC TCCCCCC 0 0 0 0.017 0CLL 23 chr12 BAZ2A 57000162 C T 0 0 0.001 0.016 0.001CLL 23 chr1 NRAS 115256623 G A 0.013 0.006 0.003 0 0.018CLL 23 chr1 NRAS 115256636 GAA GAAA 0 0 0 0 0.015CLL 23 chr7 POT1 124532427 G A 0.001 0 0.001 0.015 0.002CLL 23 chrX BTK 100613228 C T 0.002 0.002 0.002 0.015 0.001CLL 23 chr16 PLCG2 81954789 C T 0.022 0.023 0.016 0.022 0.029
Supplementary Table 3: CLL Cell Titrations
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CLL 23 chrX BTK 100624820 T A 0.012 0.014 0.017 0.588 0.004CLL 23 chr2 SF3B1 198267001 C G 0 0.001 0 0.012 0CLL 23 chr6 HIST1H1E 26157076 A G 0.002 0.001 0.001 0.013 0.001CLL 23 chr16 PLCG2 81960659 C G 0.001 0 0.011 0 0CLL 23 chrX NLGN3 70388722 A G 0.003 0.012 0.001 0.25 0.004CLL 23 chr1 NRAS 115256523 T C 0.012 0.002 0.003 0.048 0CLL 23 chr1 NRAS 115256550 TCC TC 0 0 0 0 0.01CLL 23 chr7 POT1 124503435 GCT GT 0 0 0 0.01 0CLL 23 chrX BTK 100626724 AT ATT 0 0 0 0.01 0CLL 23 chr1 NRAS 115256585 T G 0 0.003 0.008 0 0.012CLL 23 chr12 BAZ2A 56993714 C T 0.987 0.994 0.986 0.994 0.994CLL 23 chr1 NRAS 115256585 T C 0 0 0.008 0.031 0CLL 23 chr16 PLCG2 81904375 C T 0.023 0.023 0.021 0.016 0.023CLL 23 chr16 PLCG2 81904375 C A 0.977 0.977 0.979 0.982 0.976CLL 23 chr16 PLCG2 81924883 A G 0.003 0.002 0 0.057 0.008CLL 23 chr1 NRAS 115256636 G A 0.004 0.005 0 0.01 0CLL 23 chr12 CCND2 4383158 T C 0.998 0.996 0.995 0.993 0.996CLL 23 chr2 SF3B1 198265518 C T 0.001 0.002 0.002 0.175 0.005CLL 23 chr20 ASXL1 31022959 T C 0.996 0.998 0.998 1 0.999CLL 23 chr7 PCLO 82586054 G A 0.005 0.001 0.003 0.138 0.002CLL 23 chr16 PLCG2 81902797 A G 1 0.998 0.999 1 1CLL 23 chr16 PLCG2 81941319 C T 0.999 0.998 0.999 1 0.998CLL 23 chr16 PLCG2 81953081 T C 0.995 0.995 0.994 1 0.996CLL 23 chr16 PLCG2 81962071 A C 1 0.998 0.999 1 1CLL 23 chr2 SF3B1 198265619 T A 0.001 0.001 0.003 0.112 0.003CLL 23 chr2 SF3B1 198266943 C T 0.999 0.999 0.999 0.997 0.999CLL 23 chr2 XPO1 61719503 T A 0.001 0 0.001 0.068 0.002CLL 23 chr20 SAMHD1 35539858 C G 0.999 0.999 0.998 1 0.999CLL 23 chr6 XPO5 43514357 A T 0 0.001 0.002 0.035 0.002CLL 23 chr7 PCLO 82451597 A G 0.002 0.001 0.001 0.06 0CLL 23 chr7 PCLO 82595759 T C 0.003 0.002 0.003 0.022 0.004CLL 23 chr7 PCLO 82595759 T G 0.002 0.002 0.002 0.043 0CLL 23 chrX DDX3X 41203119 G A 0.996 0.996 0.997 0.996 0.998CLL 23 chr16 PLCG2 81892694 T A 0 0.001 0.001 0.113 0.001CLL 23 chr16 PLCG2 81939150 G C 1 0.999 1 1 1
Supplementary Table 3: CLL Cell Titrations
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CLL 23 chr2 BIRC6 32712875 A C 0.998 0.999 0.999 0.999 0.999CLL 23 chr2 XPO1 61719507 C A 0.001 0.001 0.001 0.064 0.002CLL 23 chr20 ASXL1 31024274 T C 0.999 0.999 1 1 0.999CLL 23 chr7 PCLO 82451574 G T 0.001 0 0 0.014 0CLL 23 chr9 13995203 T C 0.999 0.999 0.998 0.998 0.999CLL 23 chr9 13995323 A G 0.999 0.999 0.999 1 1CLL 23 chrX BTK 100624888 T C 0 0.001 0.001 0.059 0.001CLL 23 chr1 NRAS 115256669 G A 1 1 1 1 1CLL 23 chr16 PLCG2 81891998 G C 1 1 1 1 1CLL 23 chr16 PLCG2 81892708 T A 1 1 1 1 1CLL 23 chr16 PLCG2 81892913 C T 0 0 0 0.081 0CLL 23 chr16 PLCG2 81973474 C A 1 1 1 1 1CLL 23 chr2 SF3B1 198265518 C A 0 0 0 0.01 0CLL 23 chr6 XPO5 43514357 AGGGG AGGGGG 0 0 0 0.018 0CLL 24 chrX BTK 100624820 T A 0.08 0.32 0.018 0.6 0.002CLL 24 chr9 NOTCH1 139413908 C T 0.761 0.57 0.532 0.513 0.512CLL 24 chr15 MGA 42041712 G A 0.316 0.47 0.527 0.55 0.468CLL 24 chr9 NOTCH1 139391636 G A 0.556 0.598 0.724 0.516 