surface treatment of flexor tendon autografts with carbodiimide-derivatized hyaluronic acid by...
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![Page 1: Surface Treatment of Flexor Tendon Autografts with Carbodiimide-Derivatized Hyaluronic Acid by Chunfeng Zhao, Yu-Long Sun, Peter C. Amadio, Toshikazu Tanaka,](https://reader030.vdocument.in/reader030/viewer/2022032722/56649f465503460f94c68bf0/html5/thumbnails/1.jpg)
Surface Treatment of Flexor Tendon Autografts with Carbodiimide-Derivatized Hyaluronic Acid
by Chunfeng Zhao, Yu-Long Sun, Peter C. Amadio, Toshikazu Tanaka, Anke M. Ettema, and Kai-Nan An
J Bone Joint Surg AmVolume 88(10):2181-2191
October 1, 2006
©2006 by The Journal of Bone and Joint Surgery, Inc.
![Page 2: Surface Treatment of Flexor Tendon Autografts with Carbodiimide-Derivatized Hyaluronic Acid by Chunfeng Zhao, Yu-Long Sun, Peter C. Amadio, Toshikazu Tanaka,](https://reader030.vdocument.in/reader030/viewer/2022032722/56649f465503460f94c68bf0/html5/thumbnails/2.jpg)
Carboxyl groups in the hyaluronic acid (HA) are activated by EDC to form O-acylisoureas, which bind to the amino groups on the tendon surface.
Chunfeng Zhao et al. J Bone Joint Surg Am 2006;88:2181-2191
©2006 by The Journal of Bone and Joint Surgery, Inc.
![Page 3: Surface Treatment of Flexor Tendon Autografts with Carbodiimide-Derivatized Hyaluronic Acid by Chunfeng Zhao, Yu-Long Sun, Peter C. Amadio, Toshikazu Tanaka,](https://reader030.vdocument.in/reader030/viewer/2022032722/56649f465503460f94c68bf0/html5/thumbnails/3.jpg)
Illustration of the proximal suture technique.
Chunfeng Zhao et al. J Bone Joint Surg Am 2006;88:2181-2191
©2006 by The Journal of Bone and Joint Surgery, Inc.
![Page 4: Surface Treatment of Flexor Tendon Autografts with Carbodiimide-Derivatized Hyaluronic Acid by Chunfeng Zhao, Yu-Long Sun, Peter C. Amadio, Toshikazu Tanaka,](https://reader030.vdocument.in/reader030/viewer/2022032722/56649f465503460f94c68bf0/html5/thumbnails/4.jpg)
Work-of-flexion tester. 1 = actuator, 2 = load transducer, 3 = specimen, 4 = two metal beads in the middle phalanx, 5 = metal pin in the distal phalanx, 6 = metal pin in the proximal phalanx, 7 =
weight, and 8 = frame.
Chunfeng Zhao et al. J Bone Joint Surg Am 2006;88:2181-2191
©2006 by The Journal of Bone and Joint Surgery, Inc.
![Page 5: Surface Treatment of Flexor Tendon Autografts with Carbodiimide-Derivatized Hyaluronic Acid by Chunfeng Zhao, Yu-Long Sun, Peter C. Amadio, Toshikazu Tanaka,](https://reader030.vdocument.in/reader030/viewer/2022032722/56649f465503460f94c68bf0/html5/thumbnails/5.jpg)
Image obtained with fluoroscopy during testing.
Chunfeng Zhao et al. J Bone Joint Surg Am 2006;88:2181-2191
©2006 by The Journal of Bone and Joint Surgery, Inc.
![Page 6: Surface Treatment of Flexor Tendon Autografts with Carbodiimide-Derivatized Hyaluronic Acid by Chunfeng Zhao, Yu-Long Sun, Peter C. Amadio, Toshikazu Tanaka,](https://reader030.vdocument.in/reader030/viewer/2022032722/56649f465503460f94c68bf0/html5/thumbnails/6.jpg)
The work of flexion normalized according to the proximal and distal interphalangeal joint angle (normalized work of flexion) in the normal, cd-HA-treated, and saline-solution-treated groups at
one, three, and six weeks.
Chunfeng Zhao et al. J Bone Joint Surg Am 2006;88:2181-2191
©2006 by The Journal of Bone and Joint Surgery, Inc.
![Page 7: Surface Treatment of Flexor Tendon Autografts with Carbodiimide-Derivatized Hyaluronic Acid by Chunfeng Zhao, Yu-Long Sun, Peter C. Amadio, Toshikazu Tanaka,](https://reader030.vdocument.in/reader030/viewer/2022032722/56649f465503460f94c68bf0/html5/thumbnails/7.jpg)
The gliding resistance in the normal, cd-HA-treated, and saline-solution-treated groups at one, three, and six weeks.
Chunfeng Zhao et al. J Bone Joint Surg Am 2006;88:2181-2191
©2006 by The Journal of Bone and Joint Surgery, Inc.
![Page 8: Surface Treatment of Flexor Tendon Autografts with Carbodiimide-Derivatized Hyaluronic Acid by Chunfeng Zhao, Yu-Long Sun, Peter C. Amadio, Toshikazu Tanaka,](https://reader030.vdocument.in/reader030/viewer/2022032722/56649f465503460f94c68bf0/html5/thumbnails/8.jpg)
The staining intensity of the cd-HA and saline-solution-treated tendon grafts at one, three, and six weeks.
Chunfeng Zhao et al. J Bone Joint Surg Am 2006;88:2181-2191
©2006 by The Journal of Bone and Joint Surgery, Inc.
![Page 9: Surface Treatment of Flexor Tendon Autografts with Carbodiimide-Derivatized Hyaluronic Acid by Chunfeng Zhao, Yu-Long Sun, Peter C. Amadio, Toshikazu Tanaka,](https://reader030.vdocument.in/reader030/viewer/2022032722/56649f465503460f94c68bf0/html5/thumbnails/9.jpg)
A: cd-HA-treated tendon graft harvested at six weeks, showing a smooth surface without adhesions to the flexor sheath.
Chunfeng Zhao et al. J Bone Joint Surg Am 2006;88:2181-2191
©2006 by The Journal of Bone and Joint Surgery, Inc.
![Page 10: Surface Treatment of Flexor Tendon Autografts with Carbodiimide-Derivatized Hyaluronic Acid by Chunfeng Zhao, Yu-Long Sun, Peter C. Amadio, Toshikazu Tanaka,](https://reader030.vdocument.in/reader030/viewer/2022032722/56649f465503460f94c68bf0/html5/thumbnails/10.jpg)
A: cd-HA-treated tendon graft harvested at six weeks, showing a smooth surface under scanning electron microscopy (×30).
Chunfeng Zhao et al. J Bone Joint Surg Am 2006;88:2181-2191
©2006 by The Journal of Bone and Joint Surgery, Inc.