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Syllabus for B.Sc.(Honors) in Chemistry Department of Chemistry

Faculty of Science Mawlana Bhashani Science and Technology University

Santosh, Tangail-1902

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Course distribution and Marks: 1. The syllabus for the 4-year B.Sc. (Honors) in Chemistry degree consists of 160

credits and will be divided into eight semesters. Every two semester will cover an academic year. For each semester, the examinations will be held at the end of the semester. A candidate for the above mentioned degree have to take total 75 (seventy five) courses covering 160 credits. The summary of the syllabus is given below:

91 credits of Chemistry theory courses (Major) 30.5 Chemistry practical courses (Major) 3.5 credits oral course (Major) 6 credits (Internship at Industry or Research Organization/Project work) + Oral

(Major) 11 credits Mathematics theory courses (Integrated) 8 credits Physics theory courses (Integrated) 2 credits Physics practical courses (Integrated) 2 credits Biology theory course (Integrated) 2 credits Biochemistry theory course (Integrated) 2 credits Microbiology theory course (Integrated) 2 credits English theory course (Integrated) ________________________________________________________ Total = 160 credits

The CHEM-4207 (Internship at Industry or Research Organization/ Project work) + Oral course will be meant for giving practical training to the students in an appropriate chemical/pharmaceutical industry or doing short-term research work offered by the teachers of the department or in an appropriate research institution. The department will assure whether a candidate have to accomplish internship at Industry or Research Organization or project work according to the availability of the position.

2. Assignment of credits:

Theory Courses: A three (3) credit course will involve at least three classes of fifty minutes per week and at least four class tests. A two (2) credit course will involve at least two classes of fifty minutes per week and at least three class tests. Of the total marks, 70% marks will be from written examination to be held at the end of the semester and 20% marks from class tests conducted throughout the course and 10% marks from class attendance. Candidates having less than 60% attendance will not be allowed to sit for the examination. Practical Courses: A two (2) credit course will involve four classes of fifty minutes per week. Out of total marks, 70% marks will be allocated for continuous assessment,

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20% marks will be from one quiz test and 10% marks will be from viva voce. A one and half (1.5) credit course will involve three classes of fifty minutes per week. Out of total marks, 70% marks will be allocated for continuous assessment, 20% marks will be from one quiz test and 10% marks will be from viva voce. A one (1) credit course will involve two classes of fifty minutes per week and one quiz test of 20 marks, continuous assessment of 70 marks including a viva voce of 10 marks. The courses to be offered in the different semesters are detailed below:

1st Year 1st Semester

Course No. Title of the course Credits Hrs/Week CHEM-1101 Physical Chemistry-I 2.0 02 CHEM-1102 Physical Chemistry Practical-I 1.0 02 CHEM-1103 Inorganic Chemistry-I 2.0 02 CHEM-1104 Qualitative Inorganic Practical -I 1.5 03 CHEM-1105 Organic Chemistry-I 2.0 02 CHEM-1106 Calculus 3.0 03 CHEM-1107 Mechanics and Properties of Matter and

Waves 3.0 03

CHEM-1108 Physics Practical -I 1.0 02 CHEM-1109 Biology 2.0 02 CHEM-1110 Communicative English 2.0 02 CHEM-1111 Oral 0.5 -

20 1st Year 2nd Semester

Course No. Title of the course Credits Hrs/Week CHEM-1201 Physical Chemistry-II 3.0 03 CHEM-1202 Physical Chemistry Practical -II 1.5 03 CHEM-1203 Inorganic Chemistry II 2.0 02 CHEM-1204 Qualitative Inorganic Practical -II 2.0 04 CHEM-1205 Organic Chemistry-II 3.0 03 CHEM-1206 Organic Chemistry Practical -I 2.0 04 CHEM-1207 Analytical Geometry and Ordinary

Differential Equation 2.0 02

CHEM-1208 Electricity and Magnetism 3.0 03 CHEM-1209 Oral 0.5 -

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2nd Year 1st Semester

Course No. Title of the course Credits Hrs/Week CHEM-2101 Chemical Thermodynamics & Phase

Equilibrium 2.0 02

CHEM-2102 Physical Chemistry Practical-III 1.5 03 CHEM-2103 Chemistry of Element-I 2.0 02 CHEM-2104 Quantitative Inorganic Practical -I 2.0 04 CHEM-2105 Organic Chemistry-III 3.0 03 CHEM-2106 Preparative Organic Chemistry Practical 2.0 04 CHEM-2107 Computing and Information Technology in

Chemistry 2.0 02

CHEM-2108 Mathematical Methods 3.0 03 CHEM-2109 Electronics and Optics 2.0 02 CHEM-2110 Oral 0.5 -

20 2nd Year 2nd Semester

Course No. Title of the course Credits Hrs/Week CHEM-2201 Electrochemistry 2.0 02 CHEM-2202 Electro-analytical Practical 1.0 02 CHEM-2203 Chemistry of Element-II 2.0 02 CHEM-2204 Quantitative Inorganic Practical -II 1.5 03 CHEM-2205 Organic Chemistry-IV (Biomolecules) 3.0 03 CHEM-2206 Analytical Chemistry 3.0 03 CHEM-2207 Nuclear and Radiation Chemistry 3.0 03 CHEM-2208 Physics Practical-II 1.0 02 CHEM-2209 Statistics and Numerical Methods 3.0 03 CHEM-2210 Oral 0.5 -

20 3rd Year 1st Semester

Course No. Title of the course Credits Hrs/Week CHEM-3101 Chemical Kinetics 2.0 02 CHEM-3102 Physical Chemistry Practical-IV 1.5 03 CHEM-3103 Atomic Structure and Chemical Bonding

(Advanced Concept) 2.0 02

CHEM-3104 Chemical Spectroscopy 3.0 03 CHEM-3105 Identification of Organic Compounds (Practical) 2.0 04 CHEM-3106 Chemistry of Natural Products 2.0 02 CHEM-3107 Fundamentals of Pharmaceutical Chemistry 3.0 03 CHEM-3108 Pharmaceutical Chemistry Practical and Field

Visit 1.5 + 0.5 = 2.0

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CHEM-3109 Microbiology 2.0 02 CHEM-3110 Oral 0.5 -

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3rd Year 2nd Semester

Course No. Title of the course Credits Hrs/Week CHEM-3201 Transition Metals and Coordination

Chemistry 3.0 03

CHEM-3202 Inorganic Synthesis Practical 2.0 04 CHEM-3203 Organic Reaction Mechanism 3.0 03 CHEM-3204 Chromatographic Separation Practical 1.5 03 CHEM-3205 Stereochemistry 3.0 03 CHEM-3206 Industrial Chemistry 3.0 03 CHEM-3207 Industrial Chemistry Practical and Field Visit 1.5 + 0.5

= 2.0 03

CHEM-3208 Biochemistry 2.0 02 CHEM-3209 Oral 0.5 -

20 4th Year 1st Semester

Course No. Title of the course Credits Hrs/Week CHEM-4101 Applications of Spectroscopic Methods in

Chemical Analysis 3.0 03

CHEM-4102 Solid State Chemistry & Chemical Crystallography

3.0 03

CHEM-4103 Polymer Chemistry 3.0 03 CHEM-4104 Environmental Chemistry 3.0 03 CHEM-4105 Theoretical Organic Chemistry 3.0 03 CHEM-4106 Chemistry Research Methodology 2.0 02 CHEM-4107 Organo-applied Chemistry Practical 1.5 03 CHEM-4108 Medicinal Chemistry 2.0 02 CHEM-4109 Oral 0.5 -

21 4th Year 2nd Semester

Course No. Title of the course Credits Hrs/Week CHEM-4201 Quantum Chemistry and Statistical

Thermodynamics 3.0 03

CHEM-4202 Organometallic Chemistry 3.0 03 CHEM-4203 Green Chemistry 2.0 02 CHEM-4204 Organic Reagents and Syntheses 2.0 02 CHEM-4205 Bioinorganic Chemistry 2.0 02 CHEM-4206 Supramolecular Chemistry 2.0 02 CHEM-4207 (Internship at Industry or Research

Organization/ Project work) + Oral 5+1 = 6 12

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Course Code: CHEM 1101 Physical Chemistry I (Elements of Physical Chemistry-I)

(Full Marks: 20 + 10 + 70 = 100; 2 Credits)

1. Introduction: Matter, Potential and kinetic energy of molecules, Translational, rotational and vibrational energy of systems, Electromagnetic radiation, Equipartition of energy, Quantization of energy of particles, States of aggregation, Chemistry and measurements, Units of measurements and significant figures, Accuracy & Precision, Absolute error, Relative error.

2. The Gaseous State: The perfect and real gases, Gas laws, Combined gas law, Perfect

gas equation, Kinetic theory of gases: application to ideal gases, RMS velocity, Average velocity, Most probable velocity, molecular speeds (diffusion and effusion), Maxwell-Boltzmann distribution of speeds, Collision frequency, Mean free path, deviation from ideal behavior, compressibility factor, Amagat’s curve, condensation, van der Waal’s equation, critical constants, Principles of corresponding states,.

3. The Liquids: Change of state, Phase diagrams of water, carbon dioxide and sulfur,

Phase transition and its types: melting, freezing, vaporization, condensation, sublimation, deposition, vapor pressure, boiling point, melting point, Heat of phase transition, heat of fusion, heat of vaporization, Clausius-Clapeyron equation, Properties of liquids: surface tension and viscosity, Different forces (intermolecular, dipole-dipole, London, van der Waals), Hydrogen bonding, Structure and properties of water.

4. The Solids: Classification of solids on the basis of shapes and bonds, crystalline and

amorphous solids, crystal lattices and unit cell, crystal system, Properties of crystals; polymorphism, Isomorphism, crystal analysis (Bragg’s law), Cubic unit cell, Face and body centered cubic unit cell, Simple cubic unit cell, Crystal defect.

5. Solutions: Types of solutions, Different types of concentration expressions,

Solubility and solution process, Factors in explaining solubility, Molecular solutions and ionic solutions, Effects of temperature and pressure on solubility, Henry’s law: distribution of a solid between two immiscible liquids, Vapor pressure of ideal solutions; Vapor pressure of actual liquid pairs; Boiling point diagrams of miscible binary mixtures; Distillation of binary miscible solutions; Azeotropes, Theory of fractional distillation, Solubility of partially miscible liquid pairs, Vapor pressure and distillation of immiscible liquid, Solubility curve, Colligative properties, Vapor pressure of a solution, Raoult’s law of vapor pressure lowering, Boiling point elevation and freezing point depression, Osmosis and osmotic pressure, Ionic solutions, Properties of ionic solutions, Colligative properties of ionic solution.

Books Recommended:

1. D. Ebbing, General Chemistry, Houghton Mifflin Company, Boston, New York.

2. Raymond Chang, Chemistry, Ninth edition, Tata McGraw-Hill Publishing Company Limited. New Delhi.

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3. Samuel H. Maron and Carl F. Prutton, Principles of Physical Chemistry, Oxford & IBH Publishing Co. Pvt. Ltd, New Delhi, 1972.

4. W.J. Moore, Physical Chemistry, Longmans. 5. P.W. Atkins, Physical Chemistry, W.H. Freeman & Co. 6. S. Glasstone and D.Kews, Elements of Physical Chemistry, Macmillan & Co. Ltd. 7. B.S. Bahl, G.D. Tuli, and A. Bahl, Essentials of Physical Chemistry, S. Chand & Co.

Ltd., New Delhi. 8. K.K. Sharma and L.K. Sharma, A Textbook of Physical Chemistry, Vani Educational

Books, New Delhi.

Course Code: CHEM 1102 Physical Chemistry Practical-I

(Full Marks: 20 + 10 + 70 = 100; 1.0 Credit) 1. Determination of the formula of a hydrate. 2. Determination of relative atomic mass (i.e. atomic mass) of magnesium. 3. Determination of molecular weight of a volatile substance (condensable vapor) by

Victor Mayer’s method. 4. Determination of the molecular weight of a given liquid by steam distillation method. 5. Preliminary acid-base titration. 6. Acid-base titration with different indicators. Books Recommended:

1. Palit, Practical Physical Chemistry, Science Book Agency, Calcutta 2. Sharma, Practical Physical Chemistry, Vikas Publishing House Pvt. Ltd. 3. J.B. Yadav, Advanced Practical Physical Chemistry. 4. Khalique, A Text Book of Practical Chemistry, Ideal Library, Bangla Bazar, Dhaka. 5. O.P. Pandey, D.N. Bajpai, and S. Giri, Practical Chemistry, S. Chand & Co. Ltd, New

Delhi. 6. A. J. Mian and M.M. Hoque, Practical Chemistry, Student Publications, Dhaka. 7. A. Findlay, Longmans, Practical Physical Chemistry, Green and Company Ltd.

Course Code: CHEM 1103 Inorganic Chemistry I (Introductory Concepts)

(Full Marks: 20 + 10 + 70 = 100; 2 Credits) 1. Atomic Structure (Quantum Mechanical Approach): Fundamental particles,

Cathode rays, Mass and charge of electrons, Radioactivity, �-particle scattering experiment (Rutherford atom model), Isotopes, Electromagnetic radiations and

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spectrum, Atomic spectra, Planck’s quantum theory and photoelectric effect, Bohr’s model of hydrogen atom, Emission spectrum of atomic hydrogen, Quantum numbers, Refinements to Bohr’s atom model: Bohr-Sommerfield model, Pauli’s exclusion principle, Aufbau Principle, Hund’s rule.

2. Periodicity of the Elements: Periodic law, Modern periodic table and classification

of elements, Electronic configuration using periodic table, Diagonal relationship, Periodic properties-ionization energy, electron affinity, atomic radius, electronegativity, ionic radii, metallic character, melting and boiling points, Usefulness and limitations of periodic table.

3. The Chemical Bonds: Overview, Types of bond, Transition between main types of

bonding, Lewis formula, Octet rule and its exceptions. (a) Ionic Bond: General description, Energy changes in ionic bond formation,

Limitations to form ions, Fajans’s rule, Partial covalent nature of ionic compounds, Lattice energy and Born-Haber cycle, Factors influencing formation of ionic bond.

(b) Covalent Bond: General description, Energy change during bond formation,

Covalency and maximum covalency of an element, Valence bond theory: general description, sigma and pi bonds, hybrid orbitals, molecular geometry and directional bonding-valence shell electron pair repulsion theory; shapes of different covalent molecules according to VSEPR theory, effect of electronegativity on bond angle. Resonance; resonance energy, conditions necessary for resonance, Dipole moment, Non-polar and polar covalent bonds, Molecular orbital theory: principles of molecular orbital theory, bonding and antibonding molecular orbitals, their significance and characteristics, stability of molecules, bond order, MO diagram of simple diatomic molecules.

(c) Coordination bond, Metallic bond, Hydrogen bond, van der Waals forces. 4. Inorganic Nomenclature: Prefixes and affixes used in inorganic nomenclature, Use

of enclosing marks, numbers, letters and italic letters, names for cations, anions, radicals, heteropoly anions, names of acids, salts, salt like compounds and complex compounds.

5. Inorganic Polymers: Chain and network polymers, Silicon polymers, Boron nitrogen

polymers, Sulphur-nitrogen polymers, Phosphonitrilic compounds, Fluorocarbons: Preparation, structure and uses, Chemistry of fullerenes.

Books Recommended:

1. J. D. Lee, Concise Inorganic Chemistry, ELBS with Chapman & Hall, Croatia. F.A.Cotton, G. Wilkinson and P.L. Gaus, Basic Inorganic Chemistry,Wiley-India.

2. Raymond Chang Chemistry, McGraw-Hill, Inc., New York. 3. S. Prakash, G.D. Tuli, S.K. Basu, and R.D. Madan, Advanced Inorganic Chemistry,

Vol. 1& 2, S. Chand & Co. Ltd., New Delhi. 4. K. Kundu, Atomic Structure and Periodic Table, Bangla Academy, Dhaka.

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5. K. Kundu, Chemical Bonding and Shapes of Molecules, Bangla Academy, Dhaka. 6. K. Kundu, Chemistry of Inorganic Polymers, Bangla Academy, Dhaka.

Course Code: CHEM 1104 Qualitative Inorganic Practical-I

(Full Marks: 20 + 10 + 70 = 100; 1.5 Credits)

1. Introducing some common apparatus and reagents

a. Use and technical know how of analytical balance, b) Use of graduated glassware.

2. Some basic techniques:

a. Preparation of the substance for analysis and weighing the sample

b. Preparation of the solution of various samples in differing concentration

expression.

3. Systematic qualitative analysis of inorganic substances

a. Physical appearance

b. Preliminary dry test

4. Removal of interfering acids for systematic examination of bases in solution

5. Analysis of insoluble substances Books Recommended:

1. G.H. Jeffery, J. Bassett, J. Mendham and R.C. Denney: Vogel’s Qualititative Inorganic Analysis, Longman Scientific & Technical, New York.

2. A. J. Mian and M.M. Hoque, Practical Chemistry, Student Publications, Dhaka. 3. O.P. Pandey, D.N. Bajpai, and S. Giri, Practical Chemistry, S. Chand & Co. Ltd, New

Delhi. 4. E.S. Gilreath, Experimental Procedures in Elementary Qualitative Analysis, Mcgraw-

Hill.

Course Code: CHEM 1105 Organic Chemistry I (Fundamental Concepts)

(Full Marks: 20 + 10 + 70 = 100; 2 Credits) 1. Review and Background: Review and background: Origin of organic chemistry;

The structural theory; Electronic structure of carbon and hybridization; Atomic orbital, Molecular orbital, Covalent bond, Lewis model of bonding, Octet rule, Shape of molecules and bond angle, Polar and non-polar molecules, Dipole moment, Resonance, Inductive effect, Mesomeric effect, Functional groups.

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2. Aliphatic Hydrocarbons: (a) Alkanes: Nomenclature of alkanes, Structure, Isomerism in alkane,

conformations: ethane, butane; sources and preparations; Wurtz reaction and its importance, Physical and chemical properties, Reactions of alkane, Mechanism of halogenation; Free radicals, cabocations, carbanions and their stability study; Electrophiles and nucleophiles, Octane number.

(b) Alkenes: Alkenes: Classification by structure: the family, Nomenclature (E, Z-), Cis-trans isomerism in alkenes and cycloalkanes, configuration, Structure and preparation, Physical and chemical properties, Reactions of the carbon-carbon double bond: electrophilic and free radical addition, Markovnikov and anti-Markovnikov rule, Synthetic application of oxidation by O3, KMnO4, peracids, etc., Polymerization of alkene, Analysis of alkene. (c) Dienes: Structure, Nomenclature, Preparation, Reactions, Diels-Alder Reaction, Hyperconjugation, Stability of conjugated dienes, Polymerization. (d) Alkynes: Structure & bonding; Nomenclature, Source and preparations, Physical and chemical properties, Reaction of alkynes, Acidity of alkynes, Analysis of alkynes.

3. Aromatic Hydrocarbons & Arenes: Source, structure and resonance of benzene,

The concept of aromaticity, Huckel rule, Nomenclature of benzene derivative, Distribution and polysubstitution: orientation, Preparation, Electrophilic substitution with mechanism: nitration, sulphonation, halogenation, alkylation, acylation, Addition and oxidation reactions.