0.513CLL 24 chr11 NXF1 62567636 C T 0.529 0.516 0.676 0.559 0.484CLL 24 chr16 PLCG2 81887957 A C 0.524 0.555 0.386 0.462 0.489CLL 24 chr16 PLCG2 81887903 A G 0.512 0.544 0.376 0.449 0.471CLL 24 chr16 PLCG2 81887938 T C 0.523 0.553 0.385 0.461 0.486CLL 24 chrX DDX3X 41203410 T C 0.004 0.006 0.004 0.152 0.003CLL 24 chrX MED12 70339254 G A 0.219 0.205 0.352 0.125 0.223CLL 24 chr16 PLCG2 81819768 T C 0.379 0.5 0.466 0.457 0.51CLL 24 chr9 NOTCH1 139405093 G A 0.647 0.695 0.598 0.548 0.573CLL 24 chr1 NRAS 115256669 G A 0.467 0.397 0.457 0.731 0.514CLL 24 chr9 NOTCH1 139390397 C T 0.543 0.513 0.625 0.569 0.516CLL 24 chr9 NOTCH1 139404895 C T 0.599 0.641 0.538 0.333 0.529CLL 24 chr15 MGA 42026764 C T 0.404 0.506 0.512 0.524 0.452CLL 24 chr2 SF3B1 198265526 A G 0.394 0.417 0.501 0.5 0.489CLL 24 chr17 TP53 7573057 G A 0.56 0.457 0.479 0.457 0.489CLL 24 chr7 PCLO 82586054 G A 0.04 0.104 0.005 0 0.003CLL 24 chr9 NOTCH1 139404988 C T 0.598 0.642 0.554 0.407 0.543CLL 24 chr2 BIRC6 32696064 G C 0 0.002 0.001 0.095 0.001
Supplementary Table 3: CLL Cell Titrations
-
CLL 24 chr7 PCLO 82451558 T G 0.528 0.479 0.435 0.571 0.483CLL 24 chr16 PLCG2 81892708 T A 0.527 0.439 0.477 0.857 0.485CLL 24 chr7 PCLO 82451727 A G 0.068 0.088 0.012 0.151 0.006CLL 24 chr7 POT1 124511054 T C 0.092 0.073 0.021 0.069 0.099CLL 24 chr16 PLCG2 81819820 G A 0.516 0.473 0.549 0.667 0.527CLL 24 chr7 BRAF 140477781 A T 0.003 0.009 0.003 0.078 0.019CLL 24 chr16 PLCG2 81971403 T C 0.559 0.485 0.526 0.576 0.538CLL 24 chr15 MGA 41988432 T G 0.001 0.003 0.002 0.072 0CLL 24 chr7 PCLO 82451893 G A 0.008 0.015 0.018 0.071 0.003CLL 24 chr16 PLCG2 81892895 C T 0.341 0.406 0.374 0.25 0.362CLL 24 chr7 POT1 124492951 C A 0.002 0.002 0.001 0.063 0CLL 24 chr20 ASXL1 31024274 T C 0.524 0.462 0.515 0.486 0.492CLL 24 chr16 CREBBP 3807282 C T 0.556 0.558 0.501 0.6 0.5CLL 24 chr16 PLCG2 81914582 T C 0.001 0.003 0.002 0.055 0.004CLL 24 chr17 TP53 7579395 G A 0.003 0.002 0.001 0.052 0.001CLL 24 chr20 SAMHD1 35545122 T C 0.013 0.054 0.011 0.24 0.003CLL 24 chr2 SF3B1 198267001 C T 0.001 0.002 0.001 0.051 0.001CLL 24 chr2 BIRC6 32696062 T C 0.001 0 0 0.05 0.001CLL 24 chr6 HIST1H1E 26157076 A G 0.005 0.017 0.002 0.052 0.002CLL 24 chr9 37371644 C T 0.006 0.007 0.002 0.052 0.002CLL 24 chr6 RIPK1 3106076 C A 0.002 0 0.002 0.049 0CLL 24 chr3 KLHL6 183245823 A T 0.001 0.002 0.001 0.049 0.001CLL 24 chr16 PLCG2 81924883 A G 0.002 0.005 0.003 0.049 0.003CLL 24 chr3 MYD88 38182596 G A 0 0 0.047 0 0.001CLL 24 chr15 MGA 42003140 C T 0.043 0.048 0.009 0.179 0.003CLL 24 chrX FAM50A 153678659 A G 0.046 0.001 0.001 0 0.003CLL 24 chr15 MGA 41988427 A G 0.004 0.003 0.001 0.044 0.002CLL 24 chr16 CREBBP 3900706 G A 0 0 0.043 0 0CLL 24 chr1 FUBP1 78430019 A G 0.018 0.043 0.005 0.083 0.001CLL 24 chr20 SAMHD1 35544987 A G 0 0.044 0.007 0 0.002CLL 24 chr16 PLCG2 81888237 G C 0.519 0.508 0.504 0.478 0.491CLL 24 chr20 SAMHD1 35545494 C G 0 0.002 0 0.039 0CLL 24 chr6 RIPK1 3106153 G T 0.002 0.006 0.003 0.04 0.001CLL 24 chr16 PLCG2 81942108 G A 0.001 0 0 0.038 0CLL 24 chr16 CREBBP 3795158 C A 0 0.002 0.001 0.037 0.004
Supplementary Table 3: CLL Cell Titrations
