symptom management for ptsd - health services … m repetition program* 1. ... “to cross the...
TRANSCRIPT
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Symptom Management for PTSD:
Mantram Repetition Program Randomized Clinical Trial Results
Jill E. Bormann, PhD, RN, FAAN
Associate Nurse Executive/Nursing Research
Clinical Professor
VA San Diego Healthcare System
Center of Excellence for Stress & Mental Health
Hahn School of Nursing & Health Sciences, University of San Diego
San Diego, CA
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Acknowledgements Funding: VA Office of Research & Development
VA HSR&D - Nursing Research Initiative (04-041)
VA CSR&D - Meditation & PTSD (SPLE-003-11S)
Contents do not represent the views of Department of Veterans Affairs
or the United States Government. Authors have no conflicts of interest.
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Objectives
1. Identify the components of the Mantram Repetition Program (MRP).
2. Describe the differences between two randomized controlled trials on MRP for Veterans with PTSD.
3. Describe the PTSD-related outcomes in symptom severity from two randomized controlled trials.
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POLL QUESTION 1
What is your primary role/position in the VA?
1. Administrative (non-clinical)
2. Clinician/Healthcare Provider (any discipline)
3. Principle Investigator/Researcher
4. Policy-Maker/Leadership
5. Not listed above (other)
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Objectives
1. Identify the components of the Mantram Repetition Program (MRP).
2. Describe the differences between two randomized controlled trials on MRP for Veterans with PTSD.
3. Describe the PTSD-related outcomes in symptom severity from two randomized controlled trials.
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Mantram Repetition Program*
1. Mantram Repetition
2. Slowing Down
3. One-Pointed Attention
Meditation-based tools for emotional regulation
Ancient, universal practices, cross-cultural
*Adapted from 8 Point Program (E. Easwaran)
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Psycho-spiritual health education/skills
1. Mantram Repetition -- Sanskrit root word “mantra”
“to cross the mind” or “set free from the mind”
to be repeated silently, day or night, to train attention
portable, concentrative practice; meta-cognition
2. Slowing Down – intention with awareness
awareness of being “speeded up!”
“intentionality” versus “automatic pilot”
setting priorities
3. One-Pointed Attention doing one thing at a time versus multi-tasking
mindful attention on mantram or some other task
MRP Components
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A mantram is not a 1. Slogan 2. Motto 3. Affirmation 4. Created self-talk 5. Song or poem
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“The Mantram is . . . . . . a prayer word or spiritual formula, the living
symbol of the highest ideal the human spirit
can respond to and love.
The repetition of the mantram is not a
mechanical exercise – it is a key to our deepest
resources of strength, patience, and love.”
Easwaran, E. (2008). The mantram handbook. Nilgiri Press: Tomales, CA
“The mantram becomes one’s staff of life,
and carries one through every ordeal.”
Mahatma Gandhi
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Mantram Examples Mantram (pronunciation) Definition
Om Mani Padme Hum (Ohm Mah-nee Pahd-may Hume)
An invocation to the jewel (Self), in the lotus of the heart
Namo Butsaya (Nah-mo Boot-sie-yah) I bow to the Buddha
My God and my All St. Francis of Assisi’s mantram
Maranatha (Mar-ah-nah-tha) Lord of the Heart (Aramaic)
Kyrie Eleison (Kir-ee-ay Ee-lay-ee-sone) Lord have mercy
Jesus, Jesus or Lord Jesus Christ Son of God
Hail Mary, full of grace the Lord is with you Catholic Rosary
Om Prema A call for universal love
Rama Eternal Joy within (Gandhi)
So Hum I am that Self within
Om Shanti In invocation to eternal peace
Shalom Peace, wellness
Sheheena Feminine aspect of God
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How to Use a Mantram
1. Choose a mantram word or phrase
2. Repeat it silently
3. Passively ignore other thoughts
4. Repeat silently as often as possible throughout the day/night 5. Use it when you don’t need it first! 6. You will automatically use it when
you DO need it!
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Easwaran. E. (2005). Strength in the storm. Nilgiri Press: Tomales, CA.
Portable counter
& tracking
log
Standard Course Materials
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Research on MRP for PTSD 1. Bormann, J. E., Weinrich, S., Allard, C. B., Beck, D., Johnson, B. & Holt, L. (2014).
Mantram repetition: An evidenced-based complementary practice for military personnel and veterans in the 21st century. In C. E. Kasper & P. W. Kelley (Eds.), Annual Review of Nursing Research, 32, (pp. 79-108). New York, NY: Springer.