4. Alkyl and Aryl Halides: Structure, Nomenclature, Preparation, Physical properties,

Substitution and elimination reactions with mechanism (SN1, SN2, E1 and E2), Grignard reagent, Halocarbons-DDT, gammexane- their uses and residual effect in the environment.

Books Recommended:

1. R.T. Morrison & R. N. Boyd, Organic Chemistry; Study Guide to Organic Chemistry, Prentice Hall.

2. T.W.G. Solomon, Organic Chemistry, John Wiley & Sons. 3. B.S. Bahl and A. Bahl, Advanced Organic Chemistry, S. Chand & Co. Ltd., New

Delhi. 4. I.L. Finar, Organic Chemistry, Vol. 1 & 2, Longmans, Green & Co. 5. A. Streitweiser, C.H. Heathcock and E.M. Kosower, Introduction to Organic

Chemistry, Macmillan Pub. Co. 6. W.H. Brown and C.S. Foote, Organic Chemistry, Saunders College Pub. 7. R.W. Griffin Jr., Modern Organic Chemistry, McGraw Hill. 8. P. Sykes, A Guide Book to Mechanism in Organic Chemistry, Orient Longman. 9. Pine, Organic Chemistry, McGraw Hill.

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Course Code: CHEM 1106 Calculus


1. Basic Concepts of Set Theory: Functions, Limit, Continuity, Differentiability, Derivatives, Techniques of differentiation.

2. Application of the Derivatives: Maximum and minimum values, Taylor’s series,

Maclaurin’s series, Exponential and Trigonometric series. 3. Partial Differentiation: Maximum and minimum values of multivariate functions. 4. Indefinite Integrals: Techniques of integration, Definite integrals, Multiple integrals, �- and � functions, Application of integration: areas of plane curves, volumes and surface areas of solids of revolutions.

Books Recommended:

1. T.M. Apostol, Calculus, Wiley International Edition. 2. E. Steiner, The Chemistry Math Book, Oxford University Press. 3. R. Ellis and D. Gulick, Calculus with Analytic Geometry, HBJ.

Course Code: CHEM 1107

Mechanics and Properties of Matter and Waves (Full Marks: 20 + 10 + 70 = 100; 3 Credits)

1. Vector Analysis: Definition, Vector and scalar quantities, vector addition and subtraction, Scalar and vector products, Vector and dot product of two vectors, Triple products, Derivatives of vector, Gradient, divergence and curl of a vector.

2. Conservation of Energy and Linear Momentum: Conservative and non-conservative forces and systems, Conservation of energy and momentum, Center of mass, Collision problem.

3. Rotational Motion: Rotational motion, Rotational quantities as vectors, Rotational variables, Rotation with constant angular acceleration, Relation between linear and angular kinematics of a particle in circular motion, Torque and angular momentum, Moment of inertia, Rotational dynamics of a rigid body, Parallel axis and perpendicular axis theorem, Calculation of moment of inertia, Combined translational and rotational motion of rigid body.

4. Gravitation: Keplar’s laws, Newton’s law, Gravitational field and gravitational potential energy, Determination of gravitational constant and acceleration due to gravity, Gravitational attraction of sphere, Mass and density of the earth, Escape velocity, Acceleration due to gravity, Compound and Kater’s pendulum, Motion of planet and satellites.

5. Elasticity: Moduli of elasticity, Poison’s ratios, Relation between elastic constants and their determination, Cantilever, Flat spiral spring.

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6. Surface Tension: Definition, Molecular theory, Surface tension and surface energy, Adhesive and cohesive forces, Pressure inside a soap bubble, Contact angle.

7. Fluid Dynamics: Viscosity and coefficient of viscosity, Posseule’s equation, Determination of the coefficient of viscosity of liquid by Stock’s method, Bernoulli’s theorem and its applications, Torricelli’s theorem, Venturimeter.

8. Oscillatory Motions: Hook’s law, Simple harmonic motion, Lassajous figures,

Combination of harmonic motions, Damped harmonic motion, Forced oscillation and resonance.

9. Waves in Elastic Media: Physical description of a wave, Types of waves, Traveling waves, Equation of a traveling wave, Speed of propagation of waves in a stretched string, Transmission of energy of a traveling wave, Superposition principle, Group and phase velocity.

Books Recommended:

1. D. Halliday, R. Resnick and K. Krane: Physics Vol.1, John Wiley. 2. M. Spiegle: Vector Analysis, McGraw-Hill Inc., Singapore 3. D.S. Mathur: Elements of Properties of Matter, S. Chand & Co. 4. Brij Lal & N. Subrahmanyam: Properties of Matter, S. Chand & Co. 5. F.W. Sears: Mechanics, Wave motion and Heat, Addison-Wesley 6. U.A. Mofiz: Mechanics, Properties of Matter and Waves

Course Code: CHEM 1108 Physics Practical-I

(Full Marks: 20 + 10 + 70 = 100; 1.0 Credit)

1. Determination of the Young’s modulus & rigidity modulus of a short wire by Searle’s dynamic method.

2. Experiment with spring to verify Hooke’s law for a spring.

3. Experiment with spring to observe the harmonic motion of the spring for different loads attached to it.

4. Determination of the moment of inertia of a fly wheel about its axis of rotation.

5. Determination of the value of ‘g’, acceleration due to gravity, by means of a compound pendulum.

6. Determination of the surface tension of water by capillary tube method.

7. Determination of the co-efficient of viscosity of a liquid by its flow through a capillary tube.

8. Determination the frequency of a tuning fork by Melde’s experiment. Books Recommended:

1. C.L. Arora: B.Sc. Practical Physics, S. Chand & Co. Ltd.

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2. Giasuddin and Shahabuddin: B.Sc. Practical Physics (3rd ed.), Hafiz Book Centre, Dhaka.

3. Harnam Singh: B.Sc. Practical Physics, S. Chand & Co. Ltd.

Course Code: CHEM 1109 Biology


1. Biology-The Study of Life: Definition of biology, Molecular organization, Reproduction, Development, Nature of science, Scientific methods, Evolution theory, Importance of biological science.

2. The Chemistry of Life: The stuff of life, Energy, Water, The chemical building block of life.

3. The Cells: The overview of cell structure, Structure of prokaryotes and eukaryotes, Cell ultra-structure: cell membrane, nucleus, golgi complex, mitochondria, chloroplasts, ribosome, nuclear pores, DNA and RNA, Comparison of viral, bacterial, animal and plant cells, Brief ideas about cell metabolism, cell continuity and cell cycle (division), Blood cell structures human and other chordate animals.

4. Cell–interaction with the Environment: Lipid foundation of membrane, Architecture of plasma membrane, Passive transport: diffusion, osmosis, Active transport: Na-K pump, proton pump.

5. The Structure and Function of Plant Tissue: Organization of Plant, Types of plant tissue, Types of plant cell, Tissue culture.

6. Animal Behavior: Genetic basis, Development, Adaptive, Social, Sociobiology and animal behavior.

7. Diversity of Life: Classification of living things, Major groups of microorganisms: virus, bacteria, fungi, and protozoa- general characteristics, classification, major groups and their importance in nature, non-cellular and cellular reproduction, infective diseases and their causes.

Books Recommended: 1. P.H. Raken and G.B. Johnson, Understanding Biology, McGraw-Hill, 1988. 2. S.S. Mader, Biology, McGraw-Hill, 1998. 3. Peter H. Raven, George B. Johnson, Jonathan B. Losos, Susan R. Singer, Biology

(7th ed.), Tata McGraw-Hill Publishers

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Course Code: CHEM 1110 Communicative English


1. Grammar: Clause: structure, function, variation and expansion; The noun in the clause: number, determiners; The pronoun in the clause: number, case, agreement and reference; The verb in the clause: form, tense, voice, mood, subject-verb agreement; The modifiers in the clause: adjective, adverb, infinitive, participles; The conjunctions and prepositions to suggest different relationships: time, space, cause, result, purpose, condition, exception, etc.;

2. Remedial Grammar: Identifying and correcting errors and weakness.

3. Vocabulary: Clues to the meaning of a word, Position in the clause, prefixes, suffixes, roots; Synonym and antonym; Revisiting and expanding vocabulary.

4. Listening: Fluency, Lexical resource, Grammatical accuracy and correctness.

5. Speaking: How to ask questions: make requests and give instructions; How to respond to queries: invitation and statements; How to introduce and thank: express gratitude, regret or appreciation; How to communicate in particular everyday situations, How to express different concepts: ability, possibility, futurity, necessity, obligation, assumption, regularity, continuity, arrangement, comparison, etc.

6. Reading: Summary completion, Matching headings to paragraphs, Identifying the

writer’s views; Multiple choice, Selecting factors, Table completion, Matching causes and effects, Sentence completion, Short answer questions.

7. Writing: Spelling, Punctuation, Indenting, Brackets, Abbreviation, Numbers and

fractions, Capitalization, Underlining, Hyphenation etc. Organization of writing- of sentences in paragraphs in essays and letters, Practical writing: personal and official correspondence, job application, CV, report writing.

Books Recommended: 1. Thomson and Martinet, Cobuild English Grammer, A Communicative of English,

Leech & Svartvik. 2. M. Swan, Practical English Usage, Oxford University Press. 3. N. Lewis, Word Power Made Easy, The Most Effective Vocabulary Builder in the

English language, W. R. Goyal Pub. 4. A.S. Hornby, Oxford Advanced Learner’s Dictionary, Oxford University Press.

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Course Code: CHEM 1201 Physical Chemistry II (Elements of Physical Chemistry-II)

(Full Marks: 20 + 10 + 70 = 100; 3 Credits) 1. Chemical Equilibrium: Chemical equilibrium, Dynamic equilibrium, Equilibrium

law and conditions to achieve chemical equilibrium, Equilibrium constant, Homogeneous and heterogeneous equilibria, Le Chatelier and Braun’s principle and its application, Response of equilibrium to temperature, concentration and pressure change and addition of catalyst, Van’t Hoff equation, Dissociation constant, Ostwald dilution law, Ionic equilibria, Solubility product, Common ion effect, pH, pOH, buffer solution , Distribution law, Application of the principles of chemical equilibrium to reactions of industrial importance.

2. Rates of Chemical Reaction (Chemical Kinetics): Reaction rate, order and

molecularity, Experimental determination of rates, Determination of order and rate constant, Dependence of rates on concentration and temperature, Rate laws and mechanism, elementary and complex reactions, Preliminary concepts of collision and transition state theories, Catalysis.

3. First Law of Thermodynamics: Systems and surroundings, Types of

thermodynamic systems, Thermodynamic processes, Work and heat, Expansion work, Internal energy, First law of thermodynamics, State functions and exact differentials, Derivation of expression for expansion work and its application at different conditions; Reversibility and maximum work, Enthalpy of a system, Enthalpy changes in various chemical and physical processes. Molar heat capacities, Heat capacities at constant volume and constant pressure, Joule-Thomson effect.

4. Thermochemistry: Law of conservation of energy, Heat of reaction, Exothermic and

endothermic processes, Change in enthalpy, Variation of enthalpy with temperature (Kirchoff’s equations), Different types of heats of reaction, Hess’s law and its application,.

5. The Colloids: Classification, Types of colloidal systems, Characteristics of lyophilic

and lyophobic sols, Preparation and purification of sols, Different properties of sols, Stability of sols, Gold number, Emulsions; their types and properties; Emulsification, Gels, Application of colloids.

6. Photochemistry: Photochemical processes, Laws of photochemistry, Quantum

efficiency, Primary and secondary photochemical processes and timescales, Photosensitized reactions, Fluorescence, Phosphorescence, Chemiluminescence, Photochemical equilibrium, Quenching, Energy transfer, Different photochemical reactions, LASER.

7. Catalysis and Kinetics of Heterogeneous Reactions: Types and characteristics of

catalysis, Theory of homogeneous catalysis, Function of a catalyst in terms of Gibbs free energy of activation, Theory of heterogeneous catalysis, Kinetics and effect of temperature on heterogeneous reactions, Acid-base catalysis, Mechanism and kinetics of acid-base catalysis.

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8. Surface Chemistry: Adsorption, absorption and sorption, Physisorption and

chemisorption, Adsorption isotherms, Freundlich, Langmuir and BET isotherms, Properties of liquid surfaces, Surface tension, Curved surfaces, Capillary action, Surface films, Surface pressure, Surface excess, Surface free energy.

Books Recommended:

1. M.M. Huque and M.A. Nawab, Principles of Physical Chemistry, Students’ Publications, Dhaka, 1974


3. W.J. Moore, Physical Chemistry, Longmans. 4. P.W. Atkins, Physical Chemistry, W.H. Freeman & Co. 5. S. Glasstone and D. Kews, Elements of Physical Chemistry, Macmillan & Co. Ltd. 6. B.S. Bahl, G.D. Tuli, and A. Bahl, Essentials of Physical Chemistry, S. Chand & Co.


Books, New Delhi. 8. Raymond Chang, Chemistry, ninth edition, The McGraw-Hill Company

Course Code: CHEM 1202 Physical Chemistry Practical-II

(Full Marks: 20 + 10 + 70 = 100; 1.5 Credits) 1. Partition coefficient of iodine between water and carbon tetrachloride.

2. Partition coefficient of between water and toluene and study of association of benzoic

acid or Study of the adsorption of acetic acid or charcoal and examine the validity of

Freundlich’s adsorption isotherm and Langmuir’s adsorption isotherm.

3. Determination of the integral heat of solution of solids calorimetrically.

4. Determination of heat of solution from solubility measurements.

5. Determination of the solubility product of Ca(OH)2 in H2O and to study the effect of

added CaCl2 on the solubility of Ca(OH)2.

6. Verification of the Hess’s law of constant heat summation

7. Determination of the equilibrium constant for the reaction KI + I2 � KI3.

Books Recommended:

1. M.M. Huque and M.Y.A. Mollah, Principles of Physical Chemistry, Fully Revised Edition, Brothers’ Publication, Dhaka, January, 2009.


3. Palit, Practical Physical Chemistry, Science Book Agency, Calcutta.

14

4. Sharma, Practical Physical Chemistry, Vikas Publishing House Pvt. Ltd. 5. J.B. Yadav, Advanced Practical Physical Chemistry, Goel Publishing house, Meerut 6. Khalique, A Text Book of Practical Chemistry, Ideal Library, Bangla Bazar, Dhaka. 7. O.P. Pandey, D.N. Bajpai, and S. Giri, Practical Chemistry, S. Chand & Co. Ltd, New

Delhi. 8. A. J. Mian and M.M. Hoque, Practical Chemistry, Student Publications, Dhaka. 9. A. Findlay, Practical Physical Chemistry, Longmans, Green and Company Ltd. 10. D.T. Burns and E.M. Rattenbury, Introductory Practical Physical Chemistry, Elsevier

Course Code: CHEM 1203 Inorganic Chemistry II (Introductory Concepts)

(Full Marks: 20 + 10 + 70 = 100; 2 Credits) 1. Acids and Bases: Modern concepts of acids and bases: Arrhenius concept, Bronsted-

Lowry concept, Lewis concept, Limitations, Conjugate acids and bases, Classification of Bronsted acid-bases, Acid-base strength, Hard soft acid base principle (HSAB principle), pH, pOH, Buffer solution and buffer action, Henderson-Hasselbalch equation, Acid-base indicator, pH curve and indicator range, choice of suitable indicator, Theories of acid-base indicators.

2. Types of Reactions: Acid-base reactions, double decomposition reactions,

precipitation reactions, substitution reactions, condensation reactions, addition reactions, elimination reactions, isomerization reactions, polymerization reactions, oxidation-reduction reactions, Electronic concept of oxidation and reduction, oxidation state and oxidation numbers, assignment of oxidation numbers, balancing of redox reactions, oxidation-reduction potentials, oxidizing reducing agents, Prediction of redox reaction.

3. Solvent Chemistry: Solvent properties; donor and acceptor properties, Classification

of solvents: protic and aprotic solvents, chemistry of some non- aqueous solvents: properties of ionizing solvents, acid base phenomenon in non-aqueous systems, Studies of some typical non-aqueous ionizing solvents: liquid NH3, liq. Sulfur dioxide, hydrogen fluoride, liquid N2O4, BrF3, anhydrous sulphuric acid, acetic acid, liq. H2S.

4. Symmetry and Structure: Molecular Symmetry; symmetry operations and elements;

symmetry point group; assigning of molecules to point groups; Symmetry of orbitals. 5. Electron Deficient and Nonstoichiometric Compounds: (a) Boron hydrides and

their derivatives, properties and studies of their bonding and structures; the borohydrides, (b) Metal carbides, classification, structure formation and uses, Graphite compounds.

Books Recommended:

1. F.A.Cotton, G. Wilkinson and P.L. Gaus, Basic Inorganic Chemistry,Wiley-India. 2. J. Huheey, Keiter & Keiter, Inorganic Chemistry, 5th ed., India.

15

3. G. L. Miessler & D. A. Tarr, Inorganic Chemistry, 3rd ed., Pearson, India. 4. Raymond Chang, Chemistry, McGraw-Hill, Inc., New York, 1994. 5. T. C. Waddington, Nonaqueous Solvents (Study in Modern Chemistry) Thomas

Nelson & Sons Ltd 6. S. Prakash, G.D. Tuli, S.K. Basu, and R.D. Madan, Advanced Inorganic Chemistry,

Vol. 1& 2, S. Chand & Co. Ltd., New Delhi. 7. K. Kundu, Oxidation-Reduction and Acid-Base Reactions, Bangla Academy, Dhaka.

Course Code: CHEM 1204 Qualitative Inorganic Practical-II


1. Identification of inorganic cations and anions in mixture by semi-micro qualitative

inorganic analysis.

2. Making of models of 7 crystal structures and common molecular structures. Books Recommended:

1. G.H. Jeffery, J. Bassett, J. Mendham and R.C. Denney: Vogel’s Qualitative Inorganic Analysis, Longman Scientific & Technical, New York.


Delhi. 4. E.S. Gilreath, Experimental Procedures in Elementary Qualitative Analysis, McGraw-

Hill.

Course Code: CHEM 1205 Organic Chemistry II (Fundamental Concepts)

(Full Marks: 20 + 10 + 70 = 100; 3.0 Credits) 1. Hydroxyl Compounds (Alcohols and Phenol): Structure, Nomenclature, Physical

properties (acidity and basicity of alcohols and phenols), Preparation, Important reactions of alcohols and phenols: substitution, esterification, oxidations, ring substitution, coupling with diazonium salts, Reimer-Tiemann reaction, Phenol-formaldehyde resin of phenol, The Pinacol-Pinacolon rearrangement, etc, Periodic acid oxidation of glycols.

2. Ethers, Sulphide and Epoxides: Structure, Nomenclature, Preparation, Williamson-ether synthesis, Physical properties, Reactions, Ethers as protecting groups, Crown ethers.

3. Carbonyl Compounds: (a) Aldehydes (Aliphatic & aromatic): Structure, Nomenclature, Relative Reactivity

of carbonyl compounds, General methods of preparations, Physical properties,

16

Reactions of aldehyde: nucleophilic addition to carbonyl compounds, oxidation and reduction, A simple study of mechanisms: Reimer-Tiemann reaction, Cannizzaro reaction, Aldol condensation reaction, Perkin reaction and Wittig reaction.

