sustainable industrial processes based on a c–c bond
TRANSCRIPT
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Horizon 2020Innovation Action: BIOTEC-3-2014
Widening Industrial Application of Enzymatic Processes
Sustainable industrial processesbased on a C–C bond-forming
enzyme platform
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Horizon 2020 BIOTECH-3-2014INNOVATION ACTION
CARBAZYMES GA 635595
Total Consortium Budget 9.2 M €
EU Maximum Grant Amount 8.2 M €
SME Funding (ca. 30%) 2.5 M €
Creation of New Jobs 14 ER, 6 ESR
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5 COUNTRIES
UK Spain Croatia Germany The Netherlands
6 SME´s 7 academic partners 1 large company
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CARBAZYMES at a Glance
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Carboligation is of central importance in industrialsynthesis to create relevant new molecules
Implementation of biocatalytic carboligationprocesses remains largely unexplored due to: long development timelines lack of broader biocatalytic reaction platforms
CarbaZymes targets the “Valley of Death”with industry-suited carboligation enzymes for biocatalytic synthesis of industrial products
APIs (e.g. anti-cholesterol/-diabetes; >28 Mrd/yr market) bulk chemicals (polymer precursors)
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CARBAZYMES Platform
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Aldolase 4-‐OT Th-‐DP
Transaminases
Scaff
old by
C-‐C coup
ling
Op=
onal
Mod
ifica=o
ns
Fine
che
micals/APIs
Oxidoreductases Dehydratases Chemical
Deoxysugars
Chiral building blocks
Specialty aminoacids
HHDH
Bulk che
micals
Hydroxy acids
Branchedacids
ω-‐Amino acidsCatalyst Too
lbox
Enzyme panels
Algorithms
Specific enzymes
BROAD RANGE CARBOLIGATION PLATFORM DEM
O/M
ARK
ET
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Company Types in CARBAZYMES
Adapted from Festel Capital 2010OECD workshop "Outlook on Industrial Biotechnology”
high
DedicatedStart-ups
DedicatedSMEs
DedicatedMNEs
DiversifiedSMEs
DiversifiedMNEs
DedicatedMNEs
DiversifiedSMEs
DiversifiedMNEs
DedicatedSMEs
DedicatedStart-ups
Technology developmentCompany sizeC
omm
erci
al d
evel
opm
ent
Impo
rtan
ce o
f bio
tech
nolo
gy
low low
high
low highsmall large
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Bridging the Gap between Lab and Industrial Scale
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15%15%
23%23%
36%36%
10%10%25% of overall PMs forbioprocess development,scale-up & demonstration
Work Packages & Schedule
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*Allowable cost contribution of : 0.01 €/kg
0.1€/kg
100€/kg
10 €/kg
1 €/kg
*Organic Process Research & Development 2011, 15, 266–274
The economic challenge
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CARBAZYMES products, procedures and servicesare expected to be commercialized in differentbusiness segments
Innovation, Exploitation, Impact
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Dissemination
General public
Academic community
Industry
Promoting societal awareness: Biocatalysis and biotechnology
as a sustainable tool for industrial syntheses
Help to bring CARBAZYMES products to market
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12!