Regenerative materials- predictability in performance

Everything You Need

To Build Better Bone

Color-coded labeling makes it easy to select the right bone and/or membrane solution from our complete line of SYMBIOS® regenerative materials.

membrane

synthetic

SYMBIOS® OsteoShield®

d-PTFE Non-Resorbable Membrane

SYMBIOS® OsteoShield®

Titanium-Reinforced d-PTFE Non-Resorbable Membrane

xenograft

SYMBIOS® OsteoShield®

Collagen Resorbable Membrane

allograft

SYMBIOS® PerioDerm® Acellular Dermis

bone

allograft

DBX® PuttyDemineralized Bone Matrix

SYMBIOS® Mineralized Cancellous PowderSYMBIOS® Mineralized Cortical PowderSYMBIOS® Demineralized Cortical PowderSYMBIOS® Mineralized Cortical & Cancellous GranulesSYMBIOS® Demineralized Cortical & Cancellous Granules

synthetic

SYMBIOS® OsteoGraf® LD-300 Low-Density Hydroxylapatite Bone Graft Material

SYMBIOS® OsteoGraf® D-300 Dense Hydroxylapatite Bone Graft Material

SYMBIOS® OsteoGraf® D-700 Dense Hydroxylapatite Bone Graft Material

SYMBIOS® OsteoGraf® Unfilled Syringes Delivery System

xenograft

SYMBIOS® OsteoGraf® N-300 Dense Bovine Bone Graft Material

SYMBIOS® OsteoGraf® N-700 Dense Bovine Bone Graft Material

PepGen P-15® Particulate

PepGen P-15® FLOW

From a company you can trustAt DENTSPLY Implants, we share your commitment to providing the best care for your implant patients. As one of the world’s leading manufacturer and supplier of dental implant solutions, everything we offer is aimed at enhancing your clinical success, including our comprehensive SYMBIOS® portfolio of regenerative products. Clinically proven over time, these versatile products are designed to meet your needs – while supporting your high standards for success.

Choice and performanceYou know strong and stable graft integration is crucial for predictable tissue regeneration. How you achieve this depends greatly on your patient and your choice of regenerative products. Now you can reduce inconsistency and add the predictability you need with one complete line of regenerative products.

SYMBIOS®

– for all your regenerative needsSYMBIOS® is a full range of quality allograft, xenograft and synthetic bone graft and membrane products designed to promote excellent long-term bone growth and stability. This comprehensive offering consistently delivers predictable clinical efficacy, biocompatibility, ease of use and safety you can rely on.

Our allograft partner:Musculoskeletal Transplant Foundation (MTF)

DENTSPLY Implants is proud to partner with MTF as the manufacturer of our allograft product. Founded in 1987, this non-profit service organization is the world’s largest tissue bank accredited by the American Association of Tissue Banks (AATB).

Unlike other tissue banks, MTF is directed by doctors: a Board of Directors and a Medical Board of Trustees comprised of more than 40 surgeons from world-renowned institutions. They alone set MTF’s standards, which are among the most stringent in the industry. The result is the most clinically-sound, safe tissue, processed from the most carefully selected donors, every single time.

Quality and safety assuranceAccess to more donors than any other tissue bank.

MTF maintains exclusive agreements or right-of-first-refusal with the majority of the nation’s organ procurement organizations – for more quality tissue to choose from.

Industry-leading donor selection criteria.

MTF’s standards exceed those set by the AATB, FDA and most tissue banks when it comes to screening for cancer, illegal drug use, maximum donor age, and a host of other conditions.

More deferred donors than accepted.

More than 97% are deferred for not meeting MTF’s criteria. In addition, MTF never takes donors deferred by other tissue banks or direct referrals from funeral homes. Only donors from the United States are accepted for US distribution.

Sterility control measures for a higher level of safety.

All tissue is aseptically processed in ISO 4 (certified) clean rooms, and processes are validated to prevent cross contamination. Each donor is processed individually and tracked.