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CLL 24 chr2 BIRC6 32713059 T A 0.954 0.961 0.951 0.97 0.988CLL 24 chr2 BIRC6 32713061 A T 0.952 0.958 0.949 0.969 0.986CLL 24 chr4 TET2 106196951 A G 0.452 0.478 0.479 0.404 0.489CLL 24 chr1 NRAS 115256550 T C 0.03 0.045 0.009 0 0.021CLL 24 chr1 NRAS 115256631 G A 0 0.04 0.004 0 0.006CLL 24 chr2 XPO1 61719303 C A 0 0.002 0.001 0.035 0.006CLL 24 chrX BTK 100614305 C T 0 0.034 0.001 0 0CLL 24 chr16 CREBBP 3777937 G T 0.033 0 0 0 0CLL 24 chr6 RIPK1 3106087 C A 0.004 0.003 0 0.033 0CLL 24 chrX FAM50A 153677325 C T 0 0 0 0.031 0.001CLL 24 chr16 PLCG2 81888152 A G 0.519 0.506 0.504 0.491 0.489CLL 24 chr2 XPO1 61719522 A G 0.031 0.017 0.006 0.125 0.001CLL 24 chr7 BRAF 140453204 G A 0 0 0.03 0 0CLL 24 chrX NLGN3 70388597 G A 0.038 0.057 0.054 0 0.027CLL 24 chr12 BAZ2A 56999649 T C 0.002 0.001 0 0.03 0.001CLL 24 chr16 PLCG2 81960659 C T 0 0 0.029 0 0.001CLL 24 chr16 PLCG2 81967975 C A 0 0 0.001 0.029 0.001CLL 24 chr6 RIPK1 3113346 C A 0.001 0.002 0.001 0.029 0CLL 24 chrX DDX3X 41203522 G A 0.001 0.029 0 0 0CLL 24 chr7 POT1 124532442 A G 0.001 0.003 0.003 0.029 0.002CLL 24 chr7 PCLO 82451597 A G 0.011 0.029 0.002 0 0.001CLL 24 chr1 NRAS 115256599 C T 0 0.032 0.005 0 0.005CLL 24 chr12 KRAS 25398220 A G 0.013 0.028 0.001 0 0.002CLL 24 chr2 SF3B1 198265619 T A 0 0.027 0.001 0.1 0.001CLL 24 chr2 SF3B1 198267212 T G 0.027 0.028 0.004 0.111 0.002CLL 24 chr6 HIST1H1E 26157171 C G 0.021 0.027 0.001 0.25 0.001CLL 24 chr3 MYD88 38182502 T G 0.004 0.008 0.004 0.026 0.001CLL 24 chr7 POT1 124532427 G A 0.001 0.001 0.001 0.026 0.001CLL 24 chrX BTK 100629537 T C 0.001 0.001 0.006 0.026 0.003CLL 24 chr2 XPO1 61719401 C T 0.018 0.004 0.001 0.8 0.025CLL 24 chr7 PCLO 82451681 A G 0.007 0.024 0.005 0.13 0CLL 24 chr17 TP53 7573920 C T 0 0 0.023 0 0CLL 24 chr7 POT1 124532331 C G 0 0.001 0 0.022 0CLL 24 chr7 PCLO 82451683 A G 0.007 0.023 0.004 0.125 0.001CLL 24 chr12 BAZ2A 56999761 T C 0.001 0.001 0 0.021 0.001
Supplementary Table 3: CLL Cell Titrations
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CLL 24 chrX BTK 100604757 T TG 0 0 0 0.021 0CLL 24 chr1 NRAS 115256523 T C 0.044 0.015 0.028 0.143 0.008CLL 24 chrX BTK 100604842 A G 0.002 0.005 0 0.02 0.002CLL 24 chr2 XPO1 61719471 T A 0.042 0.029 0.024 0.1 0.043CLL 24 chr1 NRAS 115256623 G A 0 0 0.005 0 0.018CLL 24 chr1 NRAS 115256609 TGG TG 0 0.024 0.01 0 0.007CLL 24 chr1 NRAS 115256636 G A 0 0.011 0.005 0 0.022CLL 24 chr16 PLCG2 81892694 T A 0.012 0.017 0.002 0.417 0CLL 24 chr2 BIRC6 32696068 T C 0.001 0.003 0.003 0.018 0.001CLL 24 chr2 XPO1 61719496 T G 0.004 0.021 0.004 0.1 0.007CLL 24 chr2 XPO1 61719503 T A 0.008 0.02 0.003 0.111 0.005CLL 24 chr20 SAMHD1 35539660 T C 0.012 0.018 0.002 0.448 0.001CLL 24 chr7 PCLO 82784531 G T 0.008 0.017 0 0 0CLL 24 chrX BTK 100613228 C T 0.001 0.002 0.001 0.018 0.003CLL 24 chrX NLGN3 70388664 G A 0.075 0.061 0.058 0 0.064CLL 24 chr11 NXF1 62569134 T A 0.011 0.017 0.003 0.07 0.001CLL 24 chr12 BAZ2A 57000163 A C 0.007 0.017 0.003 0.158 0.001CLL 24 chr16 PLCG2 81957109 C G 0.015 0.016 0.002 0.071 0CLL 24 chr17 TP53 7579258 G A 0.017 0.01 0.002 0 0.001CLL 24 chr2 SF3B1 198265518 C T 0.01 0.021 0.007 0.222 0.005CLL 24 chr2 BIRC6 32695918 T C 0.001 0.002 0.001 0.017 0.001CLL 24 chr16 PLCG2 81957111 C T 0.014 0.017 0.002 0.071 0CLL 24 chr2 XPO1 61719507 C A 0.012 0.019 0.004 0.2 0.006CLL 24 chr1 NRAS 115256585 T C 0 0.007 0.018 0.333 0.021CLL 24 chr1 NRAS 115256609 TGG TGGG 0 0 0 0 0.014CLL 24 chr16 PLCG2 81892961 C A 0 0.017 0.003 0 0.014CLL 24 chr16 PLCG2 81914574 T A 0.003 0.005 0.003 0.017 0.006CLL 24 chrX BTK 100604757 T G 0.995 0.997 0.998 0.985 0.999CLL 24 chr12 BAZ2A 56999839 T G 0 0 0.001 0.013 0.002CLL 24 chr16 PLCG2 81922736 T C 0.014 0.009 0.001 0.068 0.001CLL 24 chr16 PLCG2 81922931 G T 0.013 0.01 0 0 0CLL 24 chr9 37371652 C A 0.002 0.003 0.001 0.013 0CLL 24 chr16 PLCG2 81953081 T C 1 0.988 0.998 1 1CLL 24 chr16 PLCG2 81953081 T G 0 0.012 0.002 0 0CLL 24 chr16 PLCG2 81954789 C T 0.042 0.046 0.034 0.037 0.043
