sustaining open data resources in bioinformatics: the ... · pdf fileresources in...
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www.sib.swiss
Sustaining open dataresources in bioinformatics:the UniProt case studyDr. Chiara Gabella, SIB Project Manager
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SIB Swiss Institute of Bioinformatics
19 partnerinstitutions
65 groups800 members
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Bioinformatics competence centers
DBMUniversity
Hospital Basel
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Resources for the international community
More than 150 bioinformatics
resources
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Resources for the international community
www.expasy.org
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Knowledgebases
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Expert manualcuration
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UniProt
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Resources for the international community
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Resources for the international community
UniProtKB/Swiss-ProtEncyclopedia of protein sequencesand functional information
50 biocurators
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Resources for the international community
UniProtKB/Swiss-ProtEncyclopedia of protein sequencesand functional information
>550,000 manually curated protein
sequences
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Resources for the international community
UniProtKB/Swiss-ProtEncyclopedia of protein sequencesand functional information
220,000 curated literature references
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Resources for the international community
UniProtKB/Swiss-ProtEncyclopedia of protein sequencesand functional information
~500,000 usersper month
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Access toUniProt is
free
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Cost ofUniProt is
freeNOT
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Cost of UniProt ≈ 0.1% of the
reviewed research
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First Swiss-Prot entry:
P00001Amos Bairoch
duringhis PhD thesis
1986 1996
How is UniProt funded?
SNSF
Internet storm of protest
Cyber-earthquake2500 emails
Funding crisisSwiss-Prot bound
to disappear
Interim funding SNFS
Creation of the SIB Swiss Institute of
Bioinformatics
1998 Institutional support SIB
+Commercial licence fees
NIHpublishes a call for resource
grant
2002
Formation of the UniProt consortium
Institutional support SIB
+Institutional
support EMBL-EBI
+Research NIH grant
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1. National funding
3. Institutional support
2. Infrastructure model
6. Subscription fees
11. Wiki model
10. Advertising
12. Philanthropy
7. Freemium service
8. Razor & blades
9. Consortium
5. Content licensing
Academic users/Taxpayer money
Charity, donations or third party
4. Research project grants
Commercial users
Possible funding models
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Subscription fees
1. National funding
3. Institutional support
2. Infrastructure model
6. Subscription fees
11. Wiki model
10. Advertising
12. Philanthropy
7. Freemium service
8. Razor & blades
9. Consortium
5. Content licensing
Academic users/Taxpayer money
Charity, donations or third party
4. Research project grants
Commercial users
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€ 3.5/ month
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€ 0.055/ MB download
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€ 0.055/ MB download
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Content licensing
1. National funding
3. Institutional support
2. Infrastructure model
6. Subscription fees
11. Wiki model
10. Advertising
12. Philanthropy
7. Freemium service
8. Razor & blades
9. Consortium
5. Content licensing
Academic users/Taxpayer money
Charity, donations or third party
4. Research project grants
Commercial users
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€ 2,500 - € 90,000for Swiss-Prot subscription in 1998
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€ 2,500 - € 90,000for Swiss-Prot subscription in 1998
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National model
1. National funding
3. Institutional support
2. Infrastructure model
6. Subscription fees
11. Wiki model
10. Advertising
12. Philanthropy
7. Freemium service
8. Razor & blades
9. Consortium
5. Content licensing
Academic users/Taxpayer money
Charity, donations or third party
4. Research project grants
Commercial users
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Proportional to usage
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0.00025 – 0.00035‰ GDP
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0.013‰R&D spending
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Advertising
1. National funding
3. Institutional support
2. Infrastructure model
6. Subscription fees
11. Wiki model
10. Advertising
12. Philanthropy
7. Freemium service
8. Razor & blades
9. Consortium
5. Content licensing
Academic users/Taxpayer money
Charity, donations or third party
4. Research project grants
Commercial users
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7% annual budget
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7% annual budget
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Philanthropy
1. National funding
3. Institutional support
2. Infrastructure model
6. Subscription fees
11. Wiki model
10. Advertising
12. Philanthropy
7. Freemium service
8. Razor & blades
9. Consortium
5. Content licensing
Academic users/Taxpayer money
Charity, donations or third party
4. Research project grants
Commercial users
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<5% annual budget
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<5% annual budget
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Infrastructure model
1. National funding
3. Institutional support
2. Infrastructure model
6. Subscription fees
11. Wiki model
10. Advertising
12. Philanthropy
7. Freemium service
8. Razor & blades
9. Consortium
5. Content licensing
Academic users/Taxpayer money
Charity, donations or third party
4. Research project grants
Commercial users
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5 funding agencies
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0.25 %total spending for life
science research grantscould sustain UniProt
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Scalable with the research
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International
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Open datais not free
data
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Long termsustainable model
is needed
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www.sib.swiss
Thank you