susan s. wallace

Susan S. Wallace Curriculum vitae

EDUCATION

Marymount College, Tarrytown, NY B.S. 1959 Chemistry & Mathematics

University of California, Berkeley 1959-1961

Advanced to Candidacy for the Ph.D. in Biophysics 1960

M.S. 1961 Bioradiology

Cornell University, Graduate School of Medical

Sciences, Sloan Kettering Division Ph.D. 1965 Biophysics

Columbia University College of Physicians & Surgeons Post-Doctoral 1965-1967 Immunochemistry

ACADEMIC APPOINTMENTS

Professor & Chair, Department of Microbiology and Molecular Genetics, University of Vermont 1988-present

Graduate Faculty, University of Vermont 1988-present

Member, Vermont Cancer Center 1988-present

Director, Vermont Cancer Center Genome Stability and Expression Program 1993-2010

Director, Cancer Biology Graduate Training Program 2004-2009

Director, Department of Energy Vermont EPSCoR Program 2000-2007

Professor, Department of Microbiology, New York Medical College 1979-1988

Associate Professor, Department of Microbiology, New York Medical College 1976-1979

Graduate Program Director, Department of Microbiology, New York Medical College 1977-1987

Sabbatical Leave, Albert Einstein College of Medicine, Laboratory of Dr. Jerard Hurwitz 1974-1975

Associate Professor of Biological Sciences, Herbert H. Lehman College, City University of NY 1973-1976

Doctoral Faculty, City University of New York 1970-1988

Assistant Professor of Biological Sciences, Herbert H. Lehman College, City University of NY 1967-1973

PROFESSIONAL RECOGNITION AND AWARDS

Hubert W. Vogelmann Award for Excellence in Research and Scholarship, University of Vermont

2013

Environmental Mutagen Society Award for Fundamental Studies on Repair of DNA Damage

Caused by Environmental Agents, and for her Exemplary Leadership in Science 2012

University of Vermont, College of Agriculture and Life Sciences Commencement Speaker 2012

Keynote Lecturer to Scholars in Training Symposium Honoring Women in

Radiation Research, International Congress of Radiation Research, Warsaw 2011 University Distinguished Professor, University of Vermont 2011-present

Keynote Address, FEBS Genome Instability and DNA Repair Conference

2011

Keynote Address, International Conference on DNA Repair and Mutagenesis 2009

Keynote Address, International Meeting on Radiation Damage to DNA 2006

John B. Little Award for Outstanding Contributions to Molecular Radiobiology,

Harvard School of Public Health 2005

Phi Beta Kappa, Honorary 2005

University of Vermont Scholar 1997

Keynote Speaker, Sealy Center for Molecular Sciences, San Antonio, Texas 1997

Failla Awardee and Memorial Lecturer, Radiation Research Society 1996

Member and Treasurer, Vermont Academy of Sciences and Engineering 1995-present

Gordon Mutagenesis Conference, Vice Chair, Chair (elected) 1996, 1998

Susan S. Wallace, Ph.D.

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NIH Merit Award 1995-2003

Leonard J. Tolmach Memorial Lecturer, Washington University, St. Louis 1995

Herbert M. Parker Memorial Lecturer for Outstanding Achievement in Radiation Protection 1995

Plenary Lecturer, Environmental Mutagen Society 1993

President, Radiation Research Society (elected) 1991-1992

Lucille P. Markey Charitable Trust Award to establish a Center for Molecular Genetics

at the University of Vermont 1990

NIH Merit Award 1986-1994

Memorial Sloan-Kettering Cancer, Aaron Bendich Award for Distinguished Achievement in

Biomedical Research 1984

Mary Ann Swetland Visiting Professor and Memorial Lecturer, Case Western Reserve University 1982

American Cancer Society Scholar 1974-1975

NIH Post-Doctoral Fellow, Department of Microbiology, College of Physicians & Surgeons,

Columbia University 1965-1967

NIH Pre-Doctoral Fellow, Department of Biophysics, Cornell University Graduate

School of Medical Sciences, Sloan Kettering Division 1962-1965

Atomic Energy Commission Fellow, Department of Biophysics, University of California, 1959-1961

Berkeley

Woodrow Wilson Honorary National Fellow 1959-1960

GOVERNMENT SERVICE AND ADVISORY COMMITTEES

Member, NCI Outstanding Investigator Award Review Committee 2015

Member, International Scientific Committee, 13th International Workshop

“Radiation Damage to DNA” 2014

Member, NIEHS Conference Review Committee 2012





Member, NCI Review Group, Manpower and Training 2008



Member, Program Committee, 13th International Congress of Radiation Research,

San Francisco, California 2007

Member, NIH Special Emphasis Panel/Biophysics 2006



Member, International Advisory Committee to “Great South West”

Canceropôle, City of Toulouse, France 2005-2010

Member, Program Committee, US/EU Workshop, “Systems Level Understanding

of DNA Damage Responses 2005

Member, NASA Review Panel for Radiation Research 2004

Member, Advisory Board, Structural Biology of DNA Repair,

University of California, Lawrence Berkeley Laboratory 2003-present

Member, External Review Committee, Department of Microbiology

and Molecular Genetics, New Jersey Medical School 2002

Member, Board of Directors, FASEB 2000-2003

Member, NCI Study Section Boundary Team 2001


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Member, NASA Radiobiology External Review Panel 2001

Member, FASEB Federal Funding Consensus Conference 2000, 2001

Member, Scientific Advisory Board, VIIth International Workshop on Radiation Damage to DNA 2001

Working Group Leader, National Research Council Workshop:

Biologically-Based Risk Model for Low Dose/Low Dose Rate High LET Radiation 1996

Member, Board of Scientific Counselors of the Division of Cancer Etiology, NCI 1995

Member, Biological and Environmental Research Advisory Committee, Department of Energy 1994-1999

Member, National Academy of Sciences Board on Radiation Effects Research, 1994-1998

National Research Council, National Academy of Sciences

Member, External Review Committee, Department of Microbiology, 1994

Medical University of South Carolina

Member, Vermont Technology Council Subcommittee on Vermont EPSCoR 1994-present

Member, External Advisory Board, NIEHS Institutional NRSA Training Grant,

Harvard School of Public Health 1994-2012

Program Committee, International Congress of Radiation Research, Wurtzburg, Germany 1992-1995

Member, NASA Space Radiation Health Discipline Working Group 1992-1996

Member, Scientific Committee, 18th L.H. Gray Conference, Bath, UK 1992-1994

Member, Scientific Advisory Board, Fanconi Anemia Research Fund 1992-2000

Organizing Committee, Genomics Technology and Mutational Analysis, Department of Energy 1992

Member, External Review Panel, Laboratory of Toxicology, Harvard School of Public Health 1991

Member, External Advisory Committee, Harvard School of Public Health, NIEHS Center 1991-2008

Consultant, Bio-Tek Instruments, Winooski, Vermont 1991-1993

Member, New England Land-Grant Colleges, Biotechnology Council 1990-1995

Member, New England Governors Council Biotechnology Advisory Panel 1990-1995

Member, Joint University of Vermont/City of Burlington Task Force

on Biotechnology 1990

Consultant, DuPont-Merck 1988-1996

Department of Energy HERAC Subcommittee, Radiation Biology 1985-1987

Member, External Review Panel, Chair of Therapeutic Radiology, Yale University,

School of Medicine 1984

Invited Participant, President's Cancer Panel 1983

Member, Congressional Committee for Determining Strategy

for Assessing Biological Effects of Ionizing Radiation 1979-1980

Panel Member, Review Life Sciences Program, Department of Energy 1978-1979

Member NIH Radiation Study Section 1977-1981

Ad Hoc Reviewer, NIH, DOE, National Science Foundation, American Cancer Society 1977-present

EDITORIAL BOARD SERVICE

Journal of Cellular Physiology 2010 - present

Journal of Biological Chemistry (Editorial Board) 2005 - 2010

DNA Repair (Associate Editor) 2004 - present

Molecular Cancer Research (Associate Editor) 2003 - present

Radiation Research (Senior Editor) 2001 - 2010

Environmental Health Perspectives (Associate Editor) 2000 - 2008

Mutation Research/DNA Repair (Editorial Board) 2000 - 2004

Chemical Research in Toxicology (Associate Editor) 1999 - 2002

Cell Biology and Toxicology (Associate Editor) 1984 - 1994

Mutation Research (Associate Editor) 1990 - 2000


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Radiation Research (Associate Editor) 1980 - 1983

SCIENTIFIC CONFERENCES ORGANIZED

Organizer, AACR Special Conference: Radiation Biology and Cancer:

From Molecular Responses to the Clinic 2004

Co-Organizer, ASM Conference on DNA Repair and Mutagenesis 2004

Chair, NCI Workshop on Radiation Sensitivity, Cancer Susceptibility

and Common DNA Repair Polymorphisms 2001

Co-Organizer, ASM Conference on DNA Repair and Mutagenesis 1999

NIH/DOE Workshop, Cellular Responses to Low Doses of Ionizing Radiation 1999

Conference Vice-Chair, Chair, Gordon Mutagenesis Conference 1996, 1998

Chair, NCI Workshop: “Molecular Biology to Radiation Oncology” 1997

Fanconi Anemia Research Fund, Symposium Chair: “Hematopoiesis, Oncogenesis,

DNA Damage and Repair” 1995

Chair, NCI Workshop: “Mechanisms of Transmissible Genomic Instability from

the Exposure of Mammalian Cells to Ionizing Radiation” 1995

Conference Co-Organizer, New York Academy of Sciences Conference:

"DNA Damage: Effects on DNA Structure and Protein Recognition" 1993

Organizer, UCLA Winter Symposium"Ionizing Radiation Damage to DNA: Molecular Aspects". 1990

PROFESSIONAL SOCIETIES

American Society for Biological Chemistry and Molecular Biology 1967-present

Radiation Research Society 1971-present

Past-President, Council Member 1993-1998

President 1991-1992

President-elect 1990-1991

Founder, Committee on Women’s Issues in the Radiation Research Society 1991

Councilor, Radiation Research Society 1988-1990

Editor and Founder, Radiation Research Newsletter 1984-1987

Member Program Committee

Member Site-Selection Committee

American Society for Microbiology 1973-present

Environmental Mutagen Society 1993-present

Council Member 2012-2016

American Association for Cancer Research 2002-present

Co-Chair, Carcinogenesis Subcommittee, 2002 AACR Program Committee 2002

American Association for the Advancement of Science 1965-present

American Women in Science 1972-present

Sigma Xi 1976-present

CURRENT RESEARCH SUPPORT

NIH P01 CA098993/6-10 (Wallace, S.S., P.I.) 09/01/2010-08/31/15 $9,417,271

Structure and Function of DNA Repair Enzymes



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Structure and Function of DNA Repair Enzymes - Project 5

NIH R01 CA52040 (Wallace, S. S. and Doublié, S., Co-P.I.) 01/01/13-12/31/17 $1,993,947

Processing of Free Radical Radiation Damage by Human DNA Polymerases

Completed

NIH R01 CA52040 (Wallace, S. S. and Doublié, S., Co-P.I.) 08/29/07-04/30/12 $1,645,700

Processing of Damage by Translesion DNA Synthesis

NIH R01 CA33657/23-27 (Wallace, S.S., P.I.) 08/20/2004-07/31/11 $2,269,086

Repair of DNA Damage by Ionizing Radiation


Structure, Function, and Evolution of DNA Repair Enzymes

DOE DE-FG02-00ER45828(Wallace, S.S., P.I.) 07/01/00 – 04/30/07 $2,250,000

DOE EPSCoR Initiative in Structural Biology and Computational Biology Bioinformatics

NIH 5P30 CA22435 (Yandell, D., P.I.) 12/01/00-11/30/06

Cancer Center Support Grant, Director, Genome Stability and Expression Program

DOE DE-FG02-01ER63210 (Wallace, S.S., P.I.) 09/01/00-08/31/05 $175,842

Damage Recognition, Protein Signaling, and Fidelity in Base Excision Repair

NIH/NCI R37 CA 33657(Wallace, S.S., P.I.) 02/21/95-11/30/04 $2,672,126

Repair of DNA Damage Induced by Ionizing Radiation


Free Radical DNA Damage Produced Endogenously and by Low Dose Radiation in Human Cells:

Quantitation, Consequences and Repair

NIH R01 AG17101-01 (Wallace, S.S., P.I.) 09/01/99-08/31/02 $339,746

Oxidative DNA Damage, Transcription, Repair and Aging


Structure/Function Analysis of DNA-glycosylases that Repair Oxidized Purines and Pyrimidines and

the Influence of Surrounding DNA Sequence on their Interactions

Lucille P. Markey Charitable Trust 10/15/90-11/14/95 $2,300,000

Development of a Program in Molecular Genetics.

