surveillance of blood utilisation usefulness for hemovigilance€¦ · robert curthose , 1080 son...
TRANSCRIPT
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Surveillance of blood utilisation
Usefulness for hemovigilance
Jonathan Wallis
Freeman Hospital
Newcastle upon Tyne UK
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Northumbria
A Land of hills.....
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..... and castles
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Chillingham Castle
We could not calculate the risks of transmitting vCJD
if we did not know who was receiving blood transfusion
and, what happened to them
1995
Human case of
Mad cow disease or vCJD
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Haemovigilance
Recording and collating
adverse effects of transfusion
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Haemovigilance
Recording and collating adverse effects of
transfusion with the aim of improving the
benefit to risk ratio
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Would you transfuse a unit of possibly
vCJD infected blood to this patient?
21 year old mother ex-sanguinating from PPH
77 year old THR with CVD, post op Hb 5.6g/dL
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21 year old mother
• Likely to prevent death
• 60 yrs life saved
• Significant societal gain
But..
• Infection devastating
77 year old THR
• Death less likely
• 7 yrs life saved
• Better rehabilitation
But..
• Infection may not to be
clinically manifest
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Haemovigilance
Does not operate in a moral or economic vacuum
The risk benefit equation depends on many factors
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The ‘New Castle on Tyne’ built by
Robert Curthose , 1080
Son of William the Conqueror
William commissioned the Doomsday book
This detailed every farmstead, every peasant,
every house in England.
'there was no single hide nor a yard of land,
nor indeed one ox nor one cow nor one pig
which was left out.'
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Recipient factors
Who is transfused
Age
Sex
Why are they transfused
Underlying disease
Immediate indication
How long will they
survive
Procedural factors
Where are they transfused
Theatres
Day units
Home
When are they transfused
Day
Night
How old is the blood
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Recipient factors
Who is transfused
Age
Sex
Why are they transfused
Underlying disease
Immediate indication
How long will they
survive
Procedural factors
Where are they transfused
Theatres
Day units
Home
When are they transfused
Day
Night
How old is the blood
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Where does Blood Go? Wells, A.W et al. 2002. BMJ, 325, 803-7
Simple paper based survey
Done in real time
Filled in by hospital blood bank
Data collected for 2 weeks x 2
All hospitals in the Northern region
Population 2.9 million
All supplied by Newcastle BTS
99% complete returns
Findings reported to each blood bank
Costs = £0.00
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Transfusion by age
0-4
5-9
10-1
4
15-1
9
20-2
4
25-2
9
30-3
4
35-3
9
40-4
4
45-4
9
50-5
4
55-5
9
60-6
4
65-6
9
70-7
4
75-7
9
80-8
485
+0
500
1000
1500
FemaleMale
Age
Un
its t
ran
sfu
sed
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Use by speciality
No details0%
Medicine52%
O & G7%
Surgery41%
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Surgical category Total Percentage of
surgical use
Percentage of
total use
Cardiac
(Excluding heart/lung
transplant)
336 14.2 4.1
ENT 37 1.6 0.5
Abdominal surgery
(excluding solid organ
transplant)
398 16.9 4.9
Neurosurgery 31 1.3 0.3
Trauma (including
fractured femur)
280 11.8 3.4
Urology 112 4.7 1.4
Solid organ transplant 67 2.8 0.84
Orthopaedic 608 25.8 7.5
Vascular 202 8.6 2.5
Plastic surgery 56 2.4 0.8
Other surgery 233 9.9 2.9
Total 2360 100 29
Table 2: Surgical indications for red cell use 2009.
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Recipient factors
Who is transfused
Age
Sex
Why are they transfused
Underlying disease
Immediate indication
How long will they
survive
Procedural factors
Where are they transfused
Theatres
Day units
Home
When are they transfused
Day
Night
How old is the blood
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How long do red cell recipients survive?
0 12 24 36 48 600
25
50
75
100
Expected
All patients
Survival (months)
%
Wallis et al Transfusion 2004
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Patient survival by number of red cells
received
0 12 24 36 48 600
25
50
75
1001-2 units
3-4 units
5-6 units
7-8 units
9-10 units
>10 units
Survival
%
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Survival by red cell units
0 12 24 36 48 600
25
50
75
100
Expected(5 yr survival 83.0%)
Survival by red cell units(Median survival 30 months, 5 yr survival 40.9%)
Survival (months)
%
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Recipient factors
Who is transfused
Age
Sex
Why are they transfused
Underlying disease
Immediate indication
How long will they
survive
Procedural factors
Where are they transfused
Theatres
Day units
Home
When are they transfused
Day
Night
How old is the blood
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More transfusions happen on a
Wednesday!
