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www.sib.swiss Sustaining open data resources in bioinformatics: the UniProt case study Dr. Chiara Gabella, SIB Project Manager

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Page 1: Sustaining open data resources in bioinformatics: the ... · PDF fileresources in bioinformatics: the UniProt case study ... 7. Freemium service 8. Razor & blades 9. ... 7% annual

www.sib.swiss

Sustaining open dataresources in bioinformatics:the UniProt case studyDr. Chiara Gabella, SIB Project Manager

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SIB Swiss Institute of Bioinformatics

19 partnerinstitutions

65 groups800 members

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Bioinformatics competence centers

DBMUniversity

Hospital Basel

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Resources for the international community

More than 150 bioinformatics

resources

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Resources for the international community

www.expasy.org

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Knowledgebases

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Expert manualcuration

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UniProt

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Resources for the international community

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Resources for the international community

UniProtKB/Swiss-ProtEncyclopedia of protein sequencesand functional information

50 biocurators

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Resources for the international community

UniProtKB/Swiss-ProtEncyclopedia of protein sequencesand functional information

>550,000 manually curated protein

sequences

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Resources for the international community

UniProtKB/Swiss-ProtEncyclopedia of protein sequencesand functional information

220,000 curated literature references

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Resources for the international community

UniProtKB/Swiss-ProtEncyclopedia of protein sequencesand functional information

~500,000 usersper month

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Access toUniProt is

free

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Cost ofUniProt is

freeNOT

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Cost of UniProt ≈ 0.1% of the

reviewed research

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First Swiss-Prot entry:

P00001Amos Bairoch

duringhis PhD thesis

1986 1996

How is UniProt funded?

SNSF

Internet storm of protest

Cyber-earthquake2500 emails

Funding crisisSwiss-Prot bound

to disappear

Interim funding SNFS

Creation of the SIB Swiss Institute of

Bioinformatics

1998 Institutional support SIB

+Commercial licence fees

NIHpublishes a call for resource

grant

2002

Formation of the UniProt consortium

Institutional support SIB

+Institutional

support EMBL-EBI

+Research NIH grant

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1. National funding

3. Institutional support

2. Infrastructure model

6. Subscription fees

11. Wiki model

10. Advertising

12. Philanthropy

7. Freemium service

8. Razor & blades

9. Consortium

5. Content licensing

Academic users/Taxpayer money

Charity, donations or third party

4. Research project grants

Commercial users

Possible funding models

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Subscription fees

1. National funding

3. Institutional support

2. Infrastructure model

6. Subscription fees

11. Wiki model

10. Advertising

12. Philanthropy

7. Freemium service

8. Razor & blades

9. Consortium

5. Content licensing

Academic users/Taxpayer money

Charity, donations or third party

4. Research project grants

Commercial users

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€ 3.5/ month

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€ 0.055/ MB download

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€ 0.055/ MB download

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Content licensing

1. National funding

3. Institutional support

2. Infrastructure model

6. Subscription fees

11. Wiki model

10. Advertising

12. Philanthropy

7. Freemium service

8. Razor & blades

9. Consortium

5. Content licensing

Academic users/Taxpayer money

Charity, donations or third party

4. Research project grants

Commercial users

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€ 2,500 - € 90,000for Swiss-Prot subscription in 1998

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€ 2,500 - € 90,000for Swiss-Prot subscription in 1998

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National model

1. National funding

3. Institutional support

2. Infrastructure model

6. Subscription fees

11. Wiki model

10. Advertising

12. Philanthropy

7. Freemium service

8. Razor & blades

9. Consortium

5. Content licensing

Academic users/Taxpayer money

Charity, donations or third party

4. Research project grants

Commercial users

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Proportional to usage

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0.00025 – 0.00035‰ GDP

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0.013‰R&D spending

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Advertising

1. National funding

3. Institutional support

2. Infrastructure model

6. Subscription fees

11. Wiki model

10. Advertising

12. Philanthropy

7. Freemium service

8. Razor & blades

9. Consortium

5. Content licensing

Academic users/Taxpayer money

Charity, donations or third party

4. Research project grants

Commercial users

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7% annual budget

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7% annual budget

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Philanthropy

1. National funding

3. Institutional support

2. Infrastructure model

6. Subscription fees

11. Wiki model

10. Advertising

12. Philanthropy

7. Freemium service

8. Razor & blades

9. Consortium

5. Content licensing

Academic users/Taxpayer money

Charity, donations or third party

4. Research project grants

Commercial users

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<5% annual budget

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<5% annual budget

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Infrastructure model

1. National funding

3. Institutional support

2. Infrastructure model

6. Subscription fees

11. Wiki model

10. Advertising

12. Philanthropy

7. Freemium service

8. Razor & blades

9. Consortium

5. Content licensing

Academic users/Taxpayer money

Charity, donations or third party

4. Research project grants

Commercial users

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5 funding agencies

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0.25 %total spending for life

science research grantscould sustain UniProt

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Scalable with the research

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International

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Open datais not free

data

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Long termsustainable model

is needed

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www.sib.swiss

Thank you