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Tackling Maternal Anaemia Saves Maternal and Infant Lives 34 TH SCIENTIF IC CONFERENCE OF NUTRITION SOCIETY OF MALAYSIA
Dr Faridah bt Abu Bakar
Public Health Physician & Director
Family Health Development Division
Outline • Current situation of anaemia and maternal anaemia
• Current indicators and target
• Impact of maternal anaemia
• Strategies to tackle maternal anaemia
• Challenges
• Way forward
WHAT IS Anaemia ?
Anaemia is a condition in which the number of red blood cells (and consequently their oxygen-carrying capacity) is insufficient to meet the body’s physiologic needs.
MATERNAL ANAEMIA
Anemia in pregnancy is defined as a hemoglobin concentration of less than 11 g/dL in venous blood.
The GLOBAL Burden of Anaemia
Anaemia is the world’s second leading cause of disability and thus one of the most serious global public health problems (WHO)
Global health problem that affects about 500 million women in 2011 ◦ 496 million non-pregnant women
◦ 32 million pregnant women Global, regional and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant women & non-
pregnant women for 1995-2011: a systematic analysis of population representative data, The Lancet 2013
The most recent estimates for 2016 indicate that anaemia affects 33% of women of reproductive age globally (about 613 million women between 15 and 49 years of age)
Why does ANAEMIA matter?
Impair physical capacity and
work performance
Reduce individual’s wellbeing
Fatigue and
lethargy
Impaired health and
quality of life
Impaired economic
productivity
Impaired development
and learning for children
Prevalence of Anaemia AMONG FEMALE in Malaysia
Women of reproductive age (15-49 years old)
(NHMS 2015)
Pregnant women – at any point during pregnancy
(NHMS 2016) 29% 34.7%
Milman N (2015) – Iron Deficiency And Anaemia In Pregnant Women in Malaysia – Still a Significant and Challenging Health Problem: J. Preg Child Health 2:
168. doi:10.4172/2376-127X.1000168
30.0%
Milman N (2015) – Iron Deficiency And Anaemia In Pregnant Women in Malaysia – Still a Significant and
Challenging Health Problem: J. Preg Child Health 2: 168. doi:10.4172/2376-127X.1000168
38%-42 %
Chethan et.al. 2017 - A Review On Anemia In Pregnancy Condition
Anaemic girls/women enters their reproductive age in an iron depleted state.
Why does ANAEMIA matter? – Girls and women at higher risk
Iron requirements in women throughout life-cycle
9 mg/ day 6 mg/ day 9 mg/ day 33 mg/ day *100 mg/day (non-anemic) 29 mg/day
11 mg/ day
11 mg/ day
Recommended Nutrients Intake For MALAYSIA, 2017 Note: Based On 10% Bioavailability
Nutritional iron deficiency anemia (IDA) is the
commonest cause of anaemia in pregnancy
WHAT CAUSES ANAEMIA IN PREGNANCY?
Nutritional deficiencies
Acute or chronic blood loss -GI bleeding
-heavy menses
Infections -Malaria
-HIV
Chronic diseases -renal failure
-neoplasia
Haemoglobinopathies -Sickle cell
-Thalassaemia
Parasites Physiological
adaptation
• An overall prevalence rate of anaemia in
pregnant mothers 57.4% - a study in Jerteh, Terengganu
• Poor compliance to haematinic intake by mothers was significantly associated with anaemia by the OR of 4.571
Nik Rosmawati et al, 2012 - The Rate and Risk Factors
for Anaemia among Pregnant Mothers in Jerteh Terengganu, Malaysia NH Nik Rosmawati1
Impact of Maternal Anaemia
Mother
Infant
• Increased risk of maternal death • Increased risk of PPH, decreased ability to
tolerate blood loss • Increased risk of sepsis • Heart failure during postpartum • decreased quality of life- increased fatigue,
breathlessness, palpitations and infections • greater stress and depression • less responsive, more controlling and more
“negative” towards their infants negative implications for infant development
• Increased perinatal morbidity and mortality
• SGA, LBW, Preterm birth • Increased risk of developing diabetes and cardiac
disease later in life • Lower iron status in infants • Impaired cognitive developments
Quality Assurance Indicator ◦ National Indicator Approach (NIA) – adopted as QAP in 2013 ◦ State/District Specific Approach ◦ Prevention and control programme for anaemia
◦ Percentage of anaemia among pregnant women at 36 weeks
Family planning programme ◦ for birth spacing using modern contraceptive, exclusive breastfeeding
Health Promotion to mothers/patient ◦ Healthy diet advice ◦ Cooking demonstration ◦ Self-hygiene
Strategies to tackle maternal anaemia