DBX® Putty Demineralized Bone Matrix offers the highest bone content, optimal osteoinductivity and exceptional handling characteristics when compared to other DBM products.

Easy to use• Highmolecularweightmeansthematerial

maintainsitsphysicalintegrityandresistsmovementunderirrigation

• Readytouseoutofthebox,nopreparationrequired

• Excellenthandlingcharacteristics• Two-yearshelflife• Convenient,ambienttemperaturestorage

High-quality and biocompatible• Highestdemineralizedbonecontent

available–93%byvolume• DBX®sodiumhyaluronatecarrierisasafe

andnaturalsubstancefoundinhumanjointsandocularfluids

• Non-hemolytic–compatiblewithsurroundingbloodcells

• pHBalanced

Proven bone formation through optimal osteoinductivity• DBX®isosteoconductive,andhasbeen

showntohaveosteoinductivepotentialinanappropriatelydesignedmodel

• DBXPuttyhasbeenshownintheUristintramuscularmodel,confirmedhistologicallytobeosteoinductiveandfacilitatestruebonegrowth1

DBX® Putty Demineralized Bone Matrix

DBX® PuttyDemineralized Bone Matrix

0.5 cc syringe 228005

1.0 cc syringe 228010

2.5 cc syringe 228025

1. Zhang M, Powers RM, Wolfinbarger L. Effects of Demineralization Process on the Osteoinductivity of Demineralized Bone Matrix. J Periodontal. 1997;68: 1085-1092.

• Safe, 100% bone particulate• Easy to handle• Predictable outcomes• Three-year shelf life• Convenient, ambient temperature storage• Variety of choices

SYMBIOS® Allograft Particulate

SYMBIOS® Mineralized Cortical Powder250-850 microns

0.25 cc vial 100175

0.5 cc vial 100176

1.0 cc vial 100177

3.0 cc vial 100178

SYMBIOS® Mineralized Cortical & Cancellous Granules0.1-2.0 mm

0.5 cc vial 100191

1.0 cc vial 100192

SYMBIOS® Demineralized Cortical & Cancellous Granules0.5-3.0 mm

0.5 cc vial 120038

1.0 cc vial 120039

SYMBIOS® Demineralized Cortical Powder250-850 microns

0.25 cc vial 120075

0.5 cc vial 120076

1.0 cc vial 120077

3.0 cc vial 120078

SYMBIOS® Mineralized Cancellous Powder250-850 microns

0.5 cc 400172

1.0 cc 400173 2.5 cc 400174

Easy to handle and hydrate, SYMBIOS® Allograft Particulate integrates with natural bone for predictability in performance.

SYMBIOS® OsteoGraf®/N Dense Bovine Bone Graft Material

2. Internal data available upon request.

• Naturalanorganicbovine-derivedmicroporoushydroxylapatite(noextractableproteinbytest2)

• Cell-mediatedresorption• Hydrophilic-cohesiveconsistencywhen

hydrated• Remodelstovitalboneatthesamerateas

hostbone• Predictableincreaseofbonedimension• Effectivebonereplacementgraftmaterial

aloneorwhenmixedwithautogenousboneand/orDFDBA

SYMBIOS® OsteoGraf®/N-300Dense Bovine Bone Graft Material 250-420 microns

4 each, 1.0 g vials 930000104

4 each, 3.0 g vials 930000304

SYMBIOS® OsteoGraf®/N-700Dense Bovine Bone Graft Material 420-1000 microns

4 each, 1.0 g vials 930000104

4 each, 3.0 g vials 930000304

SYMBIOS® OsteoGraf N is a sintered bovine-derived hydroxylapatite, which is conducive to cell-mediated resorption and provides a scaffold for new bone growth, which holds dimension until host bone takes over.