(b) Ketones (Aliphatic & aromatic): Structure, Nomenclature, General methods of preparations, Physical properties, Reactions: nucleophilic addition to carbonyl compounds, oxidation and reduction

4. Carboxylic Acids (Aliphatic & aromatic) & its Derivatives: Nomenclature,

Orbital picture, Hydrogen bonding, Acidity, Resonance effect and inductive effect on acidity, General methods of preparations and reactions of carboxylic acids: hydroxy acids, unsaturated acids, keto acids, synthesis using active methylene compounds, Derivatives of Carboxylic acids (esters, amides, acid halide and anhydride s), Relative reactivity of carboxylic derivatives.

5. Amines (Aliphatic & Aromatic): Nomenclature, Structure and basicity,

Preparations, Physical properties, Separation of amines, Reactions: alkylation, conversion into amides, oxidation, ring substitution in aromatic amines, Hoffmann degradation of quaternary ammonium hydroxides, Analysis of amines.

6. Nitro and Nitroso Compouds: General properties and resonance of aromatic nitro-

compounds, Synthesis, Reactivity, Reactions of aliphatic and aromatic nitro and nitroso compounds, Reduction of nitro compounds, TNT, TNB, Aromatic Diazonium salts: Preparation and reactions.

7. Alicyclic Compounds: Small and normal-size rings, their formation, Conformations:

cycloalkanes and bicycloalkanes, Bayer strain theory, Heat of combustion and relative stabilities of the cycloalkanes, Factors affecting stability of conformation, reactions, cis-trans isomerism in alicyclic system.

8. Polynuclear Aromatic Compounds: Nomenclature, General treatment, Numbering

in the rings and their resonance, Naphthalene, anthracene and phenanthrene: their sources, structures, syntheses, reactions and derivatives, chemical behavior of the derivatives.

Books Recommended:




Chemistry, Macmillan Pub. Co. 6. W.H. Brown and C.S. Foote, Organic Chemistry, Saunders College Pub. 7. R.W. Griffin Jr., Modern Organic Chemistry, McGraw Hill. 8. P. Sykes, A Guide Book to Mechanism in Organic Chemistry, Orient Longman.

17

Course Code: CHEM 1206 Organic Chemistry Practical-I (Fundamentals)


1. Introduction to basic laboratory equipment: Glassware and other personal items, Assembly and precaution in using glassware. Cleaning glassware, heating and cooling. Laboratory safety instructions.

2. Melting points and boiling points of Organic compounds: Discussion on melting point and boiling point, Determination of melting point of a solid, mixed melting points, Identification of typical functional groups in organic compound, Determination of boiling point of a liquid.

3. Recrystallization: Discussion on crystallization, Crystallization theory, Purification of benzoic acid or salicylic acid.

4. Drying: Drying technique of some organic compounds.

5. Distillation: Simple distillation, Fractional distillation, Steam distillation.

6. Solvent extraction.

7. Detection: Detection of N, S and halogens in organic compounds.

8. Solubility test and classification of the organic compounds Books Recommended: 1. H.D. Durst and G.W. Gokel, Experimental Organic Chemistry, McGraw-Hill Book

Company, New York, 1987. 2. Vogel’s Text Book of Practical Organic Chemistry, ELBS with Longman, 5th Edition. 3. L.F. Fiesser, K.L. Williamson, Organic Experiment, D.C. Health & Company

Lexington, Massachusetts, Toronto, 4th Edition. 4. R.L. Shriner, R.C. Fuson and D.Y. Curtin, Systematic Identification of Organic

Compounds, John Wiley Sons, Inc. New York, London, Sydney. 5. A.I. Vogel, Elementary Practical Organic Chemistry (Part 1), Longman.


Analytical Geometry and Ordinary Differential Equation (Full Marks: 20 + 10 + 70 = 100; 2.0 Credits)

SECTION A (Analytical Geometry-2D): 1. 2D: Cartesian polar co-ordinate, Transformation of co-ordinates, Translation and

rotation of axes, Invariants, Pair of straight lines, General equation of second degree

18

and reduction to standard form, Identification of conic, Circles and system of circles, Parabola, Ellipse, Hyperbola, Equation of conic in polar and parametric forms.

2. Solid (3D) Geometry and Plane: Coordinate systems and their transformations, the straight line and plane, The sphere.

SECTION B (Ordinary Differential Equation-ODE):

1. Ordinary Differential Equations of First Order and Second Order: General principles, Elementary standard types, linear equations with constant co-efficients. Books Recommended: 1. E. Steiner, The Chemistry Math Book, Oxford University Press. 2. S. Lang, Linear Algebra, Springer. 3. R. R. Stoll, Linear Algebra and Matrix Theory, McGraw-Hill. 4. R. Ellis and D. Gulick, Calculus with Analytical Geometry, HBJ. 5. K. Mohammad, A Text book of Co-ordinate Geometry and Vector Analysis, The

University Press. 6. A. F. M. Rahman & P. K. Bhattacharjee: A Textbook on Co-ordinate Geometry (two

and three dimensions) and Vector Analysis.

Course Code: CHEM 1208 Electricity and Magnetism


1. Electric Field: Charge & matter, Coulomb’s law, Electric field and field strength, Point charge in an electric field, Electric dipole, Electric field due to dipole, Dipole in an external electric field, Electric flux, Gauss’s law and its applications.

2. Electric Potential: Electric potential and field strength, Potential due to a point

charge, Electric potential energy, Calculation of field strength from electric potential. 3. Capacitors and Dielectrics: Capacitance-its calculation, Parallel plate capacitors

with dielectrics, Dielectrics and Gauss’s law, Dielectric constant, Energy stored in an electric field.

4. Current, Electromotive Force and Circuits: Electron theory of conductivity;

Conductor, semiconductor, insulators and superconductors; Current and current density, Resistance, Resistivity and conductivity, Ohm’s law, Electromotive force, Potential difference, Kirchhoff’s law and its applications, Single-loop and multi loop circuits, DC circuits with LR, RC, LC and LCR in series, AC circuits with LR, RC, LC, and LCR in series, Ammeters, voltmeter, ohmmeter, watt meter, frequency meter, AC/DC bridge, digital voltmeter.

19

5. Magnetic Field and Ampere’s Law: Magnetic field and field strength, Magnetic force on charge and current, Lorenz force, Torque on a current loop, The Hall effect, Circulating charges, Ampere’s law and magnetic field near straight wire, Two parallel conductors, Biot-Savart law, Magnetic materials & their properties.

6. Magnetic Induction: Faraday’s law of induction, Lenz’s law, Induction and electric

field, Inductance and its calculation, An IR circuit’s energy and the magnetic field, Energy density and magnetic field, Self and mutual inductance.

7. Thermoelectricity: Thermal e.m.f; Seeback, Peltier and Thomson Effects;

Thermoelectric thermometer, Thermocouple. Books Recommended:

1. D. Halliday and R. Resnicks, Fundamentals of Physics, Part II, John Wiley. 2. A.R. Rafiqullah, A.K.Roy & M.S.Huq, Concept of Electricity and Magnetism. 3. A. F. Kip: Fundamentals of Electricity and Magnetism, McGraw-Hill. 4. K.K. Tewari: Electricity and Magnetism with Electronics, S. Chand & Co. Ltd., New

Delhi. 5. H.D. Young and RA Freedman, University Physics, Pearson

20

Course Code: CHEM 2101 Chemical Thermodynamics and Phase Equilibrium


1. Second Law of Thermodynamics: The direction of spontaneous change, Dispersal of energy, Spontaneous process, Spontaneity and randomness, Second Law: statement, Entropy, Carnot cycle: search for a state function, Entropy change in isolated systems, Dependence of entropy on variables of a system, Entropy change in ideal gases, Entropy change in physical transformation, Entropy change in chemical reactions, Properties of the Gibbs energy, Gibbs energy and reversible work, Maxwell relations, Thermodynamic equation of states, Mathematical relationship between different thermodynamic quantities, Direction of chemical change, Dependence of free energy on pressure and temperature, Gibbs-Helmoltz equation, Equilibrium between phase: Clapeyron equation, Clausius-Clapeyron equation, Van’t Hoffs isotherm and isochore, Fugacity and activity, Chemical potential of a substance in pure state and in a mixture, Partial molar quantities and their determinations: Gibbs-Duhem equation, Thermodynamic limitations to energy conversion (refrigeration and liquefaction, heat pumps, chemical conversion).

2. Third Law of Thermodynamics: Nernst heat theorem, Statement of third law,

Evaluation of absolute entropies, Use of absolute entropies, Applications and limitations of third law.

3. Thermodynamic equilibrium constant, Equilibrium constant from thermal data,

Ellingham’s diagram, ATP –the carrier of energy, Thermodynamics of solution.

4. Phase equilibrium: Phase, Components and degrees of freedom, Phase rule and

phase diagram, Phase diagram of one component system: water, CO2, helium, Two component system, Vapor pressure diagram, Lever rule, Temperature-composition diagrams, Distillation of mixtures, Azetropes, Liquid-liquid and liquid-solid phase diagrams, Phase separation, Critical solution temperature, Distillation of partially miscible liquids, Eutectics, Incongruent melting, Phase diagram of three component system: triangular phase diagrams, Partially miscible liquids, Role of added salts, Stabilities of phases, Phase stability and phase transitions: thermodynamic criterion of equilibrium, Dependence of stability on condition, Location of phase of phase boundaries, Ehrenfest classification of phase transition.

Books Recommended:


2. W.J. Moore, Physical Chemistry, Longmans. 3. P.W. Atkins, Physical Chemistry, W.H. Freeman & Co. 4. S. Glasstone and D. Kews, Elements of Physical Chemistry, Macmillan & Co. Ltd. 5. B.S. Bahl, G.D. Tuli, and A. Bahl, Essentials of Physical Chemistry, S. Chand & Co.

Ltd., New Delhi.

21

6. K.K. Sharma and L.K. Sharma, A Textbook of Physical Chemistry, Vani Educational Books, New Delhi.

7. S. Glasstone, Thermodynamics for Chemists, Narahari Press.

Course Code: CHEM 2102 Physical Chemistry Practical-III


1. Determination of heat of neutralization of a strong base by a strong acid.

2. Determination of the phase diagram for the phenol-water system.

3. The pH value of a given solution by indicator method (using buffer solution of known

pH).

4. Determination of the liquid-liquid miscibility of partially miscible three liquid

system.

5. Study of molecular mass by measurements of physical properties:

a. Viscosity and density

b. Surface tension

c. Vapor pressure.

6. Determination of the partial molal volume of solutions (alcohol-water system) by

Westphal balance or density bottle (picknometer).

Books Recommended:

1. Palit, Practical Physical Chemistry, Science Book Agency, Calcutta 2. Sharma, Practical Physical Chemistry, Vikas Publishing House Pvt. Ltd. 3. J.B. Yadav, Advanced Practical Physical Chemistry, Goel Publishing House. 4. A. Khalique, A Text Book of Practical Chemistry, Ideal Library, Bangla Bazar,

Dhaka. 5. O.P. Pandey, D.N. Bajpai, and S. Giri, Practical Chemistry, S. Chand & Co. Ltd, New

Delhi. 6. A. J. Mian and M.M. Hoque, Practical Chemistry, Student Publications, Dhaka. 7. A. Findlay, Practical Physical Chemistry, Longmans, Green and Company Ltd.

Course Code: CHEM 2103 Chemistry of Element-I


1. Hydrogen and Hydrides (Group 1): Position in the periodic table: abundance and preparation of hydrogen, properties of molecular hydrogen; ortho and para hydrogen; hydrides; hydrogen ion, isotopes of hydrogen, hydrogen bonding, hydrogen as fuel.

22

2. Alkali Metal (Group 1): Occurrence and abundance, Electronic structure, Physical properties, Reaction with water, air and dinitrogen; oxides, hydroxides, peroxides and superoxides; biological importance.

3. Alkaline Earth Metal (Group 2): Occurrence and abundance, Electronic structure,

Physical properties, Reaction with water, air and acids and bases, oxides, hydroxides, peroxides, sulphates, nitrates and halides; Hardness of water; Biological role of Mg2+ and Ca2+, Synthetic application.

4. Chemistry of Boron and Carbon (Group 13 and 14): Occurrence, abundance and

extraction, General properties, Structure and allotropy of the elements, Reactions of boron, Chemical reactivity of carbon; carbides, oxides, and carbonates; oxides of silicon, Preparation of the metals as semiconductors, Allotropic forms.

5. Chemistry of Nitrogen and Phosphorus (Group 15): Occurrence, extraction and

uses, Electronic structure and oxidation states, Allotropic forms, Reactivity; Oxides of nitrogen and phosphorus, hydrides; oxiacid of phosphorus, Amino basic compounds, phosphonitrillic compounds.

6. Chemistry of Oxygen and Sulphur (Group 16): Abundance, extraction and uses,

Electronic structure and oxidation states, General properties, Structure and allotropy of the of the elements, Chemical reactivity of oxygen and Sulphur, General properties of oxides, oxiacid of Sulphur, Sulphur catenation.

7. Chemistry of Halogen (Group 17): Occurrence, abundance and extraction, General

properties, Reactivity, Charge transfer compounds of halogens, oxides, oxo-acids and their salts, Halides, Interhalogen compounds and pseudohalogen compounds.

8. Chemistry of Inert Elements (Group 18): Occurrence, recovery and uses,

Electronic structure, Physical and chemical properties of the noble gases, Xenon fluoride complexes, Structure and bonding in xenon compounds.

Books Recommended: 1. J. D. Lee, Concise Inorganic Chemistry, ELBS with Chapman & Hall, Croatia, 1996. 2. F.A. Cotton, G. Wilkinson and P.L. Gaus, Basic Inorganic Chemistry,Wiley-India. 3. F.A. Cotton, G. Wilkinson and P.L. Gaus, Advanced Inorganic Chemistry,Wiley-

India. 4. N.N. Greenwood and A. Earnshaw, Chemistry of the Elements, Butterworth-

Heinemann. 5. S. Prakash, G.D. Tuli, S.K. Basu, and R.D. Madan, Advanced Inorganic Chemistry,

Vol. 1& 2, S. Chand & Co. Ltd., New Delhi. 6. K. Kundu, Chemistry of Main Group Elements (in Bangla), Bangla Academy, Dhaka.

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Course Code: CHEM 2104 Quantitative Inorganic Practical-I


1. Neutralization titrations: (i) Standardization of approximately 0.1M NaOH solution against succinic/oxalic

acid. (ii) Standardization of approximately 0.1M HCl by titration with 0.1M NaOH (using

both methyl orange and methyl red indicator). 2. Redox titrations: (i) Determination of ferrous ion using standard KMnO4 solution. (ii) Determination of ferric ion using standard K2CrO7 solution. (iii) Determination of ferrous ion by oxidation with standard KMnO4 solution. (iv) Determination of ferric ion with standard KMnO4 solution. 3. Iodomertic titrations: (i) Standardization of sodium thiosulphate solution using dichromate solution. (ii) Determination of copper iodometrically with standard 0.1 Na2S2O3 solution. Books Recommended:

1. G.H. Jeffery, J. Bassett, J. Mendham and R.C. Denney: Vogel’s Quantitative Chemical Analysis, Longman Scientific & Technical, New York.

2. J. Mian and M.M. Hoque, Practical Chemistry, Student Publications, Dhaka. 3. Pandey, D.N. Bajpai, and S. Giri, Practical Chemistry, S. Chand & Co. Ltd, New

Delhi. 4. K. Kundu, Practical Inorganic Chemistry (in Bangla), Bangla Academy. 5. K. Kundu, Practical Inorganic Analysis (in Bangla), Bangla Academy.

Course Code: CHEM 2105 Organic Chemistry III


1. Isomerism: Definition, Structural isomerism, Stereoisomerism: geometrical isomerism-conditions, explanations, interconversion, geometrical isomerism of olefines and cyclic aliphatic compounds; optical isomerism- optical isomerism due to asymmetric carbon atoms, chirality, optical activity, specific rotations, enantiomerism, diastereoisomerism, recemic mixture, meso compounds, Racemic modification, nature, formation, properties and their resolutions, absolute and relative configurations, and their notations, Asymmetric synthesis.

2. Chemistry of the Compounds Containing C-S, C-N and C-P Bonds: Organo-Sulfur Compounds: Nomenclature, Physical properties, Preparation and reactions of thiols, mercaptans, thioethers, thioaldehydes, thioketone, thioacids, sulphonic acids and their derivatives, Basic Structural feature of organo-phosphorus compounds; Synthesis and reactions, Chemical properties of alkyl-, dialkyl- alkylaryl phosphines,

24

phosphonium salts, Organo-nitrogen compounds: structures, shape, physical and chemical properties of nitriles, thiocyanates, carbamates, and ureas, imines and oximes, azides and azo compounds.

3. Carbanions:

I. Aldol and Claisen Condensations: Acidity of � hydrogens, Reactions involving carbanions, Aldol condensation, Crossed aldol condensation, Reaction related to the aldol condensation, Claisen condensation. II. Malonic Ester and Acetoacetic Ester Syntheses: Carbanions in organic synthesis, Malonic ester synthesis of carboxylic acids, Acetoacetic ester synthesis of ketones, Decarboxylation of �-keto acids and malonic acids, Direct and indirect alkylation of esters and ketones.

4. Bi-functional Compounds: 1,3-dienes, �, �-unsaturated carbonyl compounds,

Preparation, Electrophilic and nucleophilic addition, Michael addition, Diels-Alder reaction, Hydoxy ketone, Hydroxy acids.

5. Heterocyclic Compounds: Aromaticity of heterocycles, Sources, Isolation,

Structures and reactions of five membered ring heterocycles: pyrrole, furan, and thiophene, Structures and reactions of five membered ring heterocycle compounds containing two hetero atoms: imidazole and pyrimidine, oxazole and thiazole, Six membered ring heterocycles: pyridine, pyrrole, Heterocyclic compounds having fused rings: chemistry and structure of indole, benzofuran, benzothiophene, quinoline and isoquinoline.

6. Color, Dyes and Pigments: Theories of color and color conjugated systems,

Nomenclature, Classification, Raw materials for synthesis of dyes. 7. Synthesis of Some Important Organic Drugs: (a) Sulpha Drugs: Sulphanilamide, Sulphapyridine, Sulphathiazole, Sulphadiazine,

Sulphamezathine, Sulphaguanidine, Prontosil, Chloriamin-T;

(b) Antimalerials: Plasmoquin, Mepacrine;

(c) Fever Sinking Drugs: Paracetamol, Aspirin, Phenacetin;

(d) Barbiturates: Barbituric acid, Uramil, Alurate, Barbital, Phenobarbital;

(f) Sweetening Agents: Saccharin, Dulcin and Aspartame.

Books Recommended:



Delhi. 4. I.L. Finar, Organic Chemistry, Vol. 1 & 2, Longmans, Green & Co.

25

5. A. Streitweiser, C.H. Heathcock and E.M. Kosower, Introduction to Organic Chemistry, Macmillan Pub. Co.

6. W.H. Brown and C.S. Foote, Organic Chemistry, Saunders College Pub. 7. R.W. Griffin Jr., Modern Organic Chemistry, McGraw Hill. 8. P. Sykes, A Guide Book to Mechanism in Organic Chemistry, Orient Longman. 9. E. Eliel, Stereochemistry of Carbon Compounds, McGraw-Hill. 10. Acheson, An Introduction to Heterocyclic Compounds, Academic Press.