Supplementary Table 3: CLL Cell Titrations
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CLL 24 chr2 SF3B1 198267222 A C 0.006 0.012 0.001 0.088 0CLL 24 chr7 POT1 124511009 T C 0 0.014 0.002 0.065 0.002CLL 24 chr7 BRAF 140481377 A C 0.011 0.013 0.001 0 0.001CLL 24 chr20 SAMHD1 35545170 A C 0 0.011 0 0.074 0CLL 24 chr6 XPO5 43514357 A T 0 0.011 0.002 0.1 0CLL 24 chr9 37371644 C A 0.001 0.002 0.001 0.011 0CLL 24 chr16 PLCG2 81954789 C G 0.958 0.954 0.964 0.961 0.957CLL 24 chr20 SAMHD1 35545107 T C 0.052 0.011 0.007 0.083 0.001CLL 24 chr7 PCLO 82451574 G T 0.008 0.01 0 0 0.001CLL 24 chr16 PLCG2 81904375 C A 0.973 0.977 0.97 1 0.968CLL 24 chr16 PLCG2 81922757 G A 0.003 0.009 0 0.026 0.001CLL 24 chr7 PCLO 82451695 A G 0.01 0.008 0.001 0.147 0.002CLL 24 chr9 NOTCH1 139404962 T C 0.01 0.001 0.001 0 0.001CLL 24 chr17 TP53 7579472 G C 0.994 0.994 0.992 1 0.995CLL 24 chr17 TP53 7579801 G C 0.987 0.993 0.995 0.989 0.993CLL 24 chr1 NRAS 115256623 G C 0 0.006 0.014 0.045 0.006CLL 24 chr16 PLCG2 81904375 C T 0.027 0.022 0.03 0 0.03CLL 24 chr2 BIRC6 32688305 T A 0.005 0.01 0.002 0.188 0.002CLL 24 chrX BTK 100630143 A G 0.01 0.01 0.002 0 0.002CLL 24 chrX DDX3X 41204660 C T 0.003 0.007 0 0.067 0CLL 24 chrX DDX3X 41204663 G C 0.003 0.007 0 0.071 0CLL 24 chr1 NRAS 115256609 T C 0.025 0.006 0 0 0CLL 24 chr15 MGA 41961195 A G 0.001 0.007 0.002 0.041 0.001CLL 24 chr7 PCLO 82595759 T C 0.002 0.006 0.002 0.021 0CLL 24 chr11 NXF1 62569304 C G 0.002 0.005 0 0.077 0CLL 24 chr2 SF3B1 198266943 C T 0.999 1 0.998 0.995 0.999CLL 24 chr11 NXF1 62569279 T G 0.005 0.003 0.001 0.037 0.002CLL 24 chrX DDX3X 41203119 G A 0.999 0.998 0.997 0.995 0.997CLL 24 chr1 FUBP1 78425884 C T 0.001 0.003 0.001 0.022 0CLL 24 chr17 TP53 7577188 A T 0.003 0.004 0.003 0.034 0.001CLL 24 chr17 TP53 7577196 A G 0.003 0.005 0.002 0.032 0.002CLL 24 chrX NLGN3 70388722 A G 0.006 0.008 0.005 0.333 0.006CLL 24 chr12 CCND2 4383158 T C 0.995 0.997 0.996 0.997 0.996CLL 24 chr16 PLCG2 81902797 A G 0.999 0.999 1 0.999 0.998CLL 24 chr16 PLCG2 81929488 C T 1 0.999 1 0.998 0.998
Supplementary Table 3: CLL Cell Titrations
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CLL 24 chr16 PLCG2 81957303 T G 1 0.998 0.999 1 0.999CLL 24 chr20 ASXL1 31021424 G A 0 0.002 0.002 0.077 0CLL 24 chr20 ASXL1 31022959 T C 0.999 0.998 0.999 1 0.999CLL 24 chr7 PCLO 82595759 T G 0 0.001 0.002 0.011 0.002CLL 24 chr9 13995323 A G 1 0.998 0.999 0.999 0.998CLL 24 chrX FAM50A 153678706 C T 0.999 0.999 0.998 1 1CLL 24 chr16 PLCG2 81891998 G C 1 1 0.999 1 1CLL 24 chr16 PLCG2 81939150 G C 1 1 1 1 0.999CLL 24 chr16 PLCG2 81941319 C T 0.999 0.998 0.999 0.999 0.999CLL 24 chr16 PLCG2 81962071 A C 0.999 1 0.999 1 0.999CLL 24 chr16 PLCG2 81973474 C A 1 1 1 1 0.999CLL 24 chr17 TP53 7578115 T C 1 0.999 1 1 0.999CLL 24 chr2 BIRC6 32712875 A C 0.999 1 1 0.999 0.999CLL 24 chr7 BRAF 140481377 A G 0.022 0.001 0 0 0CLL 24 chrX BTK 100609547 G A 1 1 0.999 1 0.999CLL 24 chr11 NXF1 62569105 TA TACA 0 0 0 0.447 0CLL 24 chr12 BAZ2A 57000162 CAAAAA CAAAA 0 0 0 0.087 0CLL 24 chr15 MGA 42005504 TA T 0 0 0 0.103 0CLL 24 