DOE-DE-FG05-90ER75578 09/18/90-09/17/93 $123,186

Modeling/Imaging Facility for the Study of DNA Damage and Repair

TEACHING EXPERIENCE

Fifteen graduate students have completed their dissertations in the Wallace laboratory; one is currently in

training. Over 30 postdoctoral research associates, fellows and visiting senior scientists have participated

in the Wallace research program.

Courses Taught

Cell and Molecular Biology (Medical) 2003-present

Cancer Biology, University of Vermont (Graduate) 2001-present

Protein-Nucleic Acid Interactions, University of Vermont (Graduate) 1991-2001


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Prokaryotic Genetics, University of Vermont (Undergraduate) 1989-2009

Medical Microbiology, New York Medical College 1976-1988

Virology, New York Medical College (Graduate) 1983

DNA Repair, New York Medical College (Graduate) 1979

Virology, Herbert H. Lehman College, City University of New York

& New York Medical College (Graduate) 1967-1976

Molecular Biology, Herbert H. Lehman College, City University of New York

& New York Medical College (Graduate) 1967-1976

Molecular Biology, Herbert H. Lehman College, CUNY (Undergraduate) 1967-1976

Principles of Biology, Herbert H. Lehman College, CUNY (Undergraduate) 1965-1976

PH.D. STUDENTS TRAINED

Robert J. Melamede, year degree conferred: 1980, Thesis title: "DNA Synthesis in the Non-lethal

Recombination Repair Deficient x and y Mutants of Bacteriophage T4"

Former Position: Professor and Chair, Department of Biology, University of Colorado, Colorado

Springs, Retired

Paul R. Armel, year degree conferred: 1982, Thesis title: "Purification and Properties of Apurinic

Endonucleases from Saccharomyces cerevisiae"

Present Position: Senior Information Scientist, Hoffmann-LaRoche, Inc. Nutley, New Jersey

Elizabeth Moran, year degree conferred: 1983, Thesis title: "Role of Specific DNA base Damages in the

Biological Inactivation of X-irradiated Bacteriophage PM2"

Present Position: Professor of Biochemistry and Molecular Biology and Fred F. Buechel Professor for

Orthopedic Research, Orthopedics, University of Medicine and Dentistry of New Jersey

Bradley Zerler, year degree conferred: 1983, Thesis title: "Isolation and Characterization of Repair

Deficient Mutants of Alteromonas espejiana"

Present Position: Vice President for Research, Collagenix Pharmaceuticals, Newton, Pennsylvania

Harold Katcher, year degree conferred: 1984, Thesis title: "Purification and Characterization of the

Escherichia coli X-ray Endonuclease"

Present Position: Research Scientist, Myriad Diagnostics, Salt Lake City, Utah

Michael Laspia, year degree conferred: 1987, Thesis title: "Cellular Repair of Unique DNA Base Damages

in Escherichia coli".

Present Position: Associate Professor, Dartmouth Medical School, Hanover, New Hampshire

Margaret Maccabee, year degree conferred: 1992, Thesis title: "The Mutagenic Consequences of

Fragmentation Products of DNA Thymine".

Present Position: Associate Director of Nursing, Sarah Neuman Nursing Home Health Care, Charge of

Infection, Westchester County, New York.

Dongyan Jiang, year degree conferred: 1996, Thesis title: “Biological Function of Escherichia coli

Endonuclease VIII”.

Present Position: Senior Scientist at Biosource International, Boston, Massachusetts.

Christine Gifford: year degree conferred: 2000, Thesis title: “Regulation of Base Excision Repair Enzymes

in Escherichia coli”.

Ning Yang: year degree conferred: 2005, Thesis title: “Processing of Multiply Damaged Sites in Human

Cells”.

Present Position: Research Associate at the University of Wisconsin

Matthew Hogg: year degree conferred: 2005, Thesis title: “Error Detection by the Replicative DNA

Polymerase from Bacteriophage RB69”.

Present Position: President, Green Mountain Editing Services, Burlington, Vermont


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Yin Guo: year degree conferred: 2010, Thesis title: “Characterization of Three Fpg/Nei Family Members

in Mycobacterium tuberculosis”.

Present Position: Research Associate, Center for Stem Cell Biology and Regenerative Medicine, Dept

of Pediatrics, University of Maryland, Baltimore, Maryland.

Ian Odell: year degree conferred: 2011, Thesis title: “Recognition of Oxidized Pyrimidines in Nucleosomes

by Human DNA Glycosylases

Present Position: Resident, Yale University College of Medicine, New Haven, Connecticut

Minmin Liu: year degree conferred: 2012, Thesis title: “Functional and Structural Studies of DNA Repair

Glycosylase Neil3.”

Present Position: Research Associate, Van Andel Research Institute, Grand Rapids, Michigan

Andrew Dunn: year degree conferred: 2012, Thesis title: “Single Molecule Observations of DNA Repair

Glycosylases”.

Present Position: Physicians Choice Laboratory Services, Boston, Massachusetts

Jia Zhou: year degree conferred: 2015, Thesis title: DNA Glycosylases Remove Oxidized Base Damages

from G-Quadruplex DNA Structures

POSTDOCTORAL ASSOCIATES

Sheila Jacobs, Ph.D., Columbia University, Microbiology; 1973 - 1982.

Former Position: Director, Molecular Genetics, Schering Corp., Bloomfield, NJ, Retired

Gary Strniste, Ph.D., Pennsylvania State University, Biophysics; 1974 - 1976.

Former Position: Group Leader, Molecular Radiobiology, Los Alamos National Laboratory, Retired

Joanne DeVries, Ph.D., Columbia University, Biological Sciences; 1978 - 1982.

Former Position: Director, Microbiology, Schering Corp., Bloomfield, NJ, Retired

Yoke Wah Kow, Ph.D., Brandeis University, Biochemistry; 1983 - 1986.

Former position: Professor, Division of Cancer Biology, Radiation Oncology, Emory University,

Atlanta, GA, Retired

Haimei Huang, Ph.D., Louisiana State University, Genetics; 1983 - 1986.

Present Position: Professor, National Tsing University, Hua, Taiwan

Hiroshi Ide, Ph.D., Kyoto University, Chemistry; 1983 - 1988

Present Position: Professor, Graduate Dept. of Gene Science, Hiroshima University, Japan

Lynn Petrullo, Ph.D., New York Medical College, Microbiology; 1985 - 1987

Present Position: Professor and Chair, Department of Biology, College of New Rochelle, New

Rochelle, NY

Karen Hubbard, Ph.D., Illinois Institute of Technology, Biology; 1986 - 1988

Present Position: Professor, City College, CUNY

Seyma Ogut, Ph.D., University of Ankara, Biochemistry; 1987 - 1988

Kihei Kubo, Ph.D., Hokkaido University, Radiation Biology; 1987 - 1989

Present Position: Professor, Osaka University, Osaka, Japan

Janet Evans, Ph.D., University of Wales, Microbiology; 1989 - 1992

Present Position: Research Scientist, Division of Bacteriology, NIBSC, Hertfordshire, England

Zafer Hatahet, Ph.D., McGill University, Biochemistry; 1990 - 1995

Present Position: Professor and Chair, Department of Biology, Northwestern State University of

Louisiana

Mary Glackin, Ph.D., Wesleyan University, Molecular Biology and Biochemistry; 1990 – 1995

Present Position: Computational Biologist, Mount Holyoke College, South Hadley, Massachusetts

Andrei Purmal, Ph.D., Moscow State University, Chemistry; 1990 - 1997

Present Position: Director of Chemistry, Cleveland Biolabs


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Lynn Harrison, Ph.D., University of Manchester, Oncology; 1995 - 1997

Present Position: Professor, Department of Physiology, Louisiana State University Medical Center,

Shreveport, LA

Robert Hoepfner, Ph.D., University of Cincinnati, Molecular Genetics; 1993 - 1998

Present Position: Research Associate, Ohio State University

Cindy Harrington, Ph.D., Wake Forest University, Biochemistry; 1995 - 1998

Ivan Bespalov, Ph.D., Belarussian State University, Bioorganic Chemistry; 1993 – 2003

Present Position: Associate Research Scientist, New York University Medical Center, New York

Viswanath Bandaru, Ph.D., Case Western Reserve University; 1998 – 2003

Present Position: Senior Scientist/Mylan Pharmaceuticals, Morgantown, West Virginia

Scott Kathe, Ph.D., Rensselaer Polytechnic Institute; 1998 – 2005

Present Position: Research/Analyst, Microbiology and Molecular Genetics, University of Vermont

Masaaki Inoue, M.D., Ph.D., University of Occupational and Environmental Health, Japan; 2000 – 2002

Present Position: Department of Thoracic Surgery, Shu-Kokura Hospital, Kitakyushu, Japan

Satoshi Matsuyama, Ph.D., Osaka Prefecture University, Japan; 2001 – 2002

Present Position: Associate Professor, Osaka Prefecture University, Japan.

Alan Chant, Ph.D., University of Portsmouth, United Kingdom; 2001-2005

Present Position: Department of Chemistry and Biochemistry, Clarion University, Pennsylvania

Muhammad Ahmad Chaudhry, Ph.D., University of Manchester, United Kingdom; 2002 – 2004

Present Position: Associate Professor, Medical Laboratory and Radiation Science, University of

Vermont

Takashi Watanabe, Ph.D., Tohoku University, Japan; 2002 – 2005

Present Position: Research Scientist, RIKEN Institute, Yokohama, Japan

Stephanie Duclos, Ph.D., University of Orleans, France; 2005 – 2011

Present Position: Senior Scientist, Structural Biology Group, Abingdon, United Kingdom.