Course Code: CHEM 2106 Preparative Organic Chemistry Practical


1. Preparation of aspirin: O-acetylation (esterification) of salicylic acid. 2. Preparation of acetanilide: N-acetylation of aniline. 3. Preparation of p-nitroacetanilide: Nitration of acetanilide. 4. Alkaline hydrolysis of aspirin. 5. Acidic hydrolysis of p-nitroacetanilide. 6. Preparation of dibenzalacetone (condensation reaction between benzaldehyde and

acetone). 7. Oxidation of cyclohexanol to cyclohexanone. 8. Reduction of 3-nitro acetophenone with Sn/HCl. 9. t-Butanol from t-butyl chloride. 10. Butyl acetate from butanol and acetic acid. 11. Cyclohexene from cyclohexanol. 12. Benzoic acid from toluene.

Books Recommended:

1. Louis F. Fieser, L. Kenneth F. Williamson, Organic Experiments, D.C. Health and Company, Lexington, Massachusetts.

2. H. D. Durst and G.W. Gokel, Experimental Organic Chemistry, McGraw-Hill Book Company, New York, 1987.

3. Brian S. Furniss, Vogel’s Text Book of Practical Organic Chemistry, ELBS with Longman, 5th Edition.

Course Code: CHEM 2107 Computing and Information Technology in Chemistry

(Full Marks: 20 + 10 + 70 = 100; 2 Credits) Section-A 1. Computer and Information Technology: Basic Concepts; How computer system

works; Types of modern digital computers. 2. Introduction to Windows and MS-DOS: Microsoft word processing in detail. 3. Microsoft office: Word, Excel, Power point, Access, Integrating. 4. An overview idea of computer language and software.

26

Section-B 1. Writing chemistry texts involving chemical formulae, Molecular structure, Drawing

using Chem Office: 2D and 3D, ISIS/Draw, ACD/ChemSketch, Jmol. 2. 3D molecular model building software. 3. Advanced word processing-Tabs, tables, use of the equation editor in chemistry. 4. MS Excel/Origin/Sigmaplot-Chemical spreadsheets (use of the function wizard,

formulae) and graphs in chemistry (line graphs and scatter plots). 5. Use of Ortep 3. 6. Use of internet.

Book Recommended:

1. Sarah E. Hutchinson and Glen J. Coulthard, Microsoft Office 2000, McGraw-Hill Irwin, New York.

2. K.C. Laudon, Interactive Computing, McGraw-Hill Companies, Inc. New York, 1996.

3. Mahbubur Rahman, Microsoft Office XP, 2003, 2007, Systech Publications Publication, 38/3 Bangla Bazar, Dhaka.

4. Molecules-3D: 3D molecular model building software for windows, Quick Start Guide, Version 2.0, Molecular Arts Corporation, USA.

5. Homepages of ISIS/Draw, ACD/ChemSketch and Jmol.

Course Code: CHEM 2108 Mathematical Methods

(Full Marks: 20 + 10 + 70 = 100; 3 Credits) 1. Fourier series, Fourier transformation, Fourier integral, Application of Fourier series. 2. Laplace transformation, inverse Laplace transformation, Application of Laplace

transformation in ordinary and partial differential equation. 3. Line integral, Volume integral, Surface integral, Green’s theorem, Gauss’s

divergence theorem, and Stoke’s theorem. 4. Partial Differential Equation (PDE): Wave equation, Diffusion equation, Laplace

equation, Poisson equation, Schroedinger equation, Method of separation of variables, Method of Laplace and Fourier transforms, Formation of PDE, Solution system of PDE, Legendre and Bessel functions, Laguree and Hermite polynomial.

Books Recommended:

1. E. Steiner, The Chemistry Math Book, Oxford University Press. 2. S. Lang, Introduction to Linear Algebra, Springer. 3. R. R. Stoll, Linear Algebra and Matrix Theory, McGraw-Hill. 4. R. L. Burden and J. D. Faires, Numerical Analysis, Brooks Cole.

27

Course Code: CHEM 2109 Electronics and Optics


1. Alternating Current and AC-Circuit Analysis: The simple AC generator, Alternating voltage and current and their graphical representation, PMS value of an AC circuit, AC voltage applied to resistors, capacitors and inductors, Alternating current and voltage in a series LR and in a series PC circuit, LCR circuits, Power, Dissipation in an AC circuit, Transformer.

2. Fundamental Properties of Electronic Devices: Conduction in solids, Energy band picture, Doping of semiconductors, Junction diodes, Circuit properties of a P.N. junction, Junction transistors.

3. Nature and Propagation of Light: Properties of light, Wave theory and Huygen's principles, Theories of light.

4. Interference: Coherent Source, Young's experiment, Bi-prism, Color of thin film, Superposition of waves, Newton’s rings.

5. Diffraction: Fresnel and Fraunhoffer diffraction, Diffraction through single - slit, double slit, Diffraction grating, Formation of spectra.

6. Polarization: Polarized and un-polarized light, Plane, Polarization by reflection, Elliptic and circular polarization, Double refraction, Rotatorary poarization, Polarimeter.

Books Recommended: 1. V.K. Mehta and Rohit Mehta, Principle of Electronics, S. Chand & Co. Ltd., New

Delhi. 2. B.L. Theraja, Basic Electronics (Solid State), S. Chand & Co. Ltd., New Delhi. 3. F.A. Jenkins and H.E. White, Fundamental of Optics, McGraw-Hill. 4. Brij Lal and N. Subrahmanyam, A Text Book of Optics, S. Chand & Co. Ltd., New

Delhi. 5. B.K. Mathur, Principles of Optics. 6. D.S. Mathur, Geometrical & Physical Optics.

28

Course Code: CHEM 2201 Electrochemistry


1. Electrolytes in Solution: Electrolytic conduction, Classification of electrolytes, Laws of electrolysis, Mechanism of electrolytic conduction, Electrolytic conductance, Cell constant, Kohlrausch’s law of independent migration of ions and its application, Ionic mobility, Degree of ionization and conductance, Solubility of sparingly soluble salts, Conductometric titration, Transport number and its determination, Factors affecting transport number, Application of conductance measurement, Kinetic measurements, Acid-base titrations, Precipitation titration, Common ion effect, The ionic product of water, pH, pOH and buffer, Concepts of acids and bases, Hydrolysis, Solubility product.

2. Theories of Electrolytes: The Arhenius theory of electrolytic dissociation, The Debye-Huckel theory of electrolytic solution and limiting law including its test, Determination of activity coefficient, Debye-Huckel-Onsager equation: limitations and applications.

3. Electrochemical Cells: Electromotive force, Galvanic cell and electrolytic cell, Reversible and irreversible cells, Standard cell, Free energy and EMF cells, Different types of cell used in practical purpose (Quinhydrone electrode, Daniel cell and lead storage battery hydrogen electrode, standard cell, calomel electrode.), Half reactions, Electrolyte concentration cell, Electrode concentration cell, Liquid junction potential, Derivation and minimization of junction potential, Cell reaction, Potential and emf, Nernst equation, emf of concentration cells, Cells at equilibrium, Standard potential, Electrochemical series, Solubility constant, Analytical applications of emf measurements: Potentiometric titrations, Different parameters determined by potential measurements: measurement of pH and pK, equilibrium constant, activity coefficient, transport number, oxidation state etc, Thermodynamic functions from emf measurements.

4. Electrode Processes: Polarization: concentration, activation and Ohmic polarization,

Polarographs for classical d.c. polarography; Pulse polarography, Rapid scan polarography, Sinusodial a.c. polarography and voltammetry.

5. Electrokinetics: Theory of ion selective electrodes; Electrode kinetics; Butler-

Volmer equation; Potential limits current density; β-factor. Books Recommended:

1. M.M. Huque and M.Y.A. Mollah, Principles of Physical Chemistry, Fully Revised Edition, Brothers’ Publication, Dhaka, January, 2009.



4. W.J. Moore, Physical Chemistry, Longmans. 5. P.W. Atkins, Physical Chemistry, W.H. Freeman & Co.

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6. S. Glasstone and D. Kews, Elements of Physical Chemistry, Macmillan & Co. Ltd. 7. B.S. Bahl, G.D. Tuli, and A. Bahl, Essentials of Physical Chemistry, S. Chand & Co.


Books, New Delhi. 9. G.W. Castellan, Physical Chemistry, Addision-Wesley Publishing Co. 10. G.M. Barrow, Physical Chemistry, McGraw-Hill Book Co.

Course Code: CHEM 2202 Electro-analytical Practical


1. Measurement of cell constant of a conductance cell and measurement of the solubility of a sparingly soluble salt by conductometric method.

2. Determination of conductivity of natural water. 3. Determination of the equivalent conductance at infinite dilution and dissociation

constant of a weak acid. 4. Conductometric titration of: (a) strong acid, (b) weak acid and to draw their

neutralization curves. 5. Potentiometric titration of: (a) strong acid, (b) weak acid and to draw their

neutralization curves. 6. Determination of the half wave potential of the cadmium ion in 1M potassium

chloride solution. 7. Determination of the standard electrode potential of Zinc and Copper. Books Recommended:

1. Palit, Practical Physical Chemistry, Science Book Agency, Calcutta 2. Sharma, Practical Physical Chemistry, Vikas Publishing House Pvt. Ltd. 3. J.B. Yadav, Advanced Practical Physical Chemistry, Goel Publishing House. 4. Khalique, A Text Book of Practical Chemistry, Ideal Library, Bangla Bazar, Dhaka. 5. O.P. Pandey, D.N. Bajpai, and S. Giri, Practical Chemistry, S. Chand & Co. Ltd, New

Delhi. 6. A. J. Mian and M.M. Hoque, Practical Chemistry, Student Publications, Dhaka. 7. A. Findlay, Practical Physical Chemistry, Longmans, Green and Company Ltd.

Course Code: CHEM 2203 Chemistry of Element-II


1. Introduction of Transition Element: Definition, periodic classification, general properties of transition elements and their ions: size, ionization energy, color,

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magnetic properties general features of 1st, 2nd and 3rd row transition elements, Difference between the first row and the other two rows transition elements.

2. Chemistry of Titanium and Vanadium Group (Groups 4 & 5): Occurrence,

abundance, extraction and uses; Oxidation states; General properties; Reactivity; Some common compounds.

3. Chemistry of Chromium and Manganese Group (Groups 6 & 7): Occurrence,

abundance, extraction and uses; Oxidation states; General properties; Reactivity; Some common compounds; Biological importance.

4. Chemistry of Iron group (Group 8): Occurrence, abundance, extraction and uses;

Oxidation states; General properties; Reactivity; Some common compounds; Steel making; Bioinorganic chemistry of iron.

5. Chemistry of Cobalt and Nickel (Group 9 & 10): Occurrence, abundance,

extraction and uses; Oxidation states; General properties; Reactivity; Some common compounds; Horizontal comparisons in the iron, cobalt and nickel group.

6. Chemistry of Copper and Zinc Group (Group 11 & 12): Occurrence, abundance,

extraction and uses; Oxidation states; General properties; Reactivity; Some common compounds; Biological role of Cu and Zn; Toxicity of Cd and Mg.

7. Chemistry of Lanthanides: General features, lanthanide contraction, variable

valency, magnetic and spectral properties, separation of lanthanides, common lanthanide compounds, comparison of lanthanide ions and transition metal ions.

8. Chemistry of Actinides: General features, actinide contraction, occurrence and

properties of the elements, general chemistry of actinides, separation of the Actinides, Superactinides.

Books Recommended: 1. J. D. Lee, Concise Inorganic Chemistry, ELBS with Chapman & Hall, Croatia, 1996. 2. F.A. Cotton, G. Wilkinson and P.L. Gaus, Basic Inorganic Chemistry, Wiley-India. 3. F.A. Cotton, G. Wilkinson and P.L. Gaus, Advanced Inorganic Chemistry, Wiley-

India. 4. N.N. Greenwood and A. Earnshaw, Chemistry of the Elements, Butterworth-

Heinemann. 5. S. Prakash, G.D. Tuli, S.K. Basu, and R.D. Madan, Advanced Inorganic Chemistry,

Vol. 1 & 2, S. Chand & Co. Ltd., New Delhi.

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Course Code: CHEM 2204 Quantitative Inorganic Practical-II


1. Precipitation titrations: (i) Determination of the strength of a silver nitrate solution by Mohr’s method. (ii) Determination of chloride by Volhard’s method. 2. Complexometric titrations using EDTA: (i) Determination of zinc by direct titration using Eriochrome-Black T as indicator. (ii) Determination of nickel by direct titration using murexide as indicator. (iii)Determination of calcium by substitution titration using Eriochrome-Black T as

indicator. (iv) Determination of aluminum by back titration using Eriochrome-Black T as

indicator. 3. Gravimetric analysis: (i) Determination of lead as lead chromate. (ii) Determination of sulfate as barium sulfate. (iii) Determination iron as Fe2O3. (iv) Quantitative separation and estimation of copper volumetrically and nickel

gravimetrically. (vii) Determination of Ca2+ and Mg2+ in a mixture. Books Recommended:

1. G.H. Jeffery, J. Bassett, J. Mendham and R.C. Denney: Vogel’s Quantitative Chemical Analysis, Longman Scientific & Technical, New York.


Delhi. 4. K. Kundu, Practical Inorganic Chemistry (in Bangla), Bangla Academy.

Course Code: CHEM 2205 Organic Chemistry IV (Biomolecules)


1. Carbohydrates: Definition, Classification, Constitution and configuration of monosaccharides, Ring structure or monosaccharides and their conformations, Synthesis of monosaccharides, Action of acids and bases in reducing sugars, Epimers, Anomers and anomeric configurations, Structure, Properties and reactions of mono-, di-, tri-saccharides, Polysaccharides: Definition, Constitution and Classification, Importance of Polysaccharides, Isolation of Polysaccharides and their purification using different physical and chemical methods, Structure elucidation of polysaccharides using chemical and spectroscopic methods, A introduction of some

32

important polysaccharides such as starch, cellulose, pectin, alginic acid, chitin, chitosan, glycogen, heparin and darmatan sulphates.

2. Amino acids, Peptides and Proteins: Definition, sources, classification and importance of amino acids, its buffer action in biological system, Structure, configuration, preparation and reactions of amino acids, Biosynthesis of amino acids, Peptides, its occurrence, constituents and geometry, C- and N-terminal residues of peptides, Proteins, their classifications and functions, Denatured and conjugated proteins.

3. Lipids: Definition, occurrence, classification and function, Composition of fats and oils, Hydrolysis of fats, Saturated and unsaturated fatty acids, Phosphoglycerides, Phosphate esters, Phospholipids and cell membranes, Biosynthesis of lipids.

4. Nucleic Acids: Definition, sources, and importance, Structure of nucleic acids, Nucleosides and nucleotides, DNA and RNA.

5. Purine: Chemistry of purines, purine acid; purine derivatives and xanthanes bases.

6. Glycoconjugates: A brief introduction of glycoprotein, proteoglycan and glycolipid.

Books Recommended:




Chemistry, Macmillan Pub. Co. 6. W.H. Brown and C.S. Foote, Organic Chemistry, Saunders College Pub. 7. R.W. Griffin Jr., Modern Organic Chemistry, McGraw Hill. 8. Guthrie and Honeyman, An Introduction to Carbohydrate Chemistry, Oxford

University Press. 9. O.P. Agarwal, Chemistry of Organic Natural Products, Vol-I & II, Goel Publishing.

Course Code: CHEM 2206 Analytical Chemistry


1. Errors, Sampling and Quantitative analysis: Accuracy, Precision, Mean, Average and standard deviation, Reliability of results, Confidence intervals, Comparison of results, Classification of errors, Source of errors, Minimization of errors, Determination of the accuracy of methods of quantitative analysis, Significant figures and computations, Statistical treatment of analytical data, Sampling procedures, Sample population, Significance of representative sampling, Working curve, Blank solution, Standard-addition technique, Curve fitting.

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2. Volumetric Analysis: Classification of reactions in titrimetric analysis; Molarity volumetric calculation; Normality volumetric analysis; Titer.

(a) Acid-base Titration: Neutralization indicators, Neutralization curve: neutralization of a strong acid with a strong base, neutralization of a weak acid with a strong base, neutralization of a strong acid with a weak base, neutralization of a weak acid with a weak base, neutralization of a polyprotic acids with strong base, Choice of indicators in neutralization reactions; Titration in non-aqueous solvents, Indicators for non-aqueous titration. (b) Complexation Titration: Principles, Metal titrants, Titration curve, Types of EDTA titration, Titration of mixtures, selectivity, masking and demasking agents, Metal ion indicators, Dithizone and diethyldithiocarbamate.

(c) Oxidation-reduction titration: Titration curve, Change of the electrode potential during the titration of a reductant with an oxidant, Detection of end point in oxidation-reduction titrations, Precipitation reactions and titrations, Effect of acidity on solubility of precipitates, Determination of end points in precipitation titration.

3. Gravimetric Analysis: Precipitation method, The colloidal state, Supersaturation and precipitate formation, The purity of the precipitate: co-precipitation, Conditions of precipitation, Washing the precipitate, Thermogravimetric method of analysis, TGA, DTA, DSC, & DTG analysis of a typical sample.

4. Atomic Spectrometric Methods: Emission spectroscopy, Flame emission spectrometry, Plasma emission spectrometry, Distribution between ground and excited state, Basic principles of atomic absorption spectroscopy and its application, Internal standard and standard addition calibration.

5. Colorimetric and Spectrophotometric Methods: Principles of colorimetric and Spectrophotometric methods, Beer’s law, Lambert law, Combined Beer-Lambert law and its application in UV-Vis spectroscopy, Deviations of Beer-Lambert law, Determination of pH of a solution by colorimetric methods, Determination of pK value of an indicator by spectroscopic method, Spectrophotometric titration, Apparatus for Spectrophotometric titration, Determination of equilibrium constant by spectrophotometry and determination of Pb & As.

6. Polarographic Analysis: Current voltage relationship, Mass transport processes, Direct current polarography (DC), Diffusion current, Charging current, Principles, advantages and applications over DC polarography, Cyclic voltametry: ASV, CSV.

7. Ion-exchange Methods: Principles, Types, Action of ion exchange resins, Ion-exchange equilibria, Factors determining the distribution of ions between ion exchange resins and solution, Ion exchange capacity, The column separation: experimental techniques, Some widely used resins, Ion exchange in organic and aqueous-organic solvents, Separation of amino acids, Effect of complexing agent, Separation of metal ions on anion exchange columns.

8. Solvent Extraction: Distribution coefficient, Distribution ratio, Factors favoring

solvent extraction, Quantitative treatment of solvent extraction equilibria, Synergistic

34

extraction, Ion association complexes, Extraction reagents, Solvent extraction of metals.

9. Chromatographic Methods: Chromatographic behavior of solutes, Retention

behavior, Partition coefficient, Column efficiency and resolution, Principles of paper chromatography (PC), thin layer chromatography (TLC), gas-liquid chromatography (GLC), liquid chromatography(LC), high performance liquid chromatography (HPLC), Column chromatography: general discussion, technique and some applications: separation of Ni, Cu, Co and Zn from a mixture and RF values by TLC, Separation of Fe and Al by column chromatography using cellulose.