National Indicator Approach for Maternal Anemia
• Quality Assurance Programme - National Indicator Approach (NIA)
• Indicator : Percentage of anemic mothers (Hb<11gm%) at 36 weeks of gestation
NIA: Percentage of women with anaemia at 36 weeks gestation
32.6
28.9 26.7
24 21.5 20.8
16.2 14
11.8 9.1 8.2
7 6.4 6.4
0
5
10
15
20
25
30
35
2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018
%
Year Health Informatics Centre MOH 2005 - 2018
Percentage of women with anaemia
(Hb<11gm%) at 36 weeks of gestation : Malaysia
2017 & 2018
P'lis Kdah P.Pnang Perak KL P'jaya S'gor N9 Mlaka Jhor Phang Tganu Klntan Lbuan Sbah Srwk M'siaSem.Mal
aysiaMalaysia
Timur
2017 19.2 4.5 5.0 6.1 5.0 7.8 4.8 9.2 12.0 4.7 4.7 3.6 6.2 6.5 10.4 10.0 6.4 5.5 10.2
2018 16.4 4.4 4.5 9.2 3.8 6.8 5.3 12.3 13.8 3.7 4.2 3.2 5.3 9.3 10.9 6.9 6.4 5.8 9.3
19
.2
4.5
5.0
6.1
5.0
7.8
4.8
9.2
12
.0
4.7
4.7
3.6
6.2
6.5
10
.4
10
.0
6.4
5.5
10
.2
16
.4
4.4
4.5
9.2
3.8
6.8
5.3
12
.3 1
3.8
3.7
4.2
3.2
5.3
9.3
10
.9
6.9
6.4
5.8
9.3
0.0
5.0
10.0
15.0
20.0
25.0
2017 2018
Strategies to tackle maternal anaemia
Pre-pregnancy care ◦ Intervention of anaemia among women of reproductive age (adolescents and
menstruating women) before embarking on pregnancy
Supplementations for pregnant women and postpartum mothers ◦ Intermittent iron and folate supplementations among pregnant women even
with normal haemoglobin level
Comprehensive management of anemia in pregnancy and postpartum ◦ Multidisciplinary involvement ◦ Close monitoring of haemoglobin level throughout pregnancy and postnatal, and
among family planning users
National Control and Prevention Programme of Thalassemia ◦ To combat non-nutritional anaemia
Percentage of women with anaemia during 1st Antenatal Visit 2009-2015
22.1
29.3
65.1 66.9
31.1
16.6 14.6
0
10
20
30
40
50
60
70
80
2009 2010 2011 2012 2013 2014 2015
%
YEAR
National Obstetrics Registry (Malaysia) 2009 – 2015
Percentage of women with anaemia during admission for delivery 2009-2015
7.3 6.08
24.3 25.2
13
5.6 5.3
0
5
10
15
20
25
30
2009 2010 2011 2012 2013 2014 2015
%
Year
National Obstetrics Registry (Malaysia) 2009 – 2015
Percentage of Anaemia at Booking1, 36 Weeks2 POG & at Delivery1
22.1
29.3
65.1 66.9
31.1
16.6 14.6
21.5 20.8 16.2 14 11.8
9.1 8.2 7.3 6.08
24.3 25.2
13
5.6 5.3
0
10
20
30
40
50
60
70
80
2009 2010 2011 2012 2013 2014 2015
%
Booking
36 weeks
Delivery
1National Obstetrics Registry 2009 – 2015 2Health Informatics Centre MOH 2009-2015
Early Antenatal Booking (less than 12 weeks POG) 2011-2018
66.2
71.2
75.6
79.1 78.4
82.51 83.6
75.6
2011 2012 2013 2014 2015 2016 2017 2018p
Source of data : Health Informatics Centre, MOH
target >70% Early ANC (NHMS2016) 69.1% : 1st Trimester 28.5% : 2nd Trimester
Milman N (2015) – Iron Deficiency And Anaemia In Pregnant Women in Malaysia – review paper – concluded that …’efforts should focus on better implementation of early oral iron and vitamin prophylaxis, early diagnosis of anaemia and on increasing the low compliance women to the prophylaxis program”
No. of clinic equipped with: - Haematology analyser :
660 (61%) - Heamoglobin Analyser
(100%) Quality Assurance for Haematology Analyser: - Internal Quality Control
(IQC) - External Quality Assurance
(EQA)
2016 2017 2018
Male students 2.8 2.7 3.2
Female Students 15.8 17.8 19.3
2.8 2.7 3.2
15.8
17.8 19.3
0
5
10
15
20
25
Pe
rce
nta
ge o
f A
ne
mia
det
ect
ed
Percentage of Anaemia Detected among Form 4 (16yr old) Thalassaemia Screening 2016 - 2018
PerlisKeda
h
PulauPinan
gPerak
Selangor
WPKL
WPPutrajaya
NSembilan
Melaka
JohorPaha
ng
Terengga
nu
Kelantan
Sabah
Sarawak
WPLabu
an
Malaysia
Male Students 4.3 2.5 3.0 3.7 3.2 3.4 2.8 4.8 3.1 2.9 2.2 2.8 2.9 3.1 1.8 1.1 2.9
Female Students 23.5 18.7 19.1 18.6 20.2 17.5 19.8 22.8 19.2 19.4 17.2 14.5 16.0 22.2 13.1 26.0 18.6
0.0
5.0
10.0
15.0
20.0
25.0
30.0
Pe
rce
nta
ge
Percentage Anaemia detected by Gender by State 2017
Prevalence of Anaemia AMONG FEMALE in Malaysia (various years and sources)
Pregnant women at 36
weeks in government
clinics (PIK 2015)
Women of reproductive
age (NHMS 2015)
Pregnant women
(NHMS 2016)
8.2%
29%
34.7%
Female Adolescent (16 year old school girls) (Thalassemia Screening
Program 2017)
17.8%
Anaemia at booking
(NOR) 2015
Anaemia at
delivery (NOR 2015)
14.6% 5.3%
Selected citations on impact of maternal anaemia
Linear association between maternal anaemia and death
◦ With each 1g/dL increase in maternal haemoglobin associated with a 29% reduction in maternal mortality.