Andrea Lee, Ph.D., University of Wisconsin-Madison, Madison, Wisconsin, 2011 - present

Carolyn Marsden, Ph.D., Tulane University, New Orleans, Louisiana, 2012 - present

ACADEMIC SERVICE

University of Vermont:

Member Search Committee, Dean, Rubenstein School of Environment and

Natural Resources 2013-2014

Member, FTARS Finance Management, College of Medicine 2013-2014

Member of University of Vermont Scholars and Distinguished Professors’

Strategic Initiative Project Committee 2012-present

Member, LCME Self-Study Committee on Medical Education 2012-2013

Chair, Search Committee, Department of Biochemistry 2010-2011

Chair, Review Committee, Department of Nutrition and Food Sciences Chair 2009

Member, Committee on Research Directions for the College of Medicine 2008

Chair, Review Committee, Department of Plant Biology Chair 2007

Member, Vermont Cancer Center Transition Steering Committee 2006-2012

Member, Instructional Improvement Committee, College of Medicine 2005-2007

Member, LCME Self Study Subcommittee V on Educational Resources 2004-2005

Member, University of Vermont Biology Restructure Task Force 2002-2004

Member, Vermont Integrated Curriculum Implementation Team 2001-2003

Member, Vermont Integrated Curriculum Board of Directors 2003-2005

Member, Provost’s Task Force on the Biological Sciences 2001-2003

Member, Space Allocation Committee, College of Medicine 2000-2001


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Member, Search Committee, Program Leader, Human Genetics Program 2000-2001

Member, Review Committee, Department of Community Development and

Applied Economics Chair 2000

Member, College of Agriculture and Life Sciences Workshop on Genetically Modified Organisms 1998

Member, Vermont Cancer Center Institutional Advisory Board 1995-present

Member, College of Medicine, Hughes Initiative Advisory Board 1995-2000

Member, Structural Biology Initiative, College of Medicine and

DOE Vermont EPSCOR 1995-2007

Member, Review Committee, Dean, College of Engineering and Mathematics 1994-1995

Member, Provost's Task Force on Environmental Initiatives 1993-1994

Member, VCC Executive Committee 1993-present

Director, Genome Stability and Expression Scientific Program,

Vermont Cancer Center 1993-2012

Chairperson, Search Committee for Cancer Center Director 1992-1993

Director, DNA Damage and Repair Scientific Core, Proposed

Environmental Health Sciences Center 1993

Member, University Planning Council 1990-1991

Member, Review Committee, Department of Electrical Engineering

and Computer Sciences Chair 1991

Member, Division of Health Sciences Organizational Review Committee 1990

Search Committee, Director of Sponsored Programs 1990

College of Medicine Advisory Council 1988-present

Dean's Council, College of Agriculture and Life Sciences 1988-present

New York Medical College:

Graduate Program Director, Department of Microbiology

Graduate Faculty Council

Financial Aid Committee

Faculty Research Committee

Chairman, Student Research Awards Committee

Master Plan Committee

Member, Center for Aging and Adult Development

Search Committee, Dean

Chairman, Committee to Develop Molecular Biology Degree Program

Herbert H. Lehman College, CUNY:

Curriculum Committee

Graduate Committee

Molecular Biology Doctoral Exam Committee, Chair 1974 - 1976

City University of New York Faculty Research Awards Committee

PUBLICATIONS

Wallace, S.S., Erlanger, B.F. and Beiser, S.M. (1969). Antibodies to ribosides: Effect on in vitro priming

ability of DNA. Journal of Molecular Biology 43:41-49.

Wallace, S.S. and Van Dyke, J.G. (1970). The effect on X-irradiation on gene function in bacteriophage

T4. Radiation Research 43:379-392.


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Wallace, S.S., Erlanger, B.F. and Beiser, S.M. (1971). Immunochemical studies on dinucleoside

phosphate-protein conjugates. Biochemistry 10:679-683.

Wallace, S.S. and Melamede, R.J. (1972). Host- and phage-mediated repair of radiation damage in

bacteriophage T4. Journal of Virology 10:1159-1169. PMCID: PMC356597

Strniste, G. and Wallace, S.S. (1974). Excision of X-irradiated DNA; a possible first step in the repair of

X-ray induced damages. Radiation Research 59:98.

Strniste, G. and Wallace, S.S. (1975). "An Escherichia coli endonuclease which acts on X-irradiated

DNA", Basic Life Science 5A:201-204.

Strniste, G. and Wallace, S.S. (1975). Endonucleolytic incision of X-irradiated deoxyribonucleic acid by

extracts of Escherichia coli. Proceedings of the National Academy of Sciences USA 72:1997-2001. PMCID:

PMC432679

Katcher, H.L. and Wallace, S.S. (1976). Partial purification of the X-ray endonuclease of Escherichia coli.

Radiation Research 67:573.

Strniste, G. Armel, P.R. and Wallace, S.S. (1977). Rate of formation of X-ray induced sites in

deoxyribonucleic acid sensitive to incision by extracts of Escherichia coli. Radiation Research 62:573.

Armel, P.R., Strniste, G. and Wallace, S.S. (1977). Studies on Escherichia coli X-ray endonuclease

specificity: Roles of hydroxyl and reducing radicals in the production of DNA lesions. Radiation Research

69:328-338.

Melamede, R.J. and Wallace, S.S. (1977). Properties of the nonlethal recombinational repair x and y

mutants of bacteriophage T4. II DNA synthesis. Journal of Virology 24:28-40. PMCID: PMC515907

Vicuna, R., Hurwitz, J. Wicker, S., Wallace, S.S. and Girard, M. (1977). In vitro DNA synthesis dependent

on ØX-174 compared with fd DNA. I: Protein requirements for selective inhibition. Journal of Biological

Chemistry 252:2524-2533.

Katcher, H.L. and Wallace, S.S. (1978). The production of alkali-labile sites in X-irradiated DNA.

International Journal of Radiation Biology 34:497-500.

Melamede, R.J. and Wallace, S.S. (1978). The effect of exogenous deoxyribnucleosides on thymidine

incorporation in T4-infected cells. FEBS Letters 87:12-16.

Wallace, S.S., Armel, P.R. and Katcher, H.L. (1978). "Enzymatic recognition of DNA damages induced

by ionizing radiation", in DNA Repair Mechanisms, P. Hanawalt and E. Friedberg eds., Academic Press,

p. 23.

Armel, P.R. and Wallace, S.S. (1978). Apurinic endonucleases from Saccharomyces cerevisiae. Nucleic

Acids Research 5:3347-3356. PMCID: PMC342254

Zerler, B.R. and Wallace, S.S. (1979). Repair of psoralen plus near ultraviolet light damage in

bacteriophage T4. Photochemistry and Photobiology 30:413-416.

Melamede, R.J. and Wallace, S.S. (1980). Studies on the non-lethal recombination repair deficient mutants

of bacteriophage T4. III DNA replicative intermediates and T4w. Molecular and General Genetics

177:501-509.

Margulies, L. and Wallace, S.S. (1980). Drosophila melanogaster endonuclease activity which recognizes

damaged DNA substrates. Radiation Research 83:424.

Moran, E., Zerler, B.R. and Wallace, S.S. (1980). Correlation of thymine ring saturation products with

biological activity in bacteriophage PM2 DNA. Radiation Research 83:412.


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Melamede, R.J. and Wallace, S.S. (1980). Phenotypic differences among the alleles of the T4

recombination defective mutants. Molecular and General Genetics 179:327-330.

Wallace, S.S., Katcher, H.L. and Armel, P.R. (1981). "The measurement of X-ray damage in supercoiled

DNA by means of enzyme probes". Chapter 11 in DNA Repair, A Laboratory Manual of Research

Procedures, E. Friedberg and P. Hanawalt, eds., p. 113.

Zerler, B.R., Moran, E. and Wallace, S.S. (1981). Isolation and characterization of UV-sensitive mutants

of Alteromonas espejiana, the host for PM2 bacteriophage. Radiation Research 87:485.

DeVries, J. and Wallace, S.S. (1982). Reversion of bacteriophage T4rII mutants by high levels of

pyrimidine deoxyribonucleosides. Molecular and General Genetics 186:101-105.

Katcher, H.L. and Wallace, S.S. (1982). Properties of purified preparations of the Escherichia coli X-ray

endonuclease. Radiation Research 81:86.

Melamede, R.J. and Wallace, S.S. (1983). Incorporation of thymine-containing DNA precursors in wild-

type and mutant T4-infected plasmolysed cells. Molecular and General Genetics 191:382-388.

Melamede, R.J. and Wallace, S.S. (1983). Incorporation of thymine-containing DNA precursors in

plasmolysed cells infected by the T4 non-lethal recombination defective mutants. Molecular and General

Genetics 191:389-392.

Bernstein, C. and Wallace, S.S. (1983). "DNA Repair", Chapter 14 in The Bacteriophage T4, C.K.

Mathews, E.M. Kutter, G. Mosig, and P.B. Berget, eds., ASM Press, Washington, p. 138-151.

Wallace, S.S. (1983). Detection and repair of DNA base damages produced by ionizing radiation.

Environmental Mutagenesis 5:769-788.

DeVries, J.K. and Wallace, S.S. (1983). Expression of cloned bacteriophage T4 uvsw and uvsy genes in

rec+ and rec- Echerichia coli. Journal of Virology 47:406-412. PMCID: PMC255281

Erlanger, B.F., Miller, O.J., Rajagopalan, R. and Wallace, S.S. (1983). "Immunological approaches for

detection of DNA modified by environmental agents", in Application of Biological Markers to Carcinogen

Testing, Vol. 29, Environmental Science Research, H.A. Milman and S. Sell, eds., Plenum Press, N.Y. p.

325.

DeVries, J.K., Laspia, M.F. and Wallace, S.S. (1983). "Expression of cloned bacteriophage T4 uvsw and

uvsy recombination repair genes", in Cellular Responses to DNA Damage, E.C. Friedberg and B.A.

Bridges, eds., Alan R. Liss, N.Y. p.429.

Katcher, H.L. and Wallace, S.S. (1983). Characterization of the Escherichia coli X-ray endonuclease,

endonuclease III. Biochemistry 22:4071-4081.

Rajagopalan, R., Melamede, R.J., Laspia, M.F., Wallace, S.S. and Erlanger, B.F. (1984). Properties of

antibodies to thymine glycol, a product of the radiolysis of DNA. Radiation Research 97:499-510.

Zerler, B.R. and Wallace, S.S. (1984). Repair-defective mutants of Alteromonas espejiana, the host for

bacteriophage PM2. Journal of Bacteriology 157:465-474. PMCID: PMC215271

Margulies, L. and Wallace, S.S. (1984). Developmental pattern and properties of apurinic activity in

Drosophila melanogaster. Cell Biology and Toxicology 1:127-143.

Armel, P.R. and Wallace, S.S. (1984). DNA repair in Saccharomyces cerevisiae: Purification and

characterization of apurinic endonuclease activities. Journal of Bacteriology 160:895-902. PMCID:

PMC215794


12

Melamede, R.J. and Wallace, S.S. (1985). "A possible secondary role for thymine-containing DNA

precursors", in The Genetic Consequences of Nucleotide Pool Imbalance, F. de Serres, ed., Basic Life

Science Series, Plenum Press, N.Y. p.67-102.

Moran, E., and Wallace, S.S. (1985). The role of specific DNA base damage in the X-ray-induced

inactivation of PM2 bacteriophage. DNA Repair Reports, Mutation Research 146:229-241.

