1. SURVIVING CANCERWE ARE IMPROVING BY LEAPS ANDBOUNDS!Published by Medical Business Systems creators ofIridium Suite Practice Management System www.iridiumsuite.com

2. 5 YEAR CANCER SURVIVOR RATESNow2 out of 3In 1970s1 out of 2The nations cancer death rate has dropped 18%since the 1990s! 3. SIGNIFICANT ADVANCES HAVE BEEN MADE IN:ChemotherapyPreventive MeasuresRadiation TherapyScreening and Early DiagnosisSurgical InterventionTargeted Molecular Therapy 4. ASCO RECENTLY PUBLISHEDA CANCER MILESTONES TIMELINEL E T S L O O K AT S O M E O F T H E H I G H L I G H T SSources: http://www.cancerprogress.net, Major Milestones AgainstCancerhttp://seer.cancer.gov/statfacts/html/colorect.html 5. Breast cancer was a diagnosisthat almost always proved fataldue to recurrent disease. Thisprocedure had immediateimpact. Today, breast cancersurgeries have become muchmore conservative. Mostwomen are able to avoidmastectomy.IN THE1880Sthe RadicalMastectomywas pioneeredby surgeonWilliam Halsted89.2 %survive 5years12.3 % of women will be diagnosed with breast cancer at somepoint during their lifetime, based on 2009-11 Natl Cancer Institutedata. 6. Early radiation wasadministered asBrachytherapy, atechnique that survivestoday. More advancedtherapies like IMRT, SBRT,and Proton therapyincrease the ability totarget cancer cells andspare normal surroundingtissues.IN 1903Radiationtherapy withRadium wasfirst used inRussia to treatskin cancer.A patient may receive radiationtherapy alone, before, during, or aftersurgery, or in combination withchemotherapy. 7. Since the 1950s,widespread use of the Paptest has helped to reduceU.S. cervical cancer deathrates by nearly 70 %.Cervical cancer is almostalways caused by humanpapillomavirus (HPV)infection.IN 1943GeorgePapanicolaouinvented thePap Test forthe detection ofcervical canceror pre-cancers.67.9%survive 5years.7 % of women will bediagnosed with cervical cancerat some point during theirlifetime, based on 2009-11Natl Cancer Institute data. 8. This is also know asmustard gas that hadbeen used as aweapon in World WarII. It was approved forthe treatment ofHodgkin lymphoma.IN 1949The firstchemotherapydrug NitrogenMustard wasapproved bythe FDA.Nitrogen Mustard is stillsometimes used today incombination with other drugs totreat Hodgkin lymphoma.85.3%survive 5years 9. IN THE1950S-1960SSStudies showthat smoking isa major causeof cancer,particularlylung cancer.6.8 % will be diagnosed with lung cancer atsome point during their lifetime, based on2009-11 Natl Cancer Institute data.16.8%survive 5yearsIn the early 1960s, theU.S. Surgeon Generalissued a report linkingsmoking to cancer. Laterreports declare second-handsmoke a threat tothe health of non-smokers.Smoking is themost common cause oflung cancer. 10. In 1970, the regimenABVD cured 70% withadvanced Hodgkinlymphoma and remains amainstay of treatmenttoday.IN 1965Chemotherapyregimen MOPPcured 50% ofpatients withadvancedHodgkinlymphoma.85.3%survive 5years.2 % will be diagnosed withHodgkin lymphoma at somepoint during their lifetime, 11. IN 1967The guaiacfecal occultblood test(FOBT) isintroduced as ascreening testfor colorectalcancer64.7%survive 5yearsIn the next few years, theuse of two new screeningtechniques flexiblesigmoidoscopy andcolonoscopy combinedwith FOBT drasticallyreduced colorectal cancermortality a total declineof more than 40 percentsince 1975.4.7 % will be diagnosed withlung and bronchus cancer atsome point during their lifetime, 12. Brachytherapydates back to the1900s, but forprostate cancer"seeds" areimplanted directlyinto the prostategland. The highdose of radiationis delivereddirectly to thetumor sparingmost of thehealthy.IN THE1970SBrachytherapybecomes thepreferredtreatment forprostate cancerover surgery.98.9%survive 5years 13. This becomes oneof the standards ofcare for eaarlystage breastcancer and pavesthe way for thesame type oftreatmentregimens forcolon, lung andother cancers.IN1975-1976Adjuvantchemotherapy prolongs thelives of womenwith earlystage breastcancer.About 90% of women with early-stagebreast cancer are alive five years aftertheir diagnosis. 14. A pivotal trialdemonstrated thatthe cocktail of thedrugs cisplatin,vinblastine andbleomycin cured70% of patientswith advancedtesticular cancer.IN 1977Newtreatmentscuretesticularcancer.Today, the overall cure rate for testicularcancer (all stages) is a remarkable 95%. 