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Systems Biology Systems Biology Modeling of the Modeling of the Brain in Virtual Cell Brain in Virtual Cell Sherry-Ann Brown, MD, PhD @drbrowncares, [email protected]

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Page 1: Systems Biology Modeling of the Brain in Health & Disease

Systems Biology Modeling of Systems Biology Modeling of the Brain in Virtual Cellthe Brain in Virtual CellSherry-Ann Brown, MD, PhD@drbrowncares, [email protected]

Page 2: Systems Biology Modeling of the Brain in Health & Disease

Modeling in Virtual CellModeling in Virtual Cell

@[email protected]

Brown & Loew, Frontiers in Neuroscience 2015-1

Page 3: Systems Biology Modeling of the Brain in Health & Disease

Modeling in Virtual CellModeling in Virtual Cell

@[email protected]

Brown & Loew, Frontiers in Neuroscience 2015-1

Page 4: Systems Biology Modeling of the Brain in Health & Disease

Modeling in Virtual CellModeling in Virtual Cell

@[email protected]

Brown & Loew, Frontiers in Neuroscience 2015-1

Page 5: Systems Biology Modeling of the Brain in Health & Disease

Hernjak et al, Biophysical Journal 2005

Parallel fiber stimulus

Climbing fiber stimulus

@[email protected]

Calcium Pathways In The Cell

Page 6: Systems Biology Modeling of the Brain in Health & Disease

Modeling in Virtual Cell

@[email protected]

Max

8120

1400

Min

Brown et al, Biophysical Journal 2008

Page 7: Systems Biology Modeling of the Brain in Health & Disease

Modeling in Virtual CellModeling in Virtual Cell Max

8120

1400

Min

@[email protected]

Brown et al, Biophysical Journal 2008

Page 8: Systems Biology Modeling of the Brain in Health & Disease

@[email protected]

Brown et al, Frontiers in Neuroscience 2015-2

Page 9: Systems Biology Modeling of the Brain in Health & Disease

@[email protected]

Brown et al, Frontiers in Neuroscience 2015-2

Page 10: Systems Biology Modeling of the Brain in Health & Disease

@[email protected]

Brown et al, Frontiers in Neuroscience 2015-2

Page 11: Systems Biology Modeling of the Brain in Health & Disease

Modeling in Virtual CellModeling in Virtual Cell

@[email protected]

Brown & Loew, Frontiers in Neuroscience 2015-1

Page 12: Systems Biology Modeling of the Brain in Health & Disease

Modeling in Virtual CellModeling in Virtual Cell

@[email protected]

Brown et al, Frontiers in Neuroscience 2015-2

Page 13: Systems Biology Modeling of the Brain in Health & Disease

Modeling in Virtual CellModeling in Virtual Cell

@[email protected] et al, Frontiers in Neuroscience 2015-2

Page 14: Systems Biology Modeling of the Brain in Health & Disease

Modeling in Virtual CellModeling in Virtual Cell

@[email protected] & Loew, Frontiers in Neuroscience 2015-1

Page 15: Systems Biology Modeling of the Brain in Health & Disease

@[email protected] & Loew, Frontiers in Neuroscience 2015-1

Page 16: Systems Biology Modeling of the Brain in Health & Disease

@[email protected] & Loew, Frontiers in Neuroscience 2015-1

Page 17: Systems Biology Modeling of the Brain in Health & Disease

CitationsTextbooks (11) + Journal articles (34)

@[email protected]

Page 18: Systems Biology Modeling of the Brain in Health & Disease

@[email protected]

Page 19: Systems Biology Modeling of the Brain in Health & Disease

Systems Biology Modeling of Systems Biology Modeling of the Brain in Virtual Cellthe Brain in Virtual CellSherry-Ann Brown, MD, PhD@drbrowncares, [email protected]


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