PepGen P-15® Particulate P-15 Peptide

PepGenP-15®particulate250-420 microns

2 each, 1.0 g vials 99U000102

4 each, 1.0 g vials 99U000104

2 each, 3.0 g vials 99U000302

PepGen P-15® is a synthetic composite of porous hydroxylapatite and a peptide that mimics the cell-binding portion of Type-1 collagen. PepGen P-15 promotes the attachment of reparative cells and directs in the regeneration of bone.

The Science of P-15 Peptide

• Tissue-engineeredbonereplacementgraftmaterial.• Mimicstheinorganicandorganiccomponentsof

autogenousbone.• IncludesthespeciallydesignedP-15peptide,a

syntheticbiomimeticofthe15aminoacidsequenceofType-Icollagen,whichisuniquelyinvolvedinthebindingofcells,particularlyfibroblastsandosteoblasts.1

• Easytoplaceusingconventionalbonegraftingtechniques.

• PepGenP-15particulateisavailableinthepreferredparticlesizerange:PepGenP-15particulate(250-420microns)packagedin1-gramand3-gramvials.

1. Bhatnagar RS, Qian JJ, Gough CA. The role in cell-binding of a a-bend within the triple helical region in collagen b1(I) chain: Structural and biological evidence for conformational tautomerism on fiber surface. J Biomolecular Structure & Dynamics. 1997;14:547-560.

PepGen P-15® FLOW P-15 Peptide

PepGen P-15® FLOW is PepGen P-15® suspended in an inert hydrogel that provides superior handling and ease of delivery in a gel form.

ThePredictableChoice

• Firstandonlybiomimeticofautogenousbone.• Providessuperiordefectfill.• Minimizescrestalboneloss.• Predictable,dependablelong-termresults.• Histologicconfirmationofboneregeneration.• PepGenP-15FLOW:PepGenP-15particulate

suspendedininertbiocompatiblehydrogelpackagedin0.5ccand1.0ccsyringes.

PepGenP-15®FLOW250-420 microns

2 each, 0.5 cc syringes 99U100052

4 each, 0.5 cc syringes 99U100054

2 each, 1.0 cc syringes 99U100102

4 each, 1.0 cc syringes 99U100104

SYMBIOS® OsteoGraf® LD-300 Low-density Hydroxylapatite Bone Graft Material

OsteoGraf® LD is a synthetic bone product that has 56% porosity and high surface area. It is highly radiopaque and provides excellent handling properties.

• Lowdensity,100%puresynthetichydroxylapatite.• Resorbablebonefillingmaterial.• Solution-mediatedresorption.• Hydrophilic-cohesiveconsistencywhenhydrated.• Maintainsalveolarboneforridgepreservation.• Readilyavailablesourceofcalciumforbone

regeneration.• Effectivealternativeforpatientswhoprefera

syntheticmaterial.

References available upon request.

SYMBIOS® OsteoGraf® LD-300Low-density Resorbable Bone Graft Material 250-420 microns

4 each, 0.5 g vials 940000054

4 each, 1.0 g vials 940000104

4 each, 3.0 g vials 940000304

SYMBIOS® OsteoGraf® D Dense Hydroxylapatite Bone Graft Material

OsteoGraf® D is a synthetic dense ceramic HA and can be successfully used in dental applications where maintenance of bulk and contour of the restoration and the ridge is needed.

• Dense,100%puresynthetichydroxylapatite.• Nonporous,non-resorbable,permanentgraft

material.• Providessupportingmatrixforboneand/or connectivetissuedeposition.• Atrophicridgescanbeaugmentedinboth

heightanddimension.• Maintainsaugmenteddimensionforesthetic

orprostheticsupport.• Reducesresorptionrateofunderlyingbone.• Availableintwoparticlesizes.

SYMBIOS® OsteoGraf® D-300Dense Hydroxylapatite Non-Resorbable Bone Graft Material 250-420 microns

4 each, 1.0 g vials 920000104

SYMBIOS® OsteoGraf® D-700Dense Hydroxylapatite Non-Resorbable Bone Graft Material 420-1000 microns

4 each, 1.0 g vials 900000104 4 each, 3.0 g vials 900000304

SYMBIOS® OsteoGraf® SyringesUnfilled Straight Syringes

4 each, Straight 90000S004

References available upon request.