chr16 PLCG2 81934047 T C 1 1 1 1 1CLL 24 chr17 TP53 7578134 A T 0 0.001 0.001 0.048 0.001CLL 24 chr6 XPO5 43514357 AGGGG AGGG 0.025 0 0 0 0CLL 24 chr7 PCLO 82451574 GA GAA 0 0 0 0.083 0CLL 24 chr9 NOTCH1 139390521 GTTT GTT 0 0 0 0.018 0CLL 24 chr9 13995203 T C 0.999 0.999 0.999 0.999 0.999CLL 25 chr17 TP53 7578532 A T 0.764 0.812 0.541 0.667 0.839CLL 25 chrX BTK 100624820 T A 0.016 0.008 0.009 0.29 0.002CLL 25 chrX FAM50A 153678706 C T 0.081 0.118 0.1 0.33 0.09CLL 25 chr7 POT1 124465097 A T 0.53 0.373 0.341 0.403 0.407CLL 25 chr1 NRAS 115256669 G A 0.412 0.474 0.548 0.585 0.513CLL 25 chr7 PCLO 82451558 T G 0.413 0.502 0.378 0.461 0.539CLL 25 chr15 MGA 42026764 C T 0.538 0.391 0.489 0.517 0.495CLL 25 chr16 PLCG2 81892708 T A 0.448 0.481 0.553 0.406 0.525CLL 25 chrX BTK 100609547 G A 0.514 0.519 0.397 0.537 0.476CLL 25 chr16 PLCG2 81914583 C T 0.563 0.506 0.424 0.465 0.494CLL 25 chr16 PLCG2 81887938 T C 0.449 0.457 0.558 0.427 0.51
Supplementary Table 3: CLL Cell Titrations
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CLL 25 chr16 PLCG2 81887957 A C 0.451 0.457 0.558 0.428 0.511CLL 25 chr16 PLCG2 81887903 A G 0.44 0.445 0.546 0.418 0.496CLL 25 chr16 PLCG2 81819486 C G 0.463 0.461 0.447 0.57 0.494CLL 25 chr16 PLCG2 81957303 T G 0.467 0.503 0.453 0.573 0.486CLL 25 chr16 PLCG2 81888152 A G 0.587 0.516 0.476 0.476 0.493CLL 25 chr16 PLCG2 81888237 G C 0.587 0.514 0.477 0.477 0.492CLL 25 chr16 PLCG2 81902797 A G 0.452 0.528 0.551 0.441 0.516CLL 25 chr17 TP53 7579472 G C 0.111 0.037 0.146 0.117 0.14CLL 25 chr15 MGA 42041712 G A 0.525 0.421 0.477 0.507 0.481CLL 25 chr15 MGA 42041723 A G 0.474 0.576 0.519 0.498 0.516CLL 25 chr16 PLCG2 81892895 C T 0.408 0.367 0.31 0.401 0.306CLL 25 chr4 TET2 106196829 T G 0.488 0.564 0.5 0.525 0.469CLL 25 chr2 XPO1 61719472 C T 0.533 0.467 0.44 0.534 0.488CLL 25 chr4 TET2 106196951 A G 0.506 0.427 0.491 0.491 0.519CLL 25 chrX DDX3X 41203119 G A 0.507 0.465 0.434 0.489 0.525CLL 25 chr9 13995323 A G 0.521 0.449 0.527 0.536 0.498CLL 25 chr2 SF3B1 198267212 T G 0.001 0.001 0.002 0.085 0.001CLL 25 chr9 13995203 T C 0.524 0.454 0.533 0.536 0.486CLL 25 chr16 PLCG2 81954789 C G 0.41 0.445 0.364 0.414 0.371CLL 25 chr15 MGA 42003140 C T 0.002 0.003 0.005 0.082 0.002CLL 25 chr6 HIST1H1E 26157171 C G 0.001 0.001 0 0.08 0.001CLL 25 chr9 PAX5 37034095 C T 0.139 0.211 0.219 0 0.164CLL 25 chr16 PLCG2 81904375 C A 0.452 0.436 0.405 0.375 0.434CLL 25 chr2 XPO1 61719401 C T 0.002 0.01 0 0.077 0.022CLL 25 chr12 KRAS 25398220 A G 0.001 0 0.002 0.068 0.002CLL 25 chr7 PCLO 82451727 A G 0.004 0.003 0.007 0.069 0.002CLL 25 chrX NLGN3 70388664 G A 0.1 0.072 0.083 0.1 0.138CLL 25 chr17 TP53 7579801 G C 0.133 0.074 0.136 0.112 0.139CLL 25 chr6 XPO5 43514357 A T 0.001 0 0.003 0.058 0.001CLL 25 chr2 SF3B1 198265619 T A 0.001 0.001 0.001 0.052 0CLL 25 chr20 SAMHD1 35545122 T C 0.011 0.001 0.013 0.05 0.001CLL 25 chr6 XPO5 43535018 C T 0.477 0.512 0.517 0.524 0.505CLL 25 chr2 XPO1 61719507 C A 0.002 0.001 0.001 0.047 0.004CLL 25 chr17 TP53 7579258 G A 0.001 0 0 0.046 0.001CLL 25 chr1 FUBP1 78430019 A G 0.001 0.001 0.003 0.045 0.004
Supplementary Table 3: CLL Cell Titrations