0
100
200
300
400
500
600
Mon Tues Wed Thurs Fri Sat Sun NK
Courtesy of Dr Hazel Tinegate
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Transfusion Location
Hazel Tinegate et al NHSBT & SHOT
13%
13%
13%
2%
57%
2%
Th/recov
ITU/HDU/SCBU
OP/DU
AE
Ward
Other
11%
7%
4%
4%
72%
2%
Northern and Yorkshire data SHOT data 2005
Adverse events are more likely to be reported for
1.transfusions given on A/E, and general wards
2.Transfusions given out of normal working hours
3. Transfusions cross matched out of hours
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Utilisation surveys help inform
Haemovigilance
Provide demominator data
Predicting future risks
Identifying high risk areas
Cost benefit calculations for interventions
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March 2012
Blood service:
‘A donor has converted to HIV positive, the last
unit pre-conversion came to your hospital’
Me:
‘ Whoops, OK I’ll find out who received the blood’
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Questions
Is the recipient still alive?
Has the recipient developed HIV?
Was the transfusion justified?
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Exposing a patient to a measured risk....
OK
Exposing a patient to an unnecessary risk...
Not OK
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Haemovigilance
Recording and collating adverse effects of
transfusion with the aim of improving the
benefit to risk ratio
Knowing all transfusion carries some risk ,
ensuring that transfusion is always justified
on clinical grounds
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There are things we know
There are known unknowns
And there are unknown unknowns
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Country Red cell use per
1000 population
Ratio FFP:RC
France 32.8 1:7.7
Netherlands 36.6 1:6.7
UK 41.4 1:7.1
Sweden 50.5 1:4
Germany 54.4 1:3.3
Greece 59.3 1:2.6
Denmark 72.9 1:6
Report on the collection, testing and use of blood and
blood components in Europe in 2004
CL Van der Poel et al. Council of Europe
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Country Red cell use per
1000 population
Ratio FFP:RC
France 32.8 1:7.7
Netherlands 36.6 1:6.7
UK 41.4 1:7.1
Sweden 50.5 1:4
Germany 54.4 1:3.3
Greece 59.3 1:2.6
Denmark 72.9 1:6
Canada 2008* 35.2 ???
USA 2008** 48.8 1:3.6 (2001)
UK 2009 36 1:7
Report on the collection, testing and use of blood and
blood components in Europe in 2004
CL Van der Poel et al. Council of Europe
Drackley et al Transfusion 2012; 52:366-74
**www.census.gov/ipc/www/idb/country.php
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1999/2000 2004 2009
Units
transfused
Percentage
of all blood
transfused
Units
transfused
Percentage
of all blood
transfused
Units
transfused
Percentage
of all blood
transfused
Medical 5047 52 5558 62 5156 64.2
Surgical 3982 41 3001 33 2360 29.4
Obs/Gyn 612 6 444 5 509 6.4
Total units
transfused
9774 9003 8025
Changes in blood use in North of England 1999-2009
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0
100
200
300
400
500
600
700
10
-14
15
-19
20
-24
25
-29
30
-34
35
-39
40
-44
45
-49
50
-54
55
-59
60
-64
65
-69
70
-74
75
-79
80
-84
85
-89
90
+
Tota
l
Un
its r
ed
cells u
sed
ov
er
28 d
ays
Surgical use of red cells over 10 years
Surg 2009
Surg 2004
Surg 1999
0
100
200
300
400
500
600
700
800
900
Un
its r
ed
cells u
sed
ov
er
28 d
ays
Medical use of red cells over 10
years
Med 2009
Med 2004
Med 1999
0
20
40
60
80
100
120
140
0
5-9
15
-19
25
-29
35
-39
45
-49
55
-59
65
-69
75
-79
85
-89
Un
its r
ed
cells u
sed
ov
er
28 d
ays
Obstetric and Gynaecology use of red cells over 10 years
O&G 2009
O&G 2004
O&G 1999
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0
500
1000
1500
2000
2500
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
Issues, 1000s
Red cell issues in England and N Wales 1992-2009
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What led to the change?
Transfusion in Critical Care Trial
Hebert et al NEJM 1999
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Causes of change in red cell use
• TRICC trial: Changes in transfusion triggers
• Introduction of transfusion practitioners
• ‘Better Blood Transfusion’ initiative
• Increasing cost of blood
• (Reduction in cardiac surgery)
• (Improvement in surgical techniques)
• (Cell salvage)
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Country Red cell use per
1000 population
Ratio FFP:RC
France 32.8 1:7.7
Netherlands 36.6 1:6.7
UK 41.4 1:7.1
Sweden 50.5 1:4
Germany 54.4 1:3.3
Greece 59.3 1:2.6
Denmark 72.9 1:6
Canada 2008* 35.2 ???
USA 2008** 48.8 1:3.6 (2001)
UK 2009 36 1:7
Report on the collection, testing and use of blood and
blood components in Europe in 2004
CL Van der Poel et al. Council of Europe
Drackley et al Transfusion 2012; 52:366-74
**www.census.gov/ipc/www/idb/country.php
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Red cell use in cardiac surgery
US: 7.1% of 48.8 = 3.5 units per 1000 pop
UK: 4.1% of 35 = 1.5 units per 1000 pop
United States Census Bureau. International Database.
[cited 2010 Dec 30]. Available from: URL: http://
www.census.gov/ipc/www/idb/country.php
Tinegate et al. Submitted for publication 2012.
