Supplementary Figures for

Genesis of Two Most Prevalent PROP1 Gene Variants Causing Combined Pituitary

Hormone Deficiency in 21 Populations

Petra Dusatkova et al.

Supplementary Figure 1. Plots of observed haplotypes among patients with c.

[301_302delAG] in the PROP1 gene from all studied countries (A), from Europe except

Portugal and Spain (B), from Iberian Peninsula (C), from Argentina, Dominican Republic

and partly Brazil (D), from Jamaica, Panama and partly Brazil (E) and from healthy

European individuals derived from Hapmap (F).

The colours are displayed as follows: bright red represents LOD≥2 and D'=1, shade of red LOD≥2 and D'<1,

brightly pink LOD<2 and D'>0.5 and white LOD<2 and D'< 0.5. Numbers in each cell represents D' in percents. If

D'=1, no number is present in the respective cell.

A. Plots of observed haplotypes among patients with c.[301_302delAG] in the PROP1 gene from all studied countries.

A

B. Plots of observed haplotypes among patients with c.[301_302delAG] in the PROP1 gene from Europe except Portugal and Spain.

B

C. Plots of observed haplotypes among patients with c.[301_302delAG] in the PROP1 gene from Iberian Peninsula.

C

D. Plots of observed haplotypes among patients with c.[301_302delAG] in the PROP1 gene from Argentina, Dominican Republic and partly Brazil.

D

E. Plots of observed haplotypes among patients with c.[301_302delAG] in the PROP1 gene from Jamaica, Panama and partly Brazil.

E

F. Plots of observed haplotypes among patients with c.[301_302delAG] in the PROP1 gene from healthy European individuals derived from Hapmap.

F

Supplementary Figure 2. Plot of observed haplotype among patients with c.[150delA] in the PROP1 gene from all studied countries. The colours are displayed as follows: bright red represents LOD≥2 and D'=1, shade of red LOD≥2 and D'<1, brightly pink LOD<2 and D'>0.5 and white LOD<2 and D'< 0.5. Numbers in each cell represents D' in percents. If D'=1, no number is present in the respective cell.