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CLL 25 chr11 NXF1 62569134 T A 0.001 0.001 0 0.043 0CLL 25 chr2 SF3B1 198265518 C T 0.001 0.001 0.001 0.044 0.001CLL 25 chr20 SAMHD1 35544987 A G 0.003 0.002 0.003 0.045 0.002CLL 25 chr2 XPO1 61719503 T A 0.001 0.001 0 0.042 0.004CLL 25 chr20 SAMHD1 35539660 T C 0.001 0.004 0.002 0.043 0.001CLL 25 chrX BTK 100604757 T G 0.533 0.498 0.533 0.492 0.499CLL 25 chr16 PLCG2 81819768 T C 0.527 0.51 0.507 0.516 0.49CLL 25 chr16 PLCG2 81891998 G C 0.999 1 0.964 1 0.999CLL 25 chr1 NRAS 115256623 G A 0.006 0.051 0.019 0.041 0.008CLL 25 chr16 PLCG2 81892961 C A 0.004 0.032 0.003 0 0.037CLL 25 chrX BTK 100630143 A G 0.003 0.002 0.003 0.035 0.002CLL 25 chr16 PLCG2 81957109 C G 0.002 0.001 0.001 0.033 0CLL 25 chr16 PLCG2 81957111 C T 0.002 0.001 0.001 0.033 0CLL 25 chr2 SF3B1 198265526 A G 0.998 0.969 0.998 1 1CLL 25 chr2 BIRC6 32713059 T A 0.962 0.968 0.958 0.963 0.989CLL 25 chr9 37371644 C T 0.002 0.002 0.002 0.033 0.002CLL 25 chr1 NRAS 115256636 GAA GAAA 0.03 0.009 0.006 0 0.022CLL 25 chr2 BIRC6 32713061 A T 0.958 0.968 0.957 0.961 0.987CLL 25 chr7 BRAF 140453970 A G 0.001 0 0.001 0.03 0.002CLL 25 chr9 NOTCH1 139390539 G A 0.029 0 0 0 0.001CLL 25 chr1 NRAS 115256636 G A 0 0.028 0.006 0.027 0CLL 25 chr7 PCLO 82451695 A G 0.002 0.002 0 0.028 0.003CLL 25 chrX DDX3X 41204663 G C 0 0 0 0.027 0CLL 25 chr2 SF3B1 198267222 A C 0 0 0 0.026 0CLL 25 chr1 NRAS 115256523 T C 0.011 0 0 0.025 0CLL 25 chr7 PCLO 82451597 A G 0.002 0 0.002 0.025 0.002CLL 25 chrX DDX3X 41204660 C T 0 0.002 0.001 0.025 0.001CLL 25 chr16 PLCG2 81892694 T A 0 0 0.001 0.024 0.003CLL 25 chr2 XPO1 61719522 A G 0.001 0.001 0.003 0.025 0.004CLL 25 chrX NLGN3 70388597 G A 0.02 0.017 0.025 0 0.039CLL 25 chr2 BIRC6 32688305 T A 0.001 0 0.001 0.021 0.001CLL 25 chr6 HIST1H1E 26157076 A G 0.002 0.001 0.015 0.022 0.003CLL 25 chr20 SAMHD1 35545170 A C 0 0.001 0.003 0.02 0CLL 25 chr2 XPO1 61719496 T G 0.002 0.001 0 0.018 0.004CLL 25 chrX BTK 100626724 A G 0 0.003 0.001 0.018 0.002
Supplementary Table 3: CLL Cell Titrations
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CLL 25 chr7 PCLO 82451574 G A 0 0.001 0.017 0 0CLL 25 chr1 FUBP1 78425884 C T 0 0 0.001 0.016 0CLL 25 chr6 XPO5 43514357 AGGGG AGGGGG 0 0 0 0.016 0CLL 25 chr7 BRAF 140477781 A T 0.001 0.002 0.005 0.013 0.016CLL 25 chr16 PLCG2 81892895 C G 0.001 0 0 0.014 0CLL 25 chr16 PLCG2 81922736 T C 0.001 0.001 0.001 0.015 0.001CLL 25 chr2 BIRC6 32696064 G C 0.001 0.002 0.005 0.014 0CLL 25 chrX DDX3X 41203410 T C 0.005 0.007 0.005 0.019 0.007CLL 25 chrX NLGN3 70388722 A G 0.005 0.006 0.017 0 0.003CLL 25 chr11 NXF1 62569304 C G 0 0 0 0.013 0CLL 25 chr7 POT1 124511009 T C 0 0.001 0.001 0.013 0.002CLL 25 chr7 PCLO 82595759 T G 0.004 0.002 0.003 0.012 0CLL 25 chr16 PLCG2 81922931 G T 0 0 0 0.011 0CLL 25 chr7 PCLO 82451574 G T 0 0 0 0.011 0CLL 25 chr7 PCLO 82451681 A G 0.002 0.001 0.001 0.012 0.001CLL 25 chr7 PCLO 82451893 G A 0.004 0.003 0.009 0.012 0.001CLL 25 chrX NLGN3 70388737 A G 0.001 0.007 0.012 0 0.003CLL 25 chr17 TP53 7578146 T C 0.001 0.001 0.011 0 0CLL 25 chr20 SAMHD1 35545107 T C 0 0.005 0.003 0.011 0.001CLL 25 chr3 MYD88 38182502 T G 0.001 0.002 0.003 0.011 0.001CLL 25 chr7 POT1 124492951 C A 0.001 0.003 0.002 0.01 0CLL 25 chr7 PCLO 82595759 T C 0.002 0.002 0.003 0.012 0.002CLL 25 chr9 NOTCH1 139390397 C T 0.998 0.997 0.995 1 0.99CLL 25 chr1 NRAS 115256631 G A 0 0.009 0.005 0.013 0.014CLL 25 chr16 PLCG2 81954789 C T 0.02 0.025 0.022 0.027 0.029CLL 25 chr17 TP53 7577196 A G 0.002 0.001 0.001 0.01 0.002CLL 25 chr7 BRAF 140481382 A T 0.002 0.004 0.004 0.011 0CLL 25 chr7 PCLO 82451683 A G 0.001 0.001 0.001 0.01 0.001CLL 25 chr1 NRAS 115256623 G C 0 0.01 0.006 0.007 0.008CLL 25 chr1 NRAS 115256550 T TA 0 0.012 0.007 0 0CLL 25 chr16 PLCG2 81904375 C T 0.014 0.015 0.013 0.008 0.012CLL 25 chr17 TP53 7578115 T C 0.995 0.997 1 0.996 0.997CLL 25 chr12 CCND2 4383158 T C 0.996 0.993 0.994 0.996 0.997CLL 25 chr16 PLCG2 81953081 T C 0.995 0.998 0.996 0.994 0.994CLL 25 chr9 NOTCH1 139391636 G A 1 0.999 0.999 1 0.996