Books Recommended:

1. G.D. Christian, Analytical chemistry, John Wiley & Sons. 2. Braun, Introduction to chemical analysis, McGraw Hill International. 3. Ewing, Instrumental methods of chemical analysis, McGraw-Hill International. 4. G.H. Jeffery, J. Bassett, J. Mendham and R.C. Denney: Vogel’s Quatitative Chemical

Analysis, Longman Scientific & Technical, New York. 5. Pecsok and Shields, Modern Methods of Chemical Analysis, John Wiley & Sons. 6. D.A. Skoog & D.M. West, Fundamental of Analytical Chemistry, Saunders

Publishing. 7. F.W. Fifield & D. Kealey, Principles & Practice of Analytical Chemistry, Wiley-

Blackwell. 8. R. Stock and C.B.F. Rice, Chromatographic Methods, Chapman and Hall.

Course Code: CHEM 2207 Nuclear and Radiation Chemistry


1. Introduction: Basic Concepts of Nuclear, Radiochemistry and Radiation Chemistry, Definition and scope of nuclear chemistry; Modern ideas in nuclear science and technology.

2. Atomic Nucleus: (i) Composition, (ii) Size, (iii) Density, (iv) Mass and Energy

correlation, (v) Nuclear binding energy, (vi) Stable and unstable nuclei, (vii) Factors responsible for the stability of a nucleus.

3. Modes of Decay: Radioactivity, (i) Laws governing radioactive decay, (ii) Half-life

and average life, (iii) Successive decay and branching decay, (iv) Radioactive equilibria.

4. Nuclear Reaction: (i) Basic concepts, (ii) Potential barrier, (iii) Elastic and inelastic

scattering, (iv) Q-value and threshold energy for nuclear reaction, (v) Reaction cross section, (vi) Excitation function, (vii) Reaction mechanism at low and high energy.

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5. Types of Nuclear Reaction: (i) Radiative capture, (ii) Photonuclear reaction, (iii) Reaction mechanism of low and high energy, Special reaction: (i) Evaporation, (ii) Spallation, (iii) Fission, (iv) Fusion, (v) Fragmentation, (vi) Transfer reaction.

6. Nuclear Fission: The process of nuclear fission, Fission Fragment and their mass

distribution, Fission energy, Fission cross section and thresholds, Fission Neutrons, Theory of nuclear fission.

7. Nuclear Fusion and Nuclear Reactor: Basic principle, The natural uranium reactor, The four factor formula, The classification of reactors, Reactor power, Critical size of thermal reactor; The Breeder reactor; Nuclear waste management; Nature’s nuclear reactor.

8. Interaction of radiation with Matter: Interactions of charged particles with matters and energy loss mechanism, Interaction of gamma radiation with matters, Photoelectric and Compton effects and pair production, Radiolysis of water spur reaction.

9. Radiation detection: Ionization current measurement, Ionization chamber,

Multificative ion-collection, G.M. counter, Scintillation counter: operation principles of NaI (T1) Scintillation detector, Proportional counter, Semiconductor gamma radiation detector-Ge (Li) and Hyperpure Germanium, Health physics instruments, Radio isotopes and their uses: Production and separation of radio isotopes, The Szilard – Shalmers reaction, Isotope dilution analysis, Activation analysis, Tracer technique for reaction kinetics and for industrial, agriculture and medical uses.

10. Nuclear and Radiomechanical Analytical Techniques: (i) Neutron activation

analysis, (ii) Isotope, isotope dilution analysis, (iii) Radiomechanical tracer techniques, Production of radioisotopes and labeled compounds, Radiation protection.

11. Radiation Protection: (i) External and internal radiation sources, (ii) Radiation

effects, (iii) Safety recommendation and regulations.

Books Recommended

1. Friedlander, Kennedy and Miller, Introduction to Nuclear and Radiochemistry, John Wiley & Sons, New York.

2. H.J. Arnikar, Essential of Nuclear Chemistry, Wiley Eastern Limited, New Age International Limited, 1995.

3. L. Yaffe, Nuclear Chemistry, Volume 1 & 2, Academic Press. 4. B.G. Harvey, Nuclear Chemistry, Prentice-Hall, Inc. Englewood Cliffs, N.J.

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Course Code: CHEM 2208 Physics Practical II


1. Determination of the end correction of a meter bridge and hence to determine the

specific resistance of a wire.

2. Determination of the value of an unknown resistance by a post office box.

3. Determination of the resistance of a galvanometer by half deflection method.

4. Verification of the Ohm’s law by using a tangent galvanometer.

5. Determination of the refractive index of glass of a prism by spectrometer.

6. Determination of the radius of curvature of a plane-convex lens and wavelength of

light by Newton’s ring method.

7. Study of the variation of capacitive and inductive reactance with frequency.

8. Investigation of the properties of a series resonance circuit. Books Recommended:

1. C.L. Arora: B.Sc. Practical Physics, S. Chand & Co. Ltd. 2. Giasuddin and Shahabuddin: B.Sc. Practical Physics (3rd ed.), Hafiz Book 3. Center, Dhaka. 4. Harnam Singh: B.Sc. Practical Physics, S. Chand & Co. Ltd.

Course Code: CHEM 2209 Statistics and Numerical Methods


SECTION A (Statistics): 1. Definition and scope of the study of statistics; Nature of statistical data; Attributes

and variables; Population and sample; Collection and condensation of data; Frequency distribution; Graphical representation of data.

2. Mean and standard deviation; Variance, Coefficient of variation; Errors; Distribution

of random errors. 3. Correlation and Regression: Bivariate data, Relationship between the variables, Distribution and use of coefficient of correlation, Correlation and regression

coefficients, Linear correlation, Partial and multiple correlation, Rank correlation and correlation ratio.

37

SECTION B (Numerical Methods): 1. Polynomial interpolation. 2. Numerical integration. 3. Systems of Linear Equations: Gaussian elimination method, The least square method. 4. Solution of ordinary differential equation by Euler methods, The Runge-Kutta methods. Books Recommended:

1. E. Steiner, The Chemistry Math Book, Oxford University Press. 2. S. Lang, Introduction to Linear Algebra, Springer. 3. R. R. Stoll, Linear Algebra and Matrix Theory, McGraw-Hill. 4. R. L. Burden and J. D. Faires, Numerical Analysis, Brooks Cole. 5. M. Nurul Islam, An Introduction to Statistics and Probability, Mollick Brothers.

38

Course Code: CHEM 3101 Chemical Kinetics


1. Chemical Kinetics: Review of elementary concepts: order, molecularity, rate law and rate constant, Types of order, Methods for determination of order and rate constants, elementary and complex reaction.

2. Accounting for the Rate Law: Variation of concentration with time, Rate

determining step, Steady-state approximation, Kinetics of isotope effect, Unimolecular reactions: Lindemann- Hinshelwood mechanism, Activation energy of composite reactions, Experimental techniques: classical techniques, discharge flow, resonance fluorescence, Laser induced fluorescence, Liquid and stopped-flow system, Flash photolysis, Shock tubes, Relative rate determination.

3. Techniques and Methods for Measuring Rates of Reactions: Conventional

chemical methods, Conductance methods, Polarimetry, Spectrophotometric methods, Methods based on gas pressure volume measurements, Techniques for measuring rates of fast reactions: production and measurement of free radicals, flash photolysis, flow methods, relaxation techniques, relative methods.

4. Molecular Reaction Dynamics: The collision theory of unimolecular and

bimolecular reactions; kinetic theory of termolecular reactions; theory of absolute reaction rate; Transition state theory for gas phase bimolecular reactions, Eyring equation, thermodynamic formulation of reaction rate, application; Activated complex theory & collision theories for reaction in solution, Diffusion-controlled reaction, effect of dielectric constant & pressure on the rate of reaction in solution, Primary salt effect, Kinetic isotope effect.

5. Mechanism on the basis of kinetic studies: Thermal decomposion of C2H6,

CH3CHO, CH3COCH3, O3, COCl2, hydrogen-bromine reaction and calculation of activation energy, solid state reaction: Tarnish reaction & Wagner theory, Thermal decomposition: mechanism, solid-solid reaction, Photographic process.

Books Recommended:

1. M.M. Huque and Y.A. Mollah, Principles of Physical Chemistry, Students’ Publications, Dhaka.

2. Samuel H. Maron and Carl F. Prutton, Principles of Physical Chemistry, Oxford & IBH Publishing Co. Pvt. Ltd, New Delhi.

3. W. J. Moore, Physical Chemistry, Prentice Hall Publication 4. P.W. Atkins, Physical Chemistry, W.H. Freeman & Co. 5. S. Glasstone and D. Kews, Elements of Physical Chemistry, Macmillan & Co. Ltd. 6. G.M. Barrow, Physical Chemistry, McGraw-Hill. 7. M.J. Pilling and P.W. Seakins, Reaction Kinetics, Oxford Science Publications. 8. K.J. Laidler, Chemical Kinetics, McGraw-Hill, New Delhi.

39

Course Code: CHEM 3102 Physical Chemistry Practical-IV


1. Determination of the kinetics of dissolution of magnesium metal in dilute HCl. 2. Determination the rate constant and order of a reaction between acetone and iodine in

presence of mineral acid and a catalyst. 3. Determination of the specific reaction rate of the hydrolysis of an ester by NaOH

solution (conductometric method). or,

Determination of the molecular weight of a substance by cryoscopic method. 4. Determination of the percentage of D-glucose and D-tartaric acid in a given solution

polarimetrically. 5. Spectroscopic analyses: (a) Determination of the absorption curve of a colored substance in solution and to

verify the validity of Beer’s law, (b) Determination of the strength of an unknown solution, (c) Determination of stability constant of a complex compound.

(d) Preparation of solution, calibration curve and interpretation of UV-Spectra (e) Instrument preparation, calibration and interpretation of IR-Spectra. (f) Determination of the concentration of K2Cr2O7 and KMnO4 in a solution or mixture by spectrophotometric method.

Books Recommended:

1. Palit, Practical Physical Chemistry, Science Book Agency, Calcutta 2. Sharma, Practical Physical Chemistry, Vikas Publishing House Pvt. Ltd. 3. J.B. Yadav, Advanced Practical Physical Chemistry, Goel Publishing House. 4. A. Findlay, Practical Physical Chemistry, Longmans, Green & Co. Ltd. 5. Khalique, A Text Book of Practical Chemistry, Ideal Library, Bangla Bazar, Dhaka. 6. O.P. Pandey, D.N. Bajpai, and S. Giri, Practical Chemistry, S. Chand & Co. Ltd, New

Delhi. 7. A. J. Mian and M.M. Hoque, Practical Chemistry, Student Publications, Dhaka.


Atomic Structure and Chemical Bonding (Advanced Concepts) (Full Marks: 20 + 10 + 70 = 100; 2 Credits)

1. Atomic Structure (Wave Mechanical Approach): de Broglie’s concept of dual

nature of matter: de Broglie wave equation, Experimental verification of wave nature of electrons, Confirmation of quantization of angular momentum (Bohr’s theory) by de Broglie’s concept, Heisenberg’s uncertainty principle, Nature of wave motion,

40

Schrödinger wave equation, Interpretation of the wave function: eigen value and eigen function, Solution of the wave equation, Schrödinger equation for hydrogen like atoms, Separation of variables, radial, angular and probability functions, Representation of symmetry of orbitals, General implications of quantum theory in chemistry.

2. Critical Studies of Different Bond Types and Theories:

(a) Ionic Bonds: Energetics of ionic bond formation, Inter- atomic distances and their relationship with the structures of compounds and crystals, Born-Haber cycle, Mandelung constant, Lattice energy and its significance, Sizes of ions: ionic radii and ionic structure, Radius ration effect, Packing of ions in crystals.

(b) Covalent Bonds:

(i) Valence Bond Theory (VBT): Sigma, pi and delta bonding, Lewis model, octet rule, expanded octet and limitations, Directional characteristics of covalent bonds: hybridization, shapes and molecules-VSEPR theory, Resonance, Isolibality.

(ii) Molecular Orbital Theory (MOT): Construction of molecular orbital by

LCAO method, Overlap criteria of bond formation: bonding, anti-bonding and nonbonding orbitals, Bond order, MOs representations of homo- and hetero-diatomic molecules, HOMO and LUMO, MOs of polyatomic molecules with �- and �-bonding-the ligand group orbital approach, Comparison of VBT with MOT, Mixing of molecular orbitals and their correlation diagrams.

3. Bonding in Metals and Alloys: Theory of metals, Valence bond approach, The band

theory of metals, Metallic properties, Solid solution, Super structure and intermetallic compounds, Nonstoichiometric compounds.

Books Recommended:

1. J. D. Lee, Concise Inorganic Chemistry, ELBS with Chapman & Hall, Croatia. 2. F.A. Cotton, G. Wilkinson, Advanced Inorganic Chemistry, Wiley-India. 3. S. Prakash, G.D. Tuli, S.K. Basu, and R.D. Madan, Advanced Inorganic Chemistry,

Vol. 1& 2, S. Chand & Co. Ltd., New Delhi. 4. K. Kundu, Atomic Structure and Periodic Table, Bangla Academy, Dhaka. 5. K. Kundu, Chemical Bonding and Shapes of Molecules, Bangla Academy, Dhaka. 6. J.E. Huheey, Keiter & Keiter, Inorganic Chemistry, 4th ed., Harper Collin College

Publishers 7. Manas Chandra, Atomic Structure and Chemical Bond including Molecular

Spectroscopy, Tata McGraw-Hill Publishing Co. Ltd. 8. G. L. Miessler & D. A. Tarr, Inorganic Chemistry, 3rd ed., Pearson, India. 9. Shriver & Atkins, Inorganic Chemistry, 4th ed., Oxford University Press, India. 10. C. E. Housecroft & A. G. Sharpe, Inorganic Chemistry, 3rd ed., Pearson.

41

Course Code: CHEM 3104 Chemical Spectroscopy


1. Introduction to Spectroscopy: Electromagnetic radiation, Characterization of Electromagnetic radiation, Quantization of energy, Absorption and emission of radiation, Regions of spectrum, Representation of spectra, Signal-to-noise, Resolving power, Width and intensity of spectral transitions.

2. Microwave (rotational) Spectroscopy: Rotation of molecules and their classification, Interaction of electromagnetic radiation with rotating molecule, Rotational energies of simple linear molecules, Rotational energy levels and selection rules, Rotational spectra and determination of bond length of diatomic molecules, Rotation of polyatomic molecules, Techniques and instrumentation, Microwave oven, Stark and isotope effect.

3. Infrared (vibrational) Spectroscopy: Introduction and principle, Vibration in molecule, Harmonic and inharmonic vibration in diatomic molecules, Vibration- rotation spectra of diatomic molecules, Breakdown of the Born-Oppenheimer approximation: interaction of rotations vibrations, Instrumentation, Vibrational spectra of polyatomic molecules.

4. Raman Spectroscopy: Quantum theory of Raman effect, Classical theory of Raman effect, Elementary treatment of Raman spectra, Pure rotational spectra and Vibrational Raman Spectra. Structure determination from Raman and infrared spectroscopy, Techniques and instrumentation, Polarization of light and Raman effect.

5. Electronic Absorption (UV-VIS) Spectrometry: Introduction, Spectra of hydrogen and hydrogen like element, Electronic angular momentum, The Zeeman effect, Electronic spectra of diatomic molecule, Vibrational coarse structures, Frank-Condon principle; Dissociation energy and dissociation products, Rotational fine structure of electronic-vibration transition, Diatomic molecular energies in different electronic arrangements, Electronic angular momentum, Electronic spectra and molecular structure, Technique and instrumentation UV-VIS spectrometry.

6. Magnetic Resonance Spectroscopy: Spin and an applied magnetic field, The energies of nuclei in magnetic fields, The chemical shifts, Pulse techniques in NMR, Electron spin resonance (ESR) spectroscopy: introduction, the position of ESR absorption, The G factor, hyperfine splitting, The fine structure of ESR, Double resonance in ESR, Techniques in ESR spectroscopy.

7. Solid State and Surface Spectroscopy: Principles of important techniques to investigate surfaces and the solid state (EELS, RAIRS, Raman Spectroscopy, Inelastic Helium Scattering, PES, AES, XRF and EXAFS etc.).

8. Mössbauer Spectroscopy: Basic Principle and Applications.

Books Recommended:

1. C. N. Banwell and E. M. McCash, Fundamentals of Molecular Spectroscopy, Tata McGraw-Hill, New Delhi.

2. G.M. Barrow, Introduction to Molecular Spectroscopy.

42

3. J. M. Hollas, Modern Spectroscopy, Wiley. 4. G. Chatwal and S. Anand, Spectroscopy (Atomic and Molecular). 5. P.S. Sindhu, Molecular Spectroscopy, Tata McGraw-Hill, New Delhi. 6. F.P. Larkins, Introduction to Spectroscopy. 7. R. Chang, Basic Principles of Spectroscopy, McGraw Hill. 8. D.H. Williams and I. Fleming, Spectroscopic Methods in Organic Chemistry, Tata

McGraw-Hill, New Delhi. 9. P. W. Atkins, Physical Chemistry, Oxford University Press.

Course Code: CHEM 3105 Identification of Organic Compounds (Practical)


1. Physical appearance. 2. Elemental analysis. 3. Solubility test. 4. Functional group analysis: By (a) chemical methods, (b) Spectroscopic methods.

(i) carboxylic acids, (ii) aldehydes and ketones, (iii) alcohols and phenols, (iv) esters, (v) amines, (vi) amides and substituted amides, (vii) nitro compounds (viii) nitriles, (ix) unsaturated compounds, (x) hydrocarbons, (xi) halogenated compounds, (xii) organo sulphur compounds.

5. Literature survey. 6. Determination of physical constants (m.p. and mixed m.p. determination). 7. Naming of the identified compounds. Books Recommended: 1. H.T. Clarke, B. Haynes, E.C. Brick, G.C. Shone, Hand Book of Organic Analysis,

Quantitative and Qualitative, Edward Arnold, 5th Edition. 2. R.L. Shriner, R.C. Fuson, and D.Y. Curtin, Systematic Identification of Organic

Compounds, John Wiley Sons, Inc, New York, London, Sydney. 3. H.D. Durst and G.W. Gokel, Experimental Organic Chemistry, McGraw-Hill Book

Company, New York, 1987. 4. B.S. Furniss Vogel’s Text Book of Practical Organic Chemistry, ELBS with

Longman, 5th Edition.

43

Course Code: CHEM 3106 Chemistry of Natural Products


1. Natural Products: Definition, occurrence and importance of some natural products, General methods of isolation, purification and determination of structure of natural products by chemical and spectroscopic methods.

2. Alkaloids: Occurrence, classification, extraction and purification of alkaloids,

General methods of determining structure, Chemistry of ephedrine, atropine and cocaine, Biosynthesis of alkaloids.

3. Terpenoids: The essential oils, Classification of terpenes, Isoprene rule, Isolation and

purification, General methods of determining structures of terpenes, Detailed studies of some monoterpenes, (i) acyclic monoterpenes: myrcene, citral, (ii) monocyclic monoterpenes like limonene, (iii) bicyclic monoterpenes like �-pinene, camphor, Biosynthesis of monoterpenes.

4. Steroids and Hormones: Introduction of steroids and hormones, Nomenclature and

functions of steroids and hormones, Cholesterol and its effect in biological systems, Steroidal hormones and glycoisides, Natural and synthetic hormones.

