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Synthetic Bone Graft
Agenda
1. Company Profile2. Business Areas3. Types of Bone Graft4. Products5. Indications6. Advantages
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Especialist in Bone Repair and Regeneration
Established since 2008, Medbone® develops and manufactures high quality medicaldevices in the area of bone regeneration, using an innovative and patentedtechnology.
Our medical devices are sold in national and international markets and are used inthe dental, orthopedic and in veterinary surgery.
Medbone - Biomaterials
Mission
Develop and manufacture
HIGH QUALITY medical devices
Offer INNOVATIVE tools to healthcare
professional
IMPROVE the patients quality
of life
Certification
Medbone® is certified by the ISO 9001 and ISO 13485. All our productsare certified by the European Directive 93/42/EEC.
R&D Pipeline*
Taking into consideration the internationalization and constant growth of thecompany, Medbone® early invested in the development of products.
We seek to provide a constant response to the growing needs of the healthcareprofessionals.
* All the industrial property of Medbone is protected.
Business Areas
Examples:Hip Osteotomy Knee Osteotomy Extremities Bone CurettageEtc.
Examples:Broken limbs
Examples:SpineBrain surgery
Examples:ImplantsSinus Lifting
Examples:MaxillofacialSurgeries
Bone Graft
Bone Graft is intended to be used as a bonevoid filler, being applied to repair bonefractures or bone defects that are complexand fail to heal properly.
The ideal Bone Graft
OSTEOCONDUTIVE
OSTEOINDUCTIVE
BIOMECHANICALLY STABLE
DEGRADE WITHIN AN
APPOPRIATE TIME FRAME
RESORBABLE
OSTEOGENIC
BIOCOMPATIBLE
Bone Graft should be:
Bone grafting requires the interation between:
OSTEOINDUCTION OSTEOCONDUCTION
Biocompatible materialthat provides a physicalstructure into and alongwhich bone may grow.
Process that involvesthe stimulation ofosteoprogenitor cellsto differentiate intoosteoblasts that thenbegin new boneformation.
OSTEOGENESIS
Physiological processby which new bone isformed.
Bone Grafting
Allograft: collected from eitherliving donors or nonlivingdonors and must be processedwithin a bone tissue bank.
Autograft: Bone obtainedfrom the same individualreceiving the graft.
Xenograft: Bone from aspecies other than human,such as bovine/porcine bone.
Synthetic Bone Graft: composedof biocompatible calciumphosphate materials that aresimilar to that of bone andcapable of bonding chemically tobone.
Types of Bone Grafts
ADVANTAGES DISADVANTAGES
The Gold Standard in bone substitution
Osteoinductive
Osteoconductive
Osteogenic
No potential for disease transmission orimmunogenic response
Limited availability and surgery time
Second site surgery to obtain the graft
Morbidity in the donor site
Post-operative pain and complications
Need to recover the extraction site
Autograft
ADVANTAGES DISADVANTAGES
Available in various geometric and shapeable forms
Osteoconductive
Cortical allografts may provide structural supportand may be immediately load bearing
Potential for disease transmission and immune rejection
Variable clinical results and inconsistent graft incorporation
Freeze-dried allografts have low compressive strength
Price (€€€€)
Higher availability
Weakly Osteoinductive (if growth factors remainafter processing)
Risk of cross-contamination with bovinespongiform encephalopathy or porcineendogenous retroviruses (xenograft)
Reduced healing time
Allograft / Xenograft
ADVANTAGES DISADVANTAGES
Demineralized bone matrix (DBM)
Inherent osteoconductive
Moldable and adaptable material
Different properties due to the large variability of donors used to harvest the graft
Weak Mechanical resistance
Potential for infectious disease transmission
Price (€€€€)
Higher osteoinductive potential than the allografts
Reduced healing time
DBM bone tissue (from animal or bone bank origin) that has had theinorganic mineral removed, leaving behind the organic "collagen" matrix.
ADVANTAGES DISADVANTAGES
Synthetics
Osteoconductive matrix with a long clinical history
Absence of toxicity, disease transmission and immunogenicity
Less associated pain, blood loss and post-operative complications
Lack of osteoinductive or osteogenic potential
Brittle (in certain cases)
Typically used in non weight bearing applications
Bioactivity, , biodegradability, long shelf-life
Unlimited availability in different shapes, porosities and compositions
Products
COMPOSITION POROSITY
RESORPTION PERIOD
- 100% Synthetic- 25 % TCP + 75% HAp
- 80%- Pore Size : 300 – 500 microns
- 6 to 24 months
COMPOSITION POROSITY
RESORPTION PERIOD
- 100% Synthetic- TCP
- 80%- Pore Size : 300 – 500 microns
- 1 to 6 months
Several Geometries
Granules
Geometric Shapes
Vertical augmentation
Implantology
Maxillary sinus lift
Horizontal augmentation
Alveolar regeneration
Maxillofacial Osteotomy
Maxillofacial & plastic surgery
Peri-implant regeneration
Indications
Main Advantages No risk of infection
High availability
Avoids the painful Autograft removal
Radiopaque, allow the monitorization by a simple X-Ray
Works as atemporaryimplant once isfully reabsorbeand substituteby new bone
There are no bone density differences
between the new formed bone and the
remanant bone
Surgery time reduction
No immunological
risk
Why choose adbone®?
Exceptional Biocompatibility
Extremely Osteoconductive
Excellent Resorption Rate
High Mechanical Resistance
Several Geometries
Custom Made Implants