supplementary material synthesis of pyrazolo[1,5-a
TRANSCRIPT
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Supplementary Material
Synthesis of pyrazolo[1,5-a]pyrimidine ring as a possible bioisosteric replacement of the 5-(1H-pyrrol-1-yl)pyrazole scaffold
Claudia Mugnaini, Livia Pasculini, Carlotta Pagli, Antonella Brizzi, Marco Paolino, Beatrice Gianibbi, and Federico Corelli*
Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy
Email: [email protected]
Table of Contents HPLC/MS traces for compounds 2a-f
Compound 2a ......................................................................................................................................................... S2
Compound 2b......................................................................................................................................................... S4
Compound 2c ......................................................................................................................................................... S6
Compound 2d......................................................................................................................................................... S8
Compound 2e ....................................................................................................................................................... S10
Compound 2f ....................................................................................................................................................... S12 13C NMR spectra of compounds 4,5 and 2a-f
Compound 4 ......................................................................................................................................................... S14
Compound 5 ......................................................................................................................................................... S15
Compound 2a ....................................................................................................................................................... S16
Compound 2b....................................................................................................................................................... S17
Compound 2c ....................................................................................................................................................... S18
Compound 2d....................................................................................................................................................... S19
Compound 2e ....................................................................................................................................................... S20
Compound 2f ....................................................................................................................................................... S21
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13C DEPT (CDCl3, 600 MHz) of compound 4.
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13C DEPT (CDCl3, 600 MHz) of compound 5.
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13C NMR (CDCl3, 400 MHz) of compound 2a.
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13C NMR (CDCl3, 400 MHz) of compound 2b
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13C NMR (DMSO-d6, 400 MHz) of compound 2c.
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13C NMR (DMSO-d6, 400 MHz) of compound 2d.
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13C NMR (DMSO-d6, 400 MHz) of compound 2e.
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13C NMR (CDCl3, 400 MHz) of compound 2f.