Kow, Y.W. and Wallace, S.S. (1985). Exonuclease III recognizes urea residues in oxidized DNA.

Proceedings of the National Academy of Sciences USA 82:8354-8358. PMCID: PMC390914

Ide, H., Kow, Y.W. and Wallace, S.S. (1985). Thymine glycols and urea residues in M13 DNA constitute

replicative blocks in vitro. Nucleic Acids Research 13:8035-8052. PMCID: PMC322108

Margulies, L., Briscoe, D.I. and Wallace, S.S. (1986). The relationship between radiation-induced and

transposon-induced genetic damage during Drosophila oogenesis. Mutation Research 162:55-68.

Ide, H., Melamede, R.J. and Wallace, S.S. (1987). Synthesis of dihydrothymidine and thymine glycol

triphosphates and their ability to serve as substrates for Escherichia coli DNA polymerase I. Biochemistry

26:964-969.

Chang, C.C., Kow, Y.W. and Wallace, S.S. (1987). Apurinic endonucleases from Saccharomyces

cerevisiae also recognize urea residues in oxidized DNA. Journal of Bacteriology 169:180-183. PMCID:

PMC211750

Wallace, S.S. (1987). Biological consequences of oxidative DNA damage. British Journal of Cancer 55,

Suppl. VIII:118-128. PMCID: PMC2149446

Margulies, L., Briscoe, D. and Wallace, S.S. (1987). The relationship between radiation-induced and

transposon-induced genetic damage during Drosophila spermatogenesis. Mutation Research 179:183-195.

Jorgensen, T.J., Kow, Y.W., Wallace, S.S. and Henner, W.D. (1987). Mechanism of action of Micrococcus

luteus gamma endonuclease. Biochemistry 26:6436-6443.

Kow, Y.W. and Wallace,S.S. (1987). Mechanism of action of Escherichia coli endonuclease III.

Biochemistry 26:8200-8206.

Ide, H., Melamede, R.J., Kow, Y.W. and Wallace, S.S. (1987). "Incorporation of dihydrothymidine

triphosphate during DNA replication: An implication for the biological consequence of thymine C5 - C6

bond saturation", in Anticaricinogenesis and Radiation Protection, P. Cerutti, O. Nygaard and M. Simic,

eds., Plenum Press, New York, p.145-150.

Melamede, R.J., Kow, Y.W. and Wallace, S.S. (1987). "The isolation and preliminary characterization of

endonuclease VIII from Escherichia coli", in Anticarcinogenesis and Radiation Protection, P. Cerutti, O.

Nygaard and M. Simic, eds., Plenum Press, New York, p.139-144.

Kow, Y.W., Ide, H. and Wallace, S.S. (1987). "Mechanism of action of exonuclease III of Escherichia

coli", in Anticarcinogenesis and Radiation Protection, P. Cerutti, O. Nygaard and M. Simic, eds., Plenum

Press, New York, p.135-138.

Hayes, R. H., Petrullo, L. A. Huang, H. Wallace, S. S. LeClerc, J. E. (1988). Oxidative damage in DNA:

Lack of mutagenicity by thymine glycol lesions. Journal of Molecular Biology 201:239-246.

Laspia, M.F. and Wallace, S.S. (1988). Excision repair of thymine glycols, urea residues and apurinic sides

in Escherichia coli. Journal of Bacteriology 170:3359-3366. PMCID: PMC211302

Wallace, S.S., Ide, H., Kow, Y.W., Laspia, M.F., Melamede, R.J., Petrullo, L.A. and LeClerc, J.E. (1988).

"Processing of oxidative DNA base damage in Escherichia coli", in Mechanisms and Consequences of


13

DNA Damage Processing, E.C. Friedberg and P. Hannawalt, eds.. Alan R. Liss, Inc., New York, p.151-

157.

Maw, H., Wallace, S.S., and Margulies, L. (1988). Radiation-induced and transposon-induced

chromosome damage in Drosophila: Translocations and transmission distortion. Radiation Research

115:503-514.

Wallace, S. S. (1988). Apurinic endonucleases and DNA glycosylases that recognize oxidative DNA

damage. Molecular Environmental Mutagenesis 12:431-477.

Ide, H. and Wallace, S.S. (1988). Dihydrothymidine and thymidine glycol triphosphates as substrates for

DNA polymerases: Differential recognition of thymine C5 - C6 double bond. Nucleic Acids Research

16:11339-11354. PMCID: PMC339014

Margulies, L., Griffith, C.S., Dooley, J.C. and Wallace, S.S. (1989). The interaction between X-rays and

transposon mobility in Drosophila: Hybrid sterility and chromosome loss. Mutation Research 215:1-14.

Hubbard, K., Huang, H., Laspia, M.F., Ide, H. Erlanger, B.F. and Wallace, S.S. (1989). Immunochemical

quantitation of thymine glycols in oxidized and X-irradiated DNA. Radiation Research 118:257-268.

Laspia, M.F. and Wallace, S.S. (1989). SOS processing of unique oxidative DNA damage in Escherichia

coli. Journal of Molecular Biology 207:53-60.

Hubbard, K., Ide, H., Erlanger, B.F. and Wallace, S.S. (1989). Characterization of antibodies to

dihydrothymine, a radiolysis product of DNA. Biochemistry 28:4382-4387.

Laspia, M.F. and Wallace, S.S. (1989). "Processing of thymine glycols, urea residues and AP sites in

Escherichia coli", in DNA Damage and Repair, A. Castellani, ed., Plenum Press, New York, pp. 299-304.

Wallace, S.S. (1989). Processing of ring saturation and fragmentation products of DNA thymine in

Escherichia coli. Annali dell'Istituto superiore di sanità 25:191-202.

Kow, Y.W., Wallace, S.S. and Van Houten, B. (1990). UvrABC nuclease complex repairs thymine glycol,

an oxidative DNA base damage. Mutation Research 235:147-156.

Wallace, S.S. and Ide, H. (1990). "Structure/function relationships involved in the biological consequences

of pyrimidine ring saturation and fragmentation products", in Ionizing Radiation Damage to DNA:

Molecular Aspects, S.S. Wallace and R. Painter, eds., Alan R. Liss, Inc., New York, pp.1-15.

Chen, B.X., Hubbard, K., Ide, H., Wallace, S.S. and Erlanger, B.F. (1990). Characterization of a

monoclonal antibody to thymidine glycol monophosphate. Radiation Research 124:131-136.

Elkind, M.M., Bedford, J.S., Benjamin, S.A., Hoover, E.A., Sinclair, W.K., Wallace, S.S. and Zimbrick,

J.D. (1991) Oncogenic mechanisms in radiation-induced cancer. Cancer Research 51: 2740-2747.

Ide, H., Petrullo, L., Z. Hatahet, and Wallace, S.S. (1991). Processing of DNA base damage by DNA

polymerases: Dihydrothymine and -ureidoisobutyric acid as models for instructive and non-instructive

lesions. Journal of Biological Chemistry 266:1469-1477.

Kow, Y.W., Faundez, G., Melamede, R.J. and Wallace, S.S. (1991). Processing of model single-strand

breaks in ØX-174 RF transfecting DNA by Escherichia coli. Radiation Research 126:357-366.

Ide, H., Kimura, Y., Murakami, A., Wallace, S.S. and Makino, K. (1991). Effects of base damages on DNA

replication. Nucleic Acids Research Symposium Series, 25:161-162.

Chen, B.X., Kubo, K., Ide, H., Erlanger, B.F., Wallace, S.S. and Kow, Y.W.(1992). Properties of a

monoclonal antibody for the detection of abasic sites, a common DNA lesion. Mutation Research, 273:253-

261.


14

Wallace, S.S., Melamede, R.J., and Kow, Y.W. (1991). “Base excision repair of radiation damage in

Escherichia coli”, in Radiation Research. A Twentieth-Century Perspective, Vol. 2, (Dewey, W.C.,

Edington, M., Fry, R.J.M., Hall, E.J., and Whitmore, G.F., eds.), Academic Press, pp. 263-267.

Kubo, K., Ide, H., Wallace, S.S. and Kow, Y.W. (1992). A novel, sensitive and specific assay for abasic

sites, the most commonly produced DNA lesion. Biochemistry, 31:3703-3708.

Kow, Y.W., Faundez, G., Hayes, S., Bonner, C., Goodman, M.F. and Wallace, S.S. (1993). Absence of a

role for DNA polymerase II in SOS-induced translesion bypass in Escherichia coli. Journal of Bacteriology

175:561-564. PMCID: PMC196174

Hatahet, Z., Purmal, A., and Wallace, S.S. (1993). A novel method for site specific introduction of single

model oxidative DNA lesions into oligodeoxyribonucleotides. Nucleic Acids Research 21:1563-1568.

PMCID: PMC309363

Evans, J., Maccabee, M., Hatahet, Z., Courcelle, J., Bockrath, R., Ide, H., and Wallace, S.S. (1993).

Thymine ring saturation and fragmentation products: Lesion bypass, misinsertion and implications for

mutagenesis. Mutation Research 299:147-156.

Bockrath, R., Kow, Y.W., and Wallace, S.S. (1993). Chemically modified apurinic sites in single-stranded

ØX 174 DNA increase mutagenesis in SOS-induced Escherichia coli. Mutation Research 288:207-214.

Purmal, A.A., Kow, Y.W., and Wallace, S.S. (1994) Major oxidative products of cytosine, 5-

hydroxycytosine and 5-hydroxyuracil, exhibit sequence context-dependent mispairing in vitro. Nucleic

Acids Research, 22:72-78. PMCID: PMC307748

Purmal, A.A., Lampman, G.W., Kow, Y.W., Wallace, S.S. (1994) The sequence context-dependent

mispairing of 5-hydroxycytosine and 5-hydroxyuridine in vitro. Annals of The New York Academy of

Sciences 726:361-363.

Maccabee, M., Evans, J., Glackin, M., Hatahet, Z., and Wallace, S.S. (1994). Pyrimidine ring fragmentation

products: Effects of lesion structure and sequence context on mutagenesis. Journal of Molecular Biology

236:514-530.

Melamede, R.J., Hatahet, Z., Kow, Y.W., Ide, H., and Wallace, S.S. (1994). Isolation and characterization

of endonuclease VIII from Escherichia coli. Biochemistry, 33:1255-1264.

Ide, H., Tedzuka, K., Shimzu, H., Kimura, Y., Purmal, A., Wallace, S.S., and Kow, Y.W. (1994). a-

Deoxyadenosine, a major anoxic radiolysis product of adenosine in DNA, is a substrate for Escherichia

coli endonuclease IV. Biochemistry, 33:7842-7847.

Glackin, M., Maccabee, M., Evans, J., and Wallace, S.S. (1994) "Sequence context effects on the mutagenic

outcome of pyrimidine ring fragmentation products: Computational analysis", in Structural Biology: The

State of the Art Volume 2, (Sarma, R.H. and Sarma, M.H., eds.), Adenine Press, New York, pp. 335-347.

Hatahet, Z., Kow, Y.W., Purmal, A.A., Cunningham, R.P., and Wallace, S.S. (1994) New substrates for old

enzymes: 5-Hydroxy-2'-deoxycytidine and 5-hydroxy-2'-deoxyuridine are substrates for Escherichia coli

endonuclease III and formamidopyrimidine DNA N-glycosylase while 5-hydroxy-2'-deoxyuridine is a

substrate for uracil DNA N-glycosylase. Journal of Biological Chemistry 269:18814-18821.

