Microbiology Lecture: Antimicrobial Therapy and Drug ResistanceSpring 2016

I. The Fundamentals of Antibiotic Therapy

a. Selective Toxicity

b. Limited Spectrum of Activity

c. Bacteriostatic or Bacteriocidal

II. Mechanisms of Actiona. Cell Wall Synthesis

The New Kid on the block – Teixobactin (January 2015)

b. Membrane Integrity

c. Metabolism i. Sulfa Drugs

d. DNA Synthesis and Integrity

i. Quinolones

ii. Metronidazole

e. Transcription Inhibitors

f. Translation Inhibitors

i. Drugs that affect the 30S subunit

ii. Drugs that affect the 50S subunit

III. Antibiotic Resistancea. Mechanisms

b. Multidrug Resistance

c. Development of Drug Resistancei. Overuse

ii. Improper Use

iii. Agricultural Use

d. Fighting Drug Resistance

i. Developing New Antibiotics1. Targeting Resistance Mechanisms

2. Development of New Antibiotic Classes

3. Using Genomics to Identify New Targets

ii. Blasts from the Past

iii. It Takes Two

iv. Strategies for Extending Antibiotic Lifetimes