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synthesis of (-)-galiellalactone

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2002 other bioactive products other bioactive products U 1300 50 - 211 Synthesis of (-)-Galiellalactone. — Compound (IV) is prepared as intermediate for the known synthetic pathway of (-)-galiellalactone (V) which can be isolated from the ascomycetes Galiella rufus strain A75-86 and is a selective and potent inhibitor of interleukin-6 (IL-6) signalling in HepG2 cells. — (JOHANSSON, MARTIN; STERNER, OLOV; J. Antibiot. 55 (2002) 7, 663-665; Dep. Org. Bioorg. Chem., Univ. Lund, S-221 00 Lund, Swed.; EN) 1

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Page 1: Synthesis of (-)-Galiellalactone

2002 other bioactive products

other bioactive productsU 1300

50 - 211Synthesis of (-)-Galiellalactone. — Compound (IV) is prepared asintermediate for the known synthetic pathway of (-)-galiellalactone (V) whichcan be isolated from the ascomycetes Galiella rufus strain A75-86 and is aselective and potent inhibitor of interleukin-6 (IL-6) signalling in HepG2 cells.— (JOHANSSON, MARTIN; STERNER, OLOV; J. Antibiot. 55 (2002) 7,663-665; Dep. Org. Bioorg. Chem., Univ. Lund, S-221 00 Lund, Swed.; EN)

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