Purmal, A.A., Kow, Y.W., and Wallace, S.S. (1994) 5-Hydroxypyrimidine deoxynucleoside triphosphates

are more efficiently incorporated into DNA by exonuclease-free Klenow fragment than 8-oxopurine

deoxynucleoside triphosphates. Nucleic Acids Research 22:3930-3935. PMCID: PMC308392

Hatahet, Z., Purmal, A.A., and Wallace, S.S. (1994) Oxidative DNA lesions as blocks to in vitro

transcription by phage T7 RNA polymerase, Annals of The New York Academy of Sciences, 726:346-348.


15

Purmal, A.A., Lampman, G.W., Pourmal, E.I., Melamede, R.J., Wallace, S.S., and Kow, Y.W. (1994)

Uracil DNA-glycosylase distributively removes uracil from uracil-containing DNA. Journal of Biological

Chemistry 269:22046-22053.

Wallace, S.S. (1994). DNA damages processed by base excision repair: Biological consequences.

International Journal of Radiation Biology 66:579-589.

Ide, H., Shimizu, H., Himura, Y., Sakamoto, S., Makino, K., Glackin, M., Wallace, S.S., Nakamuta, H.,

Sasaki, M., and Sugimoto, N. (1995). Influence of a-deoxyadenosine on the stability and structure of DNA.

Thermodynamic and molecular mechanics studies. Biochemistry, 34:6947-6955.

Milligan, J.R., Hg, J.Y., Wu, C.C., Aguilera, J.A., Ward, J.F., Kow, Y.W., Wallace, S.S., and Cunningham,

R.P. (1996). Methylperoxyl radicals as intermediates in the damage to DNA irradiated in aqueous dimethyl

sulfoxide with gamma rays. Radiation Research 146:436-443.

Bespalov, I., Purmal, A., Glackin, M., Wallace, S.S., and Melamede, R.J. (1996). Recombinant Phabs

reactive with 7,8 dihydro-8-oxoguanine, a major oxidative DNA lesion. Biochemistry 35:2067-2078.

Melamede, R.J., Kow, Y.W., and Wallace, S.S. (1996). Detection of oxidative DNA base damages:

Immunochemical and electrochemical approaches. Technologies for Detection of DNA Damage and

Mutations. Gerd P. Pfeifer, Ed. Plenum Press, pp. 103-115.

Purmal, A.A., Wallace, S.S., and Kow, Y.W. (1996). The phosphodiester bond 3' to a deoxyuridine residue

is crucial for substrate binding for uracil DNA N-glycosylase. Biochemistry 35:16630-16637.

Bespalov, I., Purmal, A., Bond, J, Wallace, S.S., and Melamede, R.J. (1996). Altering the specificity of

hapten binding Fabs that recognize DNA base modifications. In Antibody Engineering: New Technology,

Application & Commercialization, (Hori, W., ed.), International Business Communications, pp. 181-198.

Wallace, S.S. (1997). “Oxidative damage to DNA and its repair” in Oxidative Stress and the Molecular

Biology of Antioxidant Defenses, (Scandalios, J., ed.), Cold Spring Harbor Press, pp. 49-90.

Jiang, D., Hatahet, Z., Blaisdell, J.O., Melamede, R.J., and Wallace, S.S. (1997). Escherichia coli

endonuclease VIII: Cloning, sequencing and overexpression of the nei structural gene and characterization

of nei and nei nth mutants. Journal of Bacteriology 179: 3773-3782. PMCID: PMC179177

Ide, H., Kow, Y.W., Chen, B-X, Erlanger, B.F., and Wallace, S.S. (1997). Antibodies to oxidative DNA

damage: Characterization of antibodies to 8-oxopurines. Cell Biology and Toxicology. 13: 405-417.

Hatahet, Z. and Wallace, S.S. (1997). “Translesion synthesis”, in DNA Damage and Repair, Vol 1: DNA

Repair in Prokaryotes and Lower Eukaryotes, (Nickoloff, J.A. and Hoekstra, M.F., eds.), Humana Press,

Inc., Totowa, NJ, pp. 229-262.

Purmal, A.A., Bond, J., Lyons, B.A., Kow, Y.W., and Wallace, S.S. (1998) Uracil glycol deoxynucleoside

triphosphate is a better substrate for DNA polymerase I Klenow fragment than thymine glycol

deoxynucleoside triphosphate. Biochemistry, 37: 330-338.

Jiang, D., Hatahet, Z., Melamede, R.J., and Wallace, S.S. (1998) Characterization of Escherichia coli

endonuclease VIII. Journal of Biological Chemistry 272: 32230-32239.

Harrison, L., Hatahet, Z., Purmal, A.A., and Wallace, S.S. (1998) Multiply damaged sites in DNA:

Interactions with Escherichia coli endonucleases III and VIII. Nucleic Acids Research 26: 932-941.

PMCID: PMC147348

Hatahet, Z., Zhou, M., Reha-Krantz, L.J., Morrical, S.W., and Wallace, S.S. (1998) In search of a mutational

hotspot. Proc. Natl. Acad. Sci., 95: 8556-8561. PMCID: PMC21114


16

Purmal, A.A., Lampman, G.W., Bond, J.P., Hatahet, Z, and Wallace, S.S. (1998) Enzymatic processing of

uracil glycol, a major oxidative product of DNA cytosine. Journal of Biological Chemistry 16: 10026-

10035.

Stone, H.B., Dewey, W.C., Wallace, S.S., Coleman, C.N. (1998) Molecular biology to radiation oncology:

a model for translational research? Opportunities in basic and translational research. Radiation Research

150: 134-147.

Wallace, S.S. Enzymatic processing of radiation-induced free radical damage in DNA. (1998) Radiation

Research 150: pp. S60-79.

Wallace, S.S., Harrison, L., Jiang, D., Blaisdell, J.O., Purmal, A.A., and Hatahet, Z. (1999) “Processing

and consequences of oxidative DNA base lesions” in DNA Damage and Repair: Oxygen Radical Effects,

Cellular Protection, and Biological Consequences, (Dizdaroglu, M., ed.), Plenum Publishing Corp., pp.

419-430.

Hatahet, Z., Zhou, M., Ide, H., Morrical, S.W., Reha-Krantz, L.J., and Wallace, S.S. (1999) In vitro

selection of sequence contexts for good and poor bypass of abasic sites and tetrahydrofuran by T4 DNA

polymerase holoenzyme. Journal of Molecular Biology 286: 1045-1057.

Banáth, J.P., Wallace, S.S., Thompson, J., and Olive, P.L. (1999) Radiation-induced DNA base damage

detected in individual aerobic and hypoxic cells with endonuclease III and formamidopyrimidine-

glycosylase. Radiation Research 151: 550-558.

You, H.J., Swanson, R.L., Harrington, C., Corbett, A.H., Jinks-Robertson, S., Sentürker, S., Wallace, S.S.,

Boiteux, S., Dizdaroglu, M., and Doetsch, P.W. (1999) Saccharomyces cerevisiae Ntg1p and Ntg2p: Broad

specificity N-glycosylases for the repair of oxidative DNA damage in the nucleus and mitochondria.

Biochemistry 38:11298-11306.

Gifford, C.M., and Wallace, S.S. (1999) The genes encoding formamidopyrimidine and MutY DNA

glycosylases in Escherichia coli are transcribed as part of complex operons. Journal of Bacteriology

181:4223-4236. PMCID: PMC93923

Harrison, L., Hatahet, Z., and Wallace, S.S. (1999) In vitro repair of synthetic ionizing radiation-induced

multiply damaged DNA sites. Journal of Molecular Biology 290:667-684.

Blaisdell, J.O., Hatahet, Z., and Wallace, S.S. (1999) A novel role for Escherichia coli endonuclease VIII

in the prevention of spontaneous GT transversions. Journal of Bacteriology 181:6396-6402. PMCID:

PMC103775

Bespalov, I., Bond, J., Purmal, A., Wallace S.S., and Melamede, R.J. (1999) Fabs specific for 8-oxoguanine:

Control of DNA binding. Journal of Molecular Biology 293:1085-1095.

Gifford, C.M., and Wallace, S.S. (2000) The genes encoding endonuclease VIII and endonuclease III in

Escherichia coli are transcribed as the terminal genes in operons. Nucleic Acids Research 28:762-769.

PMCID: PMC102543

Harrison, L., Blaisdell, J.O., Hatahet, Z., and Wallace, S.S. (2000) “Base excision repair processing of X-

ray-induced free radical DNA damage” in Radiation Research Volume 2: Proceedings of the Eleventh

International congress of Radiation Research, Dublin, Ireland, July 18-23, 1999, (Moriarty, M., Mothersill,

C., Seymour, C, Edington, M., Ward, J.F., and Fry, R.J.M., eds.) Allen Press, Inc., pp. 382-385.

Soultanakis, R.P., Melamede, R.J., Bespalov, I.A., Wallace, S.S., Beckman, K.B., Ames, B.N., Taatjes,

D.J., and Janssen-Heininger, Y.M.W. (2000) Fluorescence detection of 8-oxoguanine in nuclear and

mitochondrial DNA of cultured cells using a recombinant Fab and confocal scanning laser microscopy.

Free Radcial Biology and Medicine 28: 987-998.


17

Gifford, C.M., Blaisdell, J.O., and Wallace, S.S. (2000) Multiprobe RNase protection assay analysis of

mRNA levels for the Escherichia coli oxidative DNA glycosylase genes under conditions of oxidative

stress. Journal of Bacteriology 182:5416-5424. PMCID: PMC110984

Buchko, G.W., Hess, N.J., Bandaru, V., Wallace, S.S., and Kennedy, M.A. (2000) Spectroscopic studies of

zinc (II)- and cobalt (II)-associated Escherichia coli formamidopyrimidine-DNA glycosylase: extended X-

ray absorption fine structure evidence for a metal-binding domain. Biochemistry, 39:12441-12449.

Potts, R.J., Bespalov, I.A., Wallace, S.S., Melamede, R.J., and Hart, B.A. (2001) Inhibition of oxidative

DNA repair in cadmium-adapted alveolar epithelial cells. Toxicology, 161:25-38.

Blaisdell, J.O., and Wallace, S.S. (2001) Abortive base excision repair of radiation-induced clustered DNA

lesions. Proceedings of the National Academy of Sciences USA 98:7426-7430. PMCID: PMC34685

Blaisdell, J. O., Harrison, L., and Wallace, S. S. (2001) Base excision repair processing of radiation-induced

clustered DNA lesions. Radiation Protection Dosimetry, 97: 25-31.

Buchko, G.W., Wallace, S.S., and Kennedy, M.A. (2002) Base excision repair: NMR backbone

assignments of Escherichia coli formamidopyrimidine-DNA glycosylase. Journal of Biomolecular NMR,

22: 301-302.

Bandaru, V., Sunkara, S., Wallace, S.S., and Bond, J.P. (2002) A novel human DNA glycosylase that

removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII. DNA Repair,

1: 517-529.

Wallace, S. S. (2002) Biological consequences of free radical-damaged DNA bases. Free Radical Biology

and Medicine. 33: 1-14.