5. Flavonoids: Anthocyanins, flavones, xanthenes and other derivatives. Naturally

occurring coloured compounds: chlorophyll and haemoglobin. 6. Pheromones: Pheromones, Their stereo-specificity and action in biological systems. 7. Antibiotics: Chemistry of penicillin and chloramphenicol.

Books Recommended:

1. I.L. Finar, Organic Chemistry, Vol. 1 & 2, Longmans, Green & Co. 2. K.B.G. Torssell, Natural Product Chemistry, John Wiley and Sons, New York. 3. G.A. Wawan, An Introduction to the Alkaloids, Blackwell. 4. P. de Mayo, Mono & Sesqui-terpenes, Inter Science. 5. S.W. Pettetier, Chemistry of the Alkaloids, von Nostrand Renihold. 6. Fleming, Selected Organic Synthesis, John Wiley and Sons, New York. 7. P.S. Kalsi, Natural Product Chemistry, Kalyani Publishers, New Delhi. 8. O. P. Agarwal, Chemistry of Organic Natural Products, Vol I & II, Goel Publishing

House.

44

Course Code: CHEM 3107 Fundamentals of Pharmaceutical Chemistry


1. Introduction: Pharmaceutical process: raw material, classification, testing, procurement, Importance of pharmaceutical chemicals and processing of pharmaceutical products, equipments.

2. Pharmacopeia: Introduction, BP, USP, EUP, INN. 2. Pharmaceutical Analysis: Principles underlying qualitative and quantitative

pharmaceutical analysis, Significance of qualitative analysis in pharmaceutical quality assurance and quality control, Theory and Basic concepts of GMP, ISO 9000, ISO 9001, TQM, (a) Titrametric Analysis: Acid base titration in pharmaceutical analysis, Redox titration: iodometry and iodimetry, Application in pharmaceutical analysis, (b) Non aqueous titration: principles and application, (c) Instrumental analysis: UV, IR, HPLC; Application in drug analysis, (e) Microbiological assay: principle and applications (specific examples), Sterility and pyrogen Testing.

3. Unit Process and Unit Operation in Pharmaceutical Chemistry: Design,

construction and safety measures of pharmaceutical manufacturing plant; Principles involved and technique employed in drying, granulation, mixing, and clarification; Filtration, milling distillation, control of humidity, refrigeration, air conditioning, piping and stages, GMP and GMT.

4. Pharmaceutics:

(a) Tablet: Definition, formulation and compounding; Wet and dry granulation methods, Slugging and capping of tablets, Coating of tablets, Disintegration test for compressed tablets, Essential qualities of good tablets. (b) Capsule: Materials for production of hard gelatin capsules, Methods of capsule filling, Importance evaluation of capsules. (c) Ointments: Definition and classification, Factors affecting skin absorption, Ointments bases, Preparation of ointments including dermatological preparation. (d) Parenteral Products: Definition and types of parenteral products, Vehicles for parenteral products, Cleaning equipments and preparation of parenteral products including clarification, Filling, sterilization, sealing and capping, Control requirements for paranteral products, Pyrogen tests, Sterility test, Foreign particles, Inspection for leakage, Identity, labeling, storage, Administration of parenteral products.

(e) Emulsions and Aerosols: Definition and classification, Theory of emulsions, Emulsifications and emulsifying agents, Types of emulsifying agents, Sedimentation testing, Preparing equipments, Packing and storage, (b) Internal and External Liquid:

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Preparations of different types of Syrups, Elixirs, Compounding of internal and external liquids, Liquids manufacturing; The hydrophilic and lyophilic system.

Books Recommended: 1. E.W. Martin, Husa’s Pharmaceutical Dispensing, Mack Publishing. Co. 2. A. Burger, Medicinal Chemistry and Drug Discovery, Wiley-Interscience. 3. A.I. Vogel, A Text Book of Practical Organic Chemistry, Prentice Hall. 4. Curtin, Shriner and Fusion, Systematic Organic Analysis, Wiley. 5. B.G. Katzsung, Basic and Clinical pharmacology, 9 th edition, McGraw-Hill, New

York. 6. L. Lachman, The Theory and Practice of Industrial Pharmacy, 3 rd Indian edition.

Varghese Publishing House, Bombay. 7. W.O. Foye, Principles of Medicinal Chemistry, 3 rd edition, Varghese Publishing

House, Bombay. 8. A. White, P. Handler and E. L. Smith, Principles of Biochemistry, McGraw-Hill. 9. M. Mesbahuddin and M. R. Islam, General Principles of Pharmacology, Bengal

Library, Dhaka.

Course Code: CHEM 3108 Pharmaceutical Chemistry Practical and Field Visit

(Full Marks: 20 + 10 + 70 = 100; 1+1 = 2 Credits)

1. Analysis of different raw materials and pharmaceutical products, e.g. assay of vitamin-C and assay of aspirin in tablets etc.

2. Pharmaceutical Industries visit would be carried out and submission of tour report.

Course Code: CHEM 3109 Microbiology


Introduction of microbiology: 1. Important genera and group. Nature and function of beneficial and harmful bacteria. 2. Role of microorganism in biodegradation of organic compounds. 3. Pathogenic and non-pathogenic bacteria, Toxin produced during food poisoning and

outbreak, Sources of pathogenic bacteria for food contamination and prevention method.

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Control of Microorganism: 1. General principle of microbial control, heat treatment, cold treatment, dehydration,

radiation, filtration; Factors important in the control of microorganisms. 2. Practical uses of sterilization, disaffection and bacteriastasis, commonly used

chemical disinfectants and other anti-microbial agents in food science. 3. Hygene and Sanitation. 4. Basic principles of microbiological treatment: An aspect of waste water treatment. Books Recommended: 1. G.J. Tortora, B.R. Funke and C.L. Case, Microbiology: An Introduction, 8th ed.,

Pearson Education Inc., Singapore. 2. M.J. Peiczar Jr., E.C.S. Chan and N.R. Krieg., Microbiology,. 5th ed, Tata McGraw-

Hill Publishing Co. Ltd., New Delhi, India. 3. G. Bitton, Wastewater Microbiology. Wiley-Liss, Inc., USA. 4. R.A. Herbert and G.A. Codd, Microbes in Extreme Environment, Academic Press

Inc.

47

Course Code: CHEM 3201 Transition Metals and Coordination Chemistry

(Full Marks: 20 + 10 + 70 = 100; 3 Credits) 1. Transition Elements: General characteristics, Shape and function of d-orbitals, Magnetism in transition metal chemistry: origin of paramagnetism, diamagnetism, Ferromagnetism and antiferromagnetism, Magnetic susceptibility, Curie law.

2. Elements of Coordination Chemistry: Definition and scope of coordination chemistry, Coordination compounds, ligands and their types, coordination number; nomenclature of coordination compounds, Classification of coordination compounds, Nomenclature of coordination compounds, Structural theories of complex compounds: Blomstrand and Jorgensen’s chain theory, Werner’s theory, Sidgwick’s electronic interpretation: primary and secondary valencies, EAN of metals, Pauling’s valence bond theory and its limitations, Isomerism stereochemistry of 4- and 6-coordinated complexes, Chelate complexes, Stabilization of unusual oxidation states by complexation, Application of coordination compounds.

3. Concepts of Modern Bonding in Coordination Compounds: The crystal field

theory and ligand field theory for octahedral and tetrahedral complexes, Crystal field stabilization energy, Effects of crystal field splitting, Consequences of ligand field splitting: magnetic properties, electronic properties, spectrochemical series, Structural and thermodynamic effect of ligand field splitting, Tetragonal distortion of octahedral complexes: Jahn-Teller distortion, Square planner complexes, Tetrahedral complexes, Molecular orbital theory.

4. Stability of complexes: Factors influencing the stability of complexes, Stability

constant, Effect of ligand on the stability of complexes, Measurement of Stability constant.

5. Reaction Mechanism of Coordination Complexes: Inert and labile complexes, (i)

Ligand substitution reactions: substitution in square-planar complexes, the trans effect, its application and mechanism, substitution in octahedral complexes, (ii) Redox reaction: inner-sphere and outer-sphere mechanism.

6. Complexes of �-acid Ligand: Structure, preparation, bonding and properties of

metal carbonyls, phosphine and phosphorus trihalides, �-acid complexes of nitrogen, metal nitrosyls, �-acid complexes of unsaturated hydrocarbons, �-allyl and �-aromatic complexes.

Books Recommended:

1. F.A. Cotton, G. Wilkinson and P.L. Gaus, Basic Inorganic Chemistry, Wiley-India. 2. F.A. Cotton, G. Wilkinson and P.L. Gaus, Advanced Inorganic Chemistry, Wiley-

India. 3. S. Prakash, G.D. Tuli, S.K. Basu, and R.D. Madan, Advanced Inorganic Chemistry,

Vol. 2, S. Chand & Co. Ltd., New Delhi.

48

4. J. Huheey, Keiter & Keiter, Inorganic Chemistry: Principles of Structure and Reactivity, 4th ed., Prentice Hall, India.

5. G. L. Miessler & D. A. Tarr, Inorganic Chemistry, 3rd ed., Pearson, India. 6. Shriver & Atkins, Inorganic Chemistry, 4th ed., Oxford University Press, India. 7. C. E. Housecroft & A. G. Sharpe, Inorganic Chemistry, 3rd ed., Pearson. 8. K. Kundu, Coordination Chemistry, Bangla Academy, Dhaka (Language of the book

is in Bengali).


Inorganic Synthesis Practical (Full Marks: 20 + 10 + 70 = 100; 2 Credits)

1. Preparation of sodium thiosulphate.

2. Preparation of ammonium nickel(II) sulphate.

3. Preparation of tris(thiourea)copper (I) sulfate.

4. Preparation of cis- and trans-potassium dioxalatodiaquachromate(III).

5. Preparation of tris(acetylacetonato)manganese(III) and comparison of its IR spectra with that of the ligand.

6. Preparation of Al3+ and Cu2+ complexes with acetylacetone and comparison by IR spectra.

7. Synthesis of NaCl crystals by common ion effect and investigating the crystals by X-

ray diffraction. Determination of the percentage of sodium by ion exchange method.

8. Preparation of FeSO4. 7H2O. Comparing its masses in an ordinary and Gouy balance.

Quantitative estimation of the components including the moisture content and the

presence of Fe3+ ion as impurity.

9. Preparation of CuSO4.5H2O starting from copper and investigating its infrared

spectrum and thermal dehydration pattern. Interpreting the reactivity of copper and

iron towards sulfuric acids.

10. Synthesis of [Cu(NH3)4]SO4.H2O from CuSO4.5H2O Books Recommended:

1. Zvi Szfran, Ronald M. Pike, and Mono M S, Microscale Inorganic Chemistry, John Wiley & Sons, New York.

2. Gilbert, Alyea, Dutton, and Dersisbach, Tested Demonstration in Chemistry 1-2, Division of Chemical Education, American Chemical Society.

3 G.H. Jeffery, J. Bassett, J. Mendham, and R.C. Denny, Vogel’s Textbook of Quantitative Chemical Analysis, Longman and ELBS.

49

4. G. Pass and H. Sutcliffe, Practical Inorganic Chemistry, Preparations, Reactions and Instrumental Methods, Chapman and Hall, New York.

5. J.D. Woollins, Inorganic Experiments, VCH Verlagsgesellschaft mbh, Weinheim. 6. K. Kundu, Practical Inorganic Chemistry, Bangla Academy, Dhaka.

Course Code: CHEM 3203 Organic Reaction Mechanism


1. Methods of Determining Reaction Mechanisms: Classes of organic reaction mechanisms, Methods of determining reaction mechanisms : Meaning of reaction mechanism, Energy profile, Identification of products, Possible intermediates and their trapping, Isotopic labelling, Stereochemical studies, Detection of intermediates; Kinetic study and stereochemical evidence.

2. Substitution Reactions: Nucleophilic substitution reaction in aliphatic system,

Duality of mechanism. SN1 and SN2 reaction mechanism, Factors affecting the mechanism of substitution reaction. Aromatic substitution both nucleophilic and electrophilic, Stereochemistry. Neighboring group participation.

3. Addition Reactions: Mechanism of addition to >C = C<, >C = O bonds: conjugated

system like conjugative diene and conjugated unsaturated carbonyl compounds, their stereochemistry, Kinetics, Hydration of olefins, Addition of hydrogen halides, Peroxide initiated addition of hydrogen bromide, Addition of halogens, Diels-Alder reaction, Grignard reagents. Canizzaro reaction.

4. Elimination Reactions: Elimination -inlight of addition and substitution; E1, E2 and

E1cB mechanisms. Orientation in elimination reactions, Competition between elimination and substitution, Intramolecular (cis) elimination, Factors affecting the elimination reaction.

5. Polymeriztion Reactions: Free radical, Cationic and anionic polymerization

reactions, Addition and condensation polymerizations, Epoxy resins formation. 6. Mechanism of Some Important Reactions: Wolf-Kishner reduction, Clemmensen

reduction, Meerwein-Ponndorf-Verley reduction, Oppenauer oxidation, Reimer- Tiemann reaction. Kneovengel reaction. Aldol Condensations, Perkin reaction. Benzoin condensation, Wittig reaction, Michael and Mannich reactions with all mechanistic details, Reduction with metal hydrides: LiAlH4, NaBH4.

Books Recommended: 1. Peter Sykes, A Guidebook to Mechanism in Organic Chemistry, Orient Longman. 2. Breslow, Organic Reaction Mechanism, Benjamin/Cummings Co.

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3. Jerry March, Advanced Organic Chemistry, Reactions, Mechanisms and Structures, McGraw-Hill.

4. T.H. Lowry and K. S. Richardson, Mechanism and Theory in Organic Chemistry, Harper Collins Publishers, Inc., New York.

5. C.K. Ingold, Structure and Mechanism in Organic Chemistry, Bell.

Course Code: CHEM 3204 Chromatographic Separation Practical


1. Separation of organic compounds by chromatographic methods:

(a) Preparation of thin layer plates.

(b) Separation of mixture of colored compounds by TLC.

(c) Separation of colored compounds by column chromatography using alumina and

silica-gel as stationary phases.

(d) Identification of free sugars by paper chromatography and detection of the

separated compounds by dipping and spray reagents.

2. Studies of some organic reactions.

Books Recommended:

1. A. I. Vogel, A text book Organic Quantitative Analysis Part II, ELBS.

2. Chromatography: Published by IFS and ICAT

Course Code: CHEM 3205 Stereochemistry

(Full Marks: 20 + 10 + 70 = 100; 3 Credits) 1. Fundamentals of Stereochemistry: Stereochemistry and stereoisomerism. 2. Optical Activity and Optical Isomerism: Optical isomerism due to asymmetric

carbon atoms, Asymmetric synthesis, Stereoisomerism, Chirality, Prochirality, Pseudo Chirality, Optical activity, Specific rotations, Enantiomerism, Diastereoisomerism, Epimers, Anomers, Meso compounds, Racemic modification.

3. Geometrical Isomerism: Conditions; Configurations of geometrical isomers: cis-

trans, E/Z system, Syn-anti, Physical properties and configurational assignment of geometrical isomers, Geometrical isomerism of polyenes, carbon-nitrogen, nitrogen-nitrogen double bonds and cyclic compounds.

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4. Configuration: D & L, threo erythro, R & S configurations, Absolute and relative configuration and their correlation.

5. Stereochemistry of Fused Ring System: Stereochemistry of decalines, Perhydroanthrancene, Perhydrophenanthrene, their optical activity and their relative stability, Fused rings and bridged-ring systems; Bredt’s rule and its exceptions in flexible ring systems.

6. Conformations: Conformation and conformers, Conformation of propane, butane,

ethanediol, dihydroxystyrene, dichlorostyrene, their physical properties and stability. 7. Conformational Analysis: Conformation and their physical properties,

Conformational effects on stability and reactivity in diastereoisomers and in individual compounds, Conformational effects in small, medium and large ring systems.

8. Optical Rotation and Rotatory Power: Factors leading to chirality, Molecular

dissymmetry, Atomic dissymmetry and conformational asymmetry, Circular bifringence and circular dichroism (CD), Cotton effect, Dependence of optical rotation on wavelength-optical rotatory dispersion (ORD).

9. Chiral and Prochiral Molecules, Pro-R, Pro-S, Homotopic and Heterotopic ligands

and faces, Enantiotropic ligands (HCN addition), Diastereotropic ligands and faces, Enzymatic oxidation-reduction, Prostereoisomerism in biochemical reactions (citric acid cycle), Stereochemistry of molecule synthesize reaction.

10. Configuration and conformation of cyclic compounds, Three, four, six-membered

ring conformation analysis and di- and poly-substituted cyclohexanes. Books Recommended:




Chemistry, Macmillan Pub. Co. 6. W.H. Brown and C.S. Foote, Organic Chemistry, Saunders College Pub. 7. R.W. Griffin Jr., Modern Organic Chemistry, McGraw Hill. 8. I.L. Eliel: Stereochemistry of Carbon Compounds, Tata McGraw-Hill 9. Mislow, Introduction to Stereochemistry, Benjamin. 10. P. S. Kalsi, Stereochemistry, Conformation and Mechanism, Wiley Eastern Ltd.

52

Course Code: CHEM 3206 Industrial Chemistry


1. Textiles: Classification, Difference between natural and synthetic fibers, Properties of fibers, Manufacture of synthetic fibres, Viscose rayon, Cuprammonium rayon, Acetate rayon, Nylons, Polyesters, Dacron, Natural fibers (cotton, silk, wool).

2. Fertilizer Industries: Definition, Plant nutrients and their functions, Role of fertilizer

in agriculture, Manufacture of ammonium nitrate, calcium phosphate, ammonium phosphate, normal super phosphate (NSP), triple super phosphate (TSP), potassium compounds, Manufacture of urea from natural gas, mixed fertilizer, Fertilizer industries in Bangladesh.

3. Sugar and Fermentation Industries: Manufacture of cane sugar, Refining of raw sugar, Production of sugar from sugar Beet, Milling operation and control of evaporation, Vacuum pen and centrifugal, Seeding or graining, Utilization of by products, Sugar industry in Bangladesh.

4. Glass and Ceramic Industry: Definition, Types of ceramic products, Basic raw materials, White wares, Manufactures of porcelain, Chemical conversion including basic ceramic industry, Heavy clay products, Manufacture of refractory, enamels, Ceramic industries in Bangladesh, Definition of glass, Classification of glass, Physical and Chemical properties of glass, Raw materials, Manufacturing methods of glass, Some special glass and their properties, Refractory’s. Heavy clay product.

5. Cement Industry: Raw materials, Portland cement manufacture, Types of Portland cement, Theory of setting and hardening of cement, Different types of cement, Characteristic of good cement, Testing of cement, Cement factory in Bangladesh,

6. Pulp, Paper and Rayon Industries: Natural source of cellulose, Different process for the manufacture of pulp, Recovery of chemicals from waste cooking liquor, Manufacture of paper board, rayon, cellulose acetate and cellulose nitrate, Pulp and paper industries in Bangladesh.

7. Paints and Varnishes: Constituents of paints, varnishes, lacquers and enamels and their functions, Factors influencing satisfactory performance of surface coating, Properties of pigments, Manufacture of paints and varnish, Difference between paints and varnishes.