Maternal and child undernutrition and overweight in low-income and middle-income countries, The Lancet 2013
Severe anaemia (Hb <7 g/dL) during pregnancy and postpartum doubled the risk of maternal death
Risk of maternal mortality in women with severe anaemia during pregnancy and postpartum : a multilevel analysis (WHO Multi-country
Survey), The Lancet 2018
Correlation of the prevalence of anemia in women and
maternal mortality ratios
THE JOURNAL OF NUTRITION, VOLUME 131, ISSUE 2, FEBRUARY 2001, PAGES 604S–615S, HTTPS://DOI.ORG/10.1093/JN/131.2.604S
0.00
1.00
2.00
3.00
4.00
5.00
6.00
7.00
8.00
9.00
10.00
Post PartumHeaemorrhage
HypertensiveDisorder inPregnancy
PulmonaryEmbolism
Amniotic FluidEmbolism
Ectopic pregnancy
Associated MedicalConditions
ROLLING 3-YEAR AVERAGE CAUSE SPECIFIC MMR Per 100,000 LB FOR COMMON CAUSES OF DEATH : MALAYSIA, 2000 – 2016
Source of data : BPKK
“The results showed that the relationship between anemia in the first trimester and SGA was significant .
However, the results showed that the overall relationship between anemia during pregnancy and SGA was not significant.”
Badfar et.al, 2019 - Maternal anemia during pregnancy and small for gestational age: a systematic review and meta-analysis
Selected citations on impact of maternal anaemia to newborn
Inadequate iron supply may have a negative impact on the growing fetal brain and permanently impair the psychomotor development of the newborn child
-GranthamMc-Gregor et al 2001 – A review of studies on the effect of iron deficiency on cognitive development in children
• No difference noted for hemoglobin level at booking in between cases and control group • Predictors of LBW infants: Younger maternal age, history of LBW infants, prematurity and hypertension
Long term effect on the baby
Global indicators
WHO GLOBAL NUTRITION TARGET
50% reduction in anaemia in women of reproductive age by 2025 from baseline of 2010
SDG TARGET 2.2 :
By 2030, to end all forms of malnutrition, including achieving, by 2025, the internationally agreed targets on stunting and wasting in children under 5 years of age, and address the nutritional needs of adolescent girls, pregnant and lactating women and older persons.
Indicator : Percentage of women in reproductive age (15-49) with anaemia
WHO Recommended Actions - Global Targets 2025 – To improve maternal, infant and young child nutrition
Integrated Planning • Address nutritional and non-nutritional causes of anaemia • Include interventions with an effect on anaemia in national health,
education, agriculture and development plans
Multi-sectoral Approach • Use a multi-sectoral approach to anaemia prevention and control • Ensure that development policies and programmes beyond the
health sector
Strengthen Health Systems • Provide hospital and health facilities-based capacity for anaemia prevention and treatment
• Support antenatal iron and folic acid supplementaton as part of routine antenatal care
Community Support • Raise awareness of the value of iron supplementation in women of reproductive age
• Support community mobilisation and social marketing strategies
Challenges in tackling maternal anaemia..
• Require comprehensive & holistic interventions as anaemia is multifactorial • Early intervention & promotion of healthy eating before pregnant/ in homes/
schools/community
• Hard-to-reach individuals - The greatest burden of anaemia falls on the most "hard-to-reach" individuals, any programme that aims to reduce anaemia will need to be accessible by these groups
• Patient factors • Socioeconomic and contextual/ecological determinants factors, with many acting
simultaneously
• Compliance to iron supplementation is still the major issue
• Non-nutritional anaemia – a portion of anaemia cases will not be caused by iron
Way forward
• Intervention before conception – strengthen pre-pregnancy care services
• Life-course approach - break the intergenerational cycle of nutritional deficiency
• Holistic Interventions • Tackle social determinants • Inter-sectoral collaboration
Critical window of opportunity from conception to 2 years of age (the first 1000 days of life)
Before
1000
days
PPC
OPTIMISE
Thank you