2. Bormann, J. E., Oman, D., Walter, K. H. & Johnson, B. D. (2014). Mindful attention increases and mediates psychological outcomes following mantram repetition practice in veterans with posttraumatic stress disorder. Medical Care, 52(12)Supp5:S13-S18. doi: 10.1097/MLR.0000000000000200
3. Bormann, J., Liu, L., Thorp, S., Lang, A. J. (2012). Spiritual wellbeing mediates PTSD change in Veterans with military-related PTSD. International Journal of Behavioral Medicine. 19(4), 496-502
4. Bormann, J. E., Thorp, S. R., Wetherell, J. L., Golshan, S., & Lang, A. J. (2013). Meditation-based mantram intervention for Veterans with posttraumatic stress disorder: A randomized trial. Psychological Trauma: Theory, Research, Practice, and Policy. 5(3):259-267. doi: 10.1037/a0027522
5. Bormann, J. E., Hurst, S. & Kelly, A. (2013). Responses to mantram repetition program from veterans with posttraumatic stress disorder: A qualitative analysis. Journal of Rehabilitation Research and Development, 50(6), 769-784. http://dx.doi.org/10.1682/JRRD.2012.06.0118.
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POLL QUESTION 2
What I am most interested in learning from this seminar
is --
1. The Mantram Repetition Program
2. Any new treatment for PTSD
3. Complementary therapies in general
4. The strength of evidence for Mantram Repetition & PTSD
5. Research methods to study complementary therapies
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Objectives
1. Identify the components of the Mantram Repetition Program (MRP).
2. Describe the differences between two randomized controlled trials on MRP for Veterans with PTSD.
3. Describe the PTSD-related outcomes in symptom severity from two randomized controlled trials.
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Study Differences Study 1: 6-week (90 minute) MRP Group-led 1-site: San Diego
Control: Treatment as Usual (TAU)
MRP viewed as complement to TAU
Study 2: 8-week (60 minute) MRP Individually-led 2-sites: San Diego, CA & Bedford, MA
Control: Present Centered Therapy (active)
MRP viewed as a stand alone treatment
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Study 1: Efficacy of Mantram Repetition on PTSD Symptoms in Veterans
(2005-2009)
Jill E. Bormann, PhD, RN Steve Thorp, PhD Murray Stein, MD, MPH Ariel Lang, PhD Julie Wetherell, PhD Judy Schnack, FNP
Shah Golshan, PhD Madeline Gershwin, MA, RN Jeffrey Matloff, PhD Dilip Jeste, MD
Wendy Belding, MA
Patricia Bone, BS, RN
Funded by VA HSR&D, Nursing Research Initiative (04-041)
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Hypotheses (Summarized)
Veterans randomized to Mantram Repetition Program
(MRP) + Treatment as Usual (MRP + TAU) will have
greater improvements in symptoms than those in TAU
alone from baseline (week 0) to post-treatment (week 6).
Interviews 3 months follow-up “in what ways have you
used mantram?”
Analysis: Repeated measures ANOVA (2 group by 2 time)
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Study 1: Group Descriptions
Control Group (n=75) 6 weeks usual care
Psycho-pharmacology
Case-management
Provider visits prn
Mantram Group (n=71) 6 weeks usual care
Psycho-pharmacology
Case-management
Provider visits prn
along with
Weekly mantram group sessions (90 min/week) How to: - Choose & use mantram repetition - Slow down thoughts & reactivity - Practice one-pointed attention to manage PTSD symptoms
*Usual care between groups was equivalent
19
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Study 1: Design Mixed-Methods Randomized Controlled Trial
Veterans with PTSD
6-week Mantram
+ Tx as Usual (n=71)
6-week Tx as Usual *
(n=75)
R
Crossover to Mantram
+ Usual Care
Qualitative Interviews 3 months
post-treatment
*Treatment as Usual = meds & case management for 6 weeks
7% non-completers
in both conditions
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Inclusion/Exclusion Outpatient veterans 18 years or older Assessed for PTSD diagnosis using CAPS* Stable on PTSD-related meds for 6 weeks Not actively abusing substances No psychotic or personality disorders Not actively suicidal No current complementary therapy practice
Treatment naïve except for PTSD orientation
* Clinician Administered PTSD Scale > 45
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Study 1: Group Results
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Study 1: Clinician Administered PTSD Scale (CAPS) Total Scores - 6 week groups
F(1,144) = 4.12, p < .05 n2p=.03
83.08
66.16
82.83
72.59
40
50
60
70
80
90
Pre-treatment Post-treatment
Mantram = 71
Control = 7675
-10.24
Me
an
Sco
res
-16.92
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CAPS Hyperarousal Change by Groups over Time (range = 0-40)
F(1,144) = 7.82, p < .01 n2p=.05
27.56
22.37
27.39 25.27
10
15
20
25
30
35
40
Week 0 Week 6 (post-tx)
Mantram
Control
Me
an
Sco
res
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Study 1: PTSD Checklist-C F (1,144) = 4.15, p < .05, np2 = .03
61.35