Supplementary Table 3: CLL Cell Titrations
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CLL 25 chr16 PLCG2 81962071 A C 0.997 1 1 0.999 0.999CLL 25 chr7 PCLO 82586054 G A 0.004 0.002 0.003 0.056 0.001CLL 25 chr16 PLCG2 81929488 C T 1 0.998 0.998 1 0.998CLL 25 chr16 PLCG2 81941319 C T 0.999 0.998 0.999 0.998 0.997CLL 25 chr20 ASXL1 31022959 T C 0.997 0.998 0.997 0.999 0.998CLL 25 chrX BTK 100624886 T C 0.004 0.002 0.002 0.019 0.002CLL 25 chr16 PLCG2 81934047 T C 0.999 1 0.999 1 1CLL 25 chr16 PLCG2 81939150 G C 1 1 1 1 0.999CLL 25 chr2 SF3B1 198266943 C T 0.998 0.998 0.998 0.998 0.999CLL 25 chr2 BIRC6 32712875 A C 0.999 0.998 0.999 0.999 0.999CLL 25 chr20 ASXL1 31024274 T C 0.999 0.999 0.999 0.998 0.999CLL 25 chr1 NRAS 115256636 GAA GA 0 0 0 0 0.011CLL 25 chr16 PLCG2 81973474 C A 1 1 1 1 1CLL 26 chr16 PLCG2 81902797 A G 0.853 0.477 0.33 0.574 0.496CLL 26 chr16 PLCG2 81914619 A C 0.124 0.515 0.547 0.428 0.462CLL 26 chr16 PLCG2 81917099 G T 0.202 0.522 0.62 0.48 0.505CLL 26 chr9 NOTCH1 139391636 G A 0.777 0.593 0.529 0.81 0.66CLL 26 chr2 SF3B1 198265526 A G 0.746 0.469 0.583 0.508 0.506CLL 26 chr7 POT1 124532340 G C 0.193 0.324 0.451 0.371 0.41CLL 26 chr16 PLCG2 81887938 T C 0.58 0.45 0.358 0.479 0.475CLL 26 chr16 PLCG2 81887957 A C 0.58 0.451 0.358 0.481 0.477CLL 26 chr16 PLCG2 81887903 A G 0.568 0.438 0.349 0.471 0.459CLL 26 chr16 PLCG2 81934047 T C 0.297 0.499 0.462 0.299 0.504CLL 26 chr2 BIRC6 32695880 G C 0.314 0.441 0.494 0.519 0.423CLL 26 chr16 PLCG2 81904375 C A 0.325 0.469 0.506 0.491 0.413CLL 26 chr16 PLCG2 81929488 C T 0.394 0.531 0.563 0.557 0.49CLL 26 chr7 POT1 124465097 A T 0.289 0.456 0.357 0.406 0.37CLL 26 chr17 TP53 7577427 G A 0.595 0.483 0.528 0.43 0.5CLL 26 chr16 PLCG2 81819486 C G 0.467 0.487 0.395 0.555 0.476CLL 26 chr16 PLCG2 81888237 G C 0.443 0.514 0.602 0.587 0.509CLL 26 chr17 TP53 7577407 A C 0.581 0.473 0.516 0.423 0.486CLL 26 chr16 PLCG2 81888152 A G 0.445 0.515 0.602 0.586 0.508CLL 26 chr16 PLCG2 81819768 T C 0.615 0.494 0.484 0.482 0.495CLL 26 chr2 SF3B1 198266611 C T 0.623 0.497 0.605 0.554 0.531CLL 26 chr9 13995203 T C 0.424 0.55 0.481 0.452 0.498
Supplementary Table 3: CLL Cell Titrations
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CLL 26 chr16 PLCG2 81990505 G T 0.117 0 0 0 0CLL 26 chrX BTK 100608191 G A 0.115 0 0 0 0.001CLL 26 chr17 TP53 7579801 G C 0.453 0.565 0.499 0.491 0.515CLL 26 chr20 SAMHD1 35539858 C G 0.434 0.505 0.425 0.468 0.53CLL 26 chr17 TP53 7579472 G C 0.461 0.556 0.48 0.472 0.488CLL 26 chr16 PLCG2 81892708 T A 0.529 0.46 0.444 0.436 0.475CLL 26 chr16 PLCG2 81892913 C T 0.093 0.002 0.001 0.001 0CLL 26 chr16 PLCG2 81892895 C T 0.295 0.386 0.374 0.374 0.351CLL 26 chr4 TET2 106197000 A G 0.088 0 0.001 0 0.001CLL 26 chr1 NRAS 115256669 G A 0.449 0.509 0.497 0.531 0.465CLL 26 chr12 BAZ2A 56996715 A G 0.074 0 0.001 0.001 0.001CLL 26 chr16 PLCG2 81971403 T C 0.563 0.543 0.544 0.497 0.507CLL 26 chr4 TET2 106196951 A G 0.486 0.449 0.468 0.452 0.514CLL 26 chrX BTK 100615669 G A 0 0 0.064 0.001 0.001CLL 26 chr15 MGA 42041712 