Fischhaber, P.L., Gerlach, V.L., Feaver, W.J., Hatahet, Z., Wallace, S.S., and Friedberg, E.C. (2002)

Human DNA polymerase bypasses thymine glycols during translesion synthesis in vitro and preferentially

incorporates adenine. Journal of Biological Chemistry 277:37604-37611.

Harper, M.E., Antoniou, A., Villalobos-Menuey, E., Russo, A., Trauger, R., Vendemelio, M., George, A.,

Bartholomew, R., Carlo, D., Shaikh, A., Kupperman, J., Newell, E.W., Bespalov, I.A., Wallace, S.S., Liu,

Y., Rogers, J.R., Gibbs, G.L., Leahy, J.L., Camley, R.E., Melamede, R., Newell, M.K. (2002)

Characterization of a novel metabolic strategy used by drug-resistant tumor cells. FASEB Journal 16:1550-

1557.

Wallace, S.S., Bandaru, V., Kathe, S., Bond, J.P. (2003) The enigma of endonuclease VIII. DNA Repair

2:441-453.

Shen, G.-P., Galick, H., Inoue, M. and Wallace, S.S. (2003) Decline of nuclear and mitochondrial oxidative

base excision repair activity in late passage human diploid fibroblasts. DNA Repair 2:673-693.

Kathe, S.D., Shen, G.-P., and Wallace, S.S. (2004) Single-strand breaks in DNA but not oxidative DNA

base damages block transcriptional elongation by RNA polymerase II in HeLa cell nuclear extracts. Journal

of Biological Chemistry 279:18511-18520.

Inoue, M., Shen, G.-P., Chaudhry, M.A., Galick, H., Blaisdell, J.O. and Wallace, S.S. (2004) Expression of

the oxidative base excision repair enzymes is not induced in TK6 human lymphoblastoid cells after low

doses of ionizing radiation. Radiation Research 161(4):409-417.

Bandaru, V., Cooper, W., Wallace, S.S. and Doublié, S. (2004) Overproduction, crystallization, and

preliminary crystallographic analysis of a novel human DNA repair enzyme that recognizes oxidative DNA

damage. Acta crystallographica. Section D, Biological crystallography 60:1142-1144.

Hogg, M., Wallace, S.S., and Doublié, S. (2004) Crystalographic snapshots of a replicative DNA


18

polymerase encountering an abasic site. EMBO J. 23:1483-1493. PMCID: PMC391061

Doublié, S., Bandaru, V., Bond, J.P., and Wallace, S.S. (2004) The crystal structure of human

endonuclease VIII-like 1 (NEIL1) reveals a zincless finger motif required for glycosylase activity.

Proceedings of the National Academy of Sciences USA 101(28):10284-10289. PMCID: PMC478564

(selected by Faculty of 1000)

Yang, N., Galick, H., and Wallace, S.S. (2004) Attempted base excision repair of ionizing radiation damage

in human lymphoblastoid cells produces lethal and mutagenic double strand breaks. DNA Repair

3(10):1323-1334. (Top 10 most cited papers in DNA Repair)

Buchko, G.W., McAteer, K., Wallace, S.S., and Kennedy, M.A. (2005) Solution-state NMR investigation

of DNA binding interactions in Escherichia coli formamidopyrimidine-DNA glycosylase (Fpg): a dynamic

description of the DNA/protein interface. DNA Repair 4(3):327-339.

Hogg, M., Wallace, S.S., Doublié, S. (2005) Bumps in the road: how replicative DNA polymerases see

DNA damage. Current Opinion in Structural Biology 15(1):86-93.

Nakae, Y., Stoward, P.J., Bespalov, I.A., Melamede, R.J., and Wallace, S.S. (2005) A new technique for

the quantitative assessment of 8-oxoguanine in nuclear DNA as a marker of oxidative stress. Application

to dystrophin-deficient DMD skeletal muscles. Histochemistry and Cell Biology 124(3-4):335-345.

Watanabe, T., Blasidell, J.O., Wallace, S.S., and Bond, J.P. (2005) Engineering functional changes in

Escherichia coli endonuclease III based on phylogenetic and structural analysis. Journal of Biological

Chemistry 280(40):34378-34384.

Yang, N., Chaudhry, M.A., and Wallace, S.S. (2006) Base excision repair by hNTH1 and hOGG1: A two

edged sword in the processing of DNA damage in -irradiated human cells. DNA Repair. 5(1):43-51.

Hogg, M., Cooper, W., Reha-Krantz, L., and Wallace, S.S. (2006) Kinetics of error generation in

homologous B-family DNA polymerases. Nucleic Acids Research 34(9):2528-2535. PMCID:

PMC1459414

Bandaru, V., Blaisdell, J.O., and Wallace, S.S. (2006) Oxidative DNA glycosylases: Recipes from cloning

to characterization. Methods in Enzymology. 408A:15-33.

Hogg, M., Aller, P., Konigsberg, W., Wallace, S.S. and Doublié, S. (2007) Structural and biochemical

investigation of the role in proofreading of a beta hairpin loop found in the exonuclease domain of a

replicative DNA polymerase of the B family. Journal of Biological Chemistry 282:1432-1444.

Aller, P., Rould, M.A., Hogg, M., Wallace, S.S. and Doublié, S. (2007) A structural rationale for stalling

of a replicative DNA polymerase at the most common oxidative thymine lesion, thymine glycol.

Proceedings of the National Academy of Sciences USA 104:814-818. PMCID: PMC1783396 (selected by

Faculty of 1000)

Blaisdell, J. and Wallace, S.S. (2007) Rapid determination of the active fraction of DNA repair

glycosylases: A novel fluorescence assay for trapped intermediates. Nucleic Acids Research 35(5):1601-

1611. PMCID: PMC1865064

Bandaru, V., Zhao, X., Newton, M.R., Burrows, C.J., Wallace, S.S. (2007) Human endonuclease VIII-like

(NEIL) proteins in the giant DNA Mimivirus. DNA Repair 6:1629-1641. PMCID: PMC2096709

Zhang, W., Bouffard, G.G., Wallace, S.S., NISC Comparative Sequencing Program, and Bond, J.P. (2007)

Estimation of DNA sequence context-dependent mutation rates using primate genomic sequences. Journal

of Molecular Evolution 65(3):207-14.

Zahn, K., Belrhali, H., Wallace, S.S. and Doublié, S. (2007) Caught bending the A-rule: crystal structures


19

of translesion DNA synthesis with a non natural nucleotide. Biochemistry. 46:10551-10561.

Prasad, A., Wallace, S.S. and Pederson, D.S. (2007) Initiation of base excision repair of oxidative lesions

in nucleosomes by the human, bifunctional glycosylase NTH1. Molecular and Cellular Biology 24:8442-

8453. PMCID: PMC2169407

Robey-Bond, S.M., Barrantes-Reynolds, R., Bond, J.P., Wallace, S.S. and Bandaru, V. (2008) Clostridium

acetobutylicum 8-oxoguanine DNA glycosylase (Ogg) differs from eukaryotic Oggs with respect to

opposite base discrimination. Biochemistry. 47(29):7626-36. PMCID: PMC2574669

Guo, Y., Wallace, S.S. and Bandaru, V. (2009) A Novel bicistronic vectors for overexpressing

Mycobacterium tuberculosis proteins in Escherichia coli. Protein Expression and Purification 65(2):230-

237. PMCID: PMC2747733

Faucher, F., Robey-Bond, S.M., Wallace, S.S. and Doublié, S. (2009) Structural characterization of

Clostridium acetobutylicum 8-oxoguanine DNA glycosylase in its apo-form and in complex with 8-

oxoguanosine. Journal of Molecular Biology 387(3):669-679. PMCID: PMC2678946

Kathe, S.D., Barrantes-Reynolds, R., Bandaru, V., Bond, J.P. and Wallace, S.S. (2009) Plant and fungal

Fpg homologs are formamidopyrimidine DNA glycosylases but not 8-oxoguanine DNA glycosylases. DNA

Repair 8(5):643-53. PMCID: PMC2730897

Faucher, F., Duclos, S., Bandaru, V., Wallace, S.S. and Doublié, S. (2009) Crystal structures of two archaeal

8-oxoguanine DNA glycosylases of the Ogg2 family provide structural insight into guanine/8-oxoguanine

distinction. Structure 17(5):703-12. PMCID: PMC2758660

Imamura, K., Wallace, S.S., and Doublié, S. (2009) Structural characterization of a viral NEIL1 ortholog

unliganded and bound to abasic site-containing DNA. Journal of Biological Chemistry 284(38):26174-83.

PMCID: 2758016

Faucher, F., Wallace, S.S. and Doublié, S. (2009) Structural basis for the lack of opposite base specificity

by the Clostridium acetobutylicum 8-oxoguanine DNA glycosylase. DNA Repair 8(11):1283-9. PMCID:

PMC2779579

Guo, Y., Bandaru, V., Jaruga, P., Zhao, X., Burrows, C.J., Iwai, S., Dizdaroglu, M., Bond, J.P. and Wallace,

S.S. (2009) The oxidative DNA glycosylases of Mycobacterium tuberculosis exhibit different substrate

preferences from their Escherichia coli counterparts. DNA Repair 9(2):177-190. PMCID: PMC2836239

Pumo, D.E., Barrantes-Reynolds, R., Kathe, S., Wallace, S.S., and Bond, J.P. (2010) Evolution of the

Fpg/Nei family of DNA glycosylases in: I. Kovalchuk and O. Kovalchuk (Eds.), Genome Instability and

Transgenerational Effects, Nova Science Publishers, Inc., New York, pp. 71-88.

Odell, I.D., Newick, K., Heintz, N., Wallace, S.S. and Pederson, D.S. (2010) Non-specific DNA binding

interferes with the efficient excision of oxidative lesions from chromatin by the human DNA glycosylase,

NEIL1. DNA Repair. 9(2):134-43. PMCID: PMC2829949

Faucher, F., Wallace, S.S. and Doublié, S. (2010) The C-terminal lysine of Ogg2 DNA glycosylases is a

major molecular determinant for guanine/8-oxoguanine distinction. Journal of Molecular Biology.

397(1):46-56. PMCID: PMC3085930

Liu, M., Bandaru, V., Bond, J.P., Jaruga, P., Zhao, X., Christov, P.O., Burrows, C.J, Rizzo, C.J.,

Dizdaroglu, M., and Wallace, S.S. (2010) The mouse ortholog of NEIL3 if a functional DNA glycosylase

in vitro and in vivo. Proceedings National Academy of Sciences USA. 107(11):4925-30. PMCID:

PMC2841873


20

Hogg, M., Rudnicki, J., Midkiff, J., Reha-Krantz, L., Doublié, S. and Wallace, S.S. (2010) The kinetics of

mismatch formation opposite lesions by the replicative DNA polymerase from bacteriophage RB69.

Biochemistry. 49(11):2317-25. PMCID: PMC2849760

Aller, P., Ye, Y., Wallace, S.S., Burrows, C. and Doublié, S. (2010) Crystal structure of a replicative DNA

polymerase bound to the oxidized guanine lesion guanidinohydantoin. Biochemistry, 49(11):2502-9.

PMCID: PMC2840191

Nemec, A.A., Wallace, S.S. and Sweasy, J.B. (2010) Variant base excision repair proteins: Contributors to

genomic instability. Seminars in Cancer Biology. 20(5):320-8. PMCID: PMC3254599.