SYMBIOS® PerioDerm® is an acellular dermal allograft designed for predictability in replacing damaged or inadequate tissue in the repair, reinforcement or supplemental support of soft tissue defects. It is minimally processed to remove epidermal and dermal cells while preserving the extra-cellular matrix. The removal of viable cells and antigens during the decellularization process minimizes the risk of rejection and inflammation at the surgical site. The remaining matrix serves as a framework for cellular infiltration and vascularization. SYMBIOS PerioDerm Acellular Dermis has been shown to support the migration of host cells from wound margins and surrounding tissues.

Minimally processedSYMBIOS® PerioDerm® Acellular Dermis undergoes a three-phase process that gently cleans, decellularizes and disinfects without cross-linking or compromising the integrity of the dermal matrix. This proprietary process results in a product that passes United States Pharmacopeia USP<71> Sterility Tests.

Step 1. Sodium Chloride SYMBIOS® PerioDerm® Acellular Dermis is soaked in a sodium chloride solution that promotes plasmolysis, removing the epidermis and disrupting cells while leaving the extracellular matrix intact.

Step 2. Triton SYMBIOS® PerioDerm® Acellular Dermis is washed in Triton, a mild detergent that removes cellular debris to reduce surgical site inflammation and rejection.

Step 3. DisinfectionThe disinfection process provides a 6.0 log 2 (nearly a million-fold) reduction in microbial levels, including bacteria, fungi, spores, mold, yeast, and a 4-6 log 2 reduction of viral load, minimizing disease transmission and cross contamination.

SYMBIOS® PerioDerm® Acellular Dermis

The SYMBIOS® PerioDerm® Advantage:

• Excellenthandlingcharacteristics,similartoautologoushumanskingrafts.

• Rehydratesquickly,reducingsurgerytimeandcost.

• Freeze-driedgraftsrequirenorefrigerationandprovidemorestorageoptions.

• Three-yearshelflifereducesneedforinventorymanagement.

• Over90%thicknessconsistencyforuniformrevascularizationandaestheticresults.

• Nocross-linkingforreadyincorporationandlessriskofsurgerysiteinflammationandrejection.

SYMBIOS® PerioDerm® Acellular DermisThin: .4 mm – .8 mm

1 cm x 1 cm 790101

1 cm x 2 cm 790102

1 cm x 4 cm 790104

2 cm x 2 cm 790202

2 cm x 4 cm 790204

SYMBIOS® PerioDerm® Acellular DermisThick: .8 mm – 1.7 mm

1 cm x 1 cm 791101

1 cm x 2 cm 791102

1 cm x 4 cm 791104

2 cm x 4 cm 791204

When positioned as shown with the notch in the upper left-hand corner, the epidermal side of the tissue is facing up.

This resorbable tissue matrix made from Type-I bovine collagen delivers predictability in performance in dental surgery procedures, in the area of a dental implant, bone defect or ridge reconstruction.

• Longer,predictable26-to38-weekresorptiontime.• ManufacturedfromhighlypurifiedType-Ibovine

Achillestendonforsafety.• Multi-layerconstructionassistshealingofboneand

surroundingtissuewhileinnerlayershelppreventcellularandbacterialdowngrowth.

• Uniquefiberorientationprovidesforunusuallyhightensilestrengthandforstableperformancewithsuturesorresorbabletacks.

• Optimizedflexibilityforexcellentwethandling,whilestillallowingmaintenanceofspace.

• Eithersidemaybeplacedonthesite.