G A 0.938 1 0.998 1 0.998CLL 26 chrX DDX3X 41203353 C A 0.059 0 0 0 0.001CLL 26 chr16 PLCG2 81819820 G A 0.054 0 0.001 0 0CLL 26 chr16 PLCG2 81971579 G A 0.054 0 0 0 0.001CLL 26 chr9 NOTCH1 139391794 G A 0.048 0 0 0 0CLL 26 chr9 13995264 G A 0.047 0 0 0.001 0.001CLL 26 chr1 NRAS 115256636 G T 0.046 0 0 0 0CLL 26 chrX BTK 100624820 T A 0.027 0.018 0.008 0.041 0.004CLL 26 chr6 HIST1H1E 26156758 C T 0 0.035 0.001 0.014 0.018CLL 26 chrX ZMYM3 70473062 A G 0.034 0 0.001 0 0.001CLL 26 chr12 BAZ2A 56993491 C T 0.033 0 0 0.001 0CLL 26 chr22 MAPK1 22127225 C T 0.033 0 0 0 0CLL 26 chr9 NOTCH1 139405072 C T 0.033 0 0 0 0CLL 26 chrX FAM50A 153678587 T C 0 0 0.034 0.001 0.001CLL 26 chr2 SF3B1 198266661 C T 0.032 0 0 0 0CLL 26 chrX DDX3X 41204782 T C 0.031 0.001 0 0 0CLL 26 chr1 FUBP1 78444378 A G 0.032 0.002 0 0 0.004CLL 26 chr7 PCLO 82595759 T G 0 0.03 0 0 0.001CLL 26 chr15 TGM7 43585863 T C 0 0 0.029 0.001 0.001CLL 26 chr3 MYD88 38180080 G A 0.029 0.001 0 0 0.001CLL 26 chr9 NOTCH1 139413252 T C 0.03 0.001 0 0 0.001
Supplementary Table 3: CLL Cell Titrations
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CLL 26 chrX BTK 100615688 T C 0.03 0.001 0.001 0.002 0.002CLL 26 chr1 NRAS 115256623 G A 0.006 0.015 0.007 0.006 0.034CLL 26 chr1 FUBP1 78430863 C T 0.028 0 0.001 0 0CLL 26 chr17 TP53 7576555 G A 0 0 0.028 0 0CLL 26 chrX BTK 100645521 A G 0.028 0 0.02 0 0CLL 26 chr1 NRAS 115256636 GAA GA 0.005 0.005 0.027 0 0CLL 26 chr16 PLCG2 81962330 T C 0.028 0.003 0.001 0.002 0.001CLL 26 chr1 NRAS 115256550 T C 0.022 0.005 0 0 0.026CLL 26 chr2 BIRC6 32713059 T A 0.965 0.962 0.957 0.967 0.983CLL 26 chr2 BIRC6 32713061 A T 0.963 0.96 0.956 0.966 0.981CLL 26 chr16 PLCG2 81929619 A G 0.025 0.001 0.001 0.001 0.003CLL 26 chr15 MGA 42003128 C T 0 0 0.023 0 0.001CLL 26 chr7 PCLO 82451893 G A 0.024 0.025 0.01 0.003 0.005CLL 26 chr7 BRAF 140477781 A T 0.012 0.015 0.006 0.008 0.027CLL 26 chr1 NRAS 115256585 T C 0.027 0.012 0.027 0.007 0.008CLL 26 chr1 NRAS 115256631 G A 0.015 0.004 0.024 0.006 0CLL 26 chr16 PLCG2 81954789 C T 0.053 0.038 0.035 0.033 0.05CLL 26 chr1 NRAS 115256636 GAA GAAA 0.015 0.019 0 0 0.01CLL 26 chr16 PLCG2 81954789 C G 0.947 0.962 0.963 0.966 0.95CLL 26 chr2 XPO1 61719401 C T 0.001 0.007 0.001 0.003 0.02CLL 26 chr1 NRAS 115256623 G C 0.017 0.005 0 0 0CLL 26 chrX DDX3X 41203410 T C 0.012 0.022 0.006 0.008 0.007CLL 26 chr7 PCLO 82586054 G A 0.006 0.011 0.003 0.016 0.003CLL 26 chr1 NRAS 115256550 T TA 0.011 0 0 0 0CLL 26 chr16 PLCG2 81914574 T A 0.013 0.012 0.007 0.002 0.004CLL 26 chr2 BIRC6 32696064 G C 0.004 0.011 0.001 0.006 0CLL 26 chr1 NRAS 115256550 TCC TC 0 0.01 0.008 0 0CLL 26 chr1 NRAS 115256636 G A 0.005 0.005 0 0.008 0.01CLL 26 chr2 BIRC6 32696062 T C 0.003 0.011 0.001 0.004 0.001CLL 26 chrX BTK 100624886 T C 0.011 0.001 0.001 0 0CLL 26 chr16 PLCG2 81914582 T C 0.005 0.006 0.001 0.01 0.003CLL 26 chr20 SAMHD1 35545122 T C 0.015 0.014 0.009 0.006 0.007CLL 26 chr7 PCLO 82784511 T C 0.01 0.015 0 0.006 0CLL 26 chr1 NRAS 115256523 T C 0.014 0.009 0 0.006 0.006CLL 26 chr16 CREBBP 3795158 C A 0.009 0.01 0.008 0.009 0.002
Supplementary Table 3: CLL Cell Titrations
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CLL 26 chr20 SAMHD1 35544987 A G 0.006 0.007 0.005 0.01 0.002CLL 26 chr7 POT1 124532442 A G 0.007 0.011 0.003 0.007 0.009CLL 26 chr16 PLCG2 81953081 T C 0.994 0.999 0.994 0.992 0.995CLL 26 chrX BTK 100604842 A G 0.01 0.007 0.005