8. Soaps and Detergents: Raw materials, Fat splitting, Manufacturing of laundry and toilet soaps, Recovery and refining of glycerin, Composition of different types of soaps. Detergents: definition, classification and their manufacture, Builders, Additives, Biodegradability of detergents, Comparison of soap and detergents, cleaning action of soap and detergent.

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9. Petroleum Industry: Definition, origin, composition and classification, Refining and distillation of petroleum, Cracking of petroleum, Motor and aviation fuels, Natural gasoline, Aviation gasoline, Octane number, Cetane number, Production of high octane, Alkylation, Polymerization, Isomerization and reforming.

10. Metallurgy: Ores processing, Forth flotation, Sorting, Classification, Calcining, Roasting, Pig iron (raw materials, manufacture, bi-product, heat recovery), Steel making (the Bassemer and Open-heart process, electric furnace process), Vacuum treatment of steel, Effect of impurities on steel, Stainless steel.

Books Recommended: 1. R.N. Shreve, The Chemical Process Industries, Mc-Graw Hill. International Book

Company. 2. B.K. Sharma, Industrial Chemistry- Including Chemical Engineering, Goel

Publishing House, Meerut. 3. E.R. Riegel, Industrial Chemistry, Reinhold Publishing Co. 4. O.P. Aggarwal, Engineering Chemistry, Khanna Publishers, Nai Sarak, Delhi. 5. G. Martin, Industrial and Manufacturing Chemistry, Vol. I & II.� 6. B.N Chokraborty, Industrial Chemistry,�Oxford and IBH Publishing Co. (P) Ltd. New

Delhi. 7. A.S.M.N.H. Bhyiyan, Industrial Chemistry and Chemical Technology, Dhaka

University Press. 8. A.R. Bailey, A Textbook of Metallurgy,�MacMillan & Co. 9. R.K. Das, Industrial Chemistry (Part I & II), Kalyani. Publishers, New Delhi.

Course Code: CHEM 3207 Industrial Chemistry Practical and Field Visit

(Full Marks: 20 + 10 + 70 = 100; 1 + 1 = 2 Credits)

1. Analysis of different raw materials and products. 2. Industrial tour would be carried out and submission of tour report. Books Recommended:

1. E.R. Riegel and J.A. Kent, Riegels’ Handbook of Industrial Chemistry, Kluwer Academic / Plenum Publishers.

2. Liegue, Engineering Materials. 3. G. Martins, Industrial and Manufacturing Chemistry (Vol. I, II & III). 4. R. K. Das, Industrial Chemistry (Part I & II), Kalyani. Publishers, New Delhi. 5. Kirk-Othmer Encyclopedia of Chemical Technology, John Wiley & Sons.

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Course Code: CHEM 3208 Biochemistry


1. Biochemical Aspects of Enzymes: Characterization and classification, Coenzyme and prosthetic group, Brief treatment on enzymatic reaction mechanism and its regulation, Enzyme inhibition and regulation.

2. Digestive system, digestion and absorption of food.

3. Vitamins: Physiological action and sources of Vitamin A, D, K and thiamine, riboflavin, niacin, pantothenic acid, cyanocobalamine, folic acid and ascorbic acid.

4. Metabolism:

(a) Carbohydrate: glycolytic pathway, TCA Cycle.

(b) Biological oxidation-reduction: electron transport chain and oxidative phosphorylation.

(c) Lipid: beta oxidation, biosynthesis of fatty acid and cholesterol.

(d) Protein: transamination, deamination, decarboxylation; urea cycle.

(e) Protein biosynthesis, different types of RNA, simple treatment of protein biosynthesis, genetic code.

5. Hormones: Effects of insulin, thyroxine and glucocorticoids on cellular metabolism.

Books Recommended:

1. D.L. Nelson & M.M. Cox, Lehninger Principles of Biochemistry, W. H. Freeman, New York.

2. J.M. Berg, J.L. Tymoczko and L. Styer, Biochemistry, W. H. Freeman, New York. 3. E. E. Conn and P.K. Stumps, Outlines of Biochemistry, John Willey & Sons. 4. J.L. Howland, Cell physiology, Macmillan, New York. 5. R.K. Murray, D.K. Granner, P.A. Mayes and V.W. Rodwell, Harper’s Illustrated

Biochemistry, McGraw-Hill. 6. US Environmental Protection Agency, Green Chemistry Expert System.

http://www.epa.gov/ oppt/ greenchemistry/ pubs/ gcesdownload.html (accessed February 2009).

55

Course Code: CHEM 4101 Applications of Spectroscopic Methods in Chemical Analysis


1. Ultraviolet (UV) and Visible (Vis) Spectroscopy: Shifts of bands with solvents, The isolated double bond, conjugated double bond, conjugated dienes, Woodward-Fieser rule for calculating �-max, Splitting of electronic energy levels and spectroscopic states, spectra of d1 , d2 , d5 , d8 and d9 complexes, Charge transfer spectra.

2. Infrared (IR) and Raman Spectroscopy: FT-IR, Application of IR spectroscopy,

Interpretation of IR spectra, Characterization of functional groups and frequency shifts associated with structural changes-Structure elucidation, Raman spectroscopy and its application, Combined IR-Raman spectroscopic studies for structural determination.

3. Nuclear Magnetic Resonance Spectroscopy: Nuclear spin, Common nuclei with

spin (1H, 13C, 15N, 19F, 31P), Chemical Shift, Theory of PMR spectroscopy, Shielding and deshielding, Spin-spin splitting, Coupling constant, Complex spin-spin splitting, First order and non-first order spectra, Vicinal, geminal, ortho, para and meta coupling, Proton exchange reactions, Rotation about single bonds, Variable temperature spectra, Geminal and vicinal coupling-nonequivalence of protons relaxations, Simplification of complex spectra, LSR & spin decoupling, New techniques in FT-NMR-NOE-difference spectra, 2D techniques: COSY NOESY, HETCOR, 13C spectroscopy, Operating frequency, 1H decoupling, Off resonance decoupling, Broad band and gated-DEPT, Special pulse techniques.

4. Mass Spectroscopy: Ionization of a molecule on electron impact, The principles of

mass spectrum, Detection of the presence of the isotopes, Reorganization of molecular ion peak, Metastable ions, Fragmentations: McLafferty rearrangement, Nitrogen rule, Mass spectra of different classes of organic and organometallic compounds, CI, EI and FAB mass spectroscopy.

5. Structure elucidation: By combined UV, IR, NMR (1H and 13C) and Mass Spectra. Books Recommended:

1. D.L. Pavia, G.M. Lampman, G.S. Kriz, Introduction to Spectroscopy, Thomson Brooks/Cole.

2. P.S. Kalsi, Spectroscopy of Organic Compounds, New Age. 3. D.H. Williams and I. Fleming, Spectroscopic Methods in Organic Chemistry, Tata

McGraw-Hill, New Delhi. 4. H. Duddeck and W. Dietrich, Structure Elucidation by Modern NMR, Springer

Verlag. 5. W. Kemp, Organic Spectroscopy, Macmillan, London. 6. V.R. Dani, Organic Spectroscopy, Tata McGraw Hill Publishing. Company, New

Delhi. 7. R. Chang, Basic Principles of Spectroscopy, McGraw Hill.

56

8. R.M. Silverstein, G.C. Bassler and T.C. Morrill, Spectrometric Identification of Organic compounds, John Wiley.

9. M. R. Islam and M. A. Huq, Modern NMR Spectroscopy (in Bangla), Ashrafia Bio Ghar, Bangla Bazar, Dhaka.

10. M. R. Islam and M. A. Huq, Modern Mass Spectroscopy (in Bangla), Ashrafia Bio Ghar, Bangla Bazar, Dhaka.

Course Code: CHEM 4102 Solid State Chemistry & Chemical Crystallography

(Full Marks: 20 + 10 + 70 = 100; 3 Credits) PART A (Solid State Chemistry) 1. Classification of Solids: Crystalline solids, Amorphous solids, Distinction between

crystalline and amorphous solids, Molecular crystals (van der waals crystal), Covalent crystals, Ionic crystals, Metallic crystals, Hydrogen bonding in crystals; Born-Haber cycle, lattice energy of an ideal ionic crystal.

2. The Crystal Structures of Ionic Materials: Rock salt NaCl, Niccolite/nickel

arsenide NiAs. Zinc blende/sphalerite ZnS, Wurtzite ZnS, Caesium sloride CsCl, Fluorite CaF2, Rutilr TiO2, Cadmium iodide Cdl2, Cadmium CdCl2.

3. Defects and Non-stochiometry: (a) Lattice defects: inherent thermodynamic defects,

Schottky and Frenkel defects, equilibrium concentration of Schottky and Frenkel defects, (b) Other imperfections: point-defects, line defects, plane defects, edge and screw dislocations, Hall effect, colour centre, (c) Non-stoichiometry: Nonstoichiometry alkali metal halides, transition metal oxides and sulphides, (d) Impurity: foreign impurity atoms or ions, impurity in a semi-conducting elements, (e) Experimental investigation of lattice defects: ionic conductivity and self-diffusion, density.

PART B (Chemical Crystallography) 1. Importance and scope of chemical crystallography, Solid state: crystalline and

amorphous solids. 2. Symmetry Operations and Space Groups: Crystal lattice: Lattice types, Symmetry

elements; Unit cell, Point groups, Space groups, Transformation theory; Group theory, Notation of crystal faces, Crystal systems, Projection of crystals.

3. X-Ray Diffraction Techniques: The powder method, The Debye-Scherrer powder

camera, Guinier focusing camera, The powder diffractometer, Indexing of reflections, Systematic absences, Structure factors, High temperature powder diffraction: effect of crystal size on the powder pattern.

4. Single Crystal X-Ray Diffraction: Bragg’s law, The reciprocal lattice, Growing crystals, Choosing crystals, Shaping crystals, Crystal mounting and alignment,

57

Measurement of crystal properties, Rotating crystal method, Oscillation, Weissenberg technique, Precession camera, Four-circle diffractometer, Structure factor, Electron density mapping, Fourier synthesis, The phase problem, The Patternson synthesis; the overall procedure; Computational task.

Books Recommended: 1. Anthony West, Solid State Chemistry and its Applications, Wiley. 2. A.K. Galwary ,Chemistry of Solids, Chapman and Hall, London. 3. C.N.R. Rao and J. Gopalakrishnan, New Directions in Solid State Chemistry,

Cambridge University Press. 4. P. W. Atkins, Physical Chemistry, W. H. Freeman & Co. 5. A. L. G. Rees, Chemistry of the Defect Solid State, Methuen, London. 6. F.A. Krager, The Chemistry of Imperfect Crystals, North Holland, Amsterdam. 7. W. E. Granes, Chemistry of the Solid State, Bulterworths, London. 8. T.J. Gray, D.P. Detwiler, D.E. Rase, W.G. Lawrence, R.R. West and T.J. Jennings,

The Defect Solid State, Interscience, N.Y. 9. H.V. Keer, Principles of the Solid State, Wiley Eastern Ltd. 10. F.C. Philips, An Introduction to Crystallography, John Wiley & Sons. 11. Buerger, Introduction to Crystal Geometry, McGraw Hill. 12. Wells, Structural Inorganic Chemistry, Clarendon Press, Oxford. 13. G.H. Stout and L.H. Jensen, X-ray Structure Determination : A Practical Guide,

Wiley-Interscience. 14. Wheatley, The Determination of Molecular Structure, Calarendon Press, Oxford. 15. Lipscomb and R.A. Jacobson, X-ray Crystal Structure Analysis, In Techniques of

Chemistry, (ed. A. Welssberger and B.W. Rosster), IIID, Willey Interscience, New York.

16. Ladd and R.A. Palme, Structure Determination by X-ray Crystallography, Plenum, New York.

Course Code: CHEM 4103 Polymer Chemistry

(Full Marks: 20 + 10 + 70 = 100; 3 Credits) 1. Polymer Structure: Definition of Polymer, Difference between polymers and

macromolecules, Classification of polymers, Degree of polymerization, Nomenclature and tacticity, Basic structure of polymers (linear and branched polymers; moderately cross linked polymers), Molecular forces and chemical bonding in polymers.

2. Molecular Weight and Size of Polymers: Number average, molecular weight

average, Z-average and viscosity average molecular weight, Distribution of molecular weight, Determination of molecular weight by end group analysis, Osmotic pressure measurement, Light scattering, Viscosity measurement and ultracentrifugation.

58

3. Polymerization: Types of Polymerization: (a) step-reaction (condensation) polymerization: mechanism and kinetics of stepwise polymerization, statistic molecular weight control, (b) radical chain (addition) polymerization: mechanism-initiation, propagation, termination, kinetics and thermodynamics of radical polymerization, degree of polymerization and chain transfer, ceiling temperature, (c) cationic and ionic polymerization: similarities and contrasts in ionic polymerization, mechanism and kinetics of cationic anionic polymerization, living polymers. Radiation and photo-polymerization.

4. Preparation with Mechanism, Properties and Uses: Phenol-formaldehyde resins,

melamine-formaldehyde resins,, urea-formaldehyde resins, epoxy resins, polyester polyamide, polyethylene, PVC, polystyrene, natural and synthetic rubber.

5. Rheology and Mechanical Properties of Polymers: Flow behavior of polymers:

Newtonian and non- Newtonian flow, Elasticity, Viscoelasticity, (viscoelastic properties of polymers); glass transition temperature (Tg); mechanical properties of crystalline polymers: crystallinity, the crystalline melting point etc.

�

6. Biological Polymerization, Biophysics/ Natural Polymer: Introduction, Nucleic acid, Protein, Enzymes, silk, wool, Collagen, Biopolymer from renewable resources, Polysaccharide, Starch, Chitin/Chitosan, Alginate, Fatty acid.

�

7. Technology: i) Elastomer: Introduction, Processing, Vulcanization ii) Fibers: Introduction, Production, Textile fibers, Natural fibers. iii) Plastic: Overview, Processing, Thermoset/ Thermoplastic, Polymer Blends.

Books Recommended: 1. Padma L. Nayak and S. Lenka, Textbook of Polymer Science, Kalyani. 2. V. R. Gowarker, N. V. Viswanathan and Jayadev Sreadhar: Polymer Science, New

Age. 3. Hans-Georg Elias, Introduction to Polymer Science, Wiley-VCH, Weinheim. 4. R.B. Seymour, An Introduction to Polymer Chemistry, International Student

Edition, McGraw-Hill. 5. M. G. Arora, M. Singh and M.S. Yadav, Polymer chemistry, Anmol Publications

Pvt. Ltd. 6. Fred W. Billmeyer, Textbook of Polymer Science, Wiley-Interscience. 7. G. S. Misra, Introductory Polymer Chemistry, Wiley Eastern Ltd, India. 8. M.S. Bhatnagar, A Textbook of Polymers, vol. 1, S. Chand and Co. Ltd.

59

Course Code: CHEM 4104 Environmental Chemistry


1. Chemistry of the Air Environment: Composition of atmosphere, Types of chemical pollutants in air and their sources, Chemical and photochemical reactions and their consequent effects; Environmental effects of oxides of carbon, nitrogen and sulfur, hydrocarbons and ozone, Metallic particulates in the atmosphere, The automobiles as polluter, Acid rain, Environmental radioactivity.

2. Green House Effect (Global Warming and its mechanism): Green houses gases,

Sources and sinks, Green house potential of different gases, Consequences of green houses effect: global and Bangladesh perspective, Remedial actions to be taken for offsetting the greenhouse effect.

3. Ozone Layer Depletion: Causes and mechanism, CFC’s and their role, Chemical

formulae of CFCs from numbers chemistry of ozone depletion in stratosphere, ODP, Implications of Ozone depletion, Remedial Measures, Montreal treaty and other international treaties for protecting the ozone layer, Air particulate matters, Aerosols: theirs primary sources and effects on human health.

4. Chemistry of the Water Environment: Sources of water pollution, Classes of

polluted water, Standard for drinking water, Measuring DO, BOD, COD, and DOC, Mobilization of arsenic in ground water, Arsenic and human health, Bangladesh scenario, Oceanic dumping, Effects of pollution on oceans, Sewerage and its effects, Sewerage treatment.

5. Pesticides: Definition and types; Structure and properties of different pesticides,

Mode of action of pesticides, Toxicity, Toxicity rate, MLD, LD50, and pT, Behavior of pesticides in soil, Organochlorine compounds, Organophosphates and carbamates, Effects of pesticides on environment, Hazards to human life, Integrated pest management (IPM), Environment friendly insecticide and pesticides.

6. Environmental Pollution in Agriculture: Agro-chemicals, uses and misuses,

Bangladesh perspective, Need for the development and use of comprehensive slow release chemical fertilizers, Micronutrients in soil.

7. Biogeochemical Cycles: Carbon transport in the major world rivers with particular

reference to Bangladesh, Sulphur and nitrogen cycles, Biogeochemical parameters of different soil zones of Bangladesh.

8. Waste Treatment: General understanding of waste in society, Wastes in various

industries, Carriers of wastes: solid, water and other liquids and gas, General principles of waste treatment, Treatment in dye, tanning and other industries relevant to Bangladesh, Municipal and industrial wastes, Waste utilization, Recycling strategy: principles and practice, Economics of recycling.

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Books Recommended:

1. Stanley E. Manahan, Fundamentals of Environmental Chemistry, CRC Press. 2. L.T. Pryde, Environmental Chemistry, Cummins. 3. R.W. Raiswell, P. Brimblecombe, D.L. Dent and P.S. Liss, Environmental Chemistry,

Wiley. 4. J. W. Moore and E. A. Moore, Environmental Chemistry, Academic Press. 5. Werner Stumm and James J. Morgan, Aquatic Chemistry, Wiley-Interscience.

Course Code: CHEM 4105 Theoretical Organic Chemistry


1. Acids and Bases: Effect of solvents on the strength of acids and bases, Hammett’s acidity function, Grunwald-Acidity scale, Effect of structure on the strength of acids and bases, Acid base catalysis: specific and general acid catalysis, specific base catalysis, Brönsted catalysis law, Mechanism of acid and base catalysis, Hard and soft acids and bases.

2. Structure and Reactivity: Quantitative treatment, The Hammett-Equation,

Significance of σx and ρ, Modification of σ, σx+, σx

-, Yukuwa-Tsuno equation, Taft equation, Solvent effect, Grunwald-Winstein equation, Dirmoroth’s Er parameter, Uses of Hammett plots, Spectroscopic correlations, Thermodynamic implication.

3. Free Radical Reaction: Long lived and short lived free radicals: production and

detection of free radicals, configuration of free radicals, type of free radical reactions and general characteristics, Homolysis and free radical displacements: free radical halogenation, iodine exchange reactions, Sandmeyer reaction, additions and rearrangements of free radicals, polymerization, Homolytic elimination and cyclizations.

4. Rearrangement Reactions: Electron deficient skeletal rearrangement, Mechanism

and energy diagram of 1,2-shift, Non-classical carbonium ion, Detection and stereochemistry of rearrangement, Migration to carbon: Wagner-Meerwein, pinacol, and related rearrangements, Migration to nitrogen: Hofmann Lossens, Curtius Schmidt, Beckmann rearrangements, Electron rich rearrangements, Setevens-Favorskii rearrangements, Transannular reactions.

5. Orbital Symmetry Controlled Reactions: Analysis of electrophile, Cycloaddition

and sigmatropic reactions, Anionic oxy-Cope reactions, Cope and Claisen rearrangements.