SYMBIOS® OsteoShield® Collagen Resorbable Membrane

In Vivo Rate of Resorption Study*

SYMBIOS OsteoShield

Collagen Resorbable Membrane

100 806040200

0 4 8 12 16 20 24 28 32 36

*Data on FileImplant Time (weeks)

% o

f Im

plan

t rem

aini

ng

SYMBIOS® OsteoShield®

Collagen Resorbable Membrane

2 each, 15x20 mm OSCRM1520

2 each, 20x30 mm OSCRM2030

2 each, 30x40 mm OSCRM3040

This non-resorbable yet easily removable d-PTFE membrane is designed for use with extraction site grafting, large bony defects and where primary closure is not possible or desired.

SYMBIOS® OsteoShield® d-PTFE Non-Resorbable Membrane

SYMBIOS® OsteoShield®

d-PTFE Non-Resorbable Membrane

10 each, 12x24 mm OSNRM1224

4 each, 25x30 mm OSNRM2530

• Primaryclosureisnotrequired.Thismembraneisvirtuallyimpervioustobacteria,resultinginminimalriskofbacterialinvasion.

• Byavoidingreleasingincisionsandprimaryclosure,themembranemaintainssofttissuearchitecture,preserveskeratinizedmucosaandrequiresminimalflapreflectionordissection.

• Theexposedmembranemaybeeasilyremovednon-surgicallywithagentletug.

• Medicalgraded-PTFEisbiocompatibleandnon-reactive.

• Micro-machinedsurfacetexturefacilitatescelladhesion,enhancesmembranestability,reducesflapretractionandincreasespull-outstrength.

This titanium-reinforced membrane is designed for use with large defects, two- or three-walled defects, or where space-making is required. It has all the benefits of SYMBIOS® OsteoShield® d-PTFE Non-resorbable Membrane plus:

• Self-supportingtitanium-reinforcement,whichhelpscreateadditionalspace,especiallyindefectswithdeficientbonyarchitecture.

• Titanium-reinforcementpreventsfoldingorwrinkling.• Grade1titanium,whichisflexible,foreasy

membraneshaping.

SYMBIOS® OsteoShield®

Titanium-reinforced d-PTFE Non-resorbable Membrane

4 each, 12x20 mm OSTRNRM1220

2 each, 25x30 mm OSTRNRM2530

SYMBIOS® OsteoShield® d-PTFE Titanium-reinforced Non-resorbable Membrane

SYMBIOS® from DENTSPLY ImplantsSYMBIOS® regenerative materials provide predictability in performance – from a company you can count on to serve your needs. DENTSPLY Implants makes it easy for you to get the kind of support you need, when you want it.

For more information, contact your local DENTSPLY Implants representative, register for one of our CE programs or visitwww.dentsplyimplants.com.

BoneCollectorA re-usable option for the harvesting of valuable bone chips during preparation of the implant site. It is used in conjunction with disposable titanium filters and suction tubes, that are sold separately.

BoneTrap™

You can quickly and easily collect the patients’ own bone during implant surgery. BoneTrap is disposable and delivered sterile, eliminating the need for cleaning and sterilization

MicrowSawWith its precise, minimally-invasive osteotomy line, the MicroSaw sets new standards in fast and atraumatic harvesting of bone blocks and flaps. The MicroSaw is part of a comprehensive set of instruments designed to support successful augmentation with autogenous bone.

For your autograft needs, DENTSPLY Implants also provides:

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About DENTSPLY ImplantsDENTSPLY Implants offers comprehensive solutions for all phases of implant therapy, including ANKYLOS®, ASTRA TECH Implant System™ and XiVE® implant lines, digital technologies such as ATLANTIS™ patient-specific CAD/CAM solutions, guided surgery, regenerative bone solutions, and professional development programs. DENTSPLY Implants creates value for dental professionals, and allows for predictable and lasting implant treatment outcomes, resulting in enhanced quality of life for patients.

About DENTSPLY InternationalDENTSPLY International Inc. is a leading manufacturer and distributor of dental and other healthcare products. For over 110 years, DENTSPLY’s commitment to innovation and professional collaboration has enhanced its portfolio of branded consumables and small equipment. Headquartered in the United States, the Company has global operations with sales in more than 120 countries.

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www.dentsplyimplants.com • 800-531-3481