15. This increase allowsfor earlier detectionand moresuccessfultreatment.By mid-1980s 33%of women over 40and by 2008 70%are screenedregularly.LATE 1970SThe use ofmammographyfor breastcancerscreeningbecomes morecommon.Since 1975, breast cancer mortality hasbeen reduced by 27%. 16. PSA testing doesallow for earlydetection, but itsuse has sparkedcontroversy:Improved survivalratesvs.Unnecessarytreatment of slow-growingcancersthat would neverhave become life-threatening.IN 1986The PSA testwas approvedby the FDA forearly detectionof prostatecancer.Prostate cancer is themost common cancerin men over 50. 17. These new drugsassist in treatinganemia fromchemotherapy.This reduces theneed for bloodtransfusions.Additional whiteblood cellboosting drugsreduce infectionandhospitalizationrates.IN 1989Drugs areapproved tostimulateproduction ofred blood cells. 18. This newtechnology meansthat radiation canbe targeted attumors frommultiple angles,with beams ofvarying power.This results inminimizingdamage to healthysurroundingtissue.EARLY 1990SRadiationtherapy beginsto utilizecomplex 3Dcomputerplanningsystems. 19. 2.6 %between1991 and 199518%between1991 and 2008EARLY 1990SSincemeasurementbegan in the1930s, cancermortality ratesstart a steadydecline.American Cancer Society projects for 2010 there were 569,490 cancerdeaths overall, including 157,300 deaths from lung cancer; 51,370 fromcancers of the colon/rectum; 39,840 from female breast cancer; 36,800deaths from cancer of the pancreas; and 32,050 from prostate cancer. 20. Melanoma is themost aggressive formof skin cancer.Studies published1970-1990sestablished excessivesun exposure andsunburns to be riskfactors in developingmelanoma.IN 1992Sentinel lymphnode biopsy isused to stagecancers,especiallymelanoma.91.3%survive 5years2.1 % will be diagnosed with melanoma atsome point during their lifetime based on2009-11 Natl Cancer Institute data. 21. These cancers areespecially affected byobesity: endometrial,breast, prostate andcolon.In 2003, studiesshow that obesittycould account for upto 20% of U.S. cancerdeaths.IN 1998Studies linkobesity to anincreased riskof commoncancers.34.9% ofU.S.adults areobese.The National Institute of Health issues guidelinesfor treating obesity in adults.Get your Obesity Education Initiative guide:http://www.nhlbi.nih.gov/files/docs/guidelines/ob_gdlns.pdf 22. In 2006, trastuzumabwas approved as partof the adjuvanttreatment regimen foreaarly-stage HER2-positive breastcancer. This reducedrecurrence rates by50%.IN 1998The FDAapproved thedrugtrastuzumab totreat advancedbreast cancer.25% of breastcancer patientshave HER2-positive diseaseRecently, trastuzumab was alsoFDA-approved to treat patientswith stomach cancers that havea similar over-production of theHER2 protein. 23. In 2005, The CancerGenome Atlasproject, began itsinitial phase todevelop acomprehensive atlasof the genomes ofthree commoncancers lung,ovarian, andglioblastoma.IN 2003A group ofinternationalscientists weresuccessful atmapping the 3billion DNA lettersin the humangenome.Get a copy of The Cancer Genome Atlashttp://www.genome.gov/Pages/Research/DER/TCGA/TCGABrochure.pdf 24. That vaccine,Gardasil is laterapproved to preventadditional HPV-relateddiseasesincluding vaginal,vulvar and analcancers in females,and anal cancer inmales.IN 2006FDA approves thefirst vaccine toprevent infectionwith two high-riskstrains of thehumanpapillomavirus(HPV16 & HPV18)Studies have also linked HPVinfection to head and neckcancers.70% of cervicalcancer is causedby HPV16 &18infections. 25. The indication forLDCT screening usein the generalpopulation is stillbeing evaluated.IN 2010Study resultspublished on theeffect of annualscreening withlow-dose spiral CTscans for currentand previousheavy smokers.Advanced lung cancerpatients treated withchemotherapy andpalliative careimmediately after theirdiagnosis lived threemonths longer and had ahigher quality of life thanpatients who hadchemotherapy alone.20% reduction inlung cancermortality shown. 26. 13.7 millionsurvivors in2012comparedto 3 millionin 1971.IN 2012A recordnumber ofcancersurvivors arereported by theNationalCancerInstitute andthe AmericanCancer Society.The prediction for 2022 is 18 million survivors.