6. Photochemistry: Theory of photochemistry, Electronic transitions,

Photosensitization by energy transfer, Photoaddition Photoreduction, Substitution

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reactions fragmentation and rearrangement, Photochemical reactions of conjugated aromatic and heterocyclic systems.

Books Recommended:

1. Francis Carey and J. R. Sundberg, Advanced Organic Chemistry, Part A & B, Plennum Press, New York and London.

2. T.H. Lowry and K. S. Richardson, Mechanism and Theory in Organic Chemistry, Harper Collins Publishers, Inc., New York.

3. M.B. Smith, Organic Synthesis, McGraw-Hill, Inc., New York. 4. P. Sykes, A Guide Book to Mechanism in Organic Chemistry, Longman. 5. J. March, Advanced Organic Chemistry, McGraw-Hill. 6. J. Hine, Physical Organic Chemistry, McGraw-Hill. 7. C.K. Ingold, Structure and Mechanism in Organic Chemistry, Bell & Sons, Ltd.,

London 8. D.C. Nonhebel and J.C. Walton, Free Radical Chemistry, Cambridge Univ. Press. 9. P de Mayo, Molecular Rearrangement, Inter Science. 10. J. Kopecký, Organic Photochemistry: A Visual Approach, Wiley-VCH Verlag

GmbH.

Course Code: CHEM 4106 Chemistry Research Methodology


1. Fundamentals of Research: Aim and scope, Brief idea about research, Research process, Research objectives, Research question and hypothesis, Research problem and Non-research problem.

2. Literature Review: Chemical abstract review, Journals related to chemical science.

3. Research Design: Research design and its types, Experimental and non-experimental

design, Validity in experiments.

4. Sample Design: Sample design, Types of sampling procedures.

5. Research Proposal: Proposal development, Components of research proposal.

6. Writing scientific papers and reports: Format of scientific report, Details of writing scientific report.

Books Recommended

1. W.G. Cochran and G.M. Cox, Experimental Design, John Wiley and Sons Inc., London.

2. M. Nurul Islam, (2011), An Introduction to Research Methods (2nd ed.), Mullick and Brothers, New Market, Dhaka.

3. M. Nurul Islam, (2011), An Introduction to Sampling Methods (Rev. ed.), Mullick and Brothers, New Market, Dhaka.

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4. O.N. Bishop, Statistics for Biology, A Practical Guides for the Experimental Biologists, Longman, UK.

Course Code: CHEM 4107 Organo-applied Chemistry Sessional


1. Analysis of Fats and Oils: Determination of acid value, iodine value and saponification value of supplied oil (soybean oil, palm oil, olive oil)/fat.

2. Analysis of sugar: Determination of reducing sugar (glucose) and non-reducing sugar (sucrose) content in supplied sample (molasses, juice, cane sugar, etc.).

3. Soap and Detergents: Analysis of total acid, total alkali, free acid and free alkali value of supplied soap or detergent.

4. Food and Drink: Analysis of milk for sugar and protein. 5. Quantitative Estimation of Functional Groups in the Organic Compounds: (i)

Hydroxyl groups (phenols and alcohols), (ii) Carbonyl groups (aldehydes and ketone), (iii) Carboxylic acid group, (iv) Amino group.


Medicinal Chemistry (Full Marks: 20 + 10 + 70 = 100; 2 Credits)

1. General Introduction to Medicinal Chemistry: Classification of drugs, sources,

prodrugs, lead compounds, necessity of new drugs. 2. Drug Action: The pharmaceutical phase, the pharmacokinetic phase and the

pharmacodynamic phase. Methods and routes of administration, ADME, Routes of elimination, Bioavailability.

3. Drug Design: Stereochemistry and drug design, structure-activity relationships

(SAR), Quantitative structure-activity relationship (QSAR), Hansch analysis, Bioisosteres.

4. Receptors and Messengers: Structure and classification of the receptors, Agonist,

Antagonist and partial-agonist, primary and secondary messengers, Neurotransmitters, Ligand-receptor theories.

5. Drug Metabolism: Introduction, aim, site of metabolism, factors affecting

metabolism, phase I and phase II reactions. 6. Drug Discovery, Development and Production. 7. Chemical and Biological Aspects of the Following Classes of Drugs: (a) Local

Anaesthetics (procaine, tetracacine, lidocine), (b) Sulfadrugs (sulfamethoxazole,

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sulfanilamide, sulfadiazine), (c) Antibiotics (β-lactum, ampicillin, amoxicillin, cloxacillin, floxacillin), (d) Anticancer agents (mechloroethamine, 5-flurouracil, methotrexale, doxorubicin, vincristin), (e) Antidiabetic agents (insulin, tolbutamide, glyburide), (f) Cardiac agents (cardiac glycosides, digitoxin, digoxin), (g) Central nervous system stimulants (amphetamine, caffeine), and (h) Depressants (diazepam, barbiturates, propofol, ketamine).

Books Recommended

1. M.E. Wolff (ed.): Burger’s Medicinal Chemistry, John Wiley & Sons, New York. 2. W.E. Foye (ed.): Principles of Medicinal Chemistry, Varghese Publishing House,

Mumbai. 3. Gareth Thomas: Medicinal Chemistry; An Introduction, John Wiley & Sons. 4. G.L. Patrick: An Introduction to Medicinal Chemistry, Oxford University Press. 5. J.H. Block & J.M. Beale (Ed.): Wilson and Gisvold’s Textbook of Organic Medicinal

and Pharmaceutical Chemistry, Lippincott, Williams and Wilkins. 6. J.B. Taylor & P.D. Kennewell, Introduction of Medicinal Chemistry, Ellis Horwood.

UK

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Course Code: CHEM 4201 Quantum Chemistry and Statistical Thermodynamics


SECTION A: QUANTUM CHEMISTRY

1. Development of Quantum Mechanics: Failure of classical mechanics, Black body radiation, de Broglie concept of dual nature of electron/Wave particle duality, Heisenberg uncertainty principle, Schrödinger wave equation, Eigen value and eigen function, Normalization, Orthogonality, Operators, Postulates of quantum mechanics.

2. Application of Quantum Mechanics: Particle in a one dimensional box, Electron in ring, Particle in a three dimensional box, Simple harmonic oscillator, Wave functions of the harmonic oscillator, Application of Schrödinger equation to the hydrogen atom, Separation of variables, Significance of � (), () and R (r) equation, Quantum numbers and total energy of an orbital, Space wave function and radial distribution function.

3. Approximate Methods: Perturbation method, Variation method and self consistent

field method, Application of approximate methods for calculating energies of helium atom, hydrogen molecule ion and hydrogen molecule.

SECTION B: STATISTICAL THERMODYNAMICS

1. Probability Distribution of Particles: Probability and thermodynamic probability, Probability distribution of particles in energy states, Most probable distribution, Derivation of Maxwell-Boltzmann distribution law.

2. Partition Function: Definition and physical significance of partition function,

Separation of partition function, Translational, Rotational, Vibrational, Electronic, and total partition function, Relationship between partition functions and thermodynamic functions. Molar partition function, Application of partition function to monoatomic and diatomic molecules, Statistical expression for equilibrium constant, Equipartition of energy.

3. Quantum Statistics: Maxwell-Boltzmann statistics, Bose-Einstein statistics, Fermi-

Dirac statistics, Electron gas in metals, Specific heat of solids, Einstein and Debye theory of specific heat.

Books Recommended:

1. S. Glasstone, Theoretical Chemistry, Van Nostrand, New York. 2. M.R. Awode, Quantum Chemistry, S. Chand & Co. Ltd., New Delhi. 3. G. Raj, Advanced Physical Chemistry, GOEL Publishing House, Meerut, India. 4. E.D. Kaufmann, Advanced Concepts in Physical Chemistry, McGraw-Hill. 5. L. Pauling and E. B. Wilson, Introduction to Quantum Mechanics, McGraw-Hill. 6. H. Eyring, J. Walter, and G. E. Kimball, Quantum Chemistry, John Wiley. 7. G.S. Rushbrooke, Introduction to Statistical Mechanics, Oxford University Press.

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Course Code: CHEM 4202 Organometallic Chemistry

(Full Marks: 20 + 10 + 70 = 100; 3 Credits) 1. Introduction: Historical background, Classification of organometallic compounds by

bond type, Difference between main groups and transition metal organometallics, The stability of organic compounds.

2. Main Group Organometallics: Classification, General Methods of Preparations,

Properties of organometallics of Groups 13(IIIA) and 14(IVA). 3. Transition Metal Organometallics: Classification of organic ligands, 18-electron

rule and its basis, application and exceptions. 4. Metal carbonyls, Metal nitrosyls and Metal Phosphines: Synthesis, Structures,

bonding and reactions. 5. Synthesis, Bonding, Structures and Properties (including fluxional behavior) of

the Following Types Transition Metal Organometallics: (a) Compounds with 1-electron ligands: �-alkyl, aryl, and halide complexes. (b) Compounds with 2-electron ligands: alkene compounds. (c) Compounds with 3-electron ligands: η3-allyl complexes. (d) Compounds with 4-electron ligands: tricarbonyliron complexes of dienes and

alkynes. (e) Compounds with 5-electron ligands: cyclopentadienyl complexes. 6. Metal-Metal Bonding and Metal Clusters: (a) Transition Metal Carbonyl Clusters: Structure, Synthesis and Reactions, (b) Comparison Between Triosmium and Triruthenium Clusters, (c) Synthesis, Structure and Substitution Reactions of Trimetallic Dodecacarbonyls of

Osmium, (d) Synthesis, Structure and Reactivity of Labile Triosmium Clusters, (e) Synthesis, Structure and Characteristic Reactions of Some Unsaturated Triosmium

Clusters. 7. (a) Stoichiometric Reactions of Transition Metal Organometallics: Oxidative

addition, Reductive elimination and Insertion reactions, (b) Catalytic Reactions of Transition Metal Organometallics: Water gas shift

reaction, Fischer-Tropsch synthesis, Hydroformylation reaction, Homogeneous hydrogenation of unsaturated compounds, Ziegler-Natta polymerization of ethylene and propylene.

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Books Recommended: 1. G.E. Coates, M.L. Green, P. Powell and K. Wade, Principles of Organometallic

Chemistry, Methuen and Co. Ltd. 2. M. Bochmann, Organometalics 1: Complexes with Transition Metal-Carbon �-bonds,

Oxford Science Publications. 3. M. Bochmann, Organometalics 2: Complexes with Transition Metal-Carbon �-bonds,

Oxford Science Publications. 4. A.W. Parkins and R.C. Poller, An Introduction to Organometallic Chemistry,

Macmillan Publishers Ltd. 5. G.E. Coates, M.L. Green, and K. Wade, Organometallic Compounds, Vol. 1 & 2,

Methuen and Co. Ltd. 6. B.F.G. Johnson (ed.): Transition Metal Clusters, Wiley-lnterscience. 7. K. Kundu, Elementary Organometallic Chemistry, Bangla Academy, Dhaka.

Course Code: CHEM 4203 Green Chemistry


1. Introduction to Green Chemistry: Theory and Practice; Green Chemistry: meeting the global challenge.

2. Atom Economy: A measure of the Efficiency of a reaction; Less Hazardous

Chemical Syntheses; Designing safer chemicals. 3. Safer solvents and auxiliaries; Design for energy efficiency; Use of renewable

feedstocks; Reduce derivatives; Catalysis. 4. Real time analysis for pollution prevention; Inherently safer chemistry for accident

prevention. 5. Greening up the Suzuki Reaction; A green, guided inquiry based electrophilic

aromatic substitution for organic chemistry. 6. Household Fenton’s Reagent: A green Homogeneous Catalysis Demo; A greener

bromination of stilbene: TAML Oxidant Activators: Green Bleaching Agents for Paper Manufacturing.

7. Combinatorial Chemistry: Antibiotic drug Discovery; A Greener Approach for the

Measuring of Colligative Properties. 8. Biosynthesis of ethanol from molasses; R Recent applications of biocatalysis in

developing green chemistry for chemical synthesis at the industrial scale.

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Books Recommended

1. E. Weise, Green Chemistry: Innovations for a Cleaner World (VHS), DVD, American Chemical Society: Washington, DC, 2000.

2. N. Ran, L. Zhao, Z. Chen and J. Tao, Green Chem., 2008, 10, 361-372, DOI: 10.1039/b716045c

3. P. T. Anastas and J. C. Warner, Green Chemistry: Theory and Practice, Oxford University Press: New York, 1998, p.30. By permission of Oxford University Press.

4. J. W. Hill and D. K. Kolb, Chemistry for Changing Times, Print 2007; pp 34-35. 5. J. E. Thompson, Biosynthesis of Ethanol from Molasses, Science Division, Lane

Community College, 2006.

Course Code: CHEM 4204 Organic Reagents and Syntheses


1. Oxidation: Oxidation reactions with Cr, Mn compounds, SeO2, Pb(OAc), and peracid, periodate.

2. Reduction Reactions: Catalytic hydrogenation, Reduction with dissolving metals,

Metal hydrides LiAlH4, NaBH4. 3. Interconversion of Functional Groups: (a) Interconversion of function groups,

Transformation of alcohols, Phenols, Halogeno compounds, Nitro compounds, Acids and acid derivatives, (b) Protective groups: the strategy, protection of alcohols, diols, carboxylic acids, amino group, carbonyl groups, their applications in organic syntheses.

4. Formation of Carbon-Carbon Bonds: The principles, Reactions of organometallic

compounds, Grignard Reagents, Organocopper reagents, The use of stabilized carbanions and related nucleophiles, Formation of carbon-hetero atom bonds, Umpolung yields, Stereo selective enolate reactions, Enamines, Michael addition and Robinson annulation, Heck reaction, Suzuki reaction, Stille coupling, Wittig reaction, Reformatsky reaction.

5. Combinatorial Chemistry: Introduction, Principles of combinatorial chemistry,

Methods and techniques of combinatorial synthesis (Library synthesis), Solid phase organic synthesis, Solution phase combinatorial chemistry, Solid phase synthesis of peptides, Hyper-valent iodines and their applications.

6. Strategy in Synthesis: The disconnection approach to synthesis, Concept of a

synthon, Functional group interconversions, Reagent, Synthetic equivalent and target molecule, Synthesis of monofunctional and difunctional compounds: (a) one-group disconnection, disconnection of simple alcohol compounds derived from alcohols, disconnection of simple olefins, ketones, (b) (i) two group disconnections- 1,3-dioxygenated skeletons, (ii) ‘Illogical’ two group disconnection, the 1,2-

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dioxygenation pattern, (c) pericyclic reactions, (d) heterocyclic compounds, Strategy considering all possible disconnections.

Books Recommended: 1. R.K. Mackie and D.M. Smith, Guidebook to Organic Synthesis, Longman. 2. W. Carruthers, Some Modern Methods of Organic Synthesis, Cambridge University

Press. 3. H.O. House, Modern Synthetic Reactions, Benjamin-Cummings. 4. J. March, Advanced Organic Chemistry, Reactions, Mechanisms and Structure, John

Wiley & Sons. 5. M.B. Smith, Organic Synthesis, McGraw-Hill. 6. S. Warren, Designing Organic Synthesis, John Wiley & Sons. 7. G. Jung, Combinatorial Chemistry: Synthesis, Analysis, Screening, Wiley-VCH, New

York.

Course Code: CHEM 4205 Bioinorganic Chemistry


1. Introduction: General aspects, Metal ions in biological systems, Trace and ultratrace metals, Role of metal ions in biological systems, Metallobiosite structures, Ion pumps.

2. Functional Value of the Chemical Elements in Biological Systems: Major chemical properties of chemicals in aqueous solution, Biochemical functions of the chemical elements, The living process, Chemical flow in biology.

3. Metal Management and Electron Transfer: Iron storage and iron transport, Metallothioneins and phytochelatins, Ceruloplasmin, Vanadium storage and transport, Inner-sphere and outer-sphere electron transfer, Blue copper proteins: plastocyanin, azurin, etc., Iron-sulphur proteins: rubredoxins, ferrodoxins, and other models, synthetic models for Fe-S proteins, Cytochtomes.

4. Dioxygen Management:

(a) Storage and Transport: Metalloporphyrins: chlorophyll, heme proteins, Haemoglobin and Myoglobin-model systems, the structures of the natural sites, cooperativity, synthetic blood, Haemerythrin and haemocyanin, other heme proteins.

(b) Involvement in Enzymes: Superoxide dimutases, Peroxidases and catalases,

Oxidases and oxygenases, Ribonucleotide reductase, Zinc, Superacids, Structural role of zinc in proteins, Vitamin B12, Nitrogenases, Oxotransfer

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molybdoenzymes, Nickel enzymes, Role of Cu, Co, Zn, V, and Mo in biologically important reactions.

5. Metals and Health: The application of therapeutic chelating agents, Platinum and

anticancer activity, cis-platin, carboplatin, Gold and antiarthritic agents, auranofin, etc,

6. Metal Toxicity: Iron overload, Mercuric ion reductase, Lead and porphobilinogen

synthase. Books Recommended

1. D. E. Fenton, Biocoordination Chemistry, Oxford University Press. 2. F.A. Cotton, G. Wilkinson and P.L. Gaus, Basic Inorganic Chemistry, Wiley-India. 3. J.A. Cowan, Inorganic Biochemistry: An Introduction, Wiley-VCH, New York. 4. S. J. Lippard and J. M. Berg, Principles of Bioinorganic Chemistry, University

Science Books, Mill Valley, California, USA. 5. I. Bertini, H.B. Gray, S.J. Lippad, J.S. Valentine, Bioinorganic Chemistry, University

Science Books, Mill Valley, California, USA.

Course Code: CHEM 4206 Supramolecular Chemistry

(Full Marks: 20 + 10 + 70 = 100; 2 Credits) 1. Conceptual Foundation of Supramolecular Chemistry: Natural and Artificial

Molecular Recognition. 2. Synthesis and Design of Organic and Inorganic Supramolecular Frame-work:

Cryptands and catenands. 3. Host-Guest Interactions: Calthrate Inclusions. 4. Bio-Inorganic Chemistry: Template synthesis, Metal ion and marco molecular

recognition. 5. Bio-Organic Molecules, Liquid Crystals. 6. Recognition behavior of enzymes, Synthetic enzymes. Drug design and recognition. 7. Surfactants, Micelles, Vesicles; Pre-organization of Interface Active compounds; Self

organization. 8. Some Inorganic Supramolecular Systems: (a) Silicates, (b) Molybdenum and

Vanadium Phosphates, (c) Clays, (d) Inorganic Host-Guest Chemistry, Nano-structures.

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Books Recommended: 1. F.Vogtle, Supramolecular Chemistry, John Wiley and Sons. 2. J.M. Lehn, Nobel Lectures of Chemistry, 1980-90. 3. J.M. Lehn, Supramolecular Chemistry: Concepts and Perspectives, Wiley-VCH,

Weinheim. 4. A. Müller, A. Dress and F. Vögtle (ed.): From Simplicity to Complexity in Chemistry

and Beyond, Vieweg, Wiesbaden. 5. Muller, Reuter and Dillinger, Supramolecular Chemistry: Small Guest in Small and

Large Hosts, Angew. Chem. Int. Ed. Eng., 1995, 34, 2328. 6. R. W. Hay, Bio-inorganic Chemistry, Ellis Horwood Ltd., Halsted Press, New York.

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