55.76
62.67
60.28
52
54
56
58
60
62
64
66
Pre-treatment Post-treatment
Mantram = 71
Control = 75
Me
an
Sco
res
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Study 1:
BSI-18 Depression Subscale F (1,144) = 7.90, p < .0001, n2p=.05
Me
an
Sco
res
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F (1,144) = 23.85, p < .0001, n2p= .14
Study 1:
Spiritual Wellbeing (FACIT-Sp)
10
15
20
25
30
35
Pre-treatment Post-treatment
Mantram = 71
Control = 75
Me
an
Sco
res
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Study 1: Quality of Life Enjoyment & Satisfaction
F(1,134)= 9.33, p = .003, n2p=.03
34
35
36
37
38
39
40
Pre-treatment Post-treatment
Me
an
Sco
res
Mantram = 71
Control = 75
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Mindfulness Attention Awareness
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POLL QUESTION 3 Do you “regularly/consistently” practice one of the following?
1. Mindfulness Based Stress Reduction practices
2. Transcendental Meditation (TM)
3. Loving Kindness or Compassion Meditation
4. Mantram Repetition Program tools
5. Other type of meditative practices (i.e., yoga, etc. )
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Study 2: Portable Mantram Meditation
for Veterans with Military-Related PTSD (2012 - 2014)
Funded by the Veterans Affairs (VA) Office of Research & Development, Clinical Services Research & Development (CSR&D) SPLE-003-11S
San Diego Jill E. Bormann, PhD, RN, FAAN
Steven R. Thorp, PhD Ariel J. Lang, PhD Erik Groessl, PhD
Susan R. Tate, PhD Pia Heppner, PhD
Carie Rodgers, PhD Danielle Beck, MPH, CCRC
Katie Warren, NP, RN Alexandra Badone, MA, SW
Michelene Wasil, MFT
Bedford A. Rani Elwy, PhD
Mark Glickman, PhD Dorothy Plumb, MA
Princess Osei-Bonsu, PhD Tu Ngo, PhD
Lawrence Herz, MD Shibei Zhao, MPH
Jennifer Johnston, PhD Emily Mohr, PhD
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Hypotheses (Summarized)
Veterans randomized to Mantram Repetition Program (MRP) will have greater improvements in symptoms* from:
1) baseline (week 0) to post-treatment (week 8) 2) baseline (week 0) to follow-up (week 16) than Veterans randomized to a Present Centered Therapy (PCT) control condition. Analysis: Random effects normal linear regressions target variable as the response variable; adjusting for pre-treatment socio-demographic and clinical control variables. Estimate the treatment-by-time interaction as the effect of interest. *CAPS + subscales, PCL-M, Insomnia Severity Index (ISI), others
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Study 2: Treatment Conditions Delivered Individually
Treatment Condition
Mantram Repetition Program (n=89)
8 weeks (1 hour/week) Individual sessions
PTSD Education
Therapeutic Relationship No trauma discussion
Skills training on how to:
choose & use mantram slowing down one-pointed attention
Control Condition
Present Centered Therapy (PCT) (n=84)
8 weeks (1 hour/week) Individual sessions
PTSD Education Therapeutic Relationship No trauma discussion Current issues only Problem-solving
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Study 2: Randomized Trial
R Present
Centered Therapy
(n=81)
8 week post-treatment
(n=69)**
16 week
follow-up
(n=66)
Mantram Repetition
(n=87)
8 week post-treatment
(n=67)*
16 week
follow-up
(n=61)
Recruitment Enrollment
*23% non-completers in MRP
**15% non-completers in PCT
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Inclusion/Exclusion
Outpatient veterans 18 years or older Assessed for PTSD diagnosis using CAPS* Stable on PTSD-related meds for 6 weeks Not actively abusing substances No psychotic or personality disorders Not actively suicidal No current complementary therapy practices * Clinician Administered PTSD Scale > 45
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Study 2: Individual Results
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77.5
52.39 50.62
76.51
62.07 59
40
50
60
70
80
90
Week 0 Week 8 (post-tx) Week 16
Mantram Tx
Present Tx
p=0.002 p=0.02
Change in CAPS Scores by Groups over Time Range 0-136
Me
an
Sco
res
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Change in CAPS Avoidance Scores by Groups over Time (Range 0-56)
30.3
20 18
29.4 24.7
22.3
0
5
10
15
20
25
30
35
Week 0 Week 8 (post-tx) Week 16 (follow-up)
Mantram
Present Centered
p=0.03
p=0.003
Me
an
Sco
res
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Change in CAPS Hyperarousal Scores by Groups over Time (Range = 0-40)
25.5
17.8
17
24.6
22.2
21.1
0
5
10
15
20
25
30
Week 0 Week 8 (post-tx) Week 16 (follow-up)
Mantram
Present Centered
Me
an
Sco
res
p < 0.001 p=0.001
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18.33
14.22
12.74*
16.35
16.62 15.92
0
5
10
15
20
25
Week 0 Week 8 (post-tx) Week 16
Mantram
Present Centered
22-28 = Severe insomnia 15-21 = Moderately severe 8-14 = Subthreshold insomnia* 0- 7 = No significant insomnia
p<0.001 p<0.001
Change in Insomnia Severity Index Scores by Groups over Time (Range 0-28)