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0
200
400
600
800
1000
1200
0 1 to
4
5 to
9
10 to
14
15 to
19
20 to
24
25 to
29
30 to
34
35 to
39
40 to
44
45 to
49
50 to
54
55 to
59
60 to
64
65 to
69
70 to
74
75 to
79
80 to
84
85 to
89
90 +
Age
To
tal
un
its
O & G Surgery Medicine
Red cell use by age
North of England 2009
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0
50
100
150
200
250
0-4 5-9 10-
14
15-
19
20-
24
25-
29
30-
34
35-
39
40-
44
45-
49
50-
54
55-
59
60-
64
65-
69
70-
74
75-
79
80-
84
85+
age
un
its
per
an
nu
m
Units red cells per annum per thousand
population
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One year period prevalence of blood transfusion
Madsen, Titlestad et al, Transfusion medicine 2010; 20: 191-5
• Standardised transfusion rates based on
WHO standard population structure
• Allows comparison between populations
without population demographics affecting
results.
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If one country is using > 2x as much blood
for cardiac surgery than another..
If transfusion of stored blood has deleterious
effects..... (See Koch et al NEJM 2009, Murphy et al )
Then these differences should be far more
important to haemovigilance officers than
rates of minor allergic reactions
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Utilisation studies
Who is transfused
Age
Sex
Why are they transfused
Underlying disease
Immediate indication
How long will they
survive
Where are they transfused
Theatres
Day units
Home
When are they transfused
Day
Night
How old is the blood
Recipient factors Procedural factors
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Proposed ISBT Indication codes for erythrocyte transfusion
• E1 Acute blood loss ie active bleeding – To maintain Hb >70g/L in an otherwise fit patient
– To maintain Hb >80g/L in an elderly but otherwise fit patient
– To maintain Hb >90g/L in a patient with known cardiovascular disease
• E2 Acute anaemia eg post operative but haemodynamically stable – To maintain Hb >70g/L in an otherwise fit patient
– To maintain Hb >80g/L in an elderly but otherwise fit patient
– To maintain Hb >90g/L in a patient with known cardiovascular disease
• E3 Chronic correctable anaemia – Planned surgical procedure and Hb 70-100g/L depending on procedure
– To reduce symptoms/ enable discharge from hospital????
– Frequent Angina or heart failure
• E4 Chronic anaemia that is not correctable – Bone marrow failure inherited. To maintain Hb > xx
– Bone marrow failure acquired. To alleviate symptoms, typically to maintain Hb> 80g/L
– Continuous bleeding or haemolysis
• E5 To alleviate damage due to patient’s own red cells – Acute top up or exchange transfusion for sickle cell crisis
– Chronic exchange transfusion for sickle cell disease
– Exchange transfusion to prevent kernicterus
– Exchange transfusion for malaria
– Other
• E6. Radiotherapy – To maintain Hb >110g/L for radiotherapy where this has been shown to be associated with a better response
to treatment.
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Clinical code
• Surgical
– Orthopaedic
• TRH 18
• TKR 19
• Spinal 20
• Other 21
– Cardiac
• CABG 1st 22
• CABG redo 23
• Valve 24
• Other 25
• Medical
– GI bleeding 41
– Haematology 42
– ....
– ....
– .....
Indication code
• E1 active bleeding
– Trigger <7g/dl young
– Trigger <8g/dl elderly
– Trigger <9g/dl Acute coronary
• E2 Acute anaemia but
haemodynamically stable
– <7g/dl
– <8g/dl
– <9g/dl
• E3 Chronic correctable anaemia
• E4 Anaemia not correctable
– .......
– ........
– .......
CODE = 20 E2
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How?
• Paper or electronic
• Intermittent or continuous
• Prospective or Retrospective
• Simple codes or CD codes (eg AIM2 )
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Surveillance of blood utilisation
Usefulness for hemovigilance?
Utilisation surveillance should be
an integral part of haemovigilance
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and another thing.....
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ABO errors SHOT 2010
There was 1 case of major morbidity reported as a result of an ABO incompatible transfusion
. A patient with a haematemesis was in need of an urgent blood
transfusion.
The patient’s wristband was contaminated with blood and could not be read
As a consequence the electronic bedside checking system was not used.
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ABO errors SHOT 2009
• An elderly patient with an underlying heart condition was transfused, during hip arthroplasty….
• An elderly patient was admitted as an emergency during the night
with chest pain, ECG changes, chest infection and iron deficiency anaemia, and was deteriorating….
• ITU patient receives ABO-incompatible transfusion despite electronic bedside device…
• Cancer day unit: Incorrect unit collected and transfused despite training, competency-assessment and fridge locking system…
• Man receives emergency transfusion which is both ABO and D incompatible with no ill effects…
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Group O blood only for non-elective
transfusion
• Sampling errors..mainly out of hours
• Administration errors..mainly out of hours
• Collect more group o red cells with apheresis
• Use fresh gp O blood for all non elective transfusions
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Alnwick Castle, Northumbria
53 Getting blood transfusion right is not always a picnic