Hogg, M., Seki, M., Wood, R.D., Doublié, S. and Wallace, S.S. (2011) Lesion bypass activity of DNA

polymerase (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts.

Journal of Molecular Biology. 405(3):642-52. PMCID: PMC3025778.

Zhan, K.E., Wallace, S.S. and Doublié, S. (2011) DNA polymerases provide a canon of strategies for

translesion synthesis past oxidatively generated lesions. Current Opinion in Structural Biology. 21(3):358-

69. PMCID: PMC3112272

Dunn, A.R., Kad, N.M., Nelson, S.R., Warshaw, D.M. and Wallace, S.S. (2011) Single Qdot-labeled

glycosylase molecules use a wedge amino acid to probe for lesions while scanning along DNA. Nucleic

Acids Research 39(17):7487-98. PMCID: PMC3177204

Aller, P.,Duclos,S., Wallace, S.S. and Doublié, S. (2011) A crystallographic study of the role of sequence

context on thymine glycol bypass by a replicative DNA polymerase serendipitously sheds light on the

exonuclease complex. Journal of Molecular Biology. 412(1):22-34. PMCID: PMC3167065

Barrantes-Reynolds, R., Wallace, S.S. and Bond, J.P. (2011) Use of shifts in amino acid frequency and

substitution rate to identify latent structural characters in base-excision repair enzymes. PloS One.

6(10):e25246. PMCID: PMC3188539

Odell, I.D., Barbour, J.-E., Murphy, D., Della Maria, J.A., Sweasy, J.B., Tomkinson, A.E., Wallace, S.S.

and Pederson, D.S. (2011) Nucleosome Disruption by DNA Ligase III-XRCC1 Promotes Efficient Base

Excision Repair. Molecular and Cellular Biology. 31(22):4623-32. PMCID: PMC3209256

Zahn, K.E., Wallace, S.S., Doublié, S. (2011) The miscoding potential of 5-hydroxy-cytosine arises due to

template instability in the replicative polymerase active site. Biochemistry. 29;50(47):10350-8. PMCID:

PMC3280588

Imamura, K., Averill, A., Wallace, S.S. and Doublié, S. (2011) Structural characterization of a viral

ortholog of the human DNA glycosylase NEIL1 bound to thymine glycol or 5-hydroxyuracil-containing

DNA. Journal of Biological Chemistry. 287(6):4288-98. PMCID: PMC3281731

Duclos, S., Doublié, S. and Wallace, S.S. (2012) “Consequences and repair of oxidative DNA damage,” in

The Cellular Response to the Genotoxic Insult: The Question of Threshold for Genotoxic Carcinogens. (H.

Greim and R. J. Albertini, Eds.)The Royal Society of Chemistry, Cambridge, United Kingdom, pp. 115-

159.

Prakash, A., Doublié, S. and Wallace, S.S. (2012) The Fpg/Nei family of DNA glycosylases: Substrates,

structures and search for damage. Prog Mol Biol Transl Sci. 110:71-91. PMCID: PMC4101889

Liu, M., Bandaru, V., Holmes, A., Averill, A.M., Cannan, W. and Wallace, S. S. (2012) Expression and

purification of active mouse and human NEIL3 proteins. Protein Expression and Purification. 84(1):130-

9. PMCID: PMC3378769

Duclos, S., Aller, P., Jaruga,P., Didzaroglu, M., Wallace, S.S. and Doublié, S. (2012) Structural and

biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg

http://www.ncbi.nlm.nih.gov/pubmed/21930793




21

glycosylases do not excise 8-oxoguanine. DNA Repair (Amst). 11(9):714-25. PMCID: PMC3419285

Wallace, S.S., Murphy, D.L. and Sweasy, J.B. (2012) Base excision repair and cancer. Cancer Letters

327(1-2):73-89. PMCID: PMC3361536

Liu, M., Doublié, S. and Wallace, S.S. (2013) Neil3, the final frontier for the DNA glycosylases that

recognize oxidative damage. Mutation Research. 743-744:4-11. PMCID: PMC3657305

Odell, I.D., Wallace, S.S. and Pederson, D. (2013) Rules of engagement for base excision repair in

chromatin. Journal of Cell Physiology 228(2): 258-266. PMCID: PMC3468691

Liu, M., Imamura, K., Averill, A.M., Wallace, S.S. and Doublié, S. (2013) Structural characterization of a

mouse ortholog of human NEIL3 with a marked preference for single-stranded DNA. Structure.

21(2):247-56. PMCID: PMC3856655

Wallace, S.S. (2013) Personal reflections of a woman scientist growing up in a man’s world. DNA Repair.

21(2):247-256.

Zhou, J., Liu, M., Fleming, A.M., Burrows, C.J. and Wallace S.S. (2013) Neil3 and NEIL1 DNA

glycosylases remove oxidative damages from quadruplex DNA and exhibit preferences for lesions in the

telomeric sequence context. Journal of Biological Chemistry. 288(38):27263-72. PMCID: PMC3779722

Galick, H. Kathe, S., Liu, M., Robey-Bond, S., Kidane, D., Wallace, S.S. and Sweasy, J.B. (2013) A

germline variant of human NTH1 DNA glycosylase induces genomic instability and cellular

transformation. Proceedings of the National Academy of Sciences USA. 110(35):14314-9. PMCID:

PMC3761600

Wallace, S.S. (2013) DNA glycosylases search for and remove oxidized DNA bases. Environmental and

Molecular Mutagenesis. 54(9):691-704. PMCID: PMC3997179

Prakash, A., Eckenroth, B.E., Averill, A.M., Imamura, K., Wallace, S.S. and Doublié, S. (2013) Structural

investigation of a viral ortholog of human NEIL2/3 DNA glycosylases. DNA Repair. 12(12):1062-71.

PMCID: PMC3856876

Maher, R.L., Prasad, A. Rizvanova, O., Wallace, S.S. and Pederson, D.S. (2013) Contribution of DNA

unwrapping from histone octamers to the repair of oxidatively damaged DNA in nucleosomes. (2013) DNA

Repair. 12(11):964-71. PMCID: PMC3877670

Prakash, A., Carroll, B., Sweasy, J.B., Wallace, S.S. and Doublié, S. (2014) Genome and cancer single

nucleotide polymorphisms of the human NEIL1 DNA glycosylase: activity, structure, and the effect of

editing. DNA Repair. 14:17-26. PMCID: PMC3926126

Nelson, S.R., Dunn, A.R., Kathe, S.D., Warshaw, D.M. and Wallace, S.S. (2014) Two glycosylase families

diffusively scan DNA using a wedge residue to probe for and identify oxidatively damaged bases.

Proceedings of the National Academy of Sciences. 111(20):E2091-9. PMCID: PMC4034194

Wallace, S.S. (2014) Base excision repair: A critical player in many games. DNA Repair. 19:14-26.

PMCID: PMC4100245

Lee, A.J., Warshaw, D.M. and Wallace, S.S. (2014) Insights into the glycosylase search for damage from

single molecule fluorescence microscopy. DNA Repair.20:23-31 PMCID: PMC4112009

Cannan, W.J., Tsang, B.P., Wallace, S.S. and Pederson, D.S. (2014) Nucleosomes suppress the formation

of double-strand DNA Breaks during attempted base excision repair of clustered oxidative damages.

Journal of Biological Chemistry. 289(29):19881-93. PMCID: PMC4106309

Zhou, J., Fleming, A.M., Averill, A.M., Burrows, C.J. and Wallace, S.S. (2015) The NEIL glycosylases

remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures. Nucleic Acids


http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997179/?tool=nihms

http://www.ncbi.nlm.nih.gov/pubmed?term=Cannan%20WJ%5BAuthor%5D&cauthor=true&cauthor_uid=24891506

http://www.ncbi.nlm.nih.gov/pubmed?term=Tsang%20BP%5BAuthor%5D&cauthor=true&cauthor_uid=24891506

http://www.ncbi.nlm.nih.gov/pubmed?term=Wallace%20SS%5BAuthor%5D&cauthor=true&cauthor_uid=24891506

http://www.ncbi.nlm.nih.gov/pubmed?term=Pederson%20DS%5BAuthor%5D&cauthor=true&cauthor_uid=24891506


22

Research. 43(8):4039-4054. PMCID: PMC4417164

Fleming, A.M., Zhou, J., Wallace, S.S. and Burrows, C.J. (2015) A role for the fifth G track in

G-quadruplex forming oncogene 2 promoter sequences during oxidative stress: Do these “spare tires” have

an evolved function? American Chemical Society Journal. In press.

Lee, A.J., Hilzinger, T.S., Nelson, S.R., Warshaw, D.M. and Wallace, S.S. (2014) The MUTYH colon

cancer-predisposing variant, Y165C, has a mutation in the wedge residue responsible for the DNA damage

search. In preparation.

Chan J., Zhou, J. Clayton, J.E., Lambelé, M., Wallace, S.S., and Thali, M. DNA glycosylase NEIL3 protects

telomere integrity during G2 to prevent chromosomal instability at mitosis. Submitted.

Zhou, J. Chan J., Clayton, J.E., Lambelé, M., Opresko, P., Thali, M. and Wallace S.S. The intrinsically

disordered C-terminal domain of NEIL3 secures chromosome segregation at mitosis by coupling long patch

BER at telomeres with activation of the ATM-mediated G2/M checkpoint. Submitted.

Massaad, M.J.*, Zhou, J.*, Tsuchimoto, D.*, Chou, J., Ohsumi, T., Jabara, H., Kane, J., Schmitz, K.,

Kyriacos, M., Torisu, K., Nakabeppu, Y., Kang, P., Choueiry, E., Megarbane, A., Mizui, M., Tsokos, G.,

El-Herz, W., Notarangelo, L., Wallace, S.S., Geha, R.S. The human Nei endonuclease VIII-like 3 (NEIL3)

is a novel gene associated with the development of auto-antibodies. Manuscript in preparation.

Lee, A.J., Warshaw, D.M. and Wallace, S.S. (2014) Visualizing the interaction between human DNA

glycosylase OGG1 and a site-specific 8-oxoguanine in plasmid DNA using single molecule approaches. In

preparation.

Robey-Bond, S.M., Benson, M.A., Barrantes-Reynolds, R., Bond, J.P. and Wallace, S.S. (2014)

Comparative single-turnover kinetics and Escherichia coli endonuclease III (hNTH1): Effects of single

point mutations on glycosylase activity. In preparation.

RECENT INVITED TALKS

August 1990 Invited Speaker, 15th International Cancer Congress, Hamburg

October 1990 Harvard Medical School, Department of Radiation Medicine

January 1991 Invited Speaker, General Motors Cancer Research Symposium:

"Oncogenic Mechanisms in Radiation-Induced Cancer", Fort Collins,

Colorado.

February 1991 Dartmouth Medical School, Department of Pharmacology and Toxicology

August 1991 Invited Speaker, International Congress of Radiation Research, Toronto

September 1991 W. Alton Jones Cell Science Center, Lake Placid, New York.

November 1991 Symposium Speaker, American Society for Therapeutic Radiology and Oncology

February 1992 Universite de Montreal, Department of Biochemistry

February 1992 University of Pittsburgh, Department of Environmental and Occupational Health

March 1992 Invited Speaker, Radiation Research Society, Salt Lake City, Utah.

April 1992 Invited Speaker, International Symposium: "The Structure, Biology and Pharmacology

of Abasic and Related DNA Sites", Paris, France.