Me
an
Sco
res
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Objectives
1. Identify the components of the Mantram Repetition Program (MRP).
2. Outline differences between the MRP and study control conditions.
3. Describe the PTSD-related outcomes in symptom severity from two randomized controlled trials.
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Comparison of Results
Study 1: Short-term improvements in:
1. PTSD symptoms = Total CAPS, hyperarousal & PCL-C
2. Depression, quality of life, spiritual wellbeing & mindful attention
3. Mindful attention & PTSD mediated by frequency of
mantram practice
Study 2: Longer-term improvements in:
1. PTSD symptoms = Total CAPS, hyperarousal & avoidance
2. Post-treatment improvements in PCL-M, depression (PHQ-9), quality
of life (WHOQOL-BRIEF), spiritual wellbeing (FACIT-Sp)
3. Other results pending
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Next Steps?
Collaborate on future studies to include:
Delivery of MRP by chaplains
Military sexual trauma
Homeless women
Employee burnout/nursing “presence”
Early schizophrenia
Bio-markers/brain imaging/HRV
Enlist other PI’s to study MRP
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Mantram f0r Employees 6-session series w CEU’s
Session 1 – TMS #17457 – How to Choose and Use a Mantram–Self Study (anytime)
Session 2 – TMS #18538 - Using the Mantram, How it Works, Stress Response–Self Study (anytime)
Session 3 – SAVE THE DATE –TMS #(to be announced) – 1:00 EST - LIVE meeting via Adobe Connect—Integrating Mantram Repetition into Work, Life & Veteran Care.
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Portable Mindful Strategies for a Healthy
Workforce: Mantram Repetition Series
What employees are saying after taking
Mantram Repetition:
“I’m able to focus on projects one at a time, better. I’m able to assist Veterans in
a calmer manner.”
“Slowing down will help me focus on the Veteran's goals, rather than focusing on
my goals as a provider.”
“The subject matter helping me normalize some of my internal struggles,
allowing me to explore the issue more deeply, with the goal of facilitating
change.”
“It was the greatest gift given to me for the rest of my life.”
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PORTABLE MINDFUL STRATEGIES
FOR A HEALTHY WORKFORCE:
MANTRAM REPETITION
SERIES OF 6 SESSIONS
HOW TO CHOOSE AND USE A MANTRAM
(EES TRACE CODE: 13.MA.SC.V22.PMSHW)
EES Program Evaluation
Report of Results
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Other Resources Vets Find Mantram Repetition Helps PTSD Symptoms – YouTube (KPBS April 3, 2012) http://www.kpbs.org/news/2012/apr/03/vets-find-mantram-repetition-helps-ptsd-symptoms/
Mantram Technique benefits Veterans with PTSD: May 2013 VA Research Currents
http://www.research.va.gov/currents/may13/may13-04.cfm
Study: ‘Mantram’ Meditation Eases PTSD: March-April 2012 Research Currents
http://www.research.va.gov/currents/mar-apr12/
13048 - Mind-Body-Spiritual Strategies for a Healthy Workforce: The Mantram Repetition Program. VA electronic Health University (VeHU): www.vehu.va.gov
www.jillbormann.com
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Contact Info [email protected]
www.jillbormann.com/
http://vaww.visn22.portal.va.gov/MR/default.aspx
For permission to access contact: [email protected]
“We are shaped by what gains our attention
and occupies our thoughts.”
E. Easwaran