April 1992 Invited Speaker, International Symposium: "Defined Damages in DNA and their

Biological Consequences", Bavaria

October 1992 Universite de Sherbrooke, Department of Nuclear Medicine and Radiobiology

November 1992 Michigan State, Cancer Center

December 1992 University of Illinois, Department of Physiology and Biophysics


23

February 1993 Invited Speaker, Keystone Symposium: "Nucleases: Structure, Function and

Biological Roles", Tamarron, Colorado.

March 1993 Invited Speaker, Radiation Research Society, Dallas, Texas.

April 1993 Plenary Lecturer, Environmental Mutagen Society, Norfolk, Virginia.

March 1993 University of North Carolina, Lineberger Comprehensive Cancer Center

April 1993 Memorial Sloan Kettering Cancer Center Symposium: "The Contribution of Physics

to Medicine", New York, New York.

May 1993 Johnson State College, Environmental and Health Sciences

June 1993 New Jersey Medical School, Department of Microbiology and Molecular Genetics

June 1993 Symposium Speaker, "Structural Biology: State of the Art 1993", Eighth Conversation:

Biomolecular Stereodynamics, Albany, New York.

September 1993 Lehman College, City University of New York, Department of Biological Sciences.

February 1994 Invited Speaker, Gordon Oxygen Radical Conference, Ventura, California

March 1994 University of Texas Medical Branch, Galveston, Texas.

July 1994 Invited Speaker, Gordon Mutagenesis Conference, Plymouth, New Hampshire

September 1994 Symposium Speaker, International Congress of Biochemistry, New Dehli

October 1994 Symposium Speaker, Workshop on Radiation Damage in DNA: Structure/Function

Relationships at Early Times, Gleneden, Oregon

May 1995 University of Massachusetts, College of Medicine, Worcester

June 1995 Invited Speaker, Gordon Toxicology Conference, Colby-Sawyer College, New

Hampshire

September 1995 Symposium Speaker, 10th International Conference on Radiation Research, Würzburg,

Germany.

September 1995 Symposium Speaker, Mechanisms of DNA Repair, Giens, France

October 1995 Parker Memorial Lecturer, Pacific Northwest Laboratories, Richland, WA

November 1995 Tolmach Memorial Lecturer, Washington University, St. Louis, MO

December 1995 Department of Pharmacology, SUNY Stony Brook

February 1995 Department of Biophysics, University of Rochester

April 1996 Invited Speaker, Banbury Conference: DNA Base “Flipping”: How and Why

April 1996 Workshop Co-Chair, Radiation Research Society

June 1996 Symposium Speaker, ASBMB Satellite Meeting on DNA Repair

February 1997 Invited Speaker, Gordon DNA Mammalian Repair Conference, Ventura, California

February 1997 Invited Speaker, Stanford University, Palo Alto, CA

February 1997 Symposium Speaker, 7th Fisher Winternational Symposium, Quebec

April 1997 Symposium Speaker, AACR

May 1997 Keynote Speaker, Sealy Center for Molecular Science, University of Texas Medical

Branch

October 1997 Invited Speaker, NATO Conference on DNA Damage and Repair, Turkey

March 1998 American Health Foundation, New York

April 1998 Symposium Speaker, Radiation Research Society, Louisville, Kentucky

August 1998 Symposium Speaker, American Chemical Society, DNA Damage and Repair, Boston

November 1998 Symposium Speaker, American Association for Cancer Research, Sanibel Island,

Florida, DNA Repair

February 1999 Invited Speaker, Gordon DNA Mammalian Repair Conference, Ventura, California

February 1999 Invited Speaker, Gordon Radiation Oncology Conference, Ventura, California

March 1999 Speaker VT Cancer Center 15th Regional Research Symposium, Burlington, VT

April 1999 Symposium Speaker, Radiation Damage to DNA, UNC, Chapel Hill, NC

July 1999 Symposium Speaker, 11th International Congress of Radiation Research, Dublin,

Ireland


24

November 1999 Co-chair and Symposium Speaker, International Conference on DNA Repair and

Mutagenesis: Mechanism, Control and Biological Consequences, Hilton Head,

South Carolina

March 2000 Invited Speaker, Molecular Biology of Oxidative Stress, Banbury Center, Cold Spring

Harbor, NY

April 2000 Department of Microbiology and Immunology, University of South Alabama

August 2000 Invited Speaker, Gordon Conference on Mutagenesis, Oxford, United Kingdom

January 2001 Invited Speaker, Gordon Mammalian DNA Repair Conference, Ventura, California

February 2001 Symposium Speaker, National Council on Radiation Protection Symposium,

Arlington, Virginia

April 2001 Symposium Speaker, Radiation Research Society, Puerto Rico

September 2001 Invited Speaker, VIIth International Workshop Radiation Damage to DNA Orléans,

France

March 2002 Invited Speaker, Low Dose Workshop, Rockville, Maryland

April 2002 Symposium Speaker, Radiation Research Society, Reno, Nevada

July 2002 Invited Speaker, Gordon Conference on Mutagenesis, Lewiston, Maine

October 2002 Invited Speaker First US/Japan Conference on DNA Repair, Japan

October 2002 Invited Speaker, Lawrence Berkeley National Laboratory, Berkeley, California

January 2003 Invited Speaker, Department of Biochemistry and Molecular Biology, Georgetown

University, Washington, D.C.

February 2003 Invited Speaker, Department of Biological Sciences, Division of Molecular and

Computational Biology, University of Southern California, Los Angeles,

California

May 2003 Invited Speaker, Blaffer Seminar, MD Anderson Cancer Center, Houston, Texas

May 2003 Invited Speaker, International Workshop on Biological Basis of Sensitivity to Ionizing

Radiation, Heidelberg, Germany

May 2003 Invited Speaker, University of Texas, San Antonio

August 2003 Symposium Speaker, 12th International Congress of Radiation Research, Brisbane,

Australia

October 2003 Invited Speaker, First EU-US DNA Repair Meeting on Endogenous Stress, National

Conference Center,Virginia

February 2004 Symposium Speaker, American Association for Cancer Research, Dana Point,

California

April 2004 Invited Speaker, MIT, Cambridge, Massachusetts

May 2004 Symposium Speaker, 8th International Workshop on Radiation Damage to DNA, Banff,

Alberta, Canada

June 2004 Invited Speaker Second US/Japan Conference on DNA Repair, Hawaii

November 2004 Symposium Speaker, DNA Repair and Mutagenesis, Southhampton, Bermuda

October 2005 Keynote Address, John B. Little Symposium, Boston

December 2005 Invited Speaker, Second EU-US DNA Repair Meeting on Endogenous Stress, Base

Excision Repair and Related Processes, Erice, Sicily

March 2006 Invited Speaker, Yale, New Haven, Connecticut

May 2006 Keynote Address, 9th International Workshop on Radiation Damage to DNA, Turkey

November 2006 Invited Speaker, University of Massachusetts Medical School

May 2007 Invited Speaker, Third US/Japan Conference on DNA Repair, Sendai, Japan

June 2007 Invited Speaker, Gordon Conference on Nucleic Acids

July 2007 Chairperson and Symposium Speaker, 13th International Congress of Radiation

Research, San Francisco, California

October 2007 Invited Speaker, Environmental Mutagenesis Society, Atlanta, Georgia

June 2008 Invited Speaker, 10th International Workshop on Radiation Damage to DNA, Japan


25

February 2009 Invited Speaker, US-EU Repair of Endogenous Genome Damage, Galveston, Texas

March 2009 Invited Speaker, Portland State University, Portland, Oregon

May 2009 Keynote Address, International Conference on DNA Repair and Mutagenesis,

Whistler, British Columbia

August 2009 Invited Speaker, Gordon Research Conference: Genetic Toxicology, Vermont

October 2009 Invited Speaker, Environmental Mutagen Society Meeting, St. Louis

March 2010 Invited Speaker, Gordon Research Conference on DNA Damage, Mutation and

Cancer, Ventura, California

May 2010 Invited Speaker, 11th International Workshop on Radiation Damage to DNA, Atlanta,

Georgia

June 2010 Invited Speaker and Session Chair, 2010 FASEB Nucleic Acids Enzymes Meeting,

Saxton’s River, Vermont

October 2010 Invited Speaker, Environmental Mutagen Society Meeting, Fort Worth, Texas

February 2011 Keynote Address, FEBS Genome Instability and DNA Repair Conference, Armenia

May 2011 Invited Speaker, 4th US-EU Conference on Base Damage and Repair, Oslo, Norway

May 2011 Invited Speaker, Department of Medical Biochemistry and Biophysics, Umea

University, Sweden

July 2011 Invited Speaker, Department of Chemistry and Chemical Biology, Northeastern

University, Boston

August 2011 Keynote Lecturer to Scholars in Training Symposium Honoring Women in Radiation

Research, International Congress of Radiation Research, Warsaw

December 2011 Invited Speaker, Boston Children’s Hospital, Division of Immunology, Harvard

Medical School

June 2012 Invited Speaker, 12th International Workshop on Radiation Damage to DNA, Prague,

Czech Republic

June 2012 Invited Speaker, 3rd Erling Seeberg Symposium, Trondheim, Norway

September 2012 Plenary Lecturer, 43rd Annual Meeting of the Environmental Mutagen Society,

Bellevue, Washington

March 2013 Invited Speaker, Laboratory of Molecular Gerontology, National Institute on Aging,

DNA Repair Video Conference

August 2013 Invited Speaker, Laboratory of Molecular Genetics, National Institute of

Environmental Health Sciences, Research Triangle Park, North Carolina

November 2013 Invited Speaker, International Conference on Environmental Mutagens, Foz Do

Iguacu, Brazil

December 2013 Invited Speaker, City College of New York, New York, New York

January 2014 Invited Speaker, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania

March 2014 Invited Speaker, Discussion Leader, Gordon Research Conference on DNA Damage,

Mutation and Cancer, Ventura, California

June 2014 Invited Speaker, 13th International Workshop on Radiation Damage to DNA, Boston,

Massachusetts

June 2014 Invited Lecturer, NASA Space Radiation Course, Brookhaven National Laboratory,

New York

September 2014 Invited Symposium Speaker, 45th Annual Meeting of the Environmental Mutagen and

Genomics Society, Orlando, Florida

September 2014 Invited Symposium Speaker, 60th Annual Meeting of the Radiation Research Society,

Las Vegas, Nevada

May 2015 Invited Symposium Speaker, 15th International Congress of Radiation Research,

Kyoto, Japan

June 2015 Invited Lecturer, NASA Space Radiation Course, Brookhaven National Laboratory,

New York


26

August 2015 Invited Symposium Speaker, Genomic Integrity Conference, Cairns, Australia

August 2015 Invited Symposium Speaker, 250th American Chemical Society National Meeting,

Boston, Massachusetts

September 2015 Invited Speaker, 61st Annual Meeting of the Radiation Research Society, Weston,

Florida

CONTACT INFORMATION:


Distinguished University Professor and Chair

Department of Microbiology and Molecular Genetics

The Markey Center for Molecular Genetics

University of Vermont

95 Carrigan Drive, Stafford Hall

Burlington, Vermont 05405-0084

Phone: 802-656-2164

Fax: 802-656-8749

E-mail: [email protected]

susan s. wallace

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